{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:14:02Z","timestamp":1791432842877,"version":"4.3.3"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s10571-024-01509-x","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T02:02:29Z","timestamp":1730167349000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cognitive Impact of Neurotropic Pathogens: Investigating Molecular Mimicry through Computational Methods"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9366-4225","authenticated-orcid":false,"given":"Pascal","family":"B\u00fcttiker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Boukherissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-9884","authenticated-orcid":false,"given":"Simon","family":"Weissenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1076-2506","authenticated-orcid":false,"given":"Radek","family":"Ptacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3039-3266","authenticated-orcid":false,"given":"Martin","family":"Anders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-1497","authenticated-orcid":false,"given":"Jiri","family":"Raboch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8146-0740","authenticated-orcid":false,"given":"George B.","family":"Stefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"issue":"6","key":"1509_CR1","doi-asserted-by":"publisher","first-page":"6719","DOI":"10.1021\/acs.chemrev.1c00774","volume":"122","author":"A Abyzov","year":"2022","unstructured":"Abyzov A, Blackledge M, Zweckstetter M (2022) Conformational dynamics of intrinsically disordered proteins regulate biomolecular condensate chemistry. Chem Rev 122(6):6719\u20136748. https:\/\/doi.org\/10.1021\/acs.chemrev.1c00774","journal-title":"Chem Rev"},{"issue":"3","key":"1509_CR2","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/s0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215(3):403\u2013410. https:\/\/doi.org\/10.1016\/s0022-2836(05)80360-2","journal-title":"J Mol Biol"},{"key":"1509_CR3","doi-asserted-by":"publisher","unstructured":"Andreou D, J\u00f8rgensen KN, Nerland S, Ueland T, Vaskinn A, Haukvik UK, Yolken RH, Andreassen OA, Agartz I (2022) Herpes simplex virus 1 infection on grey matter and general intelligence in severe mental illness. Transl Psych 12(1). https:\/\/doi.org\/10.1038\/s41398-022-02044-3","DOI":"10.1038\/s41398-022-02044-3"},{"issue":"12","key":"1509_CR4","doi-asserted-by":"publisher","first-page":"6967","DOI":"10.4049\/jimmunol.162.12.6967","volume":"162","author":"CA Benedict","year":"1999","unstructured":"Benedict CA, Butrovich KD, Lurain NS, Corbeil J, Rooney I, Schneider P, Tschopp J, Ware CF (1999) Cutting edge: a novel viral TNF receptor superfamily member in virulent strains of human cytomegalovirus. J Immunol 162(12):6967\u20136970. https:\/\/doi.org\/10.4049\/jimmunol.162.12.6967","journal-title":"J Immunol"},{"issue":"3","key":"1509_CR5","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2174\/157015908785777238","volume":"6","author":"M Berthold-Losleben","year":"2008","unstructured":"Berthold-Losleben M, Himmerich H (2008) The TNF-alpha; system: functional aspects in depression. Narcolepsy Psychopharmacol Curr Neuropharm 6(3):193\u2013202. https:\/\/doi.org\/10.2174\/157015908785777238","journal-title":"Narcolepsy Psychopharmacol Curr Neuropharm"},{"issue":"27","key":"1509_CR6","doi-asserted-by":"publisher","first-page":"10519","DOI":"10.1074\/jbc.ra119.009199","volume":"294","author":"A Bitra","year":"2019","unstructured":"Bitra A, Nem\u010dovi\u010dov\u00e1 I, Picarda G, Doukov T, Wang J, Benedict CA, Zajonc DM (2019) Structure of human cytomegalovirus UL144, an HVEM orthologue, bound to the B and T cell lymphocyte attenuator. J Biol Chem 294(27):10519\u201310529. https:\/\/doi.org\/10.1074\/jbc.ra119.009199","journal-title":"J Biol Chem"},{"key":"1509_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2022.102526","volume":"78","author":"N Borkakoti","year":"2023","unstructured":"Borkakoti N, Thornton JM (2023) AlphaFold2 protein structure prediction: implications for drug discovery. Curr Opin Struct Biol 78:102526. https:\/\/doi.org\/10.1016\/j.sbi.2022.102526","journal-title":"Curr Opin Struct Biol"},{"key":"1509_CR8","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41467-023-44288-7","volume":"15","author":"H Bret","year":"2024","unstructured":"Bret H, Gao J, Zea DJ, Andreani J, Guerois R (2024) From interaction networks to interfaces, scanning intrinsically disordered regions using AlphaFold2. Nat Commun 15:597. https:\/\/doi.org\/10.1038\/s41467-023-44288-7","journal-title":"Nat Commun"},{"key":"1509_CR9","doi-asserted-by":"publisher","unstructured":"B\u00fcttiker P, Weissenberger S, Esch T, Anders M, Raboch J, Ptacek R, Kream RM, Stefano GB (2023) Dysfunctional mitochondrial processes contribute to energy perturbations in the brain and neuropsychiatric symptoms. Front Pharmacol 13. https:\/\/doi.org\/10.3389\/fphar.2022.1095923","DOI":"10.3389\/fphar.2022.1095923"},{"issue":"37","key":"1509_CR10","doi-asserted-by":"publisher","first-page":"13218","DOI":"10.1073\/pnas.0506172102","volume":"102","author":"TC Cheung","year":"2005","unstructured":"Cheung TC, Humphreys IR, Potter KG, Norris PS, Shumway HM, Tran BR, Patterson G, Jean-Jacques R, Yoon M, Spear PG, Murphy KM, Lurain NS, Benedict CA, Ware CF (2005) Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. Proc Natl Acad Sci USA 102(37):13218\u201313223. https:\/\/doi.org\/10.1073\/pnas.0506172102","journal-title":"Proc Natl Acad Sci USA"},{"issue":"47","key":"1509_CR11","doi-asserted-by":"publisher","first-page":"39553","DOI":"10.1074\/jbc.M507629200","volume":"280","author":"DM Compaan","year":"2005","unstructured":"Compaan DM, Gonzalez LC, Tom I, Loyet KM, Eaton D, Hymowitz SG (2005) Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex. J Biol Chem 280(47):39553\u201339561. https:\/\/doi.org\/10.1074\/jbc.M507629200","journal-title":"J Biol Chem"},{"issue":"11","key":"1509_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049700","volume":"7","author":"L D\u2019Aiuto","year":"2012","unstructured":"D\u2019Aiuto L, Di Maio R, Heath B, Raimondi G, Milosevic J, Watson AM, Bamne M, Parks WT, Yang L, Lin B, Miki T, Mich-Basso JD, Arav-Boger R, Sibille E, Sabunciyan S, Yolken R, Nimgaonkar V (2012) Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells. PLoS ONE 7(11):e49700. https:\/\/doi.org\/10.1371\/journal.pone.0049700","journal-title":"PLoS ONE"},{"issue":"8","key":"1509_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000003","volume":"16","author":"S Duffy","year":"2018","unstructured":"Duffy S (2018) Why are RNA virus mutation rates so damn high? PLoS Biol 16(8):e3000003. https:\/\/doi.org\/10.1371\/journal.pbio.3000003","journal-title":"PLoS Biol"},{"key":"1509_CR14","doi-asserted-by":"publisher","DOI":"10.1101\/2021.10.04.463034","author":"R Evans","year":"2021","unstructured":"Evans R, O\u2019Neill M, Pritzel A, Antropova N, Senior A, Green T et al (2021) Protein complex prediction with AlphaFold-multimer. BioRxiv. https:\/\/doi.org\/10.1101\/2021.10.04.463034","journal-title":"BioRxiv"},{"key":"1509_CR15","doi-asserted-by":"publisher","unstructured":"Gligorijevi\u0107 V, Renfrew PD, Kosciolek T, Leman JK, Berenberg D, Vatanen T, Chandler C, Taylor BC, Fisk IM, Vlamakis H, Xavier RJ, Knight R, Cho K, Bonneau R (2021) Structure-based protein function prediction using graph convolutional networks. Nat Commun 12(1). https:\/\/doi.org\/10.1038\/s41467-021-23303-9","DOI":"10.1038\/s41467-021-23303-9"},{"key":"1509_CR16","doi-asserted-by":"publisher","unstructured":"Gomes PSFC, Gomes DEB, Bernardi RC (2022) Protein structure prediction in the era of AI: Challenges and limitations when applying to in silico force spectroscopy. Front Bioinform 2. https:\/\/doi.org\/10.3389\/fbinf.2022.983306","DOI":"10.3389\/fbinf.2022.983306"},{"issue":"2","key":"1509_CR17","doi-asserted-by":"publisher","first-page":"211","DOI":"10.4103\/1673-5374.226380","volume":"13","author":"J Hogestyn","year":"2018","unstructured":"Hogestyn J, Mock D, Mayer-Proschel M (2018) Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human herpesvirus 6 to neurodegenerative disease pathology. Neural Regen Res 13(2):211. https:\/\/doi.org\/10.4103\/1673-5374.226380","journal-title":"Neural Regen Res"},{"issue":"W1","key":"1509_CR18","doi-asserted-by":"publisher","first-page":"W210","DOI":"10.1093\/nar\/gkac387","volume":"50","author":"L Holm","year":"2022","unstructured":"Holm L (2022) Dali server: structural unification of protein families. Nucl Acids Res 50(W1):W210\u2013W215. https:\/\/doi.org\/10.1093\/nar\/gkac387","journal-title":"Nucl Acids Res"},{"issue":"23","key":"1509_CR19","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1093\/bioinformatics\/btn507","volume":"24","author":"L Holm","year":"2008","unstructured":"Holm L, K\u00e4\u00e4ri\u00e4inen S, Rosenstr\u00f6m P, Schenkel A (2008) Searching protein structure databases with DaliLite vol 3. Bioinformatics 24(23):2780\u20132781. https:\/\/doi.org\/10.1093\/bioinformatics\/btn507","journal-title":"Bioinformatics"},{"key":"1509_CR20","doi-asserted-by":"publisher","unstructured":"Jaswal K, Todd OA, Behnsen J (2023) Neglected gut microbiome: interactions of the non-bacterial gut microbiota with enteric pathogens. Gut Microbes 15(1). https:\/\/doi.org\/10.1080\/19490976.2023.2226916","DOI":"10.1080\/19490976.2023.2226916"},{"key":"1509_CR21","doi-asserted-by":"publisher","unstructured":"Jeppesen M, Andr\u00e9 I (2023) Accurate prediction of protein assembly structure by combining AlphaFold and symmetrical docking. Nat Commun 14(1). https:\/\/doi.org\/10.1038\/s41467-023-43681-6","DOI":"10.1038\/s41467-023-43681-6"},{"key":"1509_CR22","doi-asserted-by":"publisher","unstructured":"Johansson-\u00c5khe I, Wallner B (2022) Improving peptide-protein docking with AlphaFold-Multimer using forced sampling. Front Bioinform 2. https:\/\/doi.org\/10.3389\/fbinf.2022.959160","DOI":"10.3389\/fbinf.2022.959160"},{"issue":"7578","key":"1509_CR23","doi-asserted-by":"publisher","first-page":"S178","DOI":"10.1038\/nature16033","volume":"527","author":"CC John","year":"2015","unstructured":"John CC, Carabin H, Montano SM, Bangirana P, Zunt JR, Peterson PK (2015) Global research priorities for infections that affect the nervous system. Nature 527(7578):S178\u2013S186. https:\/\/doi.org\/10.1038\/nature16033","journal-title":"Nature"},{"issue":"1","key":"1509_CR24","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/1471-2164-8-222","volume":"8","author":"T Joshi","year":"2007","unstructured":"Joshi T, Xu D (2007) Quantitative assessment of relationship between sequence similarity and function similarity. BMC Genomics 8(1):222. https:\/\/doi.org\/10.1186\/1471-2164-8-222","journal-title":"BMC Genomics"},{"issue":"7873","key":"1509_CR25","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","volume":"596","author":"J Jumper","year":"2021","unstructured":"Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, Tunyasuvunakool K, Bates R, \u017d\u00eddek A, Potapenko A, Bridgland A, Meyer C, Kohl S, Ballard AJ, Cowie A, Romera-Paredes B, Nikolov S, Jain R, Adler J, Back T, Petersen S, Reiman D, Clancy E, Zielinski M, Steinegger M, Pacholska M, Berghammer T, Bodenstein S, Silver D, Vinyals O, W A Senior, Kavukcuoglu K, Kohli P, Hassabis D (2021) Highly accurate protein structure prediction with AlphaFold. Nature 596(7873):583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2","journal-title":"Nature"},{"issue":"2","key":"1509_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001014","volume":"9","author":"CA Kerfeld","year":"2011","unstructured":"Kerfeld CA, Scott KM (2011) Using BLAST to teach \u201cE-value-tionary\u201d concepts. PLoS Biol 9(2):e1001014. https:\/\/doi.org\/10.1371\/journal.pbio.1001014","journal-title":"PLoS Biol"},{"key":"1509_CR27","doi-asserted-by":"publisher","unstructured":"Kim Y, Kim S (2023) Target discovery using deep learning-based molecular docking and predicted protein structures with AlphaFold for novel antipsychotics. Psych Invest 20(6):504\u2013514. https:\/\/doi.org\/10.30773\/pi.2022.0343","DOI":"10.30773\/pi.2022.0343"},{"issue":"7900","key":"1509_CR28","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41586-022-04432-7","volume":"603","author":"TV Lanz","year":"2022","unstructured":"Lanz TV, Brewer RC, Ho PP, Moon JS, Jude KM, Fernandez D et al (2022) Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM. Nature 603(7900):321\u2013327. https:\/\/doi.org\/10.1038\/s41586-022-04432-7","journal-title":"Nature"},{"key":"1509_CR29","doi-asserted-by":"publisher","unstructured":"Laurikainen H, Vuorela A, Toivonen A, Reinert-Hartwall L, Trontti K, Lindgren M, Kein\u00e4nen J, M\u00e4ntyl\u00e4 T, Paju J, Ilonen T, Armio R-L, Walta M, Tuisku J, Helin S, Marjam\u00e4ki P, Hovatta I, Therman S, Vaarala O, Linnaranta O, Kiesepp\u00e4 T, Salokangas RKR, Honkanen J, Hietala J, Suvisaari J (2020) Elevated serum chemokine CCL22 levels in first-episode psychosis: associations with symptoms, peripheral immune state and in vivo brain glial cell function. Transl Psych 10(1). https:\/\/doi.org\/10.1038\/s41398-020-0776-z","DOI":"10.1038\/s41398-020-0776-z"},{"issue":"9","key":"1509_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001392","volume":"19","author":"TP Light","year":"2021","unstructured":"Light TP, Brun D, Guardado-Calvo P, Pederzoli R, Haouz A, Neipel F, Rey FA, Hristova K, Backovic M (2021) Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling. PloS Biol 19(9):e3001392. https:\/\/doi.org\/10.1371\/journal.pbio.3001392","journal-title":"PloS Biol"},{"issue":"22","key":"1509_CR31","doi-asserted-by":"publisher","first-page":"8421","DOI":"10.3390\/ijms21228421","volume":"21","author":"C Marogianni","year":"2020","unstructured":"Marogianni C, Sokratous M, Dardiotis E, Hadjigeorgiou GM, Bogdanos D, Xiromerisiou G (2020) Neurodegeneration and Inflammation\u2014an interesting interplay in Parkinson\u2019s Disease. Int J Mol Sci 21(22):8421. https:\/\/doi.org\/10.3390\/ijms21228421","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1509_CR32","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1743-422x-6-4","volume":"6","author":"M Miller-Kittrell","year":"2009","unstructured":"Miller-Kittrell M, Sparer TE (2009) Feeling manipulated: cytomegalovirus immune manipulation. Virol J 6(1):4. https:\/\/doi.org\/10.1186\/1743-422x-6-4","journal-title":"Virol J"},{"key":"1509_CR33","doi-asserted-by":"publisher","DOI":"10.1101\/2024.03.16.585347","author":"V Mischley","year":"2024","unstructured":"Mischley V, Maier J, Chen J, Karanicolas J (2024) PPIscreenML: structure-based screening for protein-protein interactions using AlphaFold. BioRxiv (Cold Spring Harbor Laboratory). https:\/\/doi.org\/10.1101\/2024.03.16.585347","journal-title":"BioRxiv (Cold Spring Harbor Laboratory)"},{"issue":"3","key":"1509_CR34","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/s0092-8674(00)81363-x","volume":"87","author":"RI Montgomery","year":"1996","unstructured":"Montgomery RI, Warner MS, Lum BJ, Spear PG (1996) Herpes Simplex Virus-1 entry into cells mediated by a novel member of the TNF\/NGF receptor family. Cell 87(3):427\u2013436. https:\/\/doi.org\/10.1016\/s0092-8674(00)81363-x","journal-title":"Cell"},{"key":"1509_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.654960","volume":"12","author":"Z Ning","year":"2021","unstructured":"Ning Z, Liu K, Xiong H (2021) Roles of BTLA in immunity and immune disorders. Front Immunol 12:654960. https:\/\/doi.org\/10.3389\/fimmu.2021.654960","journal-title":"Front Immunol"},{"issue":"10","key":"1509_CR36","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1021\/ar800064f","volume":"41","author":"JS Nowick","year":"2008","unstructured":"Nowick JS (2008) Exploring \u03b2-sheet structure and interactions with chemical model systems. Acct Chem Res 41(10):1319\u20131330. https:\/\/doi.org\/10.1021\/ar800064f","journal-title":"Acct Chem Res"},{"key":"1509_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2022.102230","volume":"70","author":"E Pfeifer","year":"2022","unstructured":"Pfeifer E, Sousa JM, Touchon M, Rocha EP (2022) When bacteria are phage playgrounds: interactions between viruses, cells, and mobile genetic elements. Curr Opin Microbiol 70:102230. https:\/\/doi.org\/10.1016\/j.mib.2022.102230","journal-title":"Curr Opin Microbiol"},{"key":"1509_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2022.102501","volume":"78","author":"LM Pietrek","year":"2023","unstructured":"Pietrek LM, Stelzl LS, Hummer G (2023) Structural ensembles of disordered proteins from hierarchical chain growth and simulation. Curr Opin Struct Biol 78:102501. https:\/\/doi.org\/10.1016\/j.sbi.2022.102501","journal-title":"Curr Opin Struct Biol"},{"issue":"8","key":"1509_CR39","doi-asserted-by":"publisher","first-page":"4261","DOI":"10.1128\/jvi.03497-12","volume":"87","author":"E Poole","year":"2013","unstructured":"Poole E, Walther A, Raven K, Benedict CA, Mason GM, Sinclair J (2013) The myeloid transcription factor GATA-2 regulates the Viral UL144 Gene during Human Cytomegalovirus latency in an isolate-specific manner. J Virol 87(8):4261\u20134271. https:\/\/doi.org\/10.1128\/jvi.03497-12","journal-title":"J Virol"},{"key":"1509_CR40","doi-asserted-by":"publisher","unstructured":"Reale M, Costantini E, Greig NH (2021) Cytokine imbalance in schizophrenia. From research to clinic: Potential implications for treatment. Front Psych 12. https:\/\/doi.org\/10.3389\/fpsyt.2021.536257","DOI":"10.3389\/fpsyt.2021.536257"},{"issue":"1","key":"1509_CR41","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1146\/annurev-pathol-052920-040318","volume":"17","author":"S Rodriguez Mur\u00faa","year":"2022","unstructured":"Rodriguez Mur\u00faa S, Farez MF, Quintana FJ (2022) The immune response in multiple sclerosis. Ann Rev Pathol Mech Dis 17(1):121\u2013139. https:\/\/doi.org\/10.1146\/annurev-pathol-052920-040318","journal-title":"Ann Rev Pathol Mech Dis"},{"key":"1509_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2023.106018","volume":"176","author":"S Sankar","year":"2023","unstructured":"Sankar S, Dhakshinamoorthy V, Rajakumar G (2023) PARP in the neuropathogenesis of cytomegalovirus infection\u2014possible role and therapeutic perspective. Microb Pathog 176:106018. https:\/\/doi.org\/10.1016\/j.micpath.2023.106018","journal-title":"Microb Pathog"},{"issue":"51","key":"1509_CR43","doi-asserted-by":"publisher","first-page":"21060","DOI":"10.1074\/jbc.m117.813295","volume":"292","author":"JR \u0160ed\u00fd","year":"2017","unstructured":"\u0160ed\u00fd JR, Balmert MO, Ware BC, Smith W, Nem\u010dovi\u010dova I, Norris PS, Miller BR, Aivazian D, Ware CF (2017) A herpesvirus entry mediator mutein with selective agonist action for the inhibitory receptor B and T lymphocyte attenuator. J Biol Chem 292(51):21060\u201321070. https:\/\/doi.org\/10.1074\/jbc.m117.813295","journal-title":"J Biol Chem"},{"issue":"4","key":"1509_CR44","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1189\/jlb.0910528","volume":"89","author":"J-W Shui","year":"2011","unstructured":"Shui J-W, Steinberg MW, Kronenbery M (2011) Regulation of inflammation, autoimmunity, and infection immunity by HVEM-BTLA signaling. J Leukoc Biol 89(4):517\u2013523. https:\/\/doi.org\/10.1189\/jlb.0910528","journal-title":"J Leukoc Biol"},{"issue":"1","key":"1509_CR45","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41579-022-00770-5","volume":"21","author":"SS Soldan","year":"2023","unstructured":"Soldan SS, Lieberman PM (2023) Epstein-Barr virus and multiple sclerosis. Nat Rev Microbiol 21(1):51\u201364. https:\/\/doi.org\/10.1038\/s41579-022-00770-5","journal-title":"Nat Rev Microbiol"},{"key":"1509_CR46","first-page":"271","volume-title":"CRC Handbook of comparative opioid and related neuropeptide mechanisms","author":"GB Stefano","year":"1986","unstructured":"Stefano GB (1986) Conformational matching: a possible evolutionary force in the evolvement of signal systems. In: Stefano GB (ed) CRC Handbook of comparative opioid and related neuropeptide mechanisms. CRC Press, Boca Raton, pp 271\u2013277"},{"key":"1509_CR47","doi-asserted-by":"publisher","unstructured":"Stefano GB, Kream RM (2017) Artificial intelligence, DNA mimicry, and human health. Medical Sci Monitor 23:3923\u20133924. https:\/\/doi.org\/10.12659\/msm.906498","DOI":"10.12659\/msm.906498"},{"key":"1509_CR48","doi-asserted-by":"publisher","unstructured":"Stefano GB, B\u00fcttiker P, Weissenberger S, Esch T, Anders M, Raboch J, Kream RM, Ptacek R (2023) Independent and sensory human mitochondrial functions reflecting symbiotic evolution. Front Cell Infect Microbiol 13. https:\/\/doi.org\/10.3389\/fcimb.2023.1130197","DOI":"10.3389\/fcimb.2023.1130197"},{"issue":"2","key":"1509_CR49","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/s41587-023-01773-0","volume":"42","author":"M Van Kempen","year":"2023","unstructured":"Van Kempen M, Kim SS, Tumescheit C, Mirdita M, Lee J, Gilchrist CLM, S\u00f6ding J, Steinegger M (2023) Fast and accurate protein structure search with Foldseek. Nat Biotechnol 42(2):243\u2013246. https:\/\/doi.org\/10.1038\/s41587-023-01773-0","journal-title":"Nat Biotechnol"},{"issue":"D1","key":"1509_CR50","doi-asserted-by":"publisher","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","volume":"50","author":"M Varadi","year":"2021","unstructured":"Varadi M, Anyango S, Deshpande M, Nair S, Natassia C, Yordanova G, Yuan D, Stroe O, Wood G, Laydon A, \u017d\u00eddek A, Green T, Tunyasuvunakool K, Petersen S, Jumper J, Clancy E, Green R, Vora A, Lutfi M, Figurnov M, Cowie A, Hobbs N, Kohli P, Kleywegt G, Birney E, Hassabis D, Velankar S (2021) AlphaFold protein structure database: massively expanding the structural coverage of protein-sequence space with high-accuracy models. Nucl Acids Res 50(D1):D439\u2013D444. https:\/\/doi.org\/10.1093\/nar\/gkab1061","journal-title":"Nucl Acids Res"},{"key":"1509_CR51","doi-asserted-by":"publisher","unstructured":"Wallner B (2023) AFsample: improving multimer prediction with AlphaFold using massive sampling. Bioinformatics 39(9):btad573. https:\/\/doi.org\/10.1093\/bioinformatics\/btad573.","DOI":"10.1093\/bioinformatics\/btad573"},{"key":"1509_CR52","doi-asserted-by":"publisher","unstructured":"Wang F, Kream RM, Stefano GB (2020) Long-Term respiratory and neurological sequelae of COVID-19. Med Sci Monit 26. https:\/\/doi.org\/10.12659\/msm.928996","DOI":"10.12659\/msm.928996"},{"issue":"7","key":"1509_CR57","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1093\/bioinformatics\/btq066","volume":"26","author":"J Xu","year":"2010","unstructured":"Xu J, Zhang Y (2010) How significant is a protein structure similarity with TM-score = 0.5? Bioinformatics 26(7):889\u2013895. https:\/\/doi.org\/10.1093\/bioinformatics\/btq066","journal-title":"Bioinformatics"},{"issue":"10","key":"1509_CR53","doi-asserted-by":"publisher","first-page":"4584","DOI":"10.3390\/cimb44100314","volume":"44","author":"P Yadav","year":"2022","unstructured":"Yadav P, Lee Y-H, Panday H, Kant S, Bajwa N, Parashar R, Jha SK, Jha NK, Nand P, Lee S-S, Jha AK (2022) Implications of microorganisms in Alzheimer\u2019s disease. Curr Issues Mol Biol 44(10):4584\u20134615. https:\/\/doi.org\/10.3390\/cimb44100314","journal-title":"Curr Issues Mol Biol"},{"issue":"9","key":"1509_CR54","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/s41592-022-01585-1","volume":"19","author":"C Zhang","year":"2022","unstructured":"Zhang C, Shine M, Pyle AM, Zhang Y (2022) US-align: universal structure alignments of proteins, nucleic acids, and macromolecular complexes. Nat Methods 19(9):1109\u20131115. https:\/\/doi.org\/10.1038\/s41592-022-01585-1","journal-title":"Nat Methods"},{"issue":"7","key":"1509_CR58","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1093\/nar\/gki524","volume":"33","author":"Y Zhang","year":"2005","unstructured":"Zhang Y, Skolnick J (2005) TM-align: a protein structure alignment algorithm based on the TM-score. Nucleic Acids Res 33(7):2302\u20132309. https:\/\/doi.org\/10.1093\/nar\/gki524","journal-title":"Nucleic Acids Res"},{"key":"1509_CR55","doi-asserted-by":"publisher","unstructured":"Zheng H, Ford BN, Kuplicki R, Burrows K, Hunt PW, Bodurka J, Teague TK, Irwin MR, Yolken RH, Paulus MP, Savitz J (2021) Association between cytomegalovirus infection, reduced gray matter volume, and resting-state functional hypoconnectivity in major depressive disorder: a replication and extension. Transl Psych 11(1). https:\/\/doi.org\/10.1038\/s41398-021-01558-6","DOI":"10.1038\/s41398-021-01558-6"},{"issue":"1","key":"1509_CR56","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/s41386-023-01674-5","volume":"49","author":"H Zheng","year":"2023","unstructured":"Zheng H, Savitz J (2023) Herpesviruses and neuropsychiatric disorders: overlooked adversaries or innocent bystanders? Neuropsychopharm 49(1):313\u2013314. https:\/\/doi.org\/10.1038\/s41386-023-01674-5","journal-title":"Neuropsychopharm"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-024-01509-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10571-024-01509-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-024-01509-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T11:12:10Z","timestamp":1734174730000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10571-024-01509-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,29]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["1509"],"URL":"https:\/\/doi.org\/10.1007\/s10571-024-01509-x","relation":{},"ISSN":["0272-4340","1573-6830"],"issn-type":[{"value":"0272-4340","type":"print"},{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,29]]},"assertion":[{"value":"2 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}],"article-number":"72"}}