{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:22:24Z","timestamp":1780086144844,"version":"3.54.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T00:00:00Z","timestamp":1326931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1007\/s10571-011-9789-8","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T12:47:50Z","timestamp":1326890870000},"page":"943-947","source":"Crossref","is-referenced-by-count":45,"title":["The Molecular Anatomy of Human Hsp60 and its Similarity with that of Bacterial Orthologs and Acetylcholine Receptor Reveal a Potential Pathogenetic Role of Anti-Chaperonin Immunity in Myasthenia Gravis"],"prefix":"10.1007","volume":"32","author":[{"given":"Antonella","family":"Marino Gammazza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Bucchieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi M. E.","family":"Grimaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arcangelo","family":"Benigno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everly","family":"Conway de Macario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto J. L.","family":"Macario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Zummo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cappello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,1,19]]},"reference":[{"key":"9789_CR1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0197-0186(99)00154-0","volume":"36","author":"HR Arias","year":"2000","unstructured":"Arias HR (2000) Localization of agonist and competitive antagonist binding sites and nicotinic acetylcholine receptors. Neurochem Int 36:595\u2013645","journal-title":"Neurochem Int"},{"key":"9789_CR2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/35077011","volume":"411","author":"K Brejc","year":"2001","unstructured":"Brejc K, Van Dijk WJ, Klaassen RV, Schuurmans M, van Der Oost J, Smit AB, Sixma TK (2001) Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature 411:269\u2013276","journal-title":"Nature"},{"key":"9789_CR3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1744-313X.2008.00819.x","volume":"36","author":"C Campanella","year":"2009","unstructured":"Campanella C, Marino Gammazza A, Mularoni L, Cappello F, Zummo G, Di Felice V (2009) A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response. Int J Immunogenet 36:73\u201378","journal-title":"Int J Immunogenet"},{"issue":"8","key":"9789_CR4","doi-asserted-by":"crossref","first-page":"e1000552","DOI":"10.1371\/journal.ppat.1000552","volume":"5","author":"F Cappello","year":"2009","unstructured":"Cappello F, Conway de Macario E, Di Felice V, Zummo G, Macario AJL (2009) Chlamydia trachomatis infection and anti-Hsp60 immunity: the two sides of the coin. PLoS Pathog 5(8):e1000552","journal-title":"PLoS Pathog"},{"key":"9789_CR5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jns.2010.02.021","volume":"292","author":"F Cappello","year":"2010","unstructured":"Cappello F, Marino Gammazza A, Zummo L, Conway de Macario E, Macario AJL (2010) Hsp60 and AChR cross-reactivity in myasthenia gravis: an update. J Neurol Sci 292:117\u2013118","journal-title":"J Neurol Sci"},{"key":"9789_CR6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0198-8859(99)00117-2","volume":"61","author":"P Deitiker","year":"2000","unstructured":"Deitiker P, Ashizawa T, Atassi MZ (2000) Antigen mimicry in autoimmune disease. Can immune responses to microbial antigens that mimic acetylcholine receptor act as initial triggers of myasthenia gravis? Hum Immunol 61:255\u2013265","journal-title":"Hum Immunol"},{"key":"9789_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-0-387-39975-1_1","volume":"594","author":"RJ Ellis","year":"2007","unstructured":"Ellis RJ (2007) Protein misassembly: macromolecular crowding and molecular chaperones. Adv Exp Med Biol 594:1\u201313","journal-title":"Adv Exp Med Biol"},{"key":"9789_CR8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/9780470754030.ch2","volume":"291","author":"J Haak","year":"2008","unstructured":"Haak J, Kregel KC (2008) 1962\u20132007: a cell stress odyssey. Novartis Found Symp 291:3\u201315","journal-title":"Novartis Found Symp"},{"key":"9789_CR9","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1007\/s00018-007-6413-7","volume":"64","author":"C Habich","year":"2007","unstructured":"Habich C, Burkart V (2007) Heat shock protein 60: regulatory role on innate immune cells. Cell Mol Life Sci 64:742\u2013751","journal-title":"Cell Mol Life Sci"},{"key":"9789_CR10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000322737","volume":"65","author":"G Helgeland","year":"2011","unstructured":"Helgeland G, Petzold A, Luckman SP, Gilhus NE, Plant GT, Romi FR (2011) Matrix metalloproteinases in myasthenia gravis. Eur Neurol 65:53\u201358","journal-title":"Eur Neurol"},{"key":"9789_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cbf.1609","volume":"28","author":"B Henderson","year":"2010","unstructured":"Henderson B (2010) Integrating the cell stress response: a new view of molecular chaperones as immunological and physiological homeostatic regulators. Cell Biochem Funct 28:1\u201314","journal-title":"Cell Biochem Funct"},{"key":"9789_CR12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jneuroim.2008.05.020","volume":"201\u2013202","author":"R Hohlfeld","year":"2008","unstructured":"Hohlfeld R, Wekerle H (2008) Reflections on the \u201cintrathymic pathogenesis\u201d of myasthenia gravis. J Neuroimmunol 201\u2013202:21\u201327","journal-title":"J Neuroimmunol"},{"key":"9789_CR13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev.cellbio.23.090506.123555","volume":"23","author":"AL Horwich","year":"2007","unstructured":"Horwich AL, Fenton WA, Chapman E, Farr GW (2007) Two families of chaperonin: physiology and mechanism. Annu Rev Cell Dev Biol 23:115\u2013145","journal-title":"Annu Rev Cell Dev Biol"},{"key":"9789_CR14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1196\/annals.1405.019","volume":"1132","author":"R Le Panse","year":"2008","unstructured":"Le Panse R, Cizeron-Clairac G, Cuvelier M, Truffault F, Bismuth J, Nancy P, De Rosbo NK, Berrih-Aknin S (2008) Regulatory and pathogenic mechanisms in human autoimmune myasthenia gravis. Ann N Y Acad Sci 1132:135\u2013142","journal-title":"Ann N Y Acad Sci"},{"key":"9789_CR15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1196\/annals.1405.007","volume":"1132","author":"J Lindstrom","year":"2008","unstructured":"Lindstrom J, Luo J, Kuryatov A (2008) Myasthenia gravis and the tops and bottoms of AChRs: antigenic structure of the MIR and specific immunosuppression of EAMG using AChR cytoplasmic domains. Ann N Y Acad Sci 1132:29\u201341","journal-title":"Ann N Y Acad Sci"},{"key":"9789_CR16","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1574-6976.2009.00178.x","volume":"33","author":"PA Lund","year":"2009","unstructured":"Lund PA (2009) Multiple chaperonins in bacteria\u2014why so many? FEMS Microbiol Rev 33:785\u2013800","journal-title":"FEMS Microbiol Rev"},{"key":"9789_CR17","doi-asserted-by":"crossref","first-page":"13898","DOI":"10.1523\/JNEUROSCI.2833-09.2009","volume":"29","author":"J Luo","year":"2009","unstructured":"Luo J, Taylor P, Losen M, de Baets MH, Shelton GD, Lindstrom J (2009) Main immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies, nicotinic acetylcholine receptor conformation maturation, and agonist sensitivity. J Neurosci 29:13898\u201313908","journal-title":"J Neurosci"},{"key":"9789_CR18","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1128\/MMBR.63.4.923-967.1999","volume":"63","author":"AJL Macario","year":"1999","unstructured":"Macario AJL, Lange M, Ahring BK, Conway de Macario E (1999) Stress genes and proteins in the archaea. Microbiol Mol Biol Rev 63:923\u2013967","journal-title":"Microbiol Mol Biol Rev"},{"key":"9789_CR19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1749-6632.2010.05187.x","volume":"1197","author":"AJL Macario","year":"2010","unstructured":"Macario AJL, Cappello F, Zummo G, Conway de Macario E (2010) Chaperonopathies of senescence and the scrambling of interactions between the chaperoning and the immune systems. Ann N Y Acad Sci 1197:85\u201393","journal-title":"Ann N Y Acad Sci"},{"key":"9789_CR20","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1002\/(SICI)1521-4141(199808)28:08<2487::AID-IMMU2487>3.0.CO;2-Y","volume":"28","author":"L Moiola","year":"1998","unstructured":"Moiola L, Galbiati F, Martino G, Amadio S, Brambilla E, Comi G, Vincent A, Grimaldi LM, Adorini L (1998) IL-12 is involved in the induction of experimental autoimmune myasthenia gravis, an antibody-mediated disease. Eur J Immunol 28:2487\u20132497","journal-title":"Eur J Immunol"},{"key":"9789_CR21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.it.2010.11.001","volume":"32","author":"FJ Quintana","year":"2011","unstructured":"Quintana FJ, Cohen IR (2011) The HSP60 immune system network. Trends Immunol 32:89\u201395","journal-title":"Trends Immunol"},{"key":"9789_CR22","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1099\/jmm.0.020420-0","volume":"59","author":"M Sakamoto","year":"2010","unstructured":"Sakamoto M, Ohkuma M (2010) Usefulness of the hsp60 gene for the identification and classification of Gram-negative anaerobic rods. J Med Microbiol 59:1293\u20131302","journal-title":"J Med Microbiol"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-011-9789-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10571-011-9789-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-011-9789-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:13:51Z","timestamp":1593562431000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10571-011-9789-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,19]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["9789"],"URL":"https:\/\/doi.org\/10.1007\/s10571-011-9789-8","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,19]]}}}