{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:00:07Z","timestamp":1789610407589,"version":"build-2803163510"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s10571-020-00930-2","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T07:04:06Z","timestamp":1595833446000},"page":"1625-1634","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Valproic Acid Sensitizes Glioma Cells to Luteolin Through Induction of Apoptosis and Autophagy via Akt Signaling"],"prefix":"10.1007","volume":"41","author":[{"given":"Wei","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5511-107X","authenticated-orcid":false,"given":"Wei","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"930_CR1","doi-asserted-by":"publisher","first-page":"152883","DOI":"10.1016\/j.phymed.2019.152883","volume":"59","author":"S Ahmed","year":"2019","unstructured":"Ahmed S, Khan H, Fratantonio D, Hasan MM, Sharifi S, Fathi N, Ullah H, Rastrelli L (2019) Apoptosis induced by luteolin in breast cancer: Mechanistic and therapeutic perspectives. Phytomedicine 59:152883. https:\/\/doi.org\/10.1016\/j.phymed.2019.152883","journal-title":"Phytomedicine"},{"issue":"6","key":"930_CR2","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1111\/bcpt.13077","volume":"123","author":"DM Anson","year":"2018","unstructured":"Anson DM, Wilcox RM, Huseman ED, Stump TA, Paris RL, Darkwah BO, Lin S, Adegoke AO, Gryka RJ, Jean-Louis DS, Amos S (2018) Luteolin Decreases Epidermal Growth Factor Receptor-Mediated Cell Proliferation and Induces Apoptosis in Glioblastoma Cell Lines. Basic Clin Pharmacol Toxicol 123(6):678\u2013686. https:\/\/doi.org\/10.1111\/bcpt.13077","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"930_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.10.013","author":"LA Booth","year":"2019","unstructured":"Booth LA, Roberts JL, Dent P (2019) The role of cell signaling in the crosstalk between autophagy and apoptosis in the regulation of tumor cell survival in response to sorafenib and neratinib. Semin Cancer Biol. https:\/\/doi.org\/10.1016\/j.semcancer.2019.10.013","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"930_CR4","doi-asserted-by":"publisher","first-page":"19791","DOI":"10.1038\/s41598-019-56417-8","volume":"9","author":"Q Cao","year":"2019","unstructured":"Cao Q, Shi Y, Wang X, Yang J, Mi Y, Zhai G, Zhang M (2019) Circular METRN RNA hsa_circ_0037251 Promotes Glioma Progression by Sponging miR-1229-3p and Regulating mTOR Expression. Sci Rep 9(1):19791. https:\/\/doi.org\/10.1038\/s41598-019-56417-8","journal-title":"Sci Rep"},{"issue":"7","key":"930_CR5","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1515\/hsz-2016-0307","volume":"398","author":"JH Chen","year":"2017","unstructured":"Chen JH, Zheng YL, Xu CQ, Gu LZ, Ding ZL, Qin L, Wang Y, Fu R, Wan YF, Hu CP (2017) Valproic acid (VPA) enhances cisplatin sensitivity of non-small cell lung cancer cells via HDAC2 mediated down regulation of ABCA1. Biol Chem 398(7):785\u2013792. https:\/\/doi.org\/10.1515\/hsz-2016-0307","journal-title":"Biol Chem"},{"key":"930_CR6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.semcancer.2017.08.005","volume":"46","author":"V Curti","year":"2017","unstructured":"Curti V, Di Lorenzo A, Dacrema M, Xiao J, Nabavi SM, Daglia M (2017) In vitro polyphenol effects on apoptosis: An update of literature data. Semin Cancer Biol 46:119\u2013131. https:\/\/doi.org\/10.1016\/j.semcancer.2017.08.005","journal-title":"Semin Cancer Biol"},{"issue":"4","key":"930_CR7","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1159\/000485753","volume":"44","author":"M Eckert","year":"2017","unstructured":"Eckert M, Klumpp L, Huber SM (2017) Cellular effects of the antiepileptic drug valproic acid in glioblastoma. Cell Physiol 44(4):1591\u20131605. https:\/\/doi.org\/10.1159\/000485753","journal-title":"Cell Physiol"},{"issue":"36","key":"930_CR8","doi-asserted-by":"publisher","first-page":"36545","DOI":"10.1007\/s11356-018-3477-x","volume":"25","author":"D El Gueder","year":"2018","unstructured":"El Gueder D, Maatouk M, Kalboussi Z, Daouefi Z, Chaaban H, Ioannou I, Ghedira K, Ghedira LC, Luis J (2018) Heat processing effect of luteolin on anti-metastasis activity of human glioblastoma cells U87. Environ Sci Pollut Res Int 25(36):36545\u201336554. https:\/\/doi.org\/10.1007\/s11356-018-3477-x","journal-title":"Environ Sci Pollut Res Int"},{"key":"930_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.07.013","author":"L Emdad","year":"2019","unstructured":"Emdad L, Bhoopathi P, Talukdar S, Pradhan AK, Sarkar D, Wang XY, Das SK, Fisher PB (2019) Recent insights into apoptosis and toxic autophagy: the roles of MDA-7\/IL-24, a multidimensional anti-cancer therapeutic. Semin Cancer Biol. https:\/\/doi.org\/10.1016\/j.semcancer.2019.07.013","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"930_CR10","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1080\/21691401.2019.1646749","volume":"47","author":"G Gao","year":"2019","unstructured":"Gao G, Ge R, Li Y, Liu S (2019) Luteolin exhibits anti-breast cancer property through up-regulating miR-203. Artif Cells Nanomed Biotechnol 47(1):3265\u20133271. https:\/\/doi.org\/10.1080\/21691401.2019.1646749","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"8","key":"930_CR11","doi-asserted-by":"publisher","first-page":"6816","DOI":"10.1007\/s12035-018-0895-1","volume":"55","author":"CG Garcia","year":"2018","unstructured":"Garcia CG, Kahn SA, Geraldo LHM, Romano I, Domith I, Silva D, Dos Santos AF, Ferreira MJ, Portugal CC, de Souza JM, Romao LF, Netto ADP, Lima FRS, Cossenza M (2018) Combination therapy with sulfasalazine and valproic acid promotes human glioblastoma cell death through imbalance of the intracellular oxidative response. Mol Neurobiol 55(8):6816\u20136833. https:\/\/doi.org\/10.1007\/s12035-018-0895-1","journal-title":"Mol Neurobiol"},{"issue":"12","key":"930_CR12","first-page":"7568","volume":"11","author":"F Geng","year":"2019","unstructured":"Geng F, Lu GF, Ji MH, Kong DY, Wang SY, Tian H, Xie ZM, Pan M, Gong NL (2019) MicroRNA-26b-3p\/ANTXR1 signaling modulates proliferation, migration, and apoptosis of glioma. Am J Transl Res 11(12):7568\u20137578","journal-title":"Am J Transl Res"},{"issue":"4","key":"930_CR13","doi-asserted-by":"publisher","first-page":"3842","DOI":"10.3892\/ol.2019.10052","volume":"17","author":"L Huang","year":"2019","unstructured":"Huang L, Jin K, Lan H (2019) Luteolin inhibits cell cycle progression and induces apoptosis of breast cancer cells through downregulation of human telomerase reverse transcriptase. Oncol Lett 17(4):3842\u20133850. https:\/\/doi.org\/10.3892\/ol.2019.10052","journal-title":"Oncol Lett"},{"key":"930_CR14","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14334","author":"K Iida","year":"2020","unstructured":"Iida K, Naiki T, Naiki-Ito A, Suzuki S, Kato H, Nozaki S, Nagai T, Etani T, Nagayasu Y, Ando R, Kawai N, Yasui T, Takahashi S (2020) Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway. Cancer Sci. https:\/\/doi.org\/10.1111\/cas.14334","journal-title":"Cancer Sci"},{"key":"930_CR15","doi-asserted-by":"publisher","first-page":"108612","DOI":"10.1016\/j.biopha.2019.108612","volume":"112","author":"M Imran","year":"2019","unstructured":"Imran M, Rauf A, Abu-Izneid T, Nadeem M, Shariati MA, Khan IA, Imran A, Orhan IE, Rizwan M, Atif M, Gondal TA, Mubarak MS (2019) Luteolin, a flavonoid, as an anticancer agent: a review. Biomed Pharmacother 112:108612. https:\/\/doi.org\/10.1016\/j.biopha.2019.108612","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"930_CR16","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00432-019-03118-4","volume":"146","author":"N Kiweler","year":"2020","unstructured":"Kiweler N, Wunsch D, Wirth M, Mahendrarajah N, Schneider G, Stauber RH, Brenner W, Butter F, Kramer OH (2020) Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes. J Cancer Res Clin Oncol 146(2):343\u2013356. https:\/\/doi.org\/10.1007\/s00432-019-03118-4","journal-title":"J Cancer Res Clin Oncol"},{"issue":"4","key":"930_CR17","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1590\/S1415-475738420150028","volume":"38","author":"JE Lee","year":"2015","unstructured":"Lee JE, Kim JH (2015) Valproic acid inhibits the invasion of PC3 prostate cancer cells by upregulating the metastasis suppressor protein NDRG1. Genet Mol Biol 38(4):527\u2013533. https:\/\/doi.org\/10.1590\/S1415-475738420150028","journal-title":"Genet Mol Biol"},{"key":"930_CR18","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13578-019-0312-0","volume":"9","author":"H Li","year":"2019","unstructured":"Li H, Zhang Z, Gao C, Wu S, Duan Q, Wu H, Wang C, Shen Q, Yin T (2019) Combination chemotherapy of valproic acid (VPA) and gemcitabine regulates STAT3\/Bmi1 pathway to differentially potentiate the motility of pancreatic cancer cells. Cell Biosci 9:50. https:\/\/doi.org\/10.1186\/s13578-019-0312-0","journal-title":"Cell Biosci"},{"issue":"5","key":"930_CR19","doi-asserted-by":"publisher","first-page":"3018","DOI":"10.1039\/c8fo00033f","volume":"9","author":"Z Li","year":"2018","unstructured":"Li Z, Zhang Y, Chen L, Li H (2018) The dietary compound luteolin inhibits pancreatic cancer growth by targeting BCL-2. Food Func 9(5):3018\u20133027. https:\/\/doi.org\/10.1039\/c8fo00033f","journal-title":"Food Func"},{"issue":"1","key":"930_CR20","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s13046-019-1160-9","volume":"38","author":"T Lin","year":"2019","unstructured":"Lin T, Ren Q, Zuo W, Jia R, Xie L, Lin R, Zhao H, Chen J, Lei Y, Wang P, Dong H, Huang L, Cai J, Peng Y, Yu Z, Tan J, Wang S (2019) Valproic acid exhibits anti-tumor activity selectively against EGFR\/ErbB2\/ErbB3-coexpressing pancreatic cancer via induction of ErbB family members-targeting microRNAs. J Exp Clin Cancer Res CR 38(1):150. https:\/\/doi.org\/10.1186\/s13046-019-1160-9","journal-title":"J Exp Clin Cancer Res CR"},{"key":"930_CR21","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgz193","author":"A Naiki-Ito","year":"2019","unstructured":"Naiki-Ito A, Naiki T, Kato H, Iida K, Etani T, Nagayasu Y, Suzuki S, Yamashita Y, Inaguma S, Onishi M, Tanaka Y, Yasui T, Takahashi S (2019) Recruitment of miR-8080 by luteolin inhibits androgen receptor splice variant 7 expression in castration-resistant prostate cancer. Carcinogenesis. https:\/\/doi.org\/10.1093\/carcin\/bgz193","journal-title":"Carcinogenesis"},{"issue":"2","key":"930_CR22","doi-asserted-by":"publisher","first-page":"239","DOI":"10.4161\/auto.6.2.11062","volume":"6","author":"L Qin","year":"2010","unstructured":"Qin L, Wang Z, Tao L, Wang Y (2010) ER stress negatively regulates AKT\/TSC\/mTOR pathway to enhance autophagy. Autophagy 6(2):239\u2013247. https:\/\/doi.org\/10.4161\/auto.6.2.11062","journal-title":"Autophagy"},{"key":"930_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/genes9110522","author":"G Riva","year":"2018","unstructured":"Riva G, Cilibrasi C, Bazzoni R, Cadamuro M, Negroni C, Butta V, Strazzabosco M, Dalpra L, Lavitrano M, Bentivegna A (2018) Valproic acid inhibits proliferation and reduces invasiveness in glioma stem cells through Wnt\/beta catenin signalling activation. Genes. https:\/\/doi.org\/10.3390\/genes9110522","journal-title":"Genes"},{"key":"930_CR24","doi-asserted-by":"publisher","first-page":"987495","DOI":"10.1155\/2012\/987495","volume":"2012","author":"CH Ryu","year":"2012","unstructured":"Ryu CH, Yoon WS, Park KY, Kim SM, Lim JY, Woo JS, Jeong CH, Hou Y, Jeun SS (2012) Valproic acid downregulates the expression of MGMT and sensitizes temozolomide-resistant glioma cells. J Biomed Biotechnol 2012:987495. https:\/\/doi.org\/10.1155\/2012\/987495","journal-title":"J Biomed Biotechnol"},{"key":"930_CR25","doi-asserted-by":"publisher","first-page":"29","DOI":"10.34171\/mjiri.33.29","volume":"33","author":"S Sargazi","year":"2019","unstructured":"Sargazi S, Kooshkaki O, Zavar Reza J, Saravani R, Zarei Jaliani H, Mirinejad S, Meshkini F (2019) Mild antagonistic effect of Valproic acid in combination with AZD2461 in MCF-7 breast cancer cells. Med J Islamic Repub Iran 33:29. https:\/\/doi.org\/10.34171\/mjiri.33.29","journal-title":"Med J Islamic Repub Iran"},{"issue":"2","key":"930_CR26","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s11060-018-03043-5","volume":"141","author":"N Shao","year":"2019","unstructured":"Shao N, Mao J, Xue L, Wang R, Zhi F, Lan Q (2019) Carnosic acid potentiates the anticancer effect of temozolomide by inducing apoptosis and autophagy in glioma. J Neurooncol 141(2):277\u2013288. https:\/\/doi.org\/10.1007\/s11060-018-03043-5","journal-title":"J Neurooncol"},{"key":"930_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2019.05.017","volume":"139","author":"S Shirjang","year":"2019","unstructured":"Shirjang S, Mansoori B, Asghari S, Duijf PHG, Mohammadi A, Gjerstorff M, Baradaran B (2019) MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis. Free Radical Biol Med 139:1\u201315. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.05.017","journal-title":"Free Radical Biol Med"},{"issue":"12","key":"930_CR28","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3109\/00207454.2012.714430","volume":"122","author":"CY Song","year":"2012","unstructured":"Song CY, Guo JF, Liu Y, Tang BS (2012) Autophagy and its comprehensive impact on ALS. Int J Neurosci 122(12):695\u2013703. https:\/\/doi.org\/10.3109\/00207454.2012.714430","journal-title":"Int J Neurosci"},{"issue":"10","key":"930_CR29","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1111\/febs.15122","volume":"287","author":"J Sun","year":"2020","unstructured":"Sun J, Piao J, Li N, Yang Y, Kim KY, Lin Z (2020) Valproic acid targets HDAC1\/2 and HDAC1\/PTEN\/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer. FEBS J 287(10):2118\u20132133. https:\/\/doi.org\/10.1111\/febs.15122","journal-title":"FEBS J"},{"issue":"9","key":"930_CR30","doi-asserted-by":"publisher","first-page":"14666","DOI":"10.18632\/oncotarget.14716","volume":"8","author":"JH Tseng","year":"2017","unstructured":"Tseng JH, Chen CY, Chen PC, Hsiao SH, Fan CC, Liang YC, Chen CP (2017) Valproic acid inhibits glioblastoma multiforme cell growth via paraoxonase 2 expression. Oncotarget 8(9):14666\u201314679. https:\/\/doi.org\/10.18632\/oncotarget.14716","journal-title":"Oncotarget"},{"key":"930_CR31","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.pbi.2017.08.011","volume":"40","author":"S Ustun","year":"2017","unstructured":"Ustun S, Hafren A, Hofius D (2017) Autophagy as a mediator of life and death in plants. Curr Opin Plant Biol 40:122\u2013130. https:\/\/doi.org\/10.1016\/j.pbi.2017.08.011","journal-title":"Curr Opin Plant Biol"},{"issue":"12","key":"930_CR32","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1182\/blood-2018-02-791350","volume":"132","author":"R Valentin","year":"2018","unstructured":"Valentin R, Grabow S, Davids MS (2018) The rise of apoptosis: targeting apoptosis in hematologic malignancies. Blood 132(12):1248\u20131264. https:\/\/doi.org\/10.1182\/blood-2018-02-791350","journal-title":"Blood"},{"key":"930_CR33","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.pneurobio.2018.01.001","volume":"163\u2013164","author":"P Wang","year":"2018","unstructured":"Wang P, Shao BZ, Deng Z, Chen S, Yue Z, Miao CY (2018) Autophagy in ischemic stroke. Prog Neurobiol 163\u2013164:98\u2013117. https:\/\/doi.org\/10.1016\/j.pneurobio.2018.01.001","journal-title":"Prog Neurobiol"},{"key":"930_CR34","doi-asserted-by":"publisher","first-page":"7515","DOI":"10.2147\/IJN.S214585","volume":"14","author":"C Wu","year":"2019","unstructured":"Wu C, Xu Q, Chen X, Liu J (2019) Delivery luteolin with folacin-modified nanoparticle for glioma therapy. Int J Nanomed 14:7515\u20137531. https:\/\/doi.org\/10.2147\/IJN.S214585","journal-title":"Int J Nanomed"},{"key":"930_CR35","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.biopha.2016.10.023","volume":"84","author":"L Wu","year":"2016","unstructured":"Wu L, Feng H, Hu J, Tian X, Zhang C (2016) Valproic acid (VPA) promotes the epithelial mesenchymal transition of hepatocarcinoma cells via transcriptional and post-transcriptional up regulation of Snail. Biomed Pharmacother 84:1029\u20131035. https:\/\/doi.org\/10.1016\/j.biopha.2016.10.023","journal-title":"Biomed Pharmacother"},{"issue":"24","key":"930_CR36","doi-asserted-by":"publisher","first-page":"12345","DOI":"10.18632\/aging.102576","volume":"11","author":"Z Xiong","year":"2019","unstructured":"Xiong Z, Zhou C, Wang L, Zhu R, Zhong L, Wan D, Wang Q (2019) Circular RNA SMO sponges miR-338-3p to promote the growth of glioma by enhancing the expression of SMO. Aging (Albany NY) 11(24):12345\u201312360. https:\/\/doi.org\/10.18632\/aging.102576","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"930_CR37","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3892\/ijo.2018.4382","volume":"53","author":"X Xu","year":"2018","unstructured":"Xu X, Wang Z, Liu N, Cheng Y, Jin W, Zhang P, Wang X, Yang H, Liu H, Zhang Y, Tu Y (2018) Association between SOX9 and CA9 in glioma, and its effects on chemosensitivity to TMZ. Int J Oncol 53(1):189\u2013202. https:\/\/doi.org\/10.3892\/ijo.2018.4382","journal-title":"Int J Oncol"},{"issue":"7","key":"930_CR38","first-page":"8291","volume":"8","author":"Y Xu","year":"2015","unstructured":"Xu Y, Xu D, Zhu SJ, Ye B, Dong JD, Zhang YL, Zhang Y (2015) Induction of apoptosis and autophagy in metastatic thyroid cancer cells by valproic acid (VPA). Int J Clin Exp Pathol 8(7):8291\u20138297","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"930_CR39","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3892\/or.2019.7136","volume":"42","author":"Y Yao","year":"2019","unstructured":"Yao Y, Rao C, Zheng G, Wang S (2019) Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR384\/pleiotrophin axis. Oncol Rep 42(1):131\u2013141. https:\/\/doi.org\/10.3892\/or.2019.7136","journal-title":"Oncol Rep"},{"key":"930_CR40","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jns.2016.05.054","volume":"367","author":"GZ Yi","year":"2016","unstructured":"Yi GZ, Liu YW, Xiang W, Wang H, Chen ZY, Xie SD, Qi ST (2016) Akt and beta-catenin contribute to TMZ resistance and EMT of MGMT negative malignant glioma cell line. J Neurol Sci 367:101\u2013106. https:\/\/doi.org\/10.1016\/j.jns.2016.05.054","journal-title":"J Neurol Sci"},{"key":"930_CR41","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.2147\/OTT.S191158","volume":"12","author":"Y You","year":"2019","unstructured":"You Y, Wang R, Shao N, Zhi F, Yang Y (2019) Luteolin suppresses tumor proliferation through inducing apoptosis and autophagy via MAPK activation in glioma. Onco Targets Ther 12:2383\u20132396. https:\/\/doi.org\/10.2147\/OTT.S191158","journal-title":"Onco Targets Ther"},{"issue":"3","key":"930_CR42","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/s41419-019-1447-y","volume":"10","author":"Q Yu","year":"2019","unstructured":"Yu Q, Zhang M, Ying Q, Xie X, Yue S, Tong B, Wei Q, Bai Z, Ma L (2019) Decrease of AIM2 mediated by luteolin contributes to non-small cell lung cancer treatment. Cell Death Dis 10(3):218. https:\/\/doi.org\/10.1038\/s41419-019-1447-y","journal-title":"Cell Death Dis"},{"issue":"6","key":"930_CR43","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1159\/000447912","volume":"39","author":"C Zhang","year":"2016","unstructured":"Zhang C, Liu S, Yuan X, Hu Z, Li H, Wu M, Yuan J, Zhao Z, Su J, Wang X, Liao Y, Liu Q (2016) Valproic acid promotes human glioma U87 cells apoptosis and inhibits glycogen synthase kinase-3beta through ERK\/Akt signaling. Cell Physiol Biochem 39(6):2173\u20132185. https:\/\/doi.org\/10.1159\/000447912","journal-title":"Cell Physiol Biochem"},{"issue":"37","key":"930_CR44","doi-asserted-by":"publisher","first-page":"61146","DOI":"10.18632\/oncotarget.18019","volume":"8","author":"S Zheng","year":"2017","unstructured":"Zheng S, Cheng Y, Teng Y, Liu X, Yu T, Wang Y, Liu J, Hu Y, Wu C, Wang X, Liu Y, You C, Gao X, Wei Y (2017) Application of luteolin nanomicelles anti-glioma effect with improvement in vitro and in vivo. Oncotarget 8(37):61146\u201361162. https:\/\/doi.org\/10.18632\/oncotarget.18019","journal-title":"Oncotarget"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-020-00930-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10571-020-00930-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-020-00930-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T15:59:18Z","timestamp":1633795158000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10571-020-00930-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,27]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["930"],"URL":"https:\/\/doi.org\/10.1007\/s10571-020-00930-2","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,27]]},"assertion":[{"value":"30 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"All the authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest:"}}]}}