{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T08:40:18Z","timestamp":1794559218696,"version":"4.9.1"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82271453"],"award-info":[{"award-number":["82271453"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"DOI":"10.1007\/s10571-025-01575-9","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T07:16:17Z","timestamp":1748502977000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Endoplasmic Reticulum Stress Inhibition Promotes Mitophagy via Miro1 Reduction to Rescue Mitochondrial Dysfunction and Protect Dopamine Neurons in Parkinson\u2019s Disease"],"prefix":"10.1007","volume":"45","author":[{"given":"Yuqi","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xvshen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangni","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"1575_CR1","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.bbi.2020.09.017","volume":"91","author":"S Ahmed","year":"2021","unstructured":"Ahmed S, Kwatra M, Ranjan Panda S et al (2021) Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease. Brain Behav Immun 91:142\u2013158. https:\/\/doi.org\/10.1016\/j.bbi.2020.09.017","journal-title":"Brain Behav Immun"},{"key":"1575_CR2","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0140-6736(23)01419-8","volume":"403","author":"Y Ben-Shlomo","year":"2024","unstructured":"Ben-Shlomo Y, Darweesh S, Llibre-Guerra J et al (2024) The epidemiology of Parkinson\u2019s disease. Lancet 403:283\u2013292. https:\/\/doi.org\/10.1016\/S0140-6736(23)01419-8","journal-title":"Lancet"},{"key":"1575_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1083\/jcb.2.4.73","volume":"2","author":"W Bernhard","year":"1956","unstructured":"Bernhard W, Rouiller C (1956) Close topographical relationship between mitochondria and ergastoplasm of liver cells in a definite phase of cellular activity. J Biophys Biochem Cytol 2:73\u201378. https:\/\/doi.org\/10.1083\/jcb.2.4.73","journal-title":"J Biophys Biochem Cytol"},{"key":"1575_CR4","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","volume":"397","author":"BR Bloem","year":"2021","unstructured":"Bloem BR, Okun MS, Klein C (2021) Parkinson\u2019s disease. Lancet 397:2284\u20132303. https:\/\/doi.org\/10.1016\/S0140-6736(21)00218-X","journal-title":"Lancet"},{"key":"1575_CR5","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.immuni.2015.08.008","volume":"43","author":"DN Bronner","year":"2015","unstructured":"Bronner DN, Abuaita BH, Chen X et al (2015) Endoplasmic reticulum stress activates the inflammasome via NLRP3- and caspase-2-driven mitochondrial damage. Immunity 43:451\u2013462. https:\/\/doi.org\/10.1016\/j.immuni.2015.08.008","journal-title":"Immunity"},{"key":"1575_CR6","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1080\/15548627.2015.1121360","volume":"12","author":"Y Cai","year":"2016","unstructured":"Cai Y, Arikkath J, Yang L et al (2016) Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders. Autophagy 12:225\u2013244. https:\/\/doi.org\/10.1080\/15548627.2015.1121360","journal-title":"Autophagy"},{"key":"1575_CR7","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s13020-024-01029-2","volume":"19","author":"T Cao","year":"2024","unstructured":"Cao T, Wang X, Rao J et al (2024) Periplaneta americana L. extract exerts neuroprotective effects by inhibiting endoplasmic reticulum stress via AKT-dependent pathway in experimental models of Parkinson\u2019s disease. Chin Med 19:157. https:\/\/doi.org\/10.1186\/s13020-024-01029-2","journal-title":"Chin Med"},{"key":"1575_CR8","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1016\/j.neurobiolaging.2015.05.018","volume":"36","author":"L Chen","year":"2015","unstructured":"Chen L, Na R, Boldt E, Ran Q (2015) NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure. Neurobiol Aging 36:2533\u20132543. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.05.018","journal-title":"Neurobiol Aging"},{"key":"1575_CR9","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s41419-020-2473-5","volume":"11","author":"H-X Chen","year":"2020","unstructured":"Chen H-X, Liang F-C, Gu P et al (2020) Exosomes derived from mesenchymal stem cells repair a Parkinson\u2019s disease model by inducing autophagy. Cell Death Dis 11:288. https:\/\/doi.org\/10.1038\/s41419-020-2473-5","journal-title":"Cell Death Dis"},{"key":"1575_CR10","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12774","volume":"71","author":"C Chen","year":"2021","unstructured":"Chen C, Yang C, Wang J et al (2021a) Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer\u2019s disease. J Pineal Res 71:e12774. https:\/\/doi.org\/10.1111\/jpi.12774","journal-title":"J Pineal Res"},{"key":"1575_CR11","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.379","volume":"11","author":"S-Z Chen","year":"2021","unstructured":"Chen S-Z, Ling Y, Yu L-X et al (2021b) 4-phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR-\u03b1. Clin Transl Med 11:e379. https:\/\/doi.org\/10.1002\/ctm2.379","journal-title":"Clin Transl Med"},{"key":"1575_CR12","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","volume":"8","author":"X Chen","year":"2023","unstructured":"Chen X, Shi C, He M et al (2023) Endoplasmic reticulum stress: molecular mechanism and therapeutic targets. Signal Transduct Target Ther 8:352. https:\/\/doi.org\/10.1038\/s41392-023-01570-w","journal-title":"Signal Transduct Target Ther"},{"key":"1575_CR13","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1053\/j.gastro.2022.04.013","volume":"163","author":"J Choi","year":"2022","unstructured":"Choi J, Oh TG, Jung H-W et al (2022) Estrogen-related receptor \u03b3 maintains pancreatic acinar cell function and identity by regulating cellular metabolism. Gastroenterology 163:239\u2013256. https:\/\/doi.org\/10.1053\/j.gastro.2022.04.013","journal-title":"Gastroenterology"},{"key":"1575_CR14","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.1016\/j.scib.2024.10.027","volume":"69","author":"W Cui","year":"2024","unstructured":"Cui W, Guo Z, Chen X et al (2024) Targeting modulation of intestinal flora through oral route by an antimicrobial nucleic acid-loaded exosome-like nanovesicles to improve Parkinson\u2019s disease. Sci Bull 69:3925\u20133935. https:\/\/doi.org\/10.1016\/j.scib.2024.10.027","journal-title":"Sci Bull"},{"key":"1575_CR15","doi-asserted-by":"publisher","first-page":"15816","DOI":"10.3390\/ijms242115816","volume":"24","author":"P Delmotte","year":"2023","unstructured":"Delmotte P, Yap JQ, Dasgupta D, Sieck GC (2023) Chemical chaperone 4-PBA mitigates tumor necrosis factor alpha-induced endoplasmic reticulum stress in human airway smooth muscle. Int J Mol Sci 24:15816. https:\/\/doi.org\/10.3390\/ijms242115816","journal-title":"Int J Mol Sci"},{"key":"1575_CR16","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41392-023-01353-3","volume":"8","author":"X Dong-Chen","year":"2023","unstructured":"Dong-Chen X, Yong C, Yang X et al (2023) Signaling pathways in Parkinson\u2019s disease: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther 8:73. https:\/\/doi.org\/10.1038\/s41392-023-01353-3","journal-title":"Signal Transduct Target Ther"},{"key":"1575_CR17","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1080\/15384101.2021.1974791","volume":"20","author":"J Du","year":"2021","unstructured":"Du J, Song D, Cao T et al (2021) Saikosaponin-A induces apoptosis of cervical cancer through mitochondria- and endoplasmic reticulum stress-dependent pathway in vitro and in vivo: involvement of PI3K\/AKT signaling pathway. Cell Cycle 20:2221\u20132232. https:\/\/doi.org\/10.1080\/15384101.2021.1974791","journal-title":"Cell Cycle"},{"key":"1575_CR18","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1038\/emboj.2012.170","volume":"31","author":"N Exner","year":"2012","unstructured":"Exner N, Lutz AK, Haass C, Winklhofer KF (2012) Mitochondrial dysfunction in Parkinson\u2019s disease: molecular mechanisms and pathophysiological consequences. EMBO J 31:3038\u20133062. https:\/\/doi.org\/10.1038\/emboj.2012.170","journal-title":"EMBO J"},{"key":"1575_CR19","doi-asserted-by":"publisher","first-page":"6127","DOI":"10.3390\/ijms21176127","volume":"21","author":"R Ghemrawi","year":"2020","unstructured":"Ghemrawi R, Khair M (2020) Endoplasmic reticulum stress and unfolded protein response in neurodegenerative diseases. Int J Mol Sci 21:6127. https:\/\/doi.org\/10.3390\/ijms21176127","journal-title":"Int J Mol Sci"},{"key":"1575_CR20","doi-asserted-by":"publisher","first-page":"1255555","DOI":"10.1126\/science.1255555","volume":"349","author":"M Goedert","year":"2015","unstructured":"Goedert M (2015) Neurodegeneration Alzheimer\u2019s and Parkinson\u2019s diseases: the prion concept in relation to assembled A\u03b2, tau, and \u03b1-synuclein. Science 349:1255555. https:\/\/doi.org\/10.1126\/science.1255555","journal-title":"Science"},{"key":"1575_CR21","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3389\/fneur.2020.00587","volume":"11","author":"D Grossmann","year":"2020","unstructured":"Grossmann D, Berenguer-Escuder C, Chemla A et al (2020) The emerging role of RHOT1\/Miro1 in the pathogenesis of Parkinson\u2019s disease. Front Neurol 11:587. https:\/\/doi.org\/10.3389\/fneur.2020.00587","journal-title":"Front Neurol"},{"key":"1575_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102010","volume":"44","author":"X Han","year":"2021","unstructured":"Han X, Xu T, Fang Q et al (2021) Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy. Redox Biol 44:102010. https:\/\/doi.org\/10.1016\/j.redox.2021.102010","journal-title":"Redox Biol"},{"key":"1575_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102299","volume":"97","author":"S Hassani","year":"2024","unstructured":"Hassani S, Esmaeili A (2024) The neuroprotective effects of ferulic acid in toxin-induced models of Parkinson\u2019s disease: a review. Ageing Res Rev 97:102299. https:\/\/doi.org\/10.1016\/j.arr.2024.102299","journal-title":"Ageing Res Rev"},{"key":"1575_CR24","doi-asserted-by":"publisher","first-page":"133","DOI":"10.7150\/thno.37362","volume":"10","author":"Y He","year":"2020","unstructured":"He Y, Li W, Zheng Z et al (2020) Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death. Theranostics 10:133","journal-title":"Theranostics"},{"key":"1575_CR25","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1111\/1440-1681.13541","volume":"48","author":"J He","year":"2021","unstructured":"He J, Gong M, Wang Z et al (2021) Cardiac abnormalities after induction of endoplasmic reticulum stress are associated with mitochondrial dysfunction and connexin43 expression. Clin Exp Pharmacol Physiol 48:1371\u20131381. https:\/\/doi.org\/10.1111\/1440-1681.13541","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"1575_CR26","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s13024-023-00676-7","volume":"18","author":"MT Henrich","year":"2023","unstructured":"Henrich MT, Oertel WH, Surmeier DJ, Geibl FF (2023) Mitochondrial dysfunction in Parkinson\u2019s disease\u2014a key disease hallmark with therapeutic potential. Mol Neurodegener 18:83. https:\/\/doi.org\/10.1186\/s13024-023-00676-7","journal-title":"Mol Neurodegener"},{"key":"1575_CR27","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1038\/s41598-023-28395-5","volume":"13","author":"L Hong","year":"2023","unstructured":"Hong L, Xu Y, Wang D et al (2023) Sulforaphane ameliorates bisphenol A-induced hepatic lipid accumulation by inhibiting endoplasmic reticulum stress. Sci Rep 13:1147. https:\/\/doi.org\/10.1038\/s41598-023-28395-5","journal-title":"Sci Rep"},{"key":"1575_CR28","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/901780","volume":"2015","author":"W Huang","year":"2015","unstructured":"Huang W, Cash N, Wen L et al (2015) Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis. Mediators Inflamm 2015:901780. https:\/\/doi.org\/10.1155\/2015\/901780","journal-title":"Mediators Inflamm"},{"key":"1575_CR29","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1136\/jnnp-2019-322338","volume":"91","author":"J Jankovic","year":"2020","unstructured":"Jankovic J, Tan EK (2020) Parkinson\u2019s disease: etiopathogenesis and treatment. J Neurol Neurosurg Psychiatry 91:795\u2013808. https:\/\/doi.org\/10.1136\/jnnp-2019-322338","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1575_CR30","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1750-1326-5-56","volume":"5","author":"P Jiang","year":"2010","unstructured":"Jiang P, Gan M, Ebrahim AS et al (2010) ER stress response plays an important role in aggregation of \u03b1-synuclein. Mol Neurodegener 5:56. https:\/\/doi.org\/10.1186\/1750-1326-5-56","journal-title":"Mol Neurodegener"},{"key":"1575_CR31","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.biocel.2015.01.015","volume":"61","author":"PS Kolb","year":"2015","unstructured":"Kolb PS, Ayaub EA, Zhou W et al (2015) The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis. Int J Biochem Cell Biol 61:45\u201352. https:\/\/doi.org\/10.1016\/j.biocel.2015.01.015","journal-title":"Int J Biochem Cell Biol"},{"key":"1575_CR32","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1038\/s41556-021-00798-4","volume":"23","author":"T K\u00f6nig","year":"2021","unstructured":"K\u00f6nig T, Nolte H, Aaltonen MJ et al (2021) MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control. Nat Cell Biol 23:1271\u20131286. https:\/\/doi.org\/10.1038\/s41556-021-00798-4","journal-title":"Nat Cell Biol"},{"key":"1575_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2024.08.007","author":"A Larra\u00f1aga-SanMiguel","year":"2024","unstructured":"Larra\u00f1aga-SanMiguel A, Bengoa-Vergniory N, Flores-Romero H (2024) Crosstalk between mitochondria\u2013ER contact sites and the apoptotic machinery as a novel health meter. Trends Cell Biol. https:\/\/doi.org\/10.1016\/j.tcb.2024.08.007","journal-title":"Trends Cell Biol"},{"key":"1575_CR34","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/j.1600-079x.2004.00116.x","volume":"36","author":"SP Li","year":"2004","unstructured":"Li SP, Deng YQ, Wang XC et al (2004) Melatonin protects SH-SY5Y neuroblastoma cells from calyculin A-induced neurofilament impairment and neurotoxicity. J Pineal Res 36:186\u2013191. https:\/\/doi.org\/10.1111\/j.1600-079x.2004.00116.x","journal-title":"J Pineal Res"},{"key":"1575_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105605","volume":"163","author":"J Li","year":"2022","unstructured":"Li J, Chen L, Qin Q et al (2022) Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson\u2019s disease. Neurobiol Dis 163:105605. https:\/\/doi.org\/10.1016\/j.nbd.2021.105605","journal-title":"Neurobiol Dis"},{"key":"1575_CR36","doi-asserted-by":"publisher","first-page":"6143","DOI":"10.1038\/s41467-024-50502-x","volume":"15","author":"M Liiv","year":"2024","unstructured":"Liiv M, Vaarmann A, Safiulina D et al (2024) ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome. Nat Commun 15:6143. https:\/\/doi.org\/10.1038\/s41467-024-50502-x","journal-title":"Nat Commun"},{"key":"1575_CR37","doi-asserted-by":"publisher","first-page":"7762","DOI":"10.1007\/s12035-016-0249-9","volume":"54","author":"Z Liu","year":"2017","unstructured":"Liu Z, Huang Y, Cao B-B et al (2017) Th17 cells induce dopaminergic neuronal death via LFA-1\/ICAM-1 interaction in a mouse model of Parkinson\u2019s disease. Mol Neurobiol 54:7762\u20137776. https:\/\/doi.org\/10.1007\/s12035-016-0249-9","journal-title":"Mol Neurobiol"},{"key":"1575_CR38","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.bbi.2021.08.220","volume":"98","author":"Z Liu","year":"2021","unstructured":"Liu Z, Zhai X-R, Du Z-S et al (2021) Dopamine receptor D2 on CD4+ T cells is protective against neuroinflammation and neurodegeneration in a mouse model of Parkinson\u2019s disease. Brain Behav Immun 98:110\u2013121. https:\/\/doi.org\/10.1016\/j.bbi.2021.08.220","journal-title":"Brain Behav Immun"},{"key":"1575_CR39","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.cbi.2015.09.025","volume":"242","author":"T Luo","year":"2015","unstructured":"Luo T, Chen B, Wang X (2015) 4-PBA prevents pressure overload-induced myocardial hypertrophy and interstitial fibrosis by attenuating endoplasmic reticulum stress. Chem-Biol Interact 242:99\u2013106. https:\/\/doi.org\/10.1016\/j.cbi.2015.09.025","journal-title":"Chem-Biol Interact"},{"key":"1575_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114710","volume":"254","author":"L Ma","year":"2023","unstructured":"Ma L, Hai S, Wang C et al (2023) Zearalenone induces mitochondria-associated endoplasmic reticulum membranes dysfunction in piglet Sertoli cells based on endoplasmic reticulum stress. Ecotoxicol Environ Saf 254:114710. https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114710","journal-title":"Ecotoxicol Environ Saf"},{"key":"1575_CR41","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.tibs.2020.11.007","volume":"46","author":"AB Malpartida","year":"2021","unstructured":"Malpartida AB, Williamson M, Narendra DP et al (2021) Mitochondrial dysfunction and mitophagy in Parkinson\u2019s disease: from mechanism to therapy. Trends Biochem Sci 46:329\u2013343. https:\/\/doi.org\/10.1016\/j.tibs.2020.11.007","journal-title":"Trends Biochem Sci"},{"key":"1575_CR42","doi-asserted-by":"publisher","first-page":"6835","DOI":"10.1016\/j.cell.2024.09.037","volume":"187","author":"K Matsuo","year":"2024","unstructured":"Matsuo K, Asamitsu S, Maeda K et al (2024) RNA G-quadruplexes form scaffolds that promote neuropathological \u03b1-synuclein aggregation. Cell 187:6835-6848.e20. https:\/\/doi.org\/10.1016\/j.cell.2024.09.037","journal-title":"Cell"},{"key":"1575_CR43","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.molmed.2012.12.005","volume":"19","author":"G Mercado","year":"2013","unstructured":"Mercado G, Vald\u00e9s P, Hetz C (2013) An ercentric view of Parkinson\u2019s disease. Trends Mol Med 19:165\u2013175. https:\/\/doi.org\/10.1016\/j.molmed.2012.12.005","journal-title":"Trends Mol Med"},{"key":"1575_CR44","doi-asserted-by":"publisher","first-page":"15186","DOI":"10.3390\/ijms232315186","volume":"23","author":"A Merighi","year":"2022","unstructured":"Merighi A, Lossi L (2022) Endoplasmic reticulum stress signaling and neuronal cell death. Int J Mol Sci 23:15186. https:\/\/doi.org\/10.3390\/ijms232315186","journal-title":"Int J Mol Sci"},{"key":"1575_CR45","doi-asserted-by":"publisher","first-page":"11444","DOI":"10.3390\/ijms222111444","volume":"22","author":"LE Millichap","year":"2021","unstructured":"Millichap LE, Damiani E, Tiano L, Hargreaves IP (2021) Targetable pathways for alleviating mitochondrial dysfunction in neurodegeneration of metabolic and non-metabolic diseases. Int J Mol Sci 22:11444. https:\/\/doi.org\/10.3390\/ijms222111444","journal-title":"Int J Mol Sci"},{"key":"1575_CR46","doi-asserted-by":"publisher","first-page":"4399","DOI":"10.1038\/s41467-019-12382-4","volume":"10","author":"S Modi","year":"2019","unstructured":"Modi S, L\u00f3pez-Dom\u00e9nech G, Halff EF et al (2019) Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery. Nat Commun 10:4399. https:\/\/doi.org\/10.1038\/s41467-019-12382-4","journal-title":"Nat Commun"},{"key":"1575_CR47","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011338","volume":"4","author":"D Narendra","year":"2012","unstructured":"Narendra D, Walker JE, Youle R (2012) Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism. Cold Spring Harb Perspect Biol 4:a011338. https:\/\/doi.org\/10.1101\/cshperspect.a011338","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"1575_CR48","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.tins.2018.11.001","volume":"42","author":"M Nguyen","year":"2019","unstructured":"Nguyen M, Wong YC, Ysselstein D et al (2019) Synaptic, mitochondrial, and lysosomal dysfunction in Parkinson\u2019s disease. Trends Neurosci 42:140\u2013149. https:\/\/doi.org\/10.1016\/j.tins.2018.11.001","journal-title":"Trends Neurosci"},{"key":"1575_CR49","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1146\/annurev-pathol-012513-104649","volume":"10","author":"SA Oakes","year":"2015","unstructured":"Oakes SA, Papa FR (2015) The role of endoplasmic reticulum stress in human pathology. Annu Rev Pathol 10:173\u2013194. https:\/\/doi.org\/10.1146\/annurev-pathol-012513-104649","journal-title":"Annu Rev Pathol"},{"key":"1575_CR50","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/s43587-024-00633-z","volume":"4","author":"J Park","year":"2024","unstructured":"Park J, Hu R, Qian Y et al (2024) Estrogen counteracts age-related decline in beige adipogenesis through the NAMPT-regulated ER stress response. Nat Aging 4:839\u2013853. https:\/\/doi.org\/10.1038\/s43587-024-00633-z","journal-title":"Nat Aging"},{"key":"1575_CR51","doi-asserted-by":"publisher","first-page":"e99384","DOI":"10.15252\/embj.201899384","volume":"38","author":"D Safiulina","year":"2019","unstructured":"Safiulina D, Kuum M, Choubey V et al (2019) Miro proteins prime mitochondria for Parkin translocation and mitophagy. EMBO J 38:e99384. https:\/\/doi.org\/10.15252\/embj.201899384","journal-title":"EMBO J"},{"key":"1575_CR52","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s13046-023-02677-2","volume":"42","author":"A Saha","year":"2023","unstructured":"Saha A, Zhao S, Kindall A et al (2023) Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition. J Exp Clin Cancer Res 42:119. https:\/\/doi.org\/10.1186\/s13046-023-02677-2","journal-title":"J Exp Clin Cancer Res"},{"key":"1575_CR53","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13024-017-0183-y","volume":"12","author":"NT Sprenkle","year":"2017","unstructured":"Sprenkle NT, Sims SG, S\u00e1nchez CL, Meares GP (2017) Endoplasmic reticulum stress and inflammation in the central nervous system. Mol Neurodegener 12:42. https:\/\/doi.org\/10.1186\/s13024-017-0183-y","journal-title":"Mol Neurodegener"},{"key":"1575_CR54","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/S1474-4422(07)70246-6","volume":"6","author":"DJ Surmeier","year":"2007","unstructured":"Surmeier DJ (2007) Calcium, ageing, and neuronal vulnerability in Parkinson\u2019s disease. Lancet Neurol 6:933\u2013938. https:\/\/doi.org\/10.1016\/S1474-4422(07)70246-6","journal-title":"Lancet Neurol"},{"key":"1575_CR55","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2022.58719.13043","author":"M Tatar","year":"2022","unstructured":"Tatar M, Eren \u00dc (2022) Protective and therapeutic role of melatonin against tunicamycin-induced ER stress in testicular tissue of rats. Iran J Basic Med Sci. https:\/\/doi.org\/10.22038\/ijbms.2022.58719.13043","journal-title":"Iran J Basic Med Sci"},{"key":"1575_CR56","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.molmed.2010.11.002","volume":"17","author":"C Vives-Bauza","year":"2011","unstructured":"Vives-Bauza C, Przedborski S (2011) Mitophagy: the latest problem for Parkinson\u2019s disease. Trends Mol Med 17:158\u2013165. https:\/\/doi.org\/10.1016\/j.molmed.2010.11.002","journal-title":"Trends Mol Med"},{"key":"1575_CR57","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.cell.2011.10.018","volume":"147","author":"X Wang","year":"2011","unstructured":"Wang X, Winter D, Ashrafi G et al (2011) PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 147:893\u2013906. https:\/\/doi.org\/10.1016\/j.cell.2011.10.018","journal-title":"Cell"},{"key":"1575_CR58","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1080\/15548627.2023.2287930","volume":"20","author":"Y Wang","year":"2024","unstructured":"Wang Y, Ping Z, Gao H et al (2024) LYC inhibits the AKT signaling pathway to activate autophagy and ameliorate TGFB-induced renal fibrosis. Autophagy 20:1114\u20131133. https:\/\/doi.org\/10.1080\/15548627.2023.2287930","journal-title":"Autophagy"},{"key":"1575_CR60","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s11325-018-1739-y","volume":"23","author":"L Xin","year":"2019","unstructured":"Xin L, Fan W, Tingting D et al (2019) 4-phenylbutyric acid attenuates endoplasmic reticulum stress-mediated apoptosis and protects the hepatocytes from intermittent hypoxia-induced injury. Sleep Breath 23:711\u2013717. https:\/\/doi.org\/10.1007\/s11325-018-1739-y","journal-title":"Sleep Breath"},{"key":"1575_CR61","doi-asserted-by":"publisher","first-page":"6253","DOI":"10.3390\/molecules27196253","volume":"27","author":"H-H Xu","year":"2022","unstructured":"Xu H-H, Yang L, Tang M-X et al (2022) From cis-lobeline to trans-lobeline: study on the pharmacodynamics and isomerization factors. Molecules 27:6253. https:\/\/doi.org\/10.3390\/molecules27196253","journal-title":"Molecules"},{"key":"1575_CR62","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1080\/15548627.2020.1725377","volume":"17","author":"R-Q Yao","year":"2021","unstructured":"Yao R-Q, Ren C, Xia Z-F, Yao Y-M (2021) Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles. Autophagy 17:385\u2013401. https:\/\/doi.org\/10.1080\/15548627.2020.1725377","journal-title":"Autophagy"},{"key":"1575_CR63","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3390\/ijms17030327","volume":"17","author":"H Zeeshan","year":"2016","unstructured":"Zeeshan H, Lee G, Kim H-R, Chae H-J (2016) Endoplasmic reticulum stress and associated ROS. Int J Mol Sci 17:327. https:\/\/doi.org\/10.3390\/ijms17030327","journal-title":"Int J Mol Sci"},{"key":"1575_CR64","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.toxlet.2017.02.023","volume":"271","author":"M Zeng","year":"2017","unstructured":"Zeng M, Sang W, Chen S et al (2017) 4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models. Toxicol Lett 271:26\u201337. https:\/\/doi.org\/10.1016\/j.toxlet.2017.02.023","journal-title":"Toxicol Lett"},{"key":"1575_CR65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179042","volume":"12","author":"C Zhang","year":"2017","unstructured":"Zhang C, Tang Y, Li Y et al (2017) Unfolded protein response plays a critical role in heart damage after myocardial ischemia\/reperfusion in rats. PLoS ONE 12:e0179042. https:\/\/doi.org\/10.1371\/journal.pone.0179042","journal-title":"PLoS ONE"},{"key":"1575_CR66","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/s41422-018-0065-z","volume":"28","author":"P Zheng","year":"2018","unstructured":"Zheng P, Chen Q, Tian X et al (2018) DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling. Cell Res 28:833\u2013854. https:\/\/doi.org\/10.1038\/s41422-018-0065-z","journal-title":"Cell Res"},{"key":"1575_CR67","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/s41419-020-2424-1","volume":"11","author":"J Zheng","year":"2020","unstructured":"Zheng J, Chen L, Lu T et al (2020) MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia\/reperfusion injury through AMPK\u03b1 activation. Cell Death Dis 11:256. https:\/\/doi.org\/10.1038\/s41419-020-2424-1","journal-title":"Cell Death Dis"},{"key":"1575_CR68","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s13046-023-02702-4","volume":"42","author":"F Zhou","year":"2023","unstructured":"Zhou F, Gao H, Shang L et al (2023) Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer. J Exp Clin Cancer Res 42:150. https:\/\/doi.org\/10.1186\/s13046-023-02702-4","journal-title":"J Exp Clin Cancer Res"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-025-01575-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10571-025-01575-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-025-01575-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T10:23:27Z","timestamp":1765535007000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10571-025-01575-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":67,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1575"],"URL":"https:\/\/doi.org\/10.1007\/s10571-025-01575-9","relation":{},"ISSN":["1573-6830"],"issn-type":[{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,29]]},"assertion":[{"value":"4 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"All animal experimental protocols were approved by the Animal Experimentation Ethics Committee of Tangdu Hospital, the Fourth Military Medical University (Grant No. 202203-074) and conducted according to the Animal Care and Use Committee Guidelines of the Fourth Military Medical University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional Review Board Statement"}}],"article-number":"53"}}