{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:28:55Z","timestamp":1793759335570,"version":"4.6.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["BSC0115-miND"],"award-info":[{"award-number":["BSC0115-miND"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["BSC0115-miND"],"award-info":[{"award-number":["BSC0115-miND"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/4-5\/3\/17\/Neuro\/2022-NCD-1"],"award-info":[{"award-number":["5\/4-5\/3\/17\/Neuro\/2022-NCD-1"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"DOI":"10.1007\/s10571-025-01547-z","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T02:36:16Z","timestamp":1743215776000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Investigating Molecular Mechanisms in Ischemic Preconditioning-Induced Resiliency to Severe Acute Global Cerebral Ischemia Using a Mouse Model of Chronic Cerebral Hypoperfusion"],"prefix":"10.1007","volume":"45","author":[{"given":"Roli","family":"Kushwaha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashikant","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. S.","family":"Yuvaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumana","family":"Chakravarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"1547_CR1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13351","volume":"45","author":"AC Akinmoladun","year":"2021","unstructured":"Akinmoladun AC, Obadaye TS, Olaleye MT, Akindahunsi AA (2021) Prophylaxis with a multicomponent nutraceutical abates transient cerebral ischemia\/reperfusion injury. J Food Biochem 45:e13351","journal-title":"J Food Biochem"},{"key":"1547_CR3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/wcs.1266","volume":"5","author":"JP Bhanji","year":"2014","unstructured":"Bhanji JP, Delgado MR (2014) The social brain and reward: social information processing in the human striatum. Wiley Interdiscip Rev Cogn Sci 5:61\u201373","journal-title":"Wiley Interdiscip Rev Cogn Sci"},{"key":"1547_CR4","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1007\/s11011-022-00995-6","volume":"37","author":"JA Bhat","year":"2022","unstructured":"Bhat JA, Kumar M (2022) Neuroprotective effects of theobromine in permanent bilateral common carotid artery occlusion rat model of cerebral hypoperfusion. Metab Brain Dis 37:1787\u20131801","journal-title":"Metab Brain Dis"},{"key":"1547_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-016-0779-0","volume":"14","author":"BD Bin","year":"2017","unstructured":"Bin BD, Kwon KJ, Choi D-H, Shin CY, Lee J, Han S-H, Kim HY (2017) Chronic cerebral hypoperfusion induces post-stroke dementia following acute ischemic stroke in rats. J Neuroinflamm 14:1\u201312","journal-title":"J Neuroinflamm"},{"key":"1547_CR5","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.neuint.2006.02.011","volume":"49","author":"KK Bowen","year":"2006","unstructured":"Bowen KK, Naylor M, Vemuganti R (2006) Prevention of inflammation is a mechanism of preconditioning-induced neuroprotection against focal cerebral ischemia. Neurochem Int 49:127\u2013135","journal-title":"Neurochem Int"},{"key":"1547_CR6","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/s41420-022-01089-z","volume":"8","author":"P Brancaccio","year":"2022","unstructured":"Brancaccio P, Anzilotti S, Cuomo O, Vinciguerra A, Campanile M, Herchuelz A, Amoroso S, Annunziato L, Pignataro G (2022) Preconditioning in hypoxic\u2013ischemic neonate mice triggers Na+\u2013Ca2+ exchanger-dependent neurogenesis. Cell Death Discov 8:318","journal-title":"Cell Death Discov"},{"key":"1547_CR7","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.expneurol.2016.07.004","volume":"283","author":"L Burnier","year":"2016","unstructured":"Burnier L, Boroujerdi A, Fern\u00e1ndez JA, Welser-Alves JV, Griffin JH, Milner R (2016) Physiological cerebrovascular remodeling in response to chronic mild hypoxia: a role for activated protein C. Exp Neurol 283:396\u2013403","journal-title":"Exp Neurol"},{"issue":"8","key":"1547_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2024.107735","volume":"33","author":"TM Burton","year":"2024","unstructured":"Burton TM, Madsen TE, Karb R, Furie KL (2024) Importance of sex and gender differences in enrollment and interpretation of stroke clinical trials. J Stroke Cerebrovasc Dis 33(8):107735","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"1547_CR9","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1161\/STROKEAHA.115.011679","volume":"47","author":"B-R Choi","year":"2016","unstructured":"Choi B-R, Kim D-H, Bin BD, Kang CH, Moon W-J, Han J-S, Choi D-H, Kwon KJ, Shin CY, Kim B-R (2016) Characterization of white matter injury in a rat model of chronic cerebral hypoperfusion. Stroke 47:542\u2013547","journal-title":"Stroke"},{"key":"1547_CR10","doi-asserted-by":"publisher","first-page":"5177","DOI":"10.1007\/s12035-020-02091-1","volume":"57","author":"T Das","year":"2020","unstructured":"Das T, Soren K, Yerasi M, Kamle A, Kumar A, Chakravarty S (2020) Molecular basis of sex difference in neuroprotection induced by hypoxia preconditioning in zebrafish. Mol Neurobiol 57:5177\u20135192","journal-title":"Mol Neurobiol"},{"key":"1547_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.110210","volume":"109","author":"RP de Aguiar","year":"2021","unstructured":"de Aguiar RP, Newman-Tancredi A, Prickaerts J, de Oliveira RMW (2021) The 5-HT1A receptor as a serotonergic target for neuroprotection in cerebral ischemia. Prog Neuro-Psychopharmacol Biol Psychiatry 109:110210","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"1547_CR31","doi-asserted-by":"publisher","DOI":"10.1590\/s2175-97902023e21555","volume":"59","author":"EV Dos Santos","year":"2023","unstructured":"Dos Santos EV, de Schirmer BGA, Pereira JM, Cardoso NVS, Malamut C, de Oliveira ML (2023) Applicability of [18F] FDG\/PET for investigating rosmarinic acid preconditioning efficacy in a global stroke model in mice. Braz J Pharm Sci 59:e21555","journal-title":"Braz J Pharm Sci"},{"key":"1547_CR12","doi-asserted-by":"publisher","first-page":"2400088","DOI":"10.1002\/adtp.202400088","volume":"7","author":"Y Du","year":"2024","unstructured":"Du Y, Yan C, Wang Y, Xu Y, Cun X, Gao H (2024) The implication and application of brain glymphatic system in multiple diseases. Adv Ther 7:2400088","journal-title":"Adv Ther"},{"key":"1547_CR13","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.7150\/ijbs.4679","volume":"8","author":"M Erta","year":"2012","unstructured":"Erta M, Quintana A, Hidalgo J (2012) Interleukin-6, a major cytokine in the central nervous system. Int J Biol Sci 8:1254","journal-title":"Int J Biol Sci"},{"key":"1547_CR14","doi-asserted-by":"publisher","first-page":"3141","DOI":"10.1007\/s12035-021-02329-6","volume":"58","author":"X Geng","year":"2021","unstructured":"Geng X, Wang Q, Lee H, Huber C, Wills M, Elkin K, Li F, Ji X, Ding Y (2021) Remote ischemic postconditioning vs. physical exercise after stroke: an alternative rehabilitation strategy? Mol Neurobiol 58:3141\u20133157","journal-title":"Mol Neurobiol"},{"key":"1547_CR15","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s10456-017-9593-2","volume":"21","author":"SK Halder","year":"2018","unstructured":"Halder SK, Kant R, Milner R (2018) Chronic mild hypoxia promotes profound vascular remodeling in spinal cord blood vessels, preferentially in white matter, via an \u03b15\u03b21 integrin-mediated mechanism. Angiogenesis 21:251\u2013266","journal-title":"Angiogenesis"},{"key":"1547_CR16","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1161\/STROKEAHA.124.046400","volume":"55","author":"S Jeong","year":"2024","unstructured":"Jeong S, Chokkalla AK, Davis CK, Jeong H, Chelluboina B, Arruri V, Kim B, Narman A, Bathula S, Arumugam TV (2024) Circadian-dependent intermittent fasting influences ischemic tolerance and dendritic spine remodeling. Stroke 55:2139\u20132150","journal-title":"Stroke"},{"key":"1547_CR17","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1038\/jcbfm.2015.55","volume":"35","author":"Z Jing","year":"2015","unstructured":"Jing Z, Shi C, Zhu L, Xiang Y, Chen P, Xiong Z, Li W, Ruan Y, Huang L (2015) Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment. J Cereb Blood Flow Metab 35:1249\u20131259","journal-title":"J Cereb Blood Flow Metab"},{"key":"1547_CR18","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1161\/hh0701.088842","volume":"88","author":"H Kawata","year":"2001","unstructured":"Kawata H, Yoshida K, Kawamoto A, Kurioka H, Takase E, Sasaki Y, Hatanaka K, Kobayashi M, Ueyama T, Hashimoto T (2001) Ischemic preconditioning upregulates vascular endothelial growth factor mRNA expression and neovascularization via nuclear translocation of protein kinase C \u03b5 in the rat ischemic myocardium. Circ Res 88:696\u2013704","journal-title":"Circ Res"},{"key":"1547_CR19","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0006-8993(01)02801-3","volume":"914","author":"S Kelly","year":"2001","unstructured":"Kelly S, McCulloch J, Horsburgh K (2001) Minimal ischaemic neuronal damage and HSP70 expression in MF1 strain mice following bilateral common carotid artery occlusion. Brain Res 914:185\u2013195","journal-title":"Brain Res"},{"key":"1547_CR20","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.3390\/nu15143271","volume":"15","author":"M-S Kim","year":"2023","unstructured":"Kim M-S, Kim B-Y, Kim JI, Lee J, Jeon WK (2023) Mumefural improves recognition memory and alters ERK-CREB-BDNF signaling in a mouse model of chronic cerebral hypoperfusion. Nutrients 15:3271","journal-title":"Nutrients"},{"key":"1547_CR21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1006\/brcg.2000.1237","volume":"45","author":"R Laforce Jr","year":"2001","unstructured":"Laforce R Jr, Doyon J (2001) Distinct contribution of the striatum and cerebellum to motor learning. Brain Cogn 45:189\u2013211","journal-title":"Brain Cogn"},{"key":"1547_CR22","doi-asserted-by":"publisher","first-page":"5249","DOI":"10.3390\/ijms23095249","volume":"23","author":"D Lee","year":"2022","unstructured":"Lee D, Tomita Y, Yang L, Negishi K, Kurihara T (2022) Ocular ischemic syndrome and its related experimental models. Int J Mol Sci 23:5249","journal-title":"Int J Mol Sci"},{"key":"1547_CR23","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.3390\/cells10092236","volume":"10","author":"J Lier","year":"2021","unstructured":"Lier J, Streit WJ, Bechmann I (2021) Beyond activation: characterizing microglial functional phenotypes. Cells 10:2236","journal-title":"Cells"},{"key":"1547_CR24","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","volume":"74","author":"CE Murry","year":"1986","unstructured":"Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74:1124\u20131136","journal-title":"Circulation"},{"key":"1547_CR25","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/jcbfm.2014.185","volume":"35","author":"JT Neumann","year":"2015","unstructured":"Neumann JT, Thompson JW, Raval AP, Cohan CH, Koronowski KB, Perez-Pinzon MA (2015) Increased BDNF protein expression after ischemic or PKC epsilon preconditioning promotes electrophysiologic changes that lead to neuroprotection. J Cereb Blood Flow Metab 35:121\u2013130","journal-title":"J Cereb Blood Flow Metab"},{"key":"1547_CR26","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s11064-022-03732-8","volume":"48","author":"OB Ojo","year":"2023","unstructured":"Ojo OB, Amoo ZA, Olaleye MT, Jha SK, Akinmoladun AC (2023) Time and brain region-dependent excitatory neurochemical alterations in bilateral common carotid artery occlusion global ischemia model. Neurochem Res 48:96\u2013116","journal-title":"Neurochem Res"},{"key":"1547_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113326","volume":"143","author":"S Patel","year":"2024","unstructured":"Patel S, Govindarajan V, Chakravarty S, Dubey N (2024) From blood to brain: exploring the role of fibrinogen in the pathophysiology of depression and other neurological disorders. Int Immunopharmacol 143:113326","journal-title":"Int Immunopharmacol"},{"key":"1547_CR28","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.neulet.2018.07.021","volume":"689","author":"M Pekny","year":"2019","unstructured":"Pekny M, Wilhelmsson U, Tatlisumak T, Pekna M (2019) Astrocyte activation and reactive gliosis\u2014a new target in stroke? Neurosci Lett 689:45\u201355","journal-title":"Neurosci Lett"},{"key":"1547_CR29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s12017-024-08816-y","volume":"26","author":"M Radhakrishnan","year":"2024","unstructured":"Radhakrishnan M, Undru A, Patel S, Sharma P, Kumar A, Chakravarty S (2024a) Transcriptomic profiling reveals sex-specific epigenetic dynamics involving kdm6b and H3K27 methylation in cerebral ischemia-induced neurogenesis and recovery. Neuromol Med 26:49","journal-title":"Neuromol Med"},{"key":"1547_CR30","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s12017-023-08768-9","volume":"26","author":"M Radhakrishnan","year":"2024","unstructured":"Radhakrishnan M, Vijay V, Supraja Acharya B, Basuthakur P, Patel S, Soren K, Kumar A, Chakravarty S (2024b) Uncovering sex-specific epigenetic regulatory mechanism involving H3k9me2 in neural inflammation, damage, and recovery in the internal carotid artery occlusion mouse model. Neuromol Med 26:3","journal-title":"Neuromol Med"},{"key":"1547_CR32","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/s41593-021-00806-8","volume":"24","author":"RM Shansky","year":"2021","unstructured":"Shansky RM, Murphy AZ (2021) Considering sex as a biological variable will require a global shift in science culture. Nat Neurosci 24:457\u2013464","journal-title":"Nat Neurosci"},{"key":"1547_CR33","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.bbr.2013.04.010","volume":"249","author":"LM Soares","year":"2013","unstructured":"Soares LM, Schiavon AP, Milani H, de Oliveira RMW (2013) Cognitive impairment and persistent anxiety-related responses following bilateral common carotid artery occlusion in mice. Behav Brain Res 249:28\u201337","journal-title":"Behav Brain Res"},{"key":"1547_CR34","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3390\/neuroglia3030007","volume":"3","author":"J Stadler","year":"2022","unstructured":"Stadler J, Schurr H, Doyle D, Garmo L, Srinageshwar B, Spencer MR, Petersen RB, Dunbar GL, Rossignol J (2022) Temporal profile of reactive astrocytes after ischemic stroke in rats. Neuroglia 3:99\u2013111","journal-title":"Neuroglia"},{"key":"1547_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.860959","volume":"15","author":"T Tang","year":"2022","unstructured":"Tang T, Hu L, Liu Y, Fu X, Li J, Yan F, Cao S, Chen G (2022) Sex-associated differences in neurovascular dysfunction during ischemic stroke. Front Mol Neurosci 15:860959","journal-title":"Front Mol Neurosci"},{"key":"1547_CR36","doi-asserted-by":"publisher","first-page":"36758","DOI":"10.1038\/srep36758","volume":"6","author":"K Ueno","year":"2016","unstructured":"Ueno K, Samura M, Nakamura T, Tanaka Y, Takeuchi Y, Kawamura D, Takahashi M, Hosoyama T, Morikage N, Hamano K (2016) Increased plasma VEGF levels following ischemic preconditioning are associated with downregulation of miRNA-762 and miR-3072-5p. Sci Rep 6:36758","journal-title":"Sci Rep"},{"issue":"12","key":"1547_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12035-024-04205-5","volume":"61","author":"SM Varghese","year":"2024","unstructured":"Varghese SM, Patel S, Nandan A, Jose A, Ghosh S, Sah RK, Menon B, Athira KV, Chakravarty S (2024) Unraveling the role of the blood\u2013brain barrier in the pathophysiology of depression: recent advances and future perspectives. Mol Neurobiol 61(12):1\u201350","journal-title":"Mol Neurobiol"},{"key":"1547_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jchemneu.2018.04.006","volume":"92","author":"AB Wahul","year":"2018","unstructured":"Wahul AB, Joshi PC, Kumar A, Chakravarty S (2018) Transient global cerebral ischemia differentially affects cortex, striatum and hippocampus in bilateral common carotid arterial occlusion (BCCAo) mouse model. J Chem Neuroanat 92:1\u201315","journal-title":"J Chem Neuroanat"},{"key":"1547_CR39","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.expneurol.2016.07.006","volume":"283","author":"L Wang","year":"2016","unstructured":"Wang L, Du Y, Wang K, Xu G, Luo S, He G (2016) Chronic cerebral hypoperfusion induces memory deficits and facilitates A\u03b2 generation in C57BL\/6J mice. Exp Neurol 283:353\u2013364","journal-title":"Exp Neurol"},{"key":"1547_CR40","doi-asserted-by":"publisher","first-page":"227","DOI":"10.2217\/fnl.10.1","volume":"5","author":"JR Weinstein","year":"2009","unstructured":"Weinstein JR, Koerner IP, M\u00f6ller T (2009) Microglia in ischemic brain injury. Future Neurol 5:227\u2013246","journal-title":"Future Neurol"},{"key":"1547_CR41","doi-asserted-by":"publisher","first-page":"105155","DOI":"10.1016\/j.neuint.2021.105155","volume":"150","author":"F Xiao","year":"2021","unstructured":"Xiao F, Zhang X, Ni P, Yu H, Gao Q, Li M, Huo P, Wei Z, Wang S, Zhang Y (2021) Voltage-dependent potassium channel Kv4.2 alleviates the ischemic stroke impairments through activating neurogenesis. Neurochem Int 150:105155","journal-title":"Neurochem Int"},{"key":"1547_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.113142","volume":"325","author":"T Yang","year":"2020","unstructured":"Yang T, Sun Y, Li Q, Li S, Shi Y, Leak RK, Chen J, Zhang F (2020) Ischemic preconditioning provides long-lasting neuroprotection against ischemic stroke: the role of Nrf2. Exp Neurol 325:113142","journal-title":"Exp Neurol"},{"key":"1547_CR43","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s10571-014-0127-9","volume":"35","author":"Y Zhao","year":"2015","unstructured":"Zhao Y, Gong C-X (2015) From chronic cerebral hypoperfusion to Alzheimer-like brain pathology and neurodegeneration. Cell Mol Neurobiol 35:101\u2013110","journal-title":"Cell Mol Neurobiol"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-025-01547-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10571-025-01547-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-025-01547-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:02:13Z","timestamp":1765537333000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10571-025-01547-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1547"],"URL":"https:\/\/doi.org\/10.1007\/s10571-025-01547-z","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5804657\/v1","asserted-by":"object"}]},"ISSN":["1573-6830"],"issn-type":[{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,26]]},"assertion":[{"value":"10 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal procedures were approved by the Institutional Animal Ethics Committee, 20\/GO\/RBi\/99\/CPCSEA at the Centre for Cellular and Molecular Biology, Hyderabad, India.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}],"article-number":"27"}}