{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T19:50:30Z","timestamp":1788637830216,"version":"build-2803163510"},"reference-count":122,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":52,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Vellore Institute of Technology, Vellore"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Neurobiol"],"DOI":"10.1007\/s10571-026-01726-6","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:16:16Z","timestamp":1779171376000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gene Expression Analysis of Mitochondria-Associated Membrane (MAM)-Related Genes in ER Stress and Alzheimer\u2019s Disease"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6876-4554","authenticated-orcid":false,"given":"A. Anjana","family":"Mohan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6826-581X","authenticated-orcid":false,"given":"Priti","family":"Talwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"1726_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/GENES15050569","author":"M Aceves","year":"2024","unstructured":"Aceves M (2024) Role of neurocellular endoplasmic reticulum stress response in Alzheimer\u2019s disease and related dementias risk. Genes. https:\/\/doi.org\/10.3390\/GENES15050569","journal-title":"Genes"},{"issue":"8","key":"1726_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/S41419-022-05153-5","volume":"13","author":"A Ajoolabady","year":"2022","unstructured":"Ajoolabady A et al (2022) ER stress and UPR in Alzheimer\u2019s disease: mechanisms, pathogenesis, treatments. Cell Death Dis 13(8):706. https:\/\/doi.org\/10.1038\/S41419-022-05153-5","journal-title":"Cell Death Dis"},{"issue":"5","key":"1726_CR25","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.2353\/AJPATH.2009.090219","volume":"175","author":"E Area-Gomez","year":"2009","unstructured":"Area-Gomez E et al (2009) Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. Am J Pathol 175(5):1810. https:\/\/doi.org\/10.2353\/AJPATH.2009.090219","journal-title":"Am J Pathol"},{"issue":"24","key":"1726_CR26","doi-asserted-by":"publisher","first-page":"16917","DOI":"10.1074\/jbc.274.24.16917","volume":"274","author":"FA Arosa","year":"1999","unstructured":"Arosa FA et al (1999) Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules. J Biol Chem 274(24):16917\u201316922. https:\/\/doi.org\/10.1074\/jbc.274.24.16917","journal-title":"J Biol Chem"},{"issue":"1","key":"1726_CR27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M et al (2000) Gene ontology: tool for the unification of biology. Nature Genetics 2000 25:1 25(1):25\u201329. https:\/\/doi.org\/10.1038\/75556","journal-title":"Nature Genetics 2000 25:1"},{"issue":"6","key":"1726_CR28","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/J.NEURON.2019.12.015","volume":"105","author":"B Bai","year":"2020","unstructured":"Bai B et al (2020) Deep multilayer brain proteomics identifies molecular networks in Alzheimer\u2019s disease progression. Neuron 105(6):975. https:\/\/doi.org\/10.1016\/J.NEURON.2019.12.015","journal-title":"Neuron"},{"issue":"4","key":"1726_CR29","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1023\/B:APPT.0000031446.95532.AD","volume":"9","author":"Y Bando","year":"2004","unstructured":"Bando Y et al (2004) GRP94 reduces cell death in SH-SY5Y cells perturbated calcium homeostasis. Apoptosis 9(4):501\u2013508. https:\/\/doi.org\/10.1023\/B:APPT.0000031446.95532.AD","journal-title":"Apoptosis"},{"issue":"1","key":"1726_CR30","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1021\/PR025562R","volume":"2","author":"V Basrur","year":"2003","unstructured":"Basrur V et al (2003) Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. J Proteome Res 2(1):69\u201379. https:\/\/doi.org\/10.1021\/PR025562R","journal-title":"J Proteome Res"},{"key":"1726_CR118","doi-asserted-by":"publisher","unstructured":"Bilghe K et al (2025) \u2018EnhancedVolcano: publication-ready volcano plots with enhanced colouring and labeling\u2019. Available at: https:\/\/doi.org\/https:\/\/doi.org\/10.18129\/B9.bioc.EnhancedVolcano","DOI":"10.18129\/B9.bioc.EnhancedVolcano"},{"key":"1726_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2012.00263","volume":"3","author":"MK Brown","year":"2012","unstructured":"Brown MK, Naidoo N (2012) The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol 3:263. https:\/\/doi.org\/10.3389\/FPHYS.2012.00263","journal-title":"Front Physiol"},{"key":"1726_CR16","doi-asserted-by":"publisher","unstructured":"Buchanan H et al (2020) \u2018Synaptic Loss, ER Stress and Neuro-Inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer\u2019s Disease\u2019, Molecular Neurobiology, 57(8), p. 3258. Available at: https:\/\/doi.org\/10.1007\/S12035-020-01950-1","DOI":"10.1007\/S12035-020-01950-1"},{"key":"1726_CR2","doi-asserted-by":"publisher","unstructured":"Carbon S et al (2009) \u2018AmiGO: online access to ontology and annotation data\u2019, Bioinformatics, 25(2), pp. 288\u2013289. Available at: https:\/\/doi.org\/10.1093\/BIOINFORMATICS\/BTN615","DOI":"10.1093\/BIOINFORMATICS\/BTN615"},{"key":"1726_CR32","doi-asserted-by":"publisher","unstructured":"Chae S et al (2018) \u2018A mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles\u2019, Experimental & molecular medicine, 50(9). Available at: https:\/\/doi.org\/10.1038\/S12276-018-0154-6","DOI":"10.1038\/S12276-018-0154-6"},{"key":"1726_CR33","doi-asserted-by":"publisher","unstructured":"Chaudhari N et al (2014) \u2018A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress\u2019, Frontiers in Cellular Neuroscience, 8(JULY). Available at: https:\/\/doi.org\/10.3389\/FNCEL.2014.00213","DOI":"10.3389\/FNCEL.2014.00213"},{"key":"1726_CR4","doi-asserted-by":"publisher","unstructured":"Chen SF et al (2013) \u2018Caveolin-1 interacts with derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex\u2019, Journal of Biological Chemistry, 288(46), pp. 33462\u201333469. Available at: https:\/\/doi.org\/10.1074\/jbc.M113.521799","DOI":"10.1074\/jbc.M113.521799"},{"key":"1726_CR1","doi-asserted-by":"publisher","unstructured":"Chen W et al (2020) \u2018A comparison of methods accounting for batch effects in differential expression analysis of UMI count based single cell RNA sequencing\u2019, Computational and structural biotechnology journal, 18, pp. 861\u2013873. Available at: https:\/\/doi.org\/10.1016\/J.CSBJ.2020.03.026","DOI":"10.1016\/J.CSBJ.2020.03.026"},{"key":"1726_CR34","doi-asserted-by":"publisher","unstructured":"Chen W et al (2025) \u2018CERS6 promotes esophageal squamous cell carcinoma proliferation by increasing the stability of RPN1\u2019, Cell death discovery, 11(1). Available at: https:\/\/doi.org\/10.1038\/s41420-025-02727-y","DOI":"10.1038\/s41420-025-02727-y"},{"key":"1726_CR5","doi-asserted-by":"publisher","unstructured":"Chin CH et al (2014) \u2018cytoHubba: Identifying hub objects and sub-networks from complex interactome\u2019, BMC Systems Biology, 8(4), pp. 1\u20137. Available at: https:\/\/doi.org\/10.1186\/1752-0509-8-S4-S11\/TABLES\/4","DOI":"10.1186\/1752-0509-8-S4-S11\/TABLES\/4"},{"issue":"3","key":"1726_CR35","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/NCB1689","volume":"10","author":"JC Christianson","year":"2008","unstructured":"Christianson JC et al (2008) OS-9 and GRP94 deliver mutant \u03b11-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat Cell Biol 10(3):272. https:\/\/doi.org\/10.1038\/NCB1689","journal-title":"Nat Cell Biol"},{"key":"1726_CR119","doi-asserted-by":"crossref","unstructured":"Darwich NF et al (2020) \u2018Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau\u2019, Science, 370(6519). Available at: SUPPL_FILE\/AAY8826_DARWICH_REPRODUCIBILITY_CHECKLIST.PDF. http:\/\/SUPPL_FILE\/AAY8826_DARWICH_REPRODUCIBILITY_CHECKLIST.PDF","DOI":"10.1126\/science.aay8826"},{"issue":"14","key":"1726_CR36","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1093\/bioinformatics\/btm254","volume":"23","author":"S Davis","year":"2007","unstructured":"Davis S, Meltzer PS (2007) GEOquery: a bridge between the gene expression omnibus (GEO) and BioConductor. Bioinformatics 23(14):1846\u20131847. https:\/\/doi.org\/10.1093\/bioinformatics\/btm254","journal-title":"Bioinformatics"},{"issue":"2","key":"1726_CR38","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/S10495-006-0625-4\/METRICS","volume":"12","author":"F Delom","year":"2007","unstructured":"Delom F, Fessart D, Chevet E (2007) Regulation of calnexin sub-cellular localization modulates endoplasmic reticulum stress-induced apoptosis in MCF-7 cells. Apoptosis 12(2):293\u2013305. https:\/\/doi.org\/10.1007\/S10495-006-0625-4\/METRICS","journal-title":"Apoptosis"},{"issue":"4","key":"1726_CR37","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.3233\/JAD-160953","volume":"55","author":"D Del Prete","year":"2016","unstructured":"Del Prete D et al (2016) Localization and processing of the amyloid-\u03b2 protein precursor in mitochondria-associated membranes. J Alzheimers Dis 55(4):1549. https:\/\/doi.org\/10.3233\/JAD-160953","journal-title":"J Alzheimers Dis"},{"key":"1726_CR39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI.INSIGHT.188904","author":"S Ding","year":"2025","unstructured":"Ding S et al (2025) AI662270\/GRP94 axis couples the unfolded protein response to mitochondrial dynamics during acute myocardial infarction. JCI Insight. https:\/\/doi.org\/10.1172\/JCI.INSIGHT.188904","journal-title":"JCI Insight"},{"issue":"21","key":"1726_CR40","doi-asserted-by":"publisher","first-page":"3424","DOI":"10.1016\/J.FEBSLET.2011.09.032","volume":"585","author":"PJ Dolan","year":"2011","unstructured":"Dolan PJ et al (2011) Decreases in valosin-containing protein result in increased levels of tau phosphorylated at Ser 262\/356. FEBS Lett 585(21):3424\u20133429. https:\/\/doi.org\/10.1016\/J.FEBSLET.2011.09.032","journal-title":"FEBS Lett"},{"issue":"5","key":"1726_CR41","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1083\/JCB.201005144","volume":"190","author":"PM Douglas","year":"2010","unstructured":"Douglas PM, Dillin A (2010) Protein homeostasis and aging in neurodegeneration. J Cell Biol 190(5):719. https:\/\/doi.org\/10.1083\/JCB.201005144","journal-title":"J Cell Biol"},{"key":"1726_CR120","doi-asserted-by":"publisher","unstructured":"Dunning M, Lynch A, Eldridge M (2017) \u2018Illumina HumanHT12v4 annotation data (chip illuminaHumanv4)\u2019. Available at: https:\/\/doi.org\/https:\/\/doi.org\/10.18129\/B9.bioc.illuminaHumanv4.db","DOI":"10.18129\/B9.bioc.illuminaHumanv4.db"},{"issue":"3","key":"1726_CR42","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/S00401-017-1694-X","volume":"134","author":"C Duran-Aniotz","year":"2017","unstructured":"Duran-Aniotz C et al (2017) IRE1 signaling exacerbates Alzheimer\u2019s disease pathogenesis. Acta Neuropathologica 2017 134:3 134(3):489\u2013506. https:\/\/doi.org\/10.1007\/S00401-017-1694-X","journal-title":"Acta Neuropathologica 2017 134:3"},{"issue":"1","key":"1726_CR43","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/NAR\/30.1.207","volume":"30","author":"R Edgar","year":"2002","unstructured":"Edgar R, Domrachev M, Lash AE (2002) Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30(1):207\u2013210. https:\/\/doi.org\/10.1093\/NAR\/30.1.207","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"1726_CR45","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/J.SEMCDB.2010.03.004","volume":"21","author":"D Eletto","year":"2010","unstructured":"Eletto D, Dersh D, Argon Y (2010) GRP94 in ER quality control and stress responses. Semin Cell Dev Biol 21(5):479\u2013485. https:\/\/doi.org\/10.1016\/J.SEMCDB.2010.03.004","journal-title":"Semin Cell Dev Biol"},{"issue":"13","key":"1726_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26136349","volume":"26","author":"S El Hazzouri","year":"2025","unstructured":"El Hazzouri S et al (2025) FVIII Trafficking Dynamics Across Subcellular Organelles Using CRISPR\/Cas9 Specific Gene Knockouts. Int J Mol Sci 26(13):6349. https:\/\/doi.org\/10.3390\/ijms26136349","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1726_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23041939","volume":"23","author":"V Ferrari","year":"2022","unstructured":"Ferrari V et al (2022) Valosin Containing Protein (VCP): A Multistep Regulator of Autophagy. Int J Mol Sci 23(4):1939. https:\/\/doi.org\/10.3390\/ijms23041939","journal-title":"Int J Mol Sci"},{"key":"1726_CR47","doi-asserted-by":"publisher","DOI":"10.15252\/EMBJ.2020107240","author":"I Fregno","year":"2021","unstructured":"Fregno I (2021) N-glycan processing selects ERAD\u2010resistant misfolded proteins for ER\u2010to\u2010lysosome\u2010associated degradation. EMBO J. https:\/\/doi.org\/10.15252\/EMBJ.2020107240","journal-title":"EMBO J"},{"issue":"17","key":"1726_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/IJMS21176127","volume":"21","author":"R Ghemrawi","year":"2020","unstructured":"Ghemrawi R, Khair M (2020) Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases. Int J Mol Sci 21(17):1\u201325. https:\/\/doi.org\/10.3390\/IJMS21176127","journal-title":"Int J Mol Sci"},{"key":"1726_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/FCELL.2022.918691","volume":"10","author":"B Gottschalk","year":"2022","unstructured":"Gottschalk B et al (2022) MFN2 mediates ER-mitochondrial coupling during ER stress through specialized stable contact sites. Front Cell Dev Biol 10:918691. https:\/\/doi.org\/10.3389\/FCELL.2022.918691","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"1726_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s43586-022-00184-w","volume":"2","author":"M Greenacre","year":"2022","unstructured":"Greenacre M et al (2022) Principal component analysis. Nature Reviews Methods Primers 2022 2:1 2(1):1\u201321. https:\/\/doi.org\/10.1038\/s43586-022-00184-w","journal-title":"Nature Reviews Methods Primers 2022 2:1"},{"issue":"3","key":"1726_CR51","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.cell.2007.08.036","volume":"131","author":"T Hayashi","year":"2007","unstructured":"Hayashi T, Su TP (2007) Sigma-1 receptor chaperones at the ER- mitochondrion interface regulate Ca2\u2009+\u2009signaling and cell survival. Cell 131(3):596\u2013610. https:\/\/doi.org\/10.1016\/j.cell.2007.08.036","journal-title":"Cell"},{"key":"1726_CR10","doi-asserted-by":"publisher","unstructured":"Heberle H et al (2015) \u2018InteractiVenn: A web-based tool for the analysis of sets through Venn diagrams\u2019, BMC Bioinformatics, 16(1), pp. 1\u20137. Available at: https:\/\/doi.org\/10.1186\/S12859-015-0611-3\/FIGURES\/4","DOI":"10.1186\/S12859-015-0611-3\/FIGURES\/4"},{"issue":"19","key":"1726_CR52","doi-asserted-by":"publisher","first-page":"7916","DOI":"10.1073\/PNAS.1300677110","volume":"110","author":"L Hedskog","year":"2013","unstructured":"Hedskog L et al (2013) Modulation of the endoplasmic reticulum\u2013mitochondria interface in Alzheimer\u2019s disease and related models. Proc Natl Acad Sci U S A 110(19):7916\u20137921. https:\/\/doi.org\/10.1073\/PNAS.1300677110","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"1726_CR53","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/S41580-020-0250-Z","volume":"21","author":"C Hetz","year":"2020","unstructured":"Hetz C, Zhang K, Kaufman RJ (2020) Mechanisms, regulation and functions of the unfolded protein response. Nat Rev Mol Cell Biol 21(8):421. https:\/\/doi.org\/10.1038\/S41580-020-0250-Z","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"1726_CR54","doi-asserted-by":"publisher","first-page":"85","DOI":"10.2108\/ZSJ.28.85","volume":"28","author":"A Higashino","year":"2011","unstructured":"Higashino A et al (2011) Detection of elevated antibody against calreticulin by ELISA in aged Cynomolgus monkey plasma. doi: 10.2108\/zsj.28.85 28(2):85\u201389. https:\/\/doi.org\/10.2108\/ZSJ.28.85","journal-title":"doi: 10.2108\/zsj.28.85"},{"issue":"4","key":"1726_CR55","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/S41589-020-00726-X","volume":"17","author":"SM Hill","year":"2021","unstructured":"Hill SM et al (2021) VCP\/p97 regulates Beclin-1-dependent autophagy initiation. Nat Chem Biol 17(4):448\u2013455. https:\/\/doi.org\/10.1038\/S41589-020-00726-X","journal-title":"Nat Chem Biol"},{"issue":"1","key":"1726_CR56","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1083\/JCB.152.1.127","volume":"152","author":"JM Holaska","year":"2001","unstructured":"Holaska JM et al (2001) Calreticulin is a receptor for nuclear export. J Cell Biol 152(1):127\u2013140. https:\/\/doi.org\/10.1083\/JCB.152.1.127","journal-title":"J Cell Biol"},{"issue":"4","key":"1726_CR57","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.2353\/ajpath.2009.080814","volume":"174","author":"JJM Hoozemans","year":"2009","unstructured":"Hoozemans JJM et al (2009) The unfolded protein response is activated in pretangle neurons in Alzheimer\u2019s disease hippocampus. Am J Pathol 174(4):1241\u20131251. https:\/\/doi.org\/10.2353\/ajpath.2009.080814","journal-title":"Am J Pathol"},{"issue":"3","key":"1726_CR58","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0117963","volume":"10","author":"SM Horner","year":"2015","unstructured":"Horner SM et al (2015) Proteomic analysis of mitochondrial-associated ER membranes (MAM) during RNA virus infection reveals dynamic changes in protein and organelle trafficking. PLoS One 10(3):e0117963. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0117963","journal-title":"PLoS One"},{"issue":"1","key":"1726_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S12017-024-08822-0","volume":"27","author":"C Huang","year":"2025","unstructured":"Huang C et al (2025) From genes to metabolites: HSP90B1\u2019s role in Alzheimer\u2019s disease and potential for therapeutic intervention. Neuromol Med 27(1):1\u201318. https:\/\/doi.org\/10.1007\/S12017-024-08822-0","journal-title":"Neuromol Med"},{"key":"1726_CR60","doi-asserted-by":"publisher","DOI":"10.1152\/AJPHEART.00909.2013","author":"BG Hughes","year":"2014","unstructured":"Hughes BG (2014) MMP-2 is localized to the mitochondria-associated membrane of the heart. Am J Physiol Heart Circ Physiol. https:\/\/doi.org\/10.1152\/AJPHEART.00909.2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"1726_CR61","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/SJ.EMBOJ.7600052","volume":"23","author":"P Iakova","year":"2004","unstructured":"Iakova P et al (2004) Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. EMBO J 23(2):406\u2013417. https:\/\/doi.org\/10.1038\/SJ.EMBOJ.7600052","journal-title":"EMBO J"},{"issue":"2\u20133","key":"1726_CR62","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0925-4439(01)00049-7","volume":"1536","author":"K Imaizumi","year":"2001","unstructured":"Imaizumi K et al (2001) The unfolded protein response and Alzheimer\u2019s disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1536(2\u20133):85\u201396. https:\/\/doi.org\/10.1016\/S0925-4439(01)00049-7","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"issue":"49","key":"1726_CR63","doi-asserted-by":"publisher","first-page":"51376","DOI":"10.1074\/jbc.M406683200","volume":"279","author":"S Ishigaki","year":"2004","unstructured":"Ishigaki S et al (2004) Physical and functional interaction between dorfin and valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders. J Biol Chem 279(49):51376\u201351385. https:\/\/doi.org\/10.1074\/jbc.M406683200","journal-title":"J Biol Chem"},{"issue":"9","key":"1726_CR64","doi-asserted-by":"publisher","first-page":"871","DOI":"10.2174\/1871527319666201209111006","volume":"20","author":"R Jakhmola-Mani","year":"2021","unstructured":"Jakhmola-Mani R, Islam A, Katare DP (2021) Liver-brain axis in sporadic Alzheimer\u2019s disease: role of ten signature genes in a mouse model. CNS & Neurological Disorders - Drug Targets 20(9):871\u2013885. https:\/\/doi.org\/10.2174\/1871527319666201209111006","journal-title":"CNS & Neurological Disorders - Drug Targets"},{"key":"1726_CR3","doi-asserted-by":"publisher","unstructured":"Johnson RJ et al (2001) \u2018Calreticulin functions as a molecular chaperone for the \u03b2-amyloid precursor protein\u2019, Neurobiology of Aging, 22(3), pp. 387\u2013395. Available at: https:\/\/doi.org\/10.1016\/S0197-4580(00)00247-5","DOI":"10.1016\/S0197-4580(00)00247-5"},{"issue":"2","key":"1726_CR65","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/S41375-022-01781-0","volume":"37","author":"JS Jutzi","year":"2022","unstructured":"Jutzi JS et al (2022) CALR-mutated cells are vulnerable to combined inhibition of the proteasome and the endoplasmic reticulum stress response. Leukemia 37(2):359. https:\/\/doi.org\/10.1038\/S41375-022-01781-0","journal-title":"Leukemia"},{"issue":"1","key":"1726_CR66","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/NAR\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27\u201330. https:\/\/doi.org\/10.1093\/NAR\/28.1.27","journal-title":"Nucleic Acids Res"},{"key":"1726_CR67","doi-asserted-by":"crossref","unstructured":"Katayama T et al (1999) \u2018Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response\u2019, Nature Cell Biology, 1(8), pp. 479\u2013485. Available at:","DOI":"10.1038\/70265"},{"issue":"43","key":"1726_CR68","doi-asserted-by":"publisher","first-page":"37602","DOI":"10.1074\/jbc.M111.284794","volume":"286","author":"EJ Klemm","year":"2011","unstructured":"Klemm EJ, Spooner E, Ploegh HL (2011) Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control. J Biol Chem 286(43):37602\u201337614. https:\/\/doi.org\/10.1074\/jbc.M111.284794","journal-title":"J Biol Chem"},{"key":"1726_CR69","doi-asserted-by":"publisher","first-page":"214","DOI":"10.3389\/FMOLB.2020.00214\/FULL","volume":"7","author":"MB Koopman","year":"2020","unstructured":"Koopman MB, R\u00fcdiger SGD (2020) Alzheimer cells on their way to derailment show selective changes in protein quality control network. Front Mol Biosci 7:214. https:\/\/doi.org\/10.3389\/FMOLB.2020.00214\/FULL","journal-title":"Front Mol Biosci"},{"issue":"5","key":"1726_CR70","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1177\/10738584231162810","volume":"30","author":"M Kuijpers","year":"2024","unstructured":"Kuijpers M, Nguyen PT, Haucke V (2024) The endoplasmic reticulum and its contacts: emerging roles in axon development, neurotransmission, and degeneration. Neuroscientist 30(5):545\u2013559. https:\/\/doi.org\/10.1177\/10738584231162810","journal-title":"Neuroscientist"},{"key":"1726_CR9","doi-asserted-by":"publisher","unstructured":"Lai Y et al (2022) \u2018Identification of endoplasmic reticulum stress-associated genes and subtypes for prediction of Alzheimer\u2019s disease based on interpretable machine learning\u2019, Frontiers in Pharmacology, 13, p. 975774. Available at: https:\/\/doi.org\/10.3389\/FPHAR.2022.975774\/BIBTEX","DOI":"10.3389\/FPHAR.2022.975774\/BIBTEX"},{"issue":"1","key":"1726_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2105-9-559\/FIGURES\/4","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9(1):1\u201313. https:\/\/doi.org\/10.1186\/1471-2105-9-559\/FIGURES\/4","journal-title":"BMC Bioinformatics"},{"key":"1726_CR72","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0010489","author":"DY Lee","year":"2010","unstructured":"Lee DY et al (2010) Activation of PERK signaling attenuates A\u03b2-mediated ER stress. PLoS One. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0010489","journal-title":"PLoS One"},{"issue":"6","key":"1726_CR73","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/BIOINFORMATICS\/BTS034","volume":"28","author":"JT Leek","year":"2012","unstructured":"Leek JT et al (2012) The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics (Oxford, England) 28(6):882\u2013883. https:\/\/doi.org\/10.1093\/BIOINFORMATICS\/BTS034","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"12","key":"1726_CR75","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/BIOINFORMATICS\/BTR260","volume":"27","author":"A Liberzon","year":"2011","unstructured":"Liberzon A et al (2011) Molecular signatures database (MSigDB) 3.0. Bioinformatics 27(12):1739\u20131740. https:\/\/doi.org\/10.1093\/BIOINFORMATICS\/BTR260","journal-title":"Bioinformatics"},{"issue":"12","key":"1726_CR76","doi-asserted-by":"publisher","first-page":"21740","DOI":"10.3390\/IJMS151221740","volume":"15","author":"Q Lin","year":"2014","unstructured":"Lin Q, Cao Y, Gao J (2014) Serum calreticulin is a negative biomarker in patients with Alzheimer\u2019s disease. Int J Mol Sci 15(12):21740. https:\/\/doi.org\/10.3390\/IJMS151221740","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1726_CR77","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1182\/BLOOD-2008-03-143107","volume":"112","author":"B Liu","year":"2008","unstructured":"Liu B, Li Z (2008) Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell. Blood 112(4):1223. https:\/\/doi.org\/10.1182\/BLOOD-2008-03-143107","journal-title":"Blood"},{"key":"1726_CR13","unstructured":"Liu Y et al (2025) \u2018Mitochondria-Associated Endoplasmic Reticulum Membranes in Human Health and Diseases\u2019, MedComm, 6(7), p. e70259. Available at: JOURNAL:JOURNAL:26882663;WGROUP:STRING:PUBLICATION"},{"key":"1726_CR74","doi-asserted-by":"publisher","unstructured":"Li Y et al (2024) \u2018Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury\u2019, Journal of Translational Medicine, 22(1). Available at: https:\/\/doi.org\/10.1186\/S12967-024-05021-0","DOI":"10.1186\/S12967-024-05021-0"},{"issue":"12","key":"1726_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15(12):1\u201321. https:\/\/doi.org\/10.1186\/S13059-014-0550-8","journal-title":"Genome Biol"},{"issue":"2","key":"1726_CR79","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/EMBOJ.2011.384","volume":"31","author":"EM Lynes","year":"2012","unstructured":"Lynes EM et al (2012) Palmitoylated TMX and calnexin target to the mitochondria-associated membrane. EMBO J 31(2):457\u2013470. https:\/\/doi.org\/10.1038\/EMBOJ.2011.384","journal-title":"EMBO J"},{"key":"1726_CR15","doi-asserted-by":"publisher","unstructured":"Lynes EM et al (2013) \u2018Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2\u2009+\u2009signaling\u2019, Journal of Cell Science, 126(17), pp. 3893\u20133903. Available at: https:\/\/doi.org\/10.1242\/JCS.125856","DOI":"10.1242\/JCS.125856"},{"key":"1726_CR81","doi-asserted-by":"publisher","DOI":"10.1016\/J.CONB.2023.102684","volume":"79","author":"RW Mahley","year":"2023","unstructured":"Mahley RW (2023) Apolipoprotein E4 targets mitochondria and the mitochondria-associated membrane complex in neuropathology, including Alzheimer\u2019s disease. Curr Opin Neurobiol 79:102684. https:\/\/doi.org\/10.1016\/J.CONB.2023.102684","journal-title":"Curr Opin Neurobiol"},{"issue":"1","key":"1726_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-02213-1","volume":"7","author":"JH Ma","year":"2017","unstructured":"Ma JH et al (2017) Comparative proteomic analysis of the mitochondria-associated ER membrane (MAM) in a long-term type 2 diabetic rodent model. Sci Rep 7(1):1\u201317. https:\/\/doi.org\/10.1038\/s41598-017-02213-1","journal-title":"Sci Rep"},{"key":"1726_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/J.BCP.2022.115011","volume":"199","author":"H Mao","year":"2022","unstructured":"Mao H et al (2022) Potential role of mitochondria-associated endoplasmic reticulum membrane proteins in diseases. Biochem Pharmacol 199:115011. https:\/\/doi.org\/10.1016\/J.BCP.2022.115011","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"1726_CR83","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/J.BBAMCR.2011.10.013","volume":"1823","author":"M Marzec","year":"2012","unstructured":"Marzec M, Eletto D, Argon Y (2012) GRP94: an HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1823(3):774\u2013787. https:\/\/doi.org\/10.1016\/J.BBAMCR.2011.10.013","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"},{"issue":"3","key":"1726_CR84","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1021\/ACS.JPROTEOME.9B00004","volume":"18","author":"J McKetney","year":"2019","unstructured":"McKetney J et al (2019) Proteomic atlas of the human brain in Alzheimer\u2019s disease. J Proteome Res 18(3):1380. https:\/\/doi.org\/10.1021\/ACS.JPROTEOME.9B00004","journal-title":"J Proteome Res"},{"issue":"1","key":"1726_CR85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S11658-025-00714-W","volume":"30","author":"AA Mohan","year":"2025","unstructured":"Mohan AA, Talwar P (2025) MAM kinases: physiological roles, related diseases, and therapeutic perspectives\u2014a systematic review. Cellular & Molecular Biology Letters 2025 30:1 30(1):1\u201340. https:\/\/doi.org\/10.1186\/S11658-025-00714-W","journal-title":"Cellular & Molecular Biology Letters 2025 30:1"},{"key":"1726_CR7","doi-asserted-by":"publisher","unstructured":"Mosbech A et al (2012) \u2018DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks\u2019, Nature structural & molecular biology, 19(11), pp. 1084\u20131092. Available at: https:\/\/doi.org\/10.1038\/NSMB.2395","DOI":"10.1038\/NSMB.2395"},{"issue":"17","key":"1726_CR86","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1038\/EMBOJ.2013.168","volume":"32","author":"JP Mu\u00f1oz","year":"2013","unstructured":"Mu\u00f1oz JP et al (2013) Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J 32(17):2348. https:\/\/doi.org\/10.1038\/EMBOJ.2013.168","journal-title":"EMBO J"},{"issue":"4","key":"1726_CR87","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1021\/PR401202D","volume":"13","author":"S Musunuri","year":"2014","unstructured":"Musunuri S et al (2014) Quantification of the brain proteome in Alzheimer\u2019s disease using multiplexed mass spectrometry. J Proteome Res 13(4):2056\u20132068. https:\/\/doi.org\/10.1021\/PR401202D","journal-title":"J Proteome Res"},{"key":"1726_CR122","doi-asserted-by":"publisher","unstructured":"Myhill, N. et al. (2008) The subcellular distribution of calnexin is mediated by PACS-2\u2019, Molecular Biology of the Cell,19(7), pp. 2777\u20132788. https:\/\/doi.org\/10.1091\/MBC.E07-10-0995\/ASSET\/IMAGES\/LARGE\/ZMK0070885860006.JPEG","DOI":"10.1091\/MBC.E07-10-0995\/ASSET\/IMAGES\/LARGE\/ZMK0070885860006.JPEG"},{"key":"1726_CR17","doi-asserted-by":"publisher","unstructured":"Nishitsuji K et al (2009) \u2018The E693\u2206 mutation in amyloid precursor protein increases intracellular accumulation of amyloid \u03b2 oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells\u2019, American Journal of Pathology, 174(3), pp. 957\u2013969. Available at: https:\/\/doi.org\/10.2353\/AJPATH.2009.080480\/ASSET\/2544FECD-B67E-4A32-874B-11D13B85297B\/MAIN.ASSETS\/GR10.JPG","DOI":"10.2353\/AJPATH.2009.080480\/ASSET\/2544FECD-B67E-4A32-874B-11D13B85297B\/MAIN.ASSETS\/GR10.JPG"},{"issue":"1","key":"1726_CR88","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1080\/19585969.2026.2622722","volume":"28","author":"J Peng","year":"2026","unstructured":"Peng J et al (2026) Current potential biomarkers for Alzheimer\u2019s disease, Parkinson\u2019s disease and amyotrophic lateral sclerosis: review of literature. Dialogues Clin Neurosci 28(1):17\u201339. https:\/\/doi.org\/10.1080\/19585969.2026.2622722","journal-title":"Dialogues Clin Neurosci"},{"issue":"3","key":"1726_CR89","doi-asserted-by":"publisher","first-page":"691","DOI":"10.3233\/JAD-181113","volume":"70","author":"IS Piras","year":"2019","unstructured":"Piras IS et al (2019) Transcriptome changes in the Alzheimer\u2019s disease middle temporal gyrus: importance of RNA metabolism and mitochondria-associated membrane genes. J Alzheimers Dis 70(3):691\u2013713. https:\/\/doi.org\/10.3233\/JAD-181113","journal-title":"J Alzheimers Dis"},{"key":"1726_CR90","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/J.JPROT.2012.12.018","volume":"79","author":"CN Poston","year":"2013","unstructured":"Poston CN, Krishnan SC, Bazemore-Walker CR (2013) In-depth proteomic analysis of mammalian mitochondria-associated membranes (MAM). J Proteomics 79:219\u2013230. https:\/\/doi.org\/10.1016\/J.JPROT.2012.12.018","journal-title":"J Proteomics"},{"issue":"D1","key":"1726_CR91","doi-asserted-by":"publisher","first-page":"D1541","DOI":"10.1093\/NAR\/GKAA1011","volume":"49","author":"S Rath","year":"2021","unstructured":"Rath S et al (2021) MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations. Nucleic Acids Res 49(D1):D1541\u2013D1547. https:\/\/doi.org\/10.1093\/NAR\/GKAA1011","journal-title":"Nucleic Acids Res"},{"key":"1726_CR92","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2022.859686","volume":"13","author":"KM Reid","year":"2022","unstructured":"Reid KM et al (2022) Brain cells release calreticulin that attracts and activates microglia, and inhibits amyloid beta aggregation and neurotoxicity. Front Immunol 13:859686. https:\/\/doi.org\/10.3389\/FIMMU.2022.859686","journal-title":"Front Immunol"},{"issue":"7","key":"1726_CR93","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/NAR\/GKV007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME et al (2015) Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43(7):e47\u2013e47. https:\/\/doi.org\/10.1093\/NAR\/GKV007","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"1726_CR94","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1083\/JCB.149.6.1235","volume":"149","author":"HL Roderick","year":"2000","unstructured":"Roderick HL, Lechleiter JD, Camacho P (2000) Cytosolic phosphorylation of calnexin controls intracellular Ca2\u2009+\u2009oscillations via an interaction with Serca2b. J Cell Biol 149(6):1235. https:\/\/doi.org\/10.1083\/JCB.149.6.1235","journal-title":"J Cell Biol"},{"issue":"48","key":"1726_CR95","doi-asserted-by":"publisher","first-page":"18434","DOI":"10.1074\/jbc.RA118.005769","volume":"293","author":"KR Sadleir","year":"2018","unstructured":"Sadleir KR, Popovic J, Vassar R (2018) ER stress is not elevated in the 5XFAD mouse model of Alzheimer\u2019s disease. J Biol Chem 293(48):18434\u201318443. https:\/\/doi.org\/10.1074\/jbc.RA118.005769","journal-title":"J Biol Chem"},{"key":"1726_CR96","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-019-46843-Z","author":"S Salati","year":"2019","unstructured":"Salati S et al (2019) Calreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in K562 cells expressing CALR mutants. Sci Rep. https:\/\/doi.org\/10.1038\/S41598-019-46843-Z","journal-title":"Sci Rep"},{"key":"1726_CR11","doi-asserted-by":"publisher","unstructured":"Sala-Vila A et al (2016) \u2018Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice\u2019, Scientific Reports 2016 6:1, 6(1), pp. 1\u201310. Available at: https:\/\/doi.org\/10.1038\/srep27351","DOI":"10.1038\/srep27351"},{"issue":"3","key":"1726_CR97","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/S1097-2765(01)00318-5","volume":"8","author":"JD Schrag","year":"2001","unstructured":"Schrag JD et al (2001) The structure of calnexin, an ER chaperone involved in quality control of protein folding. Mol Cell 8(3):633\u2013644. https:\/\/doi.org\/10.1016\/S1097-2765(01)00318-5","journal-title":"Mol Cell"},{"key":"1726_CR6","doi-asserted-by":"publisher","unstructured":"Shannon P et al (2003) \u2018Cytoscape: A software Environment for integrated models of biomolecular interaction networks\u2019, Genome Research, 13(11), pp. 2498\u20132504. Available at: https:\/\/doi.org\/10.1101\/GR.1239303","DOI":"10.1101\/GR.1239303"},{"key":"1726_CR98","doi-asserted-by":"publisher","unstructured":"Shen H et al (2025) \u2018The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease\u2019, Autophagy, 21(5). Available at: https:\/\/doi.org\/10.1080\/15548627.2024.2447206","DOI":"10.1080\/15548627.2024.2447206"},{"key":"1726_CR12","doi-asserted-by":"publisher","unstructured":"Soejima N et al (2013) \u2018Intracellular Accumulation of Toxic Turn Amyloid-\u03b2 is Associated with Endoplasmic Reticulum Stress in Alzheimer\u2019s Disease\u2019, Current Alzheimer Research, 10(1), pp. 11\u201320. Available at: https:\/\/doi.org\/10.2174\/1567205011310010003","DOI":"10.2174\/1567205011310010003"},{"key":"1726_CR8","doi-asserted-by":"publisher","unstructured":"Son SJ et al (2023) \u2018Ex vivo identification of transcriptional regulation landscape and potential therapeutic targets against ER stress using Alzheimer\u2019s disease patient-derived dermal fibroblast: findings from BICWALZS cohort\u2019, Alzheimer\u2019s & Dementia, 19(S13), p. e074781. Available at: https:\/\/doi.org\/10.1002\/ALZ.074781","DOI":"10.1002\/ALZ.074781"},{"key":"1726_CR19","doi-asserted-by":"publisher","unstructured":"Stelzer G et al (2016) \u2018The GeneCards suite: From gene data mining to disease genome sequence analyses\u2019, Current Protocols in Bioinformatics, 2016(1), p. 1.30.1\u20131.30.33. Available at: https:\/\/doi.org\/10.1002\/CPBI.5;JOURNAL:JOURNAL:1934340X;WGROUP:STRING:PUBLICATION","DOI":"10.1002\/CPBI.5"},{"key":"1726_CR121","doi-asserted-by":"publisher","unstructured":"Stoner MW et al (2020) \u2018Calreticulin expression in human cardiac myocytes induces ER stress-associated apoptosis\u2019, Physiological reports, 8(8). Available at: https:\/\/doi.org\/10.14814\/PHY2.14400","DOI":"10.14814\/PHY2.14400"},{"key":"1726_CR22","doi-asserted-by":"publisher","unstructured":"Sun X, Qiu H (2020) \u2018Valosin-Containing Protein, a Calcium-Associated ATPase Protein, in Endoplasmic Reticulum and Mitochondrial Function and Its Implications for Diseases\u2019, International Journal of Molecular Sciences, 21(11), p. 3842. Available at: https:\/\/doi.org\/10.3390\/IJMS21113842","DOI":"10.3390\/IJMS21113842"},{"key":"1726_CR21","doi-asserted-by":"publisher","unstructured":"Suzuki M et al (2022) \u2018Upregulation of ribosome complexes at the blood-brain barrier in Alzheimer\u2019s disease patients\u2019, Journal of Cerebral Blood Flow & Metabolism, 42(11), p. 2134. Available at: https:\/\/doi.org\/10.1177\/0271678X221111602","DOI":"10.1177\/0271678X221111602"},{"key":"1726_CR20","doi-asserted-by":"publisher","unstructured":"Szklarczyk D et al (2023) \u2018The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest\u2019, Nucleic Acids Research, 51(1 D), pp. D638\u2013D646. Available at: https:\/\/doi.org\/10.1093\/NAR\/GKAC1000","DOI":"10.1093\/NAR\/GKAC1000"},{"issue":"5","key":"1726_CR99","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.molcel.2018.04.021","volume":"70","author":"A Turakhiya","year":"2018","unstructured":"Turakhiya A et al (2018) Zfand1 recruits p97 and the 26S proteasome to promote the clearance of arsenite-induced stress granules. Mol Cell 70(5):906-919.e7. https:\/\/doi.org\/10.1016\/j.molcel.2018.04.021","journal-title":"Mol Cell"},{"issue":"1","key":"1726_CR101","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-08880-5","volume":"8","author":"Q Wang","year":"2025","unstructured":"Wang Q et al (2025) Cryo-EM structure of the human Derlin-1\/p97 complex reveals a hexameric channel in ERAD. Commun Biol 8(1):1481. https:\/\/doi.org\/10.1038\/s42003-025-08880-5","journal-title":"Commun Biol"},{"issue":"14","key":"1726_CR100","doi-asserted-by":"publisher","DOI":"10.1002\/PMIC.201700478","volume":"18","author":"X Wang","year":"2018","unstructured":"Wang X et al (2018) Systematic in-depth proteomic analysis of mitochondria-associated endoplasmic reticulum membranes in mouse and human testes. Proteomics 18(14):1700478. https:\/\/doi.org\/10.1002\/PMIC.201700478","journal-title":"Proteomics"},{"issue":"11","key":"1726_CR102","doi-asserted-by":"publisher","first-page":"4606","DOI":"10.1091\/MBC.E06-05-0432","volume":"17","author":"C W\u00f3jcik","year":"2006","unstructured":"W\u00f3jcik C et al (2006) Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells. Mol Biol Cell 17(11):4606. https:\/\/doi.org\/10.1091\/MBC.E06-05-0432","journal-title":"Mol Biol Cell"},{"issue":"17","key":"1726_CR103","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS13171498","volume":"13","author":"D Wolf","year":"2024","unstructured":"Wolf D et al (2024) An essential role for calnexin in ER-phagy and the unfolded protein response. Cells 2024, Vol. 13, Page 1498 13(17):1498. https:\/\/doi.org\/10.3390\/CELLS13171498","journal-title":"Cells 2024, Vol. 13, Page 1498"},{"issue":"3","key":"1726_CR104","doi-asserted-by":"publisher","DOI":"10.1002\/CPZ1.90","volume":"1","author":"Z Xie","year":"2021","unstructured":"Xie Z et al (2021) Gene set knowledge discovery with Enrichr. Curr Protoc 1(3):e90. https:\/\/doi.org\/10.1002\/CPZ1.90","journal-title":"Curr Protoc"},{"key":"1726_CR106","doi-asserted-by":"publisher","unstructured":"Xu P et al (2021) \u2018GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer\u2019s disease\u2019, Journal of Experimental Medicine, 218(8). Available at: https:\/\/doi.org\/10.1084\/JEM.20202446","DOI":"10.1084\/JEM.20202446"},{"issue":"3","key":"1726_CR105","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1091\/MBC.E10-09-0748","volume":"22","author":"S Xu","year":"2011","unstructured":"Xu S et al (2011) The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover. Mol Biol Cell 22(3):291. https:\/\/doi.org\/10.1091\/MBC.E10-09-0748","journal-title":"Mol Biol Cell"},{"issue":"1","key":"1726_CR107","doi-asserted-by":"publisher","DOI":"10.1186\/S12864-024-10363-6","volume":"25","author":"A Yaghoobi","year":"2024","unstructured":"Yaghoobi A, Malekpour SA (2024) Unraveling the genetic architecture of blood unfolded p-53 among non-demented elderlies: novel candidate genes for early Alzheimer\u2019s disease. BMC Genomics 25(1):440. https:\/\/doi.org\/10.1186\/S12864-024-10363-6","journal-title":"BMC Genomics"},{"key":"1726_CR108","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400198R","author":"F Yang","year":"2024","unstructured":"Yang F (2024) Promotion of endoplasmic reticulum retrotranslocation by overexpression of E3 ubiquitin-protein ligase synoviolin 1 reduces endoplasmic reticulum stress and preserves cone photoreceptors in cyclic nucleotide-gated channel deficiency. FASEB J. https:\/\/doi.org\/10.1096\/fj.202400198R","journal-title":"FASEB J"},{"key":"1726_CR18","doi-asserted-by":"publisher","unstructured":"Yang Y et al (2018) \u2018The ER-localized Ca2+-binding protein calreticulin couples ER stress to autophagy by associating with microtubule-associated protein 1A\/1B light chain 3\u2019, The Journal of Biological Chemistry, 294(3), p. 772. Available at: https:\/\/doi.org\/10.1074\/JBC.RA118.005166","DOI":"10.1074\/JBC.RA118.005166"},{"issue":"5","key":"1726_CR109","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/OMI.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G et al (2012) ClusterProfiler: an R package for comparing biological themes among gene clusters. OMICS\u202f: a Journal of Integrative Biology 16(5):284. https:\/\/doi.org\/10.1089\/OMI.2011.0118","journal-title":"OMICS : a Journal of Integrative Biology"},{"key":"1726_CR110","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M111.009936","author":"A Zhang","year":"2011","unstructured":"Zhang A (2011) Quantitative proteomic analyses of human cytomegalovirus-induced restructuring of endoplasmic reticulum-mitochondrial contacts at late times of infection. Mol Cell Proteomics. https:\/\/doi.org\/10.1074\/mcp.M111.009936","journal-title":"Mol Cell Proteomics"},{"issue":"6","key":"1726_CR113","doi-asserted-by":"publisher","DOI":"10.3892\/MMR.2025.13506","volume":"31","author":"J Zhang","year":"2025","unstructured":"Zhang J et al (2025) Current research on mitochondria\u2011associated membranes in cardiovascular diseases (Review). Mol Med Rep 31(6):141. https:\/\/doi.org\/10.3892\/MMR.2025.13506","journal-title":"Mol Med Rep"},{"key":"1726_CR14","doi-asserted-by":"publisher","unstructured":"Zhang L et al (2026) \u2018Mitochondrial double-stranded RNA drives aging-associated cognitive decline\u2019, Cell Research 2026, pp. 1\u201318. Available at: https:\/\/doi.org\/10.1038\/s41422-026-01224-w","DOI":"10.1038\/s41422-026-01224-w"},{"key":"1726_CR112","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8611755","author":"Q Zhang","year":"2022","unstructured":"Zhang Q (2022) Identification of endoplasmic reticulum stress-related biomarkers of periodontitis based on machine learning: a bioinformatics analysis. Dis Markers. https:\/\/doi.org\/10.1155\/2022\/8611755","journal-title":"Dis Markers"},{"key":"1726_CR111","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.17834","volume":"6","author":"T Zhang","year":"2017","unstructured":"Zhang T et al (2017) Valosin-containing protein (VCP\/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants. Elife 6:e17834. https:\/\/doi.org\/10.7554\/ELIFE.17834","journal-title":"Elife"},{"issue":"1","key":"1726_CR114","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-025-00308-0","volume":"6","author":"E Zhao","year":"2025","unstructured":"Zhao E et al (2025) Endoplasmic reticulum-resident protein DNAJC10 inhibits glioblastoma metastasis by suppressing XBP-1s-driven EGFR transcription. Mol Biomed 6(1):84. https:\/\/doi.org\/10.1186\/s43556-025-00308-0","journal-title":"Mol Biomed"},{"key":"1726_CR116","doi-asserted-by":"publisher","DOI":"10.15252\/EMBR.202254859","author":"J Zheng","year":"2022","unstructured":"Zheng J et al (2022) UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy. EMBO Rep. https:\/\/doi.org\/10.15252\/EMBR.202254859","journal-title":"EMBO Rep"},{"issue":"1","key":"1726_CR115","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12964-019-0353-3","volume":"17","author":"W Zheng","year":"2019","unstructured":"Zheng W et al (2019) ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling. Cell Commun Signal 17(1):1\u201316. https:\/\/doi.org\/10.1186\/S12964-019-0353-3","journal-title":"Cell Commun Signal"},{"issue":"8","key":"1726_CR117","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1021\/bi015967+","volume":"41","author":"A Zuppini","year":"2002","unstructured":"Zuppini A et al (2002) Calnexin deficiency and endoplasmic reticulum stress-induced apoptosis. Biochemistry 41(8):2850\u20132858. https:\/\/doi.org\/10.1021\/bi015967+","journal-title":"Biochemistry"}],"container-title":["Cellular and Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10571-026-01726-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-026-01726-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10571-026-01726-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:18:23Z","timestamp":1783646303000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10571-026-01726-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":122,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1726"],"URL":"https:\/\/doi.org\/10.1007\/s10571-026-01726-6","relation":{},"ISSN":["1573-6830"],"issn-type":[{"value":"1573-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"assertion":[{"value":"17 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}],"article-number":"110"}}