{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:39:52Z","timestamp":1790980792323,"version":"4.1.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2011,12,25]],"date-time":"2011-12-25T00:00:00Z","timestamp":1324771200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1007\/s10571-011-9784-0","type":"journal-article","created":{"date-parts":[[2011,12,24]],"date-time":"2011-12-24T04:29:13Z","timestamp":1324700953000},"page":"815-828","source":"Crossref","is-referenced-by-count":34,"title":["Assessing Behavioural Effects of Chronic HPA Axis Activation Using Conditional CRH-Overexpressing Mice"],"prefix":"10.1007","volume":"32","author":[{"given":"Nina","family":"Dedic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chadi","family":"Touma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristoph P.","family":"Romanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Schieven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"K\u00fchne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ableitner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Holsboer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.","family":"Deussing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,12,25]]},"reference":[{"key":"9784_CR1","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1093\/nar\/25.9.1766","volume":"25","author":"K Akagi","year":"1997","unstructured":"Akagi K, Sandig V, Vooijs M, Van der Valk M, Giovannini M, Strauss M, Berns A (1997) Cre-mediated somatic site-specific recombination in mice. Nucl Acids Res 25:1766\u20131773","journal-title":"Nucl Acids Res"},{"key":"9784_CR2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1101\/lm.918309","volume":"16","author":"JM Andreano","year":"2009","unstructured":"Andreano JM, Cahill L (2009) Sex influences on the neurobiology of learning and memory. Learn Mem 16:248\u2013266","journal-title":"Learn Mem"},{"key":"9784_CR3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1037\/0735-7044.120.2.249","volume":"120","author":"P Ardayfio","year":"2006","unstructured":"Ardayfio P, Kim KS (2006) Anxiogenic-like effect of chronic corticosterone in the light\u2013dark emergence task in mice. Behav Neurosci 120:249\u2013256","journal-title":"Behav Neurosci"},{"key":"9784_CR4","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1210\/en.2010-0101","volume":"151","author":"HC Atkinson","year":"2010","unstructured":"Atkinson HC, Leggett JD, Wood SA, Castrique ES, Kershaw YM, Lightman SL (2010) Regulation of the hypothalamic-pituitary-adrenal axis circadian rhythm by endocannabinoids is sexually diergic. Endocrinology 151:3720\u20133727","journal-title":"Endocrinology"},{"key":"9784_CR5","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0014-2999(01)01148-7","volume":"424","author":"LA Brotto","year":"2001","unstructured":"Brotto LA, Gorzalka BB, Barr AM (2001) Paradoxical effects of chronic corticosterone on forced swim behaviours in aged male and female rats. Eur J Pharmacol 424:203\u2013209","journal-title":"Eur J Pharmacol"},{"key":"9784_CR6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3109\/10673229809000307","volume":"5","author":"ES Brown","year":"1998","unstructured":"Brown ES, Suppes T (1998) Mood symptoms during corticosteroid therapy: a review. Harv Rev Psychiatry 5:239\u2013246","journal-title":"Harv Rev Psychiatry"},{"key":"9784_CR7","first-page":"109","volume":"13","author":"CM Celano","year":"2011","unstructured":"Celano CM, Freudenreich O, Fernandez-Robles C, Stern TA, Caro MA, Huffman JC (2011) Depressogenic effects of medications: a review. Dialogues. Clin Neurosci 13:109\u2013125","journal-title":"Clin Neurosci"},{"key":"9784_CR8","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0196-9781(01)00386-2","volume":"22","author":"SC Coste","year":"2001","unstructured":"Coste SC, Murray SE, Stenzel-Poore MP (2001) Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress. Peptides 22:733\u2013741","journal-title":"Peptides"},{"key":"9784_CR9","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuron.2009.04.017","volume":"62","author":"DJ David","year":"2009","unstructured":"David DJ, Samuels BA, Rainer Q, Wang JW, Marsteller D, Mendez I, Drew M, Craig DA, Guiard BP, Guilloux JP, Artymyshyn RP, Gardier AM, Gerald C, Antonijevic IA, Leonardo ED, Hen R (2009) Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety\/depression. Neuron 62:479\u2013493","journal-title":"Neuron"},{"key":"9784_CR10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrn1683","volume":"6","author":"ER Kloet de","year":"2005","unstructured":"de Kloet ER, Joels M, Holsboer F (2005) Stress and the brain: from adaptation to disease. Nat Rev Neurosci 6:463\u2013475","journal-title":"Nat Rev Neurosci"},{"key":"9784_CR11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.crvi.2005.01.001","volume":"328","author":"JM Deussing","year":"2005","unstructured":"Deussing JM, Wurst W (2005) Dissecting the genetic effect of the CRH system on anxiety and stress-related behaviour. Comptes Rendus Biologies 328:199\u2013212","journal-title":"Comptes Rendus Biologies"},{"key":"9784_CR12","first-page":"123","volume":"16","author":"A Dirks","year":"2001","unstructured":"Dirks A, Groenink L, Verdouw MP, Schipholt M, Jvd Gugten, Hijzen T, Olivier B (2001) Behavioural analysis of transgenic mice overexpressing corticotropin-releasing hormone in paradigms emulating aspects of stress, anxiety, and depression. Int J Comp Psychology 16:123\u2013135","journal-title":"Int J Comp Psychology"},{"key":"9784_CR13","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1046\/j.1460-9568.2002.02245.x","volume":"16","author":"A Dirks","year":"2002","unstructured":"Dirks A, Groenink L, Bouwknecht JA, Hijzen TH, Van Der GJ, Ronken E, Verbeek JS, Veening JG, Dederen PJ, Korosi A, Schoolderman LF, Roubos EW, Olivier B (2002a) Overexpression of corticotropin-releasing hormone in transgenic mice and chronic stress-like autonomic and physiological alterations. Eur J Neurosci 16:1751\u20131760","journal-title":"Eur J Neurosci"},{"key":"9784_CR14","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0006-3223(01)01323-3","volume":"51","author":"A Dirks","year":"2002","unstructured":"Dirks A, Groenink L, Schipholt MI, Van Der GJ, Hijzen TH, Geyer MA, Olivier B (2002b) Reduced startle reactivity and plasticity in transgenic mice overexpressing corticotropin-releasing hormone. Biol Psychiatry 51:583\u2013590","journal-title":"Biol Psychiatry"},{"key":"9784_CR15","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.neuroscience.2004.04.044","volume":"126","author":"G Drossopoulou","year":"2004","unstructured":"Drossopoulou G, Antoniou K, Kitraki E, Papathanasiou G, Papalexi E, Dalla C, Papadopoulou-Daifoti Z (2004) Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats. Neuroscience 126:849\u2013857","journal-title":"Neuroscience"},{"key":"9784_CR16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1471-2202-8-63","volume":"8","author":"G Erdmann","year":"2007","unstructured":"Erdmann G, Sch\u00fctz G, Berger S (2007) Inducible gene inactivation in neurons of the adult mouse forebrain. BMC Neurosci 8:63","journal-title":"BMC Neurosci"},{"key":"9784_CR17","doi-asserted-by":"crossref","unstructured":"Flandreau EI, Ressler KJ, Owens MJ, Nemeroff CB (2011) Chronic overexpression of corticotropin-releasing factor from the central amygdala produces HPA axis hyperactivity and behaviorial anxiety associated with gene-expression changes in the hippocampus and paraventricular nucleus of the hypothalamus. Psychoneuroendocrinology","DOI":"10.1016\/j.psyneuen.2011.04.014"},{"key":"9784_CR18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-2869.1994.tb00110.x","volume":"3","author":"E Friess","year":"1994","unstructured":"Friess E, Bardeleben V, Wiedemann K, Lauer CJ, Holsboer F (1994) Effects of pulsatile cortisol infusion on sleep-EEG and nocturnal growth hormone release in healthy men. J Sleep Res 3:73\u201379","journal-title":"J Sleep Res"},{"key":"9784_CR19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ejphar.2007.11.075","volume":"583","author":"JP Gallagher","year":"2008","unstructured":"Gallagher JP, Orozco-Cabal LF, Liu J, Shinnick-Gallagher P (2008) Synaptic physiology of central CRH system. Eur J Pharmacol 583:215\u2013225","journal-title":"Eur J Pharmacol"},{"key":"9784_CR20","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.psyneuen.2010.05.006","volume":"35","author":"C Garcia-Caceres","year":"2010","unstructured":"Garcia-Caceres C, Lagunas N, Calmarza-Font I, Azcoitia I, Diz-Chaves Y, Garcia-Segura LM, Baquedano E, Frago LM, Argente J, Chowen JA (2010) Gender differences in the long-term effects of chronic prenatal stress on the HPA axis and hypothalamic structure in rats. Psychoneuroendocrinology 35:1525\u20131535","journal-title":"Psychoneuroendocrinology"},{"key":"9784_CR21","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0091-3057(00)00384-1","volume":"67","author":"C Garcia-Lecumberri","year":"2000","unstructured":"Garcia-Lecumberri C, Ambrosio E (2000) Differential effect of low doses of intracerebroventricular corticotropin-releasing factor in forced swimming test. Pharmacol Biochem Behav 67:519\u2013525","journal-title":"Pharmacol Biochem Behav"},{"key":"9784_CR22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.biopsych.2007.07.016","volume":"63","author":"SL Gourley","year":"2008","unstructured":"Gourley SL, Wu FJ, Kiraly DD, Ploski JE, Kedves AT, Duman RS, Taylor JR (2008) Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression. Biol Psychiatry 63:353\u2013359","journal-title":"Biol Psychiatry"},{"key":"9784_CR23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbr.2004.05.013","volume":"156","author":"A Gregus","year":"2005","unstructured":"Gregus A, Wintink AJ, Davis AC, Kalynchuk LE (2005) Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats. Behav Brain Res 156:105\u2013114","journal-title":"Behav Brain Res"},{"key":"9784_CR24","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0006-3223(02)01334-3","volume":"51","author":"L Groenink","year":"2002","unstructured":"Groenink L, Dirks A, Verdouw PM, Schipholt M, Veening JG, Van Der GJ, Olivier B (2002) HPA axis dysregulation in mice overexpressing corticotropin releasing hormone. Biol Psychiatry 51:875\u2013881","journal-title":"Biol Psychiatry"},{"key":"9784_CR25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0014-2999(03)01281-0","volume":"463","author":"L Groenink","year":"2003","unstructured":"Groenink L, Pattij T, De JR, Van Der GJ, Oosting RS, Dirks A, Olivier B (2003) 5-HT1A receptor knockout mice and mice overexpressing corticotropin-releasing hormone in models of anxiety. Eur J Pharmacol 463:185\u2013197","journal-title":"Eur J Pharmacol"},{"key":"9784_CR26","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.neuropharm.2011.07.041","volume":"62","author":"J Hartmann","year":"2011","unstructured":"Hartmann J, Wagner KV, Liebl C, Scharf SH, Wang XD, Wolf M, Hausch F, Rein T, Schmidt U, Touma C, Cheung-Flynn J, Cox MB, Smith DF, Holsboer F, Muller MB, Schmidt MV (2011) The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress. Neuropharmacology 62:332\u2013339","journal-title":"Neuropharmacology"},{"key":"9784_CR27","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1054\/npep.1999.0047","volume":"33","author":"SC Heinrichs","year":"1999","unstructured":"Heinrichs SC, Richard D (1999) The role of corticotropin-releasing factor and urocortin in the modulation of ingestive behavior. Neuropeptides 33:350\u2013359","journal-title":"Neuropeptides"},{"key":"9784_CR28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0006-8993(93)91771-J","volume":"611","author":"SC Heinrichs","year":"1993","unstructured":"Heinrichs SC, Menzaghi F, Pich EM, Hauger RL, Koob GF (1993) Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y. Brain Res 611:18\u201324","journal-title":"Brain Res"},{"key":"9784_CR29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0306-4530(97)00030-9","volume":"22","author":"SC Heinrichs","year":"1997","unstructured":"Heinrichs SC, Min H, Tamraz S, Carmouche M, Boehme SA, Vale WW (1997) Anti-sexual and anxiogenic behavioral consequences of corticotropin-releasing factor overexpression are centrally mediated. Psychoneuroendocrinology 22:215\u2013224","journal-title":"Psychoneuroendocrinology"},{"key":"9784_CR30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1037\/0735-7044.121.1.11","volume":"121","author":"S Het","year":"2007","unstructured":"Het S, Wolf OT (2007) Mood changes in response to psychosocial stress in healthy young women: effects of pretreatment with cortisol. Behav Neurosci 121:11\u201320","journal-title":"Behav Neurosci"},{"key":"9784_CR31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0022-3956(98)90056-5","volume":"33","author":"F Holsboer","year":"1999","unstructured":"Holsboer F (1999) The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. J Psychiatr Res 33:181\u2013214","journal-title":"J Psychiatr Res"},{"key":"9784_CR32","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/mp.2009.46","volume":"15","author":"M Kimura","year":"2010","unstructured":"Kimura M, Muller-Preuss P, Lu A, Wiesner E, Flachskamm C, Wurst W, Holsboer F, Deussing JM (2010) Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep. Mol Psychiatry 15:154\u2013165","journal-title":"Mol Psychiatry"},{"key":"9784_CR33","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1523\/JNEUROSCI.4470-09.2010","volume":"30","author":"BJ Kolber","year":"2010","unstructured":"Kolber BJ, Boyle MP, Wieczorek L, Kelley CL, Onwuzurike CC, Nettles SA, Vogt SK, Muglia LJ (2010) Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice. J Neurosci 30:2571\u20132581","journal-title":"J Neurosci"},{"key":"9784_CR34","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1176\/ajp.141.11.1365","volume":"141","author":"MT Lowy","year":"1984","unstructured":"Lowy MT, Reder AT, Antel JP, Meltzer HY (1984) Glucocorticoid resistance in depression: the dexamethasone suppression test and lymphocyte sensitivity to dexamethasone. Am J Psychiatry 141:1365\u20131370","journal-title":"Am J Psychiatry"},{"key":"9784_CR35","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/mp.2008.51","volume":"13","author":"A Lu","year":"2008","unstructured":"Lu A, Steiner MA, Whittle N, Vogl AM, Walser SM, Ableitner M, Refojo D, Ekker M, Rubenstein JL, Stalla GK, Singewald N, Holsboer F, Wotjak CT, Wurst W, Deussing JM (2008) Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. Mol Psychiatry 13:1028\u20131042","journal-title":"Mol Psychiatry"},{"key":"9784_CR36","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0006-8993(93)90431-L","volume":"618","author":"F Menzaghi","year":"1993","unstructured":"Menzaghi F, Heinrichs SC, Pich EM, Tilders FJ, Koob GF (1993) Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food intake induced by neuropeptide Y. Brain Res 618:76\u201382","journal-title":"Brain Res"},{"key":"9784_CR37","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/nn1123","volume":"6","author":"MB Muller","year":"2003","unstructured":"Muller MB, Zimmermann S, Sillaber I, Hagemeyer TP, Deussing JM, Timpl P, Kormann MS, Droste SK, Kuhn R, Reul JM, Holsboer F, Wurst W (2003) Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat Neurosci 6:1100\u20131107","journal-title":"Nat Neurosci"},{"key":"9784_CR38","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2008.01.014","volume":"583","author":"F Murray","year":"2008","unstructured":"Murray F, Smith DW, Hutson PH (2008) Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice. Eur J Pharmacol 583:115\u2013127","journal-title":"Eur J Pharmacol"},{"key":"9784_CR39","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1126\/science.6334362","volume":"226","author":"CB Nemeroff","year":"1984","unstructured":"Nemeroff CB, Widerlov E, Bissette G, Walleus H, Karlsson I, Eklund K, Kilts CD, Loosen PT, Vale W (1984) Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 226:1342\u20131344","journal-title":"Science"},{"key":"9784_CR40","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.physbeh.2007.12.011","volume":"94","author":"AG Nieuwenhuizen","year":"2008","unstructured":"Nieuwenhuizen AG, Rutters F (2008) The hypothalamic\u2013pituitary\u2013adrenal-axis in the regulation of energy balance. Physiol Behav 94:169\u2013177","journal-title":"Physiol Behav"},{"key":"9784_CR41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psychres.2003.12.010","volume":"126","author":"F Peeters","year":"2004","unstructured":"Peeters F, Nicolson NA, Berkhof J (2004) Levels and variability of daily life cortisol secretion in major depression. Psychiatry Res 126:1\u201313","journal-title":"Psychiatry Res"},{"key":"9784_CR42","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1126\/science.1202107","volume":"333","author":"D Refojo","year":"2011","unstructured":"Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl AM, Dedic N, Schumacher M, von Wolff G, Avrabos C, Touma C, Engblom D, Schutz G, Nave KA, Eder M, Wotjak CT, Sillaber I, Holsboer F, Wurst W, Deussing JM (2011) Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science 333:1903\u20131907","journal-title":"Science"},{"key":"9784_CR43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000063575","volume":"46","author":"M Reuter","year":"2002","unstructured":"Reuter M (2002) Impact of cortisol on emotions under stress and nonstress conditions: a pharmacopsychological approach. Neuropsychobiology 46:41\u201348","journal-title":"Neuropsychobiology"},{"key":"9784_CR44","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0361-9230(99)00191-4","volume":"50","author":"RW Rhees","year":"1999","unstructured":"Rhees RW, Al-Saleh HN, Kinghorn EW, Fleming DE, Lephart ED (1999) Relationship between sexual behavior and sexually dimorphic structures in the anterior hypothalamus in control and prenatally stressed male rats. Brain Res Bull 50:193\u2013199","journal-title":"Brain Res Bull"},{"key":"9784_CR45","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/sleep\/33.4.427","volume":"33","author":"CP Romanowski","year":"2010","unstructured":"Romanowski CP, Fenzl T, Flachskamm C, Wurst W, Holsboer F, Deussing JM, Kimura M (2010) Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice. Sleep 33:427\u2013436","journal-title":"Sleep"},{"key":"9784_CR46","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","volume":"404","author":"MW Schwartz","year":"2000","unstructured":"Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404:661\u2013671","journal-title":"Nature"},{"key":"9784_CR47","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1365-2826.2004.01195.x","volume":"16","author":"JV Seale","year":"2004","unstructured":"Seale JV, Wood SA, Atkinson HC, Bate E, Lightman SL, Ingram CD, Jessop DS, Harbuz MS (2004) Gonadectomy reverses the sexually diergic patterns of circadian and stress-induced hypothalamic-pituitary-adrenal axis activity in male and female rats. J Neuroendocrinol 16:516\u2013524","journal-title":"J Neuroendocrinol"},{"key":"9784_CR48","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1210\/en.2008-0723","volume":"150","author":"A Stengel","year":"2009","unstructured":"Stengel A, Goebel M, Million M, Stenzel-Poore MP, Kobelt P, Monnikes H, Tache Y, Wang L (2009) Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fasting. Endocrinology 150:153\u2013160","journal-title":"Endocrinology"},{"key":"9784_CR49","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1210\/en.130.6.3378","volume":"130","author":"MP Stenzel-Poore","year":"1992","unstructured":"Stenzel-Poore MP, Cameron VA, Vaughan J, Sawchenko PE, Vale W (1992) Development of Cushing\u2019s syndrome in corticotropin-releasing factor transgenic mice. Endocrinology 130:3378\u20133386","journal-title":"Endocrinology"},{"key":"9784_CR50","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1523\/JNEUROSCI.14-05-02579.1994","volume":"14","author":"MP Stenzel-Poore","year":"1994","unstructured":"Stenzel-Poore MP, Heinrichs SC, Rivest S, Koob GF, Vale WW (1994) Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior. J Neurosci 14:2579\u20132584","journal-title":"J Neurosci"},{"key":"9784_CR51","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejphar.2007.10.045","volume":"580","author":"EA Stone","year":"2008","unstructured":"Stone EA, Lin Y (2008) An anti-immobility effect of exogenous corticosterone in mice. Eur J Pharmacol 580:135\u2013142","journal-title":"Eur J Pharmacol"},{"key":"9784_CR52","doi-asserted-by":"crossref","first-page":"9468","DOI":"10.1073\/pnas.0403159101","volume":"101","author":"H Tezval","year":"2004","unstructured":"Tezval H, Jahn O, Todorovic C, Sasse A, Eckart K, Spiess J (2004) Cortagine, a specific agonist of corticotropin-releasing factor receptor subtype 1, is anxiogenic and antidepressive in the mouse model. Proc Natl Acad Sci USA 101:9468\u20139473","journal-title":"Proc Natl Acad Sci USA"},{"key":"9784_CR63","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.psyneuen.2008.03.013","volume":"33","author":"C Touma","year":"2008","unstructured":"Touma C, Bunck M, Glasl L, Nussbaumer M, Palme R, Stein H, Wolferst\u00e4tter M, Zeh R, Zimbelmann M, Holsboer F, Landgraf R (2008) Mice selected for high versus low stress reactivity: a new animal model for affective disorders. Psychoneuroendocrinology 33:839\u2013862","journal-title":"Psychoneuroendocrinology"},{"key":"9784_CR53","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.biopsych.2011.07.023","volume":"70","author":"C Touma","year":"2011","unstructured":"Touma C, Gassen NC, Herrmann L, Cheung-Flynn J, Bull DR, Ionescu IA, Heinzmann JM, Knapman A, Siebertz A, Depping AM, Hartmann J, Hausch F, Schmidt MV, Holsboer F, Ising M, Cox MB, Schmidt U, Rein T (2011) FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biol Psychiatry 70:928\u2013936","journal-title":"Biol Psychiatry"},{"key":"9784_CR54","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/12703","volume":"23","author":"F Tronche","year":"1999","unstructured":"Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, Orban PC, Bock R, Klein R, Schutz G (1999) Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23:99\u2013103","journal-title":"Nat Genet"},{"key":"9784_CR55","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1126\/science.6267699","volume":"213","author":"W Vale","year":"1981","unstructured":"Vale W, Spiess J, Rivier C, Rivier J (1981) Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 213:1394\u20131397","journal-title":"Science"},{"key":"9784_CR56","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.2353\/ajpath.2007.060804","volume":"170","author":"J Brandt van den","year":"2007","unstructured":"van den Brandt J, Luhder F, McPherson KG, de Graaf KL, Tischner D, Wiehr S, Herrmann T, Weissert R, Gold R, Reichardt HM (2007) Enhanced glucocorticoid receptor signaling in T cells impacts thymocyte apoptosis and adaptive immune responses. Am J Pathol 170:1041\u20131053","journal-title":"Am J Pathol"},{"key":"9784_CR57","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1046\/j.1460-9568.2002.02040.x","volume":"15","author":"MM Gaalen van","year":"2002","unstructured":"van Gaalen MM, Stenzel-Poore MP, Holsboer F, Steckler T (2002) Effects of transgenic overproduction of CRH on anxiety-like behaviour. Eur J Neurosci 15:2007\u20132015","journal-title":"Eur J Neurosci"},{"key":"9784_CR58","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pbb.2009.03.015","volume":"93","author":"E Vicentini","year":"2009","unstructured":"Vicentini E, Arban R, Angelici O, Maraia G, Perico M, Mugnaini M, Ugolini A, Large C, Domenici E, Gerrard P, Bortner D, Mansuy IM, Mangiarini L, Merlo-Pich E (2009) Transient forebrain over-expression of CRF induces plasma corticosterone and mild behavioural changes in adult conditional CRF transgenic mice. Pharmacol Biochem Behav 93:17\u201324","journal-title":"Pharmacol Biochem Behav"},{"key":"9784_CR59","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.psyneuen.2010.09.007","volume":"36","author":"KV Wagner","year":"2011","unstructured":"Wagner KV, Wang XD, Liebl C, Scharf SH, Muller MB, Schmidt MV (2011) Pituitary glucocorticoid receptor deletion reduces vulnerability to chronic stress. Psychoneuroendocrinology 36:579\u2013587","journal-title":"Psychoneuroendocrinology"},{"key":"9784_CR60","first-page":"R141","volume":"255","author":"BP Warwick","year":"1988","unstructured":"Warwick BP, Romsos DR (1988) Energy balance in adrenalectomized ob\/ob mice: effects of dietary starch and glucose. Am J Physiol 255:R141\u2013R148","journal-title":"Am J Physiol"},{"key":"9784_CR61","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1095\/biolreprod59.4.925","volume":"59","author":"Y Zhu","year":"1998","unstructured":"Zhu Y, Pintar JE (1998) Expression of opioid receptors and ligands in pregnant mouse uterus and placenta. Biol Reprod 59:925\u2013932","journal-title":"Biol Reprod"},{"key":"9784_CR62","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0165-6147(03)00177-9","volume":"24","author":"EP Zorrilla","year":"2003","unstructured":"Zorrilla EP, Tache Y, Koob GF (2003) Nibbling at CRF receptor control of feeding and gastrocolonic motility. Trends Pharmacol Sci 24:421\u2013427","journal-title":"Trends Pharmacol Sci"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-011-9784-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10571-011-9784-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-011-9784-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T06:11:49Z","timestamp":1561097509000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10571-011-9784-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,25]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["9784"],"URL":"https:\/\/doi.org\/10.1007\/s10571-011-9784-0","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,25]]}}}