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The mechanisms of ferroptosis were summarized into three interrelated aspects: iron metabolism, lipid peroxide metabolism, as well as glutathione and amino acid metabolism. What\u2019s more, the causal relationship between ferroptosis and IS has been elucidated by several processes. The disruption of the blood\u2013brain barrier, the release of excitatory amino acids, and the inflammatory response after ischemic stroke all lead to the disorder of iron metabolism and the antioxidant system. Based on these statements, we reviewed the reported effects of compounds and drugs treating IS by modulating key molecules in ferroptosis. Through detailed analysis of the roles of these key molecules, we have also more clearly demonstrated the essential effect of ferroptosis in the occurrence of IS so as to provide new targets and ideas for the therapeutic targets of IS.<\/jats:p>\n                <jats:p><jats:bold>Graphical Abstract<\/jats:bold><\/jats:p>\n                <jats:p>Three abnormal cell metabolism pathways contribute to ferroptosis after ischemic stroke, and many key regulatory compounds in ferroptosis can play important therapeutic roles.<\/jats:p>","DOI":"10.1007\/s10571-024-01457-6","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T09:02:22Z","timestamp":1708678942000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9049-0415","authenticated-orcid":false,"given":"Xinjuan","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-0701","authenticated-orcid":false,"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5560-0300","authenticated-orcid":false,"given":"Mengtian","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3413-4539","authenticated-orcid":false,"given":"Lele Zixin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5565-3322","authenticated-orcid":false,"given":"Yunman","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-576X","authenticated-orcid":false,"given":"Weirong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"1457_CR1","doi-asserted-by":"publisher","first-page":"107848","DOI":"10.1016\/j.pharmthera.2021.107848","volume":"225","author":"A Ajoolabady","year":"2021","unstructured":"Ajoolabady A, Wang S, Kroemer G et al (2021) Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics. 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