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The impactor adopted in the study is currently being patented by SISSA and is available upon request. The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"The study was performed in line with the principles of the Italian Animal Welfare Act 24\/3\/2014 n. 26 implementing the European Union directive on animal experimentation (2010\/63\/ EU). The study complied with the ARRIVE guidelines. The animal protocol was approved by the Italian Ministry of Health with the notification. 22DAB.N.52\u00a0M dated Oct 30th, 2019, and approved by SISSA ACUC (OPBA) committee (verbale n.17\/3019).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All authors give their formal consent to participate to the present manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors give their formal consent for the publication of the present manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"This manuscript was previously published as a pre-print on bioRxiv, available at\n                      \n                      , on 17 July 2024.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Preprint Disclosure Statement"}}],"article-number":"10"}}