{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:38:26Z","timestamp":1791650306594,"version":"4.3.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T00:00:00Z","timestamp":1366934400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1007\/s10571-013-9939-2","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T14:36:11Z","timestamp":1367332571000},"page":"715-722","source":"Crossref","is-referenced-by-count":46,"title":["Xanthotoxol Exerts Neuroprotective Effects Via Suppression of the Inflammatory Response in a Rat Model of Focal Cerebral Ischemia"],"prefix":"10.1007","volume":"33","author":[{"given":"Wei","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuantong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,26]]},"reference":[{"issue":"1","key":"9939_CR1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1742-4658.2008.06766.x","volume":"276","author":"D Amantea","year":"2009","unstructured":"Amantea D, Nappi G, Bernardi G, Bagetta G, Corasaniti MT (2009) Post-ischemic brain damage: pathophysiology and role of inflammatory mediators. FEBS J 276(1):13\u201326","journal-title":"FEBS J"},{"issue":"4","key":"9939_CR2","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/j.1471-4159.2006.04280.x","volume":"100","author":"E Candelario-Jalil","year":"2007","unstructured":"Candelario-Jalil E, Gonz\u00e1lez-Falc\u00f3n A, Garc\u00eda-Cabrera M, Le\u00f3n OS, Fiebich BL (2007) Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats. J Neurochem 100(4):1108\u20131120","journal-title":"J Neurochem"},{"issue":"1\u20132","key":"9939_CR3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejphar.2005.11.049","volume":"530","author":"M Collino","year":"2006","unstructured":"Collino M, Aragno M, Mastrocola R, Gallicchio M, Rosa AC, Dianzani C, Danni O, Thiemermann C, Fantozzi R (2006) Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia\/reperfusion. Eur J Pharmacol 530(1\u20132):70\u201380","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"9939_CR4","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s11064-010-0366-1","volume":"36","author":"V Danielisova","year":"2011","unstructured":"Danielisova V, Burda J, Nemethova M, Gottlieb M (2011) Aminoguanidine administration ameliorates hippocampal damage after middle cerebral artery occlusion in rat. Neurochem Res 36(3):476\u2013486","journal-title":"Neurochem Res"},{"issue":"1","key":"9939_CR5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1750-3639.2000.tb00247.x","volume":"10","author":"G Zoppo del","year":"2000","unstructured":"del Zoppo G, Ginis I, Hallenbeck JM, Iadecola C, Wang X, Feuerstein GZ (2000) Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol 10(1):95\u2013112","journal-title":"Brain Pathol"},{"issue":"5","key":"9939_CR6","first-page":"668","volume":"25","author":"W He","year":"2009","unstructured":"He W, Chen WW, Ye HY, Zhou YM, Huang XH (2009) Inhibitory effects of xanthotoxol on neutrophil infiltration and brain edema induced by focal cerebral ischemia-reperfusion injury in rats. Chin Pharmacol Bull 25(5):668\u2013672","journal-title":"Chin Pharmacol Bull"},{"issue":"3","key":"9939_CR7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.surneu.2005.12.028","volume":"66","author":"J Huang","year":"2006","unstructured":"Huang J, Upadhyay UM, Tamargo RJ (2006) Inflammation in stroke and focal cerebral ischemia. Surg Neurol 66(3):232\u2013245","journal-title":"Surg Neurol"},{"issue":"5","key":"9939_CR8","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1189\/jlb.1109766","volume":"87","author":"R Jin","year":"2010","unstructured":"Jin R, Yang G, Li G (2010) Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol 87(5):779\u2013789","journal-title":"J Leukoc Biol"},{"issue":"4","key":"9939_CR9","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/jnr.20087","volume":"76","author":"M Khan","year":"2004","unstructured":"Khan M, Sekhon B, Jatana M, Giri S, Gilg AG, Sekhon C, Singh I, Singh AK (2004) Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke. J Neurosci Res 76(4):519\u2013527","journal-title":"J Neurosci Res"},{"issue":"3","key":"9939_CR10","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/WCO.0b013e32832b4db3","volume":"22","author":"TJ Kleinig","year":"2009","unstructured":"Kleinig TJ, Vink R (2009) Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options. Curr Opin Neurol 22(3):294\u2013301","journal-title":"Curr Opin Neurol"},{"issue":"6","key":"9939_CR11","first-page":"347","volume":"27","author":"QS Lian","year":"1996","unstructured":"Lian QS, Zhang ZZ, Shangguan Z, Zhou L, Pi RB, Xiang RD, Han Y, Zhang XY (1996) Studies on the anti-arrhythmic effect of xanthotoxol in experimental animals. Chin Tradit Herb Drugs 27(6):347\u2013349","journal-title":"Chin Tradit Herb Drugs"},{"issue":"2","key":"9939_CR12","first-page":"102","volume":"29","author":"QS Lian","year":"1998","unstructured":"Lian QS, Zhang ZZ, Hu X, Zhou L, Ye HY, He W, Zhu ZP (1998) Studies on the anti-inflammatory effect of xanthotoxol in experimental animals. Chin Tradit Herb Drugs 29(2):102\u2013104","journal-title":"Chin Tradit Herb Drugs"},{"issue":"4","key":"9939_CR13","first-page":"319","volume":"28","author":"J Liu","year":"2005","unstructured":"Liu J, Lian Q, Zhou L, Zhou Q, He W, Zhu Z, Lai F (2005) Calcium antagonistic effect of xanthotoxol on isolated guinea pig atria. Zhong Yao Cai 28(4):319\u2013321","journal-title":"Zhong Yao Cai"},{"issue":"1","key":"9939_CR14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","volume":"20","author":"EZ Longa","year":"1989","unstructured":"Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20(1):84\u201391","journal-title":"Stroke"},{"issue":"8","key":"9939_CR15","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0024-3205(99)00642-6","volume":"66","author":"TB Ng","year":"2000","unstructured":"Ng TB, Liu F, Wang ZT (2000) Antioxidative activity of natural products from plants. Life Sci 66(8):709\u2013723","journal-title":"Life Sci"},{"issue":"8","key":"9939_CR16","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1523\/JNEUROSCI.17-08-02746.1997","volume":"17","author":"S Nogawa","year":"1997","unstructured":"Nogawa S, Zhang F, Ross ME, Iadecola C (1997) Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 17(8):2746\u20132755","journal-title":"J Neurosci"},{"issue":"18","key":"9939_CR17","doi-asserted-by":"crossref","first-page":"10966","DOI":"10.1073\/pnas.95.18.10966","volume":"95","author":"S Nogawa","year":"1998","unstructured":"Nogawa S, Forster C, Zhang F, Nagayama M, Ross ME, Iadecola C (1998) Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia. Proc Natl Acad Sci USA 95(18):10966\u201310971","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"9939_CR18","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/WCO.0b013e3282ffafbf","volume":"21","author":"M Rodr\u00edguez-Y\u00e1\u00f1ez","year":"2008","unstructured":"Rodr\u00edguez-Y\u00e1\u00f1ez M, Castillo J (2008) Role of inflammatory markers in brain ischemia. Curr Opin Neurol 21(3):353\u2013357","journal-title":"Curr Opin Neurol"},{"issue":"15","key":"9939_CR19","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.1073\/pnas.90.15.7240","volume":"90","author":"D Salvemini","year":"1993","unstructured":"Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P (1993) Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci USA 90(15):7240\u20137244","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"9939_CR20","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0378-8741(92)90050-2","volume":"36","author":"OP Sethi","year":"1992","unstructured":"Sethi OP, Anand KK, Gulati OD (1992) Evaluation of xanthotoxol for central nervous system activity. J Ethnopharmacol 36(3):239\u2013247","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"9939_CR21","first-page":"45","volume":"8","author":"Z Shangguan","year":"1997","unstructured":"Shangguan Z, Lian QS, Zeng J, Zhou Q, Pi RB, Liu JX, Yang JG (1997) Studies on the analgesic effect of xanthotoxol in experimental animals. Tradit Chin Drug Res Clin Pharmacol 8(1):45\u201346","journal-title":"Tradit Chin Drug Res Clin Pharmacol"},{"issue":"3","key":"9939_CR22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2174\/156652309788488569","volume":"9","author":"SW Tas","year":"2009","unstructured":"Tas SW, Vervoordeldonk MJ, Tak PP (2009) Gene therapy targeting nuclear factor-kappaB: towards clinical application in inflammatory diseases and cancer. Curr Gene Ther 9(3):160\u2013170","journal-title":"Curr Gene Ther"},{"issue":"1","key":"9939_CR23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1124\/pr.108.000547","volume":"61","author":"N Toda","year":"2009","unstructured":"Toda N, Ayajiki K, Okamura T (2009) Cerebral blood flow regulation by nitric oxide: recent advances. Pharmacol Rev 61(1):62\u201397","journal-title":"Pharmacol Rev"},{"key":"9939_CR24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.pharmtox.38.1.97","volume":"38","author":"JR Vane","year":"1998","unstructured":"Vane JR, Bakhle YS, Botting RM (1998) Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 38:97\u2013120","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"3\u20134","key":"9939_CR25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2119\/2007-00008.Villa","volume":"13","author":"P Villa","year":"2007","unstructured":"Villa P, Triulzi S, Cavalieri B, Di Bitondo R, Bertini R, Barbera S, Bigini P, Mennini T, Gelosa P, Tremoli E, Sironi L, Ghezzi P (2007) The interleukin-8 (IL-8\/CXCL8) receptor inhibitor reparixin improves neurological deficits and reduces long-term inflammation in permanent and transient cerebral ischemia in rats. Mol Med 13(3\u20134):125\u2013133","journal-title":"Mol Med"},{"issue":"1\u20132","key":"9939_CR26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jneuroim.2006.11.014","volume":"184","author":"Q Wang","year":"2007","unstructured":"Wang Q, Tang XN, Yenari MA (2007) The inflammatory response in stroke. J Neuroimmunol 184(1\u20132):53\u201368","journal-title":"J Neuroimmunol"},{"issue":"9","key":"9939_CR27","first-page":"14","volume":"15","author":"RD Xiang","year":"1984","unstructured":"Xiang RD, Fu XH (1984) Studies on the chemical constituents of common cnidium(cnidium monnieri)(I). Chin Tradit Herb Drugs 15(9):14\u201315","journal-title":"Chin Tradit Herb Drugs"},{"issue":"11","key":"9939_CR28","first-page":"809","volume":"26","author":"J Zeng","year":"2003","unstructured":"Zeng J, Lian Q, Zhou Q, Zhou L, Ye H, Huang X (2003) Effect of xanthotoxol on contraction of rabbit thoracic aortic strips. Zhong Yao Cai 26(11):809\u2013811","journal-title":"Zhong Yao Cai"},{"issue":"1","key":"9939_CR29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/sj.jcbfm.9600004","volume":"25","author":"W Zhang","year":"2005","unstructured":"Zhang W, Potrovita I, Tarabin V, Herrmann O, Beer V, Weih F, Schneider A, Schwaninger M (2005) Neuronal activation of NF-kappaB contributes to cell death in cerebral ischemia. J Cereb Blood Flow Metab 25(1):30\u201340","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-013-9939-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10571-013-9939-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-013-9939-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T17:51:48Z","timestamp":1715277108000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10571-013-9939-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,26]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["9939"],"URL":"https:\/\/doi.org\/10.1007\/s10571-013-9939-2","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,26]]}}}