{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:02:48Z","timestamp":1773270168625,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2007,9,11]],"date-time":"2007-09-11T00:00:00Z","timestamp":1189468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1007\/s10571-007-9207-4","type":"journal-article","created":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T11:05:50Z","timestamp":1189422350000},"page":"877-881","source":"Crossref","is-referenced-by-count":8,"title":["No Association Between the LRRK2 G2019S Mutation and Alzheimer\u2019s disease in Italy"],"prefix":"10.1007","volume":"27","author":[{"given":"Andrea","family":"Tedde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Bagnoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Cellini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetta","family":"Nacmias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Piacentini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Sorbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,9,11]]},"reference":[{"key":"9207_CR1","unstructured":"American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. Washington, DC"},{"key":"9207_CR2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1399-0004.2007.00771.x","volume":"71","author":"D Civitelli","year":"2007","unstructured":"Civitelli D, Tarantino P, Nicoletti G, Ciro Candiano IC, Annesi F, De Marco EV, Carrideo S, Rocca FE, Condino F, Spadafora P, Pugliese P, D\u2019Asero S, Morelli M, Paglionico S, Annesi G, Quattrone A (2007) LRRK2 G6055A mutation in Italian patients with familial or sporadic Parkinson\u2019s disease. Clin Genet 71:367\u2013370","journal-title":"Clin Genet"},{"key":"9207_CR3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.parkreldis.2006.06.010","volume":"13","author":"G Cossu","year":"2007","unstructured":"Cossu G, van Doeselaar M, Deriu M, Melis M, Molari A, Di Fonzo A, Oostra BA, Bonifati V, (2007) LRRK2 mutations and Parkinson\u2019s disease in Sardinia\u2014a mediterranean genetic isolate. Parkinsonism Relat Disord 13:17\u201321","journal-title":"Parkinsonism Relat Disord"},{"key":"9207_CR4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/hmg\/7.1.43","volume":"7","author":"M Cruts","year":"1998","unstructured":"Cruts M, van Duijn CM, Backhovens H, Van den Broeck M, Wehnert A, Serneels S, Sherrington R, Hutton M, Hardy J, St George-Hyslop PH, Hofman A, Van Broeckhoven C (1998) Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease. Hum Mol Genet 7:43\u201351","journal-title":"Hum Mol Genet"},{"key":"9207_CR5","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/sj.ejhg.5201539","volume":"14","author":"A Fonzo Di","year":"2006","unstructured":"Di Fonzo A, Tassorelli C, De Mari M, Chien HF, Ferriera J, Rohe CF, Riboldazzi G, Antonimi A, Albani G, Mauro A, Marconi R, Abruzzese G, Lopiano L, Fincati E, Guidi M, Marini P, Stocchi F, Onofrj M, Toni V, Tinazzi M, Fabbrini G, Lamberti P, Vanacore N, Meco G, Leitner P, Uitti RJ, Wszolek ZK, Gasser T, Simons EJ, Breedveld GJ, Goldwurm S, Pezzoli G, Sampaio C, Barbosa E, Martignoni E, Oostra BA, Bonifati V, Italian Parkinson\u2019s Genetics Network (2006) Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson\u2019s disease. Eur J Hum Genet 14:322\u2013331","journal-title":"Eur J Hum Genet"},{"key":"9207_CR6","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","volume":"349","author":"A Goate","year":"1991","unstructured":"Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, Mant R, Newton P, Rooke K, Roques P, Talbot C, Pericak-Vance MA, Roses AD, Williamson R, Rossor M, Owen M, Hardy J (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer\u2019s disease. Nature 349:704\u2013706","journal-title":"Nature"},{"key":"9207_CR7","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1136\/jmg.2005.035568","volume":"42","author":"S Goldwurm","year":"2005","unstructured":"Goldwurm S, Di Fonzo A, Simons EJ, Rohe CF, Zini M, Canesi M, Tesei S, Zecchinelli A, Antonimi A, Mariani C, Meucci N, Sacilotto G, Sironi F, Salani G, Ferriera J, Chien HF, Fabrizio E, Vanacore N, Dalla Libera A, Stocchi F, Diroma C, Lamberti P, Sampaio C, Meco G, Barbosa E, Bertoli-Avella AM, Breedveld GJ, Oostra BA, Pezzoli G, Bonifati V (2005) The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson\u2019s disease and originates from a common ancestor. J Med Genet 42:e65","journal-title":"J Med Genet"},{"key":"9207_CR8","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.parkreldis.2006.04.001","volume":"12","author":"S Goldwurm","year":"2006","unstructured":"Goldwurm S, Zini M, Di Fonzo A, De Gaspari D, Siri C, Simons EJ, van Doeselaar M, Tesei S, Antonimi A, Canesi M, Zecchinelli A, Mariani C, Meucci N, Sacilotto G, Cilia R, Isaias IU, Sonetti A, Sironi F, Ricca S, Oostra BA, Bonifati V, Pezzoli G (2006) LRRK2 G2019S mutation and Parkinson\u2019s disease: a clinical, neuropsychological and neuropsychiatric study in a large Italian sample. Parkinsonism Relat Disord 12:410\u2013419","journal-title":"Parkinsonism Relat Disord"},{"key":"9207_CR9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neulet.2005.07.044","volume":"389","author":"D Hernandez","year":"2005","unstructured":"Hernandez D, Paisan-Ruiz C, Crawley A, Malkani R, Werner J, Gwinn-Hardy K, Dickson D, Wavrant Devrieze F, Hardy J, Singleton A (2005) The dardarin G 2019 S mutation is a common cause of Parkinson\u2019s disease but not other neurodegenerative diseases. Neurosci Lett 389:137\u2013139","journal-title":"Neurosci Lett"},{"key":"9207_CR10","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1002\/mds.20890","volume":"21","author":"R Marongiu","year":"2006","unstructured":"Marongiu R, Grezzi D, Ialongo T, Soleti F, Elia A, Cavone S, Albanese A, Altavista MC, Barone P, Brusa L, Cortelli P, Petrozzi L, Scaglione C, Stanzione P, Tinazzi M, Zeviani M, Dalla piccola B, Bentivoglio AR, Valente EM, Garavaglia B, Italian PD Study Group (2006) Frequency and phenotypes of LRRK2 G2019S mutation in Italian patients with Parkinson\u2019s disease. Mov Disord 21:1232\u20131235","journal-title":"Mov Disord"},{"key":"9207_CR11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.neuron.2004.10.023","volume":"44","author":"C Paisan-Ruiz","year":"2004","unstructured":"Paisan-Ruiz C, Jain S, Evans EW, Gilks WP, Simon J, van der Brug M, Lopez de Munain A, Aparicio S, Gil AM, Khan N, Johnson J, Martinez JR, Nicholl D, Carrera IM, Pena AS, de Silva R, Lees A, Marti-Masso JF, Perez-Tur J, Wood NW, Singleton AB (2004) Cloning of the gene containing mutations that cause PARK8-linked Parkinson\u2019s disease. Neuron 44:595\u2013600","journal-title":"Neuron"},{"key":"9207_CR12","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/376775a0","volume":"376","author":"EI Rogaev","year":"1995","unstructured":"Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T, Mar L, Sorbi S, Nacmias B, Piacentini S, Amaducci L, Chumakov I, Cohen D, Lannfelt L, Fraser PE, Rommens JM, St George-Hyslop PH (1995) Familial Alzheimer\u2019s disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer\u2019s disease type 3 gene. Nature 376:775\u2013778","journal-title":"Nature"},{"key":"9207_CR13","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","volume":"375","author":"R Sherrington","year":"1995","unstructured":"Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RT, Wasco W, Da Silva HAR, Haines JL, Pericak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH (1995) Cloning of a novel gene bearing missense mutations in early onset familial Alzheimer\u2019s disease. Nature 375:754\u2013760","journal-title":"Nature"},{"key":"9207_CR14","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10038-006-0105-2","volume":"52","author":"T Squillaro","year":"2007","unstructured":"Squillaro T, Cambi F, Ciacci G, Rossi S, Ulivelli M, Malandrini A, Mencarelli MA, Mari F, Renieri A, Ariani F (2007) Frequency of the LRRK2 G2019S mutation in Italian patients affected by Parkinson\u2019s disease. J Hum Genet 52:201\u2013204","journal-title":"J Hum Genet"},{"key":"9207_CR15","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","volume":"90","author":"WJ Strittmatter","year":"1993","unstructured":"Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD (1993) Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 90:1977\u20131981","journal-title":"Proc Natl Acad Sci USA"},{"key":"9207_CR16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s100720070075","volume":"21","author":"The Dementia Study Group of the Italian Neurological Society.","year":"2000","unstructured":"The Dementia Study Group of the Italian Neurological Society. (2000) Guidelines for the diagnosis of dementia and Alzheimer\u2019s disease. Ital J Neurol Sci 21:187\u2013194","journal-title":"Ital J Neurol Sci"},{"key":"9207_CR17","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.mad.2005.06.010","volume":"126","author":"M Toft","year":"2005","unstructured":"Toft M, Sando SB, Melquist S, Ross OA, White LR, Aasly JO, Farrer MJ (2005) LRRK2 mutations are not common in Alzheimer\u2019s disease. Mech Ageing Dev 126:1201\u20131205","journal-title":"Mech Ageing Dev"},{"key":"9207_CR18","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1001\/archneur.63.1.156","volume":"63","author":"CP Zabetian","year":"2006","unstructured":"Zabetian CP, Lauricella CJ, Tsuang DW, Leverenz JB, Schellenberg GD, Payami H (2006) Analysis of the LRRK2 G2019S mutation in Alzheimer Disease. Arch Neurol 63:156\u2013157","journal-title":"Arch Neurol"},{"key":"9207_CR19","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1373\/clinchem.2005.054924","volume":"51","author":"L Zhou","year":"2005","unstructured":"Zhou L, Wang L, Palais R, Pryor R, Wittwer CT (2005) High-resolution DNA melting analysis for simultaneous mutation scanning and genotyping in solution. Clin Chem 51:1770\u20131777","journal-title":"Clin Chem"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-007-9207-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10571-007-9207-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-007-9207-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T18:06:28Z","timestamp":1559239588000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10571-007-9207-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,11]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["9207"],"URL":"https:\/\/doi.org\/10.1007\/s10571-007-9207-4","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,11]]}}}