{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:36:02Z","timestamp":1792575362619,"version":"4.5.0"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2020CFB240"],"award-info":[{"award-number":["2020CFB240"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2042020kf0065"],"award-info":[{"award-number":["2042020kf0065"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1007\/s10571-022-01210-x","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T11:03:13Z","timestamp":1646046193000},"page":"561-574","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Long Non-Coding RNAs in Retinal Ganglion Cell Apoptosis"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9570-4726","authenticated-orcid":false,"given":"Ningzhi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1781-0555","authenticated-orcid":false,"given":"Wenye","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7183-4860","authenticated-orcid":false,"given":"Xuejun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4482-3319","authenticated-orcid":false,"given":"Yiqiao","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3036-0202","authenticated-orcid":false,"given":"Ning","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"1210_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094672","author":"S Al Hussein Al Awamlh","year":"2021","unstructured":"Al Hussein Al Awamlh S, Wareham LK, Risner ML, Calkins DJ (2021) Insulin signaling as a therapeutic target in glaucomatous neurodegeneration. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22094672","journal-title":"Int J Mol Sci"},{"key":"1210_CR2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.60583","author":"T Ali","year":"2020","unstructured":"Ali T, Grote P (2020) Beyond the RNA-dependent function of LncRNA genes. Elife. https:\/\/doi.org\/10.7554\/eLife.60583","journal-title":"Elife"},{"key":"1210_CR3","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","volume":"31","author":"M Almasieh","year":"2012","unstructured":"Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A (2012) The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res 31:152\u2013181. https:\/\/doi.org\/10.1016\/j.preteyeres.2011.11.002","journal-title":"Prog Retin Eye Res"},{"key":"1210_CR4","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1186\/s12864-021-08050-x","volume":"22","author":"AC Ayupe","year":"2021","unstructured":"Ayupe AC, Beckedorff F, Levay K et al (2021) Identification of long noncoding RNAs in injury-resilient and injury-susceptible mouse retinal ganglion cells. BMC Genom 22:741. https:\/\/doi.org\/10.1186\/s12864-021-08050-x","journal-title":"BMC Genom"},{"key":"1210_CR5","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1016\/j.biopha.2018.11.024","volume":"109","author":"H Bao","year":"2019","unstructured":"Bao H, Sun D, Qi P, Jiang S (2019) Astragaloside protects oxygen and glucose deprivation induced injury by regulation of microRNA-21 in retinal ganglion cell line RGC-5. Biomed Pharmacother 109:1826\u20131833. https:\/\/doi.org\/10.1016\/j.biopha.2018.11.024","journal-title":"Biomed Pharmacother"},{"key":"1210_CR6","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1152\/physrev.00041.2015","volume":"96","author":"J Beermann","year":"2016","unstructured":"Beermann J, Piccoli MT, Viereck J, Thum T (2016) Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches. Physiol Rev 96:1297\u20131325. https:\/\/doi.org\/10.1152\/physrev.00041.2015","journal-title":"Physiol Rev"},{"key":"1210_CR7","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1002\/cmdc.201300534","volume":"9","author":"A Bhan","year":"2014","unstructured":"Bhan A, Mandal SS (2014) Long noncoding RNAs: emerging stars in gene regulation, epigenetics and human disease. ChemMedChem 9:1932\u20131956. https:\/\/doi.org\/10.1002\/cmdc.201300534","journal-title":"ChemMedChem"},{"key":"1210_CR8","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202009045","author":"MC Bridges","year":"2021","unstructured":"Bridges MC, Daulagala AC, Kourtidis A (2021) LNCcation: lncRNA localization and function. J Cell Biol. https:\/\/doi.org\/10.1083\/jcb.202009045","journal-title":"J Cell Biol"},{"key":"1210_CR9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.nbd.2010.02.003","volume":"39","author":"NJ Buckley","year":"2010","unstructured":"Buckley NJ, Johnson R, Zuccato C, Bithell A, Cattaneo E (2010) The role of REST in transcriptional and epigenetic dysregulation in Huntington\u2019s disease. Neurobiol Dis 39:28\u201339. https:\/\/doi.org\/10.1016\/j.nbd.2010.02.003","journal-title":"Neurobiol Dis"},{"key":"1210_CR10","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1016\/j.ophtha.2012.02.004","volume":"119","author":"KP Burdon","year":"2012","unstructured":"Burdon KP, Crawford A, Casson RJ et al (2012) Glaucoma risk alleles at CDKN2B-AS1 are associated with lower intraocular pressure, normal-tension glaucoma, and advanced glaucoma. Ophthalmology 119:1539\u20131545. https:\/\/doi.org\/10.1016\/j.ophtha.2012.02.004","journal-title":"Ophthalmology"},{"key":"1210_CR11","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s13041-020-00656-8","volume":"13","author":"LJ Cai","year":"2020","unstructured":"Cai LJ, Tu L, Huang XM et al (2020) LncRNA MALAT1 facilitates inflammasome activation via epigenetic suppression of Nrf2 in Parkinson\u2019s disease. Mol Brain 13:130. https:\/\/doi.org\/10.1186\/s13041-020-00656-8","journal-title":"Mol Brain"},{"key":"1210_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109249","volume":"331","author":"HY Chen","year":"2020","unstructured":"Chen HY, Ho YJ, Chou HC et al (2020) TGF-\u03b21 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1\/Nrf2 pathway. Chem Biol Interact 331:109249. https:\/\/doi.org\/10.1016\/j.cbi.2020.109249","journal-title":"Chem Biol Interact"},{"key":"1210_CR13","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.2174\/1570159x16666180419121247","volume":"16","author":"N Chitranshi","year":"2018","unstructured":"Chitranshi N, Dheer Y, Abbasi M et al (2018) Glaucoma pathogenesis and neurotrophins: focus on the molecular and genetic basis for therapeutic prospects. Curr Neuropharmacol 16:1018\u20131035. https:\/\/doi.org\/10.2174\/1570159x16666180419121247","journal-title":"Curr Neuropharmacol"},{"key":"1210_CR14","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1517\/14712598.2016.1114096","volume":"16","author":"CJ Choong","year":"2016","unstructured":"Choong CJ, Baba K, Mochizuki H (2016) Gene therapy for neurological disorders. Expert Opin Biol Ther 16:143\u2013159. https:\/\/doi.org\/10.1517\/14712598.2016.1114096","journal-title":"Expert Opin Biol Ther"},{"key":"1210_CR15","doi-asserted-by":"publisher","first-page":"e000131","DOI":"10.1136\/bmjophth-2017-000131","volume":"3","author":"Y Ciss\u00e9","year":"2018","unstructured":"Ciss\u00e9 Y, Bai L, Meng T (2018) LncRNAs in genetic basis of glaucoma. BMJ Open Ophthalmol 3:e000131. https:\/\/doi.org\/10.1136\/bmjophth-2017-000131","journal-title":"BMJ Open Ophthalmol"},{"key":"1210_CR16","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.25607","author":"MJ Del\u00e1s","year":"2017","unstructured":"Del\u00e1s MJ, Sabin LR, Dolzhenko E et al (2017) lncRNA requirements for mouse acute myeloid leukemia and normal differentiation. Elife. https:\/\/doi.org\/10.7554\/eLife.25607","journal-title":"Elife"},{"key":"1210_CR17","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature11233","volume":"489","author":"S Djebali","year":"2012","unstructured":"Djebali S, Davis CA, Merkel A et al (2012) Landscape of transcription in human cells. Nature 489:101\u2013108. https:\/\/doi.org\/10.1038\/nature11233","journal-title":"Nature"},{"key":"1210_CR18","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.gpb.2016.12.005","volume":"15","author":"IM Dykes","year":"2017","unstructured":"Dykes IM, Emanueli C (2017) Transcriptional and post-transcriptional gene regulation by long non-coding RNA. Genom Proteomics Bioinform 15:177\u2013186. https:\/\/doi.org\/10.1016\/j.gpb.2016.12.005","journal-title":"Genom Proteomics Bioinform"},{"key":"1210_CR19","doi-asserted-by":"publisher","first-page":"100942","DOI":"10.1016\/j.arr.2019.100942","volume":"54","author":"L F\u00e3o","year":"2019","unstructured":"F\u00e3o L, Mota SI, Rego AC (2019) Shaping the Nrf2-ARE-related pathways in Alzheimer\u2019s and Parkinson\u2019s diseases. Ageing Res Rev 54:100942. https:\/\/doi.org\/10.1016\/j.arr.2019.100942","journal-title":"Ageing Res Rev"},{"key":"1210_CR20","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1152\/physrev.00011.2017","volume":"98","author":"M Fricker","year":"2018","unstructured":"Fricker M, Tolkovsky AM, Borutaite V, Coleman M, Brown GC (2018) Neuronal cell death. Physiol Rev 98:813\u2013880. https:\/\/doi.org\/10.1152\/physrev.00011.2017","journal-title":"Physiol Rev"},{"key":"1210_CR21","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.ajpath.2015.11.026","volume":"186","author":"S Gao","year":"2016","unstructured":"Gao S, Jakobs TC (2016) Mice homozygous for a deletion in the glaucoma susceptibility locus INK4 show increased vulnerability of retinal ganglion cells to elevated intraocular pressure. Am J Pathol 186:985\u20131005. https:\/\/doi.org\/10.1016\/j.ajpath.2015.11.026","journal-title":"Am J Pathol"},{"key":"1210_CR22","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.omtn.2020.01.011","volume":"19","author":"Y Ge","year":"2020","unstructured":"Ge Y, Zhang R, Feng Y, Li H (2020) Mbd2 mediates retinal cell apoptosis by targeting the lncRNA Mbd2-AL1\/miR-188-3p\/Traf3 axis in Ischemia\/reperfusion injury. Mol Ther Nucleic Acids 19:1250\u20131265. https:\/\/doi.org\/10.1016\/j.omtn.2020.01.011","journal-title":"Mol Ther Nucleic Acids"},{"key":"1210_CR23","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1038\/ng.3079","volume":"46","author":"P Gharahkhani","year":"2014","unstructured":"Gharahkhani P, Burdon KP, Fogarty R et al (2014) Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma. Nat Genet 46:1120\u20131125. https:\/\/doi.org\/10.1038\/ng.3079","journal-title":"Nat Genet"},{"key":"1210_CR24","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1080\/15384101.2019.1612697","volume":"18","author":"W Gong","year":"2019","unstructured":"Gong W, Li J, Zhu G et al (2019) Chlorogenic acid relieved oxidative stress injury in retinal ganglion cells through IncRNA-TUG1\/Nrf2. Cell Cycle 18:1549\u20131559. https:\/\/doi.org\/10.1080\/15384101.2019.1612697","journal-title":"Cell Cycle"},{"key":"1210_CR25","doi-asserted-by":"publisher","first-page":"e2000027","DOI":"10.1002\/bies.202000027","volume":"42","author":"J Graf","year":"2020","unstructured":"Graf J, Kretz M (2020) From structure to function: route to understanding lncRNA mechanism. BioEssays 42:e2000027. https:\/\/doi.org\/10.1002\/bies.202000027","journal-title":"BioEssays"},{"key":"1210_CR26","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/imr.12285","volume":"265","author":"M Haneklaus","year":"2015","unstructured":"Haneklaus M, O\u2019Neill LA (2015) NLRP3 at the interface of metabolism and inflammation. Immunol Rev 265:53\u201362. https:\/\/doi.org\/10.1111\/imr.12285","journal-title":"Immunol Rev"},{"key":"1210_CR27","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1111\/j.1440-169X.2011.01303.x","volume":"54","author":"JY Ip","year":"2012","unstructured":"Ip JY, Nakagawa S (2012) Long non-coding RNAs in nuclear bodies. Dev Growth Differ 54:44\u201354. https:\/\/doi.org\/10.1111\/j.1440-169X.2011.01303.x","journal-title":"Dev Growth Differ"},{"key":"1210_CR28","doi-asserted-by":"publisher","first-page":"49688","DOI":"10.18632\/oncotarget.10434","volume":"7","author":"Q Jiang","year":"2016","unstructured":"Jiang Q, Shan K, Qun-Wang X et al (2016) Long non-coding RNA-MIAT promotes neurovascular remodeling in the eye and brain. Oncotarget 7:49688\u201349698. https:\/\/doi.org\/10.18632\/oncotarget.10434","journal-title":"Oncotarget"},{"key":"1210_CR29","first-page":"5590","volume":"58","author":"WM Johnson","year":"2017","unstructured":"Johnson WM, Aboobakar IF, Finnegan L et al (2017) Identification of the hnRNPL and LOXL1-AS1 lncRNA complex: Implications for pathology in exfoliation glaucoma. Investig Ophthalmol Vis Sci 58:5590","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1210_CR30","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/nature09033","volume":"465","author":"TK Kim","year":"2010","unstructured":"Kim TK, Hemberg M, Gray JM et al (2010) Widespread transcription at neuronal activity-regulated enhancers. Nature 465:182\u2013187. https:\/\/doi.org\/10.1038\/nature09033","journal-title":"Nature"},{"key":"1210_CR31","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.cell.2018.01.011","volume":"172","author":"F Kopp","year":"2018","unstructured":"Kopp F, Mendell JT (2018) Functional classification and experimental dissection of long noncoding RNAs. Cell 172:393\u2013407. https:\/\/doi.org\/10.1016\/j.cell.2018.01.011","journal-title":"Cell"},{"key":"1210_CR32","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.pharmthera.2005.03.004","volume":"107","author":"RK Leung","year":"2005","unstructured":"Leung RK, Whittaker PA (2005) RNA interference: from gene silencing to gene-specific therapeutics. Pharmacol Ther 107:222\u2013239. https:\/\/doi.org\/10.1016\/j.pharmthera.2005.03.004","journal-title":"Pharmacol Ther"},{"key":"1210_CR33","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s10571-016-0380-1","volume":"37","author":"CP Li","year":"2017","unstructured":"Li CP, Wang SH, Wang WQ, Song SG, Liu XM (2017a) Long noncoding RNA-Sox2OT knockdown alleviates diabetes mellitus-induced retinal ganglion cell (RGC) injury. Cell Mol Neurobiol 37:361\u2013369. https:\/\/doi.org\/10.1007\/s10571-016-0380-1","journal-title":"Cell Mol Neurobiol"},{"key":"1210_CR34","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.3892\/mmr.2017.6722","volume":"16","author":"Y Li","year":"2017","unstructured":"Li Y, Jin L, Dong A, Zhou X, Yuan H (2017b) Microarray expression profile analysis of long non-coding RNAs in optineurin E50K mutant transgenic mice. Mol Med Rep 16:1255\u20131261. https:\/\/doi.org\/10.3892\/mmr.2017.6722","journal-title":"Mol Med Rep"},{"key":"1210_CR35","doi-asserted-by":"publisher","first-page":"630","DOI":"10.3109\/07388551.2014.1003030","volume":"36","author":"Y Liao","year":"2016","unstructured":"Liao Y, Tang L (2016) Inducible RNAi system and its application in novel therapeutics. Crit Rev Biotechnol 36:630\u2013638. https:\/\/doi.org\/10.3109\/07388551.2014.1003030","journal-title":"Crit Rev Biotechnol"},{"key":"1210_CR36","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nature05292","volume":"443","author":"MT Lin","year":"2006","unstructured":"Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787\u2013795. https:\/\/doi.org\/10.1038\/nature05292","journal-title":"Nature"},{"key":"1210_CR37","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1111\/jcmm.14163","volume":"23","author":"H Liu","year":"2019","unstructured":"Liu H, Xu D, Zhong X et al (2019) LncRNA-mRNA competing endogenous RNA network depicts transcriptional regulation in ischaemia reperfusion injury. J Cell Mol Med 23:2272\u20132276. https:\/\/doi.org\/10.1111\/jcmm.14163","journal-title":"J Cell Mol Med"},{"key":"1210_CR38","doi-asserted-by":"publisher","first-page":"107955","DOI":"10.1016\/j.exer.2020.107955","volume":"193","author":"YF Liu","year":"2020","unstructured":"Liu YF, Huang S, Ng TK et al (2020) Longitudinal evaluation of immediate inflammatory responses after intravitreal AAV2 injection in rats by optical coherence tomography. Exp Eye Res 193:107955. https:\/\/doi.org\/10.1016\/j.exer.2020.107955","journal-title":"Exp Eye Res"},{"key":"1210_CR39","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41586-020-2975-4","volume":"588","author":"Y Lu","year":"2020","unstructured":"Lu Y, Brommer B, Tian X et al (2020) Reprogramming to recover youthful epigenetic information and restore vision. Nature 588:124\u2013129. https:\/\/doi.org\/10.1038\/s41586-020-2975-4","journal-title":"Nature"},{"key":"1210_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.01.002","volume":"57","author":"ME Maes","year":"2017","unstructured":"Maes ME, Schlamp CL, Nickells RW (2017) BAX to basics: how the BCL2 gene family controls the death of retinal ganglion cells. Prog Retin Eye Res 57:1\u201325. https:\/\/doi.org\/10.1016\/j.preteyeres.2017.01.002","journal-title":"Prog Retin Eye Res"},{"key":"1210_CR41","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature11928","volume":"495","author":"S Memczak","year":"2013","unstructured":"Memczak S, Jens M, Elefsinioti A et al (2013) Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 495:333\u2013338. https:\/\/doi.org\/10.1038\/nature11928","journal-title":"Nature"},{"key":"1210_CR42","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1002\/ajmg.c.31833","volume":"184","author":"H Moazzeni","year":"2020","unstructured":"Moazzeni H, Khani M, Elahi E (2020) Insights into the regulatory molecules involved in glaucoma pathogenesis. Am J Med Genet C Semin Med Genet 184:782\u2013827. https:\/\/doi.org\/10.1002\/ajmg.c.31833","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"1210_CR43","doi-asserted-by":"publisher","first-page":"C839","DOI":"10.1152\/ajpcell.00324.2017","volume":"315","author":"XG Nie","year":"2018","unstructured":"Nie XG, Fan DS, Huang YX et al (2018) Downregulation of microRNA-149 in retinal ganglion cells suppresses apoptosis through activation of the PI3K\/Akt signaling pathway in mice with glaucoma. Am J Physiol Cell Physiol 315:C839-c849. https:\/\/doi.org\/10.1152\/ajpcell.00324.2017","journal-title":"Am J Physiol Cell Physiol"},{"key":"1210_CR44","doi-asserted-by":"publisher","first-page":"194417","DOI":"10.1016\/j.bbagrm.2019.194417","volume":"1863","author":"S Panni","year":"2020","unstructured":"Panni S, Lovering RC, Porras P, Orchard S (2020) Non-coding RNA regulatory networks. Biochim Biophys Acta Gene Regul Mech 1863:194417. https:\/\/doi.org\/10.1016\/j.bbagrm.2019.194417","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"key":"1210_CR45","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.cell.2009.02.006","volume":"136","author":"CP Ponting","year":"2009","unstructured":"Ponting CP, Oliver PL, Reik W (2009) Evolution and functions of long noncoding RNAs. Cell 136:629\u2013641. https:\/\/doi.org\/10.1016\/j.cell.2009.02.006","journal-title":"Cell"},{"key":"1210_CR46","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.tibs.2018.09.012","volume":"44","author":"X Qian","year":"2019","unstructured":"Qian X, Zhao J, Yeung PY, Zhang QC, Kwok CK (2019) Revealing lncRNA structures and interactions by sequencing-based approaches. Trends Biochem Sci 44:33\u201352. https:\/\/doi.org\/10.1016\/j.tibs.2018.09.012","journal-title":"Trends Biochem Sci"},{"key":"1210_CR47","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nrg.2015.10","volume":"17","author":"JJ Quinn","year":"2016","unstructured":"Quinn JJ, Chang HY (2016) Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet 17:47\u201362. https:\/\/doi.org\/10.1038\/nrg.2015.10","journal-title":"Nat Rev Genet"},{"key":"1210_CR48","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/nrcardio.2015.124","volume":"13","author":"RS Rosenson","year":"2016","unstructured":"Rosenson RS, Brewer HB Jr, Ansell BJ et al (2016) Dysfunctional HDL and atherosclerotic cardiovascular disease. Nat Rev Cardiol 13:48\u201360. https:\/\/doi.org\/10.1038\/nrcardio.2015.124","journal-title":"Nat Rev Cardiol"},{"key":"1210_CR49","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/s41434-021-00219-z","volume":"28","author":"AG Ross","year":"2021","unstructured":"Ross AG, McDougald DS, Khan RS et al (2021) Rescue of retinal ganglion cells in optic nerve injury using cell-selective AAV mediated delivery of SIRT1. Gene Ther 28:256\u2013264. https:\/\/doi.org\/10.1038\/s41434-021-00219-z","journal-title":"Gene Ther"},{"key":"1210_CR50","doi-asserted-by":"publisher","first-page":"6135","DOI":"10.1038\/s41467-020-19664-2","volume":"11","author":"V Simion","year":"2020","unstructured":"Simion V, Zhou H, Haemmig S et al (2020) A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus. Nat Commun 11:6135. https:\/\/doi.org\/10.1038\/s41467-020-19664-2","journal-title":"Nat Commun"},{"key":"1210_CR51","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1089\/hum.2018.118","volume":"30","author":"EM Simpson","year":"2019","unstructured":"Simpson EM, Korecki AJ, Fornes O et al (2019) New MiniPromoter Ple345 (NEFL) drives strong and specific expression in retinal ganglion cells of mouse and primate retina. Hum Gene Ther 30:257\u2013272. https:\/\/doi.org\/10.1089\/hum.2018.118","journal-title":"Hum Gene Ther"},{"key":"1210_CR52","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.45051","author":"TM Sirey","year":"2019","unstructured":"Sirey TM, Roberts K, Haerty W et al (2019) The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity. Elife. https:\/\/doi.org\/10.7554\/eLife.45051","journal-title":"Elife"},{"key":"1210_CR53","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59980","author":"AD Skol","year":"2020","unstructured":"Skol AD, Jung SC, Sokovic AM et al (2020) Integration of genomics and transcriptomics predicts diabetic retinopathy susceptibility genes. Elife. https:\/\/doi.org\/10.7554\/eLife.59980","journal-title":"Elife"},{"key":"1210_CR54","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.tig.2015.03.007","volume":"31","author":"G St Laurent","year":"2015","unstructured":"St Laurent G, Wahlestedt C, Kapranov P (2015) The Landscape of long noncoding RNA classification. Trends Genet 31:239\u2013251. https:\/\/doi.org\/10.1016\/j.tig.2015.03.007","journal-title":"Trends Genet"},{"key":"1210_CR55","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","volume":"22","author":"L Statello","year":"2021","unstructured":"Statello L, Guo CJ, Chen LL, Huarte M (2021) Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol 22:96\u2013118. https:\/\/doi.org\/10.1038\/s41580-020-00315-9","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1210_CR56","doi-asserted-by":"publisher","first-page":"08","DOI":"10.31491\/csrc.2019.09.002","volume":"3","author":"KD Sun","year":"2019","unstructured":"Sun KD, Wang JQ, Zhang QL (2019) LncRNA MEG3 promotes glaucomatous retinal ganglion cell apoptosis via upregulating miR-106 target gene caspase-8. Clin Surg Res Commun 3:08\u201318. https:\/\/doi.org\/10.31491\/csrc.2019.09.002","journal-title":"Clin Surg Res Commun"},{"key":"1210_CR57","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216794","author":"A Suzuki","year":"2021","unstructured":"Suzuki A, Guerrini MM, Yamamoto K (2021) Functional genomics of autoimmune diseases. Ann Rheum Dis. https:\/\/doi.org\/10.1136\/annrheumdis-2019-216794","journal-title":"Ann Rheum Dis"},{"key":"1210_CR58","doi-asserted-by":"publisher","first-page":"100769","DOI":"10.1016\/j.preteyeres.2019.07.002","volume":"73","author":"SB Syc-Mazurek","year":"2019","unstructured":"Syc-Mazurek SB, Libby RT (2019) Axon injury signaling and compartmentalized injury response in glaucoma. Prog Retin Eye Res 73:100769. https:\/\/doi.org\/10.1016\/j.preteyeres.2019.07.002","journal-title":"Prog Retin Eye Res"},{"key":"1210_CR59","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/cac2.12108","volume":"41","author":"YT Tan","year":"2021","unstructured":"Tan YT, Lin JF, Li T et al (2021) LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer. Cancer Commun 41:109\u2013120. https:\/\/doi.org\/10.1002\/cac2.12108","journal-title":"Cancer Commun"},{"key":"1210_CR60","doi-asserted-by":"publisher","first-page":"C105","DOI":"10.1152\/ajpcell.00059.2020","volume":"319","author":"R Tang","year":"2020","unstructured":"Tang R, Wang YC, Mei X et al (2020) LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling. Am J Physiol Cell Physiol 319:C105-c115. https:\/\/doi.org\/10.1152\/ajpcell.00059.2020","journal-title":"Am J Physiol Cell Physiol"},{"key":"1210_CR61","doi-asserted-by":"publisher","first-page":"17032","DOI":"10.1038\/cddiscovery.2017.32","volume":"3","author":"CN Thomas","year":"2017","unstructured":"Thomas CN, Berry M, Logan A, Blanch RJ, Ahmed Z (2017) Caspases in retinal ganglion cell death and axon regeneration. Cell Death Discov 3:17032. https:\/\/doi.org\/10.1038\/cddiscovery.2017.32","journal-title":"Cell Death Discov"},{"key":"1210_CR62","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/nrg.2016.85","volume":"17","author":"I Ulitsky","year":"2016","unstructured":"Ulitsky I (2016) Evolution to the rescue: using comparative genomics to understand long non-coding RNAs. Nat Rev Genet 17:601\u2013614. https:\/\/doi.org\/10.1038\/nrg.2016.85","journal-title":"Nat Rev Genet"},{"key":"1210_CR63","doi-asserted-by":"publisher","first-page":"4267","DOI":"10.1167\/iovs.09-3484","volume":"50","author":"NJ Van Bergen","year":"2009","unstructured":"Van Bergen NJ, Wood JP, Chidlow G et al (2009) Recharacterization of the RGC-5 retinal ganglion cell line. Investig Ophthalmol Vis Sci 50:4267\u20134272. https:\/\/doi.org\/10.1167\/iovs.09-3484","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1210_CR64","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3389\/fnins.2017.00161","volume":"11","author":"M van Wyk","year":"2017","unstructured":"van Wyk M, Hulliger EC, Girod L, Ebneter A, Kleinlogel S (2017) Present molecular limitations of ON-bipolar cell targeted gene therapy. Front Neurosci 11:161. https:\/\/doi.org\/10.3389\/fnins.2017.00161","journal-title":"Front Neurosci"},{"key":"1210_CR65","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1007\/s12035-016-9793-6","volume":"54","author":"P Wan","year":"2017","unstructured":"Wan P, Su W, Zhuo Y (2017) The role of long noncoding RNAs in neurodegenerative diseases. Mol Neurobiol 54:2012\u20132021. https:\/\/doi.org\/10.1007\/s12035-016-9793-6","journal-title":"Mol Neurobiol"},{"key":"1210_CR66","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/s41418-019-0351-4","volume":"27","author":"P Wan","year":"2020","unstructured":"Wan P, Su W, Zhang Y et al (2020) LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia\/reperfusion injury. Cell Death Differ 27:176\u2013191. https:\/\/doi.org\/10.1038\/s41418-019-0351-4","journal-title":"Cell Death Differ"},{"key":"1210_CR67","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.molcel.2011.08.018","volume":"43","author":"KC Wang","year":"2011","unstructured":"Wang KC, Chang HY (2011) Molecular mechanisms of long noncoding RNAs. Mol Cell 43:904\u2013914. https:\/\/doi.org\/10.1016\/j.molcel.2011.08.018","journal-title":"Mol Cell"},{"key":"1210_CR68","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1161\/circresaha.117.305781","volume":"117","author":"JX Wang","year":"2015","unstructured":"Wang JX, Zhang XJ, Li Q et al (2015) MicroRNA-103\/107 regulate programmed necrosis and myocardial ischemia\/reperfusion injury through targeting FADD. Circ Res 117:352\u2013363. https:\/\/doi.org\/10.1161\/circresaha.117.305781","journal-title":"Circ Res"},{"key":"1210_CR69","doi-asserted-by":"publisher","first-page":"e921514","DOI":"10.12659\/msm.921514","volume":"26","author":"M Wang","year":"2020","unstructured":"Wang M, Li J, Zheng Y (2020) The potential role of nuclear factor erythroid 2-related factor 2 (Nrf2) in glaucoma: a review. Med Sci Monit 26:e921514. https:\/\/doi.org\/10.12659\/msm.921514","journal-title":"Med Sci Monit"},{"key":"1210_CR70","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1080\/02713683.2020.1843686","volume":"46","author":"L Wang","year":"2021","unstructured":"Wang L, Gong J, Wang J, Dan J, Wang P (2021a) Long non-coding RNA MALAT1 alleviates the elevated intraocular pressure (eiop)-induced glaucoma progression via sponging miR-149-5p. Curr Eye Res 46:903\u2013911. https:\/\/doi.org\/10.1080\/02713683.2020.1843686","journal-title":"Curr Eye Res"},{"key":"1210_CR71","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.ymthe.2020.09.024","volume":"29","author":"Z Wang","year":"2021","unstructured":"Wang Z, Chen X, Liu N et al (2021b) A nuclear long non-coding RNA LINC00618 accelerates ferroptosis in a manner dependent upon apoptosis. Mol Ther 29:263\u2013274. https:\/\/doi.org\/10.1016\/j.ymthe.2020.09.024","journal-title":"Mol Ther"},{"key":"1210_CR72","doi-asserted-by":"publisher","first-page":"R21","DOI":"10.1093\/hmg\/ddx184","volume":"26","author":"JL Wiggs","year":"2017","unstructured":"Wiggs JL, Pasquale LR (2017) Genetics of glaucoma. Hum Mol Genet 26:R21-r27. https:\/\/doi.org\/10.1093\/hmg\/ddx184","journal-title":"Hum Mol Genet"},{"key":"1210_CR73","doi-asserted-by":"publisher","first-page":"e1002654","DOI":"10.1371\/journal.pgen.1002654","volume":"8","author":"JL Wiggs","year":"2012","unstructured":"Wiggs JL, Yaspan BL, Hauser MA et al (2012) Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genet 8:e1002654. https:\/\/doi.org\/10.1371\/journal.pgen.1002654","journal-title":"PLoS Genet"},{"key":"1210_CR74","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1146\/annurev-vision-022720-094953","volume":"6","author":"PR Williams","year":"2020","unstructured":"Williams PR, Benowitz LI, Goldberg JL, He Z (2020) Axon regeneration in the mammalian optic nerve. Annu Rev Vis Sci 6:195\u2013213. https:\/\/doi.org\/10.1146\/annurev-vision-022720-094953","journal-title":"Annu Rev Vis Sci"},{"key":"1210_CR75","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s13258-021-01085-0","volume":"43","author":"X Wu","year":"2021","unstructured":"Wu X, Liu Y, Ji Y (2021) Carboxymethylated chitosan alleviated oxidative stress injury in retinal ganglion cells via IncRNA-THOR\/IGF2BP1 axis. Genes Genom 43:643\u2013651. https:\/\/doi.org\/10.1007\/s13258-021-01085-0","journal-title":"Genes Genom"},{"key":"1210_CR76","doi-asserted-by":"publisher","first-page":"e0242884","DOI":"10.1371\/journal.pone.0242884","volume":"15","author":"X Xia","year":"2020","unstructured":"Xia X, Yu CY, Bian M et al (2020) MEF2 transcription factors differentially contribute to retinal ganglion cell loss after optic nerve injury. PLoS ONE 15:e0242884. https:\/\/doi.org\/10.1371\/journal.pone.0242884","journal-title":"PLoS ONE"},{"key":"1210_CR77","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1167\/iovs.16-20412","volume":"58","author":"L Xie","year":"2017","unstructured":"Xie L, Jiang B, Mao M (2017) Expression profiling of extracellular long noncoding RNAs and message RNAs in aqueous humor of glaucoma patients. Investig Ophthalmol Vis Sci 58:185","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1210_CR78","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.ajpath.2018.12.011","volume":"189","author":"L Xie","year":"2019","unstructured":"Xie L, Mao M, Wang C et al (2019) Potential biomarkers for primary open-angle glaucoma identified by long noncoding RNA profiling in the aqueous humor. Am J Pathol 189:739\u2013752. https:\/\/doi.org\/10.1016\/j.ajpath.2018.12.011","journal-title":"Am J Pathol"},{"key":"1210_CR79","first-page":"896","volume":"22","author":"Y Xu","year":"2018","unstructured":"Xu Y, Xing YQ (2018) Long non-coding RNA GAS5 contributed to the development of glaucoma via regulating the TGF-beta signaling pathway. Eur Rev Med Pharmacol Sci 22:896\u2013902","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1210_CR80","doi-asserted-by":"publisher","first-page":"e0164941","DOI":"10.1371\/journal.pone.0164941","volume":"11","author":"L Xu","year":"2016","unstructured":"Xu L, Zhang Z, Xie T, Zhang X, Dai T (2016) Inhibition of BDNF-AS provides neuroprotection for retinal ganglion cells against ischemic injury. PLoS ONE 11:e0164941. https:\/\/doi.org\/10.1371\/journal.pone.0164941","journal-title":"PLoS ONE"},{"key":"1210_CR81","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.12659\/MSM.911930","volume":"25","author":"Y Xu","year":"2019","unstructured":"Xu Y, Wang X, Zhang Y (2019) Myocardial infarction-related transcripts (MIAT) participate in diabetic optic nerve injury by regulating heart shock protein 5 (HSPA5) via competitively binding to MicroRNA-379. Med Sci Monit 25:2096\u20132103. https:\/\/doi.org\/10.12659\/MSM.911930","journal-title":"Med Sci Monit"},{"key":"1210_CR82","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1166\/jbt.2021.2412","volume":"11","author":"K Yan","year":"2021","unstructured":"Yan K, Niu L, Tian H, Su F, Chen Y (2021) Long noncoding RNA maternally expressed gene 3 targets miR-30b and regulates the AKT serine\/threonine kinase 1\/phosphoinositide 3-kinase signaling pathway of H2O2-induced proliferation, apoptosis, and oxidative stress in retinal ganglion cells. J Biomater Tissue Eng 11:351\u2013358. https:\/\/doi.org\/10.1166\/jbt.2021.2412","journal-title":"J Biomater Tissue Eng"},{"key":"1210_CR83","doi-asserted-by":"publisher","first-page":"108915","DOI":"10.1016\/j.exer.2021.108915","volume":"215","author":"N Yang","year":"2021","unstructured":"Yang N, Yang J, He X, Zhang W, Xing Y (2021a) Construction and analysis of mRNA, lncRNA, and transcription factor regulatory networks after retinal ganglion cell injury. Exp Eye Res 215:108915. https:\/\/doi.org\/10.1016\/j.exer.2021.108915","journal-title":"Exp Eye Res"},{"key":"1210_CR84","doi-asserted-by":"publisher","first-page":"105096","DOI":"10.1016\/j.neuint.2021.105096","volume":"148","author":"S Yang","year":"2021","unstructured":"Yang S, Yang H, Luo Y et al (2021b) Long non-coding RNAs in neurodegenerative diseases. Neurochem Int 148:105096. https:\/\/doi.org\/10.1016\/j.neuint.2021.105096","journal-title":"Neurochem Int"},{"key":"1210_CR85","doi-asserted-by":"publisher","first-page":"346","DOI":"10.15252\/emmm.201505725","volume":"8","author":"J Yao","year":"2016","unstructured":"Yao J, Wang XQ, Li YJ et al (2016) Long non-coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling. EMBO Mol Med 8:346\u2013362. https:\/\/doi.org\/10.15252\/emmm.201505725","journal-title":"EMBO Mol Med"},{"key":"1210_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2014.06.043","volume":"547","author":"K Zhang","year":"2014","unstructured":"Zhang K, Shi ZM, Chang YN et al (2014) The ways of action of long non-coding RNAs in cytoplasm and nucleus. Gene 547:1\u20139. https:\/\/doi.org\/10.1016\/j.gene.2014.06.043","journal-title":"Gene"},{"key":"1210_CR87","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.omtn.2017.12.007","volume":"10","author":"L Zhang","year":"2018","unstructured":"Zhang L, Liang D, Chen C et al (2018) Circular siRNAs for reducing off-target effects and enhancing long-term gene silencing in cells and mice. Mol Ther Nucleic Acids 10:237\u2013244. https:\/\/doi.org\/10.1016\/j.omtn.2017.12.007","journal-title":"Mol Ther Nucleic Acids"},{"key":"1210_CR88","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1111\/febs.14827","volume":"286","author":"L Zhang","year":"2019","unstructured":"Zhang L, Dong Y, Wang Y et al (2019) Long non-coding RNAs in ocular diseases: new and potential therapeutic targets. FEBS J 286:2261\u20132272. https:\/\/doi.org\/10.1111\/febs.14827","journal-title":"FEBS J"},{"key":"1210_CR89","doi-asserted-by":"publisher","first-page":"3805","DOI":"10.1007\/s00417-021-05279-w","volume":"259","author":"F Zhang","year":"2021","unstructured":"Zhang F, Zhao Y, Cao M et al (2021a) The potential role of long noncoding RNAs in primary open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol 259:3805\u20133814. https:\/\/doi.org\/10.1007\/s00417-021-05279-w","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"1210_CR90","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1167\/iovs.62.3.13","volume":"62","author":"R Zhang","year":"2021","unstructured":"Zhang R, Feng Y, Lu J, Ge Y, Li H (2021b) lncRNA Ttc3-209 promotes the apoptosis of retinal ganglion cells in retinal ischemia reperfusion injury by targeting the miR-484\/Wnt8a axis. Investig Ophthalmol Vis Sci 62:13. https:\/\/doi.org\/10.1167\/iovs.62.3.13","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1210_CR91","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.3892\/etm.2019.8345","volume":"19","author":"M Zheng","year":"2020","unstructured":"Zheng M, Zheng Y, Gao M et al (2020) Expression and clinical value of lncRNA MALAT1 and lncRNA ANRIL in glaucoma patients. Exp Ther Med 19:1329\u20131335. https:\/\/doi.org\/10.3892\/etm.2019.8345","journal-title":"Exp Ther Med"},{"key":"1210_CR92","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1089\/hum.2019.056","volume":"30","author":"RR Zhou","year":"2019","unstructured":"Zhou RR, Li HB, You QS et al (2019) Silencing of GAS5 alleviates glaucoma in rat models by reducing retinal ganglion cell apoptosis. Hum Gene Ther 30:1505\u20131519. https:\/\/doi.org\/10.1089\/hum.2019.056","journal-title":"Hum Gene Ther"},{"key":"1210_CR93","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-020-01365-5","author":"M Zhou","year":"2020","unstructured":"Zhou M, Lu B, Tan W, Fu M (2020) Identification of lncRNA-miRNA-mRNA regulatory network associated with primary open angle glaucoma. BMC Ophthalmol. https:\/\/doi.org\/10.1186\/s12886-020-01365-5","journal-title":"BMC Ophthalmol"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-022-01210-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10571-022-01210-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-022-01210-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T16:16:50Z","timestamp":1677255410000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10571-022-01210-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":93,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["1210"],"URL":"https:\/\/doi.org\/10.1007\/s10571-022-01210-x","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,28]]},"assertion":[{"value":"5 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that can be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}}]}}