{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:43:04Z","timestamp":1787578984692,"version":"build-2736575974"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2016M3A9B4917320"],"award-info":[{"award-number":["2016M3A9B4917320"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Health and Welfare","award":["HI18C1492"],"award-info":[{"award-number":["HI18C1492"]}]},{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","award":["20018551,NTIS:1415179737"],"award-info":[{"award-number":["20018551,NTIS:1415179737"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1007\/s10571-022-01284-7","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T11:03:52Z","timestamp":1663326232000},"page":"2035-2052","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Substance P Reduces Infarct Size and Mortality After Ischemic Stroke, Possibly Through the M2 Polarization of Microglia\/Macrophages and Neuroprotection in the Ischemic Rat Brain"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6933-4947","authenticated-orcid":false,"given":"Woosung","family":"Ahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7096-9106","authenticated-orcid":false,"given":"Guangfan","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5916-7882","authenticated-orcid":false,"given":"Sumin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1656-0056","authenticated-orcid":false,"given":"Youngsook","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5579-0770","authenticated-orcid":false,"given":"Mingzi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"1284_CR1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.2174\/156720211796558050","volume":"8","author":"A Anghel","year":"2011","unstructured":"Anghel A, Taranu G, Seclaman E et al (2011) Safety of vascular endothelial and hepatocyte growth factor gene therapy in patients with critical limb ischemia. Curr Neurovasc Res 8:183\u2013189. https:\/\/doi.org\/10.2174\/156720211796558050","journal-title":"Curr Neurovasc Res"},{"key":"1284_CR2","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1038\/jcbfm.2009.86","volume":"29","author":"M Beaumont","year":"2009","unstructured":"Beaumont M, Lemasson B, Farion R et al (2009) Characterization of tumor angiogenesis in rat brain using iron-based vessel size index MRI in combination with gadolinium-based dynamic contrast-enhanced MRI. J Cereb Blood Flow Metab 29:1714\u20131726. https:\/\/doi.org\/10.1038\/jcbfm.2009.86","journal-title":"J Cereb Blood Flow Metab"},{"key":"1284_CR3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0304-3940(95)12062-9","volume":"200","author":"J Benrath","year":"1995","unstructured":"Benrath J, Zimmermann M, Gillardon F (1995) Substance P and nitric oxide mediate would healing of ultraviolet photodamaged rat skin: evidence for an effect of nitric oxide on keratinocyte proliferation. Neurosci Lett 200:17\u201320. https:\/\/doi.org\/10.1016\/0304-3940(95)12062-9","journal-title":"Neurosci Lett"},{"key":"1284_CR4","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.2174\/138161212802002670","volume":"18","author":"CV Borlongan","year":"2012","unstructured":"Borlongan CV, Rodrigues AA, Oliveira MC (2012) Breaking the barrier in stroke: what should we know? a mini-review. Curr Pharm Des 18:3615\u20133623. https:\/\/doi.org\/10.2174\/138161212802002670","journal-title":"Curr Pharm Des"},{"key":"1284_CR5","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s12974-017-1012-5","volume":"14","author":"AR Burmeister","year":"2017","unstructured":"Burmeister AR, Johnson MB, Chauhan VS et al (2017) Human microglia and astrocytes constitutively express the neurokinin-1 receptor and functionally respond to substance P. J Neuroinflammation 14:245. https:\/\/doi.org\/10.1186\/s12974-017-1012-5","journal-title":"J Neuroinflammation"},{"key":"1284_CR6","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/iej.12627","volume":"50","author":"J Caviedes-Bucheli","year":"2017","unstructured":"Caviedes-Bucheli J, Gomez-Sosa JF, Azuero-Holguin MM et al (2017) Angiogenic mechanisms of human dental pulp and their relationship with substance P expression in response to occlusal trauma. Int Endod J 50:339\u2013351. https:\/\/doi.org\/10.1111\/iej.12627","journal-title":"Int Endod J"},{"key":"1284_CR7","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s12903-021-01519-x","volume":"21","author":"J Caviedes-Bucheli","year":"2021","unstructured":"Caviedes-Bucheli J, Lopez-Moncayo LF, Mu\u00f1oz-Alvear HD et al (2021) Expression of substance P, calcitonin gene-related peptide and vascular endothelial growth factor in human dental pulp under different clinical stimuli. BMC Oral Health 21:152. https:\/\/doi.org\/10.1186\/s12903-021-01519-x","journal-title":"BMC Oral Health"},{"key":"1284_CR8","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1007\/s11095-006-0068-1","volume":"23","author":"AK Chappa","year":"2006","unstructured":"Chappa AK, Audus KL, Lunte SM (2006) Characteristics of substance P transport across the blood-brain barrier. Pharm Res 23:1201\u20131208. https:\/\/doi.org\/10.1007\/s11095-006-0068-1","journal-title":"Pharm Res"},{"key":"1284_CR9","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s11302-005-0649-1","volume":"1","author":"RA Cunha","year":"2005","unstructured":"Cunha RA (2005) Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade. Purinergic Signal 1:111\u2013134. https:\/\/doi.org\/10.1007\/s11302-005-0649-1","journal-title":"Purinergic Signal"},{"key":"1284_CR10","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3389\/fnins.2015.00277","volume":"9","author":"O Cuomo","year":"2015","unstructured":"Cuomo O, Vinciguerra A, Cerullo P et al (2015) Ionic homeostasis in brain conditioning. Front Neurosci 9:277. https:\/\/doi.org\/10.3389\/fnins.2015.00277","journal-title":"Front Neurosci"},{"key":"1284_CR11","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020412","volume":"7","author":"R Daneman","year":"2015","unstructured":"Daneman R, Prat A (2015) The blood-brain barrier. Cold Spring Harb Perspect Biol 7:a020412. https:\/\/doi.org\/10.1101\/cshperspect.a020412","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"1284_CR12","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1002\/jnr.20674","volume":"82","author":"KR Dave","year":"2005","unstructured":"Dave KR, Lange-Asschenfeldt C, Raval AP et al (2005) Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate\/gamma-aminobutyric acid release and biosynthesis. J Neurosci Res 82:665\u2013673. https:\/\/doi.org\/10.1002\/jnr.20674","journal-title":"J Neurosci Res"},{"key":"1284_CR13","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/s0165-0173(00)00033-3","volume":"33","author":"A de Mendon\u00e7a","year":"2000","unstructured":"de Mendon\u00e7a A, Sebasti\u00e3o AM, Ribeiro JA (2000) Adenosine: does it have a neuroprotective role after all? Brain Res Brain Res Rev 33:258\u2013274. https:\/\/doi.org\/10.1016\/s0165-0173(00)00033-3","journal-title":"Brain Res Brain Res Rev"},{"key":"1284_CR14","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1177\/153537020523000407","volume":"230","author":"AV Delgado","year":"2005","unstructured":"Delgado AV, McManus AT, Chambers JP (2005) Exogenous administration of Substance P enhances wound healing in a novel skin-injury model. Exp Biol Med (maywood) 230:271\u2013280. https:\/\/doi.org\/10.1177\/153537020523000407","journal-title":"Exp Biol Med (maywood)"},{"key":"1284_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067063","volume":"8","author":"V Desestret","year":"2013","unstructured":"Desestret V, Riou A, Chauveau F et al (2013) In vitro and in vivo models of cerebral ischemia show discrepancy in therapeutic effects of M2 macrophages. PLoS ONE 8:e67063. https:\/\/doi.org\/10.1371\/journal.pone.0067063","journal-title":"PLoS ONE"},{"key":"1284_CR16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1749-6632.2010.05826.x","volume":"1217","author":"SD Douglas","year":"2011","unstructured":"Douglas SD, Leeman SE (2011) Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation. Ann N Y Acad Sci 1217:83\u201395. https:\/\/doi.org\/10.1111\/j.1749-6632.2010.05826.x","journal-title":"Ann N Y Acad Sci"},{"key":"1284_CR17","unstructured":"Executive Summary of Stroke Statistics in Korea 2018: A Report from the Epidemiology Research Council of the Korean Stroke Society. https:\/\/j-stroke.org\/journal\/view.php?number=256. Accessed 19 Apr 2022"},{"key":"1284_CR18","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.pneurobio.2015.05.003","volume":"131","author":"R Franco","year":"2015","unstructured":"Franco R, Fern\u00e1ndez-Su\u00e1rez D (2015) Alternatively activated microglia and macrophages in the central nervous system. Prog Neurobiol 131:65\u201386. https:\/\/doi.org\/10.1016\/j.pneurobio.2015.05.003","journal-title":"Prog Neurobiol"},{"key":"1284_CR19","doi-asserted-by":"publisher","first-page":"26624","DOI":"10.1074\/jbc.M603007200","volume":"281","author":"C Frangi\u00e9","year":"2006","unstructured":"Frangi\u00e9 C, Zhang W, Perez J et al (2006) Extracellular Calpains Increase Tubular Epithelial Cell Mobility: implications for kidney repair after ischemia*. J Biol Chem 281:26624\u201326632. https:\/\/doi.org\/10.1074\/jbc.M603007200","journal-title":"J Biol Chem"},{"key":"1284_CR20","doi-asserted-by":"publisher","first-page":"3848","DOI":"10.3390\/ijms23073848","volume":"23","author":"S Frase","year":"2022","unstructured":"Frase S, L\u00f6ffler F, Hosp JA (2022) Enhancing post-stroke rehabilitation and preventing exo-focal dopaminergic degeneration in rats\u2014a role for substance P. Int J Mol Sci 23:3848. https:\/\/doi.org\/10.3390\/ijms23073848","journal-title":"Int J Mol Sci"},{"key":"1284_CR21","doi-asserted-by":"publisher","first-page":"3120","DOI":"10.1002\/cne.23582","volume":"522","author":"S Garbuzova-Davis","year":"2014","unstructured":"Garbuzova-Davis S, Haller E, Williams SN et al (2014) Compromised blood-brain barrier competence in remote brain areas in ischemic stroke rats at the chronic stage. J Comp Neurol 522:3120\u20133137. https:\/\/doi.org\/10.1002\/cne.23582","journal-title":"J Comp Neurol"},{"key":"1284_CR22","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12974-017-0909-3","volume":"14","author":"R Ge","year":"2017","unstructured":"Ge R, Tornero D, Hirota M et al (2017) Choroid plexus-cerebrospinal fluid route for monocyte-derived macrophages after stroke. J Neuroinflammation 14:153. https:\/\/doi.org\/10.1186\/s12974-017-0909-3","journal-title":"J Neuroinflammation"},{"key":"1284_CR23","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1016\/j.bbamem.2010.12.001","volume":"1808","author":"CV Gomes","year":"2011","unstructured":"Gomes CV, Kaster MP, Tom\u00e9 AR et al (2011) Adenosine receptors and brain diseases: neuroprotection and neurodegeneration. Biochim Biophys Acta 1808:1380\u20131399. https:\/\/doi.org\/10.1016\/j.bbamem.2010.12.001","journal-title":"Biochim Biophys Acta"},{"key":"1284_CR24","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nn.3953","volume":"18","author":"JD Haines","year":"2015","unstructured":"Haines JD, Herbin O, de la Hera B et al (2015) Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination. Nat Neurosci 18:511\u2013520. https:\/\/doi.org\/10.1038\/nn.3953","journal-title":"Nat Neurosci"},{"key":"1284_CR25","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.bbrc.2014.09.090","volume":"453","author":"HS Hong","year":"2014","unstructured":"Hong HS, Son Y (2014) Substance P ameliorates collagen II-induced arthritis in mice via suppression of the inflammatory response. Biochem Biophys Res Commun 453:179\u2013184. https:\/\/doi.org\/10.1016\/j.bbrc.2014.09.090","journal-title":"Biochem Biophys Res Commun"},{"key":"1284_CR26","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/nm.1909","volume":"15","author":"HS Hong","year":"2009","unstructured":"Hong HS, Lee J, Lee E et al (2009) A new role of substance P as an injury-inducible messenger for mobilization of CD29(+) stromal-like cells. Nat Med 15:425\u2013435. https:\/\/doi.org\/10.1038\/nm.1909","journal-title":"Nat Med"},{"key":"1284_CR27","doi-asserted-by":"publisher","first-page":"40","DOI":"10.33594\/000000004","volume":"52","author":"HS Hong","year":"2019","unstructured":"Hong HS, Kim S, Lee S et al (2019) Substance-P prevents cardiac ischemia-reperfusion injury by modulating stem cell mobilization and causing early suppression of injury-mediated inflammation. Cell Physiol Biochem 52:40\u201356. https:\/\/doi.org\/10.33594\/000000004","journal-title":"Cell Physiol Biochem"},{"key":"1284_CR28","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1161\/STROKEAHA.112.659656","volume":"43","author":"X Hu","year":"2012","unstructured":"Hu X, Li P, Guo Y et al (2012) Microglia\/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke 43:3063\u20133070. https:\/\/doi.org\/10.1161\/STROKEAHA.112.659656","journal-title":"Stroke"},{"key":"1284_CR29","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nrneurol.2014.207","volume":"11","author":"X Hu","year":"2015","unstructured":"Hu X, Leak RK, Shi Y et al (2015) Microglial and macrophage polarization\u2014new prospects for brain repair. Nat Rev Neurol 11:56\u201364. https:\/\/doi.org\/10.1038\/nrneurol.2014.207","journal-title":"Nat Rev Neurol"},{"key":"1284_CR30","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/sj.jcbfm.9600362","volume":"27","author":"F Imai","year":"2007","unstructured":"Imai F, Suzuki H, Oda J et al (2007) Neuroprotective effect of exogenous microglia in global brain ischemia. J Cereb Blood Flow Metab 27:488\u2013500. https:\/\/doi.org\/10.1038\/sj.jcbfm.9600362","journal-title":"J Cereb Blood Flow Metab"},{"key":"1284_CR31","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1097\/WNR.0b013e3283572206","volume":"23","author":"MH Jiang","year":"2012","unstructured":"Jiang MH, Chung E, Chi GF et al (2012) Substance P induces M2-type macrophages after spinal cord injury. NeuroReport 23:786\u2013792. https:\/\/doi.org\/10.1097\/WNR.0b013e3283572206","journal-title":"NeuroReport"},{"key":"1284_CR32","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1097\/WNR.0b013e3283650e3d","volume":"24","author":"MH Jiang","year":"2013","unstructured":"Jiang MH, Lim JE, Chi GF et al (2013) Substance P reduces apoptotic cell death possibly by modulating the immune response at the early stage after spinal cord injury. NeuroReport 24:846\u2013851. https:\/\/doi.org\/10.1097\/WNR.0b013e3283650e3d","journal-title":"NeuroReport"},{"key":"1284_CR33","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cyto.2014.10.003","volume":"71","author":"Y Jin","year":"2015","unstructured":"Jin Y, Hong HS, Son Y (2015) Substance P enhances mesenchymal stem cells-mediated immune modulation. Cytokine 71:145\u2013153. https:\/\/doi.org\/10.1016\/j.cyto.2014.10.003","journal-title":"Cytokine"},{"key":"1284_CR34","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1093\/brain\/awv079","volume":"138","author":"M Kanazawa","year":"2015","unstructured":"Kanazawa M, Kawamura K, Takahashi T et al (2015) Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke. Brain 138:1932\u20131948. https:\/\/doi.org\/10.1093\/brain\/awv079","journal-title":"Brain"},{"key":"1284_CR35","doi-asserted-by":"publisher","first-page":"42582","DOI":"10.1038\/srep42582","volume":"7","author":"M Kanazawa","year":"2017","unstructured":"Kanazawa M, Miura M, Toriyabe M et al (2017) Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats. Sci Rep 7:42582. https:\/\/doi.org\/10.1038\/srep42582","journal-title":"Sci Rep"},{"key":"1284_CR36","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.ejphar.2013.04.042","volume":"715","author":"V Kant","year":"2013","unstructured":"Kant V, Gopal A, Kumar D et al (2013) Topically applied substance P enhanced healing of open excision wound in rats. Eur J Pharmacol 715:345\u2013353. https:\/\/doi.org\/10.1016\/j.ejphar.2013.04.042","journal-title":"Eur J Pharmacol"},{"key":"1284_CR37","doi-asserted-by":"publisher","first-page":"8800","DOI":"10.3390\/ijms22168800","volume":"22","author":"S Kim","year":"2021","unstructured":"Kim S, Son Y (2021) Astrocytes stimulate microglial proliferation and M2 polarization in vitro through crosstalk between astrocytes and microglia. Int J Mol Sci 22:8800. https:\/\/doi.org\/10.3390\/ijms22168800","journal-title":"Int J Mol Sci"},{"key":"1284_CR38","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1634\/stemcells.2008-0108","volume":"26","author":"S-S Kim","year":"2008","unstructured":"Kim S-S, Yoo S-W, Park T-S et al (2008) Neural induction with neurogenin1 increases the therapeutic effects of mesenchymal stem cells in the ischemic brain. Stem Cells 26:2217\u20132228. https:\/\/doi.org\/10.1634\/stemcells.2008-0108","journal-title":"Stem Cells"},{"key":"1284_CR39","doi-asserted-by":"publisher","first-page":"E2477","DOI":"10.3390\/ijms20102477","volume":"20","author":"YE Kim","year":"2019","unstructured":"Kim YE, Sung SI, Chang YS et al (2019) Thrombin preconditioning enhances therapeutic efficacy of human wharton\u2019s jelly-derived mesenchymal stem cells in severe neonatal hypoxic ischemic encephalopathy. Int J Mol Sci 20:E2477. https:\/\/doi.org\/10.3390\/ijms20102477","journal-title":"Int J Mol Sci"},{"key":"1284_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121210","volume":"279","author":"S Kim","year":"2021","unstructured":"Kim S, Lee S, Lim J et al (2021) Human bone marrow-derived mesenchymal stem cells play a role as a vascular pericyte in the reconstruction of human BBB on the angiogenesis microfluidic chip. Biomaterials 279:121210. https:\/\/doi.org\/10.1016\/j.biomaterials.2021.121210","journal-title":"Biomaterials"},{"key":"1284_CR41","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1016\/j.ajpath.2015.02.011","volume":"185","author":"EC Leal","year":"2015","unstructured":"Leal EC, Carvalho E, Tellechea A et al (2015) Substance P promotes wound healing in diabetes by modulating inflammation and macrophage phenotype. Am J Pathol 185:1638\u20131648. https:\/\/doi.org\/10.1016\/j.ajpath.2015.02.011","journal-title":"Am J Pathol"},{"key":"1284_CR42","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.3892\/ijmm.2015.2171","volume":"35","author":"J-C Lee","year":"2015","unstructured":"Lee J-C, Tae H-J, Cho G-S et al (2015) Ischemic preconditioning protects neurons from damage and maintains the immunoreactivity of kynurenic acid in the gerbil hippocampal CA1 region following transient cerebral ischemia. Int J Mol Med 35:1537\u20131544. https:\/\/doi.org\/10.3892\/ijmm.2015.2171","journal-title":"Int J Mol Med"},{"key":"1284_CR43","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1002\/jnr.21087","volume":"84","author":"Q Li","year":"2006","unstructured":"Li Q, Ford MC, Lavik EB, Madri JA (2006) Modeling the neurovascular niche: VEGF- and BDNF-mediated cross-talk between neural stem cells and endothelial cells: an in vitro study. J Neurosci Res 84:1656\u20131668. https:\/\/doi.org\/10.1002\/jnr.21087","journal-title":"J Neurosci Res"},{"key":"1284_CR44","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/nm.1927","volume":"15","author":"A Liesz","year":"2009","unstructured":"Liesz A, Suri-Payer E, Veltkamp C et al (2009) Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med 15:192\u2013199. https:\/\/doi.org\/10.1038\/nm.1927","journal-title":"Nat Med"},{"key":"1284_CR45","doi-asserted-by":"publisher","first-page":"9417","DOI":"10.1038\/s41598-017-09639-7","volume":"7","author":"JE Lim","year":"2017","unstructured":"Lim JE, Chung E, Son Y (2017) A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K\/Akt\/mTOR pathway even in the presence of IFN\u03b3. Sci Rep 7:9417. https:\/\/doi.org\/10.1038\/s41598-017-09639-7","journal-title":"Sci Rep"},{"key":"1284_CR46","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3389\/fncel.2017.00391","volume":"11","author":"Z-H Lin","year":"2017","unstructured":"Lin Z-H, Wang S-Y, Chen L-L et al (2017) Methylene blue mitigates acute neuroinflammation after spinal cord injury through inhibiting NLRP3 inflammasome activation in microglia. Front Cell Neurosci 11:391","journal-title":"Front Cell Neurosci"},{"key":"1284_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00215","author":"S Lively","year":"2018","unstructured":"Lively S, Schlichter LC (2018) Microglia responses to pro-inflammatory stimuli (LPS, IFN\u03b3+TNF\u03b1) and reprogramming by resolving cytokines (IL-4, IL-10). Front Cell Neurosci. https:\/\/doi.org\/10.3389\/fncel.2018.00215","journal-title":"Front Cell Neurosci"},{"key":"1284_CR48","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/736104","volume":"2015","author":"A Mangiola","year":"2015","unstructured":"Mangiola A, Vigo V, Anile C et al (2015) Role and importance of IGF-1 in traumatic brain injuries. Biomed Res Int 2015:736104. https:\/\/doi.org\/10.1155\/2015\/736104","journal-title":"Biomed Res Int"},{"key":"1284_CR49","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.ajpath.2017.01.013","volume":"187","author":"M\u00c1 Manzanares","year":"2017","unstructured":"Manzanares M\u00c1, Usui A, Campbell DJ et al (2017) Transforming growth factors \u03b1 and \u03b2 Are essential for modeling cholangiocarcinoma desmoplasia and progression in a three-dimensional organotypic culture model. Am J Pathol 187:1068\u20131092. https:\/\/doi.org\/10.1016\/j.ajpath.2017.01.013","journal-title":"Am J Pathol"},{"key":"1284_CR50","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000152","author":"D Mozaffarian","year":"2015","unstructured":"Mozaffarian D, Benjamin EJ, Go AS et al (2015) Heart disease and stroke statistics\u20142015 update. Circulation. https:\/\/doi.org\/10.1161\/CIR.0000000000000152","journal-title":"Circulation"},{"key":"1284_CR51","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1161\/01.str.20.8.1037","volume":"20","author":"H Nagasawa","year":"1989","unstructured":"Nagasawa H, Kogure K (1989) Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion. Stroke 20:1037\u20131043. https:\/\/doi.org\/10.1161\/01.str.20.8.1037","journal-title":"Stroke"},{"key":"1284_CR52","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1046\/j.1365-2125.1999.00017.x","volume":"48","author":"DE Newby","year":"1999","unstructured":"Newby DE, Sciberras DG, Ferro CJ et al (1999) Substance P-induced vasodilatation is mediated by the neurokinin type 1 receptor but does not contribute to basal vascular tone in man. Br J Clin Pharmacol 48:336\u2013344. https:\/\/doi.org\/10.1046\/j.1365-2125.1999.00017.x","journal-title":"Br J Clin Pharmacol"},{"key":"1284_CR53","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.npep.2003.12.003","volume":"38","author":"AJ Nimmo","year":"2004","unstructured":"Nimmo AJ, Cernak I, Heath DL et al (2004) Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats. Neuropeptides 38:40\u201347. https:\/\/doi.org\/10.1016\/j.npep.2003.12.003","journal-title":"Neuropeptides"},{"key":"1284_CR54","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s00011-006-0079-8","volume":"55","author":"MC O\u2019Shaughnessy","year":"2006","unstructured":"O\u2019Shaughnessy MC, Vetsika E-K, Inglis JJ et al (2006) The effect of substance P on nitric oxide release in a rheumatoid arthritis model. Inflamm Res 55:236\u2013240. https:\/\/doi.org\/10.1007\/s00011-006-0079-8","journal-title":"Inflamm Res"},{"key":"1284_CR55","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12974-015-0270-3","volume":"12","author":"J Pan","year":"2015","unstructured":"Pan J, Jin J, Ge H et al (2015) Malibatol A regulates microglia M1\/M2 polarization in experimental stroke in a PPAR\u03b3-dependent manner. J Neuroinflammation 12:51. https:\/\/doi.org\/10.1186\/s12974-015-0270-3","journal-title":"J Neuroinflammation"},{"key":"1284_CR56","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1186\/s12974-016-0735-z","volume":"13","author":"M Pannell","year":"2016","unstructured":"Pannell M, Labuz D, Celik M\u00d6 et al (2016) Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides. J Neuroinflammation 13:262. https:\/\/doi.org\/10.1186\/s12974-016-0735-z","journal-title":"J Neuroinflammation"},{"key":"1284_CR57","doi-asserted-by":"publisher","first-page":"593","DOI":"10.3171\/JNS-07\/09\/0593","volume":"107","author":"S-W Park","year":"2007","unstructured":"Park S-W, Yan Y-P, Satriotomo I et al (2007) Substance P is a promoter of adult neural progenitor cell proliferation under normal and ischemic conditions. J Neurosurg 107:593\u2013599. https:\/\/doi.org\/10.3171\/JNS-07\/09\/0593","journal-title":"J Neurosurg"},{"key":"1284_CR58","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s11481-006-9025-3","volume":"1","author":"Y Persidsky","year":"2006","unstructured":"Persidsky Y, Ramirez SH, Haorah J, Kanmogne GD (2006) Blood-brain barrier: structural components and function under physiologic and pathologic conditions. J Neuroimmune Pharmacol 1:223\u2013236. https:\/\/doi.org\/10.1007\/s11481-006-9025-3","journal-title":"J Neuroimmune Pharmacol"},{"key":"1284_CR59","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.trsl.2020.08.005","volume":"228","author":"J Piao","year":"2021","unstructured":"Piao J, Park JS, Hwang DY et al (2021) Substance P blocks \u03b2-aminopropionitrile-induced aortic injury through modulation of M2 monocyte-skewed monocytopoiesis. Transl Res 228:76\u201393. https:\/\/doi.org\/10.1016\/j.trsl.2020.08.005","journal-title":"Transl Res"},{"key":"1284_CR60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004764","volume":"4","author":"A Popp","year":"2009","unstructured":"Popp A, Jaenisch N, Witte OW, Frahm C (2009) Identification of ischemic regions in a rat model of stroke. PLoS ONE 4:e4764. https:\/\/doi.org\/10.1371\/journal.pone.0004764","journal-title":"PLoS ONE"},{"key":"1284_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/term.388","volume":"6","author":"T Rada","year":"2012","unstructured":"Rada T, Santos TC, Marques AP et al (2012) Osteogenic differentiation of two distinct subpopulations of human adipose-derived stem cells: an in vitro and in vivo study. J Tissue Eng Regen Med 6:1\u201311. https:\/\/doi.org\/10.1002\/term.388","journal-title":"J Tissue Eng Regen Med"},{"key":"1284_CR62","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1093\/brain\/awq344","volume":"134","author":"R Reitmeir","year":"2011","unstructured":"Reitmeir R, Kilic E, Kilic U et al (2011) Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity. Brain 134:84\u201399. https:\/\/doi.org\/10.1093\/brain\/awq344","journal-title":"Brain"},{"key":"1284_CR63","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/816460","volume":"2015","author":"T R\u0151szer","year":"2015","unstructured":"R\u0151szer T (2015) Understanding the mysterious M2 macrophage through activation markers and effector mechanisms. Mediators Inflamm 2015:816460. https:\/\/doi.org\/10.1155\/2015\/816460","journal-title":"Mediators Inflamm"},{"key":"1284_CR64","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E et al (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9:676\u2013682. https:\/\/doi.org\/10.1038\/nmeth.2019","journal-title":"Nat Methods"},{"key":"1284_CR65","doi-asserted-by":"publisher","DOI":"10.3791\/52537","author":"JM Schwarz","year":"2015","unstructured":"Schwarz JM (2015) Using fluorescence activated cell sorting to examine cell-type-specific gene expression in rat brain tissue. JoVE. https:\/\/doi.org\/10.3791\/52537","journal-title":"JoVE"},{"key":"1284_CR66","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.578648","volume":"11","author":"SK Shahi","year":"2020","unstructured":"Shahi SK, Jensen SN, Murra AC et al (2020) Human commensal prevotella histicola ameliorates disease as effectively as interferon-beta in the experimental autoimmune encephalomyelitis. Front Immunol 11:578648. https:\/\/doi.org\/10.3389\/fimmu.2020.578648","journal-title":"Front Immunol"},{"key":"1284_CR67","doi-asserted-by":"publisher","first-page":"753","DOI":"10.2741\/1833","volume":"11","author":"M Shimamura","year":"2006","unstructured":"Shimamura M, Sato N, Yoshimura S et al (2006) HVJ-based non-viral gene transfer method: successful gene therapy using HGF and VEGF genes in experimental ischemia. Front Biosci 11:753\u2013759. https:\/\/doi.org\/10.2741\/1833","journal-title":"Front Biosci"},{"key":"1284_CR68","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.bbi.2014.03.013","volume":"40","author":"JA Shin","year":"2014","unstructured":"Shin JA, Lim SM, Jeong SI et al (2014) Noggin improves ischemic brain tissue repair and promotes alternative activation of microglia in mice. Brain Behav Immun 40:143\u2013154. https:\/\/doi.org\/10.1016\/j.bbi.2014.03.013","journal-title":"Brain Behav Immun"},{"key":"1284_CR69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yfrne.2014.05.003","volume":"36","author":"F Sohrabji","year":"2015","unstructured":"Sohrabji F (2015) Estrogen-IGF-1 interactions in neuroprotection: ischemic stroke as a case study. Front Neuroendocrinol 36:1\u201314. https:\/\/doi.org\/10.1016\/j.yfrne.2014.05.003","journal-title":"Front Neuroendocrinol"},{"key":"1284_CR70","doi-asserted-by":"publisher","first-page":"E676","DOI":"10.3390\/molecules22040676","volume":"22","author":"J Stockwell","year":"2017","unstructured":"Stockwell J, Jakova E, Cayabyab FS (2017) Adenosine A1 and A2A receptors in the brain: current research and their role in neurodegeneration. Molecules 22:E676. https:\/\/doi.org\/10.3390\/molecules22040676","journal-title":"Molecules"},{"key":"1284_CR71","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/eji.1830090212","volume":"9","author":"CA Sunderland","year":"1979","unstructured":"Sunderland CA, McMaster WR, Williams AF (1979) Purification with monoclonal antibody of a predominant leukocyte-common antigen and glycoprotein from rat thymocytes. Eur J Immunol 9:155\u2013159. https:\/\/doi.org\/10.1002\/eji.1830090212","journal-title":"Eur J Immunol"},{"key":"1284_CR72","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.yexmp.2015.03.010","volume":"98","author":"AH Tennakoon","year":"2015","unstructured":"Tennakoon AH, Izawa T, Wijesundera KK et al (2015) Analysis of glial fibrillary acidic protein (GFAP)-expressing ductular cells in a rat liver cirrhosis model induced by repeated injections of thioacetamide (TAA). Exp Mol Pathol 98:476\u2013485. https:\/\/doi.org\/10.1016\/j.yexmp.2015.03.010","journal-title":"Exp Mol Pathol"},{"key":"1284_CR73","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1179\/1743132813Y.0000000210","volume":"35","author":"L Wang","year":"2013","unstructured":"Wang L, Lin Z, Shao B et al (2013) Therapeutic applications of bone marrow-derived stem cells in ischemic stroke. Neurol Res 35:470\u2013478. https:\/\/doi.org\/10.1179\/1743132813Y.0000000210","journal-title":"Neurol Res"},{"key":"1284_CR74","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.stem.2020.08.005","volume":"27","author":"Z Wei","year":"2020","unstructured":"Wei Z, Schnellmann R, Pruitt HC, Gerecht S (2020) Hydrogel network dynamics regulate vascular morphogenesis. Cell Stem Cell 27:798-812.e6. https:\/\/doi.org\/10.1016\/j.stem.2020.08.005","journal-title":"Cell Stem Cell"},{"key":"1284_CR75","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fneng.2013.00007","volume":"6","author":"AD Wong","year":"2013","unstructured":"Wong AD, Ye M, Levy AF et al (2013) The blood-brain barrier: an engineering perspective. Front Neuroeng 6:7. https:\/\/doi.org\/10.3389\/fneng.2013.00007","journal-title":"Front Neuroeng"},{"key":"1284_CR76","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12974-020-02041-7","volume":"18","author":"H Wu","year":"2021","unstructured":"Wu H, Zheng J, Xu S et al (2021) Mer regulates microglial\/macrophage M1\/M2 polarization and alleviates neuroinflammation following traumatic brain injury. J Neuroinflammation 18:2. https:\/\/doi.org\/10.1186\/s12974-020-02041-7","journal-title":"J Neuroinflammation"},{"key":"1284_CR77","doi-asserted-by":"publisher","first-page":"16866","DOI":"10.1038\/srep16866","volume":"5","author":"C W\u00fclfing","year":"2015","unstructured":"W\u00fclfing C, G\u00fcnther HS (2015) Dendritic cells and macrophages neurally hard-wired in the lymph node. Sci Rep 5:16866. https:\/\/doi.org\/10.1038\/srep16866","journal-title":"Sci Rep"},{"key":"1284_CR78","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.biocel.2017.05.030","volume":"89","author":"L Yang","year":"2017","unstructured":"Yang L, Li G, Ye J et al (2017) Substance P enhances endogenous neurogenesis to improve functional recovery after spinal cord injury. Int J Biochem Cell Biol 89:110\u2013119. https:\/\/doi.org\/10.1016\/j.biocel.2017.05.030","journal-title":"Int J Biochem Cell Biol"},{"key":"1284_CR79","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/1471-2105-13-134","volume":"13","author":"J Ye","year":"2012","unstructured":"Ye J, Coulouris G, Zaretskaya I et al (2012) Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction. BMC Bioinform 13:134. https:\/\/doi.org\/10.1186\/1471-2105-13-134","journal-title":"BMC Bioinform"},{"key":"1284_CR80","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.7150\/thno.53749","volume":"11","author":"A Zhang","year":"2021","unstructured":"Zhang A, Xu Y, Xu H et al (2021) Lactate-induced M2 polarization of tumor-associated macrophages promotes the invasion of pituitary adenoma by secreting CCL17. Theranostics 11:3839\u20133852. https:\/\/doi.org\/10.7150\/thno.53749","journal-title":"Theranostics"},{"key":"1284_CR81","volume-title":"Pediatric Critical Care","author":"J Zimmerman","year":"2016","unstructured":"Zimmerman J, Fuhrman B (2016) Pediatric Critical Care, 5th edn. Elsevier, Amsterdam","edition":"5"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-022-01284-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10571-022-01284-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-022-01284-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T06:27:59Z","timestamp":1687501679000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10571-022-01284-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,16]]},"references-count":81,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["1284"],"URL":"https:\/\/doi.org\/10.1007\/s10571-022-01284-7","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,16]]},"assertion":[{"value":"6 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Animal management and all the animal experimental procedures in this study were approved by the Institutional Animal Care and Use Committee of Kyung-Hee University (KHUASP10-006).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}