{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:22:21Z","timestamp":1791361341252,"version":"4.3.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s10571-018-0602-9","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T16:17:02Z","timestamp":1531239422000},"page":"1369-1382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Genome-Wide Sequencing Reveals Small Nucleolar RNAs Downregulated in Cerebral Cavernous Malformations"],"prefix":"10.1007","volume":"38","author":[{"given":"Souvik","family":"Kar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran Kumar","family":"Bali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpita","family":"Baisantry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Geffers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Samii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Bertalanffy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"issue":"11","key":"602_CR1","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1002\/emmm.201302797","volume":"5","author":"KK Bali","year":"2013","unstructured":"Bali KK, Selvaraj D, Satagopam VP, Lu J, Schneider R, Kuner R (2013)Genome-wide identification and functional analyses of microRNA signatures associated with cancer pain\u201d. EMBO Mol Med 5(11):1740\u20131758","journal-title":"EMBO Mol Med"},{"key":"602_CR2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1744-8069-10-22","volume":"10","author":"KK Bali","year":"2014","unstructured":"Bali KK, Hackenberg M, Lubin A, Kuner R, Devor M (2014) Sources of individual variability: miRNAs that predispose to neuropathic pain identified using genome-wide sequencing. Mol Pain 10:22","journal-title":"Mol Pain"},{"key":"602_CR3","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3389\/fsurg.2016.00060","volume":"3","author":"JF Baranoski","year":"2016","unstructured":"Baranoski JF, Kalani MY, Przybylowski CJ, Zabramski JM (2016) Cerebral cavernous malformations: review of the genetic and protein-protein interactions resulting in disease pathogenesis. Front Surg 3:60","journal-title":"Front Surg"},{"issue":"1\u20132","key":"602_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s101430100179","volume":"25","author":"H Bertalanffy","year":"2002","unstructured":"Bertalanffy H, Benes L, Miyazawa T, Alberti O, Siegel AM, Sure U (2002) Cerebral cavernomas in the adult. Review of the literature and analysis of 72 surgically treated patients. Neurosurg Rev 25(1\u20132):1\u201353; discussion 54\u201355","journal-title":"Neurosurg Rev"},{"issue":"14","key":"602_CR5","doi-asserted-by":"publisher","first-page":"6800","DOI":"10.1093\/nar\/gks321","volume":"40","author":"ML Bortolin-Cavaille","year":"2012","unstructured":"Bortolin-Cavaille ML, Cavaille J (2012) \u201cThe SNORD115 (H\/MBII-52) and SNORD116 (H\/MBII-85) gene clusters at the imprinted Prader-Willi locus generate canonical box C\/D snoRNAs\u201d. Nucleic Acids Res 40(14):6800\u20136807","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"602_CR6","doi-asserted-by":"publisher","first-page":"E6","DOI":"10.3171\/2010.5.FOCUS10120","volume":"29","author":"PG Campbell","year":"2010","unstructured":"Campbell PG, Jabbour P, Yadla S, Awad IA (2010) Emerging clinical imaging techniques for cerebral cavernous malformations: a systematic review. Neurosurg Focus 29(3):E6","journal-title":"Neurosurg Focus"},{"issue":"13","key":"602_CR7","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1093\/bioinformatics\/btv113","volume":"31","author":"V Capece","year":"2015","unstructured":"Capece V, Garcia Vizcaino JC, Vidal R, Rahman RU, Pena Centeno T, Shomroni O, Suberviola I, Fischer A, Bonn S (2015) Oasis: online analysis of small RNA deep sequencing data. Bioinformatics 31(13):2205\u20132207","journal-title":"Bioinformatics"},{"issue":"26","key":"602_CR8","doi-asserted-by":"publisher","first-page":"14311","DOI":"10.1073\/pnas.250426397","volume":"97","author":"J Cavaille","year":"2000","unstructured":"Cavaille J, Buiting K, Kiefmann M, Lalande M, Brannan CI, Horsthemke B, Bachellerie JP, Brosius J, Huttenhofer A (2000) Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization. Proc Natl Acad Sci USA 97(26):14311\u201314316","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"602_CR9","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/S0006-291X(02)02623-2","volume":"299","author":"LS Chang","year":"2002","unstructured":"Chang LS, Lin SY, Lieu AS, Wu TL (2002) Differential expression of human 5S snoRNA genes. Biochem Biophys Res Commun 299(2):196\u2013200","journal-title":"Biochem Biophys Res Commun"},{"key":"602_CR10","doi-asserted-by":"publisher","first-page":"8588","DOI":"10.1038\/srep08588","volume":"5","author":"L Chen","year":"2015","unstructured":"Chen L, Han L, Wei J, Zhang K, Shi Z, Duan R, Li S, Zhou X, Pu P, Zhang J, Kang C (2015) SNORD76, a box C\/D snoRNA, acts as a tumor suppressor in glioblastoma. Sci Rep 5:8588","journal-title":"Sci Rep"},{"issue":"3","key":"602_CR11","first-page":"211","volume":"59","author":"H Choquet","year":"2015","unstructured":"Choquet H, Pawlikowska L, Lawton MT, Kim H (2015) Genetics of cerebral cavernous malformations: current status and future prospects. J Neurosurg Sci 59(3):211\u2013220","journal-title":"J Neurosurg Sci"},{"issue":"1","key":"602_CR12","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR (2013) STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29(1):15\u201321","journal-title":"Bioinformatics"},{"issue":"7","key":"602_CR13","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1093\/hmg\/ddm375","volume":"17","author":"XY Dong","year":"2008","unstructured":"Dong XY, Rodriguez C, Guo P, Sun X, Talbot JT, Zhou W, Petros J, Li Q, Vessella RL, Kibel AS, Stevens VL, Calle EE, Dong JT (2008) SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer. Hum Mol Genet 17(7):1031\u20131042","journal-title":"Hum Mol Genet"},{"issue":"Suppl 3","key":"602_CR14","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1186\/1471-2164-11-S3-S16","volume":"11","author":"H Dong","year":"2010","unstructured":"Dong H, Siu H, Luo L, Fang X, Jin L, Xiong M (2010) Investigation gene and microRNA expression in glioblastoma. BMC Genom 11(Suppl 3):S16","journal-title":"BMC Genom"},{"issue":"Pt 4","key":"602_CR15","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1242\/jcs.138388","volume":"127","author":"KM Draheim","year":"2014","unstructured":"Draheim KM, Fisher OS, Boggon TJ, Calderwood DA (2014) Cerebral cavernous malformation proteins at a glance. J Cell Sci 127(Pt 4):701\u2013707","journal-title":"J Cell Sci"},{"issue":"3","key":"602_CR16","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0955-0674(02)00334-4","volume":"14","author":"W Filipowicz","year":"2002","unstructured":"Filipowicz W, Pogacic V (2002) Biogenesis of small nucleolar ribonucleoproteins. Curr Opin Cell Biol 14(3):319\u2013327","journal-title":"Curr Opin Cell Biol"},{"issue":"6","key":"602_CR17","doi-asserted-by":"publisher","first-page":"E623","DOI":"10.1002\/ijc.29169","volume":"136","author":"L Gao","year":"2015","unstructured":"Gao L, Ma J, Mannoor K, Guarnera MA, Shetty A, Zhan M, Xing L, Stass SA, Jiang F (2015) Genome-wide small nucleolar RNA expression analysis of lung cancer by next-generation deep sequencing. Int J Cancer 136(6):E623\u2013E629","journal-title":"Int J Cancer"},{"issue":"4","key":"602_CR18","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1227\/01.NEU.0000114512.59624.A5","volume":"54","author":"O Guzeloglu-Kayisli","year":"2004","unstructured":"Guzeloglu-Kayisli O, Amankulor NM, Voorhees J, Luleci G, Lifton RP, Gunel M (2004) KRIT1\/cerebral cavernous malformation 1 protein localizes to vascular endothelium, astrocytes, and pyramidal cells of the adult human cerebral cortex. Neurosurgery 54(4):943\u2013949; discussion 949","journal-title":"Neurosurgery"},{"issue":"3","key":"602_CR19","first-page":"170","volume":"3","author":"L Ho","year":"2014","unstructured":"Ho L, Lange G, Zhao W, Wang J, Rooney R, Patel DH, Fobler MM, Helmer DA, Elder G, Shaughness MC, Ahlers ST, Russo SJ, Pasinetti GM (2014) Select small nucleolar RNAs in blood components as novel biomarkers for improved identification of comorbid traumatic brain injury and post-traumatic stress disorder in veterans of the conflicts in Afghanistan and Iraq. Am J Neurodegener Dis 3(3):170\u2013181","journal-title":"Am J Neurodegener Dis"},{"key":"602_CR20","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1515\/tnsci-2017-0010","volume":"8","author":"F Huang","year":"2017","unstructured":"Huang F, Yi J, Zhou T, Gong X, Jiang H, Yao X (2017) Toward understanding non-coding RNA roles in intracranial aneurysms and subarachnoid hemorrhage. Transl Neurosci 8:54\u201364","journal-title":"Transl Neurosci"},{"issue":"10","key":"602_CR21","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1038\/ng.3661","volume":"48","author":"EM Jenkinson","year":"2016","unstructured":"Jenkinson EM, Rodero MP, Kasher PR, Uggenti C, Oojageer A, Goosey LC, Rose Y, Kershaw CJ, Urquhart JE, Williams SG, Bhaskar SS, O\u2019Sullivan J, Baerlocher GM, Haubitz M, Aubert G, Baranano KW, Barnicoat AJ, Battini R, Berger A, Blair EM, Brunstrom-Hernandez JE, Buckard JA, Cassiman DM, Caumes R, Cordelli DM, De Waele LM, Fay AJ, Ferreira P, Fletcher NA, Fryer AE, Goel H, Hemingway CA, Henneke M, Hughes I, Jefferson RJ, Kumar R, Lagae L, Landrieu PG, Lourenco CM, Malpas TJ, Mehta SG, Metz I, Naidu S, Ounap K, Panzer A, Prabhakar P, Quaghebeur G, Schiffmann R, Sherr EH, Sinnathuray KR, Soh C, Stewart HS, Stone J, Van Esch H, Van Mol CE, Vanderver A, Wakeling EL, Whitney A, Pavitt GD, Griffiths-Jones S, Rice GI, Revy P, Crow YJ, van der Knaap MS, Livingston JH, O\u2019Keefe RT (2016) Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts. Nat Genet 48(10):1185\u20131192","journal-title":"Nat Genet"},{"issue":"10","key":"602_CR22","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1002\/ijc.29610","volume":"137","author":"P Jha","year":"2015","unstructured":"Jha P, Agrawal R, Pathak P, Kumar A, Purkait S, Mallik S, Suri V, Chand Sharma M, Gupta D, Suri A, Sharma BS, Julka PK, Kulshreshtha R, Sarkar C (2015) Genome-wide small noncoding RNA profiling of pediatric high-grade gliomas reveals deregulation of several miRNAs, identifies downregulation of snoRNA cluster HBII-52 and delineates H3F3A and TP53 mutant-specific miRNAs and snoRNAs. Int J Cancer 137(10):2343\u20132353","journal-title":"Int J Cancer"},{"issue":"11","key":"602_CR23","doi-asserted-by":"publisher","first-page":"5068","DOI":"10.1093\/nar\/gkw386","volume":"44","author":"H Jorjani","year":"2016","unstructured":"Jorjani H, Kehr S, Jedlinski DJ, Gumienny R, Hertel J, Stadler PF, Zavolan M, Gruber AR (2016) An updated human snoRNAome. Nucleic Acids Res 44(11):5068\u20135082","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"602_CR24","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/s12031-017-0880-6","volume":"61","author":"S Kar","year":"2017","unstructured":"Kar S, Bali KK, Baisantry A, Geffers R, Samii A, Bertalanffy H (2017) Genome-wide sequencing reveals microRNAs downregulated in cerebral cavernous malformations. J Mol Neurosci 61(2):178\u2013188","journal-title":"J Mol Neurosci"},{"issue":"5758","key":"602_CR25","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1126\/science.1118265","volume":"311","author":"S Kishore","year":"2006","unstructured":"Kishore S, Stamm S (2006a) \u201cThe snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2. Science 311(5758):230\u2013232","journal-title":"Science"},{"key":"602_CR26","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1101\/sqb.2006.71.024","volume":"71","author":"S Kishore","year":"2006","unstructured":"Kishore S, Stamm S (2006b) Regulation of alternative splicing by snoRNAs. Cold Spring Harb Symp Quant Biol 71:329\u2013334","journal-title":"Cold Spring Harb Symp Quant Biol"},{"issue":"7","key":"602_CR27","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1093\/hmg\/ddp585","volume":"19","author":"S Kishore","year":"2010","unstructured":"Kishore S, Khanna A, Zhang Z, Hui J, Balwierz PJ, Stefan M, Beach C, Nicholls RD, Zavolan M, Stamm S (2010) The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing. Hum Mol Genet 19(7):1153\u20131164","journal-title":"Hum Mol Genet"},{"issue":"9","key":"602_CR28","doi-asserted-by":"publisher","first-page":"e0162622","DOI":"10.1371\/journal.pone.0162622","volume":"11","author":"P Krishnan","year":"2016","unstructured":"Krishnan P, Ghosh S, Wang B, Heyns M, Graham K, Mackey JR, Kovalchuk O, Damaraju S (2016) Profiling of small nucleolar RNAs by next generation sequencing: potential new players for breast cancer prognosis. PLoS ONE 11(9):e0162622","journal-title":"PLoS ONE"},{"key":"602_CR29","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/1476-4598-9-198","volume":"9","author":"J Liao","year":"2010","unstructured":"Liao J, Yu L, Mei Y, Guarnera M, Shen J, Li R, Liu Z, Jiang F (2010) Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer. Mol Cancer 9:198","journal-title":"Mol Cancer"},{"issue":"7","key":"602_CR30","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao Y, Smyth GK, Shi W (2014) featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30(7):923\u2013930","journal-title":"Bioinformatics"},{"issue":"12","key":"602_CR31","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15(12):550","journal-title":"Genome Biol"},{"issue":"4","key":"602_CR32","doi-asserted-by":"publisher","first-page":"601","DOI":"10.18388\/abp.2016_1330","volume":"63","author":"AM Mleczko","year":"2016","unstructured":"Mleczko AM, Bakowska-Zywicka K (2016) When small RNAs become smaller: emerging functions of snoRNAs and their derivatives. Acta Biochim Pol 63(4):601\u2013607","journal-title":"Acta Biochim Pol"},{"issue":"1","key":"602_CR33","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/genes1010070","volume":"1","author":"S Motameny","year":"2010","unstructured":"Motameny S, Wolters S, Nurnberg P, Schumacher B (2010) Next generation sequencing of miRNAs\u2014strategies, resources and methods. Genes (Basel) 1(1):70\u201384","journal-title":"Genes (Basel)"},{"issue":"1","key":"602_CR34","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s10585-010-9355-7","volume":"28","author":"BS Nielsen","year":"2011","unstructured":"Nielsen BS, Jorgensen S, Fog JU, Sokilde R, Christensen IJ, Hansen U, Brunner N, Baker A, Moller S, Nielsen HJ (2011) High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients. Clin Exp Metastasis 28(1):27\u201338","journal-title":"Clin Exp Metastasis"},{"issue":"1","key":"602_CR35","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1136\/gutjnl-2015-309359","volume":"66","author":"Y Okugawa","year":"2017","unstructured":"Okugawa Y, Toiyama Y, Toden S, Mitoma H, Nagasaka T, Tanaka K, Inoue Y, Kusunoki M, Boland CR, Goel A (2017) Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer. Gut 66(1):107\u2013117","journal-title":"Gut"},{"issue":"Pt B","key":"602_CR36","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.biocel.2016.09.011","volume":"81","author":"SF Retta","year":"2016","unstructured":"Retta SF, Glading AJ (2016) Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin. Int J Biochem Cell Biol 81(Pt B):254\u2013270","journal-title":"Int J Biochem Cell Biol"},{"issue":"5","key":"602_CR37","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1111\/j.1742-4658.2009.07535.x","volume":"277","author":"F Riant","year":"2010","unstructured":"Riant F, Bergametti F, Ayrignac X, Boulday G, Tournier-Lasserve E (2010) Recent insights into cerebral cavernous malformations: the molecular genetics of CCM. FEBS J 277(5):1070\u20131075","journal-title":"FEBS J"},{"issue":"11","key":"602_CR38","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1016\/j.biochi.2011.05.026","volume":"93","author":"MS Scott","year":"2011","unstructured":"Scott MS, Ono M (2011) From snoRNA to miRNA: dual function regulatory non-coding RNAs. Biochimie 93(11):1987\u20131992","journal-title":"Biochimie"},{"issue":"2","key":"602_CR39","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1161\/01.STR.0000198835.49387.25","volume":"37","author":"A Seker","year":"2006","unstructured":"Seker A, Pricola KL, Guclu B, Ozturk AK, Louvi A, Gunel M (2006) CCM2 expression parallels that of CCM1. Stroke 37(2):518\u2013523","journal-title":"Stroke"},{"issue":"1","key":"602_CR40","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1161\/STROKEAHA.116.015013","volume":"48","author":"R Shenkar","year":"2017","unstructured":"Shenkar R, Shi C, Austin C, Moore T, Lightle R, Cao Y, Zhang L, Wu M, Zeineddine HA, Girard R, McDonald DA, Rorrer A, Gallione C, Pytel P, Liao JK, Marchuk DA, Awad IA (2017) RhoA kinase inhibition with fasudil versus simvastatin in murine models of cerebral cavernous malformations. Stroke 48(1):187\u2013194","journal-title":"Stroke"},{"issue":"4","key":"602_CR41","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1161\/CIRCRESAHA.108.191270","volume":"104","author":"Y Suarez","year":"2009","unstructured":"Suarez Y, Sessa WC (2009) MicroRNAs as novel regulators of angiogenesis. Circ Res 104(4):442\u2013454","journal-title":"Circ Res"},{"issue":"11","key":"602_CR42","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/nsmb.2902","volume":"21","author":"JY Tan","year":"2014","unstructured":"Tan JY, Vance KW, Varela MA, Sirey T, Watson LM, Curtis HJ, Marinello M, Alves S, Steinkraus B, Cooper S, Nesterova T, Brockdorff N, Fulga T, Brice A, Sittler A, Oliver PL, Wood MJ, Ponting CP, Marques AC (2014) Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7. Nat Struct Mol Biol 21(11):955\u2013961","journal-title":"Nat Struct Mol Biol"},{"issue":"7654","key":"602_CR43","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/nature22075","volume":"545","author":"AT Tang","year":"2017","unstructured":"Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Vosa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML (2017) Endothelial TLR4 and the microbiome drive cerebral cavernous malformations. Nature 545(7654):305\u2013310","journal-title":"Nature"},{"issue":"1","key":"602_CR44","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.bbadis.2008.09.017","volume":"1792","author":"J Tazi","year":"2009","unstructured":"Tazi J, Bakkour N, Stamm S (2009) Alternative splicing and disease. Biochim Biophys Acta 1792(1):14\u201326","journal-title":"Biochim Biophys Acta"},{"issue":"19","key":"602_CR45","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.1182\/blood-2012-06-438135","volume":"120","author":"W Valleron","year":"2012","unstructured":"Valleron W, Ysebaert L, Berquet L, Fataccioli V, Quelen C, Martin A, Parrens M, Lamant L, de Leval L, Gisselbrecht C, Gaulard P, Brousset P (2012) Small nucleolar RNA expression profiling identifies potential prognostic markers in peripheral T-cell lymphoma. Blood 120(19):3997\u20134005","journal-title":"Blood"},{"issue":"Pt 11","key":"602_CR46","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1242\/jcs.061713","volume":"123","author":"JC Wolfswinkel van","year":"2010","unstructured":"van Wolfswinkel JC, Ketting RF (2010) The role of small non-coding RNAs in genome stability and chromatin organization. J Cell Sci 123(Pt 11):1825\u20131839","journal-title":"J Cell Sci"},{"issue":"13","key":"602_CR47","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1093\/hmg\/ddy136","volume":"27","author":"M Vijayan","year":"2018","unstructured":"Vijayan M, Kumar S, Yin X, Zafer D, Chanana V, Cengiz P, Reddy PH (2018) Identification of novel circulatory microRNA signatures linked to patients with ischemic stroke. Hum Mol Genet 27(13):2318\u20132329","journal-title":"Hum Mol Genet"},{"key":"602_CR48","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/1476-4598-13-216","volume":"13","author":"G Xu","year":"2014","unstructured":"Xu G, Yang F, Ding CL, Zhao LJ, Ren H, Zhao P, Wang W, Qi ZT (2014) Small nucleolar RNA 113-1 suppresses tumorigenesis in hepatocellular carcinoma. Mol Cancer 13:216","journal-title":"Mol Cancer"},{"issue":"3","key":"602_CR49","doi-asserted-by":"publisher","first-page":"352","DOI":"10.2174\/15701611113119990016","volume":"13","author":"KJ Yin","year":"2015","unstructured":"Yin KJ, Hamblin M, Chen YE (2015) Angiogenesis-regulating microRNAs and Ischemic stroke. Curr Vasc Pharmacol 13(3):352\u2013365","journal-title":"Curr Vasc Pharmacol"},{"issue":"2","key":"602_CR50","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ydbio.2011.12.006","volume":"362","author":"B Yoruk","year":"2012","unstructured":"Yoruk B, Gillers BS, Chi NC, Scott IC (2012) Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease. Dev Biol 362(2):121\u2013131","journal-title":"Dev Biol"},{"issue":"7597","key":"602_CR51","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/nature17178","volume":"532","author":"Z Zhou","year":"2016","unstructured":"Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, Kahn ML (2016) Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2\/4 signalling. Nature 532(7597):122\u2013126","journal-title":"Nature"},{"issue":"6","key":"602_CR52","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1261\/rna.049262.114","volume":"21","author":"AE Zou","year":"2015","unstructured":"Zou AE, Ku J, Honda TK, Yu V, Kuo SZ, Zheng H, Xuan Y, Saad MA, Hinton A, Brumund KT, Lin JH, Wang-Rodriguez J, Ongkeko WM (2015) Transcriptome sequencing uncovers novel long noncoding and small nucleolar RNAs dysregulated in head and neck squamous cell carcinoma. RNA 21(6): 1122\u20131134","journal-title":"RNA"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10571-018-0602-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-018-0602-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-018-0602-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T23:27:35Z","timestamp":1562714855000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10571-018-0602-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,10]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["602"],"URL":"https:\/\/doi.org\/10.1007\/s10571-018-0602-9","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,10]]},"assertion":[{"value":"29 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the responsible committee (institutional and national) and with the 1964 Helsinki declaration and its later amendments. This study was approved by the local ethical committee at the Hannover Medical School (Approval Number 6960).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}