{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T04:51:39Z","timestamp":1771563099382,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1007\/s10571-013-9919-6","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T11:09:03Z","timestamp":1362568143000},"page":"537-542","source":"Crossref","is-referenced-by-count":32,"title":["Methadone-Induced Hypoglycemia"],"prefix":"10.1007","volume":"33","author":[{"given":"Andrew J.","family":"Faskowitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir N.","family":"Kramskiy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavril W.","family":"Pasternak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"9919_CR1","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1210\/jc.85.6.2215","volume":"85","author":"R Abs","year":"2000","unstructured":"Abs R, Verhelst J, Maeyaert J, Van Buyten JP, Opsomer F, Adriaensen H, Verlooy J, Van HT, Smet M, Van AK (2000) Endocrine consequences of long-term intrathecal administration of opioids. J Clin Endocrinol Metab 85:2215\u20132222","journal-title":"J Clin Endocrinol Metab"},{"key":"9919_CR2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.taap.2008.06.020","volume":"232","author":"K Amirshahrokhi","year":"2008","unstructured":"Amirshahrokhi K, Dehpour AR, Hadjati J, Sotoudeh M, Ghazi-Khansari M (2008) Methadone ameliorates multiple-low-dose streptozotocin-induced type 1 diabetes in mice. Toxicol Appl Pharmacol 232:119\u2013124","journal-title":"Toxicol Appl Pharmacol"},{"key":"9919_CR3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0024-3205(75)90101-0","volume":"17","author":"A Baron","year":"1975","unstructured":"Baron A, Shuster L, Elefterhiou BE, Bailey DW (1975) Opiate receptors in mice: genetic differences. Life Sci 17:633\u2013640","journal-title":"Life Sci"},{"key":"9919_CR4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1124\/jpet.102.035881","volume":"303","author":"EA Bolan","year":"2002","unstructured":"Bolan EA, Tallarida RJ, Pasternak GW (2002) Synergy between mu opioid ligands: evidence for functional interactions among mu opioid receptor subtypes. J Pharmacol Exp Ther 303:557\u2013562","journal-title":"J Pharmacol Exp Ther"},{"key":"9919_CR5","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1055\/s-2007-1011844","volume":"19","author":"A Ceriello","year":"1987","unstructured":"Ceriello A, Giugliano D, Passariello N, Quatraro A, Dello RP, Torella R, D\u2019Onofrio F (1987) Impaired glucose metabolism in heroin and methadone users. Horm Metab Res 19:430\u2013433","journal-title":"Horm Metab Res"},{"key":"9919_CR6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2337\/diacare.11.5.443","volume":"11","author":"A Ceriello","year":"1988","unstructured":"Ceriello A, Quatraro A, Giugliano D (1988) Opiate addict as diabetic patient? Diabetes Care 11:443","journal-title":"Diabetes Care"},{"key":"9919_CR7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0014-2999(98)00366-5","volume":"351","author":"A Chang","year":"1998","unstructured":"Chang A, Emmel DW, Rossi GC, Pasternak GW (1998) Methadone analgesia in morphine-insensitive CXBK mice. Eur J Pharmacol 351:189\u2013191","journal-title":"Eur J Pharmacol"},{"key":"9919_CR8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0014-2999(86)90394-8","volume":"121","author":"J Chariot","year":"1986","unstructured":"Chariot J, Appia F, Vaille C, Roze C (1986) Etorphine inhibition of pancreatic exocrine secretion in rats: comparison with methadone. Eur J Pharmacol 121:73\u201381","journal-title":"Eur J Pharmacol"},{"key":"9919_CR9","first-page":"2551","volume":"39","author":"TJ Cicero","year":"1980","unstructured":"Cicero TJ (1980) Effects of exogenous and endogenous opiates on the hypothalamic\u2013pituitary\u2013gonadal axis in the male. Fed Proc 39:2551\u20132554","journal-title":"Fed Proc"},{"key":"9919_CR10","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.jpainsymman.2010.06.021","volume":"41","author":"R Dev","year":"2011","unstructured":"Dev R, Hui D, Dalal S, Nooruddin ZI, Yennurajalingam S, Del FE, Bruera E (2011) Association between serum cortisol and testosterone levels, opioid therapy, and symptom distress in patients with advanced cancer. J Pain Symptom Manage 41:788\u2013795","journal-title":"J Pain Symptom Manage"},{"key":"9919_CR11","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1124\/jpet.112.201616","volume":"344","author":"SM Dewire","year":"2013","unstructured":"Dewire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, Chen XT, Pitis PM, Gotchev D, Yuan C, Koblish M, Lark MW, Violin JD (2013) A G protein-biased ligand at the mu-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. J Pharmacol Exp Ther 344:708\u2013717","journal-title":"J Pharmacol Exp Ther"},{"key":"9919_CR12","first-page":"195","volume":"51","author":"ES Daly el","year":"1996","unstructured":"el Daly ES (1996) Effect of intrathecal morphine on blood glucose, glucagon and tissue glycogen in rat: comparison with the effect of xanthan gum on blood glucose. J Pharm Belg 51:195\u2013199","journal-title":"J Pharm Belg"},{"key":"9919_CR13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.5055\/jom.2011.0057","volume":"7","author":"JA Elliott","year":"2011","unstructured":"Elliott JA, Horton E, Fibuch EE (2011a) The endocrine effects of long-term oral opioid therapy: a case report and review of the literature. J Opioid Manag 7:145\u2013154","journal-title":"J Opioid Manag"},{"key":"9919_CR14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.5055\/jom.2011.0057","volume":"7","author":"JA Elliott","year":"2011","unstructured":"Elliott JA, Horton E, Fibuch EE (2011b) The endocrine effects of long-term oral opioid therapy: a case report and review of the literature. J Opioid Manag 7:145\u2013154","journal-title":"J Opioid Manag"},{"key":"9919_CR15","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1086\/429824","volume":"40","author":"AA Howard","year":"2005","unstructured":"Howard AA, Floris-Moore M, Arnsten JH, Santoro N, Fleischer N, Lo Y, Schoenbaum EE (2005) Disorders of glucose metabolism among HIV-infected women. Clin Infect Dis 40:1492\u20131499","journal-title":"Clin Infect Dis"},{"key":"9919_CR16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1146\/annurev.ph.48.030186.002523","volume":"48","author":"TA Howlett","year":"1986","unstructured":"Howlett TA, Rees LH (1986) Endogenous opioid peptides and hypothalamo-pituitary function. Annu Rev Physiol 48:527\u2013536","journal-title":"Annu Rev Physiol"},{"key":"9919_CR17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1677\/JOE-06-0145","volume":"192","author":"SN Lee","year":"2007","unstructured":"Lee SN, Peng B, Desjardins R, Pintar JE, Day R, Lindberg I (2007) Strain-specific steroidal control of pituitary function. J Endocrinol 192:515\u2013525","journal-title":"J Endocrinol"},{"key":"9919_CR18","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1467-2995.2005.00239.x","volume":"33","author":"EN Leibetseder","year":"2006","unstructured":"Leibetseder EN, Mosing M, Jones RS (2006) A comparison of extradural and intravenous methadone on intraoperative isoflurane and postoperative analgesia requirements in dogs. Vet Anaesth Analg 33:128\u2013136","journal-title":"Vet Anaesth Analg"},{"key":"9919_CR19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0022-3565(25)22319-9","volume":"245","author":"F Lux","year":"1988","unstructured":"Lux F, Brase DA, Dewey WL (1988) Differential effects of subcutaneous and intrathecal morphine administration on blood glucose in mice: comparison with intracerebroventricular administration. J Pharmacol Exp Ther 245:187\u2013194","journal-title":"J Pharmacol Exp Ther"},{"key":"9919_CR20","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0022-3565(25)23483-8","volume":"249","author":"F Lux","year":"1989","unstructured":"Lux F, Han YH, Brase DA, Dewey WL (1989) Studies on the mechanism of hypoglycemia induced by intrathecal morphine: dissociation from behavioral effects, effects of tolerance and depletion of liver glycogen. J Pharmacol Exp Ther 249:688\u2013693","journal-title":"J Pharmacol Exp Ther"},{"issue":"Supplement 2","key":"9919_CR21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jpain.2008.01.165","volume":"9","author":"S Maingi","year":"2008","unstructured":"Maingi S, Moryl N, Faskowitz A (2008) Symptomatic hypoglycemia due to escalating doses of intravenous methadone. J Pain 9(Supplement 2):37","journal-title":"J Pain"},{"issue":"618","key":"9919_CR22","first-page":"8","volume":"25","author":"S Majumdar","year":"2011","unstructured":"Majumdar S, Grinnell S, Burgman M, polikar L, Le Rouzic V, Asonoff M, Pan YX, Pasternak GW (2011) Targeting truncated G-protein coupled opioid receptors for treatment of pain without side-effects. FASEB J 25(618):8","journal-title":"FASEB J"},{"key":"9919_CR23","doi-asserted-by":"crossref","first-page":"14084","DOI":"10.1073\/pnas.241296098","volume":"98","author":"Y-X Pan","year":"2001","unstructured":"Pan Y-X, Xu J, Mahurter L, Bolan EA, Xu MM, Pasternak GW (2001) Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene. Proc Natl Acad Sci USA 98:14084\u201314089","journal-title":"Proc Natl Acad Sci USA"},{"key":"9919_CR24","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1073\/pnas.0811586106","volume":"106","author":"YX Pan","year":"2009","unstructured":"Pan YX, Xu J, Xu M, Rossi GC, Matulonis JE, Pasternak GW (2009) Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions. Proc Natl Acad Sci USA 106:4917\u20134922","journal-title":"Proc Natl Acad Sci USA"},{"key":"9919_CR25","doi-asserted-by":"crossref","unstructured":"Pasternak GW, Pan Y-X (2013) Mu opioids and their receptors: evolution of a concept. Pharmacol Rev (in press)","DOI":"10.1124\/pr.112.007138"},{"key":"9919_CR26","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0022-3565(25)38099-7","volume":"2265","author":"CG Pick","year":"1993","unstructured":"Pick CG, Nejat R, Pasternak GW (1993) Independent expression of two pharmacologically distinct supraspinal mu analgesic systems in genetically different mouse strains. J Pharmacol Exp Ther 2265:166\u2013171","journal-title":"J Pharmacol Exp Ther"},{"key":"9919_CR27","first-page":"1291","volume":"78","author":"G Rastelli","year":"1987","unstructured":"Rastelli G, Gerra G, Mineo F, Ceresini G, Baroni MC, Caccavari R, Delsignore R, Vescovi PP (1987) Homeostasis of blood glucose and abuse of exogenous opiates: evaluation of fructosamine and glycosylated hemoglobin. Minerva Med 78:1291\u20131296","journal-title":"Minerva Med"},{"key":"9919_CR28","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0014-2999(81)90059-5","volume":"74","author":"MEA Reith","year":"1981","unstructured":"Reith MEA, Sershen H, Vadasz C, Lajtha A (1981) Strain differences in opiate receptors in mouse brain. Eur J Pharmacol 74:377\u2013380","journal-title":"Eur J Pharmacol"},{"key":"9919_CR29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0306-3623(96)00165-6","volume":"28","author":"D Sadava","year":"1997","unstructured":"Sadava D, Alonso D, Hong H, Pettit-Barrett DP (1997) Effect of methadone addiction on glucose metabolism in rats. Gen Pharmacol 28:27\u201329","journal-title":"Gen Pharmacol"},{"key":"9919_CR30","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/0024-3205(82)90112-6","volume":"31","author":"K Spiegel","year":"1982","unstructured":"Spiegel K, Kourides IA, Pasternak GW (1982) Different receptors mediate morphine-induced prolactin and growth hormone release. Life Sci 31:2177\u20132180","journal-title":"Life Sci"},{"key":"9919_CR31","first-page":"227","volume":"35","author":"H Tenhola","year":"2012","unstructured":"Tenhola H, Sinclair D, Alho H, Lahti T (2012) Effect of opioid antagonists on sex hormone secretion. J Endocrinol Invest 35:227\u2013230","journal-title":"J Endocrinol Invest"},{"key":"9919_CR32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2337\/diabetes.35.1.52","volume":"35","author":"KI Timmers","year":"1986","unstructured":"Timmers KI, Voyles NR, King C, Wells M, Fairtile R, Recant L (1986) Opioid peptides in rat islets of Langerhans. Immunoreactive met- and leu-enkephalins and BAM-22P. Diabetes 35:52\u201357","journal-title":"Diabetes"},{"key":"9919_CR33","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.annemergmed.2006.02.023","volume":"48","author":"S Tiras","year":"2006","unstructured":"Tiras S, Haas V, Chevret L, Decobert M, Buisine A, Devictor D, Durand P, Tissieres P (2006) Nonketotic hyperglycemic coma in toddlers after unintentional methadone ingestion. Ann Emerg Med 48:448\u2013451","journal-title":"Ann Emerg Med"},{"key":"9919_CR34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1210\/er.2009-0009","volume":"31","author":"C Vuong","year":"2010","unstructured":"Vuong C, Van Uum SH, O\u2019Dell LE, Lutfy K, Friedman TC (2010) The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev 31:98\u2013132","journal-title":"Endocr Rev"},{"key":"9919_CR35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0022-3565(25)07748-1","volume":"102","author":"DJ Watts","year":"1951","unstructured":"Watts DJ (1951) The effect of methadone isomers, morphine, and pentobarbital on the blood glucose of dogs. J Pharmacol Exp Ther 102:269\u2013271","journal-title":"J Pharmacol Exp Ther"},{"key":"9919_CR36","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1212\/WNL.17.7.703","volume":"17","author":"IC Wiederholt","year":"1967","unstructured":"Wiederholt IC, Genco M, Foley JM (1967) Recurrent episodes of hypoglycemia induced by propoxyphene. Neurology 17:703\u2013706","journal-title":"Neurology"},{"key":"9919_CR37","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/S0024-3205(97)00919-3","volume":"61","author":"S Willenbring","year":"1997","unstructured":"Willenbring S, Stevens CW (1997) Spinal \u03bc, \u03b4 and k opioids alter chemical, mechanical and thermal sensitivities in amphibians. Life Sci 61:2167\u20132176","journal-title":"Life Sci"},{"key":"9919_CR38","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.brainres.2005.01.070","volume":"1040","author":"S Zelcer","year":"2005","unstructured":"Zelcer S, Kolesnikov YA, Kovalyshyn I, Pasternak DA, Pasternak GW (2005) Selective potentiation of opioid analgesia by nonsteroidal anti-inflammatory drugs. Brain Res 1040:151\u2013156","journal-title":"Brain Res"},{"key":"9919_CR39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1677\/joe.1.06960","volume":"191","author":"Y Zhou","year":"2006","unstructured":"Zhou Y, Bendor J, Hofmann L, Randesi M, Ho A, Kreek MJ (2006) Mu opioid receptor and orexin\/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal. J Endocrinol 191:137\u2013145","journal-title":"J Endocrinol"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-013-9919-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10571-013-9919-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-013-9919-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T23:20:15Z","timestamp":1745968815000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10571-013-9919-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,7]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["9919"],"URL":"https:\/\/doi.org\/10.1007\/s10571-013-9919-6","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,7]]}}}