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Importantly, it was indicated as the second cause of disability globally and the leading cause among young women. Despite the widespread prevalence, migraine remains underdiagnosed and undertreated. The possible solution may be microRNAs\u2014small, non-coding molecules. Until now, multiple studies have shown the great value of microRNA in both the diagnosis and treatment of different human diseases. Furthermore, a significant role in neurological disorders has been suggested. Little research regarding the utility of microRNA in migraine has been conducted, however, the results so far appear to be promising. We performed an electronic article search through PubMed and Embase Database to further explore the topic. After the analysis, according to PRISMA 2020 guidelines, we included 21 studies. The dysregulation was observed in migraine in general, as well as in different types and phases; thus, miRNAs emerge as promising diagnostic biomarkers. Additionally, some studies showed the influence of the intervention with miRNA levels on neuroinflammation and the expression of peptides, which are crucial in migraine pathogenesis. This review aims to summarize the current knowledge about the role of miRNAs in migraine and encourage to further research in this field.Kindly check and confirm the edit made in the title.I checked and confirm.\u00a0<\/jats:p>\n                <jats:p><jats:bold>Graphical Abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s10571-023-01387-9","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T13:01:36Z","timestamp":1689080496000},"page":"3315-3327","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Role of MicroRNA in Migraine: A Systemic Literature Review"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4398-675X","authenticated-orcid":false,"given":"Olga","family":"Grodzka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7583-1747","authenticated-orcid":false,"given":"Stanis\u0142aw","family":"S\u0142yk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3130-1036","authenticated-orcid":false,"given":"Izabela","family":"Domitrz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"issue":"1","key":"1387_CR1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s10194-022-01478-w","volume":"23","author":"T Acz\u00e9l","year":"2022","unstructured":"Acz\u00e9l T, Benczik B, \u00c1gg B, K\u00f6rt\u00e9si T, Urb\u00e1n P, Bauer W, Gyenesei A, Tuka B, Tajti J, Ferdinandy P, V\u00e9csei L, B\u00f6lcskei K, Kun J, Helyes Z (2022) Disease- and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: role of inflammatory signalling and oxidative stress. 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