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The exacerbation of neuronal dysfunction in Alzheimer\u2019s disease is collectively contributed by dysregulation of astrocytic and microglial responses, invasion of peripheral immune cells, and chronic inflammation. A mechanistic understanding of molecular, cellular, and systems-level neuroimmune interactions in Alzheimer\u2019s disease is enabling rational, testable therapeutic strategies. We have tried to extensively address the molecular regulation of glial activation, inflammasome signaling, and immune cell invasion in Alzheimer\u2019s disease. This review highlights microglial metabolic reprogramming and lipid-metabolism dysregulation as major drivers of neuroinflammation. Existing and future therapeutic approaches to glial activation, immunometabolism, and inflammasome signaling are thoroughly reviewed, together with novel strategies involving stem cell-derived exosomes and peripheral immunity modulation. Artificial intelligence and machine learning technologies are the latest game-changing technologies in unraveling neuroimmune complexity, discovering biomarkers, simulating disease courses, and speeding up drug discovery. Integration of multi-omics information and AI-based predictive models is suggested as a critical strategy for the development of precision medicine strategies in neuroimmune therapeutics. Advancements in neuroimmune research, coupled with computational biology technological advancements, hold the promise to transform the therapeutic environment for Alzheimer\u2019s disease. Multitargeted, integrated interventions and data-driven strategies are set to overcome current limitations and advance closer to effective, personalized therapies.<\/jats:p>","DOI":"10.1007\/s10571-025-01651-0","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T17:33:34Z","timestamp":1766770414000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neuroimmune Dysregulation and AI-Driven Therapeutic Strategies in Alzheimer\u2019s Disease"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3252-7216","authenticated-orcid":false,"given":"Shampa","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0181-6197","authenticated-orcid":false,"given":"Rakesh","family":"Bhaskar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3849-5945","authenticated-orcid":false,"given":"Krishna Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3176-4268","authenticated-orcid":false,"given":"Samarth","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7818-0981","authenticated-orcid":false,"given":"Bhuvaneshwar","family":"Yarlagadda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-6932","authenticated-orcid":false,"given":"Jitendra Kumar","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0773-2661","authenticated-orcid":false,"given":"Sung Soo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"issue":"3","key":"1651_CR1","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/s41593-024-01847-5","volume":"28","author":"MA Abellanas","year":"2025","unstructured":"Abellanas MA, Purnapatre M, Burgaletto C, Schwartz M (2025) Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer\u2019s disease. 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