{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:02:23Z","timestamp":1768586543187,"version":"3.49.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T00:00:00Z","timestamp":1405641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1007\/s10571-014-0086-1","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T15:56:23Z","timestamp":1405612583000},"page":"1111-1121","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Protective Effects of Andrographis paniculata Extract and Pure Andrographolide Against Chronic Stress-Triggered Pathologies in Rats"],"prefix":"10.1007","volume":"34","author":[{"given":"Ajit Kumar","family":"Thakur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Upendra Kumar","family":"Soni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geeta","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam Sunder","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,7,18]]},"reference":[{"key":"86_CR1","first-page":"443","volume":"73","author":"KP Bhargava","year":"1981","unstructured":"Bhargava KP, Singh N (1981) Anti-stress activity of Ocimum sanctum Linn. Indian J Med Res 73:443\u2013451","journal-title":"Indian J Med Res"},{"key":"86_CR2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0091-3057(03)00110-2","volume":"75","author":"SK Bhattacharya","year":"2003","unstructured":"Bhattacharya SK, Muruganandam AV (2003) Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav 75:547\u2013555","journal-title":"Pharmacol Biochem Behav"},{"key":"86_CR3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/1365-2435.12008","volume":"27","author":"R Boonstra","year":"2013","unstructured":"Boonstra R (2013) Reality as the leading cause of stress: rethinking the impact of chronic stress in nature. Funct Ecol 27:11\u201323","journal-title":"Funct Ecol"},{"key":"86_CR4","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1016\/j.fct.2009.05.006","volume":"47","author":"CV Chandrasekaran","year":"2009","unstructured":"Chandrasekaran CV, Thiyagarajan P, Sundarajan K, Goudar KS, Deepak M, Murali B, Allan JJ, Agarwal A (2009) Evaluation of the genotoxic potential and acute oral toxicity of standardized extract of Andrographis paniculata (KalmCold\u2122). Food Chem Toxicol 47:1892\u20131902","journal-title":"Food Chem Toxicol"},{"key":"86_CR5","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jep.2010.03.007","volume":"129","author":"CV Chandrasekaran","year":"2010","unstructured":"Chandrasekaran CV, Gupta A, Agarwal A (2010) Effect of an extract of Andrographis paniculata leaves on inflammatory and allergic mediators in vitro. J Ethnopharmacol 129:203\u2013207","journal-title":"J Ethnopharmacol"},{"key":"86_CR6","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1177\/0192623312466452","volume":"41","author":"NE Everds","year":"2013","unstructured":"Everds NE, Snyder PW, Bailey KL, Bolon B, Creasy DM, Foley GL, Rosol TJ, Sellers T (2013) Interpreting stress responses during routine toxicity studies: a review of the biology, impact, and assessment. Toxicol Pathol 41:560\u2013614","journal-title":"Toxicol Pathol"},{"key":"86_CR7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jep.2005.02.035","volume":"99","author":"R Govindarajan","year":"2005","unstructured":"Govindarajan R, Vijayakumar M, Pushpangadan P (2005) Antioxidant approach to disease management and the role of \u2018Rasayana\u2019 herbs of Ayurveda. J Ethnopharmacol 99:165\u2013178","journal-title":"J Ethnopharmacol"},{"key":"86_CR8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbi.2013.10.021","volume":"37c","author":"MB Hennessy","year":"2014","unstructured":"Hennessy MB, Deak T, Schiml PA (2014) Sociality and sickness: have cytokines evolved to serve social functions beyond times of pathogen exposure? Brain Behav Immun 37c:15\u201320","journal-title":"Brain Behav Immun"},{"key":"86_CR9","first-page":"247","volume-title":"Innovative Rheumatology","author":"MA Hidalgo","year":"2013","unstructured":"Hidalgo MA, Hanke JL, Bertoglio JC, Burgos RA (2013) Andrographolide a new potential drug for long term treatment of Rheumatoid Arthritis disease. In: Matsuno H (ed) Innovative Rheumatology. InTech, Croatia, pp 247\u2013270"},{"key":"86_CR10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbi.2013.10.016","volume":"36","author":"D Hu","year":"2014","unstructured":"Hu D, Wan L, Chen M, Caudle Y, LeSage G, Li Q, Yin D (2014) Essential role of IL-10\/STAT3 in chronic stress-induced immune suppression. Brain Behav Immun 36:118\u2013127","journal-title":"Brain Behav Immun"},{"key":"86_CR11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.physbeh.2013.10.035","volume":"124","author":"CM Hueston","year":"2014","unstructured":"Hueston CM, Deak T (2014) The inflamed axis: the interaction between stress, hormones, and the expression of inflammatory-related genes within key structures comprising the hypothalamic\u2013pituitary\u2013adrenal axis. Physiol Behav 124:77\u201391","journal-title":"Physiol Behav"},{"key":"86_CR12","doi-asserted-by":"crossref","unstructured":"Jayakumar T, Hsieh CY, Lee JJ, Sheu JR (2013) Experimental and clinical pharmacology of Andrographis paniculata and its major bioactive phytoconstituent andrographolide. Evid Based Complement Alternat Med. Article ID: 846740. doi: 10.1155\/2013\/846740","DOI":"10.1155\/2013\/846740"},{"key":"86_CR13","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.neubiorev.2011.02.003","volume":"35","author":"JM Koolhaas","year":"2011","unstructured":"Koolhaas JM, Bartolomucci A, Buwalda B, de Boer SF, Fl\u00fcgge G, Korte SM, Meerlo P, Murison R, Olivier B, Palanza P, Richter-Levin G, Sgoifo A, Steimer T, Stiedl O, van Dijk G, W\u00f6hr M, Fuchs E (2011) Stress revisited: a critical evaluation of the stress concept. Neurosci Biobehav Rev 35:1291\u20131301","journal-title":"Neurosci Biobehav Rev"},{"key":"86_CR14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neubiorev.2004.08.009","volume":"29","author":"SM Korte","year":"2005","unstructured":"Korte SM, Koolhaas JM, Wingfield JC, McEwen BS (2005) The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. Neurosci Biobehav Rev 29:3\u201338","journal-title":"Neurosci Biobehav Rev"},{"key":"86_CR15","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1440-1681.2011.05633.x","volume":"39","author":"JC Lim","year":"2012","unstructured":"Lim JC, Chan TK, Ng DS, Sagineedu SR, Stanslas J, Wong WS (2012) Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. Clin Exp Pharmacol Physiol 39:300\u2013310","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"86_CR16","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ejim.2011.11.016","volume":"23","author":"D Lucini","year":"2012","unstructured":"Lucini D, Pagani M (2012) From stress to functional syndromes: an internist\u2019s point of view. Eur J Intern Med 23:295\u2013301","journal-title":"Eur J Intern Med"},{"key":"86_CR17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/ptr.2650070114","volume":"7","author":"S Morishita","year":"1993","unstructured":"Morishita S, Shoji M, Oguni Y, Hirai Y, Sugimoto C, Ito C (1993) Effects of crude drugs derived from animal sources on sexual and learning behaviour in chronically stressed mice. Phytother Res 7:57\u201363","journal-title":"Phytother Res"},{"key":"86_CR18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-3-7091-0442-2_4","volume-title":"Evidence and rational based research on Chinese drugs","author":"A Panossian","year":"2013","unstructured":"Panossian A, Wikman G (2013) Efficacy of Andrographis paniculata in upper respiratory tract infectious diseases and the mechanism of action. In: Wagner H, Ulrich-Merzenich G (eds) Evidence and rational based research on Chinese drugs. Springer, Vienna, pp 137\u2013179"},{"key":"86_CR19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","volume":"47","author":"RD Porsolt","year":"1978","unstructured":"Porsolt RD, Anton G, Blavet N, Jalfre M (1978) Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 47:379\u2013391","journal-title":"Eur J Pharmacol"},{"key":"86_CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psyneuen.2011.05.014","volume":"37","author":"SO Reber","year":"2012","unstructured":"Reber SO (2012) Stress and animal models of inflammatory bowel disease\u2014an update on the role of the hypothalamo\u2013pituitary\u2013adrenal axis. Psychoneuroendocrinology 37:1\u201319","journal-title":"Psychoneuroendocrinology"},{"key":"86_CR21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","volume":"10","author":"M Saraiva","year":"2010","unstructured":"Saraiva M, O\u2019Garra A (2010) The regulation of IL-10 production by immune cells. Nat Rev Immunol 10:170\u2013181","journal-title":"Nat Rev Immunol"},{"key":"86_CR22","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.phymed.2009.12.001","volume":"17","author":"RC Saxena","year":"2010","unstructured":"Saxena RC, Singh R, Kumar P, Yadav SC, Negi MP, Saxena VS, Joshua AJ, Vijayabalaji V, Goudar KS, Venkateshwarlu K, Amit A (2010) A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold\u2122) in patients with uncomplicated upper respiratory tract infection. Phytomedicine 17:178\u2013185","journal-title":"Phytomedicine"},{"key":"86_CR23","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.phymed.2005.01.009","volume":"12","author":"B Singh","year":"2005","unstructured":"Singh B, Chandan BK, Sharma N, Singh S, Khajuria A, Gupta DK (2005) Adaptogenic activity of glyco-peptido-lipid fraction from the alcoholic extract of Trichopus zeylanicus Gaerten (part II). Phytomedicine 12:468\u2013481","journal-title":"Phytomedicine"},{"key":"86_CR24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4236\/cm.2012.31009","volume":"3","author":"GK Singh","year":"2012","unstructured":"Singh GK, Rai G, Chatterjee SS, Kumar V (2012) Beneficial effects of Fumaria indica on chronic stress-induced neurobehavioral and biochemical perturbations in rats. Chin Med 3:49\u201360","journal-title":"Chin Med"},{"key":"86_CR25","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4103\/0974-8520.127727","volume":"34","author":"GK Singh","year":"2013","unstructured":"Singh GK, Rai G, Chatterjee SS, Kumar V (2013) Effects of ethanolic extract of Fumaria indica L. on rat cognitive dysfunctions. Ayu 34:421\u2013429","journal-title":"Ayu"},{"key":"86_CR26","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s13596-013-0140-4","volume":"14","author":"AK Thakur","year":"2014","unstructured":"Thakur AK, Chatterjee SS, Kumar V (2014a) Neuropsychopharmacology of a therapeutically used Andrographis paniculata extract: a preclinical study. Orient Pharm Exp Med 14:181\u2013191","journal-title":"Orient Pharm Exp Med"},{"key":"86_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5667\/tang.2014.0001","volume":"4","author":"AK Thakur","year":"2014","unstructured":"Thakur AK, Chatterjee SS, Kumar V (2014b) Therapeutic potential of traditionally used medicinal plant Andrographis paniculata (Burm. F.) against diabesity: an experimental study in rats. TANG: Int J Genuine Tradit Med 4:1\u20138","journal-title":"TANG: Int J Genuine Tradit Med"},{"key":"86_CR28","doi-asserted-by":"crossref","unstructured":"Thakur AK, Chatterjee SS, Kumar V (2014c) Adaptogenic potential of Andrographolide: an active principle of the King of Bitters (Andrographis paniculata). J Tradit Complement Med (in press)","DOI":"10.1016\/j.jtcme.2014.10.002"},{"key":"86_CR29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1192\/S0007125000296670","volume":"160","author":"MH Thiebot","year":"1992","unstructured":"Thiebot MH, Martin P, Puech AJ (1992) Animal behavioural studies in the evaluation of antidepressant drugs. Br J Psychiatry Suppl 160:44\u201350","journal-title":"Br J Psychiatry Suppl"},{"key":"86_CR30","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1007\/s11033-011-1341-x","volume":"39","author":"A Valdiani","year":"2012","unstructured":"Valdiani A, Kadir MA, Tan SG, Talei D, Abdullah MP, Nikzad S (2012) Nain-e Havandi Andrographis paniculata present yesterday, absent today: a plenary review on underutilized herb of Iran\u2019s pharmaceutical plants. Mol Biol Rep 39:5409\u20135424","journal-title":"Mol Biol Rep"},{"key":"86_CR31","volume-title":"Major herbs of Ayurveda","author":"EM Williamson","year":"2002","unstructured":"Williamson EM (2002) Major herbs of Ayurveda. Churchill Livingstone, China"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-014-0086-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10571-014-0086-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-014-0086-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T11:54:48Z","timestamp":1649678088000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10571-014-0086-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,18]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["86"],"URL":"https:\/\/doi.org\/10.1007\/s10571-014-0086-1","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,18]]}}}