{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T06:32:42Z","timestamp":1785047562119,"version":"3.55.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T00:00:00Z","timestamp":1389225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s10571-014-0025-1","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:41:36Z","timestamp":1389202896000},"page":"403-408","source":"Crossref","is-referenced-by-count":33,"title":["Piperine Reverses Chronic Unpredictable Mild Stress-Induced Behavioral and Biochemical Alterations in Rats"],"prefix":"10.1007","volume":"34","author":[{"given":"Qing-Qiu","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ming","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Fang","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siu-Po","family":"Ip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,9]]},"reference":[{"key":"25_CR1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.fct.2009.12.009","volume":"48","author":"P Chonpathompikunlert","year":"2010","unstructured":"Chonpathompikunlert P, Wattanathorn J, Muchimapura S (2010) Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer\u2019s disease. Food Chem Toxicol 48:798\u2013802","journal-title":"Food Chem Toxicol"},{"key":"25_CR2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1006\/phrs.1999.0640","volume":"41","author":"SK Gupta","year":"2000","unstructured":"Gupta SK, Bansal P, Bhardwaj RK, Velpandian T (2000) Comparative antinociceptive, anti-inflammatory and toxicity profile of nimesulide vs nimesulide and piperine combination. Pharmacol Res 41:657\u2013662","journal-title":"Pharmacol Res"},{"key":"25_CR3","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","volume":"24","author":"EJ Huang","year":"2001","unstructured":"Huang EJ, Reichardt LF (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677\u2013736","journal-title":"Annu Rev Neurosci"},{"key":"25_CR4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbr.2009.03.040","volume":"202","author":"Y Ibarguen-Vargas","year":"2009","unstructured":"Ibarguen-Vargas Y, Surget A, Vourc\u2019h P, Leman S, Andres CR, Gardier AM, Belzung C (2009) Deficit in BDNF does not increase vulnerability to stress but dampens antidepressant-like effects in the unpredictable chronic mild stress. Behav Brain Res 202:245\u2013251","journal-title":"Behav Brain Res"},{"key":"25_CR5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0091-3057(03)00044-3","volume":"75","author":"AS Ivy","year":"2003","unstructured":"Ivy AS, Rodriguez FG, Garcia C, Chen MJ, Russo-Neustadt AA (2003) Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant. Pharmacol Biochem Behav 75:81\u201388","journal-title":"Pharmacol Biochem Behav"},{"key":"25_CR6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.brainres.2006.06.008","volume":"1108","author":"DM Juric","year":"2006","unstructured":"Juric DM, Miklic S, Carman-Krzan M (2006) Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes. Brain Res 1108:54\u201362","journal-title":"Brain Res"},{"key":"25_CR7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jep.2004.01.013","volume":"91","author":"LD Kong","year":"2004","unstructured":"Kong LD, Cheng CH, Tan RX (2004) Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones. J Ethnopharmacol 91:351\u2013355","journal-title":"J Ethnopharmacol"},{"key":"25_CR8","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","volume":"2008","author":"V Krishnan","year":"2008","unstructured":"Krishnan V, Nestler EJ (2008) The molecular neurobiology of depression. Nature 2008:894\u2013902","journal-title":"Nature"},{"key":"25_CR9","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1248\/cpb.53.832","volume":"53","author":"SA Lee","year":"2005","unstructured":"Lee SA, Hong SS, Han XH, Hwang JS, Oh GJ, Lee KS, Lee MK, Hwang BY, Ro JS (2005) Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity. Chem Pharm Bull 53:832\u2013835","journal-title":"Chem Pharm Bull"},{"key":"25_CR10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/10286020500384302","volume":"9","author":"S Li","year":"2007","unstructured":"Li S, Wang C, Li W, Koike K, Nikaido T, Wang MW (2007a) Antidepressant-like effects of piperine and its derivative, antiepilepsirine. J Asian Nat Prod Res 9:421\u2013430","journal-title":"J Asian Nat Prod Res"},{"key":"25_CR11","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.lfs.2006.12.027","volume":"80","author":"S Li","year":"2007","unstructured":"Li S, Wang C, Wang M, Li W, Matsumoto K, Tang Y (2007b) Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sci 80:1373\u20131381","journal-title":"Life Sci"},{"key":"25_CR12","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.pnpbp.2009.07.002","volume":"33","author":"QQ Mao","year":"2009","unstructured":"Mao QQ, Ip SP, Ko KM, Tsai SH, Che CT (2009) Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic\u2013pituitary\u2013adrenal function and brain-derived neurotrophic factor. Prog Neuropsychopharmacol Biol Psychiatry 33:1211\u20131216","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"25_CR13","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jep.2010.01.050","volume":"128","author":"QQ Mao","year":"2010","unstructured":"Mao QQ, Huang Z, Zhong XM, Feng CR, Pan AJ, Li ZY, Ip SP, Che CT (2010a) Effects of SYJN, a Chinese herbal formula, on chronic unpredictable stress-induced changes in behavior and brain BDNF in rats. J Ethnopharmacol 128:336\u2013341","journal-title":"J Ethnopharmacol"},{"key":"25_CR14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bbr.2010.02.026","volume":"210","author":"QQ Mao","year":"2010","unstructured":"Mao QQ, Xian YF, Ip SP, Tsai SH, Che CT (2010b) Long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in rat brain. Behav Brain Res 210:171\u2013177","journal-title":"Behav Brain Res"},{"key":"25_CR15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neulet.2011.09.038","volume":"504","author":"QQ Mao","year":"2011","unstructured":"Mao QQ, Huang Z, Ip SP, Xian YF, Che CT (2011a) Role of 5-HT(1A) and 5-HT(1B) receptors in the antidepressant-like effect of piperine in the forced swim test. Neurosci Lett 504:181\u2013184","journal-title":"Neurosci Lett"},{"key":"25_CR16","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.pnpbp.2011.03.017","volume":"35","author":"QQ Mao","year":"2011","unstructured":"Mao QQ, Xian YF, Ip SP, Che CT (2011b) Involvement of serotonergic system in the antidepressant-like effect of piperine. Prog Neuropsychopharmacol Biol Psychiatry 35:1144\u20131147","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"25_CR17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bbr.2011.11.016","volume":"227","author":"QQ Mao","year":"2012","unstructured":"Mao QQ, Huang Z, Ip SP, Xian YF, Che CT (2012) Peony glycosides reverse the effects of corticosterone on behavior and brain BDNF expression in rats. Behav Brain Res 227:305\u2013309","journal-title":"Behav Brain Res"},{"key":"25_CR18","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.tins.2004.08.001","volume":"27","author":"MP Mattson","year":"2004","unstructured":"Mattson MP, Maudsley S, Martin B (2004) BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 27:589\u2013594","journal-title":"Trends Neurosci"},{"key":"25_CR19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.biopsych.2006.03.021","volume":"61","author":"LM Monteggia","year":"2007","unstructured":"Monteggia LM, Luikart B, Barrot M, Theobold D, Malkovska I, Nef S, Parada LF, Nestler EJ (2007) Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biol Psychiatry 61:187\u2013197","journal-title":"Biol Psychiatry"},{"key":"25_CR20","first-page":"327","volume":"229","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Pichon MLE, Jalfre M (1977) Behavioral despair in mice: a primary screening test for antidepressant. Arch Int Pharmacodyn Ther 229:327\u2013336","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"25_CR21","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1176\/ajp.122.5.509","volume":"122","author":"JJ Schildkraut","year":"1965","unstructured":"Schildkraut JJ (1965) The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry 122:509\u2013522","journal-title":"Am J Psychiatry"},{"key":"25_CR22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0367-326X(02)00304-0","volume":"74","author":"K Selvendiran","year":"2003","unstructured":"Selvendiran K, Singh JP, Krishnan KB, Sakthisekaran D (2003) Cytoprotective effect of piperine against benzo[a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice. Fitoterapia 74:109\u2013115","journal-title":"Fitoterapia"},{"key":"25_CR23","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.pnpbp.2007.08.001","volume":"32","author":"M T\u00f5nissaar","year":"2008","unstructured":"T\u00f5nissaar M, M\u00e4llo T, Eller M, H\u00e4idkind R, K\u00f5iv K, Harro J (2008) Rat behavior after chronic variable stress and partial lesioning of 5-HT-ergic neurotransmission: effects of citalopram. Prog Neuropsychopharmacol Biol Psychiatry 32:164\u2013177","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"25_CR24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","volume":"134","author":"P Willner","year":"1997","unstructured":"Willner P (1997) Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology 134:319\u2013329","journal-title":"Psychopharmacology"},{"key":"25_CR25","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","volume":"52","author":"P Willner","year":"2005","unstructured":"Willner P (2005) Chronic mild stress (CMS) revisited: consistency and behavioural\u2013neurobiological concordance in the effects of CMS. Neuropsychobiology 52:90\u2013110","journal-title":"Neuropsychobiology"},{"key":"25_CR26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbr.2008.06.009","volume":"195","author":"J Zhou","year":"2008","unstructured":"Zhou J, Li L, Tang S, Cao X, Li Z, Li W, Li C, Zhang X (2008) Effects of serotonin depletion on the hippocampal GR\/MR and BDNF expression during the stress adaptation. Behav Brain Res 195:129\u2013138","journal-title":"Behav Brain Res"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-014-0025-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10571-014-0025-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-014-0025-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T18:10:17Z","timestamp":1559239817000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10571-014-0025-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,9]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["25"],"URL":"https:\/\/doi.org\/10.1007\/s10571-014-0025-1","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,9]]}}}