{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T10:26:42Z","timestamp":1765535202184,"version":"3.48.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Public welfare research project of Jiaxing science and technology bureau","award":["2022AD10030"],"award-info":[{"award-number":["2022AD10030"]}]},{"name":"Scientific research fund of Zhejiang provincial education department","award":["Y202147818"],"award-info":[{"award-number":["Y202147818"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"DOI":"10.1007\/s10571-025-01629-y","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:51:05Z","timestamp":1763466665000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Copper and Iron Metabolism Related Biomarkers in Alzheimer\u2019s Disease"],"prefix":"10.1007","volume":"45","author":[{"given":"Dandan","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shasha","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"1629_CR1","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2012.10.558","volume":"62","author":"S Ayton","year":"2013","unstructured":"Ayton S, Lei P, Bush AI (2013) Metallostasis in alzheimer\u2019s disease. Free Radic Biol Med 62:76\u201389. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2012.10.558","journal-title":"Free Radic Biol Med"},{"key":"1629_CR2","doi-asserted-by":"publisher","first-page":"9565545","DOI":"10.1155\/2022\/9565545","volume":"2022","author":"F Chen","year":"2022","unstructured":"Chen F, Bai J, Zhong S, Zhang R, Zhang X, Xu Y, Zhao M, Zhao C et al (2022) Molecular signatures of mitochondrial complexes involved in alzheimer\u2019s disease via oxidative phosphorylation and retrograde endocannabinoid signaling pathways. Oxid Med Cell Longev 2022:9565545. https:\/\/doi.org\/10.1155\/2022\/9565545","journal-title":"Oxid Med Cell Longev"},{"key":"1629_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.nut.2010.07.021","volume":"27","author":"S Cunnane","year":"2011","unstructured":"Cunnane S, Nugent S, Roy M, Courchesne-Loyer A, Croteau E, Tremblay S, Castellano A, Pifferi F et al (2011) Brain fuel metabolism, aging, and alzheimer\u2019s disease. Nutrition 27:3\u201320. https:\/\/doi.org\/10.1016\/j.nut.2010.07.021","journal-title":"Nutrition"},{"key":"1629_CR4","doi-asserted-by":"publisher","unstructured":"Curnock R, Cullen PJ (2020) Mammalian copper homeostasis requires retromer-dependent recycling of the high-affinity copper transporter 1. J Cell Sci 133. https:\/\/doi.org\/10.1242\/jcs.249201","DOI":"10.1242\/jcs.249201"},{"key":"1629_CR5","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/nrn3012","volume":"12","author":"G Di Paolo","year":"2011","unstructured":"Di Paolo G, Kim TW (2011) Linking lipids to alzheimer\u2019s disease: cholesterol and beyond. Nat Rev Neurosci 12:284\u2013296. https:\/\/doi.org\/10.1038\/nrn3012","journal-title":"Nat Rev Neurosci"},{"key":"1629_CR6","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1128\/mcb.06051-11","volume":"32","author":"F Diaz","year":"2012","unstructured":"Diaz F, Enr\u00edquez JA, Moraes CT (2012) Cells lacking Rieske iron-sulfur protein have a reactive oxygen species-associated decrease in respiratory complexes I and IV. Mol Cell Biol 32:415\u2013429. https:\/\/doi.org\/10.1128\/mcb.06051-11","journal-title":"Mol Cell Biol"},{"key":"1629_CR7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3389\/fnagi.2013.00009","volume":"5","author":"R Dringen","year":"2013","unstructured":"Dringen R, Scheiber IF, Mercer JF (2013) Copper metabolism of astrocytes. Front Aging Neurosci 5:9. https:\/\/doi.org\/10.3389\/fnagi.2013.00009","journal-title":"Front Aging Neurosci"},{"key":"1629_CR8","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.3233\/jad-230565","volume":"95","author":"Y Du","year":"2023","unstructured":"Du Y, Chen X, Zhang B, Jin X, Wan Z, Zhan M, Yan J, Zhang P et al (2023) Identification of copper metabolism related Biomarkers, polygenic prediction Model, and potential therapeutic agents in alzheimer\u2019s disease. J Alzheimers Dis 95:1481\u20131496. https:\/\/doi.org\/10.3233\/jad-230565","journal-title":"J Alzheimers Dis"},{"key":"1629_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239259","author":"G Gromadzka","year":"2020","unstructured":"Gromadzka G, Tarnacka B, Flaga A, Adamczyk A (2020) Copper dyshomeostasis in neurodegenerative Diseases-Therapeutic implications. Int J Mol Sci 21. https:\/\/doi.org\/10.3390\/ijms21239259","journal-title":"Int J Mol Sci 21"},{"key":"1629_CR10","doi-asserted-by":"publisher","first-page":"949083","DOI":"10.3389\/fnagi.2022.949083","volume":"14","author":"X Gu","year":"2022","unstructured":"Gu X, Lai D, Liu S, Chen K, Zhang P, Chen B, Huang G, Cheng X et al (2022) Hub Genes, diagnostic Model, and predicted drugs related to iron metabolism in alzheimer\u2019s disease. Front Aging Neurosci 14:949083. https:\/\/doi.org\/10.3389\/fnagi.2022.949083","journal-title":"Front Aging Neurosci"},{"key":"1629_CR11","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2174\/1567205052772786","volume":"2","author":"X Han","year":"2005","unstructured":"Han X (2005) Lipid alterations in the earliest clinically recognizable stage of alzheimer\u2019s disease: implication of the role of lipids in the pathogenesis of alzheimer\u2019s disease. Curr Alzheimer Res 2:65\u201377. https:\/\/doi.org\/10.2174\/1567205052772786","journal-title":"Curr Alzheimer Res"},{"key":"1629_CR12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1750-1326-6-53","volume":"6","author":"SM Kilbride","year":"2011","unstructured":"Kilbride SM, Gluchowska SA, Telford JE, O\u2019Sullivan C, Davey GP (2011) High-level Inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal. Mol Neurodegener 6:53. https:\/\/doi.org\/10.1186\/1750-1326-6-53","journal-title":"Mol Neurodegener"},{"key":"1629_CR14","first-page":"33","volume":"25","author":"S K\u00f5ks","year":"2000","unstructured":"K\u00f5ks S, M\u00e4nnist\u00f6 PT, Bourin M, Shlik J, Vasar V, Vasar E (2000) Cholecystokinin-induced anxiety in rats: relevance of pre-experimental stress and seasonal variations. J Psychiatry Neurosci 25:33\u201342","journal-title":"J Psychiatry Neurosci"},{"key":"1629_CR13","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1046\/j.1601-183x.2003.00047.x","volume":"3","author":"S K\u00f5ks","year":"2004","unstructured":"K\u00f5ks S, Luuk H, Nelovkov A, Areda T, Vasar E (2004) A screen for genes induced in the amygdaloid area during Cat odor exposure. Genes Brain Behav 3:80\u201389. https:\/\/doi.org\/10.1046\/j.1601-183x.2003.00047.x","journal-title":"Genes Brain Behav"},{"key":"1629_CR15","doi-asserted-by":"publisher","first-page":"137194","DOI":"10.1016\/j.neulet.2023.137194","volume":"803","author":"H Li","year":"2023","unstructured":"Li H, Zhang D, Wang X, Wang S, Xiao M (2023) Protective effect of glutamic-oxaloacetic transaminase on hippocampal neurons in alzheimer\u2019s disease using model mice. Neurosci Lett 803:137194. https:\/\/doi.org\/10.1016\/j.neulet.2023.137194","journal-title":"Neurosci Lett"},{"key":"1629_CR16","doi-asserted-by":"publisher","first-page":"117814","DOI":"10.1016\/j.biopha.2025.117814","volume":"183","author":"Y Li","year":"2025","unstructured":"Li Y, Han Y, Shu Q, Kan YK, Wang Z (2025) Cuproptosis and copper as potential mechanisms and intervention targets in alzheimer\u2019s disease. Biomed Pharmacother 183:117814. https:\/\/doi.org\/10.1016\/j.biopha.2025.117814","journal-title":"Biomed Pharmacother"},{"key":"1629_CR18","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1152\/physiolgenomics.00208.2006","volume":"28","author":"WS Liang","year":"2007","unstructured":"Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Walker DG, Caselli RJ, Kukull WA et al (2007) Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. Physiol Genomics 28:311\u2013322. https:\/\/doi.org\/10.1152\/physiolgenomics.00208.2006","journal-title":"Physiol Genomics"},{"key":"1629_CR17","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1152\/physiolgenomics.00242.2007","volume":"33","author":"WS Liang","year":"2008","unstructured":"Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA et al (2008a) Altered neuronal gene expression in brain regions differentially affected by alzheimer\u2019s disease: a reference data set. Physiol Genomics 33:240\u2013256. https:\/\/doi.org\/10.1152\/physiolgenomics.00242.2007","journal-title":"Physiol Genomics"},{"key":"1629_CR19","doi-asserted-by":"publisher","first-page":"4441","DOI":"10.1073\/pnas.0709259105","volume":"105","author":"WS Liang","year":"2008","unstructured":"Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Grover A, Niedzielko TL, Schneider LE et al (2008b) Alzheimer\u2019s disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. Proc Natl Acad Sci U S A 105:4441\u20134446. https:\/\/doi.org\/10.1073\/pnas.0709259105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1629_CR20","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/b978-0-12-819975-6.00017-0","volume":"179","author":"ASP Lim","year":"2021","unstructured":"Lim ASP (2021) Diurnal and seasonal molecular rhythms in the human brain and their relation to alzheimer disease. Handb Clin Neurol 179:271\u2013284. https:\/\/doi.org\/10.1016\/b978-0-12-819975-6.00017-0","journal-title":"Handb Clin Neurol"},{"key":"1629_CR21","doi-asserted-by":"publisher","first-page":"37245","DOI":"10.1074\/jbc.M112.366195","volume":"287","author":"JT Newington","year":"2012","unstructured":"Newington JT, Rappon T, Albers S, Wong DY, Rylett RJ, Cumming RC (2012) Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid \u03b2 and other toxins by decreasing mitochondrial respiration and reactive oxygen species production. J Biol Chem 287:37245\u201337258. https:\/\/doi.org\/10.1074\/jbc.M112.366195","journal-title":"J Biol Chem"},{"key":"1629_CR22","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1038\/s41386-021-01002-9","volume":"46","author":"AK N\u00f8hr","year":"2021","unstructured":"N\u00f8hr AK, Lindow M, Forsingdal A, Demharter S, Nielsen T, Buller R, Moltke I, Vitezic M et al (2021) A large-scale genome-wide gene expression analysis in peripheral blood identifies very few differentially expressed genes related to antidepressant treatment and response in patients with major depressive disorder. Neuropsychopharmacology 46:1324\u20131332. https:\/\/doi.org\/10.1038\/s41386-021-01002-9","journal-title":"Neuropsychopharmacology"},{"key":"1629_CR23","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1016\/j.cell.2021.03.056","volume":"184","author":"M Ota","year":"2021","unstructured":"Ota M, Nagafuchi Y, Hatano H, Ishigaki K, Terao C, Takeshima Y, Yanaoka H, Kobayashi S et al (2021) Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases. Cell 184:3006\u20133021. https:\/\/doi.org\/10.1016\/j.cell.2021.03.056","journal-title":"Cell"},{"key":"1629_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212442","author":"Y Peng","year":"2021","unstructured":"Peng Y, Chang X, Lang M (2021) Iron homeostasis disorder and alzheimer\u2019s disease. Int J Mol Sci 22. https:\/\/doi.org\/10.3390\/ijms222212442","journal-title":"Int J Mol Sci 22"},{"key":"1629_CR24","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.freeradbiomed.2024.09.034","volume":"224","author":"W Peng","year":"2024","unstructured":"Peng W, Chung KB, Lawrence BP, O\u2019Banion MK, Dirksen RT, Wojtovich AP, Onukwufor JO (2024) DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in C. elegans amyloid \u03b2 proteotoxicity. Free Radic Biol Med 224:785\u2013796. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2024.09.034","journal-title":"Free Radic Biol Med"},{"key":"1629_CR26","doi-asserted-by":"publisher","first-page":"691","DOI":"10.3233\/jad-181113","volume":"70","author":"IS Piras","year":"2019","unstructured":"Piras IS, Krate J, Delvaux E, Nolz J, Mastroeni DF, Persico AM, Jepsen WM, Beach TG et al (2019) Transcriptome changes in the alzheimer\u2019s disease middle Temporal gyrus: importance of RNA metabolism and Mitochondria-Associated membrane genes. J Alzheimers Dis 70:691\u2013713. https:\/\/doi.org\/10.3233\/jad-181113","journal-title":"J Alzheimers Dis"},{"key":"1629_CR27","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1080\/13880209.2022.2098344","volume":"60","author":"YJ Qu","year":"2022","unstructured":"Qu YJ, Ding MR, Gu C, Zhang LM, Zhen RR, Chen JF, Hu B, An HM (2022) Acteoside and ursolic acid synergistically protects H(2)O(2)-induced neurotrosis by regulation of AKT\/mTOR signalling: from network Pharmacology to experimental validation. Pharm Biol 60:1751\u20131761. https:\/\/doi.org\/10.1080\/13880209.2022.2098344","journal-title":"Pharm Biol"},{"key":"1629_CR28","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.neuron.2018.05.023","volume":"99","author":"B Readhead","year":"2018","unstructured":"Readhead B, Haure-Mirande JV, Funk CC, Richards MA, Shannon P, Haroutunian V, Sano M, Liang WS et al (2018) Multiscale analysis of independent alzheimer\u2019s cohorts finds disruption of Molecular, Genetic, and clinical networks by human herpesvirus. Neuron 99:64\u201382. https:\/\/doi.org\/10.1016\/j.neuron.2018.05.023","journal-title":"Neuron"},{"key":"1629_CR29","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK (2015) Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43:e47. https:\/\/doi.org\/10.1093\/nar\/gkv007","journal-title":"Nucleic Acids Res"},{"key":"1629_CR30","doi-asserted-by":"publisher","DOI":"10.1093\/mtomcs\/mfac018","author":"SK Singh","year":"2022","unstructured":"Singh SK, Balendra V, Obaid AA, Esposto J, Tikhonova MA, Gautam NK, Poeggeler B (2022) Copper-mediated \u03b2-amyloid toxicity and its chelation therapy in alzheimer\u2019s disease. Metallomics 14. https:\/\/doi.org\/10.1093\/mtomcs\/mfac018","journal-title":"Metallomics 14"},{"key":"1629_CR31","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","volume":"49","author":"D Szklarczyk","year":"2021","unstructured":"Szklarczyk D, Gable AL, Nastou KC, Lyon D, Kirsch R, Pyysalo S, Doncheva NT, Legeay M et al (2021) The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets. Nucleic Acids Res 49:D605\u2013d. https:\/\/doi.org\/10.1093\/nar\/gkaa1074","journal-title":"Nucleic Acids Res"},{"key":"1629_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-981-13-9589-5_1","volume":"1173","author":"A Thirupathi","year":"2019","unstructured":"Thirupathi A, Chang YZ (2019) Brain iron metabolism and CNS diseases. Adv Exp Med Biol 1173:1\u201319. https:\/\/doi.org\/10.1007\/978-981-13-9589-5_1","journal-title":"Adv Exp Med Biol"},{"key":"1629_CR33","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/978-981-13-9589-5_5","volume":"1173","author":"T Wang","year":"2019","unstructured":"Wang T, Xu SF, Fan YG, Li LB, Guo C (2019) Iron pathophysiology in alzheimer\u2019s diseases. Adv Exp Med Biol 1173:67\u2013104. https:\/\/doi.org\/10.1007\/978-981-13-9589-5_5","journal-title":"Adv Exp Med Biol"},{"key":"1629_CR34","doi-asserted-by":"publisher","first-page":"3564","DOI":"10.1016\/j.cub.2022.07.010","volume":"32","author":"A Wiehler","year":"2022","unstructured":"Wiehler A, Branzoli F, Adanyeguh I, Mochel F, Pessiglione M (2022) A neuro-metabolic account of why daylong cognitive work alters the control of economic decisions. Curr Biol 32:3564\u20133575. https:\/\/doi.org\/10.1016\/j.cub.2022.07.010","journal-title":"Curr Biol"},{"key":"1629_CR35","doi-asserted-by":"publisher","first-page":"327","DOI":"10.62347\/obzs8887","volume":"14","author":"Z Xiao","year":"2024","unstructured":"Xiao Z, Li Y, Haider A, Pfister SK, Rong J, Chen J, Zhao C, Zhou X et al (2024) Radiosynthesis and evaluation of a novel (18)F-labeled tracer for PET imaging of glycogen synthase kinase 3. Am J Nucl Med Mol Imaging 14:327\u2013336. https:\/\/doi.org\/10.62347\/obzs8887","journal-title":"Am J Nucl Med Mol Imaging"},{"key":"1629_CR37","doi-asserted-by":"publisher","first-page":"13763","DOI":"10.1038\/s41598-017-12800-x","volume":"7","author":"W Xu","year":"2017","unstructured":"Xu W, Xu Q, Cheng H, Tan X (2017) The efficacy and Pharmacological mechanism of Zn(7)MT3 to protect against alzheimer\u2019s disease. Sci Rep 7:13763. https:\/\/doi.org\/10.1038\/s41598-017-12800-x","journal-title":"Sci Rep"},{"key":"1629_CR36","doi-asserted-by":"publisher","unstructured":"Xu W, Su X, Qin J, Jin Y, Zhang N, Huang S (2024) Identification of Autophagy-Related Biomarkers and Diagnostic Model in Alzheimer\u2019s Disease. Genes (Basel) 15. https:\/\/doi.org\/10.3390\/genes15081027","DOI":"10.3390\/genes15081027"},{"key":"1629_CR38","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY (2012) ClusterProfiler: an R package for comparing biological themes among gene clusters. Omics 16:284\u2013287. https:\/\/doi.org\/10.1089\/omi.2011.0118","journal-title":"Omics"},{"key":"1629_CR41","doi-asserted-by":"publisher","first-page":"6817","DOI":"10.1038\/s41598-023-34021-1","volume":"13","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Kiryu H (2023) Identification of oxidative stress-related genes differentially expressed in alzheimer\u2019s disease and construction of a hub gene-based diagnostic model. Sci Rep 13:6817. https:\/\/doi.org\/10.1038\/s41598-023-34021-1","journal-title":"Sci Rep"},{"key":"1629_CR39","doi-asserted-by":"publisher","first-page":"3724","DOI":"10.1093\/cercor\/bhw193","volume":"27","author":"D Zhang","year":"2017","unstructured":"Zhang D, Mably AJ, Walsh DM, Rowan MJ (2017) Peripheral interventions enhancing brain glutamate homeostasis relieve amyloid \u03b2- and TNF\u03b1- mediated synaptic plasticity disruption in the rat hippocampus. Cereb Cortex 27:3724\u20133735. https:\/\/doi.org\/10.1093\/cercor\/bhw193","journal-title":"Cereb Cortex"},{"key":"1629_CR40","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1007\/s12640-018-9961-8","volume":"35","author":"D Zhang","year":"2019","unstructured":"Zhang D, Xiao M, Wang L, Jia W (2019) Blood-Based glutamate scavengers reverse traumatic brain injury-Induced synaptic plasticity disruption by decreasing glutamate level in hippocampus interstitial Fluid, but not cerebral spinal Fluid, in vivo. Neurotox Res 35:360\u2013372. https:\/\/doi.org\/10.1007\/s12640-018-9961-8","journal-title":"Neurotox Res"},{"key":"1629_CR42","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1186\/s12967-023-04254-9","volume":"21","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Miao Y, Tan J, Chen F, Lei P, Zhang Q (2023a) Identification of mitochondrial related signature associated with immune microenvironment in alzheimer\u2019s disease. J Transl Med 21:458. https:\/\/doi.org\/10.1186\/s12967-023-04254-9","journal-title":"J Transl Med"},{"key":"1629_CR43","doi-asserted-by":"publisher","first-page":"17458","DOI":"10.1038\/s41598-023-44656-9","volume":"13","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Yang YS, Wang CM, Chen WC, Chen XL, Wu F, He HF (2023b) Copper metabolism-related genes in entorhinal cortex for alzheimer\u2019s disease. Sci Rep 13:17458. https:\/\/doi.org\/10.1038\/s41598-023-44656-9","journal-title":"Sci Rep"},{"key":"1629_CR44","doi-asserted-by":"publisher","first-page":"1280639","DOI":"10.3389\/fnmol.2023.1280639","volume":"16","author":"H Zhao","year":"2023","unstructured":"Zhao H, Wang J, Li Z, Wang S, Yu G, Wang L (2023) Identification ferroptosis-related hub genes and diagnostic model in alzheimer\u2019s disease. Front Mol Neurosci 16:1280639. https:\/\/doi.org\/10.3389\/fnmol.2023.1280639","journal-title":"Front Mol Neurosci"},{"key":"1629_CR45","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.2174\/1570159x22666231103085859","volume":"22","author":"G Zhong","year":"2024","unstructured":"Zhong G, Wang X, Li J, Xie Z, Wu Q, Chen J, Wang Y, Chen Z et al (2024) Insights into the role of copper in neurodegenerative diseases and the therapeutic potential of natural compounds. Curr Neuropharmacol 22:1650\u20131671. https:\/\/doi.org\/10.2174\/1570159x22666231103085859","journal-title":"Curr Neuropharmacol"},{"key":"1629_CR46","doi-asserted-by":"publisher","first-page":"13619","DOI":"10.1038\/s41598-024-64599-z","volume":"14","author":"X Zhuang","year":"2024","unstructured":"Zhuang X, Xia Y, Liu Y, Guo T, Xia Z, Wang Z, Zhang G (2024) SCG5 and MITF May be novel markers of copper metabolism immunorelevance in alzheimer\u2019s disease. Sci Rep 14:13619. https:\/\/doi.org\/10.1038\/s41598-024-64599-z","journal-title":"Sci Rep"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-025-01629-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10571-025-01629-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-025-01629-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T10:24:06Z","timestamp":1765535046000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10571-025-01629-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1629"],"URL":"https:\/\/doi.org\/10.1007\/s10571-025-01629-y","relation":{},"ISSN":["1573-6830"],"issn-type":[{"type":"electronic","value":"1573-6830"}],"subject":[],"published":{"date-parts":[[2025,11,18]]},"assertion":[{"value":"24 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that they have no conflicts of interest with the contents of the article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"107"}}