{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:02:14Z","timestamp":1793833334876,"version":"4.6.1"},"reference-count":102,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["31900694"],"award-info":[{"award-number":["31900694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s10571-021-01176-2","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:05:58Z","timestamp":1641427558000},"page":"69-78","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Mechanism Underlying the Regulation of Long Non-coding RNA MEG3 in Cerebral Ischemic Stroke"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-9046","authenticated-orcid":false,"given":"Yanfang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"issue":"2","key":"1176_CR1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3390\/cells9020269","volume":"9","author":"I Ahmad","year":"2020","unstructured":"Ahmad I, Valverde A, Ahmad F, Naqvi AR (2020) Long noncoding RNA in myeloid and lymphoid cell differentiation, polarization and function. Cells 9(2):269","journal-title":"Cells"},{"key":"1176_CR2","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1007\/s11011-019-00423-2","volume":"34","author":"M Alishahi","year":"2019","unstructured":"Alishahi M, Ghaedrahmati F, Kolagar TA, Winlow W, Nikkar N, Farzaneh M, Khoshnam SE (2019) Long non-coding RNAs and cell death following ischemic stroke. Metab Brain Dis 34:1243\u20131251","journal-title":"Metab Brain Dis"},{"key":"1176_CR3","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41419-018-0282-x","volume":"9","author":"MH Bao","year":"2018","unstructured":"Bao MH, Szeto V, Yang BB, Zhu SZ, Sun HS, Feng ZP (2018) Long non-coding RNAs in ischemic stroke. Cell Death Dis 9:281","journal-title":"Cell Death Dis"},{"key":"1176_CR4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.neurol.2015.07.013","volume":"172","author":"Y Bejot","year":"2016","unstructured":"Bejot Y, Daubail B, Giroud M (2016) Epidemiology of stroke and transient ischemic attacks: Current knowledge and perspectives. Rev Neurol (paris) 172:59\u201368","journal-title":"Rev Neurol (paris)"},{"key":"1176_CR5","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1002\/ijc.26052","volume":"129","author":"L Benetatos","year":"2011","unstructured":"Benetatos L, Vartholomatos G, Hatzimichael E (2011) MEG3 imprinted gene contribution in tumorigenesis. Int J Cancer 129:773\u2013779","journal-title":"Int J Cancer"},{"key":"1176_CR6","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1080\/17460441.2018.1501024","volume":"13","author":"I Blokhin","year":"2018","unstructured":"Blokhin I, Khorkova O, Hsiao J, Wahlestedt C (2018) Developments in lncRNA drug discovery: where are we heading? Expert Opin Drug Discov 13:837\u2013849","journal-title":"Expert Opin Drug Discov"},{"key":"1176_CR7","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1161\/CIRCRESAHA.116.309278","volume":"120","author":"L Catanese","year":"2017","unstructured":"Catanese L, Tarsia J, Fisher M (2017) Acute ischemic stroke therapy overview. Circ Res 120:541\u2013558","journal-title":"Circ Res"},{"key":"1176_CR8","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.tibs.2016.07.003","volume":"41","author":"LL Chen","year":"2016","unstructured":"Chen LL (2016) Linking long noncoding RNA localization and function. Trends Biochem Sci 41:761\u2013772","journal-title":"Trends Biochem Sci"},{"key":"1176_CR9","first-page":"5366","volume":"23","author":"J Chen","year":"2019","unstructured":"Chen J, Zhang W, Wu YQ, Chen H, Zhao JF (2019) LncRNA SNHG1 inhibits neuronal apoptosis in cerebral infarction rats through PI3K\/Akt signaling pathway. Eur Rev Med Pharmacol Sci 23:5366\u20135373","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1176_CR10","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.tig.2008.03.011","volume":"24","author":"ST da Rocha","year":"2008","unstructured":"da Rocha ST, Edwards CA, Ito M, Ogata T, Ferguson-Smith AC (2008) Genomic imprinting at the mammalian Dlk1-Dio3 domain. Trends Genet (TIG) 24:306\u2013316","journal-title":"Trends Genet (TIG)"},{"issue":"6","key":"1176_CR11","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1007\/s12975-020-00806-z","volume":"11","author":"A Datta","year":"2020","unstructured":"Datta A, Sarmah D, Mounica L, Kaur H, Kesharwani R, Verma G, Veeresh P, Kotian V, Kalia K, Borah A et al (2020) Cell death pathways in ischemic stroke and targeted pharmacotherapy. Transl Stroke Res 11(6):1185\u20131202","journal-title":"Transl Stroke Res"},{"key":"1176_CR12","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1080\/21691401.2020.1725533","volume":"48","author":"D Deng","year":"2020","unstructured":"Deng D, Liang H (2020) Silencing MEG3 protects PC12 cells from hypoxic injury by targeting miR-21. Artif Cells Nanomed Biotechnol 48:610\u2013619","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"1176_CR13","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1042\/CS20180411","volume":"132","author":"QW Deng","year":"2018","unstructured":"Deng QW, Li S, Wang H, Sun HL, Zuo L, Gu ZT, Lu G, Sun CZ, Zhang HQ, Yan FL (2018) Differential long noncoding RNA expressions in peripheral blood mononuclear cells for detection of acute ischemic stroke. Clin Sci (lond Engl 1979) 132:1597\u20131614","journal-title":"Clin Sci (lond Engl 1979)"},{"key":"1176_CR14","doi-asserted-by":"publisher","first-page":"4571","DOI":"10.1002\/jcp.29334","volume":"235","author":"W Deng","year":"2020","unstructured":"Deng W, Fan C, Shen R, Wu Y, Du R, Teng J (2020) Long noncoding MIAT acting as a ceRNA to sponge microRNA-204-5p to participate in cerebral microvascular endothelial cell injury after cerebral ischemia through regulating HMGB1. J Cell Physiol 235:4571\u20134586","journal-title":"J Cell Physiol"},{"key":"1176_CR15","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.tig.2014.01.004","volume":"30","author":"S Diederichs","year":"2014","unstructured":"Diederichs S (2014) The four dimensions of noncoding RNA conservation. Trends Genet (TIG) 30:121\u2013123","journal-title":"Trends Genet (TIG)"},{"key":"1176_CR16","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1002\/jnr.24590","volume":"98","author":"C Disdier","year":"2020","unstructured":"Disdier C, Stonestreet BS (2020) Hypoxic-ischemic-related cerebrovascular changes and potential therapeutic strategies in the neonatal brain. J Neurosci Res 98:1468\u20131484","journal-title":"J Neurosci Res"},{"key":"1176_CR17","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1007\/s12264-018-0294-7","volume":"34","author":"Z Dong","year":"2018","unstructured":"Dong Z, Pan K, Pan J, Peng Q, Wang Y (2018) The possibility and molecular mechanisms of cell pyroptosis after cerebral ischemia. Neurosci Bull 34:1131\u20131136","journal-title":"Neurosci Bull"},{"key":"1176_CR18","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nrg3074","volume":"12","author":"M Esteller","year":"2011","unstructured":"Esteller M (2011) Non-coding RNAs in human disease. Nat Rev Genet 12:861\u2013874","journal-title":"Nat Rev Genet"},{"issue":"8","key":"1176_CR19","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1002\/stem.3189","volume":"38","author":"B Fan","year":"2020","unstructured":"Fan B, Pan W, Wang X, Wei M, He A, Zhao A, Chopp M, Zhang ZG, Liu XS (2020) Long noncoding RNA mediates stroke-induced neurogenesis. Stem Cells 38(8):973\u2013985","journal-title":"Stem Cells"},{"key":"1176_CR20","doi-asserted-by":"publisher","first-page":"e196","DOI":"10.1038\/mtna.2014.45","volume":"3","author":"RP Fatemi","year":"2014","unstructured":"Fatemi RP, Velmeshev D, Faghihi MA (2014) De-repressing LncRNA-targeted genes to upregulate gene expression: focus on small molecule therapeutics. Mol Ther Nucleic Acids 3:e196","journal-title":"Mol Ther Nucleic Acids"},{"key":"1176_CR21","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","volume":"6","author":"DN Granger","year":"2015","unstructured":"Granger DN, Kvietys PR (2015) Reperfusion injury and reactive oxygen species: the evolution of a concept. Redox Biol 6:524\u2013551","journal-title":"Redox Biol"},{"key":"1176_CR22","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1159\/000484452","volume":"43","author":"L Han","year":"2017","unstructured":"Han L, Dong Z, Liu N, Xie F, Wang N (2017) Maternally expressed gene 3 (MEG3) enhances PC12 cell hypoxia injury by targeting MiR-147. Cell Physiol Biochem 43:2457\u20132469","journal-title":"Cell Physiol Biochem"},{"key":"1176_CR23","doi-asserted-by":"publisher","first-page":"e1003569","DOI":"10.1371\/journal.pgen.1003569","volume":"9","author":"MJ Hangauer","year":"2013","unstructured":"Hangauer MJ, Vaughn IW, McManus MT (2013) Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet 9:e1003569","journal-title":"PLoS Genet"},{"key":"1176_CR24","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3389\/fmolb.2019.00113","volume":"6","author":"F Hashemian","year":"2019","unstructured":"Hashemian F, Ghafouri-Fard S, Arsang-Jang S, Mirzajani S, Fallah H, Mehvari Habibabadi J, Sayad A, Taheri M (2019) Epilepsy is associated with dysregulation of long non-coding RNAs in the peripheral blood. Front Mol Biosci 6:113","journal-title":"Front Mol Biosci"},{"key":"1176_CR25","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1089\/hum.2017.064","volume":"29","author":"W He","year":"2018","unstructured":"He W, Wei D, Cai D, Chen S, Li S, Chen W (2018) Altered long non-coding RNA transcriptomic profiles in ischemic stroke. Hum Gene Ther 29:719\u2013732","journal-title":"Hum Gene Ther"},{"key":"1176_CR26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3325\/cmj.2019.60.121","volume":"60","author":"V Hribljan","year":"2019","unstructured":"Hribljan V, Lisjak D, Petrovi\u0107 DJ, Mitre\u010di\u0107 D (2019) Necroptosis is one of the modalities of cell death accompanying ischemic brain stroke: from pathogenesis to therapeutic possibilities. Croat Med J 60:121\u2013126","journal-title":"Croat Med J"},{"key":"1176_CR27","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.cell.2019.02.029","volume":"177","author":"DK Jeppesen","year":"2019","unstructured":"Jeppesen DK, Fenix AM, Franklin JL, Higginbotham JN, Zhang Q, Zimmerman LJ, Liebler DC, Ping J, Liu Q, Evans R et al (2019) Reassessment of exosome composition. Cell 177:428-445.e418","journal-title":"Cell"},{"key":"1176_CR28","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.nbd.2011.12.006","volume":"46","author":"R Johnson","year":"2012","unstructured":"Johnson R (2012) Long non-coding RNAs in Huntington\u2019s disease neurodegeneration. Neurobiol Dis 46:245\u2013254","journal-title":"Neurobiol Dis"},{"key":"1176_CR29","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.bbagen.2013.10.035","volume":"1840","author":"P Johnsson","year":"2014","unstructured":"Johnsson P, Lipovich L, Grand\u00e9r D, Morris KV (2014) Evolutionary conservation of long non-coding RNAs; sequence, structure, function. Biochem Biophys Acta 1840:1063\u20131071","journal-title":"Biochem Biophys Acta"},{"key":"1176_CR30","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1126\/science.1138341","volume":"316","author":"P Kapranov","year":"2007","unstructured":"Kapranov P, Cheng J, Dike S, Nix DA, Duttagupta R, Willingham AT, Stadler PF, Hertel J, Hackerm\u00fcller J, Hofacker IL et al (2007) RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science (new York, NY) 316:1484\u20131488","journal-title":"Science (new York, NY)"},{"key":"1176_CR31","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ymthe.2017.10.003","volume":"26","author":"SS Kim","year":"2018","unstructured":"Kim SS, Rait A, Garrido-Sanabria ER, Pirollo KF, Harford JB, Chang EH (2018) Nanotherapeutics for gene modulation that prevents apoptosis in the brain and fatal neuroinflammation. Mol Ther 26:84\u201394","journal-title":"Mol Ther"},{"key":"1176_CR32","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.cell.2018.01.011","volume":"172","author":"F Kopp","year":"2018","unstructured":"Kopp F, Mendell JT (2018) Functional classification and experimental dissection of long noncoding RNAs. Cell 172:393\u2013407","journal-title":"Cell"},{"key":"1176_CR33","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ceb.2014.03.006","volume":"29","author":"MM Kozlov","year":"2014","unstructured":"Kozlov MM, Campelo F, Liska N, Chernomordik LV, Marrink SJ, McMahon HT (2014) Mechanisms shaping cell membranes. Curr Opin Cell Biol 29:53\u201360","journal-title":"Curr Opin Cell Biol"},{"key":"1176_CR34","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.2174\/1568026617666161116144744","volume":"17","author":"MM Kumar","year":"2017","unstructured":"Kumar MM, Goyal R (2017) LncRNA as a therapeutic target for angiogenesis. Curr Top Med Chem 17:1750\u20131757","journal-title":"Curr Top Med Chem"},{"key":"1176_CR35","doi-asserted-by":"publisher","first-page":"113139","DOI":"10.1016\/j.expneurol.2019.113139","volume":"325","author":"J Liang","year":"2020","unstructured":"Liang J, Wang Q, Li JQ, Guo T, Yu D (2020) Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485\/AIM2 axis. Exp Neurol 325:113139","journal-title":"Exp Neurol"},{"key":"1176_CR36","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s13770-019-00190-2","volume":"16","author":"W Lim","year":"2019","unstructured":"Lim W, Kim HS (2019) Exosomes as therapeutic vehicles for cancer. Tissue Eng Regen Med 16:213\u2013223","journal-title":"Tissue Eng Regen Med"},{"key":"1176_CR37","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/978-3-319-42059-2_12","volume":"937","author":"H Ling","year":"2016","unstructured":"Ling H (2016) Non-coding RNAs: therapeutic strategies and delivery systems. Adv Exp Med Biol 937:229\u2013237","journal-title":"Adv Exp Med Biol"},{"key":"1176_CR38","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3389\/fncel.2016.00201","volume":"10","author":"X Liu","year":"2016","unstructured":"Liu X, Hou L, Huang W, Gao Y, Lv X, Tang J (2016) The mechanism of long non-coding RNA MEG3 for neurons apoptosis caused by hypoxia: mediated by miR-181b-12\/15-LOX signaling pathway. Front Cell Neurosci 10:201","journal-title":"Front Cell Neurosci"},{"key":"1176_CR39","doi-asserted-by":"publisher","first-page":"8179","DOI":"10.1007\/s12035-016-0270-z","volume":"54","author":"J Liu","year":"2017","unstructured":"Liu J, Li Q, Zhang KS, Hu B, Niu X, Zhou SM, Li SG, Luo YP, Wang Y, Deng ZF (2017) Downregulation of the long non-coding RNA Meg3 promotes angiogenesis after ischemic brain injury by activating notch signaling. Mol Neurobiol 54:8179\u20138190","journal-title":"Mol Neurobiol"},{"key":"1176_CR40","doi-asserted-by":"publisher","unstructured":"Liu B, Xu T, Meng Y (2020) IncRNA NEAT1 aggravates cerebral ischemia\/reperfusion injury by sponging miR-874-3p. J Biol Regul Homeostatic Agents. https:\/\/doi.org\/10.23812\/20-38A","DOI":"10.23812\/20-38A"},{"key":"1176_CR41","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.4103\/1673-5374.238717","volume":"13","author":"FQ Long","year":"2018","unstructured":"Long FQ, Su QJ, Zhou JX, Wang DS, Li PX, Zeng CS, Cai Y (2018) LncRNA SNHG12 ameliorates brain microvascular endothelial cell injury by targeting miR-199a. Neural Regen Res 13:1919\u20131926","journal-title":"Neural Regen Res"},{"key":"1176_CR42","doi-asserted-by":"publisher","first-page":"7461727","DOI":"10.1155\/2020\/7461727","volume":"2020","author":"Y Lu","year":"2020","unstructured":"Lu Y, Chen L, Li L, Cao Y (2020) Exosomes derived from brain metastatic breast cancer cells destroy the blood-brain barrier by carrying lncRNA GS1-600G8.5. BioMed Res Int 2020:7461727","journal-title":"BioMed Res Int"},{"issue":"41","key":"1176_CR43","doi-asserted-by":"publisher","first-page":"14125","DOI":"10.1074\/jbc.RA119.010946","volume":"295","author":"HC Luo","year":"2020","unstructured":"Luo HC, Yi TZ, Huang FG, Wei Y, Luo XP, Luo QS (2020a) Role of long noncoding RNA MEG3\/MiR-378\/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke. J Biol Chem 295(41):14125\u201314139","journal-title":"J Biol Chem"},{"issue":"9","key":"1176_CR44","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1016\/j.ajpath.2020.05.008","volume":"190","author":"R Luo","year":"2020","unstructured":"Luo R, Jin H, Li L, Hu YX, Xiao F (2020b) Long noncoding RNA MEG3 inhibits apoptosis of retinal pigment epithelium cells induced by high glucose via the miR-93\/Nrf2 axis. Am J Pathol 190(9):1813\u20131822","journal-title":"Am J Pathol"},{"key":"1176_CR45","doi-asserted-by":"publisher","first-page":"R17","DOI":"10.1093\/hmg\/ddl046","volume":"15","author":"JS Mattick","year":"2006","unstructured":"Mattick JS, Makunin IV (2006) Non-coding RNA. Hum Mol Genet 15:R17\u2013R29","journal-title":"Hum Mol Genet"},{"key":"1176_CR46","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/nsmb.2480","volume":"20","author":"TR Mercer","year":"2013","unstructured":"Mercer TR, Mattick JS (2013) Structure and function of long noncoding RNAs in epigenetic regulation. Nat Struct Mol Biol 20:300\u2013307","journal-title":"Nat Struct Mol Biol"},{"key":"1176_CR47","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1046\/j.1365-2443.2000.00320.x","volume":"5","author":"N Miyoshi","year":"2000","unstructured":"Miyoshi N, Wagatsuma H, Wakana S, Shiroishi T, Nomura M, Aisaka K, Kohda T, Surani MA, Kaneko-Ishino T, Ishino F (2000) Identification of an imprinted gene, Meg3\/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. Genes Cells 5:211\u2013220","journal-title":"Genes Cells"},{"key":"1176_CR48","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1136\/neurintsurg-2018-014640","volume":"11","author":"M Mokin","year":"2019","unstructured":"Mokin M, Ansari SA, McTaggart RA, Bulsara KR, Goyal M, Chen M, Fraser JF (2019) Indications for thrombectomy in acute ischemic stroke from emergent large vessel occlusion (ELVO): report of the SNIS Standards and Guidelines Committee. J Neurointervent Surg 11:215\u2013220","journal-title":"J Neurointervent Surg"},{"key":"1176_CR49","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1083\/jcb.200302070","volume":"161","author":"T Nitta","year":"2003","unstructured":"Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S (2003) Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 161:653\u2013660","journal-title":"J Cell Biol"},{"key":"1176_CR50","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12943-018-0812-2","volume":"17","author":"Z Peng","year":"2018","unstructured":"Peng Z, Liu C, Wu M (2018) New insights into long noncoding RNAs and their roles in glioma. Mol Cancer 17:61","journal-title":"Mol Cancer"},{"key":"1176_CR51","doi-asserted-by":"publisher","first-page":"3882","DOI":"10.1242\/dev.140962","volume":"143","author":"RB Perry","year":"2016","unstructured":"Perry RB, Ulitsky I (2016) The functions of long noncoding RNAs in development and stem cells. Development (camb, Engl) 143:3882\u20133894","journal-title":"Development (camb, Engl)"},{"key":"1176_CR52","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nrg3766","volume":"15","author":"J Peters","year":"2014","unstructured":"Peters J (2014) The role of genomic imprinting in biology and disease: an expanding view. Nat Rev Genet 15:517\u2013530","journal-title":"Nat Rev Genet"},{"key":"1176_CR53","doi-asserted-by":"publisher","first-page":"220","DOI":"10.5114\/fn.2019.88450","volume":"57","author":"R Pluta","year":"2019","unstructured":"Pluta R, U\u0142amek-Kozio\u0142 M, Januszewski S, Czuczwar S (2019) Amyloid pathology in the brain after ischemia. Folia Neuropathol 57:220\u2013226","journal-title":"Folia Neuropathol"},{"key":"1176_CR54","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.expneurol.2018.02.013","volume":"304","author":"C Ren","year":"2018","unstructured":"Ren C, Yao Y, Han R, Huang Q, Li H, Wang B, Li S, Li M, Mao Y, Mao X et al (2018) Cerebral ischemia induces angiogenesis in the peri-infarct regions via Notch1 signaling activation. Exp Neurol 304:30\u201340","journal-title":"Exp Neurol"},{"key":"1176_CR55","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ygeno.2011.05.003","volume":"98","author":"S Sato","year":"2011","unstructured":"Sato S, Yoshida W, Soejima H, Nakabayashi K, Hata K (2011) Methylation dynamics of IG-DMR and Gtl2-DMR during murine embryonic and placental development. Genomics 98:120\u2013127","journal-title":"Genomics"},{"key":"1176_CR56","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3389\/fneur.2015.00050","volume":"6","author":"JA Saugstad","year":"2015","unstructured":"Saugstad JA (2015) Non-coding RNAs in stroke and neuroprotection. Front Neurol 6:50","journal-title":"Front Neurol"},{"issue":"6","key":"1176_CR57","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3390\/jcm5060056","volume":"5","author":"SW Seto","year":"2016","unstructured":"Seto SW, Chang D, Jenkins A, Bensoussan A, Kiat H (2016) Angiogenesis in ischemic stroke and angiogenic effects of Chinese herbal medicine. J Clin Med 5(6):5","journal-title":"J Clin Med"},{"key":"1176_CR58","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/jcmm.14712","volume":"24","author":"W Shan","year":"2020","unstructured":"Shan W, Chen W, Zhao X, Pei A, Chen M, Yu Y, Zheng Y, Zhu S (2020) Long noncoding RNA TUG1 contributes to cerebral ischaemia\/reperfusion injury by sponging mir-145 to up-regulate AQP4 expression. J Cell Mol Med 24:250\u2013259","journal-title":"J Cell Mol Med"},{"key":"1176_CR59","first-page":"4341","volume":"23","author":"HF Shao","year":"2019","unstructured":"Shao HF, Li ZZ, Zheng XF, Wang HJ, Wang YG, Ma ZL, Liu ZB, Han QY (2019) Research on the correlation of changes in plasma lncRNA MEG3 with change in inflammatory factors and prognosis in patients with traumatic brain injury. Eur Rev Med Pharmacol Sci 23:4341\u20134347","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1176_CR60","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1080\/21691401.2018.1471483","volume":"46","author":"J Shen","year":"2018","unstructured":"Shen J, Zhao Z, Shang W, Liu C, Zhang B, Xu Z, Cai H (2018) Fabrication of a nano polymer wrapping Meg3 ShRNA plasmid for the treatment of cerebral infarction. Artif Cells Nanomed Biotechnol 46:894\u2013903","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"1176_CR61","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1007\/s11481-019-09873-y","volume":"15","author":"S Sil","year":"2019","unstructured":"Sil S, Dagur RS, Liao K, Peeples ES, Hu G, Periyasamy P, Buch S (2019) Strategies for the use of extracellular vesicles for the delivery of therapeutics. J Neuroimmune Pharmacol 15:422\u2013442","journal-title":"J Neuroimmune Pharmacol"},{"key":"1176_CR62","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1161\/STROKEAHA.115.010863","volume":"47","author":"WS Smith","year":"2016","unstructured":"Smith WS, Furlan AJ (2016) Brief history of endovascular acute ischemic stroke treatment. Stroke 47:e23-26","journal-title":"Stroke"},{"key":"1176_CR63","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41582-019-0221-1","volume":"15","author":"G Stoll","year":"2019","unstructured":"Stoll G, Nieswandt B (2019) Thrombo-inflammation in acute ischaemic stroke - implications for treatment. Nat Rev Neurol 15:473\u2013481","journal-title":"Nat Rev Neurol"},{"key":"1176_CR64","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3389\/fncel.2017.00124","volume":"11","author":"MC Tan","year":"2017","unstructured":"Tan MC, Widagdo J, Chau YQ, Zhu T, Wong JJ, Cheung A, Anggono V (2017) The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons. Front Cell Neurosci 11:124","journal-title":"Front Cell Neurosci"},{"key":"1176_CR65","doi-asserted-by":"publisher","first-page":"101042831769757","DOI":"10.1177\/1010428317697578","volume":"39","author":"H Tian","year":"2017","unstructured":"Tian H, Zhou C, Yang J, Li J, Gong Z (2017) Long and short noncoding RNAs in lung cancer precision medicine: opportunities and challenges. Tumour Biol 39:1010428317697578","journal-title":"Tumour Biol"},{"key":"1176_CR66","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1002\/path.5405","volume":"250","author":"I Tsagakis","year":"2020","unstructured":"Tsagakis I, Douka K, Birds I, Aspden JL (2020) Long non-coding RNAs in development and disease: conservation to mechanisms. J Pathol 250:480\u2013495","journal-title":"J Pathol"},{"key":"1176_CR67","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.cell.2011.11.055","volume":"147","author":"I Ulitsky","year":"2011","unstructured":"Ulitsky I, Shkumatava A, Jan CH, Sive H, Bartel DP (2011) Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution. Cell 147:1537\u20131550","journal-title":"Cell"},{"key":"1176_CR68","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.molcel.2011.08.018","volume":"43","author":"KC Wang","year":"2011","unstructured":"Wang KC, Chang HY (2011) Molecular mechanisms of long noncoding RNAs. Mol Cell 43:904\u2013914","journal-title":"Mol Cell"},{"key":"1176_CR69","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.2174\/1381612825666190328112844","volume":"25","author":"Q Wang","year":"2019","unstructured":"Wang Q, Liu X, Zhu R (2019) Long noncoding RNAs as diagnostic and therapeutic targets for ischemic stroke. Curr Pharm Des 25:1115\u20131121","journal-title":"Curr Pharm Des"},{"key":"1176_CR70","doi-asserted-by":"publisher","first-page":"718","DOI":"10.5551\/jat.50674","volume":"27","author":"M Wang","year":"2020","unstructured":"Wang M, Chen W, Geng Y, Xu C, Tao X, Zhang Y (2020) Long non-coding RNA MEG3 promotes apoptosis of vascular cells and is associated with poor prognosis in ischemic stroke. J Atheroscler Thromb 27:718\u2013726","journal-title":"J Atheroscler Thromb"},{"key":"1176_CR71","doi-asserted-by":"publisher","first-page":"7686","DOI":"10.1007\/s12035-016-0354-9","volume":"54","author":"Z Wu","year":"2017","unstructured":"Wu Z, Wu P, Zuo X, Yu N, Qin Y, Xu Q, He S, Cen B, Liao W, Ji A (2017) Erratum to: LncRNA-N1LR enhances neuroprotection against ischemic stroke probably by inhibiting p53 phosphorylation. Mol Neurobiol 54:7686\u20137688","journal-title":"Mol Neurobiol"},{"key":"1176_CR72","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1101\/gr.161600","volume":"10","author":"AA Wylie","year":"2000","unstructured":"Wylie AA, Murphy SK, Orton TC, Jirtle RL (2000) Novel imprinted DLK1\/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2\/H19 regulation. Genome Res 10:1711\u20131718","journal-title":"Genome Res"},{"key":"1176_CR73","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.18632\/aging.102790","volume":"12","author":"Y Xiang","year":"2020","unstructured":"Xiang Y, Zhang Y, Xia Y, Zhao H, Liu A, Chen Y (2020) LncRNA MEG3 targeting miR-424-5p via MAPK signaling pathway mediates neuronal apoptosis in ischemic stroke. Aging 12:3156\u20133174","journal-title":"Aging"},{"key":"1176_CR74","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1177\/0963689718773361","volume":"27","author":"W Xu","year":"2018","unstructured":"Xu W, Gao L, Zheng J, Li T, Shao A, Reis C, Chen S, Zhang J (2018) The roles of MicroRNAs in stroke: possible therapeutic targets. Cell Transplant 27:1778\u20131788","journal-title":"Cell Transplant"},{"key":"1176_CR75","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neuroscience.2016.09.017","volume":"337","author":"H Yan","year":"2016","unstructured":"Yan H, Yuan J, Gao L, Rao J, Hu J (2016) Long noncoding RNA MEG3 activation of p53 mediates ischemic neuronal death in stroke. Neuroscience 337:191\u2013199","journal-title":"Neuroscience"},{"key":"1176_CR76","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1038\/s41419-017-0047-y","volume":"8","author":"H Yan","year":"2017","unstructured":"Yan H, Rao J, Yuan J, Gao L, Huang W, Zhao L, Ren J (2017) Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21\/PDCD4 signaling pathway. Cell Death Dis 8:3211","journal-title":"Cell Death Dis"},{"key":"1176_CR77","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.mvr.2018.12.005","volume":"123","author":"J Yang","year":"2019","unstructured":"Yang J (2019) The role of reactive oxygen species in angiogenesis and preventing tissue injury after brain ischemia. Microvasc Res 123:62\u201367","journal-title":"Microvasc Res"},{"key":"1176_CR78","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/978-981-13-1426-1_25","volume":"1087","author":"J Yang","year":"2018","unstructured":"Yang J, Chen M, Cao RY, Li Q, Zhu F (2018) The role of circular RNAs in cerebral ischemic diseases: ischemic stroke and cerebral ischemia\/reperfusion injury. Adv Exp Med Biol 1087:309\u2013325","journal-title":"Adv Exp Med Biol"},{"key":"1176_CR79","doi-asserted-by":"publisher","first-page":"144411","DOI":"10.1016\/j.gene.2020.144411","volume":"737","author":"P Yao","year":"2020","unstructured":"Yao P, Li YL, Chen Y, Shen W, Wu KY, Xu WH (2020) Overexpression of long non-coding RNA Rian attenuates cell apoptosis from cerebral ischemia-reperfusion injury via Rian\/miR-144-3p\/GATA3 signaling. Gene 737:144411","journal-title":"Gene"},{"key":"1176_CR80","doi-asserted-by":"publisher","first-page":"352","DOI":"10.2174\/15701611113119990016","volume":"13","author":"KJ Yin","year":"2015","unstructured":"Yin KJ, Hamblin M, Chen YE (2015) Angiogenesis-regulating microRNAs and ischemic stroke. Curr Vasc Pharmacol 13:352\u2013365","journal-title":"Curr Vasc Pharmacol"},{"key":"1176_CR81","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/j.biopha.2018.12.067","volume":"111","author":"D You","year":"2019","unstructured":"You D, You H (2019) Repression of long non-coding RNA MEG3 restores nerve growth and alleviates neurological impairment after cerebral ischemia-reperfusion injury in a rat model. Biomed Pharmacother 111:1447\u20131457","journal-title":"Biomed Pharmacother"},{"key":"1176_CR82","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.hlc.2017.09.011","volume":"27","author":"SY Yu","year":"2018","unstructured":"Yu SY, Tang L, Zhou SH (2018) Long noncoding RNAs: new players in ischaemia-reperfusion injury. Heart Lung Circ 27:322\u2013332","journal-title":"Heart Lung Circ"},{"key":"1176_CR83","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jconrel.2018.05.010","volume":"283","author":"S Zeniya","year":"2018","unstructured":"Zeniya S, Kuwahara H, Daizo K, Watari A, Kondoh M, Yoshida-Tanaka K, Kaburagi H, Asada K, Nagata T, Nagahama M et al (2018) Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system. J Control Release 283:126\u2013134","journal-title":"J Control Release"},{"key":"1176_CR84","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.bbrc.2017.06.104","volume":"490","author":"R Zhan","year":"2017","unstructured":"Zhan R, Xu K, Pan J, Xu Q, Xu S, Shen J (2017) Long noncoding RNA MEG3 mediated angiogenesis after cerebral infarction through regulating p53\/NOX4 axis. Biochem Biophys Res Commun 490:700\u2013706","journal-title":"Biochem Biophys Res Commun"},{"key":"1176_CR85","doi-asserted-by":"publisher","first-page":"5119","DOI":"10.1210\/jc.2003-030222","volume":"88","author":"X Zhang","year":"2003","unstructured":"Zhang X, Zhou Y, Mehta KR, Danila DC, Scolavino S, Johnson SR, Klibanski A (2003) A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells. J Clin Endocrinol Metab 88:5119\u20135126","journal-title":"J Clin Endocrinol Metab"},{"key":"1176_CR86","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1158\/0008-5472.CAN-09-3885","volume":"70","author":"X Zhang","year":"2010","unstructured":"Zhang X, Gejman R, Mahta A, Zhong Y, Rice KA, Zhou Y, Cheunsuchon P, Louis DN, Klibanski A (2010) Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression. Cancer Res 70:2350\u20132358","journal-title":"Cancer Res"},{"key":"1176_CR87","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.expneurol.2015.12.014","volume":"277","author":"J Zhang","year":"2016","unstructured":"Zhang J, Yuan L, Zhang X, Hamblin MH, Zhu T, Meng F, Li Y, Chen YE, Yin KJ (2016) Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia. Exp Neurol 277:162\u2013170","journal-title":"Exp Neurol"},{"issue":"6","key":"1176_CR88","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.3390\/ijms19061723","volume":"19","author":"X Zhang","year":"2018","unstructured":"Zhang X, Tang X, Hamblin MH, Yin KJ (2018) Long non-coding RNA Malat1 regulates angiogenesis in hindlimb ischemia. Int J Mol Sci 19(6):1723","journal-title":"Int J Mol Sci"},{"key":"1176_CR89","first-page":"3282","volume":"17","author":"WF Zhang","year":"2019","unstructured":"Zhang WF, Jin YC, Li XM, Yang Z, Wang D, Cui JJ (2019a) Protective effects of leptin against cerebral ischemia\/reperfusion injury. Exp Ther Med 17:3282\u20133290","journal-title":"Exp Ther Med"},{"key":"1176_CR90","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12974-019-1464-x","volume":"16","author":"X Zhang","year":"2019","unstructured":"Zhang X, Zhu XL, Ji BY, Cao X, Yu LJ, Zhang Y, Bao XY, Xu Y, Jin JL (2019b) LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke. J Neuroinflammation 16:75","journal-title":"J Neuroinflammation"},{"key":"1176_CR91","doi-asserted-by":"publisher","first-page":"353","DOI":"10.14336\/AD.2018.0617","volume":"10","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Zhang L, Wang Y, Ding H, Xue S, Qi H, Li P (2019c) MicroRNAs or long noncoding RNAs in diagnosis and prognosis of coronary artery disease. Aging Dis 10:353\u2013366","journal-title":"Aging Dis"},{"key":"1176_CR92","doi-asserted-by":"publisher","first-page":"13850","DOI":"10.1038\/srep13850","volume":"5","author":"F Zhao","year":"2015","unstructured":"Zhao F, Qu Y, Liu J, Liu H, Zhang L, Feng Y, Wang H, Gan J, Lu R, Mu D (2015) Microarray profiling and co-expression network analysis of LncRNAs and mRNAs in neonatal rats following hypoxic-ischemic brain damage. Sci Rep 5:13850","journal-title":"Sci Rep"},{"key":"1176_CR93","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.14336\/AD.2018.1105","volume":"10","author":"Y Zhao","year":"2019","unstructured":"Zhao Y, Zhang Y, Zhang L, Dong Y, Ji H, Shen L (2019) The potential markers of circulating microRNAs and long non-coding RNAs in Alzheimer\u2019s disease. Aging Dis 10:1293\u20131301","journal-title":"Aging Dis"},{"key":"1176_CR94","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.bbrc.2021.06.033","volume":"568","author":"F Zhao","year":"2021","unstructured":"Zhao F, Xing Y, Jiang P, Hu L, Deng S (2021) LncRNA MEG3 inhibits the proliferation of neural stem cells after ischemic stroke via the miR-493-5P\/MIF axis. Biochem Biophys Res Commun 568:186\u2013192","journal-title":"Biochem Biophys Res Commun"},{"key":"1176_CR95","doi-asserted-by":"publisher","first-page":"3535","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.08.016","volume":"27","author":"Z Zheng","year":"2018","unstructured":"Zheng Z, Liu S, Wang C, Han X (2018) A functional polymorphism rs145204276 in the promoter of long noncoding RNA GAS5 is associated with an increased risk of ischemic stroke. J Stroke Cerebrovasc Dis 27:3535\u20133541","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"1176_CR96","first-page":"4951692","volume":"2020","author":"H Zheng","year":"2020","unstructured":"Zheng H, Li BH, Liu C, Jia L, Liu FT (2020) Comprehensive analysis of lncRNA-mediated ceRNA crosstalk and identification of prognostic biomarkers in Wilms\u2019 tumor. Biomed Res Int 2020:4951692","journal-title":"Biomed Res Int"},{"key":"1176_CR97","doi-asserted-by":"publisher","first-page":"R45","DOI":"10.1530\/JME-12-0008","volume":"48","author":"Y Zhou","year":"2012","unstructured":"Zhou Y, Zhang X, Klibanski A (2012) MEG3 noncoding RNA: a tumor suppressor. J Mol Endocrinol 48:R45-53","journal-title":"J Mol Endocrinol"},{"key":"1176_CR98","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12943-018-0823-z","volume":"17","author":"R Zhou","year":"2018","unstructured":"Zhou R, Chen KK, Zhang J, Xiao B, Huang Z, Ju C, Sun J, Zhang F, Lv XB, Huang G (2018a) The decade of exosomal long RNA species: an emerging cancer antagonist. Mol Cancer 17:75","journal-title":"Mol Cancer"},{"key":"1176_CR99","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28075","author":"XM Zhou","year":"2018","unstructured":"Zhou XM, Liu J, Wang Y, Zhang MH (2018b) Silencing of long noncoding RNA MEG3 enhances cerebral protection of dexmedetomidine against hypoxic-ischemic brain damage in neonatal mice by binding to miR-129-5p. J Cell Biochem. https:\/\/doi.org\/10.1002\/jcb.28075","journal-title":"J Cell Biochem"},{"key":"1176_CR100","doi-asserted-by":"publisher","first-page":"7159592","DOI":"10.1155\/2019\/7159592","volume":"2019","author":"H Zhou","year":"2019","unstructured":"Zhou H, Wang B, Yang YX, Jia QJ, Zhang A, Qi ZW, Zhang JP (2019a) Long noncoding RNAs in pathological cardiac remodeling: a review of the update literature. Biomed Res Int 2019:7159592","journal-title":"Biomed Res Int"},{"key":"1176_CR101","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.brainres.2018.10.031","volume":"1707","author":"ZW Zhou","year":"2019","unstructured":"Zhou ZW, Zheng LJ, Ren X, Li AP, Zhou WS (2019b) LncRNA NEAT1 facilitates survival and angiogenesis in oxygen-glucose deprivation (OGD)-induced brain microvascular endothelial cells (BMECs) via targeting miR-377 and upregulating SIRT1, VEGFA, and BCL-XL. Brain Res 1707:90\u201398","journal-title":"Brain Res"},{"key":"1176_CR102","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1007\/s11011-021-00725-4","volume":"36","author":"R Zhu","year":"2021","unstructured":"Zhu R, Xiao T, Wang Q, Zhao Y, Liu X (2021) Genetic polymorphisms in lncRNAs predict recurrence of ischemic stroke. Metab Brain Dis 36:1353\u20131359","journal-title":"Metab Brain Dis"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-021-01176-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10571-021-01176-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-021-01176-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T17:39:45Z","timestamp":1672853985000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10571-021-01176-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,6]]},"references-count":102,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["1176"],"URL":"https:\/\/doi.org\/10.1007\/s10571-021-01176-2","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,6]]},"assertion":[{"value":"16 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declared that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}