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Given the increasing global life expectancy, there is an urgent need for effective strategies to prevent and manage Alzheimer\u2019s disease, with a particular focus on anti-aging interventions. Recent scientific advancements have unveiled several promising strategies for combating Alzheimer\u2019s disease (AD), ranging from lifestyle interventions to cutting-edge pharmacological treatments and therapies targeting the underlying biological processes of aging and AD. Regular physical exercise, cognitive engagement, a balanced diet, and social interaction serve as key pillars in maintaining brain health. At the same time, therapies target key pathological mechanisms of AD, such as amyloid-beta accumulation, tau abnormalities, neuroinflammation, mitochondrial dysfunction, and synaptic loss, offering potential breakthroughs in treatment. Moreover, cutting-edge innovations such as gene therapy, stem cell transplantation, and novel drug delivery systems are emerging as potential game-changers in the fight against AD. This review critically evaluates the latest research on anti-aging interventions and their potential in preventing and treating Alzheimer\u2019s disease (AD) by exploring the connections between aging mechanisms and AD pathogenesis. It provides a comprehensive analysis of both well-established and emerging strategies, while also identifying key gaps in current knowledge to guide future research efforts.<\/jats:p>","DOI":"10.1007\/s10571-024-01514-0","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T08:04:41Z","timestamp":1732781081000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Molecular and Cellular Foundations of Aging of the Brain: Anti-aging Strategies in Alzheimer\u2019s Disease"],"prefix":"10.1007","volume":"44","author":[{"given":"Magdalena","family":"Dziewa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3276-9404","authenticated-orcid":false,"given":"Magdalena","family":"Z\u0142otek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8975-8093","authenticated-orcid":false,"given":"Mariola","family":"Herbet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1829-6981","authenticated-orcid":false,"given":"Iwona","family":"Pi\u0105tkowska-Chmiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"1514_CR1","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1172\/JCI95145","volume":"128","author":"DJ Baker","year":"2018","unstructured":"Baker DJ, Petersen RC (2018) Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives. 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