{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:08:50Z","timestamp":1791288530601,"version":"4.3.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2008,1,15]],"date-time":"2008-01-15T00:00:00Z","timestamp":1200355200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1007\/s10571-007-9259-5","type":"journal-article","created":{"date-parts":[[2008,1,14]],"date-time":"2008-01-14T12:57:55Z","timestamp":1200315475000},"page":"331-342","source":"Crossref","is-referenced-by-count":48,"title":["Stress Upregulates TPH1 but not TPH2 mRNA in the Rat Dorsal Raphe Nucleus: Identification of Two TPH2 mRNA Splice Variants"],"prefix":"10.1007","volume":"28","author":[{"given":"Nashat","family":"Abumaria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adema","family":"Ribic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Anacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Fl\u00fcgge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,1,15]]},"reference":[{"key":"9259_CR1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10571-006-9024-1","volume":"26","author":"N Abumaria","year":"2006","unstructured":"Abumaria N, Rygula R, Havemann-Reinecke U, R\u00fcther E, Bodemer W, Roos C, Fl\u00fcgge G (2006) Identification of genes regulated by chronic social stress in the rat dorsal raphe nucleus. Cell Mol Neurobiol 26:145\u2013162","journal-title":"Cell Mol Neurobiol"},{"key":"9259_CR2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.euroneuro.2006.08.009","volume":"17","author":"N Abumaria","year":"2007","unstructured":"Abumaria N, Rygula R, Hiemke C, Fuchs E, Havemann-Reinecke U, R\u00fcther E, Fl\u00fcgge G (2007) Effect of chronic citalopram on serotonin-related and stress-regulated genes in the dorsal raphe nucleus of the rat. Eur Neuropsychopharmacol 17:417\u2013429","journal-title":"Eur Neuropsychopharmacol"},{"key":"9259_CR3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0079-6123(02)36037-0","volume":"136","author":"V Arango","year":"2002","unstructured":"Arango V, Underwood MD, Mann JJ (2002) Serotonin brain circuits involved in major depression and suicide. Prog Brain Res 136:443\u2013453","journal-title":"Prog Brain Res"},{"key":"9259_CR4","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1046\/j.1471-4159.1999.0722065.x","volume":"72","author":"MC Austin","year":"1999","unstructured":"Austin MC, O\u2019Donnell SM (1999) Regional distribution and cellular expression of tryptophan hydroxylase messenger RNA in postmortem human brainstem and pineal gland. J Neurochem 72:2065\u20132073","journal-title":"J Neurochem"},{"key":"9259_CR5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0006-8993(74)90553-8","volume":"78","author":"EC Azmitia Jr","year":"1974","unstructured":"Azmitia EC Jr, McEwen BS (1974) Adrenalcortical influence on rat brain tryptophan hydroxylase activity. Brain Res 78:291\u2013302","journal-title":"Brain Res"},{"key":"9259_CR6","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1471-4159.1976.tb10407.x","volume":"27","author":"EC Azmitia","year":"1976","unstructured":"Azmitia EC, McEwen BS (1976) Early response of rat brain tryptophan hydroxylase activity to cycloheximide, puromycin and corticosterone. J Neurochem 27:773\u2013778","journal-title":"J Neurochem"},{"key":"9259_CR7","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/sj.npp.1300897","volume":"31","author":"H Bach-Mizrachi","year":"2006","unstructured":"Bach-Mizrachi H, Underwood MD, Kassir SA, Bakalian MJ, Sibille E, Tamir H, Mann JJ, Arango V (2006) Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. Neuropsychopharmacol 31:814\u2013824","journal-title":"Neuropsychopharmacol"},{"key":"9259_CR8","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0006-8993(89)91193-1","volume":"482","author":"MC Boadle-Biber","year":"1989","unstructured":"Boadle-Biber MC, Corley KC, Graves L, Phan TH, Rosecrans J (1989) Increase in the activity of tryptophan hydroxylase from cortex and midbrain of male Fischer 344 rats in response to acute or repeated sound stress. Brain Res 482:306\u2013316","journal-title":"Brain Res"},{"key":"9259_CR9","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1074\/jbc.270.8.3748","volume":"270","author":"S Boularand","year":"1995","unstructured":"Boularand S, Darmon MC, Mallet J (1995a) The human tryptophan hydroxylase gene. An unusual splicing complexity in the 5\u2032-untranslated region. J Biol Chem 270:3748\u20133756","journal-title":"J Biol Chem"},{"key":"9259_CR10","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1074\/jbc.270.8.3757","volume":"270","author":"S Boularand","year":"1995","unstructured":"Boularand S, Darmon MC., Ravassard P, Mallet J (1995b) Characterization of the human tryptophan hydroxylase gene promoter. Transcriptional regulation by cAMP requires a new motif distinct from the cAMP-responsive element. J Biol Chem 270:3757\u20133764","journal-title":"J Biol Chem"},{"key":"9259_CR11","doi-asserted-by":"crossref","unstructured":"Brown SM, Peet E, Manuck SB, Williamson DE, Dahl RE, Ferrell RE, Hariri AR (2005) A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Mol Psychiatry 10: 805, 884\u2013888","DOI":"10.1038\/sj.mp.4001716"},{"key":"9259_CR13","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1046\/j.1471-4159.2002.00989.x","volume":"82","author":"F Chamas","year":"2002","unstructured":"Chamas F, Sabban EL (2002) Role of the 5\u2032 untranslated region (UTR) in the tissue-specific regulation of rat tryptophan hydroxylase gene expression by stress. J Neurochem 82:645\u2013654","journal-title":"J Neurochem"},{"key":"9259_CR12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0304-3940(99)00340-7","volume":"267","author":"F Chamas","year":"1999","unstructured":"Chamas F, Serova L, Sabban EL (1999) Tryptophan hydroxylase mRNA levels are elevated by repeated immobilization stress in rat raphe nuclei but not in pineal gland. Neurosci Lett 267:157\u2013160","journal-title":"Neurosci Lett"},{"key":"9259_CR14","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0006-3223(03)00788-1","volume":"55","author":"FM Chamas","year":"2004","unstructured":"Chamas FM, Underwood MD, Arango V, Serova L, Kassir SA, Mann JJ, Sabban EL (2004) Immobilization stress elevates tryptophan hydroxylase mRNA and protein in the rat raphe nuclei. Biol Psychiatry 55:278\u2013283","journal-title":"Biol Psychiatry"},{"key":"9259_CR15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/026988110001400203","volume":"14","author":"F Chaouloff","year":"2000","unstructured":"Chaouloff F (2000) Serotonin, stress and corticoids. J Psychopharmacol 14:139\u2013151","journal-title":"J Psychopharmacol"},{"key":"9259_CR16","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/sj.mp.4001870","volume":"11","author":"GL Chen","year":"2006","unstructured":"Chen GL, Novak MA, Hakim S, Xie Z, Miller GM (2006) Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in\u00a0vitro gene expression. Mol Psychiatry 11:914\u2013928","journal-title":"Mol Psychiatry"},{"key":"9259_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/aja.1001780102","volume":"178","author":"AK Christensen","year":"1987","unstructured":"Christensen AK, Kahn LE, Bourne CM (1987) Circular polysomes predominate on the rough endoplasmic reticulum of somatotropes and mammotropes in the rat anterior pituitary. Am J Anat 178:1\u201310","journal-title":"Am J Anat"},{"key":"9259_CR18","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.biopsych.2005.01.013","volume":"57","author":"JA Clark","year":"2005","unstructured":"Clark JA, Pai LY, Flick RB, Rohrer SP (2005) Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus. Biol Psychiatry 57:943\u2013946","journal-title":"Biol Psychiatry"},{"key":"9259_CR19","doi-asserted-by":"crossref","unstructured":"Clark JA, Flick RB, Pai LY et\u00a0al (2007) Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57\/Bl6 mice. Mol Psychiatry; doi: 10.1038\/sj.mp.4002041","DOI":"10.1038\/sj.mp.4002041"},{"key":"9259_CR20","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1073\/pnas.2233056100","volume":"100","author":"F Cote","year":"2003","unstructured":"Cote F, Thevenot E, Fligny C et\u00a0al (2003) Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc Natl Acad Sci USA 100:13525\u201313530","journal-title":"Proc Natl Acad Sci USA"},{"key":"9259_CR22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/10253899709014734","volume":"2","author":"ER Kloet de","year":"1997","unstructured":"de Kloet ER (1997) Why dexamethasone poorly penetrates in brain. Stress 2:13\u201320","journal-title":"Stress"},{"key":"9259_CR21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0306-4530(87)90040-0","volume":"12","author":"ER Kloet de","year":"1987","unstructured":"de Kloet ER, Reul JM (1987) Feedback action and tonic influence of corticosteroids on brain function: a concept arising from the heterogeneity of brain receptor systems. Psychoneuroendocrinology 12:83\u2013105","journal-title":"Psychoneuroendocrinology"},{"key":"9259_CR23","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/jnr.490240412","volume":"24","author":"S Dumas","year":"1989","unstructured":"Dumas S, Darmon MC, Delort J, Mallet J (1989) Differential control of tryptophan hydroxylase expression in raphe and in pineal gland: evidence for a role of translation efficiency. J Neurosci Res 24:537\u2013547","journal-title":"J Neurosci Res"},{"key":"9259_CR24","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.pbb.2006.08.004","volume":"85","author":"NN Dygalo","year":"2006","unstructured":"Dygalo NN, Shishkina GT, Kalinina TS, Yudina AM, Ovchinnikova ES (2006) Effect of repeated treatment with fluoxetine on tryptophan hydroxylase-2 gene expression in the rat brainstem. Pharmacol Biochem Behav 85:220\u2013227","journal-title":"Pharmacol Biochem Behav"},{"key":"9259_CR25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00041444-200010010-00004","volume":"10","author":"T Geijer","year":"2000","unstructured":"Geijer T, Frisch A, Persson ML, et\u00a0al (2000) Search for association between suicide attempt and serotonergic polymorphisms. Psychiatr Genet 10:19\u201326","journal-title":"Psychiatr Genet"},{"key":"9259_CR26","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.biopsych.2005.07.034","volume":"59","author":"R Gizatullin","year":"2006","unstructured":"Gizatullin R, Zaboli G, Jonsson EG, Asberg M, Leopardi R (2006) Haplotype analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression. Biol Psychiatry 59:295\u2013300","journal-title":"Biol Psychiatry"},{"key":"9259_CR27","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.biopsych.2005.01.014","volume":"57","author":"C Gundlah","year":"2005","unstructured":"Gundlah C, Alves SE, Clark JA, Pai LY, Schaeffer JM, Rohrer SP (2005) Estrogen receptor-beta regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe. Biol Psychiatry 57:938\u2013942","journal-title":"Biol Psychiatry"},{"key":"9259_CR28","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/978-1-4684-3860-4_13","volume":"133","author":"M Hamon","year":"1981","unstructured":"Hamon M, Bourgoin S, Artaud F, Nelson D (1981) Regulatory properties of neuronal tryptophan hydroxylase. Adv Exp Med Biol 133:231\u2013251","journal-title":"Adv Exp Med Biol"},{"key":"9259_CR29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0169-328X(94)90126-0","volume":"24","author":"SO Huh","year":"1994","unstructured":"Huh SO, Park DH, Cho JY, Joh TH, Son JH (1994) A 6.1 kb 5\u2032 upstream region of the mouse tryptophan hydroxylase gene directs expression of E. coli lacZ to major serotonergic brain regions and pineal gland in transgenic mice. Mol Brain Res 24:145\u2013152","journal-title":"Mol Brain Res"},{"key":"9259_CR30","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1176\/ajp.156.6.837","volume":"156","author":"KS Kendler","year":"1999","unstructured":"Kendler KS, Karkowski LM, Prescott CA (1999) Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry 156:837\u2013841","journal-title":"Am J Psychiatry"},{"key":"9259_CR31","doi-asserted-by":"crossref","first-page":"7728","DOI":"10.1523\/JNEUROSCI.20-20-07728.2000","volume":"20","author":"CA Lowry","year":"2000","unstructured":"Lowry CA, Rodda JE, Lightman SL, Ingram CD (2000) Corticotropin-releasing factor increases in\u00a0vitro firing rates of serotonergic neurons in the rat dorsal raphe nucleus: evidence for activation of a topographically organized mesolimbocortical serotonergic system. J Neurosci 20:7728\u20137736","journal-title":"J Neurosci"},{"key":"9259_CR32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0306-4522(95)00256-I","volume":"69","author":"AM Magarinos","year":"1995","unstructured":"Magarinos AM, McEwen BS (1995) Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: comparison of stressors. Neuroscience 69:83\u201388","journal-title":"Neuroscience"},{"key":"9259_CR33","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35085068","volume":"2","author":"B Mayr","year":"2001","unstructured":"Mayr B, Montminy M (2001) Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2:599\u2013609","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9259_CR34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1749-6632.1998.tb09546.x","volume":"840","author":"BS McEwen","year":"1998","unstructured":"McEwen BS (1998) Stress, adaptation, and disease. Allostasis and allostatic load. Ann N Y Acad Sci 840:33\u201344","journal-title":"Ann N Y Acad Sci"},{"key":"9259_CR35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1471-4159.2004.02850.x","volume":"92","author":"J McKinney","year":"2005","unstructured":"McKinney J, Knappskog PM, Haavik J (2005) Different properties of the central and peripheral forms of human tryptophan hydroxylase. J Neurochem 92:311\u2013320","journal-title":"J Neurochem"},{"key":"9259_CR36","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0006-8993(00)02787-6","volume":"880","author":"H Meyer","year":"2000","unstructured":"Meyer H, Palchaudhuri M, Scheinin M, Fl\u00fcgge G (2000) Regulation of alpha(2A)-adrenoceptor expression by chronic stress in neurons of the brain stem. Brain Res 880:147\u2013158","journal-title":"Brain Res"},{"key":"9259_CR37","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1523\/JNEUROSCI.1835-05.2006","volume":"26","author":"K Nakamura","year":"2006","unstructured":"Nakamura K, Sugawara Y, Sawabe K, et\u00a0al (2006) Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. J Neurosci 26:530\u2013534","journal-title":"J Neurosci"},{"key":"9259_CR38","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.55.7.593","volume":"55","author":"DA Nielsen","year":"1998","unstructured":"Nielsen DA, Virkkunen M, Lappalainen J, Eggert M, Brown GL, Long JC, Goldman D, Linnoila M (1998) A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry 55:593\u2013602","journal-title":"Arch Gen Psychiatry"},{"key":"9259_CR39","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0006-8993(73)90290-4","volume":"59","author":"M Palkovits","year":"1973","unstructured":"Palkovits M (1973) Isolated removal of hypothalamic or other brain nuclei of the rat. Brain Res 59:449\u2013450","journal-title":"Brain Res"},{"key":"9259_CR40","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.biopsych.2003.09.002","volume":"55","author":"PD Patel","year":"2004","unstructured":"Patel PD, Pontrello C, Burke S (2004) Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Biol Psychiatry 55:428\u2013433","journal-title":"Biol Psychiatry"},{"key":"9259_CR41","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1093\/nar\/gng073","volume":"31","author":"SN Peirson","year":"2003","unstructured":"Peirson SN, Butler JN, Foster RG (2003) Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis. Nucleic Acids Res 31:e73","journal-title":"Nucleic Acids Res"},{"key":"9259_CR42","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1006\/abio.1996.9916","volume":"245","author":"KM Ririe","year":"1997","unstructured":"Ririe KM, Rasmussen RP, Wittwer CT (1997) Product differentiation by analysis of DNA melting curves during the polymerase chain reaction. Anal Biochem 245:154\u2013160","journal-title":"Anal Biochem"},{"key":"9259_CR43","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0968-0004(97)01051-7","volume":"22","author":"AB Sachs","year":"1997","unstructured":"Sachs AB, Buratowski S (1997) Common themes in translational and transcriptional regulation. Trends Biochem Sci 22:189\u2013192","journal-title":"Trends Biochem Sci"},{"key":"9259_CR44","first-page":"55","volume":"21","author":"RM Sapolsky","year":"2000","unstructured":"Sapolsky RM, Romero LM, Munck AU (2000) How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 21:55\u201389","journal-title":"Endocr Rev"},{"key":"9259_CR45","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0006-8993(90)90898-L","volume":"516","author":"VB Singh","year":"1990","unstructured":"Singh VB, Corley KC, Phan TH, Boadle-Biber MC (1990) Increases in the activity of tryptophan hydroxylase from rat cortex and midbrain in response to acute or repeated sound stress are blocked by adrenalectomy and restored by dexamethasone treatment. Brain Res 516:66\u201376","journal-title":"Brain Res"},{"key":"9259_CR46","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1046\/j.1471-4159.2003.01959.x","volume":"86","author":"D Sugden","year":"2003","unstructured":"Sugden D (2003) Comparison of circadian expression of tryptophan hydroxylase isoform mRNAs in the rat pineal gland using real-time PCR. J Neurochem 86:1308\u20131311","journal-title":"J Neurochem"},{"key":"9259_CR47","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1111\/j.1471-4159.2007.04664.x","volume":"102","author":"K Tenner","year":"2007","unstructured":"Tenner K, Walther D, Bader M (2007) Influence of human tryptophan hydroxylase 2 N- and C-terminus on enzymatic activity and oligomerization. J Neurochem 102:1887\u20131894","journal-title":"J Neurochem"},{"key":"9259_CR48","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.1078197","volume":"299","author":"DJ Walther","year":"2003","unstructured":"Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H, Bader M (2003) Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299:76","journal-title":"Science"},{"key":"9259_CR49","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1046\/j.1471-4159.1998.71041769.x","volume":"71","author":"GA Wang","year":"1998","unstructured":"Wang GA, Coon SL, Kaufman S (1998) Alternative splicing at the 3\u2032-cDNA of human tryptophan hydroxylase. J Neurochem 71:1769\u20131772","journal-title":"J Neurochem"},{"key":"9259_CR50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0006-8993(80)90319-4","volume":"191","author":"L Wiklund","year":"1980","unstructured":"Wiklund L, Bjorklund A (1980) Mechanisms of regrowth in the bulbospinal serotonin system following 5,6-dihydroxytryptamine induced axotomy. II. Fluorescence histochemical observations. Brain Res 191:109\u2013127","journal-title":"Brain Res"},{"key":"9259_CR51","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.biopsych.2006.03.033","volume":"60","author":"G Zaboli","year":"2006","unstructured":"Zaboli G, Jonsson EG, Gizatullin R, Asberg M, Leopardi R (2006) Tryptophan hydroxylase-1 gene variants associated with schizophrenia. Biol Psychiatry 60:563\u2013569","journal-title":"Biol. Psychiatry"},{"key":"9259_CR52","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1097540","volume":"305","author":"X Zhang","year":"2004","unstructured":"Zhang X, Beaulieu JM, Sotnikova TD, Gainetdinov RR, Caron MG (2004) Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305:217","journal-title":"Science"},{"key":"9259_CR53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuron.2004.12.014","volume":"45","author":"X Zhang","year":"2005","unstructured":"Zhang X, Gainetdinov RR, Beaulieu JM, Sotnikova TD, Burch LH, Williams RB, Schwartz DA, Krishnan KR, Caron MG (2005) Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45:11\u201316","journal-title":"Neuron"},{"key":"9259_CR54","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1001\/archpsyc.62.10.1109","volume":"62","author":"Z Zhou","year":"2005","unstructured":"Zhou Z, Roy A, Lipsky R, Kuchipudi K, Zhu G, Taubman J, Enoch MA, Virkkunen M, Goldman D (2005) Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. Arch Gen Psychiatry 62:1109\u20131118","journal-title":"Arch Gen Psychiatry"},{"key":"9259_CR55","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.euroneuro.2003.10.002","volume":"14","author":"P Zill","year":"2004","unstructured":"Zill P, Buttner A, Eisenmenger W, Bondy B, Ackenheil M (2004a) Regional mRNA expression of a second tryptophan hydroxylase isoform in postmortem tissue samples of two human brains. Eur Neuropsychopharmacol 14:282\u2013284","journal-title":"Eur Neuropsychopharmacol"},{"key":"9259_CR56","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.biopsych.2004.07.015","volume":"56","author":"P Zill","year":"2004","unstructured":"Zill P, Buttner A, Eisenmenger W, M\u00f6ller HJ, Bondy B, Ackenheil M (2004b) Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol Psychiatry 56:581\u2013586","journal-title":"Biol Psychiatry"},{"key":"9259_CR57","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jpsychires.2005.05.004","volume":"41","author":"P Zill","year":"2007","unstructured":"Zill P, Buttner A, Eisenmenger W, M\u00f6ller HJ, Ackenheil M, Bondy B (2007) Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study. J Psychiatr Res 41:168\u2013173","journal-title":"J Psychiatr Res"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-007-9259-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10571-007-9259-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-007-9259-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T14:06:31Z","timestamp":1559225191000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10571-007-9259-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,15]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["9259"],"URL":"https:\/\/doi.org\/10.1007\/s10571-007-9259-5","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,15]]}}}