{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:59:20Z","timestamp":1781971160061,"version":"3.54.5"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Scholarship from Coordination for the Improvement of Higher Education Personnel (CAPES)"},{"name":"CNPq (The National Council for Scientific and Technological Development) fellow researcher"},{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["2012\/50336-2"],"award-info":[{"award-number":["2012\/50336-2"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s10571-016-0378-8","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T10:27:00Z","timestamp":1462184820000},"page":"453-460","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Thiamine Deficiency Increases Ca2+ Current and CaV1.2 L-type Ca2+ Channel Levels in Cerebellum Granular Neurons"],"prefix":"10.1007","volume":"37","author":[{"given":"Daniel C.","family":"Moreira-Lobo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jader S.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia R.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fab\u00edola M.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Kushmerick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando A.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,2]]},"reference":[{"issue":"5","key":"378_CR1","doi-asserted-by":"crossref","first-page":"R157","DOI":"10.1016\/S0960-9822(99)80101-8","volume":"9","author":"M Berridge","year":"1999","unstructured":"Berridge M, Lipp P, Bootman M (1999) Calcium signalling. Curr Biol 9(5):R157\u2013159","journal-title":"Curr Biol"},{"issue":"1","key":"378_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/35036035","volume":"1","author":"MJ Berridge","year":"2000","unstructured":"Berridge MJ, Lipp P, Bootman MD (2000) The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 1(1):11\u201321. doi: 10.1038\/35036035","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"Pt 12","key":"378_CR3","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1242\/jcs.114.12.2213","volume":"114","author":"MD Bootman","year":"2001","unstructured":"Bootman MD, Lipp P, Berridge MJ (2001) The organisation and functions of local Ca(2+) signals. J Cell Sci 114(Pt 12):2213\u20132222","journal-title":"J Cell Sci"},{"issue":"Suppl 3","key":"378_CR4","first-page":"S123","volume":"20","author":"RF Butterworth","year":"1993","unstructured":"Butterworth RF (1993) Pathophysiology of cerebellar dysfunction in the Wernicke-Korsakoff syndrome. Can J Neurol Sci 20(Suppl 3):S123\u2013126","journal-title":"Can J Neurol Sci"},{"issue":"2","key":"378_CR5","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nrn3648","volume":"15","author":"P Chadderton","year":"2014","unstructured":"Chadderton P, Schaefer AT, Williams SR, Margrie TW (2014) Sensory-evoked synaptic integration in cerebellar and cerebral cortical neurons. Nat Rev Neurosci 15(2):71\u201383. doi: 10.1038\/nrn3648","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"378_CR6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.18388\/abp.2007_3252","volume":"54","author":"S Chornyy","year":"2007","unstructured":"Chornyy S, Parkhomenko J, Chorna N (2007) Thiamine deficiency caused by thiamine antagonists triggers upregulation of apoptosis inducing factor gene expression and leads to caspase 3-mediated apoptosis in neuronally differentiated rat PC-12 cells. Acta Biochim Pol 54(2):315\u2013322","journal-title":"Acta Biochim Pol"},{"key":"378_CR7","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neuroscience.2012.06.053","volume":"221","author":"JS Cruz","year":"2012","unstructured":"Cruz JS, Kushmerick C, Moreira-Lobo DC, Oliveira FA (2012) Thiamine deficiency in vitro accelerates A-type potassium current inactivation in cerebellar granule neurons. Neuroscience 221:108\u2013114. doi: 10.1016\/j.neuroscience.2012.06.053","journal-title":"Neuroscience"},{"issue":"3","key":"378_CR8","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1523\/JNEUROSCI.21-03-00759.2001","volume":"21","author":"E D\u2019Angelo","year":"2001","unstructured":"D\u2019Angelo E, Nieus T, Maffei A, Armano S, Rossi P, Taglietti V, Fontana A, Naldi G (2001) Theta-frequency bursting and resonance in cerebellar granule cells: experimental evidence and modeling of a slow k+-dependent mechanism. J Neurosci 21(3):759\u2013770","journal-title":"J Neurosci"},{"issue":"1\u20132","key":"378_CR9","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0006-8993(94)90041-8","volume":"643","author":"RM Davidson","year":"1994","unstructured":"Davidson RM, Shajenko L, Donta TS (1994) Amyloid beta-peptide (A beta P) potentiates a nimodipine-sensitive L-type barium conductance in N1E-115 neuroblastoma cells. Brain Res 643(1\u20132):324\u2013327","journal-title":"Brain Res"},{"issue":"8","key":"378_CR10","doi-asserted-by":"publisher","first-page":"E295","DOI":"10.1503\/cmaj.130091","volume":"186","author":"GS Day","year":"2014","unstructured":"Day GS, del Campo CM (2014) Wernicke encephalopathy: a medical emergency. CMAJ 186(8):E295. doi: 10.1503\/cmaj.130091","journal-title":"CMAJ"},{"issue":"12","key":"378_CR11","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1111\/j.1468-1331.2010.03153.x","volume":"17","author":"R Galvin","year":"2010","unstructured":"Galvin R, Br\u00e5then G, Ivashynka A, Hillbom M, Tanasescu R, Leone MA (2010) EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. Eur J Neurol 17(12):1408\u20131418. doi: 10.1111\/j.1468-1331.2010.03153.x","journal-title":"Eur J Neurol"},{"issue":"7","key":"378_CR12","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1089\/ars.2010.3386","volume":"14","author":"M Gleichmann","year":"2011","unstructured":"Gleichmann M, Mattson MP (2011) Neuronal calcium homeostasis and dysregulation. Antioxid Redox Signal 14(7):1261\u20131273. doi: 10.1089\/ars.2010.3386","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"378_CR100","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","volume":"391","author":"OP Hamill","year":"1981","unstructured":"Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflug Arch Eur J Phy 391(2):85\u2013100","journal-title":"Pflug Arch Eur J Ph"},{"issue":"6","key":"378_CR13","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/(SICI)1097-4547(19980615)52:6<742::AID-JNR13>3.0.CO;2-0","volume":"52","author":"AS Hazell","year":"1998","unstructured":"Hazell AS, Hakim AM, Senterman MK, Hogan MJ (1998) Regional activation of L-type voltage-sensitive calcium channels in experimental thiamine deficiency. J Neurosci Res 52(6):742\u2013749","journal-title":"J Neurosci Res"},{"issue":"6","key":"378_CR14","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1162\/neco.1997.9.6.1179","volume":"9","author":"ML Hines","year":"1997","unstructured":"Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9(6):1179\u20131209","journal-title":"Neural Comput"},{"issue":"11","key":"378_CR15","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1007\/s11064-010-0249-5","volume":"35","author":"KD Kang","year":"2010","unstructured":"Kang KD, Majid AS, Kim KA, Kang K, Ahn HR, Nho CW, Jung SH (2010) Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells. Neurochem Res 35(11):1828\u20131839. doi: 10.1007\/s11064-010-0249-5","journal-title":"Neurochem Res"},{"key":"378_CR16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3389\/fphar.2012.00061","volume":"3","author":"EM Kawamoto","year":"2012","unstructured":"Kawamoto EM, Vivar C, Camandola S (2012) Physiology and pathology of calcium signaling in the brain. Front Pharmacol 3:61. doi: 10.3389\/fphar.2012.00061","journal-title":"Front Pharmacol"},{"issue":"3","key":"378_CR17","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s10059-011-0075-x","volume":"32","author":"S Kim","year":"2011","unstructured":"Kim S, Rhim H (2011) Effects of amyloid-beta peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels. Mol Cells 32(3):289\u2013294. doi: 10.1007\/s10059-011-0075-x","journal-title":"Mol Cells"},{"issue":"1","key":"378_CR18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.neulet.2004.07.047","volume":"369","author":"MJ Kim","year":"2004","unstructured":"Kim MJ, Chung YH, Joo KM, Oh GT, Kim J, Lee B, Cha CI (2004) Immunohistochemical study of the distribution of neuronal voltage-gated calcium channels in the nNOS knock-out mouse cerebellum. Neurosci Lett 369(1):39\u201343. doi: 10.1016\/j.neulet.2004.07.047","journal-title":"Neurosci Lett"},{"key":"378_CR19","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1750-1326-5-54","volume":"5","author":"S Lee","year":"2010","unstructured":"Lee S, Yang G, Yong Y, Liu Y, Zhao L, Xu J, Zhang X, Wan Y, Feng C, Fan Z, Liu Y, Luo J, Ke ZJ (2010) ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics. Mol Neurodegener 5:54. doi: 10.1186\/1750-1326-5-54","journal-title":"Mol Neurodegener"},{"issue":"7","key":"378_CR20","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1074\/jbc.275.7.4713","volume":"275","author":"A MacManus","year":"2000","unstructured":"MacManus A, Ramsden M, Murray M, Henderson Z, Pearson HA, Campbell VA (2000) Enhancement of (45)Ca(2+) influx and voltage-dependent Ca(2+) channel activity by beta-amyloid-(1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1beta. J Biol Chem 275(7):4713\u20134718","journal-title":"J Biol Chem"},{"issue":"5","key":"378_CR21","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1016\/S0006-3495(00)76809-3","volume":"78","author":"M Maravall","year":"2000","unstructured":"Maravall M, Mainen ZF, Sabatini BL, Svoboda K (2000) Estimating intracellular calcium concentrations and buffering without wavelength ratioing. Biophys J 78(5):2655\u20132667. doi: 10.1016\/S0006-3495(00)76809-3","journal-title":"Biophys J"},{"issue":"3","key":"378_CR22","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/j.1474-9726.2007.00275.x","volume":"6","author":"MP Mattson","year":"2007","unstructured":"Mattson MP (2007) Calcium and neurodegeneration. Aging Cell 6(3):337\u2013350. doi: 10.1111\/j.1474-9726.2007.00275.x","journal-title":"Aging Cell"},{"issue":"1","key":"378_CR23","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1080\/14734220600551707","volume":"5","author":"PJ Mulholland","year":"2006","unstructured":"Mulholland PJ (2006) Susceptibility of the cerebellum to thiamine deficiency. Cerebellum 5(1):55\u201363. doi: 10.1080\/14734220600551707","journal-title":"Cerebellum"},{"key":"378_CR24","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3389\/neuro.24.002.2010","volume":"2","author":"MM Oh","year":"2010","unstructured":"Oh MM, Oliveira FA, Disterhoft JF (2010) Learning and aging related changes in intrinsic neuronal excitability. Front Aging Neurosci 2:2. doi: 10.3389\/neuro.24.002.2010","journal-title":"Front Aging Neurosci"},{"issue":"18","key":"378_CR25","doi-asserted-by":"publisher","first-page":"7905","DOI":"10.1523\/JNEUROSCI.5457-12.2013","volume":"33","author":"MM Oh","year":"2013","unstructured":"Oh MM, Oliveira FA, Waters J, Disterhoft JF (2013) Altered calcium metabolism in aging CA1 hippocampal pyramidal neurons. J Neurosci 33(18):7905\u20137911. doi: 10.1523\/JNEUROSCI.5457-12.2013","journal-title":"J Neurosci"},{"issue":"1","key":"378_CR26","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.brainres.2006.11.064","volume":"1134","author":"FA Oliveira","year":"2007","unstructured":"Oliveira FA, Galan DT, Ribeiro AM, Santos Cruz J (2007) Thiamine deficiency during pregnancy leads to cerebellar neuronal death in rat offspring: role of voltage-dependent K+ channels. Brain Res 1134(1):79\u201386. doi: 10.1016\/j.brainres.2006.11.064","journal-title":"Brain Res"},{"issue":"3","key":"378_CR27","doi-asserted-by":"publisher","first-page":"288","DOI":"10.4239\/wjd.v5.i3.288","volume":"5","author":"L P\u00e1cal","year":"2014","unstructured":"P\u00e1cal L, Kuricov\u00e1 K, Ka\u0148kov\u00e1 K (2014) Evidence for altered thiamine metabolism in diabetes: is there a potential to oppose gluco- and lipotoxicity by rational supplementation? World J Diabetes 5(3):288\u2013295. doi: 10.4239\/wjd.v5.i3.288","journal-title":"World J Diabetes"},{"issue":"2","key":"378_CR28","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/1097-4547(20001015)62:2<286::AID-JNR13>3.0.CO;2-0","volume":"62","author":"P Pannunzio","year":"2000","unstructured":"Pannunzio P, Hazell AS, Pannunzio M, Rao KV, Butterworth RF (2000) Thiamine deficiency results in metabolic acidosis and energy failure in cerebellar granule cells: an in vitro model for the study of cell death mechanisms in Wernicke\u2019s encephalopathy. J Neurosci Res 62(2):286\u2013292","journal-title":"J Neurosci Res"},{"issue":"4","key":"378_CR29","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1523\/JNEUROSCI.15-04-02995.1995","volume":"15","author":"A Randall","year":"1995","unstructured":"Randall A, Tsien RW (1995) Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons. J Neurosci 15(4):2995\u20133012","journal-title":"J Neurosci"},{"issue":"Pt 3","key":"378_CR30","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1113\/jphysiol.2003.060285","volume":"557","author":"E Sola","year":"2004","unstructured":"Sola E, Prestori F, Rossi P, Taglietti V, D\u2019Angelo E (2004) Increased neurotransmitter release during long-term potentiation at mossy fibre-granule cell synapses in rat cerebellum. J Physiol 557(Pt 3):843\u2013861. doi: 10.1113\/jphysiol.2003.060285","journal-title":"J Physiol"},{"issue":"2","key":"378_CR31","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.ceca.2010.01.003","volume":"47","author":"K Szydlowska","year":"2010","unstructured":"Szydlowska K, Tymianski M (2010) Calcium, ischemia and excitotoxicity. Cell Calcium 47(2):122\u2013129. doi: 10.1016\/j.ceca.2010.01.003","journal-title":"Cell Calcium"},{"issue":"6","key":"378_CR32","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1001\/archneur.1981.00510060052007","volume":"38","author":"JC Troncoso","year":"1981","unstructured":"Troncoso JC, Johnston MV, Hess KM, Griffin JW, Price DL (1981) Model of Wernicke\u2019s encephalopathy. Arch Neurol 38(6):350\u2013354","journal-title":"Arch Neurol"},{"issue":"5","key":"378_CR33","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1523\/JNEUROSCI.13-05-02085.1993","volume":"13","author":"M Tymianski","year":"1993","unstructured":"Tymianski M, Charlton MP, Carlen PL, Tator CH (1993) Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. J Neurosci 13(5):2085\u20132104","journal-title":"J Neurosci"},{"issue":"1","key":"378_CR34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1046\/j.1471-4159.1997.68010265.x","volume":"68","author":"K Ueda","year":"1997","unstructured":"Ueda K, Shinohara S, Yagami T, Asakura K, Kawasaki K (1997) Amyloid beta protein potentiates Ca2+ influx through L-type voltage-sensitive Ca2+ channels: a possible involvement of free radicals. J Neurochem 68(1):265\u2013271","journal-title":"J Neurochem"},{"issue":"2","key":"378_CR35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0169-328X(02)00643-5","volume":"110","author":"LM Veng","year":"2003","unstructured":"Veng LM, Mesches MH, Browning MD (2003) Age-related working memory impairment is correlated with increases in the L-type calcium channel protein alpha1D (Cav1.3) in area CA1 of the hippocampus and both are ameliorated by chronic nimodipine treatment. Brain Res Mol Brain Res 110(2):193\u2013202","journal-title":"Brain Res Mol Brain Res"},{"issue":"3","key":"378_CR36","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.neuroscience.2006.10.008","volume":"144","author":"X Wang","year":"2007","unstructured":"Wang X, Wang B, Fan Z, Shi X, Ke ZJ, Luo J (2007) Thiamine deficiency induces endoplasmic reticulum stress in neurons. Neuroscience 144(3):1045\u20131056. doi: 10.1016\/j.neuroscience.2006.10.008","journal-title":"Neuroscience"},{"issue":"10","key":"378_CR37","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/j.freeradbiomed.2010.02.031","volume":"48","author":"UC Yadav","year":"2010","unstructured":"Yadav UC, Kalariya NM, Srivastava SK, Ramana KV (2010) Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages. Free Radic Biol Med 48(10):1423\u20131434. doi: 10.1016\/j.freeradbiomed.2010.02.031","journal-title":"Free Radic Biol Med"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-016-0378-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10571-016-0378-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-016-0378-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-016-0378-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T15:26:12Z","timestamp":1655652372000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10571-016-0378-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,2]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["378"],"URL":"https:\/\/doi.org\/10.1007\/s10571-016-0378-8","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,2]]}}}