{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:04:13Z","timestamp":1761102253591,"version":"3.37.3"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T00:00:00Z","timestamp":1497571200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"The Ministry of Science and Technology of the P. R. China, National \u201c973\u201d project on Population and Health","award":["2007CB11901"],"award-info":[{"award-number":["2007CB11901"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270699","81070491"],"award-info":[{"award-number":["81270699","81070491"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s10571-017-0506-0","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T08:28:51Z","timestamp":1497601731000},"page":"605-614","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Quantitative Measurement of PARD3 Copy Number Variations in Human Neural Tube Defects"],"prefix":"10.1007","volume":"38","author":[{"given":"Yonghui","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaofang","family":"Shangguan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihua","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jizhen","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaohua","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,6,16]]},"reference":[{"key":"506_CR1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.bbamem.2007.08.029","volume":"1778","author":"E Assemat","year":"2008","unstructured":"Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D (2008) Polarity complex proteins. Biochim Biophys Acta 1778:614\u2013630","journal-title":"Biochim Biophys Acta"},{"key":"506_CR2","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/hmg\/dds515","volume":"22","author":"AG Bassuk","year":"2013","unstructured":"Bassuk AG, Muthuswamy LB, Boland R, Smith TL, Hulstrand AM, Northrup H, Hakeman M, Dierdorff JM, Yung CK, Long A, Brouillette RB, Au KS, Gurnett C, Houston DW, Cornell RA, Manak JR (2013) Copy number variation analysis implicates the cell polarity gene glypican 5 as a human spina bifida candidate gene. Hum Mol Genet 22:1097\u20131111","journal-title":"Hum Mol Genet"},{"key":"506_CR3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1028-4559(08)60002-9","volume":"46","author":"CP Chen","year":"2007","unstructured":"Chen CP (2007a) Chromosomal abnormalities associated with neural tube defects (I): full aneuploidy. Taiwan J Obstet Gynecol 46:325\u2013335","journal-title":"Taiwan J Obstet Gynecol"},{"key":"506_CR4","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S1028-4559(08)60003-0","volume":"46","author":"CP Chen","year":"2007","unstructured":"Chen CP (2007b) Chromosomal abnormalities associated with neural tube defects (II): partial aneuploidy. Taiwan J Obstet Gynecol 46:336\u2013351","journal-title":"Taiwan J Obstet Gynecol"},{"key":"506_CR5","doi-asserted-by":"crossref","first-page":"e54492","DOI":"10.1371\/journal.pone.0054492","volume":"8","author":"X Chen","year":"2013","unstructured":"Chen X, Shen Y, Gao Y, Zhao H, Sheng X, Zou J, Lip V, Xie H, Guo J, Shao H, Bao Y, Shen J, Niu B, Gusella JF, Wu BL, Zhang T (2013) Detection of copy number variants reveals association of cilia genes with neural tube defects. PLoS ONE 8:e54492","journal-title":"PLoS ONE"},{"key":"506_CR6","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/humu.23153","volume":"38","author":"X Chen","year":"2017","unstructured":"Chen X, An Y, Gao Y, Guo L, Rui L, Xie H, Sun M, Lam Hung S, Sheng X, Zou J, Bao Y, Guan H, Niu B, Li Z, Finnell RH, Gusella JF, Wu BL, Zhang T (2017) Rare deleterious PARD3 variants in the aPKC-binding region are implicated in the pathogenesis of human cranial neural tube defects via disrupting apical tight junction formation. Hum Mutat 38:378\u2013389","journal-title":"Hum Mutat"},{"key":"506_CR7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.conb.2009.04.010","volume":"19","author":"J Clarke","year":"2009","unstructured":"Clarke J (2009) Role of polarized cell divisions in zebrafish neural tube formation. Curr Opin Neurobiol 19:134\u2013138","journal-title":"Curr Opin Neurobiol"},{"key":"506_CR8","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ng.909","volume":"43","author":"GM Cooper","year":"2011","unstructured":"Cooper GM, Coe BP, Girirajan S, Rosenfeld JA, Vu TH, Baker C, Williams C, Stalker H, Hamid R, Hannig V, Abdel-Hamid H, Bader P, McCracken E, Niyazov D, Leppig K, Thiese H, Hummel M, Alexander N, Gorski J, Kussmann J, Shashi V, Johnson K, Rehder C, Ballif BC, Shaffer LG, Eichler EE (2011) A copy number variation morbidity map of developmental delay. Nat Genet 43:838\u2013846","journal-title":"Nat Genet"},{"key":"506_CR9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/path.2643","volume":"220","author":"AJ Copp","year":"2010","unstructured":"Copp AJ, Greene ND (2010) Genetics and development of neural tube defects. J Pathol 220:217\u2013230","journal-title":"J Pathol"},{"key":"506_CR10","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nature08979","volume":"464","author":"N Craddock","year":"2010","unstructured":"Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, Robson S, Vukcevic D, Barnes C, Conrad DF, Giannoulatou E, Holmes C, Marchini JL, Stirrups K, Tobin MD, Wain LV, Yau C, Aerts J, Ahmad T, Andrews TD, Arbury H, Attwood A, Auton A, Ball SG, Balmforth AJ, Barrett JC, Barroso I, Barton A, Bennett AJ, Bhaskar S, Blaszczyk K, Bowes J, Brand OJ, Braund PS, Bredin F, Breen G, Brown MJ, Bruce IN, Bull J, Burren OS, Burton J, Byrnes J, Caesar S, Clee CM, Coffey AJ, Connell JM, Cooper JD, Dominiczak AF, Downes K, Drummond HE, Dudakia D, Dunham A, Ebbs B, Eccles D, Edkins S, Edwards C, Elliot A, Emery P, Evans DM, Evans G, Eyre S, Farmer A, Ferrier IN, Feuk L, Fitzgerald T, Flynn E, Forbes A, Forty L, Franklyn JA, Freathy RM, Gibbs P, Gilbert P, Gokumen O, Gordon-Smith K, Gray E, Green E, Groves CJ, Grozeva D, Gwilliam R, Hall A, Hammond N, Hardy M, Harrison P, Hassanali N, Hebaishi H, Hines S, Hinks A, Hitman GA, Hocking L, Howard E, Howard P, Howson JM, Hughes D, Hunt S, Isaacs JD, Jain M, Jewell DP, Johnson T, Jolley JD, Jones IR, Jones LA, Kirov G, Langford CF, Lango-Allen H, Lathrop GM, Lee J, Lee KL, Lees C, Lewis K, Lindgren CM, Maisuria-Armer M, Maller J, Mansfield J, Martin P, Massey DC, McArdle WL, McGuffin P, McLay KE, Mentzer A, Mimmack ML, Morgan AE, Morris AP, Mowat C, Myers S, Newman W, Nimmo ER, O\u2019Donovan MC, Onipinla A, Onyiah I, Ovington NR, Owen MJ, Palin K, Parnell K, Pernet D, Perry JR, Phillips A, Pinto D, Prescott NJ, Prokopenko I, Quail MA, Rafelt S, Rayner NW, Redon R, Reid DM, Renwick Ring SM, Robertson N, Russell E, St Clair D, Sambrook JG, Sanderson JD, Schuilenburg H, Scott CE, Scott R, Seal S, Shaw-Hawkins S, Shields BM, Simmonds MJ, Smyth DJ, Somaskantharajah E, Spanova K, Steer S, Stephens J, Stevens HE, Stone MA, Su Z, Symmons DP, Thompson JR, Thomson W, Travers ME, Turnbull C, Valsesia A, Walker M, Walker NM, Wallace C, Warren-Perry M, Watkins NA, Webster J, Weedon MN, Wilson AG, Woodburn M, Wordsworth BP, Young AH, Zeggini E, Carter NP, Frayling TM, Lee C, McVean G, Munroe PB, Palotie A, Sawcer SJ, Scherer SW, Strachan DP, Tyler-Smith C, Brown MA, Burton PR, Caulfield MJ, Compston A, Farrall M, Gough SC, Hall AS, Hattersley AT, Hill AV, Mathew CG, Pembrey M, Satsangi J, Stratton MR, Worthington J, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand W, Parkes M, Rahman N, Todd JA, Samani NJ, Donnelly P (2010) Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 464:713\u2013720","journal-title":"Nature"},{"key":"506_CR11","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1073\/pnas.0630494100","volume":"100","author":"C Ding","year":"2003","unstructured":"Ding C, Cantor CR (2003) A high-throughput gene expression analysis technique using competitive PCR and matrix-assisted laser desorption ionization time-of-flight MS. Proc Natl Acad Sci USA 100:3059\u20133064","journal-title":"Proc Natl Acad Sci USA"},{"key":"506_CR12","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1002\/ajmg.a.35552","volume":"158A","author":"AJ Etheredge","year":"2012","unstructured":"Etheredge AJ, Finnell RH, Carmichael SL, Lammer EJ, Zhu H, Mitchell LE, Shaw GM (2012) Maternal and infant gene-folate interactions and the risk of neural tube defects. Am J Med Genet A 158A:2439\u20132446","journal-title":"Am J Med Genet A"},{"key":"506_CR13","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1177\/1933719111433886","volume":"19","author":"Y Gao","year":"2012","unstructured":"Gao Y, Chen X, Shangguan S, Bao Y, Lu X, Zou J, Guo J, Dai Y, Zhang T (2012) Association study of PARD3 gene polymorphisms with neural tube defects in a Chinese Han population. Reprod Sci 19:764\u2013771","journal-title":"Reprod Sci"},{"key":"506_CR14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jbiotec.2013.04.006","volume":"166","author":"Y Gao","year":"2013","unstructured":"Gao Y, Chen X, Wang J, Shangguan S, Dai Y, Zhang T, Liu J (2013) A novel approach for copy number variation analysis by combining multiplex PCR with matrix-assisted laser desorption ionization time-of-flight mass spectrometry. J Biotechnol 166:6\u201311","journal-title":"J Biotechnol"},{"key":"506_CR15","doi-asserted-by":"crossref","first-page":"e1002334","DOI":"10.1371\/journal.pgen.1002334","volume":"7","author":"S Girirajan","year":"2011","unstructured":"Girirajan S, Brkanac Z, Coe BP, Baker C, Vives L, Vu TH, Shafer N, Bernier R, Ferrero GB, Silengo M, Warren ST, Moreno CS, Fichera M, Romano C, Raskind WH, Eichler EE (2011) Relative burden of large CNVs on a range of neurodevelopmental phenotypes. PLoS Genet 7:e1002334","journal-title":"PLoS Genet"},{"key":"506_CR16","doi-asserted-by":"crossref","first-page":"R113","DOI":"10.1093\/hmg\/ddp347","volume":"18","author":"ND Greene","year":"2009","unstructured":"Greene ND, Stanier P, Copp AJ (2009) Genetics of human neural tube defects. Hum Mol Genet 18:R113\u2013R129","journal-title":"Hum Mol Genet"},{"key":"506_CR17","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/bdra.20397","volume":"79","author":"X Gu","year":"2007","unstructured":"Gu X, Lin L, Zheng X, Zhang T, Song X, Wang J, Li X, Li P, Chen G, Wu J, Wu L, Liu J (2007) High prevalence of NTDs in Shanxi Province: a combined epidemiological approach. Birth Defects Res Part A 79:702\u2013707","journal-title":"Birth Defects Res Part A"},{"key":"506_CR18","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ejmg.2007.01.004","volume":"50","author":"P Gustavsson","year":"2007","unstructured":"Gustavsson P, Schoumans J, Staaf J, Borg A, Nordenskjold M, Anneren G (2007) Duplication 16q12.1-q22.1 characterized by array CGH in a girl with spina bifida. Eur J Med Genet 50:237\u2013241","journal-title":"Eur J Med Genet"},{"key":"506_CR19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ydbio.2010.01.034","volume":"341","author":"E Hong","year":"2010","unstructured":"Hong E, Jayachandran P, Brewster R (2010) The polarity protein Pard3 is required for centrosome positioning during neurulation. Dev Biol 341:335\u2013345","journal-title":"Dev Biol"},{"key":"506_CR20","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/ng1416","volume":"36","author":"AJ Iafrate","year":"2004","unstructured":"Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C (2004) Detection of large-scale variation in the human genome. Nat Genet 36:949\u2013951","journal-title":"Nat Genet"},{"key":"506_CR21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ygeno.2008.08.012","volume":"93","author":"I Ionita-Laza","year":"2009","unstructured":"Ionita-Laza I, Rogers AJ, Lange C, Raby BA, Lee C (2009) Genetic association analysis of copy-number variation (CNV) in human disease pathogenesis. Genomics 93:22\u201326","journal-title":"Genomics"},{"key":"506_CR22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/(SICI)1096-8628(19980526)77:4<317::AID-AJMG13>3.0.CO;2-L","volume":"77","author":"D Kennedy","year":"1998","unstructured":"Kennedy D, Chitayat D, Winsor EJ, Silver M, Toi A (1998) Prenatally diagnosed neural tube defects: ultrasound, chromosome, and autopsy or postnatal findings in 212 cases. Am J Med Genet 77:317\u2013321","journal-title":"Am J Med Genet"},{"key":"506_CR23","doi-asserted-by":"crossref","first-page":"E706","DOI":"10.1002\/humu.21026","volume":"30","author":"Z Kibar","year":"2009","unstructured":"Kibar Z, Bosoi CM, Kooistra M, Salem S, Finnell RH, De Marco P, Merello E, Bassuk AG, Capra V, Gros P (2009) Novel mutations in VANGL1 in neural tube defects. Hum Mutat 30:E706\u2013E715","journal-title":"Hum Mutat"},{"key":"506_CR24","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1399-0004.2010.01530_1.x","volume":"78","author":"RA Kumar","year":"2010","unstructured":"Kumar RA (2010) Two-hit wonder: a novel genetic model to explain variable expressivity in severe pediareic phenotypes. Clin Genet 78:517\u2013519","journal-title":"Clin Genet"},{"key":"506_CR25","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1056\/NEJMc0910820","volume":"362","author":"YP Lei","year":"2010","unstructured":"Lei YP, Zhang T, Li H, Wu BL, Jin L, Wang HY (2010) VANGL2 mutations in human cranial neural-tube defects. N Engl J Med 362:2232\u20132235","journal-title":"N Engl J Med"},{"key":"506_CR26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/jmedgenet-2015-103027","volume":"52","author":"P Lemay","year":"2015","unstructured":"Lemay P, Guyot MC, Tremblay E, Dionne-Laporte A, Spiegelman D, Henrion E, Diallo O, De Marco P, Merello E, Massicotte C, Desilets V, Michaud JL, Rouleau GA, Capra V, Kibar Z (2015) Loss-of-function de novo mutations play an important role in severe human neural tube defects. J Med Genet 52:493\u2013497","journal-title":"J Med Genet"},{"key":"506_CR27","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1101\/gr.093856.109","volume":"19","author":"Z Liu","year":"2009","unstructured":"Liu Z, Obenauf AC, Speicher MR, Kopan R (2009) Rapid identification of homologous recombinants and determination of gene copy number with reference\/query pyrosequencing (RQPS). Genome Res 19:2081\u20132089","journal-title":"Genome Res"},{"key":"506_CR28","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.gene.2012.11.070","volume":"515","author":"S Ouyang","year":"2013","unstructured":"Ouyang S, Li Y, Liu Z, Chang H, Wu J (2013) Association between MTR A2756G and MTRR A66G polymorphisms and maternal risk for neural tube defects: a meta-analysis. Gene 515:308\u2013312","journal-title":"Gene"},{"key":"506_CR29","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1158\/0008-5472.CAN-09-3458","volume":"70","author":"SM Rothenberg","year":"2010","unstructured":"Rothenberg SM, Mohapatra G, Rivera MN, Winokur D, Greninger P, Nitta M, Sadow PM, Sooriyakumar G, Brannigan BW, Ulman MJ, Perera RM, Wang R, Tam A, Ma XJ, Erlander M, Sgroi DC, Rocco JW, Lingen MW, Cohen EE, Louis DN, Settleman J, Haber DA (2010) A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res 70:2158\u20132164","journal-title":"Cancer Res"},{"key":"506_CR30","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.1136678","volume":"315","author":"BE Stranger","year":"2007","unstructured":"Stranger BE, Forrest MS, Dunning M, Ingle CE, Beazley C, Thorne N, Redon R, Bird CP, de Grassi A, Lee C, Tyler-Smith C, Carter N, Scherer SW, Tavare S, Deloukas P, Hurles ME, Dermitzakis ET (2007) Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science 315:848\u2013853","journal-title":"Science"},{"key":"506_CR31","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nature05722","volume":"446","author":"M Tawk","year":"2007","unstructured":"Tawk M, Araya C, Lyons DA, Reugels AM, Girdler GC, Bayley PR, Hyde DR, Tada M, Clarke JD (2007) A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature 446:797\u2013800","journal-title":"Nature"},{"key":"506_CR32","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1073\/pnas.0712126105","volume":"105","author":"E Torban","year":"2008","unstructured":"Torban E, Patenaude AM, Leclerc S, Rakowiecki S, Gauthier S, Andelfinger G, Epstein DJ, Gros P (2008) Genetic interaction between members of the Vangl family causes neural tube defects in mice. Proc Natl Acad Sci USA 105:3449\u20133454","journal-title":"Proc Natl Acad Sci USA"},{"key":"506_CR33","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrg3241","volume":"13","author":"JA Veltman","year":"2012","unstructured":"Veltman JA, Brunner HG (2012) De novo mutations in human genetic disease. Nat Rev Genet 13:565\u2013575","journal-title":"Nat Rev Genet"},{"key":"506_CR34","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1177\/1933719110393026","volume":"18","author":"J Wang","year":"2011","unstructured":"Wang J, Liu C, Zhao H, Wang F, Guo J, Xie H, Lu X, Bao Y, Pei L, Niu B, Zhong R, Zheng X, Zhang T (2011) Association between a 45-bp 3\u2032untranslated insertion\/deletion polymorphism in exon 8 of UCP2 gene and neural tube defects in a high-risk area of China. Reprod Sci 18:556\u2013560","journal-title":"Reprod Sci"},{"key":"506_CR35","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/ajmg.a.33230","volume":"152A","author":"S Wen","year":"2010","unstructured":"Wen S, Zhu H, Lu W, Mitchell LE, Shaw GM, Lammer EJ, Finnell RH (2010) Planar cell polarity pathway genes and risk for spina bifida. Am J Med Genet A 152A:299\u2013304","journal-title":"Am J Med Genet A"},{"key":"506_CR36","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1038\/onc.2009.148","volume":"28","author":"K Zen","year":"2009","unstructured":"Zen K, Yasui K, Gen Y, Dohi O, Wakabayashi N, Mitsufuji S, Itoh Y, Zen Y, Nakanuma Y, Taniwaki M, Okanoue T, Yoshikawa T (2009) Defective expression of polarity protein PAR-3 gene (PARD3) in esophageal squamous cell carcinoma. Oncogene 28:2910\u20132918","journal-title":"Oncogene"},{"key":"506_CR37","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1017\/S1368980008002735","volume":"12","author":"T Zhang","year":"2009","unstructured":"Zhang T, Xin R, Gu X, Wang F, Pei L, Lin L, Chen G, Wu J, Zheng X (2009) Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China. Public Health Nutr 12:680\u2013686","journal-title":"Public Health Nutr"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10571-017-0506-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-017-0506-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-017-0506-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T08:18:09Z","timestamp":1602317889000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10571-017-0506-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,16]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["506"],"URL":"https:\/\/doi.org\/10.1007\/s10571-017-0506-0","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"type":"print","value":"0272-4340"},{"type":"electronic","value":"1573-6830"}],"subject":[],"published":{"date-parts":[[2017,6,16]]}}}