{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:26:52Z","timestamp":1792628812906,"version":"4.5.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T00:00:00Z","timestamp":1578700800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T00:00:00Z","timestamp":1578700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100011447","name":"Science and Technology Department of Henan Province","doi-asserted-by":"crossref","award":["172102310578"],"award-info":[{"award-number":["172102310578"]}],"id":[{"id":"10.13039\/501100011447","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s10571-020-00788-4","type":"journal-article","created":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T16:02:31Z","timestamp":1578758551000},"page":"991-997","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of Escitalopram on Serum GDNF and BDNF Levels and 5-HT Level of Brain Tissue of Obsessive\u2013Compulsive Disorder Rats"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1167-0443","authenticated-orcid":false,"given":"Hui-Rong","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai-Ling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Gang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Pei","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ming","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,11]]},"reference":[{"issue":"12","key":"788_CR1","first-page":"785","volume":"55","author":"A Bagheri","year":"2017","unstructured":"Bagheri A, Talei S, Hassanzadeh N, Mokhtari T, Akbari M, Malek F, Jameie SB, Sadeghi Y, Hassanzadeh G (2017) The neuroprotective effects of flaxseed oil supplementation on functional motor recovery in a model of ischemic brain stroke: upregulation of BDNF and GDNF. Acta Med Iran 55(12):785\u2013792","journal-title":"Acta Med Iran"},{"issue":"5","key":"788_CR2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/YIC.0000000000000037","volume":"29","author":"J Bergman","year":"2014","unstructured":"Bergman J, Pashinian A, Weizman A, Poyurovsky M (2014) The beneficial effect of escitalopram on obsessive-compulsive-related musical hallucinations in elderly patients with hearing impairment: a case series. Int Clin Psychopharmacol 29(5):263\u2013265","journal-title":"Int Clin Psychopharmacol"},{"issue":"8","key":"788_CR3","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1007\/s00787-017-1099-3","volume":"27","author":"R \u00c7olak Sivri","year":"2018","unstructured":"\u00c7olak Sivri R, Bilgi\u00e7 A, K\u0131l\u0131n\u00e7 \u0130 (2018) Cytokine, chemokine and BDNF levels in medication-free pediatric patients with obsessive-compulsive disorder. Eur Child Adolesc Psychiatry 27(8):977\u2013984","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"788_CR4","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.bbr.2013.08.049","volume":"256","author":"W de Wolmarans","year":"2013","unstructured":"de Wolmarans W, Brand L, Stein DJ, Harvey BH (2013) Reappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessive-compulsive disorder (OCD): response to escitalopram treatment and basal serotonin transporter (SERT) density. Behav Brain Res 256:545\u2013553","journal-title":"Behav Brain Res"},{"issue":"2","key":"788_CR5","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0006-8993(89)90243-6","volume":"490","author":"D Eilam","year":"1989","unstructured":"Eilam D, Golani I, Szechtman H (1989) D2-agonist quinpirole induces perseveration of routes and hyperactivity but no perseveration of movements. Brain Res 490(2):255\u2013267","journal-title":"Brain Res"},{"issue":"3","key":"788_CR6","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.psychres.2012.03.034","volume":"199","author":"LF Fontenelle","year":"2012","unstructured":"Fontenelle LF, Barbosa IG, Luna JV, Rocha NP, Silva Miranda A, Teixeira AL (2012) Neurotrophic factors in obsessive-compulsive disorder. Psychiatry Res 199(3):195\u2013200","journal-title":"Psychiatry Res"},{"key":"788_CR7","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.jad.2015.01.014","volume":"175","author":"L Ghio","year":"2015","unstructured":"Ghio L, Gotelli S, Cervetti A, Respino M, Natta W, Marcenaro M, Serafini G, Vaggi M, Amore M, Belvederi Murri M (2015) Duration of untreated depression influences clinical outcomes and disability. J Affect Disord 175:224\u2013228","journal-title":"J Affect Disord"},{"issue":"3","key":"788_CR8","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.psc.2014.06.004","volume":"37","author":"WK Goodman","year":"2014","unstructured":"Goodman WK, Grice DE, Lapidus KA, Coffey BJ (2014) Obsessive-compulsive disorder. Psychiatr Clin North Am 37(3):257\u2013267","journal-title":"Psychiatr Clin North Am"},{"issue":"53","key":"788_CR9","doi-asserted-by":"publisher","first-page":"81","DOI":"10.4103\/pm.pm_90_17","volume":"14","author":"Y Guo","year":"2018","unstructured":"Guo Y, Luo C, Tu G, Li C, Liu Y, Liu W, Lam Yung KK, Mo Z (2018) Rhynchophylline downregulates phosphorylated cAMP response element binding protein, nuclear receptor-related-1, and brain-derived neurotrophic factor expression in the hippocampus of ketamine-induced conditioned place preference rats. Pharmacogn Mag 14(53):81\u201386","journal-title":"Pharmacogn Mag"},{"issue":"1","key":"788_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00213-015-4086-8","volume":"233","author":"EV Ho","year":"2016","unstructured":"Ho EV, Thompson SL, Katzka WR, Sharifi MF, Knowles JA, Dulawa SC (2016) Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation. Psychopharmacology 233(1):57\u201370","journal-title":"Psychopharmacology"},{"issue":"2","key":"788_CR11","doi-asserted-by":"publisher","first-page":"E44","DOI":"10.1176\/appi.neuropsych.13050103","volume":"26","author":"YC Hou","year":"2014","unstructured":"Hou YC, Lai CH (2014) Rapid responses of high-dose combined therapy of escitalopram and aripiprazole in a case of severe obsessive compulsive disorder with delusion. J Neuropsychiatry Clin Neurosci 26(2):E44\u2013E45","journal-title":"J Neuropsychiatry Clin Neurosci"},{"issue":"1","key":"788_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/hup.2642","volume":"33","author":"J Lee","year":"2018","unstructured":"Lee J, Kim BH, Kim E, Howes OD, Cho KIK, Yoon YB (2018) Kwon JS (2018) Higher serotonin transporter availability in early-onset obsessive-compulsive disorder patients undergoing escitalopram treatment: A [11 C] DASB PET study. Hum Psychopharmacol 33(1):1\u20132. https:\/\/doi.org\/10.1002\/hup.2642","journal-title":"Hum Psychopharmacol"},{"issue":"1","key":"788_CR13","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.bbr.2011.09.029","volume":"226","author":"C Lochner","year":"2012","unstructured":"Lochner C, Simmons C, Kidd M, Chamberlain SR, Fineberg NA, van Honk J, Ipser J, Stein DJ (2012) Differential effects of escitalopram challenge on disgust processing in obsessive-compulsive disorder. Behav Brain Res 226(1):274\u2013280","journal-title":"Behav Brain Res"},{"issue":"6","key":"788_CR14","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1177\/0271678X18766772","volume":"38","author":"C Marie","year":"2018","unstructured":"Marie C, Pedard M, Quiri\u00e9 A, Tessier A, Garnier P, Totoson P, Demougeot C (2018) Brain-derived neurotrophic factor secreted by the cerebral endothelium: a new actor of brainfunction? J Cereb Blood Flow Metab. 38(6):935\u2013949","journal-title":"J Cereb Blood Flow Metab."},{"issue":"4","key":"788_CR15","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.prp.2018.02.013","volume":"214","author":"A Mori","year":"2018","unstructured":"Mori A, Nishioka Y, Yamada M, Nishibata Y, Masuda S, Tomaru U, Honma N, Moriyama T, Ishizu A (2018) Brain-derived neurotrophic factor induces angiogenin secretion and nuclear translocation in human umbilical vein endothelial cells. Pathol Res Pract 214(4):521\u2013526","journal-title":"Pathol Res Pract"},{"issue":"8","key":"788_CR16","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1111\/pcn.12195","volume":"68","author":"T Nakao","year":"2014","unstructured":"Nakao T, Okada K, Kanba S (2014) Neurobiological model of obsessive-compulsive disorder: evidence from recent neuropsychological and neuroimaging findings. Psychiatry Clin Neurosci 68(8):587\u2013605","journal-title":"Psychiatry Clin Neurosci"},{"key":"788_CR17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cca.2018.06.017","volume":"485","author":"F Pedrotti Moreira","year":"2018","unstructured":"Pedrotti Moreira F, Wiener CD, Jansen K, Portela LV, Lara DR, Souza LDM, da Silva RA, Oses JP (2018) Serum GDNF levels and anxiety disorders in a population-based study of young adults. Clin Chim Acta 485:21\u201325","journal-title":"Clin Chim Acta"},{"issue":"10","key":"788_CR18","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1517\/14656566.2014.914493","volume":"15","author":"M Pizarro","year":"2014","unstructured":"Pizarro M, Fontenelle LF, Paravidino DC, Y\u00fccel M, Miguel EC, de Menezes GB (2014) An updated review of antidepressants with marked serotonergic effects in obsessive-compulsive disorder. Expert Opin Pharmacother 15(10):1391\u20131401","journal-title":"Expert Opin Pharmacother"},{"issue":"4","key":"788_CR19","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1093\/jnen\/nly009","volume":"77","author":"C Ruven","year":"2018","unstructured":"Ruven C, Badea SR, Wong WM, Wu W (2018) Combination treatment with exogenous GDNF and fetal spinal cord cells results in better motoneuron survival and functional recovery after avulsion injury with delayed root reimplantation. J Neuropathol Exp Neurol 77(4):325\u2013343","journal-title":"J Neuropathol Exp Neurol"},{"issue":"2","key":"788_CR20","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1097\/YIC.0b013e32835bd24e","volume":"28","author":"R Stryjer","year":"2013","unstructured":"Stryjer R, Dambinsky Y, Timinsky I, Green T, Kotler M, Weizman A, Spivak B (2013) Escitalopram in the treatment of patients with schizophrenia and obsessive-compulsive disorder: an open-label, prospective study. Int Clin Psychopharmacol 28(2):96\u201398","journal-title":"Int Clin Psychopharmacol"},{"issue":"7","key":"788_CR21","first-page":"55","volume":"29","author":"S Suliman","year":"2013","unstructured":"Suliman S, Hemmings SM, Seedat S (2013) Brain-derived neurotrophic factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis. Front Integr Neurosci 29(7):55","journal-title":"Front Integr Neurosci"},{"issue":"6","key":"788_CR22","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1037\/0735-7044.112.6.1475","volume":"112","author":"H Szechtman","year":"1998","unstructured":"Szechtman H, Sulis W, Eilam D (1998) Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD). Behav Neurosci 112(6):1475\u20131485","journal-title":"Behav Neurosci"},{"issue":"2","key":"788_CR23","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.bbrc.2018.01.020","volume":"496","author":"X Wang","year":"2018","unstructured":"Wang X, Min S, Xie F, Yang J, Li L, Chen J (2018) Glial cell-derived neurotrophic factor alleviates sepsis-induced neuromuscular dysfunction by decreasing the expression of \u03b3- and \u03b17-nicotinic acetylcholine receptors in an experimental rat model of neuromyopathy. Biochem Biophys Res Commun 496(2):260\u2013266","journal-title":"Biochem Biophys Res Commun"},{"issue":"18","key":"788_CR24","first-page":"22","volume":"38","author":"XP Yan","year":"2017","unstructured":"Yan XP, Rao Y (2017) Comparison of the efficacy of escitalopram and paroxetine in the treatment of obsessive-compulsive disorder. Shanghai Med Pharmaceutical J 38(18):22\u201324","journal-title":"Shanghai Med Pharm J"},{"issue":"17","key":"788_CR25","first-page":"126","volume":"19","author":"LL Zhao","year":"2016","unstructured":"Zhao LL (2016) Analysis of the efficacy and adverse reactions of escitalopram and paroxetine in the treatment of obsessive-compulsive disorder. Chin J Pract Nervous Dis 19(17):126\u2013128","journal-title":"Chin J Pract Nervous Dis"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-020-00788-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10571-020-00788-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-020-00788-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T02:06:41Z","timestamp":1610244401000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10571-020-00788-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,11]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["788"],"URL":"https:\/\/doi.org\/10.1007\/s10571-020-00788-4","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,11]]},"assertion":[{"value":"20 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}