{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T05:29:53Z","timestamp":1768368593246,"version":"3.49.0"},"reference-count":160,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":32,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602796"],"award-info":[{"award-number":["81602796"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"DOI":"10.1007\/s10571-025-01650-1","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T17:05:26Z","timestamp":1765559126000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of c-Abl in Alzheimer\u2019s Disease: Guilty or not Guilty?"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-6190","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0375-1016","authenticated-orcid":false,"given":"Jiannan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"issue":"1","key":"1650_CR1","doi-asserted-by":"publisher","first-page":"101442","DOI":"10.1016\/j.jbc.2021.101442","volume":"298","author":"DM Acosta","year":"2022","unstructured":"Acosta DM, Mancinelli C, Bracken C, Eliezer D (2022) Post-translational modifications within Tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation. J Biol Chem 298(1):101442. https:\/\/doi.org\/10.1016\/j.jbc.2021.101442","journal-title":"J Biol Chem"},{"issue":"2","key":"1650_CR2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1158\/1541-7786.MCR-23-0493","volume":"22","author":"T Affandi","year":"2024","unstructured":"Affandi T, Haas A, Ohm AM, Wright GM, Black JC, Reyland ME (2024) PKCdelta regulates chromatin remodeling and DNA repair through SIRT6. Mol Cancer Res 22(2):181\u2013196. https:\/\/doi.org\/10.1158\/1541-7786.MCR-23-0493","journal-title":"Mol Cancer Res"},{"issue":"10","key":"1650_CR3","doi-asserted-by":"publisher","first-page":"4264","DOI":"10.1038\/s41380-022-01676-7","volume":"27","author":"C Alexander","year":"2022","unstructured":"Alexander C, Li T, Hattori Y, Chiu D, Frost GR, Jonas L, Liu C, Anderson CJ, Wong E, Park L, Iadecola C, Li YM (2022) Hypoxia inducible Factor-1alpha binds and activates gamma-secretase for Abeta production under hypoxia and cerebral hypoperfusion. Mol Psychiatry 27(10):4264\u20134273. https:\/\/doi.org\/10.1038\/s41380-022-01676-7","journal-title":"Mol Psychiatry"},{"issue":"23","key":"1650_CR4","doi-asserted-by":"publisher","first-page":"8864","DOI":"10.1073\/pnas.0603214103","volume":"103","author":"C Alonso Adel","year":"2006","unstructured":"Alonso Adel C, Li B, Grundke-Iqbal I, Iqbal K (2006) Polymerization of hyperphosphorylated Tau into filaments eliminates its inhibitory activity. Proc Natl Acad Sci U S A 103(23):8864\u20138869. https:\/\/doi.org\/10.1073\/pnas.0603214103","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"1650_CR5","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.nbd.2004.06.007","volume":"17","author":"AR Alvarez","year":"2004","unstructured":"Alvarez AR, Sandoval PC, Leal NR, Castro PU, Kosik KS (2004) Activation of the neuronal c-Abl tyrosine kinase by amyloid-beta-peptide and reactive oxygen species. Neurobiol Dis 17(2):326\u2013336. https:\/\/doi.org\/10.1016\/j.nbd.2004.06.007","journal-title":"Neurobiol Dis"},{"key":"1650_CR6","doi-asserted-by":"publisher","unstructured":"Bazzari FH, Bazzari AH (2022) BACE1 Inhibitors for Alzheimer\u2019s Disease: The Past. Present any Future? Molecules 27(24). https:\/\/doi.org\/10.3390\/molecules27248823","DOI":"10.3390\/molecules27248823"},{"issue":"7","key":"1650_CR7","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1089\/ars.2019.7905","volume":"33","author":"R Brigelius-Flohe","year":"2020","unstructured":"Brigelius-Flohe R, Flohe L (2020) Regulatory phenomena in the glutathione peroxidase superfamily. Antioxid Redox Signal 33(7):498\u2013516. https:\/\/doi.org\/10.1089\/ars.2019.7905","journal-title":"Antioxid Redox Signal"},{"issue":"12","key":"1650_CR8","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1021\/acscentsci.1c00585","volume":"7","author":"ZF Brotzakis","year":"2021","unstructured":"Brotzakis ZF, Lindstedt PR, Taylor RJ, Rinauro DJ, Gallagher NCT, Bernardes GJL, Vendruscolo M (2021) A structural ensemble of a Tau-Microtubule complex reveals regulatory Tau phosphorylation and acetylation mechanisms. ACS Cent Sci 7(12):1986\u20131995. https:\/\/doi.org\/10.1021\/acscentsci.1c00585","journal-title":"ACS Cent Sci"},{"key":"1650_CR9","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.freeradbiomed.2014.06.021","volume":"74","author":"M Buelna-Chontal","year":"2014","unstructured":"Buelna-Chontal M, Guevara-Chavez JG, Silva-Palacios A, Medina-Campos ON, Pedraza-Chaverri J, Zazueta C (2014) Nrf2-regulated antioxidant response is activated by protein kinase C in postconditioned rat hearts. Free Radic Biol Med 74:145\u2013156. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2014.06.021","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"1650_CR10","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1007\/s12264-022-00985-9","volume":"39","author":"W Cai","year":"2023","unstructured":"Cai W, Li L, Sang S, Pan X, Zhong C (2023) Physiological roles of beta-amyloid in regulating synaptic function: implications for AD pathophysiology. Neurosci Bull 39(8):1289\u20131308. https:\/\/doi.org\/10.1007\/s12264-022-00985-9","journal-title":"Neurosci Bull"},{"issue":"Pt 9","key":"1650_CR12","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1093\/brain\/awn125","volume":"131","author":"GI Cancino","year":"2008","unstructured":"Cancino GI, Toledo EM, Leal NR, Hernandez DE, Yevenes LF, Inestrosa NC, Alvarez AR (2008) STI571 prevents apoptosis, Tau phosphorylation and behavioural impairments induced by alzheimer\u2019s beta-amyloid deposits. Brain 131(Pt 9):2425\u20132442. https:\/\/doi.org\/10.1093\/brain\/awn125","journal-title":"Brain"},{"issue":"7","key":"1650_CR11","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.neurobiolaging.2009.07.007","volume":"32","author":"GI Cancino","year":"2011","unstructured":"Cancino GI, Perez de Arce K, Castro PU, Toledo EM, von Bernhardi R, Alvarez AR (2011) c-Abl tyrosine kinase modulates Tau pathology and Cdk5 phosphorylation in AD Transgenic mice. Neurobiol Aging 32(7):1249\u20131261. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2009.07.007","journal-title":"Neurobiol Aging"},{"issue":"7628","key":"1650_CR13","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature20412","volume":"539","author":"RG Canter","year":"2016","unstructured":"Canter RG, Penney J, Tsai LH (2016) The road to restoring neural circuits for the treatment of alzheimer\u2019s disease. Nature 539(7628):187\u2013196. https:\/\/doi.org\/10.1038\/nature20412","journal-title":"Nature"},{"issue":"41","key":"1650_CR14","doi-asserted-by":"publisher","first-page":"39609","DOI":"10.1074\/jbc.M305770200","volume":"278","author":"C Cao","year":"2003","unstructured":"Cao C, Leng Y, Huang W, Liu X, Kufe D (2003a) Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. J Biol Chem 278(41):39609\u201339614. https:\/\/doi.org\/10.1074\/jbc.M305770200","journal-title":"J Biol Chem"},{"issue":"32","key":"1650_CR15","doi-asserted-by":"publisher","first-page":"29667","DOI":"10.1074\/jbc.M301292200","volume":"278","author":"C Cao","year":"2003","unstructured":"Cao C, Leng Y, Kufe D (2003b) Catalase activity is regulated by c-Abl and Arg in the oxidative stress response. J Biol Chem 278(32):29667\u201329675. https:\/\/doi.org\/10.1074\/jbc.M301292200","journal-title":"J Biol Chem"},{"issue":"15","key":"1650_CR16","doi-asserted-by":"publisher","first-page":"12961","DOI":"10.1074\/jbc.M300058200","volume":"278","author":"C Cao","year":"2003","unstructured":"Cao C, Leng Y, Li C, Kufe D (2003c) Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response. J Biol Chem 278(15):12961\u201312967. https:\/\/doi.org\/10.1074\/jbc.M300058200","journal-title":"J Biol Chem"},{"issue":"35","key":"1650_CR17","doi-asserted-by":"publisher","first-page":"10348","DOI":"10.1021\/bi035023f","volume":"42","author":"C Cao","year":"2003","unstructured":"Cao C, Leng Y, Liu X, Yi Y, Li P, Kufe D (2003d) Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases. Biochemistry 42(35):10348\u201310353. https:\/\/doi.org\/10.1021\/bi035023f","journal-title":"Biochemistry"},{"issue":"2","key":"1650_CR18","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1177\/153331750602100213","volume":"21","author":"RJ Castellani","year":"2006","unstructured":"Castellani RJ, Lee HG, Perry G, Smith MA (2006) Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and Tau. Am J Alzheimers Dis Other Demen 21(2):126\u2013130. https:\/\/doi.org\/10.1177\/153331750602100213","journal-title":"Am J Alzheimers Dis Other Demen"},{"issue":"11","key":"1650_CR19","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.4103\/1673-5374.135317","volume":"9","author":"X Chai","year":"2014","unstructured":"Chai X, Kong W, Liu L, Yu W, Zhang Z, Sun Y (2014) A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis. Neural Regen Res 9(11):1145\u20131153. https:\/\/doi.org\/10.4103\/1673-5374.135317","journal-title":"Neural Regen Res"},{"issue":"18","key":"1650_CR20","doi-asserted-by":"publisher","first-page":"12748","DOI":"10.1074\/jbc.274.18.12748","volume":"274","author":"G Chen","year":"1999","unstructured":"Chen G, Yuan SS, Liu W, Xu Y, Trujillo K, Song B, Cong F, Goff SP, Wu Y, Arlinghaus R, Baltimore D, Gasser PJ, Park MS, Sung P, Lee EY (1999) Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl. J Biol Chem 274(18):12748\u201312752. https:\/\/doi.org\/10.1074\/jbc.274.18.12748","journal-title":"J Biol Chem"},{"key":"1650_CR21","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.nicl.2013.02.006","volume":"2","author":"G Chetelat","year":"2013","unstructured":"Chetelat G, La Joie R, Villain N, Perrotin A, de La Sayette V, Eustache F, Vandenberghe R (2013) Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical alzheimer\u2019s disease. Neuroimage Clin 2:356\u2013365. https:\/\/doi.org\/10.1016\/j.nicl.2013.02.006","journal-title":"Neuroimage Clin"},{"issue":"Pt 2","key":"1650_CR22","doi-asserted-by":"publisher","first-page":"145785","DOI":"10.1016\/j.ijbiomac.2025.145785","volume":"320","author":"A Choudhury","year":"2025","unstructured":"Choudhury A, Prabha S, Saeed MU, Mohammad T, Hussain A, AlAjmi MF, Khan FI, Islam A, Hassan MI (2025) Targeting Tau hyperphosphorylation-mediated neuroinflammation in alzheimer\u2019s disease via ABL1 kinase inhibition: insights from microsecond MD simulation and MM\/PBSA analyses. Int J Biol Macromol 320(Pt 2):145785. https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.145785","journal-title":"Int J Biol Macromol"},{"issue":"5","key":"1650_CR23","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3346\/jkms.2002.17.5.581","volume":"17","author":"YS Chun","year":"2002","unstructured":"Chun YS, Kim MS, Park JW (2002) Oxygen-dependent and -independent regulation of HIF-1alpha. J Korean Med Sci 17(5):581\u2013588. https:\/\/doi.org\/10.3346\/jkms.2002.17.5.581","journal-title":"J Korean Med Sci"},{"key":"1650_CR24","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.redox.2018.01.008","volume":"15","author":"JN Cobley","year":"2018","unstructured":"Cobley JN, Fiorello ML, Bailey DM (2018) 13 reasons why the brain is susceptible to oxidative stress. Redox Biol 15:490\u2013503. https:\/\/doi.org\/10.1016\/j.redox.2018.01.008","journal-title":"Redox Biol"},{"issue":"10","key":"1650_CR25","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1093\/molehr\/gaq045","volume":"16","author":"VA Codelia","year":"2010","unstructured":"Codelia VA, Cisterna M, Alvarez AR, Moreno RD (2010) p73 participates in male germ cells apoptosis induced by Etoposide. Mol Hum Reprod 16(10):734\u2013742. https:\/\/doi.org\/10.1093\/molehr\/gaq045","journal-title":"Mol Hum Reprod"},{"key":"1650_CR26","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1750-1326-2-22","volume":"2","author":"SL Cole","year":"2007","unstructured":"Cole SL, Vassar R (2007) The alzheimer\u2019s disease beta-secretase enzyme, BACE1. Mol Neurodegener 2:22. https:\/\/doi.org\/10.1186\/1750-1326-2-22","journal-title":"Mol Neurodegener"},{"issue":"139","key":"1650_CR27","doi-asserted-by":"publisher","first-page":"re6","DOI":"10.1126\/scisignal.3139re6","volume":"3","author":"J Colicelli","year":"2010","unstructured":"Colicelli J (2010) ABL tyrosine kinases: evolution of function, regulation, and specificity. Sci Signal 3(139):re6. https:\/\/doi.org\/10.1126\/scisignal.3139re6","journal-title":"Sci Signal"},{"issue":"5","key":"1650_CR28","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s00401-010-0716-8","volume":"120","author":"CM Cowan","year":"2010","unstructured":"Cowan CM, Bossing T, Page A, Shepherd D, Mudher A (2010) Soluble hyper-phosphorylated Tau causes microtubule breakdown and functionally compromises normal Tau in vivo. Acta Neuropathol 120(5):593\u2013604. https:\/\/doi.org\/10.1007\/s00401-010-0716-8","journal-title":"Acta Neuropathol"},{"issue":"26","key":"1650_CR29","doi-asserted-by":"publisher","first-page":"19439","DOI":"10.1074\/jbc.C000165200","volume":"275","author":"MP Cuajungco","year":"2000","unstructured":"Cuajungco MP, Goldstein LE, Nunomura A, Smith MA, Lim JT, Atwood CS, Huang X, Farrag YW, Perry G, Bush AI (2000) Evidence that the beta-amyloid plaques of alzheimer\u2019s disease represent the redox-silencing and entombment of Abeta by zinc. J Biol Chem 275(26):19439\u201319442. https:\/\/doi.org\/10.1074\/jbc.C000165200","journal-title":"J Biol Chem"},{"issue":"28","key":"1650_CR30","doi-asserted-by":"publisher","first-page":"6584","DOI":"10.1523\/JNEUROSCI.1487-05.2005","volume":"25","author":"P Derkinderen","year":"2005","unstructured":"Derkinderen P, Scales TM, Hanger DP, Leung KY, Byers HL, Ward MA, Lenz C, Price C, Bird IN, Perera T, Kellie S, Williamson R, Noble W, Van Etten RA, Leroy K, Brion JP, Reynolds CH, Anderton BH (2005) Tyrosine 394 is phosphorylated in alzheimer\u2019s paired helical filament Tau and in fetal Tau with c-Abl as the candidate tyrosine kinase. J Neurosci 25(28):6584\u20136593. https:\/\/doi.org\/10.1523\/JNEUROSCI.1487-05.2005","journal-title":"J Neurosci"},{"issue":"1","key":"1650_CR31","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","volume":"14","author":"MA DeTure","year":"2019","unstructured":"DeTure MA, Dickson DW (2019) The neuropathological diagnosis of alzheimer\u2019s disease. Mol Neurodegener 14(1):32. https:\/\/doi.org\/10.1186\/s13024-019-0333-5","journal-title":"Mol Neurodegener"},{"issue":"4","key":"1650_CR32","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41419-022-04748-2","volume":"13","author":"Q Dong","year":"2022","unstructured":"Dong Q, Li D, Zhao H, Zhang X, Liu Y, Hu Y, Yao Y, Zhu L, Wang GF, Liu H, Gao T, Niu X, Zheng T, Song C, Wang D, Bai Y, Jin J, Liu Z, Jin Y, Li P, Cao C, Liu X (2022) Anti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl kinase-involved ROS clearance. Cell Death Dis 13(4):298. https:\/\/doi.org\/10.1038\/s41419-022-04748-2","journal-title":"Cell Death Dis"},{"issue":"8","key":"1650_CR33","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1096\/fj.09-132928","volume":"23","author":"M Dumont","year":"2009","unstructured":"Dumont M, Wille E, Stack C, Calingasan NY, Beal MF, Lin MT (2009) Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a Transgenic mouse model of alzheimer\u2019s disease. FASEB J 23(8):2459\u20132466. https:\/\/doi.org\/10.1096\/fj.09-132928","journal-title":"FASEB J"},{"issue":"29","key":"1650_CR35","doi-asserted-by":"publisher","first-page":"eabo4459","DOI":"10.1126\/sciadv.abo4459","volume":"8","author":"N El Mammeri","year":"2022","unstructured":"El Mammeri N, Dregni AJ, Duan P, Wang HK, Hong M (2022) Microtubule-binding core of the Tau protein. Sci Adv 8(29):eabo4459. https:\/\/doi.org\/10.1126\/sciadv.abo4459","journal-title":"Sci Adv"},{"issue":"5495","key":"1650_CR34","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1126\/science.290.5495.1364","volume":"290","author":"AE El-Husseini","year":"2000","unstructured":"El-Husseini AE, Schnell E, Chetkovich DM, Nicoll RA, Bredt DS (2000) PSD-95 involvement in maturation of excitatory synapses. Science 290(5495):1364\u20131368","journal-title":"Science"},{"issue":"4959","key":"1650_CR36","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1126\/science.2111583","volume":"248","author":"FS Esch","year":"1990","unstructured":"Esch FS, Keim PS, Beattie EC, Blacher RW, Culwell AR, Oltersdorf T, McClure D, Ward PJ (1990) Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science 248(4959):1122\u20131124. https:\/\/doi.org\/10.1126\/science.2111583","journal-title":"Science"},{"issue":"3","key":"1650_CR37","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.3233\/JAD-151087","volume":"54","author":"LD Estrada","year":"2016","unstructured":"Estrada LD, Chamorro D, Yanez MJ, Gonzalez M, Leal N, von Bernhardi R, Dulcey AE, Marugan J, Ferrer M, Soto C, Zanlungo S, Inestrosa NC, Alvarez AR (2016) Reduction of blood Amyloid-beta oligomers in alzheimer\u2019s disease Transgenic mice by c-Abl kinase Inhibition. J Alzheimers Dis 54(3):1193\u20131205. https:\/\/doi.org\/10.3233\/JAD-151087","journal-title":"J Alzheimers Dis"},{"key":"1650_CR38","doi-asserted-by":"publisher","first-page":"100942","DOI":"10.1016\/j.arr.2019.100942","volume":"54","author":"L Fao","year":"2019","unstructured":"Fao L, Mota SI, Rego AC (2019) Shaping the Nrf2-ARE-related pathways in alzheimer\u2019s and parkinson\u2019s diseases. Ageing Res Rev 54:100942. https:\/\/doi.org\/10.1016\/j.arr.2019.100942","journal-title":"Ageing Res Rev"},{"issue":"2","key":"1650_CR39","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.pharmthera.2007.06.006","volume":"116","author":"MA Findeis","year":"2007","unstructured":"Findeis MA (2007) The role of amyloid beta peptide 42 in alzheimer\u2019s disease. Pharmacol Ther 116(2):266\u2013286. https:\/\/doi.org\/10.1016\/j.pharmthera.2007.06.006","journal-title":"Pharmacol Ther"},{"issue":"1","key":"1650_CR40","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3233\/JAD-2012-112186","volume":"30","author":"B Flammang","year":"2012","unstructured":"Flammang B, Pardossi-Piquard R, Sevalle J, Debayle D, Dabert-Gay AS, Thevenet A, Lauritzen I, Checler F (2012) Evidence that the amyloid-beta protein precursor intracellular domain, AICD, derives from beta-secretase-generated C-terminal fragment. J Alzheimers Dis 30(1):145\u2013153. https:\/\/doi.org\/10.3233\/JAD-2012-112186","journal-title":"J Alzheimers Dis"},{"issue":"12","key":"1650_CR41","doi-asserted-by":"publisher","first-page":"4020","DOI":"10.1128\/MCB.22.12.4020-4032.2002","volume":"22","author":"N Foray","year":"2002","unstructured":"Foray N, Marot D, Randrianarison V, Venezia ND, Picard D, Perricaudet M, Favaudon V, Jeggo P (2002) Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation. Mol Cell Biol 22(12):4020\u20134032. https:\/\/doi.org\/10.1128\/MCB.22.12.4020-4032.2002","journal-title":"Mol Cell Biol"},{"issue":"6","key":"1650_CR42","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1046\/j.1471-4159.1994.63062288.x","volume":"63","author":"TF Frappier","year":"1994","unstructured":"Frappier TF, Georgieff IS, Brown K, Shelanski ML (1994) Tau regulation of microtubule-microtubule spacing and bundling. J Neurochem 63(6):2288\u20132294. https:\/\/doi.org\/10.1046\/j.1471-4159.1994.63062288.x","journal-title":"J Neurochem"},{"issue":"27","key":"1650_CR43","doi-asserted-by":"publisher","first-page":"9959","DOI":"10.1073\/pnas.1405803111","volume":"111","author":"AK Fu","year":"2014","unstructured":"Fu AK, Hung KW, Huang H, Gu S, Shen Y, Cheng EY, Ip FC, Huang X, Fu WY, Ip NY (2014) Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of alzheimer\u2019s disease. Proc Natl Acad Sci U S A 111(27):9959\u20139964. https:\/\/doi.org\/10.1073\/pnas.1405803111","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"34","key":"1650_CR44","doi-asserted-by":"publisher","first-page":"10582","DOI":"10.1523\/JNEUROSCI.1736-09.2009","volume":"29","author":"ML Giuffrida","year":"2009","unstructured":"Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A (2009) Beta-amyloid monomers are neuroprotective. J Neurosci 29(34):10582\u201310587. https:\/\/doi.org\/10.1523\/JNEUROSCI.1736-09.2009","journal-title":"J Neurosci"},{"issue":"1","key":"1650_CR45","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/ana.410410106","volume":"41","author":"T Gomez-Isla","year":"1997","unstructured":"Gomez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, Parisi JE, Hyman BT (1997) Neuronal loss correlates with but exceeds neurofibrillary tangles in alzheimer\u2019s disease. Ann Neurol 41(1):17\u201324. https:\/\/doi.org\/10.1002\/ana.410410106","journal-title":"Ann Neurol"},{"issue":"10","key":"1650_CR46","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1038\/nm.2033","volume":"15","author":"S Gonfloni","year":"2009","unstructured":"Gonfloni S, Di Tella L, Caldarola S, Cannata SM, Klinger FG, Di Bartolomeo C, Mattei M, Candi E, De Felici M, Melino G, Cesareni G (2009) Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. Nat Med 15(10):1179\u20131185. https:\/\/doi.org\/10.1038\/nm.2033","journal-title":"Nat Med"},{"issue":"1","key":"1650_CR47","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.molcel.2014.08.013","volume":"56","author":"M Gonzalez-Zuniga","year":"2014","unstructured":"Gonzalez-Zuniga M, Contreras PS, Estrada LD, Chamorro D, Villagra A, Zanlungo S, Seto E, Alvarez AR (2014) c-Abl stabilizes HDAC2 levels by tyrosine phosphorylation repressing neuronal gene expression in alzheimer\u2019s disease. Mol Cell 56(1):163\u2013173. https:\/\/doi.org\/10.1016\/j.molcel.2014.08.013","journal-title":"Mol Cell"},{"issue":"7243","key":"1650_CR48","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature07925","volume":"459","author":"JS Guan","year":"2009","unstructured":"Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai LH (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459(7243):55\u201360. https:\/\/doi.org\/10.1038\/nature07925","journal-title":"Nature"},{"key":"1650_CR50","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3389\/fncel.2019.00526","volume":"13","author":"DA Gutierrez","year":"2019","unstructured":"Gutierrez DA, Vargas LM, Chandia-Cristi A, de la Fuente C, Leal N, Alvarez AR (2019) c-Abl deficiency provides synaptic resiliency against Abeta-Oligomers. Front Cell Neurosci 13:526. https:\/\/doi.org\/10.3389\/fncel.2019.00526","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"1650_CR49","doi-asserted-by":"publisher","first-page":"237","DOI":"10.4103\/1673-5374.346540","volume":"18","author":"DA Gutierrez","year":"2023","unstructured":"Gutierrez DA, Chandia-Cristi A, Yanez MJ, Zanlungo S, Alvarez AR (2023) c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases. Neural Regen Res 18(2):237\u2013243. https:\/\/doi.org\/10.4103\/1673-5374.346540","journal-title":"Neural Regen Res"},{"issue":"6378","key":"1650_CR51","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/357500a0","volume":"357","author":"C Haass","year":"1992","unstructured":"Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ (1992) Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357(6378):500\u2013503. https:\/\/doi.org\/10.1038\/357500a0","journal-title":"Nature"},{"issue":"10","key":"1650_CR52","doi-asserted-by":"publisher","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","volume":"26","author":"H Hampel","year":"2021","unstructured":"Hampel H, Hardy J, Blennow K, Chen C, Perry G, Kim SH, Villemagne VL, Aisen P, Vendruscolo M, Iwatsubo T, Masters CL, Cho M, Lannfelt L, Cummings JL, Vergallo A (2021) The Amyloid-beta pathway in alzheimer\u2019s disease. Mol Psychiatry 26(10):5481\u20135503. https:\/\/doi.org\/10.1038\/s41380-021-01249-0","journal-title":"Mol Psychiatry"},{"issue":"1","key":"1650_CR53","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrm1280","volume":"5","author":"O Hantschel","year":"2004","unstructured":"Hantschel O, Superti-Furga G (2004) Regulation of the c-Abl and Bcr-Abl tyrosine kinases. Nat Rev Mol Cell Biol 5(1):33\u201344. https:\/\/doi.org\/10.1038\/nrm1280","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5054","key":"1650_CR55","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1126\/science.1566067","volume":"256","author":"JA Hardy","year":"1992","unstructured":"Hardy JA, Higgins GA (1992) Alzheimer\u2019s disease: the amyloid cascade hypothesis. Science 256(5054):184\u2013185. https:\/\/doi.org\/10.1126\/science.1566067","journal-title":"Science"},{"issue":"5580","key":"1650_CR54","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","volume":"297","author":"J Hardy","year":"2002","unstructured":"Hardy J, Selkoe DJ (2002) The amyloid hypothesis of alzheimer\u2019s disease: progress and problems on the road to therapeutics. Science 297(5580):353\u2013356. https:\/\/doi.org\/10.1126\/science.1072994","journal-title":"Science"},{"key":"1650_CR56","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fnmol.2017.00022","volume":"10","author":"D Hefter","year":"2017","unstructured":"Hefter D, Draguhn A (2017) APP as a protective factor in acute neuronal insults. Front Mol Neurosci 10:22. https:\/\/doi.org\/10.3389\/fnmol.2017.00022","journal-title":"Front Mol Neurosci"},{"issue":"16","key":"1650_CR57","doi-asserted-by":"publisher","first-page":"3368","DOI":"10.1038\/emboj.2011.238","volume":"30","author":"M Honda","year":"2011","unstructured":"Honda M, Okuno Y, Yoo J, Ha T, Spies M (2011) Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding. EMBO J 30(16):3368\u20133382. https:\/\/doi.org\/10.1038\/emboj.2011.238","journal-title":"EMBO J"},{"issue":"6","key":"1650_CR58","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1093\/nar\/gkaa006","volume":"48","author":"T Hou","year":"2020","unstructured":"Hou T, Cao Z, Zhang J, Tang M, Tian Y, Li Y, Lu X, Chen Y, Wang H, Wei FZ, Wang L, Yang Y, Zhao Y, Wang Z, Wang H, Zhu WG (2020) SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair. Nucleic Acids Res 48(6):2982\u20133000. https:\/\/doi.org\/10.1093\/nar\/gkaa006","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"1650_CR59","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12929-019-0609-7","volume":"27","author":"LK Huang","year":"2020","unstructured":"Huang LK, Chao SP, Hu CJ (2020) Clinical trials of new drugs for alzheimer disease. J Biomed Sci 27(1):18. https:\/\/doi.org\/10.1186\/s12929-019-0609-7","journal-title":"J Biomed Sci"},{"issue":"18","key":"1650_CR60","doi-asserted-by":"publisher","first-page":"6233","DOI":"10.1128\/MCB.21.18.6233-6242.2001","volume":"21","author":"Y Ito","year":"2001","unstructured":"Ito Y, Pandey P, Mishra N, Kumar S, Narula N, Kharbanda S, Saxena S, Kufe D (2001) Targeting of the c-Abl tyrosine kinase to mitochondria in Endoplasmic reticulum stress-induced apoptosis. Mol Cell Biol 21(18):6233\u20136242. https:\/\/doi.org\/10.1128\/MCB.21.18.6233-6242.2001","journal-title":"Mol Cell Biol"},{"issue":"5516","key":"1650_CR61","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1126\/science.1059796","volume":"292","author":"P Jaakkola","year":"2001","unstructured":"Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated Prolyl hydroxylation. Science 292(5516):468\u2013472. https:\/\/doi.org\/10.1126\/science.1059796","journal-title":"Science"},{"issue":"5","key":"1650_CR62","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1177\/1073858404263456","volume":"10","author":"WB Jacobs","year":"2004","unstructured":"Jacobs WB, Walsh GS, Miller FD (2004) Neuronal survival and p73\/p63\/p53: a family affair. Neuroscientist 10(5):443\u2013455. https:\/\/doi.org\/10.1177\/1073858404263456","journal-title":"Neuroscientist"},{"issue":"11","key":"1650_CR63","doi-asserted-by":"publisher","first-page":"4877","DOI":"10.1038\/s41380-023-02145-5","volume":"28","author":"M Jin","year":"2023","unstructured":"Jin M, Wei Z, Ramalingam N, Xiao M, Xu A, Yu X, Song Q, Liu W, Zhao J, Zhang D, Selkoe DJ, Li S (2023) Activation of beta(2)-adrenergic receptors prevents AD-type synaptotoxicity via epigenetic mechanisms. Mol Psychiatry 28(11):4877\u20134888. https:\/\/doi.org\/10.1038\/s41380-023-02145-5","journal-title":"Mol Psychiatry"},{"issue":"39","key":"1650_CR64","doi-asserted-by":"publisher","first-page":"8510","DOI":"10.1523\/JNEUROSCI.1264-04.2004","volume":"24","author":"SB Jones","year":"2004","unstructured":"Jones SB, Lu HY, Lu Q (2004) Abl tyrosine kinase promotes dendrogenesis by inducing actin cytoskeletal rearrangements in Cooperation with Rho family small GTPases in hippocampal neurons. J Neurosci 24(39):8510\u20138521. https:\/\/doi.org\/10.1523\/JNEUROSCI.1264-04.2004","journal-title":"J Neurosci"},{"key":"1650_CR65","doi-asserted-by":"publisher","first-page":"25628","DOI":"10.1038\/srep25628","volume":"6","author":"ES Jung","year":"2016","unstructured":"Jung ES, Choi H, Song H, Hwang YJ, Kim A, Ryu H, Mook-Jung I (2016) p53-dependent SIRT6 expression protects Abeta42-induced DNA damage. Sci Rep 6:25628. https:\/\/doi.org\/10.1038\/srep25628","journal-title":"Sci Rep"},{"key":"1650_CR67","doi-asserted-by":"publisher","unstructured":"Kim Y, Jang HH (2019) Role of cytosolic 2-Cys Prx1 and Prx2 in redox signaling. Antioxid (Basel) 8(6). https:\/\/doi.org\/10.3390\/antiox8060169","DOI":"10.3390\/antiox8060169"},{"issue":"10","key":"1650_CR66","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nrn1517","volume":"5","author":"E Kim","year":"2004","unstructured":"Kim E, Sheng M (2004) PDZ domain proteins of synapses. Nat Rev Neurosci 5(10):771\u2013781. https:\/\/doi.org\/10.1038\/nrn1517","journal-title":"Nat Rev Neurosci"},{"issue":"50","key":"1650_CR68","doi-asserted-by":"publisher","first-page":"48944","DOI":"10.1074\/jbc.M208151200","volume":"277","author":"H Kitao","year":"2002","unstructured":"Kitao H, Yuan ZM (2002) Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation. J Biol Chem 277(50):48944\u201348948. https:\/\/doi.org\/10.1074\/jbc.M208151200","journal-title":"J Biol Chem"},{"issue":"4","key":"1650_CR69","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1007\/s00401-001-0477-5","volume":"103","author":"JJ Kril","year":"2002","unstructured":"Kril JJ, Patel S, Harding AJ, Halliday GM (2002) Neuron loss from the hippocampus of alzheimer\u2019s disease exceeds extracellular neurofibrillary tangle formation. Acta Neuropathol 103(4):370\u2013376. https:\/\/doi.org\/10.1007\/s00401-001-0477-5","journal-title":"Acta Neuropathol"},{"issue":"20","key":"1650_CR70","doi-asserted-by":"publisher","first-page":"17281","DOI":"10.1074\/jbc.M101414200","volume":"276","author":"S Kumar","year":"2001","unstructured":"Kumar S, Bharti A, Mishra NC, Raina D, Kharbanda S, Saxena S, Kufe D (2001) Targeting of the c-Abl tyrosine kinase to mitochondria in the necrotic cell death response to oxidative stress. J Biol Chem 276(20):17281\u201317285. https:\/\/doi.org\/10.1074\/jbc.M101414200","journal-title":"J Biol Chem"},{"key":"1650_CR71","doi-asserted-by":"publisher","first-page":"102031","DOI":"10.1016\/j.pneurobio.2021.102031","volume":"202","author":"L La Barbera","year":"2021","unstructured":"La Barbera L, Vedele F, Nobili A, Krashia P, Spoleti E, Latagliata EC, Cutuli D, Cauzzi E, Marino R, Viscomi MT, Petrosini L, Puglisi-Allegra S, Melone M, Keller F, Mercuri NB, Conti F, D\u2019Amelio M (2021) Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of alzheimer\u2019s disease. Prog Neurobiol 202:102031. https:\/\/doi.org\/10.1016\/j.pneurobio.2021.102031","journal-title":"Prog Neurobiol"},{"issue":"5","key":"1650_CR72","doi-asserted-by":"publisher","first-page":"118664","DOI":"10.1016\/j.bbamcr.2020.118664","volume":"1867","author":"E Lauretti","year":"2020","unstructured":"Lauretti E, Dincer O, Pratico D (2020) Glycogen synthase kinase-3 signaling in alzheimer\u2019s disease. Biochim Biophys Acta Mol Cell Res 1867(5):118664. https:\/\/doi.org\/10.1016\/j.bbamcr.2020.118664","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"1","key":"1650_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/JAD-2009-1116","volume":"18","author":"T Lebouvier","year":"2009","unstructured":"Lebouvier T, Scales TM, Williamson R, Noble W, Duyckaerts C, Hanger DP, Reynolds CH, Anderton BH, Derkinderen P (2009) The microtubule-associated protein Tau is also phosphorylated on tyrosine. J Alzheimers Dis 18(1):1\u20139. https:\/\/doi.org\/10.3233\/JAD-2009-1116","journal-title":"J Alzheimers Dis"},{"issue":"28","key":"1650_CR74","doi-asserted-by":"publisher","first-page":"19826","DOI":"10.1074\/jbc.M706201200","volume":"283","author":"JH Lee","year":"2008","unstructured":"Lee JH, Jeong MW, Kim W, Choi YH, Kim KT (2008) Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress. J Biol Chem 283(28):19826\u201319835. https:\/\/doi.org\/10.1074\/jbc.M706201200","journal-title":"J Biol Chem"},{"key":"1650_CR75","doi-asserted-by":"publisher","first-page":"1180987","DOI":"10.3389\/fnagi.2023.1180987","volume":"15","author":"R Leon","year":"2023","unstructured":"Leon R, Gutierrez DA, Pinto C, Morales C, de la Fuente C, Riquelme C, Cortes BI, Gonzalez-Martin A, Chamorro D, Espinosa N, Fuentealba P, Cancino GI, Zanlungo S, Dulcey AE, Marugan JJ, Alvarez Rojas A (2023) c-Abl tyrosine kinase down-regulation as target for memory improvement in alzheimer\u2019s disease. Front Aging Neurosci 15:1180987. https:\/\/doi.org\/10.3389\/fnagi.2023.1180987","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"1650_CR76","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.molcel.2007.12.022","volume":"29","author":"D Levy","year":"2008","unstructured":"Levy D, Adamovich Y, Reuven N, Shaul Y (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell 29(3):350\u2013361. https:\/\/doi.org\/10.1016\/j.molcel.2007.12.022","journal-title":"Mol Cell"},{"issue":"15","key":"1650_CR77","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1101\/gad.1223504","volume":"18","author":"B Li","year":"2004","unstructured":"Li B, Wang X, Rasheed N, Hu Y, Boast S, Ishii T, Nakayama K, Nakayama KI, Goff SP (2004) Distinct roles of c-Abl and atm in oxidative stress response are mediated by protein kinase C delta. Genes Dev 18(15):1824\u20131837. https:\/\/doi.org\/10.1101\/gad.1223504","journal-title":"Genes Dev"},{"issue":"1","key":"1650_CR78","doi-asserted-by":"publisher","first-page":"54","DOI":"10.4103\/NRR.NRR-D-23-01827","volume":"20","author":"JZ Li","year":"2025","unstructured":"Li JZ, Ramalingam N, Li S (2025) Targeting epigenetic mechanisms in amyloid-beta-mediated alzheimer\u2019s pathophysiology: unveiling therapeutic potential. Neural Regen Res 20(1):54\u201366. https:\/\/doi.org\/10.4103\/NRR.NRR-D-23-01827","journal-title":"Neural Regen Res"},{"issue":"3","key":"1650_CR79","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/sj.cdd.4402033","volume":"14","author":"H Lin","year":"2007","unstructured":"Lin H, Lin TY, Juang JL (2007) Abl deregulates Cdk5 kinase activity and subcellular localization in drosophila neurodegeneration. Cell Death Differ 14(3):607\u2013615. https:\/\/doi.org\/10.1038\/sj.cdd.4402033","journal-title":"Cell Death Differ"},{"issue":"10","key":"1650_CR80","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1016\/j.freeradbiomed.2007.02.015","volume":"42","author":"SI Liochev","year":"2007","unstructured":"Liochev SI, Fridovich I (2007) The effects of superoxide dismutase on H2O2 formation. Free Radic Biol Med 42(10):1465\u20131469. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2007.02.015","journal-title":"Free Radic Biol Med"},{"key":"1650_CR81","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41392-019-0063-8","volume":"4","author":"PP Liu","year":"2019","unstructured":"Liu PP, Xie Y, Meng XY, Kang JS (2019) History and progress of hypotheses and clinical trials for alzheimer\u2019s disease. Signal Transduct Target Ther 4:29. https:\/\/doi.org\/10.1038\/s41392-019-0063-8","journal-title":"Signal Transduct Target Ther"},{"key":"1650_CR82","doi-asserted-by":"publisher","first-page":"102389","DOI":"10.1016\/j.redox.2022.102389","volume":"54","author":"S Liu","year":"2022","unstructured":"Liu S, Pi J, Zhang Q (2022) Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway. Redox Biol 54:102389. https:\/\/doi.org\/10.1016\/j.redox.2022.102389","journal-title":"Redox Biol"},{"key":"1650_CR83","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.neuroscience.2015.07.070","volume":"304","author":"I Lonskaya","year":"2015","unstructured":"Lonskaya I, Hebron ML, Selby ST, Turner RS, Moussa CE (2015) Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in alzheimer\u2019s disease models. Neuroscience 304:316\u2013327. https:\/\/doi.org\/10.1016\/j.neuroscience.2015.07.070","journal-title":"Neuroscience"},{"issue":"22","key":"1650_CR84","doi-asserted-by":"publisher","first-page":"7497","DOI":"10.1093\/nar\/gkm821","volume":"35","author":"MA Lovell","year":"2007","unstructured":"Lovell MA, Markesbery WR (2007) Oxidative DNA damage in mild cognitive impairment and late-stage alzheimer\u2019s disease. Nucleic Acids Res 35(22):7497\u20137504. https:\/\/doi.org\/10.1093\/nar\/gkm821","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"1650_CR85","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/s0960-9822(00)00246-3","volume":"4","author":"S Lovestone","year":"1994","unstructured":"Lovestone S, Reynolds CH, Latimer D, Davis DR, Anderton BH, Gallo JM, Hanger D, Mulot S, Marquardt B, Stabel S et al (1994) Alzheimer\u2019s disease-like phosphorylation of the microtubule-associated protein Tau by glycogen synthase kinase-3 in transfected mammalian cells. Curr Biol 4(12):1077\u20131086. https:\/\/doi.org\/10.1016\/s0960-9822(00)00246-3","journal-title":"Curr Biol"},{"key":"1650_CR86","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","volume":"53","author":"Q Ma","year":"2013","unstructured":"Ma Q (2013) Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol 53:401\u2013426. https:\/\/doi.org\/10.1146\/annurev-pharmtox-011112-140320","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"7","key":"1650_CR87","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1016\/j.cell.2015.05.032","volume":"161","author":"R Madabhushi","year":"2015","unstructured":"Madabhushi R, Gao F, Pfenning AR, Pan L, Yamakawa S, Seo J, Rueda R, Phan TX, Yamakawa H, Pao PC, Stott RT, Gjoneska E, Nott A, Cho S, Kellis M, Tsai LH (2015) Activity-Induced DNA breaks govern the expression of neuronal Early-Response genes. Cell 161(7):1592\u20131605. https:\/\/doi.org\/10.1016\/j.cell.2015.05.032","journal-title":"Cell"},{"issue":"6","key":"1650_CR88","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s11011-025-01664-0","volume":"40","author":"A Mannan","year":"2025","unstructured":"Mannan A, Singh S, Mohan M, Singh TG (2025) Exploration of Imatinib involved in amyloidogenesis as a common foundation for type-2 diabetes mellitus (T2DM) and alzheimer\u2019s disease (AD). Metab Brain Dis 40(6):242. https:\/\/doi.org\/10.1007\/s11011-025-01664-0","journal-title":"Metab Brain Dis"},{"issue":"9","key":"1650_CR89","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1089\/neu.2011.1759","volume":"28","author":"RC Mannix","year":"2011","unstructured":"Mannix RC, Zhang J, Park J, Lee C, Whalen MJ (2011) Detrimental effect of genetic Inhibition of B-site APP-cleaving enzyme 1 on functional outcome after controlled cortical impact in young adult mice. J Neurotrauma 28(9):1855\u20131861. https:\/\/doi.org\/10.1089\/neu.2011.1759","journal-title":"J Neurotrauma"},{"issue":"45","key":"1650_CR90","doi-asserted-by":"publisher","first-page":"E9645","DOI":"10.1073\/pnas.1707151114","volume":"114","author":"T Mano","year":"2017","unstructured":"Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, Tamaoka A, Ikeuchi T, Saido TC, Iwatsubo T, Ushijima T, Murayama S, Hasegawa M, Iwata A (2017) Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in alzheimer\u2019s disease. Proc Natl Acad Sci U S A 114(45):E9645\u2013E9654. https:\/\/doi.org\/10.1073\/pnas.1707151114","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"29","key":"1650_CR91","doi-asserted-by":"publisher","first-page":"11800","DOI":"10.1073\/pnas.1200583109","volume":"109","author":"Z Mao","year":"2012","unstructured":"Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A (2012) Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci U S A 109(29):11800\u201311805. https:\/\/doi.org\/10.1073\/pnas.1200583109","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11\u201312","key":"1650_CR92","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1089\/ars.2006.8.2039","volume":"8","author":"WR Markesbery","year":"2006","unstructured":"Markesbery WR, Lovell MA (2006) DNA oxidation in alzheimer\u2019s disease. Antioxid Redox Signal 8(11\u201312):2039\u20132045. https:\/\/doi.org\/10.1089\/ars.2006.8.2039","journal-title":"Antioxid Redox Signal"},{"key":"1650_CR93","doi-asserted-by":"publisher","first-page":"15056","DOI":"10.1038\/nrdp.2015.56","volume":"1","author":"CL Masters","year":"2015","unstructured":"Masters CL, Bateman R, Blennow K, Rowe CC, Sperling RA, Cummings JL (2015) Alzheimer\u2019s disease. Nat Rev Dis Primers 1:15056. https:\/\/doi.org\/10.1038\/nrdp.2015.56","journal-title":"Nat Rev Dis Primers"},{"issue":"16","key":"1650_CR94","doi-asserted-by":"publisher","first-page":"e2210418120","DOI":"10.1073\/pnas.2210418120","volume":"120","author":"B Mayro","year":"2023","unstructured":"Mayro B, Hoj JP, Cerda-Smith CG, Hutchinson HM, Caminear MW, Thrash HL, Winter PS, Wardell SE, McDonnell DP, Wu C, Wood KC, Pendergast AM (2023) ABL kinases regulate the stabilization of HIF-1alpha and MYC through CPSF1. Proc Natl Acad Sci U S A 120(16):e2210418120. https:\/\/doi.org\/10.1073\/pnas.2210418120","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"1650_CR95","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/cdd.2010.132","volume":"18","author":"V Meltser","year":"2011","unstructured":"Meltser V, Ben-Yehoyada M, Shaul Y (2011) c-Abl tyrosine kinase in the DNA damage response: cell death and more. Cell Death Differ 18(1):2\u20134. https:\/\/doi.org\/10.1038\/cdd.2010.132","journal-title":"Cell Death Differ"},{"issue":"10","key":"1650_CR96","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.2174\/1570159X16666180110130253","volume":"16","author":"A Merelli","year":"2018","unstructured":"Merelli A, Rodriguez JCG, Folch J, Regueiro MR, Camins A, Lazarowski A (2018) Understanding the role of hypoxia inducible factor during neurodegeneration for new therapeutics opportunities. Curr Neuropharmacol 16(10):1484\u20131498. https:\/\/doi.org\/10.2174\/1570159X16666180110130253","journal-title":"Curr Neuropharmacol"},{"key":"1650_CR97","doi-asserted-by":"publisher","unstructured":"Merlo S, Spampinato SF, Lim D (2021) Molecular Aspects of Cellular Dysfunction in Alzheimer\u2019s Disease: The Need for a Holistic View of the Early Pathogenesis. Biomolecules 11(12). https:\/\/doi.org\/10.3390\/biom11121807","DOI":"10.3390\/biom11121807"},{"issue":"3","key":"1650_CR98","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1002\/jnr.10355","volume":"70","author":"M Morishima-Kawashima","year":"2002","unstructured":"Morishima-Kawashima M, Ihara Y (2002) Alzheimer\u2019s disease: beta-Amyloid protein and Tau. J Neurosci Res 70(3):392\u2013401. https:\/\/doi.org\/10.1002\/jnr.10355","journal-title":"J Neurosci Res"},{"issue":"5","key":"1650_CR99","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00401-018-1918-8","volume":"136","author":"GP Morris","year":"2018","unstructured":"Morris GP, Clark IA, Vissel B (2018) Questions concerning the role of amyloid-beta in the definition, aetiology and diagnosis of alzheimer\u2019s disease. Acta Neuropathol 136(5):663\u2013689. https:\/\/doi.org\/10.1007\/s00401-018-1918-8","journal-title":"Acta Neuropathol"},{"issue":"21","key":"1650_CR100","doi-asserted-by":"publisher","first-page":"12444","DOI":"10.1073\/pnas.1534745100","volume":"100","author":"WJ Netzer","year":"2003","unstructured":"Netzer WJ, Dou F, Cai D, Veach D, Jean S, Li Y, Bornmann WG, Clarkson B, Xu H, Greengard P (2003) Gleevec inhibits beta-amyloid production but not Notch cleavage. Proc Natl Acad Sci U S A 100(21):12444\u201312449. https:\/\/doi.org\/10.1073\/pnas.1534745100","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"1650_CR101","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1007\/s12035-015-9337-5","volume":"53","author":"E Niedzielska","year":"2016","unstructured":"Niedzielska E, Smaga I, Gawlik M, Moniczewski A, Stankowicz P, Pera J, Filip M (2016) Oxidative stress in neurodegenerative diseases. Mol Neurobiol 53(6):4094\u20134125. https:\/\/doi.org\/10.1007\/s12035-015-9337-5","journal-title":"Mol Neurobiol"},{"key":"1650_CR102","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.freeradbiomed.2013.02.008","volume":"66","author":"SK Niture","year":"2014","unstructured":"Niture SK, Khatri R, Jaiswal AK (2014) Regulation of Nrf2-an update. Free Radic Biol Med 66:36\u201344. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2013.02.008","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"1650_CR103","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1093\/jnen\/60.8.759","volume":"60","author":"A Nunomura","year":"2001","unstructured":"Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA (2001) Oxidative damage is the earliest event in alzheimer disease. J Neuropathol Exp Neurol 60(8):759\u2013767. https:\/\/doi.org\/10.1093\/jnen\/60.8.759","journal-title":"J Neuropathol Exp Neurol"},{"issue":"5885","key":"1650_CR104","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/299744a0","volume":"299","author":"B Ozanne","year":"1982","unstructured":"Ozanne B, Wheeler T, Zack J, Smith G, Dale B (1982) Transforming gene of a human leukaemia cell is unrelated to the expressed tumour virus related gene of the cell. Nature 299(5885):744\u2013747. https:\/\/doi.org\/10.1038\/299744a0","journal-title":"Nature"},{"issue":"Pt 1","key":"1650_CR105","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1113\/jphysiol.2006.111203","volume":"575","author":"HA Pearson","year":"2006","unstructured":"Pearson HA, Peers C (2006) Physiological roles for amyloid beta peptides. J Physiol 575(Pt 1):5\u201310. https:\/\/doi.org\/10.1113\/jphysiol.2006.111203","journal-title":"J Physiol"},{"key":"1650_CR106","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/s0065-230x(02)85003-5","volume":"85","author":"AM Pendergast","year":"2002","unstructured":"Pendergast AM (2002) The Abl family kinases: mechanisms of regulation and signaling. Adv Cancer Res 85:51\u2013100. https:\/\/doi.org\/10.1016\/s0065-230x(02)85003-5","journal-title":"Adv Cancer Res"},{"issue":"10","key":"1650_CR107","doi-asserted-by":"publisher","first-page":"3728","DOI":"10.1523\/JNEUROSCI.2024-09.2010","volume":"30","author":"K Perez de Arce","year":"2010","unstructured":"Perez de Arce K, Varela-Nallar L, Farias O, Cifuentes A, Bull P, Couch BA, Koleske AJ, Inestrosa NC, Alvarez AR (2010) Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. J Neurosci 30(10):3728\u20133738. https:\/\/doi.org\/10.1523\/JNEUROSCI.2024-09.2010","journal-title":"J Neurosci"},{"issue":"21","key":"1650_CR108","doi-asserted-by":"publisher","first-page":"22084","DOI":"10.1074\/jbc.M311479200","volume":"279","author":"MS Perkinton","year":"2004","unstructured":"Perkinton MS, Standen CL, Lau KF, Kesavapany S, Byers HL, Ward M, McLoughlin DM, Miller CC (2004) The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65\/amyloid precursor protein nuclear signaling. J Biol Chem 279(21):22084\u201322091. https:\/\/doi.org\/10.1074\/jbc.M311479200","journal-title":"J Biol Chem"},{"issue":"11","key":"1650_CR109","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1016\/s0891-5849(02)01113-9","volume":"33","author":"G Perry","year":"2002","unstructured":"Perry G, Nunomura A, Hirai K, Zhu X, Perez M, Avila J, Castellani RJ, Atwood CS, Aliev G, Sayre LM, Takeda A, Smith MA (2002) Is oxidative damage the fundamental pathogenic mechanism of alzheimer\u2019s and other neurodegenerative diseases? Free Radic Biol Med 33(11):1475\u20131479. https:\/\/doi.org\/10.1016\/s0891-5849(02)01113-9","journal-title":"Free Radic Biol Med"},{"issue":"12","key":"1650_CR110","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1016\/j.febslet.2009.04.044","volume":"583","author":"M Popova","year":"2009","unstructured":"Popova M, Shimizu H, Yamamoto K, Lebechec M, Takahashi M, Fleury F (2009) Detection of c-Abl kinase-promoted phosphorylation of Rad51 by specific antibodies reveals that Y54 phosphorylation is dependent on that of Y315. FEBS Lett 583(12):1867\u20131872. https:\/\/doi.org\/10.1016\/j.febslet.2009.04.044","journal-title":"FEBS Lett"},{"key":"1650_CR111","doi-asserted-by":"publisher","unstructured":"Provasek VE, Mitra J, Malojirao VH, Hegde ML (2022) DNA Double-Strand breaks as pathogenic lesions in neurological disorders. Int J Mol Sci 23(9). https:\/\/doi.org\/10.3390\/ijms23094653","DOI":"10.3390\/ijms23094653"},{"issue":"2","key":"1650_CR112","doi-asserted-by":"publisher","first-page":"111","DOI":"10.31887\/DCNS.2009.11.2\/cqiu","volume":"11","author":"C Qiu","year":"2009","unstructured":"Qiu C, Kivipelto M, von Strauss E (2009) Epidemiology of alzheimer\u2019s disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci 11(2):111\u2013128. https:\/\/doi.org\/10.31887\/DCNS.2009.11.2\/cqiu","journal-title":"Dialogues Clin Neurosci"},{"key":"1650_CR113","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1750-1326-2-12","volume":"2","author":"CA Rankin","year":"2007","unstructured":"Rankin CA, Sun Q, Gamblin TC (2007) Tau phosphorylation by GSK-3beta promotes tangle-like filament morphology. Mol Neurodegener 2:12. https:\/\/doi.org\/10.1186\/1750-1326-2-12","journal-title":"Mol Neurodegener"},{"issue":"3","key":"1650_CR114","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s10571-020-00858-7","volume":"41","author":"M Reichenstein","year":"2021","unstructured":"Reichenstein M, Borovok N, Sheinin A, Brider T, Michaelevski I (2021) Abelson kinases mediate the depression of spontaneous synaptic activity induced by amyloid beta 1\u201342 peptides. Cell Mol Neurobiol 41(3):431\u2013448. https:\/\/doi.org\/10.1007\/s10571-020-00858-7","journal-title":"Cell Mol Neurobiol"},{"issue":"4","key":"1650_CR115","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.bcp.2013.12.024","volume":"88","author":"C Reitz","year":"2014","unstructured":"Reitz C, Mayeux R (2014) Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers. Biochem Pharmacol 88(4):640\u2013651. https:\/\/doi.org\/10.1016\/j.bcp.2013.12.024","journal-title":"Biochem Pharmacol"},{"key":"1650_CR116","doi-asserted-by":"publisher","first-page":"104005","DOI":"10.1016\/j.mcn.2025.104005","volume":"133","author":"A Rekha","year":"2025","unstructured":"Rekha A, Afzal M, Babu MA, Menon SV, Nathiya D, Supriya S, Mishra SB, Gupta S, Goyal K, Rana M, Ali H, Imran M (2025) GSK-3beta dysregulation in aging: implications for Tau pathology and alzheimer\u2019s disease progression. Mol Cell Neurosci 133:104005. https:\/\/doi.org\/10.1016\/j.mcn.2025.104005","journal-title":"Mol Cell Neurosci"},{"issue":"1","key":"1650_CR117","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/toxsci\/kfy155","volume":"165","author":"Y Ren","year":"2018","unstructured":"Ren Y, Chen J, Wu X, Gui C, Mao K, Zou F, Li W (2018) Role of c-Abl-GSK3beta signaling in MPP+-Induced Autophagy-Lysosomal dysfunction. Toxicol Sci 165(1):232\u2013243. https:\/\/doi.org\/10.1093\/toxsci\/kfy155","journal-title":"Toxicol Sci"},{"issue":"2","key":"1650_CR118","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/0006-2952(94)90116-3","volume":"48","author":"A Rengasamy","year":"1994","unstructured":"Rengasamy A, Johns RA (1994) Effect of hydrogen peroxide and catalase on rat cerebellum nitric oxide synthase. Biochem Pharmacol 48(2):423\u2013425. https:\/\/doi.org\/10.1016\/0006-2952(94)90116-3","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"1650_CR119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.arcmed.2007.10.001","volume":"39","author":"LE Rojo","year":"2008","unstructured":"Rojo LE, Fernandez JA, Maccioni AA, Jimenez JM, Maccioni RB (2008) Neuroinflammation: implications for the pathogenesis and molecular diagnosis of alzheimer\u2019s disease. Arch Med Res 39(1):1\u201316. https:\/\/doi.org\/10.1016\/j.arcmed.2007.10.001","journal-title":"Arch Med Res"},{"issue":"6907","key":"1650_CR120","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1136\/bmj.307.6907.779","volume":"307","author":"M Rossor","year":"1993","unstructured":"Rossor M (1993) Alzheimer\u2019s disease. BMJ 307(6907):779\u2013782. https:\/\/doi.org\/10.1136\/bmj.307.6907.779","journal-title":"BMJ"},{"key":"1650_CR121","doi-asserted-by":"publisher","unstructured":"Saha S, Buttari B, Panieri E, Profumo E, Saso L (2020) An overview of Nrf2 signaling pathway and its role in inflammation. Molecules 25(22). https:\/\/doi.org\/10.3390\/molecules25225474","DOI":"10.3390\/molecules25225474"},{"issue":"1","key":"1650_CR122","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3233\/JAD-2011-102025","volume":"25","author":"SD Schlatterer","year":"2011","unstructured":"Schlatterer SD, Tremblay MA, Acker CM, Davies P (2011) Neuronal c-Abl overexpression leads to neuronal loss and neuroinflammation in the mouse forebrain. J Alzheimers Dis 25(1):119\u2013133. https:\/\/doi.org\/10.3233\/JAD-2011-102025","journal-title":"J Alzheimers Dis"},{"issue":"6","key":"1650_CR123","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1002\/jcb.21067","volume":"99","author":"SP Scott","year":"2006","unstructured":"Scott SP, Pandita TK (2006) The cellular control of DNA double-strand breaks. J Cell Biochem 99(6):1463\u20131475. https:\/\/doi.org\/10.1002\/jcb.21067","journal-title":"J Cell Biochem"},{"issue":"2","key":"1650_CR124","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/s0092-8674(00)81847-4","volume":"88","author":"R Scully","year":"1997","unstructured":"Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM (1997) Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88(2):265\u2013275. https:\/\/doi.org\/10.1016\/s0092-8674(00)81847-4","journal-title":"Cell"},{"issue":"1","key":"1650_CR125","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s40478-019-0723-5","volume":"7","author":"NM Shanbhag","year":"2019","unstructured":"Shanbhag NM, Evans MD, Mao W, Nana AL, Seeley WW, Adame A, Rissman RA, Masliah E, Mucke L (2019) Early neuronal accumulation of DNA double strand breaks in alzheimer\u2019s disease. Acta Neuropathol Commun 7(1):77. https:\/\/doi.org\/10.1186\/s40478-019-0723-5","journal-title":"Acta Neuropathol Commun"},{"issue":"2","key":"1650_CR126","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.bbrc.2009.03.020","volume":"382","author":"H Shimizu","year":"2009","unstructured":"Shimizu H, Popova M, Fleury F, Kobayashi M, Hayashi N, Sakane I, Kurumizaka H, Venkitaraman AR, Takahashi M, Yamamoto K (2009) c-ABL tyrosine kinase stabilizes RAD51 chromatin association. Biochem Biophys Res Commun 382(2):286\u2013291. https:\/\/doi.org\/10.1016\/j.bbrc.2009.03.020","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"1650_CR127","doi-asserted-by":"publisher","first-page":"e3000660","DOI":"10.1371\/journal.pbio.3000660","volume":"18","author":"S Sil","year":"2020","unstructured":"Sil S, Hu G, Liao K, Niu F, Callen S, Periyasamy P, Fox HS, Buch S (2020) HIV-1 Tat-mediated astrocytic amyloidosis involves the HIF-1alpha\/lncRNA BACE1-AS axis. PLoS Biol 18(5):e3000660. https:\/\/doi.org\/10.1371\/journal.pbio.3000660","journal-title":"PLoS Biol"},{"issue":"6","key":"1650_CR128","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.14336\/AD.2021.0406","volume":"12","author":"S Sil","year":"2021","unstructured":"Sil S, Singh S, Chemparathy DT, Chivero ET, Gordon L, Buch S (2021) Astrocytes & astrocyte derived extracellular vesicles in morphine induced amyloidopathy: implications for cognitive deficits in opiate abusers. Aging Dis 12(6):1389\u20131408. https:\/\/doi.org\/10.14336\/AD.2021.0406","journal-title":"Aging Dis"},{"issue":"9","key":"1650_CR129","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/s0891-5849(02)01021-3","volume":"33","author":"MA Smith","year":"2002","unstructured":"Smith MA, Casadesus G, Joseph JA, Perry G (2002a) Amyloid-beta and Tau serve antioxidant functions in the aging and alzheimer brain. Free Radic Biol Med 33(9):1194\u20131199. https:\/\/doi.org\/10.1016\/s0891-5849(02)01021-3","journal-title":"Free Radic Biol Med"},{"issue":"11","key":"1650_CR130","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/s0891-5849(02)00793-1","volume":"32","author":"MA Smith","year":"2002","unstructured":"Smith MA, Perry G, Pryor WA (2002b) Causes and consequences of oxidative stress in alzheimer\u2019s disease. Free Radic Biol Med 32(11):1049. https:\/\/doi.org\/10.1016\/s0891-5849(02)00793-1","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"1650_CR131","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/s0896-6273(03)00367-2","volume":"39","author":"T Soucek","year":"2003","unstructured":"Soucek T, Cumming R, Dargusch R, Maher P, Schubert D (2003) The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide. Neuron 39(1):43\u201356. https:\/\/doi.org\/10.1016\/s0896-6273(03)00367-2","journal-title":"Neuron"},{"key":"1650_CR132","doi-asserted-by":"publisher","unstructured":"Srivastava A, Renna HA, Johnson M, Sheehan K, Ahmed S, Palaia T, Pinkhasov A, Gomolin IH, Wisniewski T, De Leon J, Reiss AB (2024) Nilotinib as a Prospective Treatment for Alzheimer\u2019s Disease: Effect on Proteins Involved in Neurodegeneration and Neuronal Homeostasis. Life (Basel) 14(10). https:\/\/doi.org\/10.3390\/life14101241","DOI":"10.3390\/life14101241"},{"issue":"5","key":"1650_CR134","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/nn.3356","volume":"16","author":"E Suberbielle","year":"2013","unstructured":"Suberbielle E, Sanchez PE, Kravitz AV, Wang X, Ho K, Eilertson K, Devidze N, Kreitzer AC, Mucke L (2013) Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-beta. Nat Neurosci 16(5):613\u2013621. https:\/\/doi.org\/10.1038\/nn.3356","journal-title":"Nat Neurosci"},{"key":"1650_CR133","doi-asserted-by":"publisher","first-page":"8897","DOI":"10.1038\/ncomms9897","volume":"6","author":"E Suberbielle","year":"2015","unstructured":"Suberbielle E, Djukic B, Evans M, Kim DH, Taneja P, Wang X, Finucane M, Knox J, Ho K, Devidze N, Masliah E, Mucke L (2015) DNA repair factor BRCA1 depletion occurs in alzheimer brains and impairs cognitive function in mice. Nat Commun 6:8897. https:\/\/doi.org\/10.1038\/ncomms9897","journal-title":"Nat Commun"},{"issue":"41","key":"1650_CR135","doi-asserted-by":"publisher","first-page":"E6045","DOI":"10.1073\/pnas.1604807113","volume":"113","author":"S Subramanyam","year":"2016","unstructured":"Subramanyam S, Ismail M, Bhattacharya I, Spies M (2016) Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics. Proc Natl Acad Sci U S A 113(41):E6045\u2013E6054. https:\/\/doi.org\/10.1073\/pnas.1604807113","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"23","key":"1650_CR136","doi-asserted-by":"publisher","first-page":"17237","DOI":"10.1074\/jbc.C000099200","volume":"275","author":"X Sun","year":"2000","unstructured":"Sun X, Majumder P, Shioya H, Wu F, Kumar S, Weichselbaum R, Kharbanda S, Kufe D (2000a) Activation of the cytoplasmic c-Abl tyrosine kinase by reactive oxygen species. J Biol Chem 275(23):17237\u201317240. https:\/\/doi.org\/10.1074\/jbc.C000099200","journal-title":"J Biol Chem"},{"issue":"11","key":"1650_CR137","doi-asserted-by":"publisher","first-page":"7470","DOI":"10.1074\/jbc.275.11.7470","volume":"275","author":"X Sun","year":"2000","unstructured":"Sun X, Wu F, Datta R, Kharbanda S, Kufe D (2000b) Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. J Biol Chem 275(11):7470\u20137473. https:\/\/doi.org\/10.1074\/jbc.275.11.7470","journal-title":"J Biol Chem"},{"key":"1650_CR138","doi-asserted-by":"publisher","unstructured":"Surguchov A, Emamzadeh FN, Titova M, Surguchev AA (2023) Controversial properties of amyloidogenic proteins and peptides: new data in the COVID era. Biomedicines 11(4). https:\/\/doi.org\/10.3390\/biomedicines11041215","DOI":"10.3390\/biomedicines11041215"},{"key":"1650_CR139","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1146\/annurev-genet-110410-132435","volume":"45","author":"LS Symington","year":"2011","unstructured":"Symington LS, Gautier J (2011) Double-strand break end resection and repair pathway choice. Annu Rev Genet 45:247\u2013271. https:\/\/doi.org\/10.1146\/annurev-genet-110410-132435","journal-title":"Annu Rev Genet"},{"issue":"13","key":"1650_CR140","doi-asserted-by":"publisher","first-page":"7457","DOI":"10.1073\/pnas.95.13.7457","volume":"95","author":"S Taagepera","year":"1998","unstructured":"Taagepera S, McDonald D, Loeb JE, Whitaker LL, McElroy AK, Wang JY, Hope TJ (1998) Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proc Natl Acad Sci U S A 95(13):7457\u20137462. https:\/\/doi.org\/10.1073\/pnas.95.13.7457","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"1650_CR141","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","volume":"11","author":"JM Tarasoff-Conway","year":"2015","unstructured":"Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, Menard J, Zetterberg H, Wisniewski T, de Leon MJ (2015) Clearance systems in the brain-implications for alzheimer disease. Nat Rev Neurol 11(8):457\u2013470. https:\/\/doi.org\/10.1038\/nrneurol.2015.119","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"1650_CR142","doi-asserted-by":"publisher","first-page":"721","DOI":"10.3233\/JAD-2010-1271","volume":"19","author":"MA Tremblay","year":"2010","unstructured":"Tremblay MA, Acker CM, Davies P (2010) Tau phosphorylated at tyrosine 394 is found in alzheimer\u2019s disease tangles and can be a product of the Abl-related kinase, Arg. J Alzheimers Dis 19(2):721\u2013733. https:\/\/doi.org\/10.3233\/JAD-2010-1271","journal-title":"J Alzheimers Dis"},{"key":"1650_CR143","doi-asserted-by":"publisher","first-page":"120111","DOI":"10.1016\/j.lfs.2021.120111","volume":"291","author":"AV Ulasov","year":"2022","unstructured":"Ulasov AV, Rosenkranz AA, Georgiev GP, Sobolev AS (2022) Nrf2\/Keap1\/ARE signaling: towards specific regulation. Life Sci 291:120111. https:\/\/doi.org\/10.1016\/j.lfs.2021.120111","journal-title":"Life Sci"},{"issue":"3","key":"1650_CR145","doi-asserted-by":"publisher","first-page":"e92309","DOI":"10.1371\/journal.pone.0092309","volume":"9","author":"LM Vargas","year":"2014","unstructured":"Vargas LM, Leal N, Estrada LD, Gonzalez A, Serrano F, Araya K, Gysling K, Inestrosa NC, Pasquale EB, Alvarez AR (2014) EphA4 activation of c-Abl mediates synaptic loss and LTP Blockade caused by amyloid-beta oligomers. PLoS ONE 9(3):e92309. https:\/\/doi.org\/10.1371\/journal.pone.0092309","journal-title":"PLoS ONE"},{"issue":"4 Pt A","key":"1650_CR144","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.bbadis.2018.01.023","volume":"1864","author":"LM Vargas","year":"2018","unstructured":"Vargas LM, Cerpa W, Munoz FJ, Zanlungo S, Alvarez AR (2018) Amyloid-beta oligomers synaptotoxicity: the emerging role of EphA4\/c-Abl signaling in alzheimer\u2019s disease. Biochim Biophys Acta Mol Basis Dis 1864(4 Pt A):1148\u20131159. https:\/\/doi.org\/10.1016\/j.bbadis.2018.01.023","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"5440","key":"1650_CR146","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1126\/science.286.5440.735","volume":"286","author":"R Vassar","year":"1999","unstructured":"Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M (1999) Beta-secretase cleavage of alzheimer\u2019s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286(5440):735\u2013741. https:\/\/doi.org\/10.1126\/science.286.5440.735","journal-title":"Science"},{"issue":"7","key":"1650_CR147","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1128\/MCB.01454-13","volume":"34","author":"JY Wang","year":"2014","unstructured":"Wang JY (2014) The capable ABL: what is its biological function? Mol Cell Biol 34(7):1188\u20131197. https:\/\/doi.org\/10.1128\/MCB.01454-13","journal-title":"Mol Cell Biol"},{"issue":"3","key":"1650_CR148","doi-asserted-by":"publisher","first-page":"949","DOI":"10.3233\/JAD-201448","volume":"80","author":"YY Wang","year":"2021","unstructured":"Wang YY, Huang ZT, Yuan MH, Jing F, Cai RL, Zou Q, Pu YS, Wang SY, Chen F, Yi WM, Zhang HJ, Cai ZY (2021) Role of hypoxia inducible Factor-1alpha in alzheimer\u2019s disease. J Alzheimers Dis 80(3):949\u2013961. https:\/\/doi.org\/10.3233\/JAD-201448","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"1650_CR149","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1074\/jbc.M117.808402","volume":"293","author":"S Welty","year":"2018","unstructured":"Welty S, Teng Y, Liang Z, Zhao W, Sanders LH, Greenamyre JT, Rubio ME, Thathiah A, Kodali R, Wetzel R, Levine AS, Lan L (2018) RAD52 is required for RNA-templated recombination repair in post-mitotic neurons. J Biol Chem 293(4):1353\u20131362. https:\/\/doi.org\/10.1074\/jbc.M117.808402","journal-title":"J Biol Chem"},{"issue":"19","key":"1650_CR150","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1101\/gad.11.19.2456","volume":"11","author":"ST Wen","year":"1997","unstructured":"Wen ST, Van Etten RA (1997) The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity. Genes Dev 11(19):2456\u20132467. https:\/\/doi.org\/10.1101\/gad.11.19.2456","journal-title":"Genes Dev"},{"issue":"7","key":"1650_CR151","first-page":"609","volume":"378","author":"RH Wenger","year":"1997","unstructured":"Wenger RH, Gassmann M (1997) Oxygen(es) and the hypoxia-inducible factor-1. Biol Chem 378(7):609\u2013616","journal-title":"Biol Chem"},{"issue":"10","key":"1650_CR152","doi-asserted-by":"publisher","first-page":"5486","DOI":"10.1073\/pnas.97.10.5486","volume":"97","author":"YE Whang","year":"2000","unstructured":"Whang YE, Tran C, Henderson C, Syljuasen RG, Rozengurt N, McBride WH, Sawyers CL (2000) c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency. Proc Natl Acad Sci U S A 97(10):5486\u20135491. https:\/\/doi.org\/10.1073\/pnas.97.10.5486","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"1650_CR153","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1042\/EBC20200007","volume":"64","author":"Y Xu","year":"2020","unstructured":"Xu Y, Xu D (2020) Repair pathway choice for double-strand breaks. Essays Biochem 64(5):765\u2013777. https:\/\/doi.org\/10.1042\/EBC20200007","journal-title":"Essays Biochem"},{"issue":"1","key":"1650_CR154","doi-asserted-by":"publisher","first-page":"5600","DOI":"10.1038\/s41598-018-23644-4","volume":"8","author":"H Yu","year":"2018","unstructured":"Yu H, Harrison FE, Xia F (2018) Altered DNA repair; an early pathogenic pathway in alzheimer\u2019s disease and obesity. Sci Rep 8(1):5600. https:\/\/doi.org\/10.1038\/s41598-018-23644-4","journal-title":"Sci Rep"},{"issue":"7","key":"1650_CR155","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1074\/jbc.273.7.3799","volume":"273","author":"ZM Yuan","year":"1998","unstructured":"Yuan ZM, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Kharbanda S, Wang R, Sung P, Shinohara A, Weichselbaum R, Kufe D (1998a) Regulation of Rad51 function by c-Abl in response to DNA damage. J Biol Chem 273(7):3799\u20133802. https:\/\/doi.org\/10.1074\/jbc.273.7.3799","journal-title":"J Biol Chem"},{"issue":"13","key":"1650_CR156","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1038\/sj.onc.1201698","volume":"16","author":"ZM Yuan","year":"1998","unstructured":"Yuan ZM, Utsugisawa T, Ishiko T, Nakada S, Huang Y, Kharbanda S, Weichselbaum R, Kufe D (1998b) Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation. Oncogene 16(13):1643\u20131648. https:\/\/doi.org\/10.1038\/sj.onc.1201698","journal-title":"Oncogene"},{"key":"1650_CR157","doi-asserted-by":"publisher","unstructured":"Yusifov R, Tippmann A, Staiger JF, Schluter OM, Lowel S (2021) Spine dynamics of PSD-95-deficient neurons in the visual cortex link silent synapses to structural cortical plasticity. Proc Natl Acad Sci U S A 118(10). https:\/\/doi.org\/10.1073\/pnas.2022701118","DOI":"10.1073\/pnas.2022701118"},{"issue":"23","key":"1650_CR158","doi-asserted-by":"publisher","first-page":"19787","DOI":"10.1074\/jbc.M100792200","volume":"276","author":"N Zambrano","year":"2001","unstructured":"Zambrano N, Bruni P, Minopoli G, Mosca R, Molino D, Russo C, Schettini G, Sudol M, Russo T (2001) The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene. J Biol Chem 276(23):19787\u201319792. https:\/\/doi.org\/10.1074\/jbc.M100792200","journal-title":"J Biol Chem"},{"issue":"1","key":"1650_CR159","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.apsb.2020.09.006","volume":"11","author":"H Zeng","year":"2021","unstructured":"Zeng H, Wang L, Zhang J, Pan T, Yu Y, Lu J, Zhou P, Yang H, Li P (2021) Activated PKB\/GSK-3beta synergizes with PKC-delta signaling in attenuating myocardial ischemia\/reperfusion injury via potentiation of NRF2 activity: therapeutic efficacy of dihydrotanshinone-I. Acta Pharm Sin B 11(1):71\u201388. https:\/\/doi.org\/10.1016\/j.apsb.2020.09.006","journal-title":"Acta Pharm Sin B"},{"issue":"10","key":"1650_CR160","doi-asserted-by":"publisher","first-page":"e3117","DOI":"10.1038\/cddis.2017.524","volume":"8","author":"L Zhou","year":"2017","unstructured":"Zhou L, Zhang Q, Zhang P, Sun L, Peng C, Yuan Z, Cheng J (2017) c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death. Cell Death Dis 8(10):e3117. https:\/\/doi.org\/10.1038\/cddis.2017.524","journal-title":"Cell Death Dis"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-025-01650-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10571-025-01650-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-025-01650-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:15:58Z","timestamp":1768342558000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10571-025-01650-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":160,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1650"],"URL":"https:\/\/doi.org\/10.1007\/s10571-025-01650-1","relation":{},"ISSN":["1573-6830"],"issn-type":[{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,12]]},"assertion":[{"value":"10 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}],"article-number":"13"}}