{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:08:13Z","timestamp":1791065293114,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,8,7]],"date-time":"2012-08-07T00:00:00Z","timestamp":1344297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s10571-012-9871-x","type":"journal-article","created":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T10:44:06Z","timestamp":1344249846000},"page":"59-67","source":"Crossref","is-referenced-by-count":48,"title":["An Evaluation of the Antinociceptive Effects of Ph\u03b11\u03b2, a Neurotoxin from the Spider Phoneutria nigriventer, and \u03c9-Conotoxin MVIIA, a Cone Snail Conus magus Toxin, in Rat Model of Inflammatory and Neuropathic Pain"],"prefix":"10.1007","volume":"33","author":[{"given":"Alessandra Hubner","family":"de Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"C\u00e9lio J.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia Karine","family":"Rigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Marchesan","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Santiago","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danuza Montijo","family":"Diniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Helena","family":"Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Nascimento","family":"Cordeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Aur\u00e9lio Romano","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus Vinicius","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,7]]},"reference":[{"key":"9871_CR1","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.tips.2004.07.004","volume":"25","author":"C Altier","year":"2004","unstructured":"Altier C, Zamponi GW (2004) Targeting Ca2+ channels to treat pain: T-type versus N-type. Trends Pharmacol Sci 25:465\u2013470","journal-title":"Trends Pharmacol Sci"},{"key":"9871_CR2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","volume":"33","author":"GJ Bennett","year":"1988","unstructured":"Bennett GJ, Xie YK (1988) A peripheral mononeuropathy in rat produces disorders of pain sensation like those seen in man. Pain 33:87\u2013107","journal-title":"Pain"},{"key":"9871_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/35036035","volume":"1","author":"MJ Berridge","year":"2000","unstructured":"Berridge MJ, Lipp P, Bootman MD (2000) The versatility and universality of calcium signaling. Nat Rev Mol Cell Biol 1:11\u201321","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9871_CR4","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0022-3565(25)21283-6","volume":"279","author":"SS Bowersox","year":"1996","unstructured":"Bowersox SS, Gadbois T, Singh T, Pettus M, Wang YX, Luther RR (1996) Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain. J Pharmacol Exp Ther 279:1243\u20131249","journal-title":"J Pharmacol Exp Ther"},{"key":"9871_CR5","doi-asserted-by":"publisher","first-page":"e7383","DOI":"10.1371\/journal.pone.0007383","volume":"4","author":"O Caspani","year":"2009","unstructured":"Caspani O, Zurborg S, Labuz D, Heppenstall PA (2009) The contribution of TRPM8 and TRPA1 channels to cold allodynia and neurophatic pain. PLoS ONE 4:e7383","journal-title":"PLoS ONE"},{"key":"9871_CR6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","volume":"53","author":"SR Chaplan","year":"1994","unstructured":"Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL (1994) Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53:55\u201363","journal-title":"J Neurosci Methods"},{"key":"9871_CR7","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1007\/s00221-002-1217-3","volume":"147","author":"D Cizkova","year":"2002","unstructured":"Cizkova D et al (2002) Localization of N-type Ca2+ channels in the rat spinal cord following chronic constrictive nerve injury. Exp Brain Res 147:456\u2013463","journal-title":"Exp Brain Res"},{"key":"9871_CR8","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0041-0101(93)90354-L","volume":"31","author":"N Cordeiro Mdo","year":"1993","unstructured":"Cordeiro Mdo N et al (1993) Purification and amino acid sequences of six Tx3 type neurotoxins from the venom of the Brazilian \u2018armed\u2019 spider Phoneutria nigriventer. Toxicon 31:35\u201342","journal-title":"Toxicon"},{"key":"9871_CR9","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","volume":"20","author":"WJ Dixon","year":"1980","unstructured":"Dixon WJ (1980) Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 20:441\u2013462","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"9871_CR10","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1006\/bbrc.2001.5272","volume":"285","author":"SY Eun","year":"2001","unstructured":"Eun SY, Jung SJ, Park YK, Kwak J, Kim SJ, Kim J (2001) Effects of capsaicin on Ca2+ release from the intracellular Ca2+ stores in the dorsal root ganglion cells of adult rats. Biochem Biophys Res Commun 285:1114\u20131120","journal-title":"Biochem Biophys Res Commun"},{"key":"9871_CR12","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1097\/00001756-200405190-00021","volume":"15","author":"DA Gomes","year":"2004","unstructured":"Gomes DA et al (2004) Effect of halothane on the release of [Ca2+]i in dorsal root ganglion neurons. NeuroReport 15:1187\u20131190","journal-title":"NeuroReport"},{"key":"9871_CR13","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1517\/13543776.15.12.1751","volume":"15","author":"VK Gribkoff","year":"2005","unstructured":"Gribkoff VK, Winquist RJ (2005) Modulators of peripheral voltage-gated sodium channels for the treatment of neuropathic pain. Expert Opin Ther Patents 15:1751\u20131762","journal-title":"Expert Opin Ther Patents"},{"key":"9871_CR14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/00115550-200207000-00009","volume":"27","author":"Q Hogan","year":"2002","unstructured":"Hogan Q (2002) Animal pain models. Reg Anesth Pain Med 27:385\u2013401","journal-title":"Reg Anesth Pain Med"},{"key":"9871_CR15","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0304-3959(99)00313-9","volume":"86","author":"QH Hogan","year":"2000","unstructured":"Hogan QH et al (2000) Painful neuropathy decreases membrane calcium current in mammalian primary afferent neurons. Pain 86:43\u201353","journal-title":"Pain"},{"key":"9871_CR16","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/35093019","volume":"413","author":"D Julius","year":"2001","unstructured":"Julius D, Basbaum AI (2001) Molecular mechanisms of nociception. Nature 413:203\u2013210","journal-title":"Nature"},{"key":"9871_CR17","first-page":"ES39","volume":"107","author":"E Katherine","year":"2007","unstructured":"Katherine E, Galluzzi DO (2007) Managing neuropathic pain. J Am Osteopath Assoc 107:ES39\u2013ES48","journal-title":"J Am Osteopath Assoc"},{"key":"9871_CR18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1016-8478(23)25242-5","volume":"20","author":"Y Lee","year":"2005","unstructured":"Lee Y, Lee CH, Oh U (2005) Painful channels in sensory neurons. Mol Cells 20:315\u2013324","journal-title":"Mol Cells"},{"key":"9871_CR19","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.neuroscience.2008.02.006","volume":"153","author":"SG Lu","year":"2008","unstructured":"Lu SG, Gold MS (2008) Inflammation-induced increase in evoked calcium transients in subpopulations of rat dorsal root ganglion neurons. Neuroscience 153:279\u2013288","journal-title":"Neuroscience"},{"key":"9871_CR20","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.pain.2010.08.030","volume":"151","author":"SG Lu","year":"2010","unstructured":"Lu SG, Zhang XL, Luo ZD, Gold MS (2010) Persistent inflammation alters the density and distribution of voltage-activated calcium channels in subpopulations of rat cutaneous DRG neurons. Pain 151:633\u2013643","journal-title":"Pain"},{"key":"9871_CR21","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/0304-3959(94)00094-U","volume":"60","author":"AB Malmberg","year":"1995","unstructured":"Malmberg AB, Yaksh TL (1995) Effect of continuous intrathecal infusion of \u03c9-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats. Pain 60:83\u201390","journal-title":"Pain"},{"key":"9871_CR22","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1097\/00000542-200607000-00026","volume":"105","author":"JB McCallum","year":"2006","unstructured":"McCallum JB, Kwok WM, Sapunar D, Fuchs A, Hogan QH (2006) Painful peripheral nerve injury decreases calcium current in axotomized sensory neurons. Anesthesiology 105:160\u2013168","journal-title":"Anesthesiology"},{"key":"9871_CR23","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/j.1399-6576.1997.tb04634.x","volume":"41","author":"HJ McQuay","year":"1997","unstructured":"McQuay HJ (1997) Opioid use in chronic pain. Acta Anaesthesiol Scand 41:175\u2013183","journal-title":"Acta Anaesthesiol Scand"},{"key":"9871_CR24","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/1056-8719(94)90087-6","volume":"32","author":"C Mestre","year":"1994","unstructured":"Mestre C, Pelissier T, Fialip J, Wilcox G, Eschalier A (1994) A method to perform direct transcutaneous intrathecal injection in rats. J Pharmacol Toxicol Methods 32:197\u2013200","journal-title":"J Pharmacol Toxicol Methods"},{"key":"9871_CR25","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1146\/annurev.pa.35.040195.003423","volume":"35","author":"GP Miljanich","year":"1995","unstructured":"Miljanich GP, Ramachandran J (1995) Antagonists of neuronal calcium channel: structure, function, and therapeutic implications. Annu Rev Pharmacol Toxicol 35:707\u2013734","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"9871_CR26","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1124\/jpet.103.050781","volume":"306","author":"Y Nagakura","year":"2003","unstructured":"Nagakura Y et al (2003) Allodynia and hyperalgesia in adjuvant-induced arthritic rats: time course of progression and efficacy of analgesics. J Pharmacol Exp Ther 306:490\u2013497","journal-title":"J Pharmacol Exp Ther"},{"key":"9871_CR27","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0304-3959(99)00254-7","volume":"85","author":"RD Penn","year":"2000","unstructured":"Penn RD, Paice JA (2000) Adverse effects associated with the intrathecal administration of ziconotide. Pain 85:291\u2013296","journal-title":"Pain"},{"key":"9871_CR28","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/j.1533-2500.2008.00204.x","volume":"8","author":"J Pergolizzi","year":"2008","unstructured":"Pergolizzi J et al (2008) Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone). Pain Pract 8:287\u2013313","journal-title":"Pain Pract"},{"key":"9871_CR29","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.berh.2011.02.005","volume":"25","author":"K Phillips","year":"2011","unstructured":"Phillips K, Clauw DJ (2011) Central pain mechanisms in chronic pain states\u2014maybe it is all in their head. Best Pract Res Clin Rheumatol 25:141\u2013154","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"9871_CR30","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1093\/emboj\/20.10.2349","volume":"20","author":"H Saegusa","year":"2001","unstructured":"Saegusa H et al (2001) Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel. EMBO J 20:2349\u20132356","journal-title":"EMBO J"},{"key":"9871_CR31","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1016\/S0140-6736(10)60354-6","volume":"375","author":"A Schmidtko","year":"2010","unstructured":"Schmidtko A, L\u00f6tsch J, Freynhagen R, Geisslinger G (2010) Ziconotide for treatment of severe chronic pain. Lancet 375:1569\u20131577","journal-title":"Lancet"},{"key":"9871_CR32","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0014-2999(02)02247-1","volume":"451","author":"DA Scott","year":"2002","unstructured":"Scott DA, Wright CE, Angus JA (2002) Actions of intrathecal \u03c9-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat. Eur J Pharmacol 451:279\u2013286","journal-title":"Eur J Pharmacol"},{"key":"9871_CR33","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1602\/neurorx.2.4.662","volume":"2","author":"TP Snutch","year":"2005","unstructured":"Snutch TP (2005) Targeting chronic and neuropathic pain: the N-type calcium channel comes of age. NeuroRx 2:662\u2013670","journal-title":"NeuroRx"},{"key":"9871_CR34","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.pain.2008.07.014","volume":"140","author":"AH Souza","year":"2008","unstructured":"Souza AH et al (2008) Analgesic effect in rodents of native and recombinant Ph alpha 1beta toxin, a high-voltage-activated calcium channel blocker isolated from armed spider venom. Pain 140:115\u2013126","journal-title":"Pain"},{"key":"9871_CR35","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.toxicon.2011.09.008","volume":"58","author":"AH Souza","year":"2011","unstructured":"Souza AH et al (2011) Antiallodynic effect and side effects of Ph\u03b11\u03b2 a neurotoxin from the spider Phoneutria nigriventer: comparison with \u03c9-conotoxin MVIIA and morphine. Toxicon 58:626\u2013633","journal-title":"Toxicon"},{"key":"9871_CR36","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.ejpain.2006.03.006","volume":"11","author":"PC Staton","year":"2007","unstructured":"Staton PC, Wilson AW, Bountra C, Chessell IP, Day NC (2007) Changes in dorsal root ganglion CGRP expression in a chronic inflammatory model of the rat knee joint: differential modulation by rofecoxib and paracetamol. Eur J Pain 11:283\u2013289","journal-title":"Eur J Pain"},{"key":"9871_CR37","doi-asserted-by":"crossref","first-page":"665","DOI":"10.33588\/rn.4511.2007266","volume":"45","author":"JC Val\u00eda-Vera","year":"2007","unstructured":"Val\u00eda-Vera JC, Villanueva VL, Asensio-Samper JM, L\u00f3pez-Alarc\u00f3n MD, de Andr\u00e9s JA (2007) Ziconotide: an innovative alternative for intense chronic neuropathic pain. Rev Neurol 45:665\u2013669","journal-title":"Rev Neurol"},{"key":"9871_CR38","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0304-3959(99)00241-9","volume":"85","author":"H Vanegas","year":"2000","unstructured":"Vanegas H, Schaible H (2000) Effects of antagonists to high-threshold calcium channels upon spinal mechanisms of pain, hyperalgesia and allodynia. Pain 85:9\u201318","journal-title":"Pain"},{"key":"9871_CR39","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1124\/jpet.105.087023","volume":"314","author":"LB Vieira","year":"2005","unstructured":"Vieira LB et al (2005) Inhibition of high voltage-activated calcium channels by spider toxin PnT3\u20136. J Pharmacol Exp Ther 314:1370\u20131377","journal-title":"J Pharmacol Exp Ther"},{"key":"9871_CR40","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1586\/14737175.6.10.1423","volume":"6","author":"MS Wallace","year":"2006","unstructured":"Wallace MS (2006) Ziconotide: a new nonopioid intrathecal analgesic for the treatment of pain. Expert Rev Neurother 6:1423\u20131428","journal-title":"Expert Rev Neurother"},{"key":"9871_CR41","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.ejpain.2005.08.003","volume":"10","author":"AW Wilson","year":"2006","unstructured":"Wilson AW et al (2006) An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models. Eur J Pain 10:537\u2013549","journal-title":"Eur J Pain"},{"key":"9871_CR42","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.bcp.2005.04.035","volume":"70","author":"RJ Winquist","year":"2005","unstructured":"Winquist RJ, Pan JQ, Gribkoff VK (2005) Use-dependent blockade of Cav2.2 voltage-gated calcium channels for neuropathic pain. Biochem Pharmacol 70:489\u2013499","journal-title":"Biochem Pharmacol"},{"key":"9871_CR43","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/1744-8069-4-61","volume":"4","author":"L Yu","year":"2008","unstructured":"Yu L et al (2008) The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund\u2019s adjuvant. Mol Pain 4:61","journal-title":"Mol Pain"},{"key":"9871_CR44","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","volume":"16","author":"M Zimmermann","year":"1983","unstructured":"Zimmermann M (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109\u2013110","journal-title":"Pain"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-012-9871-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10571-012-9871-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-012-9871-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-012-9871-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T16:07:13Z","timestamp":1743955633000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10571-012-9871-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,7]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["9871"],"URL":"https:\/\/doi.org\/10.1007\/s10571-012-9871-x","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,7]]}}}