{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T07:08:25Z","timestamp":1793776105694,"version":"4.6.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81871519"],"award-info":[{"award-number":["81871519"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1007\/s10571-022-01305-5","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T10:31:51Z","timestamp":1668076311000},"page":"2273-2288","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hypoxic White Matter Injury and Recovery After Reoxygenation in Adult Mice: Magnetic Resonance Imaging Findings and Histological Studies"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5957-7400","authenticated-orcid":false,"given":"Yanqiu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9102-0813","authenticated-orcid":false,"given":"Hong","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0160-3949","authenticated-orcid":false,"given":"Wenrui","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5904-5495","authenticated-orcid":false,"given":"Lu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4645-1646","authenticated-orcid":false,"given":"Fengjuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9311-2965","authenticated-orcid":false,"given":"Jianzhong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0840-198X","authenticated-orcid":false,"given":"Minglu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4929-7103","authenticated-orcid":false,"given":"Lingling","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-5558","authenticated-orcid":false,"given":"Shanhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0452-1885","authenticated-orcid":false,"given":"Jiaxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"issue":"2","key":"1305_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.stem.2020.09.019","volume":"28","author":"KC Allan","year":"2021","unstructured":"Allan KC, Hu LR, Scavuzzo MA, Morton AR, Gevorgyan AS, Cohn EF, Clayton BLL, Bederman IR, Hung S, Bartels CF, Madhavan M, Tesar PJ (2021) Non-canonical targets of hif1a impair oligodendrocyte progenitor cell function. Cell Stem Cell 28(2):257-272.e211. https:\/\/doi.org\/10.1016\/j.stem.2020.09.019","journal-title":"Cell Stem Cell"},{"issue":"11","key":"1305_CR2","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1002\/glia.22658","volume":"62","author":"SA Back","year":"2014","unstructured":"Back SA, Rosenberg PA (2014) Pathophysiology of glia in perinatal white matter injury. Glia 62(11):1790\u20131815. https:\/\/doi.org\/10.1002\/glia.22658","journal-title":"Glia"},{"issue":"6","key":"1305_CR3","doi-asserted-by":"publisher","first-page":"656","DOI":"10.2174\/1381612822666151204000636","volume":"22","author":"A Barateiro","year":"2016","unstructured":"Barateiro A, Brites D, Fernandes A (2016) Oligodendrocyte development and myelination in neurodevelopment: molecular mechanisms in health and disease. Curr Pharm Des 22(6):656\u2013679. https:\/\/doi.org\/10.2174\/1381612822666151204000636","journal-title":"Curr Pharm Des"},{"issue":"3","key":"1305_CR4","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/path.2980","volume":"226","author":"J Cai","year":"2012","unstructured":"Cai J, Tuong CM, Zhang Y, Shields CB, Guo G, Fu H, Gozal D (2012) Mouse intermittent hypoxia mimicking apnoea of prematurity: effects on myelinogenesis and axonal maturation. J Pathol 226(3):495\u2013508. https:\/\/doi.org\/10.1002\/path.2980","journal-title":"J Pathol"},{"issue":"6","key":"1305_CR5","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1016\/j.neuron.2020.09.033","volume":"108","author":"M Chavali","year":"2020","unstructured":"Chavali M, Ulloa-Navas MJ, P\u00e9rez-Borred\u00e1 P, Garcia-Verdugo JM, McQuillen PS, Huang EJ, Rowitch DH (2020) Wnt-dependent oligodendroglial-endothelial interactions regulate white matter vascularization and attenuate injury. Neuron 108(6):1130-1145.e1135. https:\/\/doi.org\/10.1016\/j.neuron.2020.09.033","journal-title":"Neuron"},{"key":"1305_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-021-00745-1","author":"L Chen","year":"2021","unstructured":"Chen L, Ren SY, Li RX, Liu K, Chen JF, Yang YJ, Deng YB, Wang HZ, Xiao L, Mei F, Wang F (2021) Chronic exposure to hypoxia inhibits myelinogenesis and causes motor coordination deficits in adult mice. Neurosci Bull. https:\/\/doi.org\/10.1007\/s12264-021-00745-1","journal-title":"Neurosci Bull"},{"issue":"1","key":"1305_CR7","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1093\/brain\/awx312","volume":"141","author":"BAC Cree","year":"2018","unstructured":"Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM, Xiao L, Chan JR, Fancy SPJ (2018) Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury. Brain J Neurol 141(1):85\u201398. https:\/\/doi.org\/10.1093\/brain\/awx312","journal-title":"Brain J Neurol"},{"issue":"2","key":"1305_CR8","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/s1044-7431(03)00210-0","volume":"24","author":"MR Dawson","year":"2003","unstructured":"Dawson MR, Polito A, Levine JM, Reynolds R (2003) NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS. Mol Cell Neurosci 24(2):476\u2013488. https:\/\/doi.org\/10.1016\/s1044-7431(03)00210-0","journal-title":"Mol Cell Neurosci"},{"issue":"3","key":"1305_CR9","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1164\/rccm.201202-0355OC","volume":"186","author":"JW Dodd","year":"2012","unstructured":"Dodd JW, Chung AW, van den Broek MD, Barrick TR, Charlton RA, Jones PW (2012) Brain structure and function in chronic obstructive pulmonary disease: a multimodal cranial magnetic resonance imaging study. Am J Respir Crit Care Med 186(3):240\u2013245. https:\/\/doi.org\/10.1164\/rccm.201202-0355OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"1305_CR10","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00401-017-1741-7","volume":"134","author":"GJ Duncan","year":"2017","unstructured":"Duncan GJ, Plemel JR, Assinck P, Manesh SB, Muir FGW, Hirata R, Berson M, Liu J, Wegner M, Emery B, Moore GRW, Tetzlaff W (2017) Myelin regulatory factor drives remyelination in multiple sclerosis. Acta Neuropathol 134(3):403\u2013422. https:\/\/doi.org\/10.1007\/s00401-017-1741-7","journal-title":"Acta Neuropathol"},{"issue":"6005","key":"1305_CR11","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1126\/science.1190927","volume":"330","author":"B Emery","year":"2010","unstructured":"Emery B (2010) Regulation of oligodendrocyte differentiation and myelination. Science (new York, NY) 330(6005):779\u2013782. https:\/\/doi.org\/10.1126\/science.1190927","journal-title":"Science (new York, NY)"},{"key":"1305_CR12","doi-asserted-by":"publisher","first-page":"33596","DOI":"10.1038\/srep33596","volume":"6","author":"C Fan","year":"2016","unstructured":"Fan C, Zhao Y, Yu Q, Yin W, Liu H, Lin J, Yang T, Fan M, Gesang L, Zhang J (2016) Reversible brain abnormalities in people without signs of mountain sickness during high-altitude exposure. Sci Rep 6:33596. https:\/\/doi.org\/10.1038\/srep33596","journal-title":"Sci Rep"},{"key":"1305_CR13","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ejpn.2020.06.003","volume":"28","author":"D Gosar","year":"2020","unstructured":"Gosar D, Tretnjak V, Bregant T, Neubauer D, Derganc M (2020) Reduced white-matter integrity and lower speed of information processing in adolescents with mild and moderate neonatal hypoxic-ischaemic encephalopathy. European J Paediatr Neurol EJPN off j European Paediatr Neurol Soc 28:205\u2013213. https:\/\/doi.org\/10.1016\/j.ejpn.2020.06.003","journal-title":"European J Paediatr Neurol EJPN off j European Paediatr Neurol Soc"},{"issue":"1","key":"1305_CR14","doi-asserted-by":"publisher","first-page":"3887","DOI":"10.1038\/s41467-019-11638-3","volume":"10","author":"L Kirby","year":"2019","unstructured":"Kirby L, Jin J, Cardona JG, Smith MD, Martin KA, Wang J, Strasburger H, Herbst L, Alexis M, Karnell J, Davidson T, Dutta R, Goverman J, Bergles D, Calabresi PA (2019) Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination. Nat Commun 10(1):3887. https:\/\/doi.org\/10.1038\/s41467-019-11638-3","journal-title":"Nat Commun"},{"key":"1305_CR15","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/978-1-4939-7531-0_7","volume-title":"Preclinical MRI. Methods in Molecular Biology","author":"S Lope-Piedrafita","year":"2018","unstructured":"Lope-Piedrafita S (2018) Diffusion tensor imaging (DTI). In: Garc\u00eda Mart\u00edn M, L\u00f3pez Larrubia P (eds) Preclinical MRI. Methods in Molecular Biology, vol 1718. Humana Press, New York, pp 103\u2013116"},{"issue":"5","key":"1305_CR16","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1152\/japplphysiol.00955.2014","volume":"118","author":"AM Luks","year":"2015","unstructured":"Luks AM (2015) Physiology in medicine: a physiologic approach to prevention and treatment of acute high-altitude illnesses. J Appl Physiol (bethesda) 118(5):509\u2013519. https:\/\/doi.org\/10.1152\/japplphysiol.00955.2014","journal-title":"J Appl Physiol (bethesda)"},{"issue":"7","key":"1305_CR17","first-page":"967","volume":"31","author":"PM Macey","year":"2008","unstructured":"Macey PM, Kumar R, Woo MA, Valladares EM, Yan-Go FL, Harper RM (2008) Brain structural changes in obstructive sleep apnea. Sleep 31(7):967\u2013977","journal-title":"Sleep"},{"issue":"3","key":"1305_CR18","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/s41401-020-0437-z","volume":"42","author":"M Mao","year":"2021","unstructured":"Mao M, Yang L, Jin Z, Li LX, Wang YR, Li TT, Zhao YJ, Ai J (2021) Impact of intrauterine hypoxia on adolescent and adult cognitive function in rat offspring: sexual differences and the effects of spermidine intervention. Acta Pharmacol Sin 42(3):361\u2013369. https:\/\/doi.org\/10.1038\/s41401-020-0437-z","journal-title":"Acta Pharmacol Sin"},{"issue":"998","key":"1305_CR19","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1136\/pgmj.2008.068296","volume":"84","author":"D Martin","year":"2008","unstructured":"Martin D, Windsor J (2008) From mountain to bedside: understanding the clinical relevance of human acclimatisation to high-altitude hypoxia. Postgrad Med j 84(998):622\u2013627. https:\/\/doi.org\/10.1136\/pgmj.2008.068296","journal-title":"Postgrad Med j"},{"issue":"12","key":"1305_CR20","doi-asserted-by":"publisher","first-page":"3516","DOI":"10.1161\/strokeaha.113.002813","volume":"44","author":"N Miyamoto","year":"2013","unstructured":"Miyamoto N, Maki T, Pham LD, Hayakawa K, Seo JH, Mandeville ET, Mandeville JB, Kim KW, Lo EH, Arai K (2013) Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke 44(12):3516\u20133521. https:\/\/doi.org\/10.1161\/strokeaha.113.002813","journal-title":"Stroke"},{"issue":"9","key":"1305_CR21","first-page":"1445","volume":"23","author":"P Mukherjee","year":"2002","unstructured":"Mukherjee P, Miller JH, Shimony JS, Philip JV, Nehra D, Snyder AZ, Conturo TE, Neil JJ, McKinstry RC (2002) Diffusion-tensor MR imaging of gray and white matter development during normal human brain maturation. AJNR Am J Neuroradiol 23(9):1445\u20131456","journal-title":"AJNR Am J Neuroradiol"},{"issue":"3","key":"1305_CR22","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.resp.2010.06.013","volume":"173","author":"PP Patwari","year":"2010","unstructured":"Patwari PP, Carroll MS, Rand CM, Kumar R, Harper R, Weese-Mayer DE (2010) Congenital central hypoventilation syndrome and the PHOX2B gene: a model of respiratory and autonomic dysregulation. Respir Physiol Neurobiol 173(3):322\u2013335. https:\/\/doi.org\/10.1016\/j.resp.2010.06.013","journal-title":"Respir Physiol Neurobiol"},{"issue":"2","key":"1305_CR23","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/0304-3940(89)90528-4","volume":"101","author":"V Ravindranath","year":"1989","unstructured":"Ravindranath V, Shivakumar BR, Anandatheerthavarada HK (1989) Low glutathione levels in brain regions of aged rats. Neurosci Lett 101(2):187\u2013190. https:\/\/doi.org\/10.1016\/0304-3940(89)90528-4","journal-title":"Neurosci Lett"},{"issue":"6","key":"1305_CR24","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/j.neuron.2017.11.026","volume":"96","author":"C Sampaio-Baptista","year":"2017","unstructured":"Sampaio-Baptista C, Johansen-Berg H (2017) White matter plasticity in the adult brain. Neuron 96(6):1239\u20131251. https:\/\/doi.org\/10.1016\/j.neuron.2017.11.026","journal-title":"Neuron"},{"issue":"6","key":"1305_CR25","first-page":"1056","volume":"40","author":"T Sasaki","year":"1999","unstructured":"Sasaki T, Senda M (1999) Evaluation of glutathione localization in brain using 99mTc meso-HMPAO. J Nucl Med off Pub Soc Nucl Medi 40(6):1056\u20131060","journal-title":"J Nucl Med off Pub Soc Nucl Medi"},{"issue":"2","key":"1305_CR26","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/s0014-4886(03)00295-4","volume":"184","author":"ED Schwartz","year":"2003","unstructured":"Schwartz ED, Hackney DB (2003) Diffusion-weighted MRI and the evaluation of spinal cord axonal integrity following injury and treatment. Exp Neurol 184(2):570\u2013589. https:\/\/doi.org\/10.1016\/s0014-4886(03)00295-4","journal-title":"Exp Neurol"},{"issue":"3","key":"1305_CR27","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","volume":"148","author":"GL Semenza","year":"2012","unstructured":"Semenza GL (2012) Hypoxia-inducible factors in physiology and medicine. Cell 148(3):399\u2013408. https:\/\/doi.org\/10.1016\/j.cell.2012.01.021","journal-title":"Cell"},{"issue":"10","key":"1305_CR28","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1242\/dev.01114","volume":"131","author":"CC Stolt","year":"2004","unstructured":"Stolt CC, Lommes P, Friedrich RP, Wegner M (2004) Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy. Development (cambridge, England) 131(10):2349\u20132358. https:\/\/doi.org\/10.1242\/dev.01114","journal-title":"Development (cambridge, England)"},{"issue":"10","key":"1305_CR29","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.5665\/sleep.3038","volume":"36","author":"SC Veasey","year":"2013","unstructured":"Veasey SC, Lear J, Zhu Y, Grinspan JB, Hare DJ, Wang S, Bunch D, Doble PA, Robinson SR (2013) Long-term intermittent hypoxia elevates cobalt levels in the brain and injures white matter in adult mice. Sleep 36(10):1471\u20131481. https:\/\/doi.org\/10.5665\/sleep.3038","journal-title":"Sleep"},{"issue":"1","key":"1305_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0166-4328(01)00380-1","volume":"132","author":"V V\u00f5ikar","year":"2002","unstructured":"V\u00f5ikar V, Rauvala H, Ikonen E (2002) Cognitive deficit and development of motor impairment in a mouse model of niemann-pick type C disease. Behav Brain Res 132(1):1\u201310. https:\/\/doi.org\/10.1016\/s0166-4328(01)00380-1","journal-title":"Behav Brain Res"},{"issue":"4","key":"1305_CR31","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.neuron.2018.07.017","volume":"99","author":"F Wang","year":"2018","unstructured":"Wang F, Yang YJ, Yang N, Chen XJ, Huang NX, Zhang J, Wu Y, Liu Z, Gao X, Li T, Pan GQ, Liu SB, Li HL, Fancy SPJ, Xiao L, Chan JR, Mei F (2018) Enhancing oligodendrocyte myelination rescues synaptic loss and improves functional recovery after chronic hypoxia. Neuron 99(4):689-701.e685. https:\/\/doi.org\/10.1016\/j.neuron.2018.07.017","journal-title":"Neuron"},{"key":"1305_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105212","volume":"148","author":"H Wang","year":"2021","unstructured":"Wang H, Liu M, Zou G, Wang L, Duan W, He X, Ji M, Zou X, Hu Y, Yang J, Chen G (2021) Deletion of PDK1 in oligodendrocyte lineage cells causes white matter abnormality and myelination defect in the central nervous system. Neurobiol Dis 148:105212. https:\/\/doi.org\/10.1016\/j.nbd.2020.105212","journal-title":"Neurobiol Dis"},{"issue":"4","key":"1305_CR33","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1152\/jappl.1994.76.4.1643","volume":"76","author":"EE Wolfel","year":"1994","unstructured":"Wolfel EE, Selland MA, Mazzeo RS, Reeves JT (1994) Systemic hypertension at 4,300 m is related to sympathoadrenal activity. J Appl Physiol (bethesda) 76(4):1643\u20131650. https:\/\/doi.org\/10.1152\/jappl.1994.76.4.1643","journal-title":"J Appl Physiol (bethesda)"},{"key":"1305_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136705","author":"L Xu","year":"2021","unstructured":"Xu L, Song H, Qiu Q, Jiang T, Ge P, Su Z, Ma W, Zhang R, Huang C, Li S, Lin D, Zhang J (2021) Different expressions of hif-1\u03b1 and metabolism in brain and major visceral organs of acute hypoxic mice. Int j Mol Sci. https:\/\/doi.org\/10.3390\/ijms22136705","journal-title":"Int j Mol Sci"},{"issue":"2","key":"1305_CR35","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1089\/ham.2011.1073","volume":"13","author":"H Zhang","year":"2012","unstructured":"Zhang H, Lin J, Sun Y, Huang Y, Ye H, Wang X, Yang T, Jiang X, Zhang J (2012a) Compromised white matter microstructural integrity after mountain climbing: evidence from diffusion tensor imaging. High Alt Med Biol 13(2):118\u2013125. https:\/\/doi.org\/10.1089\/ham.2011.1073","journal-title":"High Alt Med Biol"},{"issue":"2","key":"1305_CR36","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-000844","volume":"2","author":"H Zhang","year":"2012","unstructured":"Zhang H, Wang X, Lin J, Sun Y, Huang Y, Yang T, Zheng S, Fan M, Zhang J (2012b) Grey and white matter abnormalities in chronic obstructive pulmonary disease: a case-control study. BMJ Open 2(2):e000844. https:\/\/doi.org\/10.1136\/bmjopen-2012-000844","journal-title":"BMJ Open"},{"issue":"7","key":"1305_CR37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068621","volume":"8","author":"J Zhang","year":"2013","unstructured":"Zhang J, Zhang H, Li J, Chen J, Han Q, Lin J, Yang T, Fan M (2013) Adaptive modulation of adult brain gray and white matter to high altitude: structural MRI studies. PLoS ONE 8(7):e68621. https:\/\/doi.org\/10.1371\/journal.pone.0068621","journal-title":"PLoS ONE"},{"issue":"10","key":"1305_CR38","doi-asserted-by":"publisher","first-page":"5621","DOI":"10.1073\/pnas.090504197","volume":"97","author":"K Zhang","year":"2000","unstructured":"Zhang K, Sejnowski TJ (2000) A universal scaling law between gray matter and white matter of cerebral cortex. Proc Natl Acad Sci USA 97(10):5621\u20135626. https:\/\/doi.org\/10.1073\/pnas.090504197","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"1305_CR39","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/jcbfm.2010.134","volume":"31","author":"RL Zhang","year":"2011","unstructured":"Zhang RL, Chopp M, Roberts C, Jia L, Wei M, Lu M, Wang X, Pourabdollah S, Zhang ZG (2011) Ascl1 lineage cells contribute to ischemia-induced neurogenesis and oligodendrogenesis. J Cereb Blood Flow Metab off J Int Soc Cereb Blood Flow Metab 31(2):614\u2013625. https:\/\/doi.org\/10.1038\/jcbfm.2010.134","journal-title":"J Cereb Blood Flow Metab off J Int Soc Cereb Blood Flow Metab"},{"key":"1305_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.915995","volume":"16","author":"X Zhang","year":"2022","unstructured":"Zhang X, Zhang J (2022) The human brain in a high altitude natural environment: a review. Front Hum Neurosci 16:915995. https:\/\/doi.org\/10.3389\/fnhum.2022.915995","journal-title":"Front Hum Neurosci"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-022-01305-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10571-022-01305-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-022-01305-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T06:48:33Z","timestamp":1687502913000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10571-022-01305-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,10]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["1305"],"URL":"https:\/\/doi.org\/10.1007\/s10571-022-01305-5","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,10]]},"assertion":[{"value":"19 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The animal study was reviewed and approved by the Laboratory Animal Welfare and Ethics Committee of Xiamen University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}