{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:23:30Z","timestamp":1782249810160,"version":"3.54.5"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007184","name":"Pr\u00f3-Reitoria de Pesquisa, Universidade Federal do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007184","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007395","name":"Instituto Nacional de Ci\u00eancia e Tecnologia para Excitotoxicidade e Neuroprote\u00e7\u00e3o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10571-020-00981-5","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T11:02:42Z","timestamp":1603191762000},"page":"829-846","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sulforaphane Induces Glioprotection After LPS Challenge"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8318-4818","authenticated-orcid":false,"given":"Larissa Daniele","family":"Bobermin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6001-0567","authenticated-orcid":false,"given":"Fernanda Becker","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-6092","authenticated-orcid":false,"given":"Tiago Marcon","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8340-7759","authenticated-orcid":false,"given":"Adriane","family":"Bell\u00f3-Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8769-1147","authenticated-orcid":false,"given":"Angela T. S.","family":"Wyse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-5650","authenticated-orcid":false,"given":"Carlos-Alberto","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8611-4890","authenticated-orcid":false,"given":"Andr\u00e9","family":"Quincozes-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"981_CR1","doi-asserted-by":"publisher","first-page":"35373","DOI":"10.1074\/jbc.M702175200","volume":"282","author":"MdR Abid","year":"2007","unstructured":"Abid MdR, Spokes KC, Shih S-C, Aird WC (2007) NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways. J Biol Chem 282:35373\u201335385. https:\/\/doi.org\/10.1074\/jbc.M702175200","journal-title":"J Biol Chem"},{"key":"981_CR2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121\u2013126","journal-title":"Methods Enzymol"},{"key":"981_CR3","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1089\/ars.2017.7099","volume":"28","author":"G Aguilera","year":"2018","unstructured":"Aguilera G, Col\u00edn-Gonz\u00e1lez AL, Rangel-L\u00f3pez E et al (2018) Redox signaling, neuroinflammation, and neurodegeneration. Antioxid Redox Signal 28:1626\u20131651. https:\/\/doi.org\/10.1089\/ars.2017.7099","journal-title":"Antioxid Redox Signal"},{"key":"981_CR4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.mce.2008.10.018","volume":"299","author":"JS Allard","year":"2009","unstructured":"Allard JS, Perez E, Zou S, de Cabo R (2009) Dietary activators of Sirt1. Mol Cell Endocrinol 299:58\u201363. https:\/\/doi.org\/10.1016\/j.mce.2008.10.018","journal-title":"Mol Cell Endocrinol"},{"key":"981_CR5","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.neuron.2017.09.056","volume":"96","author":"NJ Allen","year":"2017","unstructured":"Allen NJ, Eroglu C (2017) Cell biology of astrocyte-synapse interactions. Neuron 96:697\u2013708. https:\/\/doi.org\/10.1016\/j.neuron.2017.09.056","journal-title":"Neuron"},{"key":"981_CR6","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.pharmthera.2013.01.004","volume":"138","author":"SJ Allen","year":"2013","unstructured":"Allen SJ, Watson JJ, Shoemark DK et al (2013) GDNF, NGF and BDNF as therapeutic options for neurodegeneration. Pharmacol Ther 138:155\u2013175. https:\/\/doi.org\/10.1016\/j.pharmthera.2013.01.004","journal-title":"Pharmacol Ther"},{"key":"981_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.neulet.2013.12.030","volume":"565","author":"MA Anderson","year":"2014","unstructured":"Anderson MA, Ao Y, Sofroniew MV (2014) Heterogeneity of reactive astrocytes. Neurosci Lett 565:23\u201329. https:\/\/doi.org\/10.1016\/j.neulet.2013.12.030","journal-title":"Neurosci Lett"},{"key":"981_CR8","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s11010-016-2917-5","volume":"428","author":"BA Ar\u00fas","year":"2017","unstructured":"Ar\u00fas BA, Souza DG, Bellaver B et al (2017) Resveratrol modulates GSH system in C6 astroglial cells through heme oxygenase 1 pathway. Mol Cell Biochem 428:67\u201377. https:\/\/doi.org\/10.1007\/s11010-016-2917-5","journal-title":"Mol Cell Biochem"},{"key":"981_CR9","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah4477","author":"AS Axelsson","year":"2017","unstructured":"Axelsson AS, Tubbs E, Mecham B et al (2017) Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Sci Transl Med. https:\/\/doi.org\/10.1126\/scitranslmed.aah4477","journal-title":"Sci Transl Med"},{"key":"981_CR10","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.cmet.2011.08.016","volume":"14","author":"M B\u00e9langer","year":"2011","unstructured":"B\u00e9langer M, Allaman I, Magistretti PJ (2011) Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab 14:724\u2013738. https:\/\/doi.org\/10.1016\/j.cmet.2011.08.016","journal-title":"Cell Metab"},{"key":"981_CR11","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s11302-015-9475-2","volume":"11","author":"B Bellaver","year":"2015","unstructured":"Bellaver B, Souza DG, Bobermin LD et al (2015) Guanosine inhibits LPS-induced pro-inflammatory response and oxidative stress in hippocampal astrocytes through the heme oxygenase-1 pathway. Purinergic Signal 11:571\u2013580. https:\/\/doi.org\/10.1007\/s11302-015-9475-2","journal-title":"Purinergic Signal"},{"key":"981_CR12","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.neuropharm.2010.09.023","volume":"60","author":"P Bergstr\u00f6m","year":"2011","unstructured":"Bergstr\u00f6m P, Andersson HC, Gao Y et al (2011) Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage. Neuropharmacology 60:343\u2013353. https:\/\/doi.org\/10.1016\/j.neuropharm.2010.09.023","journal-title":"Neuropharmacology"},{"key":"981_CR13","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1016\/j.tiv.2015.08.008","volume":"29","author":"LD Bobermin","year":"2015","unstructured":"Bobermin LD, Hansel G, Scherer EBS et al (2015) Ammonia impairs glutamatergic communication in astroglial cells: protective role of resveratrol. Toxicol Vitro Int J Publ Assoc BIBRA 29:2022\u20132029. https:\/\/doi.org\/10.1016\/j.tiv.2015.08.008","journal-title":"Toxicol Vitro Int J Publ Assoc BIBRA"},{"key":"981_CR14","doi-asserted-by":"publisher","first-page":"e52164","DOI":"10.1371\/journal.pone.0052164","volume":"7","author":"LD Bobermin","year":"2012","unstructured":"Bobermin LD, Quincozes-Santos A, Guerra MC et al (2012) Resveratrol prevents ammonia toxicity in astroglial cells. PLoS ONE 7:e52164. https:\/\/doi.org\/10.1371\/journal.pone.0052164","journal-title":"PLoS ONE"},{"key":"981_CR15","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.bbadis.2019.01.004","volume":"1865","author":"LD Bobermin","year":"2019","unstructured":"Bobermin LD, Roppa RHA, Quincozes-Santos A (2019) Adenosine receptors as a new target for resveratrol-mediated glioprotection. Biochim Biophys Acta Mol Basis Dis 1865:634\u2013647. https:\/\/doi.org\/10.1016\/j.bbadis.2019.01.004","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"981_CR16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/jnc.13486","volume":"139","author":"JP Bola\u00f1os","year":"2016","unstructured":"Bola\u00f1os JP (2016) Bioenergetics and redox adaptations of astrocytes to neuronal activity. J Neurochem 139:115\u2013125. https:\/\/doi.org\/10.1111\/jnc.13486","journal-title":"J Neurochem"},{"key":"981_CR17","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1002\/mnfr.201400104","volume":"58","author":"GV Bricker","year":"2014","unstructured":"Bricker GV, Riedl KM, Ralston RA et al (2014) Isothiocyanate metabolism, distribution, and interconversion in mice following consumption of thermally processed broccoli sprouts or purified sulforaphane. Mol Nutr Food Res 58:1991\u20132000. https:\/\/doi.org\/10.1002\/mnfr.201400104","journal-title":"Mol Nutr Food Res"},{"key":"981_CR18","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1385\/0-89603-472-0:347","volume-title":"Free radical and antioxidant protocols","author":"RW Browne","year":"1998","unstructured":"Browne RW, Armstrong D (1998) Reduced glutathione and glutathione disulfide. Free radical and antioxidant protocols. Humana Press, New Jersey, pp 347\u2013352"},{"key":"981_CR19","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/0003-2697(86)90640-8","volume":"157","author":"KM Chan","year":"1986","unstructured":"Chan KM, Delfert D, Junger KD (1986) A direct colorimetric assay for Ca2+ -stimulated ATPase activity. Anal Biochem 157:375\u2013380","journal-title":"Anal Biochem"},{"key":"981_CR20","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2013-0046","author":"J Chen","year":"2014","unstructured":"Chen J (2014) Heme oxygenase in neuroprotection: from mechanisms to therapeutic implications. Rev Neurosci. https:\/\/doi.org\/10.1515\/revneuro-2013-0046","journal-title":"Rev Neurosci"},{"key":"981_CR21","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1007\/s11095-011-0500-z","volume":"28","author":"JD Clarke","year":"2011","unstructured":"Clarke JD, Hsu A, Williams DE et al (2011) Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharm Res 28:3171\u20133179. https:\/\/doi.org\/10.1007\/s11095-011-0500-z","journal-title":"Pharm Res"},{"key":"981_CR22","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.it.2016.06.006","volume":"37","author":"E Colombo","year":"2016","unstructured":"Colombo E, Farina C (2016) Astrocytes: key regulators of neuroinflammation. Trends Immunol 37:608\u2013620. https:\/\/doi.org\/10.1016\/j.it.2016.06.006","journal-title":"Trends Immunol"},{"key":"981_CR23","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.biopha.2018.05.031","volume":"104","author":"GB Corssac","year":"2018","unstructured":"Corssac GB, Campos-Carraro C, Hickmann A et al (2018) Sulforaphane effects on oxidative stress parameters in culture of adult cardiomyocytes. Biomed Pharmacother 104:165\u2013171. https:\/\/doi.org\/10.1016\/j.biopha.2018.05.031","journal-title":"Biomed Pharmacother"},{"key":"981_CR24","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.molmed.2019.09.007","volume":"26","author":"X Dai","year":"2020","unstructured":"Dai X, Yan X, Wintergerst KA et al (2020) Nrf2: redox and metabolic regulator of stem cell state and function. Trends Mol Med 26:185\u2013200. https:\/\/doi.org\/10.1016\/j.molmed.2019.09.007","journal-title":"Trends Mol Med"},{"key":"981_CR25","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1002\/glia.20793","volume":"57","author":"CA Danilov","year":"2009","unstructured":"Danilov CA, Chandrasekaran K, Racz J et al (2009) Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation. Glia 57:645\u2013656. https:\/\/doi.org\/10.1002\/glia.20793","journal-title":"Glia"},{"key":"981_CR26","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.bbamcr.2008.11.009","volume":"1793","author":"R Donato","year":"2009","unstructured":"Donato R, Sorci G, Riuzzi F et al (2009) S100B\u2019s double life: intracellular regulator and extracellular signal. Biochim Biophys Acta 1793:1008\u20131022. https:\/\/doi.org\/10.1016\/j.bbamcr.2008.11.009","journal-title":"Biochim Biophys Acta"},{"key":"981_CR27","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.abb.2006.06.025","volume":"453","author":"AQ dos Santos","year":"2006","unstructured":"dos Santos AQ, Nardin P, Funchal C et al (2006) Resveratrol increases glutamate uptake and glutamine synthetase activity in C6 glioma cells. Arch Biochem Biophys 453:161\u2013167. https:\/\/doi.org\/10.1016\/j.abb.2006.06.025","journal-title":"Arch Biochem Biophys"},{"key":"981_CR28","doi-asserted-by":"publisher","first-page":"5310","DOI":"10.1007\/s12035-015-9451-4","volume":"53","author":"S Dwivedi","year":"2016","unstructured":"Dwivedi S, Rajasekar N, Hanif K et al (2016) Sulforaphane ameliorates okadaic acid-induced memory impairment in rats by activating the Nrf2\/HO-1 antioxidant pathway. Mol Neurobiol 53:5310\u20135323. https:\/\/doi.org\/10.1007\/s12035-015-9451-4","journal-title":"Mol Neurobiol"},{"key":"981_CR29","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s12035-015-9643-y","volume":"54","author":"S Feng","year":"2017","unstructured":"Feng S, Xu Z, Wang F et al (2017) Sulforaphane prevents methylmercury-induced oxidative damage and excitotoxicity through activation of the Nrf2-ARE pathway. Mol Neurobiol 54:375\u2013391. https:\/\/doi.org\/10.1007\/s12035-015-9643-y","journal-title":"Mol Neurobiol"},{"key":"981_CR30","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s11010-014-2292-z","volume":"401","author":"RO Fernandes","year":"2015","unstructured":"Fernandes RO, Bonetto JHP, Baregzay B et al (2015) Modulation of apoptosis by sulforaphane is associated with PGC-1\u03b1 stimulation and decreased oxidative stress in cardiac myoblasts. Mol Cell Biochem 401:61\u201370. https:\/\/doi.org\/10.1007\/s11010-014-2292-z","journal-title":"Mol Cell Biochem"},{"key":"981_CR31","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jnutbio.2016.05.004","volume":"34","author":"RO Fernandes","year":"2016","unstructured":"Fernandes RO, De Castro AL, Bonetto JHP et al (2016) Sulforaphane effects on postinfarction cardiac remodeling in rats: modulation of redox-sensitive prosurvival and proapoptotic proteins. J Nutr Biochem 34:106\u2013117. https:\/\/doi.org\/10.1016\/j.jnutbio.2016.05.004","journal-title":"J Nutr Biochem"},{"key":"981_CR32","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41593-018-0286-y","volume":"22","author":"C Garc\u00eda-C\u00e1ceres","year":"2019","unstructured":"Garc\u00eda-C\u00e1ceres C, Balland E, Prevot V et al (2019) Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism. Nat Neurosci 22:7\u201314. https:\/\/doi.org\/10.1038\/s41593-018-0286-y","journal-title":"Nat Neurosci"},{"key":"981_CR33","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.phrs.2013.08.002","volume":"76","author":"S Gessi","year":"2013","unstructured":"Gessi S, Merighi S, Stefanelli A et al (2013) A1 and A3 adenosine receptors inhibit LPS-induced hypoxia-inducible factor-1 accumulation in murine astrocytes. Pharmacol Res 76:157\u2013170. https:\/\/doi.org\/10.1016\/j.phrs.2013.08.002","journal-title":"Pharmacol Res"},{"key":"981_CR34","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.clinbiochem.2008.04.003","volume":"41","author":"C-A Gon\u00e7alves","year":"2008","unstructured":"Gon\u00e7alves C-A, Concli Leite M, Nardin P (2008) Biological and methodological features of the measurement of S100B, a putative marker of brain injury. Clin Biochem 41:755\u2013763. https:\/\/doi.org\/10.1016\/j.clinbiochem.2008.04.003","journal-title":"Clin Biochem"},{"key":"981_CR35","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1002\/glia.21094","volume":"59","author":"R Gorina","year":"2011","unstructured":"Gorina R, Font-Nieves M, M\u00e1rquez-Kisinousky L et al (2011) Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NF\u03baB signaling, MAPK, and Jak1\/Stat1 pathways. Glia 59:242\u2013255. https:\/\/doi.org\/10.1002\/glia.21094","journal-title":"Glia"},{"key":"981_CR36","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/s41583-020-0263-9","volume":"21","author":"AD Greenhalgh","year":"2020","unstructured":"Greenhalgh AD, David S, Bennett FC (2020) Immune cell regulation of glia during CNS injury and disease. Nat Rev Neurosci 21:139\u2013152. https:\/\/doi.org\/10.1038\/s41583-020-0263-9","journal-title":"Nat Rev Neurosci"},{"key":"981_CR37","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/1742-2094-8-128","volume":"8","author":"M Guerra","year":"2011","unstructured":"Guerra M, Tortorelli LS, Galland F et al (2011) Lipopolysaccharide modulates astrocytic S100B secretion: a study in cerebrospinal fluid and astrocyte cultures from rats. J Neuroinflamm 8:128. https:\/\/doi.org\/10.1186\/1742-2094-8-128","journal-title":"J Neuroinflamm"},{"key":"981_CR38","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1042\/CS20110164","volume":"121","author":"ML Hanke","year":"2011","unstructured":"Hanke ML, Kielian T (2011) Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin Sci Lond Engl 1979 121:367\u2013387. https:\/\/doi.org\/10.1042\/CS20110164","journal-title":"Clin Sci Lond Engl 1979"},{"key":"981_CR39","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1089\/neu.2009.1075","volume":"27","author":"ML Haselkorn","year":"2010","unstructured":"Haselkorn ML, Shellington DK, Jackson EK et al (2010) Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice. J Neurotrauma 27:901\u2013910. https:\/\/doi.org\/10.1089\/neu.2009.1075","journal-title":"J Neurotrauma"},{"key":"981_CR40","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.neuropharm.2009.11.003","volume":"58","author":"S-Y Hung","year":"2010","unstructured":"Hung S-Y, Liou H-C, Fu W-M (2010) The mechanism of heme oxygenase-1 action involved in the enhancement of neurotrophic factor expression. Neuropharmacology 58:321\u2013329. https:\/\/doi.org\/10.1016\/j.neuropharm.2009.11.003","journal-title":"Neuropharmacology"},{"key":"981_CR41","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1007\/s11481-013-9480-6","volume":"8","author":"CJ Jensen","year":"2013","unstructured":"Jensen CJ, Massie A, De Keyser J (2013) Immune players in the CNS: the astrocyte. J Neuroimmune Pharmacol 8:824\u2013839. https:\/\/doi.org\/10.1007\/s11481-013-9480-6","journal-title":"J Neuroimmune Pharmacol"},{"key":"981_CR42","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1096\/fj.09-149997","volume":"24","author":"M Lee","year":"2010","unstructured":"Lee M, Cho T, Jantaratnotai N et al (2010) Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases. FASEB J 24:2533\u20132545. https:\/\/doi.org\/10.1096\/fj.09-149997","journal-title":"FASEB J"},{"key":"981_CR43","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jneumeth.2007.11.021","volume":"169","author":"MC Leite","year":"2008","unstructured":"Leite MC, Galland F, Brolese G et al (2008) A simple, sensitive and widely applicable ELISA for S100B: methodological features of the measurement of this glial protein. J Neurosci Methods 169:93\u201399. https:\/\/doi.org\/10.1016\/j.jneumeth.2007.11.021","journal-title":"J Neurosci Methods"},{"key":"981_CR44","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1007\/s12031-015-0526-5","volume":"56","author":"L Li","year":"2015","unstructured":"Li L, Sun Q, Li Y et al (2015) Overexpression of SIRT1 induced by resveratrol and inhibitor of miR-204 suppresses activation and proliferation of microglia. J Mol Neurosci 56:858\u2013867. https:\/\/doi.org\/10.1007\/s12031-015-0526-5","journal-title":"J Mol Neurosci"},{"key":"981_CR45","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3390\/antiox6030065","volume":"6","author":"J Liddell","year":"2017","unstructured":"Liddell J (2017) Are astrocytes the predominant cell type for activation of Nrf2 in aging and neurodegeneration? Antioxidants 6:65. https:\/\/doi.org\/10.3390\/antiox6030065","journal-title":"Antioxidants"},{"key":"981_CR46","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/jnc.12647","volume":"129","author":"Y Liu","year":"2014","unstructured":"Liu Y, Hettinger CL, Zhang D et al (2014) Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington\u2019s disease. J Neurochem 129:539\u2013547. https:\/\/doi.org\/10.1111\/jnc.12647","journal-title":"J Neurochem"},{"key":"981_CR47","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods San Diego Calif 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods San Diego Calif"},{"key":"981_CR48","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"981_CR49","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1016\/j.bbagen.2012.09.008","volume":"1830","author":"SC Lu","year":"2013","unstructured":"Lu SC (2013) Glutathione synthesis. Biochim Biophys Acta 1830:3143\u20133153. https:\/\/doi.org\/10.1016\/j.bbagen.2012.09.008","journal-title":"Biochim Biophys Acta"},{"key":"981_CR50","doi-asserted-by":"crossref","first-page":"343","DOI":"10.55782\/ane-2006-1623","volume":"66","author":"I Markiewicz","year":"2006","unstructured":"Markiewicz I, Lukomska B (2006) The role of astrocytes in the physiology and pathology of the central nervous system. Acta Neurobiol Exp (Warsz) 66:343\u2013358","journal-title":"Acta Neurobiol Exp (Warsz)"},{"key":"981_CR51","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1002\/glia.22861","volume":"63","author":"S Merighi","year":"2015","unstructured":"Merighi S, Borea PA, Stefanelli A et al (2015) A 2a and a 2b adenosine receptors affect HIF-1\u03b1 signaling in activated primary microglial cells: adenosine receptors in microglial cells. Glia 63:1933\u20131952. https:\/\/doi.org\/10.1002\/glia.22861","journal-title":"Glia"},{"key":"981_CR52","doi-asserted-by":"publisher","first-page":"3138","DOI":"10.1007\/s11064-016-2038-2","volume":"41","author":"M Moriyama","year":"2016","unstructured":"Moriyama M, Kurebayashi R, Kawabe K et al (2016) Acetate attenuates lipopolysaccharide-induced nitric oxide production through an anti-oxidative mechanism in cultured primary rat astrocytes. Neurochem Res 41:3138\u20133146. https:\/\/doi.org\/10.1007\/s11064-016-2038-2","journal-title":"Neurochem Res"},{"key":"981_CR53","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.brainres.2014.10.059","volume":"1594","author":"EA Newell","year":"2015","unstructured":"Newell EA, Exo JL, Verrier JD et al (2015) 2\u2019,3\u2019-cAMP, 3\u2019-AMP, 2\u2019-AMP and adenosine inhibit TNF-\u03b1 and CXCL10 production from activated primary murine microglia via A2A receptors. Brain Res 1594:27\u201335. https:\/\/doi.org\/10.1016\/j.brainres.2014.10.059","journal-title":"Brain Res"},{"key":"981_CR54","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.freeradbiomed.2013.02.008","volume":"66","author":"SK Niture","year":"2014","unstructured":"Niture SK, Khatri R, Jaiswal AK (2014) Regulation of Nrf2\u2014an update. Free Radic Biol Med 66:36\u201344. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2013.02.008","journal-title":"Free Radic Biol Med"},{"key":"981_CR55","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.immuni.2014.09.008","volume":"41","author":"A Palazon","year":"2014","unstructured":"Palazon A, Goldrath A, Nizet V, Johnson RS (2014) HIF Transcription factors, inflammation, and immunity. Immunity 41:518\u2013528. https:\/\/doi.org\/10.1016\/j.immuni.2014.09.008","journal-title":"Immunity"},{"key":"981_CR56","doi-asserted-by":"publisher","first-page":"e114186","DOI":"10.1371\/journal.pone.0114186","volume":"9","author":"H Pan","year":"2014","unstructured":"Pan H, He M, Liu R et al (2014) Sulforaphane protects rodent retinas against ischemia-reperfusion injury through the activation of the Nrf2\/HO-1 antioxidant pathway. PLoS ONE 9:e114186. https:\/\/doi.org\/10.1371\/journal.pone.0114186","journal-title":"PLoS ONE"},{"key":"981_CR57","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1002\/mnfr.201500279","volume":"59","author":"E Parada","year":"2015","unstructured":"Parada E, Buendia I, Navarro E et al (2015) Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects. Mol Nutr Food Res 59:1690\u20131700. https:\/\/doi.org\/10.1002\/mnfr.201500279","journal-title":"Mol Nutr Food Res"},{"key":"981_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbadis.2016.09.013","volume":"1863","author":"A Quincozes-Santos","year":"2017","unstructured":"Quincozes-Santos A, Bobermin LD, de Assis AM et al (2017) Fluctuations in glucose levels induce glial toxicity with glutamatergic, oxidative and inflammatory implications. Biochim Biophys Acta BBA 1863:1\u201314. https:\/\/doi.org\/10.1016\/j.bbadis.2016.09.013","journal-title":"Biochim Biophys Acta BBA"},{"key":"981_CR59","doi-asserted-by":"publisher","first-page":"e64372","DOI":"10.1371\/journal.pone.0064372","volume":"8","author":"A Quincozes-Santos","year":"2013","unstructured":"Quincozes-Santos A, Bobermin LD, Latini A et al (2013) Resveratrol protects C6 astrocyte cell line against hydrogen peroxide-induced oxidative stress through heme oxygenase 1. PLoS ONE 8:e64372. https:\/\/doi.org\/10.1371\/journal.pone.0064372","journal-title":"PLoS ONE"},{"key":"981_CR60","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/jnc.12694","volume":"130","author":"A Quincozes-Santos","year":"2014","unstructured":"Quincozes-Santos A, Bobermin LD, Souza DG et al (2014) Guanosine protects C6 astroglial cells against azide-induced oxidative damage: a putative role of heme oxygenase 1. J Neurochem 130:61\u201374. https:\/\/doi.org\/10.1111\/jnc.12694","journal-title":"J Neurochem"},{"key":"981_CR61","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.nbd.2012.04.014","volume":"47","author":"SM Rocha","year":"2012","unstructured":"Rocha SM, Cristov\u00e3o AC, Campos FL et al (2012) Astrocyte-derived GDNF is a potent inhibitor of microglial activation. Neurobiol Dis 47:407\u2013415. https:\/\/doi.org\/10.1016\/j.nbd.2012.04.014","journal-title":"Neurobiol Dis"},{"key":"981_CR62","doi-asserted-by":"publisher","first-page":"3875","DOI":"10.1007\/s12035-017-0618-z","volume":"55","author":"G Rosciszewski","year":"2018","unstructured":"Rosciszewski G, Cadena V, Murta V et al (2018) Toll-like receptor 4 (TLR4) and triggering receptor expressed on myeloid cells-2 (TREM-2) activation balance astrocyte polarization into a proinflammatory phenotype. Mol Neurobiol 55:3875\u20133888. https:\/\/doi.org\/10.1007\/s12035-017-0618-z","journal-title":"Mol Neurobiol"},{"key":"981_CR63","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3390\/antiox9020136","volume":"9","author":"RT Ruhee","year":"2020","unstructured":"Ruhee RT, Ma S, Suzuki K (2020) Protective effects of sulforaphane on exercise-induced organ damage via inducing antioxidant defense responses. Antioxidants 9:136. https:\/\/doi.org\/10.3390\/antiox9020136","journal-title":"Antioxidants"},{"key":"981_CR64","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.trsl.2015.06.011","volume":"167","author":"SW Ryter","year":"2016","unstructured":"Ryter SW, Choi AMK (2016) Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation. Transl Res 167:7\u201334. https:\/\/doi.org\/10.1016\/j.trsl.2015.06.011","journal-title":"Transl Res"},{"key":"981_CR65","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1016\/j.tiv.2015.05.023","volume":"29","author":"CL Santos","year":"2015","unstructured":"Santos CL, Bobermin LD, Souza DG et al (2015) Lipoic acid and N-acetylcysteine prevent ammonia-induced inflammatory response in C6 astroglial cells: the putative role of ERK and HO1 signaling pathways. Toxicol In Vitro 29:1350\u20131357. https:\/\/doi.org\/10.1016\/j.tiv.2015.05.023","journal-title":"Toxicol In Vitro"},{"key":"981_CR66","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neulet.2018.01.038","volume":"689","author":"A Schousboe","year":"2019","unstructured":"Schousboe A (2019) Metabolic signaling in the brain and the role of astrocytes in control of glutamate and GABA neurotransmission. Neurosci Lett 689:11\u201313. https:\/\/doi.org\/10.1016\/j.neulet.2018.01.038","journal-title":"Neurosci Lett"},{"key":"981_CR67","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0076-6879(85)13050-8","volume":"113","author":"GF Seelig","year":"1985","unstructured":"Seelig GF, Meister A (1985) Glutathione biosynthesis; gamma-glutamylcysteine synthetase from rat kidney. Methods Enzymol 113:379\u2013390","journal-title":"Methods Enzymol"},{"key":"981_CR68","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.neuint.2015.06.004","volume":"87","author":"N Sharma","year":"2015","unstructured":"Sharma N, Nehru B (2015) Characterization of the lipopolysaccharide induced model of Parkinson\u2019s disease: role of oxidative stress and neuroinflammation. Neurochem Int 87:92\u2013105. https:\/\/doi.org\/10.1016\/j.neuint.2015.06.004","journal-title":"Neurochem Int"},{"key":"981_CR69","doi-asserted-by":"publisher","first-page":"104728","DOI":"10.1016\/j.neuint.2020.104728","volume":"136","author":"L Tang","year":"2020","unstructured":"Tang L, Ren X, Han Y et al (2020) Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose via regulating endoplasmic reticulum. Neurochem Int 136:104728. https:\/\/doi.org\/10.1016\/j.neuint.2020.104728","journal-title":"Neurochem Int"},{"key":"981_CR70","doi-asserted-by":"publisher","first-page":"415078","DOI":"10.1155\/2013\/415078","volume":"2013","author":"A Tarozzi","year":"2013","unstructured":"Tarozzi A, Angeloni C, Malaguti M et al (2013) Sulforaphane as a potential protective phytochemical against neurodegenerative diseases. Oxid Med Cell Longev 2013:415078. https:\/\/doi.org\/10.1155\/2013\/415078","journal-title":"Oxid Med Cell Longev"},{"key":"981_CR71","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1089\/ars.2014.6097","volume":"22","author":"SM Tortorella","year":"2015","unstructured":"Tortorella SM, Royce SG, Licciardi PV, Karagiannis TC (2015) Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition. Antioxid Redox Signal 22:1382\u20131424. https:\/\/doi.org\/10.1089\/ars.2014.6097","journal-title":"Antioxid Redox Signal"},{"key":"981_CR72","doi-asserted-by":"publisher","first-page":"135624","DOI":"10.1016\/j.scitotenv.2019.135624","volume":"707","author":"MdS Uddin","year":"2020","unstructured":"Uddin MdS, Mamun AA, Jakaria Md et al (2020) Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders. Sci Total Environ 707:135624. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.135624","journal-title":"Sci Total Environ"},{"key":"981_CR73","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.tins.2020.01.003","volume":"43","author":"ID Vainchtein","year":"2020","unstructured":"Vainchtein ID, Molofsky AV (2020) Astrocytes and microglia: in sickness and in health. Trends Neurosci 43:144\u2013154. https:\/\/doi.org\/10.1016\/j.tins.2020.01.003","journal-title":"Trends Neurosci"},{"key":"981_CR74","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.molmed.2019.04.010","volume":"25","author":"CF Valori","year":"2019","unstructured":"Valori CF, Guidotti G, Brambilla L, Rossi D (2019) Astrocytes: emerging therapeutic targets in neurological disorders. Trends Mol Med 25:750\u2013759. https:\/\/doi.org\/10.1016\/j.molmed.2019.04.010","journal-title":"Trends Mol Med"},{"key":"981_CR75","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1042\/BJ20080476","volume":"412","author":"P van Uden","year":"2008","unstructured":"van Uden P, Kenneth NS, Rocha S (2008) Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. Biochem J 412:477\u2013484. https:\/\/doi.org\/10.1042\/BJ20080476","journal-title":"Biochem J"},{"key":"981_CR76","doi-asserted-by":"publisher","first-page":"13574","DOI":"10.1523\/JNEUROSCI.4099-08.2008","volume":"28","author":"MR Vargas","year":"2008","unstructured":"Vargas MR, Johnson DA, Sirkis DW et al (2008) Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis. J Neurosci 28:13574\u201313581. https:\/\/doi.org\/10.1523\/JNEUROSCI.4099-08.2008","journal-title":"J Neurosci"},{"key":"981_CR77","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/jnc.12790","volume":"131","author":"A Villarreal","year":"2014","unstructured":"Villarreal A, Seoane R, Gonz\u00e1lez Torres A et al (2014) S100B protein activates a RAGE-dependent autocrine loop in astrocytes: implications for its role in the propagation of reactive gliosis. J Neurochem 131:190\u2013205. https:\/\/doi.org\/10.1111\/jnc.12790","journal-title":"J Neurochem"},{"key":"981_CR78","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1089\/ars.2010.3216","volume":"13","author":"N Wakabayashi","year":"2010","unstructured":"Wakabayashi N, Slocum SL, Skoko JJ et al (2010) When NRF2 talks, who\u2019s listening? Antioxid Redox Signal 13:1649\u20131663. https:\/\/doi.org\/10.1089\/ars.2010.3216","journal-title":"Antioxid Redox Signal"},{"key":"981_CR79","doi-asserted-by":"publisher","first-page":"134387","DOI":"10.1016\/j.neulet.2019.134387","volume":"711","author":"Y Wang","year":"2019","unstructured":"Wang Y, Zhao C-S (2019) Sigma-1 receptor activation ameliorates LPS-induced NO production and ROS formation through the Nrf2\/HO-1 signaling pathway in cultured astrocytes. Neurosci Lett 711:134387. https:\/\/doi.org\/10.1016\/j.neulet.2019.134387","journal-title":"Neurosci Lett"},{"key":"981_CR80","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1097\/00001756-200007140-00052","volume":"11","author":"AT Wyse","year":"2000","unstructured":"Wyse AT, Streck EL, Barros SV et al (2000) Methylmalonate administration decreases Na+, K+-ATPase activity in cerebral cortex of rats. NeuroReport 11:2331\u20132334","journal-title":"NeuroReport"},{"key":"981_CR81","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.neuint.2007.12.009","volume":"52","author":"BK Yoo","year":"2008","unstructured":"Yoo BK, Choi JW, Shin CY et al (2008) Activation of p38 MAPK induced peroxynitrite generation in LPS plus IFN-gamma-stimulated rat primary astrocytes via activation of iNOS and NADPH oxidase. Neurochem Int 52:1188\u20131197. https:\/\/doi.org\/10.1016\/j.neuint.2007.12.009","journal-title":"Neurochem Int"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-020-00981-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10571-020-00981-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-020-00981-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T04:09:10Z","timestamp":1723781350000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10571-020-00981-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,20]]},"references-count":81,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["981"],"URL":"https:\/\/doi.org\/10.1007\/s10571-020-00981-5","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,20]]},"assertion":[{"value":"9 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}