{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T22:22:19Z","timestamp":1789856539894,"version":"4.0.1"},"reference-count":213,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chromosome Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An abnormal chromosome number, or aneuploidy, underlies developmental disorders and is a common feature of cancer, with different cancer types exhibiting distinct patterns of chromosomal gains and losses. To understand how specific aneuploidies emerge in certain tissues and how they contribute to disease development, various methods have been developed to alter the karyotype of mammalian cells and mice. In this review, we provide an overview of both classic and novel strategies for inducing or selecting specific chromosomal gains and losses in human and murine cell systems. We highlight how these customized aneuploidy models helped expanding our knowledge of the consequences of specific aneuploidies to (cancer) cell physiology.<\/jats:p>","DOI":"10.1007\/s10577-023-09735-7","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T03:27:10Z","timestamp":1693279630000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Modeling specific aneuploidies: from karyotype manipulations to biological insights"],"prefix":"10.1007","volume":"31","author":[{"given":"My Anh","family":"Truong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Can\u00e9-Gasull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne M. A.","family":"Lens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"9735_CR1","doi-asserted-by":"publisher","unstructured":"Abdel-Hafiz HA, Schafer JM, Chen X, Xiao T, Gauntner TD, Li Z, Theodorescu D (2023) Y chromosome loss in cancer drives growth by evasion of adaptive immunity. Nature. https:\/\/doi.org\/10.1038\/s41586-023-06234-x","DOI":"10.1038\/s41586-023-06234-x"},{"key":"9735_CR2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/2041-9414-1-6","volume":"1","author":"S Abe","year":"2010","unstructured":"Abe S, Tanaka H, Notsu T, Horike S, Fujisaki C, Qi D-L, Ohhira T, Gilley D, Oshimura M, Kugoh H (2010) Localization of an hTERT repressor region on human chromosome 3p21.3 using chromosome engineering. Genome Integr 1:6. https:\/\/doi.org\/10.1186\/2041-9414-1-6","journal-title":"Genome Integr"},{"issue":"5\u20136","key":"9735_CR3","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1101\/gad.350182.122","volume":"37","author":"MAY Adell","year":"2023","unstructured":"Adell MAY, Klockner TC, H\u00f6fler R, Wallner L, Schmid J, Markovic A, Martyniak A, Campbell CS (2023) Adaptation to spindle assembly checkpoint inhibition through the selection of specific aneuploidies. Genes Dev 37(5\u20136):171\u2013190. https:\/\/doi.org\/10.1101\/gad.350182.122","journal-title":"Genes Dev"},{"issue":"8","key":"9735_CR4","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/j.ymthe.2017.05.021","volume":"25","author":"F Adikusuma","year":"2017","unstructured":"Adikusuma F, Williams N, Grutzner F, Hughes J, Thomas P (2017) Targeted deletion of an entire chromosome using CRISPR\/Cas9. Mol Ther 25(8):1736\u20131738. https:\/\/doi.org\/10.1016\/j.ymthe.2017.05.021","journal-title":"Mol Ther"},{"issue":"1","key":"9735_CR5","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3390\/CELLS9010239","volume":"9","author":"SN Akutsu","year":"2020","unstructured":"Akutsu SN, Fujita K, Tomioka K, Miyamoto T, Matsuura S (2020) Applications of genome editing technology in research on chromosome aneuploidy disorders. Cells 9(1):239. https:\/\/doi.org\/10.3390\/CELLS9010239","journal-title":"Cells"},{"issue":"6588","key":"9735_CR6","doi-asserted-by":"publisher","first-page":"eabl4178","DOI":"10.1126\/science.abl4178","volume":"376","author":"N Altemose","year":"2022","unstructured":"Altemose N, Logsdon GA, Bzikadze AV, Sidhwani P, Langley SA, Caldas GV, Hoyt SJ, Uralsky L, Ryabov FD, Shew CJ et al (2022) Complete genomic and epigenetic maps of human centromeres. Science 376(6588):eabl4178. https:\/\/doi.org\/10.1126\/science.abl4178","journal-title":"Science"},{"issue":"10","key":"9735_CR7","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.str.2018.06.013","volume":"26","author":"R Bajaj","year":"2018","unstructured":"Bajaj R, Bollen M, Peti W, Page R (2018) KNL1 binding to PP1 and microtubules is mutually exclusive. Structure 26(10):1327\u20131336.e4. https:\/\/doi.org\/10.1016\/j.str.2018.06.013","journal-title":"Structure"},{"issue":"6","key":"9735_CR8","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.ccr.2009.10.023","volume":"16","author":"DJ Baker","year":"2009","unstructured":"Baker DJ, Jin F, Jeganathan KB, van Deursen JM (2009) Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell 16(6):475\u2013486. https:\/\/doi.org\/10.1016\/j.ccr.2009.10.023","journal-title":"Cancer Cell"},{"issue":"7689","key":"9735_CR9","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nature25432","volume":"553","author":"SF Bakhoum","year":"2018","unstructured":"Bakhoum SF, Ngo B, Laughney AM, Cavallo J-A, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK et al (2018) Chromosomal instability drives metastasis through a cytosolic DNA response. Nature 553(7689):467\u2013472. https:\/\/doi.org\/10.1038\/nature25432","journal-title":"Nature"},{"issue":"1","key":"9735_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13059-016-0971-7","volume":"17","author":"B Bakker","year":"2016","unstructured":"Bakker B, Taudt A, Belderbos ME, Porubsky D, Spierings DCJ, de Jong TV, Halsema N, Kazemier HG, Hoekstra-Wakker K, Bradley A et al (2016) Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies. Genome Biol 17(1):1\u201315. https:\/\/doi.org\/10.1186\/S13059-016-0971-7","journal-title":"Genome Biol"},{"issue":"2","key":"9735_CR11","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/J.CELL.2017.03.021","volume":"169","author":"RR Beach","year":"2017","unstructured":"Beach RR, Ricci-Tam C, Brennan CM, Moomau CA, Hsu P, Hua B, Silberman RE, Springer M, Amon A (2017) aneuploidy causes non-genetic individuality. Cell 169(2):229\u2013242.e21. https:\/\/doi.org\/10.1016\/J.CELL.2017.03.021","journal-title":"Cell"},{"issue":"1","key":"9735_CR12","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41576-019-0171-x","volume":"21","author":"U Ben-David","year":"2019","unstructured":"Ben-David U, Amon A (2019) Context is everything: aneuploidy in cancer. Nat Rev Genet 21(1):44\u201362. https:\/\/doi.org\/10.1038\/s41576-019-0171-x","journal-title":"Nat Rev Genet"},{"issue":"3","key":"9735_CR13","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/J.SCR.2012.07.002","volume":"9","author":"JC Biancotti","year":"2012","unstructured":"Biancotti JC, Narwani K, Mandefro B, Golan-Lev T, Buehler N, Hill D, Svendsen CN, Benvenisty N (2012) The in vitro survival of human monosomies and trisomies as embryonic stem cells. Stem Cell Res 9(3):218\u2013224. https:\/\/doi.org\/10.1016\/J.SCR.2012.07.002","journal-title":"Stem Cell Res"},{"issue":"1","key":"9735_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s43586-021-00093-4","volume":"2","author":"C Bock","year":"2022","unstructured":"Bock C, Datlinger P, Chardon F, Coelho MA, Dong MB, Lawson KA, Lu T, Maroc L, Norman TM, Song B, Stanley G et al (2022) High-content CRISPR screening. Nat Rev Methods Primer 2(1):1\u201323. https:\/\/doi.org\/10.1038\/s43586-021-00093-4","journal-title":"Nat Rev Methods Primer"},{"issue":"20","key":"9735_CR15","doi-asserted-by":"publisher","first-page":"7572","DOI":"10.1073\/pnas.85.20.7572","volume":"85","author":"E Borrelli","year":"1988","unstructured":"Borrelli E, Heyman R, Hsi M, Evans RM (1988) Targeting of an inducible toxic phenotype in animal cells. Proc Natl Acad Sci 85(20):7572\u20137576. https:\/\/doi.org\/10.1073\/pnas.85.20.7572","journal-title":"Proc Natl Acad Sci"},{"issue":"9","key":"9735_CR16","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1016\/j.cell.2023.03.02910.1101\/2022.09.27.509580","volume":"186","author":"N Bosco","year":"2023","unstructured":"Bosco N, Goldberg A, Zhao X, Mays JC, Cheng P, Johnson AF, Bianchi JJ, Toscani C, Katsnelson L, Annuar D et al (2023) KaryoCreate: a CRISPR-based technology to study chromosome-specific aneuploidy by targeting human centromeres. Cell 186(9):1985\u20132001.e19. https:\/\/doi.org\/10.1016\/j.cell.2023.03.02910.1101\/2022.09.27.509580","journal-title":"Cell"},{"issue":"20","key":"9735_CR17","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1093\/hmg\/10.20.2225","volume":"10","author":"R Boumil","year":"2001","unstructured":"Boumil R, Lee JT (2001) Forty years of decoding the silence in X-chromosome inactivation. Hum Mol Genet 10(20):2225\u20132232. https:\/\/doi.org\/10.1093\/hmg\/10.20.2225","journal-title":"Hum Mol Genet"},{"issue":"Supplement 1","key":"9735_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1242\/jcs.025742","volume":"121","author":"T Boveri","year":"2008","unstructured":"Boveri T (2008) Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J Cell Sci 121(Supplement 1):1\u201384. https:\/\/doi.org\/10.1242\/jcs.025742","journal-title":"J Cell Sci"},{"issue":"5","key":"9735_CR19","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.ccell.2016.04.003","volume":"29","author":"Y Cai","year":"2016","unstructured":"Cai Y, Crowther J, Pastor T, Abbasi Asbagh L, Baietti MF, De Troyer M, Vazquez I, Talebi A, Renzi F, Dehairs J, Swinnen JV, Sablina AA (2016) Loss of chromosome 8p governs tumor progression and drug response by altering lipid metabolism. Cancer Cell 29(5):751\u2013766. https:\/\/doi.org\/10.1016\/j.ccell.2016.04.003","journal-title":"Cancer Cell"},{"issue":"4","key":"9735_CR20","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/BF00292842","volume":"58","author":"E Capanna","year":"1976","unstructured":"Capanna E, Gropp A, Winking H, Noack G, Civitelli M-V (1976) Robertsonian metacentrics in the mouse. Chromosoma 58(4):341\u2013353. https:\/\/doi.org\/10.1007\/BF00292842","journal-title":"Chromosoma"},{"issue":"1","key":"9735_CR21","doi-asserted-by":"publisher","first-page":"5180","DOI":"10.1038\/s41467-018-07630-y","volume":"9","author":"J-C Chiang","year":"2018","unstructured":"Chiang J-C, Jiang J, Newburger PE, Lawrence JB (2018) Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro. Nat Commun 9(1):5180. https:\/\/doi.org\/10.1038\/s41467-018-07630-y","journal-title":"Nat Commun"},{"issue":"1","key":"9735_CR22","doi-asserted-by":"publisher","first-page":"5576","DOI":"10.1038\/s41467-021-25288-x","volume":"12","author":"NK Chunduri","year":"2021","unstructured":"Chunduri NK, Menges P, Zhang X, Wieland A, Gotsmann VL, Mardin BR, Buccitelli C, Korbel JO, Willmund F, Kschischo M, Raeschle M, Storchova Z (2021) Systems approaches identify the consequences of monosomy in somatic human cells. Nat Commun 12(1):5576. https:\/\/doi.org\/10.1038\/s41467-021-25288-x","journal-title":"Nat Commun"},{"issue":"3","key":"9735_CR23","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1083\/jcb.153.3.517","volume":"153","author":"D Cimini","year":"2001","unstructured":"Cimini D, Howell B, Maddox P, Khodjakov A, Degrassi F, Salmon ED (2001) Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J Cell Biol 153(3):517\u2013528. https:\/\/doi.org\/10.1083\/jcb.153.3.517","journal-title":"J Cell Biol"},{"issue":"3","key":"9735_CR24","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41588-019-0576-7","volume":"52","author":"I Cort\u00e9s-Ciriano","year":"2020","unstructured":"Cort\u00e9s-Ciriano I, Lee JJ-K, Xi R, Jain D, Jung YL, Yang L, Gordenin D, Klimczak LJ, Zhang C-Z, Pellman DS, Park PJ (2020) Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing. Nat Genet 52(3):331\u2013341. https:\/\/doi.org\/10.1038\/s41588-019-0576-7","journal-title":"Nat Genet"},{"issue":"7383","key":"9735_CR25","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/nature10802","volume":"482","author":"K Crasta","year":"2012","unstructured":"Crasta K, Ganem NJ, Dagher R, Lantermann AB, Ivanova EV, Pan Y, Nezi L, Protopopov A, Chowdhury D, Pellman D (2012) DNA breaks and chromosome pulverization from errors in mitosis. Nature 482(7383):53\u201358. https:\/\/doi.org\/10.1038\/nature10802","journal-title":"Nature"},{"issue":"3","key":"9735_CR26","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.devcel.2019.12.015","volume":"52","author":"JT Czermi\u0144ski","year":"2020","unstructured":"Czermi\u0144ski JT, Lawrence JB (2020) Silencing trisomy 21 with XIST in neural stem cells promotes neuronal differentiation. Dev Cell 52(3):294\u2013308.e3. https:\/\/doi.org\/10.1016\/j.devcel.2019.12.015","journal-title":"Dev Cell"},{"issue":"24","key":"9735_CR27","doi-asserted-by":"publisher","first-page":"7824","DOI":"10.1073\/pnas.79.24.7824","volume":"79","author":"R Dalla-Favera","year":"1982","unstructured":"Dalla-Favera R, Bregni M, Erikson J, Patterson D, Gallo RC, Croce CM (1982) Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci 79(24):7824\u20137827. https:\/\/doi.org\/10.1073\/pnas.79.24.7824","journal-title":"Proc Natl Acad Sci"},{"issue":"12","key":"9735_CR28","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/J.CUB.2011.05.032","volume":"21","author":"JR Daum","year":"2011","unstructured":"Daum JR, Potapova TA, Sivakumar S, Daniel JJ, Flynn JN, Rankin S, Gorbsky GJ (2011) Cohesion fatigue induces chromatid separation in cells delayed at metaphase. Curr Biol 21(12):1018\u20131024. https:\/\/doi.org\/10.1016\/J.CUB.2011.05.032","journal-title":"Curr Biol"},{"issue":"4","key":"9735_CR29","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.cell.2013.10.011","volume":"155","author":"T Davoli","year":"2013","unstructured":"Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ (2013) Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell 155(4):948. https:\/\/doi.org\/10.1016\/j.cell.2013.10.011","journal-title":"Cell"},{"issue":"1","key":"9735_CR30","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1038\/s41467-023-36790-9","volume":"14","author":"A De Falco","year":"2023","unstructured":"De Falco A, Caruso F, Su X-D, Iavarone A, Ceccarelli M (2023) A variational algorithm to detect the clonal copy number substructure of tumors from scRNA-seq data. Nat Commun 14(1):1074. https:\/\/doi.org\/10.1038\/s41467-023-36790-9","journal-title":"Nat Commun"},{"issue":"10","key":"9735_CR31","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1016\/j.stem.2021.07.012","volume":"28","author":"JK de Kanter","year":"2021","unstructured":"de Kanter JK, Peci F, Bertrums E, Rosendahl Huber A, van Leeuwen A, van Roosmalen MJ, Manders F, Verheul M, Oka R, Brandsma AM, Bierings M, Belderbos M, van Boxtel R (2021) Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients. Cell Stem Cell 28(10):1726\u20131739.e6. https:\/\/doi.org\/10.1016\/j.stem.2021.07.012","journal-title":"Cell Stem Cell"},{"issue":"5","key":"9735_CR32","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.cell.2006.09.047","volume":"127","author":"JG DeLuca","year":"2006","unstructured":"DeLuca JG, Gall WE, Ciferri C, Cimini D, Musacchio A, Salmon ED (2006) Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell 127(5):969\u2013982. https:\/\/doi.org\/10.1016\/j.cell.2006.09.047","journal-title":"Cell"},{"issue":"11","key":"9735_CR33","doi-asserted-by":"publisher","first-page":"3637","DOI":"10.1073\/pnas.79.11.3637","volume":"79","author":"CJ Der","year":"1982","unstructured":"Der CJ, Krontiris TG, Cooper GM (1982) Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci 79(11):3637\u20133640. https:\/\/doi.org\/10.1073\/pnas.79.11.3637","journal-title":"Proc Natl Acad Sci"},{"issue":"2","key":"9735_CR34","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1083\/jcb.200208091","volume":"161","author":"C Ditchfield","year":"2003","unstructured":"Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, Mortlock A, Keen N, Taylor SS (2003) Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol 161(2):267\u2013280. https:\/\/doi.org\/10.1083\/jcb.200208091","journal-title":"J Cell Biol"},{"issue":"2","key":"9735_CR35","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1093\/NAR\/GKAA1241","volume":"49","author":"G Doi","year":"2021","unstructured":"Doi G, Okada S, Yasukawa T, Sugiyama Y, Bala S, Miyazaki S, Kang D, Ito T (2021) Catalytically inactive Cas9 impairs DNA replication fork progression to induce focal genomic instability. Nucleic Acids Res 49(2):954\u2013968. https:\/\/doi.org\/10.1093\/NAR\/GKAA1241","journal-title":"Nucleic Acids Res"},{"issue":"5212","key":"9735_CR36","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1126\/science.7754374","volume":"268","author":"J-T Dong","year":"1995","unstructured":"Dong J-T, Lamb PW, Rinker-Schaeffer CW, Vukanovic J, Ichikawa T, Isaacs JT, Barrett JC (1995) KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science 268(5212):884\u2013886. https:\/\/doi.org\/10.1126\/science.7754374","journal-title":"Science"},{"issue":"9","key":"9735_CR37","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.cub.2018.03.023","volume":"28","author":"D Drpic","year":"2018","unstructured":"Drpic D, Almeida AC, Aguiar P, Renda F, Damas J, Lewin HA, Larkin DM, Khodjakov A, Maiato H (2018) Chromosome segregation is biased by kinetochore size. Curr Biol 28(9):1344\u20131356.e5. https:\/\/doi.org\/10.1016\/j.cub.2018.03.023","journal-title":"Curr Biol"},{"issue":"1","key":"9735_CR38","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1534\/genetics.108.092312","volume":"180","author":"A Duchon","year":"2008","unstructured":"Duchon A, Besson V, Pereira PL, Magnol L, H\u00e9rault Y (2008) Inducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombination. Genetics 180(1):51\u201359. https:\/\/doi.org\/10.1534\/genetics.108.092312","journal-title":"Genetics"},{"issue":"10","key":"9735_CR39","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1002\/ijc.27924","volume":"132","author":"PHG Duijf","year":"2013","unstructured":"Duijf PHG, Schultz N, Benezra R (2013) Cancer cells preferentially lose small chromosomes. Int J Cancer 132(10):2316\u20132326. https:\/\/doi.org\/10.1002\/ijc.27924","journal-title":"Int J Cancer"},{"issue":"6","key":"9735_CR40","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.ajhg.2016.05.014","volume":"98","author":"JP Dumanski","year":"2016","unstructured":"Dumanski JP, Lambert J-C, Rasi C, Giedraitis V, Davies H, Grenier-Boley B, Lindgren CM, Campion D, Dufouil C, Pasquier F, Amouyel P, Lannfelt L, Ingelsson M, Kilander L, Lind L, Forsberg LA (2016) Mosaic loss of chromosome Y in blood is associated with Alzheimer disease. Am J Hum Genet 98(6):1208\u20131219. https:\/\/doi.org\/10.1016\/j.ajhg.2016.05.014","journal-title":"Am J Hum Genet"},{"issue":"2","key":"9735_CR41","doi-asserted-by":"publisher","first-page":"e102924","DOI":"10.15252\/EMBJ.2019102924","volume":"39","author":"M Dumont","year":"2020","unstructured":"Dumont M, Gamba R, Gestraud P, Klaasen S, Worrall JT, Vries SGD, Boudreau V, Salinas-Luypaert C, Maddox PS, Lens SM, Kops GJ, McClelland SE, Miga KH, Fachinetti D (2020) Human chromosome-specific aneuploidy is influenced by DNA-dependent centromeric features. EMBO J 39(2):e102924. https:\/\/doi.org\/10.15252\/EMBJ.2019102924","journal-title":"EMBO J"},{"issue":"1","key":"9735_CR42","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/1471-2164-15-139","volume":"15","author":"M D\u00fcrrbaum","year":"2014","unstructured":"D\u00fcrrbaum M, Kuznetsova A, Passerini V, Stingele S, Stoehr G, Storchov\u00e1 Z (2014) Unique features of the transcriptional response to model aneuploidy in human cells. BMC Genomics 15(1):139. https:\/\/doi.org\/10.1186\/1471-2164-15-139","journal-title":"BMC Genomics"},{"issue":"1","key":"9735_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00293329","volume":"98","author":"WC Earnshaw","year":"1989","unstructured":"Earnshaw WC, Ratrie H, Stetten G (1989) Visualization of centromere proteins CENP-B and CENP-C on a stable dicentric chromosome in cytological spreads. Chromosoma 98(1):1\u201312. https:\/\/doi.org\/10.1007\/BF00293329","journal-title":"Chromosoma"},{"issue":"21","key":"9735_CR44","doi-asserted-by":"publisher","first-page":"12007","DOI":"10.1093\/nar\/gkab557","volume":"49","author":"TF Eleveld","year":"2021","unstructured":"Eleveld TF, Bakali C, Eijk PP, Stathi P, Vriend LE, Poddighe PJ, Ylstra B (2021) Engineering large-scale chromosomal deletions by CRISPR-Cas9. Nucleic Acids Res 49(21):12007\u201312016. https:\/\/doi.org\/10.1093\/nar\/gkab557","journal-title":"Nucleic Acids Res"},{"issue":"6147","key":"9735_CR45","doi-asserted-by":"publisher","first-page":"1237973","DOI":"10.1126\/science.1237973","volume":"341","author":"JM Engreitz","year":"2013","unstructured":"Engreitz JM, Pandya-Jones A, McDonel P, Shishkin A, Sirokman K, Surka C, Kadri S, Xing J, Goren A, Lander ES, Plath K, Guttman M (2013) The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome. Science 341(6147):1237973. https:\/\/doi.org\/10.1126\/science.1237973","journal-title":"Science"},{"issue":"7922","key":"9735_CR46","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/s41586-022-05023-2","volume":"608","author":"A Erickson","year":"2022","unstructured":"Erickson A, He M, Berglund E, Marklund M, Mirzazadeh R, Schultz N, Kvastad L, Andersson A, Bergenstr\u00e5hle L, Bergenstr\u00e5hle J et al (2022) Spatially resolved clonal copy number alterations in benign and malignant tissue. Nature 608(7922):360\u2013367. https:\/\/doi.org\/10.1038\/s41586-022-05023-2","journal-title":"Nature"},{"issue":"4","key":"9735_CR47","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1083\/jcb.201111107","volume":"196","author":"J Espeut","year":"2012","unstructured":"Espeut J, Cheerambathur DK, Krenning L, Oegema K, Desai A (2012) Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore. J Cell Biol 196(4):469\u2013482. https:\/\/doi.org\/10.1083\/jcb.201111107","journal-title":"J Cell Biol"},{"issue":"3","key":"9735_CR48","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.devcel.2015.03.020","volume":"33","author":"D Fachinetti","year":"2015","unstructured":"Fachinetti D, Han JS, McMahon MA, Ly P, Abdullah A, Wong AJ, Cleveland DW (2015) DNA sequence-specific binding of CENP-B enhances the fidelity of human centromere function. Dev Cell 33(3):314\u2013327. https:\/\/doi.org\/10.1016\/j.devcel.2015.03.020","journal-title":"Dev Cell"},{"key":"9735_CR49","doi-asserted-by":"publisher","unstructured":"Foijer F, Albacker LA, Bakker B, Spierings DC, Yue Y, Xie SZ, Davis S, Lutum-Jehle A, Takemoto D, Hare B, et al. (2017) Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma. eLife 6:e20873. https:\/\/doi.org\/10.7554\/eLife.20873","DOI":"10.7554\/eLife.20873"},{"issue":"37","key":"9735_CR50","doi-asserted-by":"publisher","first-page":"13427","DOI":"10.1073\/pnas.1400892111","volume":"111","author":"F Foijer","year":"2014","unstructured":"Foijer F, Xie SZ, Simon JE, Bakker PL, Conte N, Davis SH, Kregel E, Jonkers J, Bradley A, Sorger PK (2014) Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress. Proc Natl Acad Sci U S A 111(37):13427\u201313432. https:\/\/doi.org\/10.1073\/pnas.1400892111","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"9735_CR51","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/ng.2966","volume":"46","author":"LA Forsberg","year":"2014","unstructured":"Forsberg LA, Rasi C, Malmqvist N, Davies H, Pasupulati S, Pakalapati G, Sandgren J, Diaz de St\u00e5hl T, Zaghlool A et al (2014) Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer. Nat Genet 46(6):624\u2013628. https:\/\/doi.org\/10.1038\/ng.2966","journal-title":"Nat Genet"},{"issue":"1","key":"9735_CR52","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1073\/pnas.74.1.319","volume":"74","author":"RE Fournier","year":"1977","unstructured":"Fournier RE, Ruddle FH (1977) Microcell-mediated transfer of murine chromosomes into mouse, Chinese hamster, and human somatic cells. Proc Natl Acad Sci 74(1):319\u2013323. https:\/\/doi.org\/10.1073\/pnas.74.1.319","journal-title":"Proc Natl Acad Sci"},{"issue":"7","key":"9735_CR53","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s00439-017-1797-4","volume":"136","author":"E Fragouli","year":"2017","unstructured":"Fragouli E, Alfarawati S, Spath K, Babariya D, Tarozzi N, Borini A, Wells D (2017) Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts. Hum Genet 136(7):805\u2013819. https:\/\/doi.org\/10.1007\/s00439-017-1797-4","journal-title":"Hum Genet"},{"issue":"3","key":"9735_CR54","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41587-022-01468-y","volume":"41","author":"T Gao","year":"2023","unstructured":"Gao T, Soldatov R, Sarkar H, Kurkiewicz A, Biederstedt E, Loh P-R, Kharchenko PV (2023) Haplotype-aware analysis of somatic copy number variations from single-cell transcriptomes. Nat Biotechnol 41(3):417\u2013426. https:\/\/doi.org\/10.1038\/s41587-022-01468-y","journal-title":"Nat Biotechnol"},{"issue":"6","key":"9735_CR55","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00412-014-0477-6","volume":"123","author":"S Garagna","year":"2014","unstructured":"Garagna S, Page J, Fernandez-Donoso R, Zuccotti M, Searle JB (2014) The Robertsonian phenomenon in the house mouse: mutation, meiosis and speciation. Chromosoma 123(6):529\u2013544. https:\/\/doi.org\/10.1007\/s00412-014-0477-6","journal-title":"Chromosoma"},{"issue":"4","key":"9735_CR56","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s10577-013-9368-6","volume":"21","author":"KE Gascoigne","year":"2013","unstructured":"Gascoigne KE, Cheeseman IM (2013) Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis. Chromosome Res 21(4):407\u2013418. https:\/\/doi.org\/10.1007\/s10577-013-9368-6","journal-title":"Chromosome Res"},{"issue":"3","key":"9735_CR57","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.cell.2011.03.031","volume":"145","author":"KE Gascoigne","year":"2011","unstructured":"Gascoigne KE, Takeuchi K, Suzuki A, Hori T, Fukagawa T, Cheeseman IM (2011) Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes. Cell 145(3):410\u2013422. https:\/\/doi.org\/10.1016\/j.cell.2011.03.031","journal-title":"Cell"},{"issue":"3","key":"9735_CR58","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.cell.2014.09.029","volume":"159","author":"LA Gilbert","year":"2014","unstructured":"Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS (2014) Genome-scale CRISPR-mediated control of gene repression and activation. Cell 159(3):647\u2013661. https:\/\/doi.org\/10.1016\/j.cell.2014.09.029","journal-title":"Cell"},{"issue":"2","key":"9735_CR59","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/J.CELL.2013.06.044","volume":"154","author":"LA Gilbert","year":"2013","unstructured":"Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS (2013) CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell 154(2):442\u2013451. https:\/\/doi.org\/10.1016\/J.CELL.2013.06.044","journal-title":"Cell"},{"issue":"9","key":"9735_CR60","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1002\/yea.3427","volume":"36","author":"C Gilchrist","year":"2019","unstructured":"Gilchrist C, Stelkens R (2019) Aneuploidy in yeast: segregation error or adaptation mechanism? Yeast 36(9):525\u2013539. https:\/\/doi.org\/10.1002\/yea.3427","journal-title":"Yeast"},{"key":"9735_CR61","doi-asserted-by":"publisher","unstructured":"Girish V, Lakhani AA, Thompson SL, Scaduto CM, Brown LM, Hagenson RA, Sausville EL, Mendelson BE, Kandikuppa PK, Lukow DA et al (2023) Oncogene-like addiction to aneuploidy in human cancers. Science:eadg4521. https:\/\/doi.org\/10.1126\/science.adg4521","DOI":"10.1126\/science.adg4521"},{"issue":"2","key":"9735_CR62","first-page":"432","volume":"63","author":"SF Goldberg","year":"2003","unstructured":"Goldberg SF, Miele ME, Hatta N, Takata M, Paquette-Straub C, Freedman LP, Welch DR (2003) Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP1. Cancer Res 63(2):432\u2013440","journal-title":"Cancer Res"},{"issue":"38","key":"9735_CR63","doi-asserted-by":"publisher","first-page":"14492","DOI":"10.1073\/pnas.0807484105","volume":"105","author":"D Gr\u00e9goire","year":"2008","unstructured":"Gr\u00e9goire D, Kmita M (2008) Recombination between inverted loxP sites is cytotoxic for proliferating cells and provides a simple tool for conditional cell ablation. Proc Natl Acad Sci U S A 105(38):14492\u201314496. https:\/\/doi.org\/10.1073\/pnas.0807484105","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"9735_CR64","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1146\/annurev-genet-072820-033609","volume":"56","author":"JR Gruhn","year":"2022","unstructured":"Gruhn JR, Hoffmann ER (2022) Errors of the Egg: the establishment and progression of human aneuploidy research in the maternal germline. Annu Rev Genet 56(1):369\u2013390. https:\/\/doi.org\/10.1146\/annurev-genet-072820-033609","journal-title":"Annu Rev Genet"},{"issue":"1","key":"9735_CR65","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0165-4608(94)00099-w","volume":"79","author":"H Hasle","year":"1995","unstructured":"Hasle H, Clausen N, Pedersen B, Bendix-Hansen K (1995) Myelodysplastic syndrome in a child with constitutional trisomy 8 mosaicism and normal phenotype. Cancer Genet Cytogenet 79(1):79\u201381. https:\/\/doi.org\/10.1016\/0165-4608(94)00099-w","journal-title":"Cancer Genet Cytogenet"},{"issue":"2","key":"9735_CR66","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/j.1469-1809.1980.tb00955.x","volume":"44","author":"T Hassold","year":"1980","unstructured":"Hassold T, Chen N, Funkhouser J, Jooss T, Manuel B, Matsuura J, Matsuyama A, Wilson C, Yamane JA, Jacobs PA (1980) A cytogenetic study of 1000 spontaneous abortions. Ann Hum Genet 44(2):151\u2013164. https:\/\/doi.org\/10.1111\/j.1469-1809.1980.tb00955.x","journal-title":"Ann Hum Genet"},{"issue":"1","key":"9735_CR67","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1146\/annurev.ge.18.120184.000441","volume":"18","author":"TJ Hassold","year":"1984","unstructured":"Hassold TJ, Jacobs PA (1984) Trisomy in Man. Annu Rev Genet 18(1):69\u201397. https:\/\/doi.org\/10.1146\/annurev.ge.18.120184.000441","journal-title":"Annu Rev Genet"},{"issue":"2","key":"9735_CR68","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1083\/jcb.200208092","volume":"161","author":"S Hauf","year":"2003","unstructured":"Hauf S, Cole RW, LaTerra S, Zimmer C, Schnapp G, Walter R, Heckel A, Van Meel J, Rieder CL, Peters JM (2003) The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol 161(2):281\u2013294. https:\/\/doi.org\/10.1083\/jcb.200208092","journal-title":"J Cell Biol"},{"issue":"6","key":"9735_CR69","doi-asserted-by":"publisher","first-page":"470","DOI":"10.2174\/138920210793176038","volume":"11","author":"Y H\u00e9rault","year":"2010","unstructured":"H\u00e9rault Y, Duchon A, Mar\u00e9chal D, Raveau M, Pereira PL, Dalloneau E, Brault V (2010) Controlled somatic and germline copy number variation in the mouse model. Curr Genomics 11(6):470\u2013480. https:\/\/doi.org\/10.2174\/138920210793176038","journal-title":"Curr Genomics"},{"issue":"7","key":"9735_CR70","doi-asserted-by":"publisher","first-page":"e0268579","DOI":"10.1371\/JOURNAL.PONE.0268579","volume":"17","author":"DC Hintzen","year":"2022","unstructured":"Hintzen DC, Soto M, Schubert M, Bakker B, Spierings DCJ, Szuhai K, Lansdorp PM, RJC K, Foijer F, Medema RH, Raaijmakers JA (2022) The impact of monosomies, trisomies and segmental aneuploidies on chromosomal stability. PLoS One 17(7):e0268579. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0268579","journal-title":"PLoS One"},{"issue":"1","key":"9735_CR71","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1038\/s41467-020-15279-9","volume":"11","author":"WHM Hoevenaar","year":"2020","unstructured":"Hoevenaar WHM, Janssen A, Quirindongo AI, Ma H, Klaasen SJ, Teixeira A, van Gerwen B, Lansu N, Morsink FHM, Offerhaus GJA, Medema RH, Kops GJPL, Jelluma N (2020) Degree and site of chromosomal instability define its oncogenic potential. Nat Commun 11(1):1501. https:\/\/doi.org\/10.1038\/s41467-020-15279-9","journal-title":"Nat Commun"},{"issue":"17","key":"9735_CR72","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1016\/J.DEVCEL.2021.07.006","volume":"56","author":"MR Ippolito","year":"2021","unstructured":"Ippolito MR, Martis V, Martin S, Tijhuis AE, Hong C, Wardenaar R, Dumont M, Zerbib J, Spierings DCJ, Fachinetti D, Ben-David U, Foijer F, Santaguida S (2021) Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy. Dev Cell 56(17):2440\u20132454.e6. https:\/\/doi.org\/10.1016\/J.DEVCEL.2021.07.006","journal-title":"Dev Cell"},{"issue":"1","key":"9735_CR73","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1158\/0008-5472.CAN-06-3326","volume":"67","author":"Y Iwanaga","year":"2007","unstructured":"Iwanaga Y, Chi Y-H, Miyazato A, Sheleg S, Haller K, Peloponese J-M Jr, Li Y, Ward JM, Benezra R, Jeang K-T (2007) Heterozygous deletion of mitotic arrest\u2013deficient protein 1 (MAD1) increases the incidence of tumors in mice. Cancer Res 67(1):160\u2013166. https:\/\/doi.org\/10.1158\/0008-5472.CAN-06-3326","journal-title":"Cancer Res"},{"issue":"7462","key":"9735_CR74","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/nature12394","volume":"500","author":"J Jiang","year":"2013","unstructured":"Jiang J, Jing Y, Cost GJ, Chiang JC, Kolpa HJ, Cotton AM, Carone DM, Carone BR, Shivak DA, Guschin DY et al (2013) Translating dosage compensation to trisomy 21. Nature 500(7462):296\u2013300. https:\/\/doi.org\/10.1038\/nature12394","journal-title":"Nature"},{"issue":"7","key":"9735_CR75","doi-asserted-by":"publisher","first-page":"15087","DOI":"10.1038\/nplants.2015.87","volume":"1","author":"E Jonsson","year":"2015","unstructured":"Jonsson E, Yamada M, Vale RD, Goshima G (2015) Clustering of a kinesin-14 motor enables processive retrograde microtubule-based transport in plants. Nat Plants 1(7):15087. https:\/\/doi.org\/10.1038\/nplants.2015.87","journal-title":"Nat Plants"},{"issue":"5759","key":"9735_CR76","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1126\/science.1122142","volume":"311","author":"TM Kapoor","year":"2006","unstructured":"Kapoor TM, Lampson MA, Hergert P, Cameron L, Cimini D, Salmon ED, McEwen BF, Khodjakov A (2006) Chromosomes can congress to the metaphase plate before biorientation. Science 311(5759):388\u2013391. https:\/\/doi.org\/10.1126\/science.1122142","journal-title":"Science"},{"issue":"9","key":"9735_CR77","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1038\/s12276-020-00499-2","volume":"52","author":"Y Kashima","year":"2020","unstructured":"Kashima Y, Sakamoto Y, Kaneko K, Seki M, Suzuki Y, Suzuki A (2020) Single-cell sequencing techniques from individual to multiomics analyses. Exp Mol Med 52(9):1419\u20131427. https:\/\/doi.org\/10.1038\/s12276-020-00499-2","journal-title":"Exp Mol Med"},{"key":"9735_CR78","doi-asserted-by":"publisher","first-page":"e56223","DOI":"10.7554\/eLife.56223","volume":"9","author":"Y Kazuki","year":"2020","unstructured":"Kazuki Y, Gao FJ, Li Y, Moyer AJ, Devenney B, Hiramatsu K, Miyagawa-Tomita S, Abe S, Kazuki K, Kajitani N et al (2020) A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21. eLife 9:e56223. https:\/\/doi.org\/10.7554\/eLife.56223","journal-title":"eLife"},{"issue":"1","key":"9735_CR79","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s13059-015-0774-2","volume":"16","author":"AD Kelsey","year":"2015","unstructured":"Kelsey AD, Yang C, Leung D, Minks J, Dixon-McDougall T, Baldry SEL, Bogutz AB, Lefebvre L, Brown CJ (2015) Impact of flanking chromosomal sequences on localization and silencing by the human non-coding RNA XIST. Genome Biol 16(1):208. https:\/\/doi.org\/10.1186\/s13059-015-0774-2","journal-title":"Genome Biol"},{"issue":"2","key":"9735_CR80","doi-asserted-by":"publisher","first-page":"100096","DOI":"10.1016\/j.xgen.2022.100096","volume":"2","author":"L Kester","year":"2022","unstructured":"Kester L, de Barbanson B, Lyubimova A, Chen L-T, van der Schrier V, Alemany A, Mooijman D, Peterson-Maduro J, Drost J, de Ridder J, van Oudenaarden A (2022) Integration of multiple lineage measurements from the same cell reconstructs parallel tumor evolution. Cell Genomics 2(2):100096. https:\/\/doi.org\/10.1016\/j.xgen.2022.100096","journal-title":"Cell Genomics"},{"issue":"22","key":"9735_CR81","doi-asserted-by":"publisher","first-page":"3564","DOI":"10.3390\/cells11223564","volume":"11","author":"SJ Klaasen","year":"2022","unstructured":"Klaasen SJ, Kops GJPL (2022) Chromosome inequality: causes and consequences of non-random segregation errors in mitosis and meiosis. Cells 11(22):3564. https:\/\/doi.org\/10.3390\/cells11223564","journal-title":"Cells"},{"issue":"7919","key":"9735_CR82","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/s41586-022-04938-0","volume":"607","author":"SJ Klaasen","year":"2022","unstructured":"Klaasen SJ, Truong MA, van Jaarsveld RH, Koprivec I, \u0160timac V, de Vries SG, Risteski P, Kodba S, Vuku\u0161i\u0107 K, de Luca KL et al (2022) Nuclear chromosome locations dictate segregation error frequencies. Nature 607(7919):604\u2013609. https:\/\/doi.org\/10.1038\/s41586-022-04938-0","journal-title":"Nature"},{"key":"9735_CR83","doi-asserted-by":"publisher","unstructured":"Kneissig M, Keuper K, de Pagter MS, van Roosmalen MJ, Martin J, Otto H, Passerini V, Campos Sparr A, Renkens I, Kropveld F et al (2019) Micronuclei-based model system reveals functional consequences of chromothripsis in human cells. eLife 8. https:\/\/doi.org\/10.7554\/eLife.50292","DOI":"10.7554\/eLife.50292"},{"issue":"1","key":"9735_CR84","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1146\/annurev-cancerbio-042616-072231","volume":"1","author":"KA Knouse","year":"2017","unstructured":"Knouse KA, Davoli T, Elledge SJ, Amon A (2017) Aneuploidy in cancer: Seq-ing answers to old questions. Annu Rev Cancer Biol 1(1):335\u2013354. https:\/\/doi.org\/10.1146\/annurev-cancerbio-042616-072231","journal-title":"Annu Rev Cancer Biol"},{"issue":"37","key":"9735_CR85","doi-asserted-by":"publisher","first-page":"13409","DOI":"10.1073\/pnas.1415287111","volume":"111","author":"KA Knouse","year":"2014","unstructured":"Knouse KA, Wu J, Whittaker CA, Amon A (2014) Single cell sequencing reveals low levels of aneuploidy across mammalian tissues. Proc Natl Acad Sci 111(37):13409\u201313414. https:\/\/doi.org\/10.1073\/pnas.1415287111","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"9735_CR86","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1093\/dnares\/6.3.165","volume":"6","author":"H Kugoh","year":"1999","unstructured":"Kugoh H, Mitsuya K, Meguro M, Shigenami K, Schulz TC, Oshimura M (1999) Mouse A9 cells containing single human chromosomes for analysis of genomic imprinting. DNA Res 6(3):165\u2013172. https:\/\/doi.org\/10.1093\/dnares\/6.3.165","journal-title":"DNA Res"},{"issue":"1","key":"9735_CR87","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3390\/cancers8010004","volume":"8","author":"H Kugoh","year":"2016","unstructured":"Kugoh H, Ohira T, Oshimura M (2016) Studies of tumor suppressor genes via chromosome engineering. Cancers 8(1):4. https:\/\/doi.org\/10.3390\/cancers8010004","journal-title":"Cancers"},{"issue":"11","key":"9735_CR88","first-page":"1637","volume":"5","author":"HM Kugoh","year":"1990","unstructured":"Kugoh HM, Hashiba H, Shimizu M, Oshimura M (1990) Suggestive evidence for functionally distinct, tumor-suppressor genes on chromosomes 1 and 11 for a human fibrosarcoma cell line, HT1080. Oncogene 5(11):1637\u20131644","journal-title":"Oncogene"},{"issue":"3","key":"9735_CR89","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/ncb1102","volume":"6","author":"MA Lampson","year":"2004","unstructured":"Lampson MA, Renduchitala K, Khodjakov A, Kapoor TM (2004) Correcting improper chromosomes-spindle attachments during cell division. Nat Cell Biol 6(3):232\u2013237. https:\/\/doi.org\/10.1038\/ncb1102","journal-title":"Nat Cell Biol"},{"issue":"1","key":"9735_CR90","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13578-020-00452-w","volume":"10","author":"Y-FC Lau","year":"2020","unstructured":"Lau Y-FC (2020) Y chromosome in health and diseases. Cell Biosci 10(1):97. https:\/\/doi.org\/10.1186\/s13578-020-00452-w","journal-title":"Cell Biosci"},{"issue":"6","key":"9735_CR91","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s41588-021-00838-7","volume":"53","author":"ML Leibowitz","year":"2021","unstructured":"Leibowitz ML, Papathanasiou S, Doerfler PA, Blaine LJ, Sun L, Yao Y, Zhang CZ, Weiss MJ, Pellman D (2021) Chromothripsis as an on-target consequence of CRISPR\u2013Cas9 genome editing. Nat Genet 53(6):895\u2013905. https:\/\/doi.org\/10.1038\/s41588-021-00838-7","journal-title":"Nat Genet"},{"issue":"3","key":"9735_CR92","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.devcel.2016.12.022","volume":"40","author":"MS Levine","year":"2017","unstructured":"Levine MS, Bakker B, Boeckx B, Moyett J, Lu J, Vitre B, Spierings DC, Lansdorp PM, Cleveland DW, Lambrechts D, Foijer F, Holland AJ (2017) Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals. Dev Cell 40(3):313\u2013322.e5. https:\/\/doi.org\/10.1016\/j.devcel.2016.12.022","journal-title":"Dev Cell"},{"issue":"2","key":"9735_CR93","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/ng1097-223","volume":"17","author":"M Lewandoski","year":"1997","unstructured":"Lewandoski M, Martin GR (1997) Cre-mediated chromosome loss in mice. Nat Genet 17(2):223\u2013225. https:\/\/doi.org\/10.1038\/ng1097-223","journal-title":"Nat Genet"},{"issue":"5","key":"9735_CR94","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.stem.2012.08.004","volume":"11","author":"LB Li","year":"2012","unstructured":"Li LB, Chang KH, Wang PR, Hirata RK, Papayannopoulou T, Russell DW (2012) Trisomy correction in down syndrome induced pluripotent stem cells. Cell Stem Cell 11(5):615\u2013619. https:\/\/doi.org\/10.1016\/j.stem.2012.08.004","journal-title":"Cell Stem Cell"},{"issue":"6","key":"9735_CR95","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1083\/jcb.200904020","volume":"185","author":"M Li","year":"2009","unstructured":"Li M, Fang X, Wei Z, York JP, Zhang P (2009) Loss of spindle assembly checkpoint\u2013mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol 185(6):983\u2013994. https:\/\/doi.org\/10.1083\/jcb.200904020","journal-title":"J Cell Biol"},{"issue":"6","key":"9735_CR96","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1083\/jcb.201001006","volume":"188","author":"D Liu","year":"2010","unstructured":"Liu D, Vleugel M, Backer CB, Hori T, Fukagawa T, Cheeseman IM, Lampson MA (2010) Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. J Cell Biol 188(6):809\u2013820. https:\/\/doi.org\/10.1083\/jcb.201001006","journal-title":"J Cell Biol"},{"issue":"1","key":"9735_CR97","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/s41467-017-00528-1","volume":"8","author":"A Loda","year":"2017","unstructured":"Loda A, Brandsma JH, Vassilev I, Servant N, Loos F, Amirnasr A, Splinter E, Barillot E, Poot RA, Heard E, Gribnau J (2017) Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations. Nat Commun 8(1):690. https:\/\/doi.org\/10.1038\/s41467-017-00528-1","journal-title":"Nat Commun"},{"issue":"17","key":"9735_CR98","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1016\/J.DEVCEL.2021.07.009","volume":"56","author":"DA Lukow","year":"2021","unstructured":"Lukow DA, Sausville EL, Suri P, Chunduri NK, Wieland A, Leu J, Smith JC, Girish V, Kumar AA, Kendall J, Wang Z, Storchova Z, Sheltzer JM (2021) Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies. Dev Cell 56(17):2427\u20132439.e4. https:\/\/doi.org\/10.1016\/J.DEVCEL.2021.07.009","journal-title":"Dev Cell"},{"issue":"4","key":"9735_CR99","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/s41588-019-0360-8","volume":"51","author":"P Ly","year":"2019","unstructured":"Ly P, Brunner SF, Shoshani O, Kim DH, Lan W, Pyntikova T, Flanagan AM, Behjati S, Page DC, Campbell PJ, Cleveland DW (2019) Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nat Genet 51(4):705\u2013715. https:\/\/doi.org\/10.1038\/s41588-019-0360-8","journal-title":"Nat Genet"},{"issue":"1","key":"9735_CR100","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/ncb3450","volume":"19","author":"P Ly","year":"2017","unstructured":"Ly P, Teitz LS, Kim DH, Shoshani O, Skaletsky H, Fachinetti D, Page DC, Cleveland DW (2017) Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining. Nat Cell Biol 19(1):68\u201375. https:\/\/doi.org\/10.1038\/ncb3450","journal-title":"Nat Cell Biol"},{"issue":"12","key":"9735_CR101","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1038\/s41416-018-0081-2","volume":"118","author":"ARR Maia","year":"2018","unstructured":"Maia ARR, Linder S, Song J-Y, Vaarting C, Boon U, Pritchard CEJ, Velds A, Huijbers IJ, van Tellingen O, Jonkers J, Medema RH (2018) Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division. Br J Cancer 118(12):1586\u20131595. https:\/\/doi.org\/10.1038\/s41416-018-0081-2","journal-title":"Br J Cancer"},{"issue":"2","key":"9735_CR102","doi-asserted-by":"publisher","first-page":"e202101210","DOI":"10.26508\/lsa.202101210","volume":"5","author":"AE Mammel","year":"2022","unstructured":"Mammel AE, Huang HZ, Gunn AL, Choo E, Hatch EM (2022) Chromosome length and gene density contribute to micronuclear membrane stability. Life Sci Alliance 5(2):e202101210. https:\/\/doi.org\/10.26508\/lsa.202101210","journal-title":"Life Sci Alliance"},{"issue":"23","key":"9735_CR103","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1038\/sj.onc.1201461","volume":"15","author":"T Matsuda","year":"1997","unstructured":"Matsuda T, Sasaki M, Kato H, Yamada H, Cohen M, Barrett JC, Oshimura M, Wake N (1997) Human chromosome 7 carries a putative tumor suppressor gene(s) involved in choriocarcinoma. Oncogene 15(23):2773\u20132781. https:\/\/doi.org\/10.1038\/sj.onc.1201461","journal-title":"Oncogene"},{"issue":"1","key":"9735_CR104","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/nmeth973","volume":"4","author":"H Matsumura","year":"2007","unstructured":"Matsumura H, Tada M, Otsuji T, Yasuchika K, Nakatsuji N, Surani A, Tada T (2007) Targeted chromosome elimination from ES-somatic hybrid cells. Nat Methods 4(1):23\u201325. https:\/\/doi.org\/10.1038\/nmeth973","journal-title":"Nat Methods"},{"issue":"5441","key":"9735_CR105","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1126\/science.286.5441.971","volume":"286","author":"TU Mayer","year":"1999","unstructured":"Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ (1999) Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286(5441):971\u2013974. https:\/\/doi.org\/10.1126\/science.286.5441.971","journal-title":"Science"},{"issue":"4","key":"9735_CR106","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00412-005-0014-8","volume":"114","author":"KJ Meaburn","year":"2005","unstructured":"Meaburn KJ, Parris CN, Bridger JM (2005) The manipulation of chromosomes by mankind: the uses of microcell-mediated chromosome transfer. Chromosoma 114(4):263\u2013274. https:\/\/doi.org\/10.1007\/s00412-005-0014-8","journal-title":"Chromosoma"},{"issue":"10","key":"9735_CR107","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.15252\/embj.201490070","volume":"34","author":"JK Meena","year":"2015","unstructured":"Meena JK, Cerutti A, Beichler C, Morita Y, Bruhn C, Kumar M, Kraus JM, Speicher MR, Wang Z-Q, Kestler HA, d\u2019Adda di Fagagna F, G\u00fcnes C, Rudolph KL (2015) Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion. EMBO J 34(10):1371\u20131384. https:\/\/doi.org\/10.15252\/embj.201490070","journal-title":"EMBO J"},{"issue":"6818","key":"9735_CR108","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/35053094","volume":"409","author":"LS Michel","year":"2001","unstructured":"Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, Dobles M, Sorger PK, Murty VV, Benezra R (2001) MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409(6818):355\u2013359. https:\/\/doi.org\/10.1038\/35053094","journal-title":"Nature"},{"issue":"3","key":"9735_CR109","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.cell.2018.02.020","volume":"173","author":"TJ Mitchell","year":"2018","unstructured":"Mitchell TJ, Turajlic S, Rowan A, Nicol D, Farmery JHR, O\u2019Brien T, Martincorena I, Tarpey P, Angelopoulos N, Yates LR et al (2018) Timing the landmark events in the evolution of clear cell renal cell cancer: TRACERx renal. Cell 173(3):611\u2013623.e17. https:\/\/doi.org\/10.1016\/j.cell.2018.02.020","journal-title":"Cell"},{"issue":"2","key":"9735_CR110","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/1574-6976.12048","volume":"38","author":"W Mulla","year":"2014","unstructured":"Mulla W, Zhu J, Li R (2014) Yeast: A simple model system to study complex phenomena of aneuploidy. FEMS Microbiol Rev 38(2):201\u2013212. https:\/\/doi.org\/10.1111\/1574-6976.12048","journal-title":"FEMS Microbiol Rev"},{"issue":"5","key":"9735_CR111","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nrm2163","volume":"8","author":"A Musacchio","year":"2007","unstructured":"Musacchio A, Salmon ED (2007) The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 8(5):379\u2013393. https:\/\/doi.org\/10.1038\/nrm2163","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9735_CR112","doi-asserted-by":"publisher","first-page":"693154","DOI":"10.3389\/fcell.2021.693154","volume":"9","author":"I Naciri","year":"2021","unstructured":"Naciri I, Lin B, Webb C-H, Jiang S, Carmona S, Liu W, Mortazavi A, Sun S (2021) Linking chromosomal silencing with Xist expression from autosomal integrated transgenes. Front Cell Dev Biol 9:693154","journal-title":"Front Cell Dev Biol"},{"issue":"12","key":"9735_CR113","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1038\/s41587-022-01377-0","volume":"40","author":"AD Nahmad","year":"2022","unstructured":"Nahmad AD, Reuveni E, Goldschmidt E, Tenne T, Liberman M, Horovitz-Fried M, Khosravi R, Kobo H, Reinstein E, Madi A, Ben-David U, Barzel A (2022) Frequent aneuploidy in primary human T cells after CRISPR\u2013Cas9 cleavage. Nat Biotechnol 40(12):1807\u20131813. https:\/\/doi.org\/10.1038\/s41587-022-01377-0","journal-title":"Nat Biotechnol"},{"issue":"1","key":"9735_CR114","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1247\/csf.14005","volume":"40","author":"Y Nakayama","year":"2015","unstructured":"Nakayama Y, Uno N, Uno K, Mizoguchi Y, Komoto S, Kazuki Y, Nanba E, Inoue T, Oshimura M (2015) Recurrent micronucleation through cell cycle progression in the presence of microtubule inhibitors. Cell Struct Funct 40(1):51\u201359. https:\/\/doi.org\/10.1247\/csf.14005","journal-title":"Cell Struct Funct"},{"issue":"530","key":"9735_CR115","doi-asserted-by":"publisher","first-page":"eaai8669","DOI":"10.1126\/scisignal.aai8669","volume":"11","author":"I Nasa","year":"2018","unstructured":"Nasa I, Rusin SF, Kettenbach AN, Moorhead GB (2018) Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins. Sci Signal 11(530):eaai8669. https:\/\/doi.org\/10.1126\/scisignal.aai8669","journal-title":"Sci Signal"},{"issue":"9","key":"9735_CR116","doi-asserted-by":"publisher","first-page":"e25319","DOI":"10.1371\/journal.pone.0025319","volume":"6","author":"H Nawata","year":"2011","unstructured":"Nawata H, Kashino G, Tano K, Daino K, Shimada Y, Kugoh H, Oshimura M, Watanabe M (2011) Dysregulation of gene expression in the artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes. PLoS One 6(9):e25319. https:\/\/doi.org\/10.1371\/journal.pone.0025319","journal-title":"PLoS One"},{"key":"9735_CR117","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.05068","volume":"4","author":"JM Nicholson","year":"2015","unstructured":"Nicholson JM, Macedo JC, Mattingly AJ, Wangsa D, Camps J, Lima V, Gomes AM, D\u00f3ria S, Ried T, Logarinho E, Cimini D (2015) Chromosome mis-segregation and cytokinesis failure in trisomic human cells. eLife 4:1\u201323. https:\/\/doi.org\/10.7554\/eLife.05068","journal-title":"eLife"},{"issue":"12","key":"9735_CR118","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1038\/ncb3065","volume":"16","author":"W Nijenhuis","year":"2014","unstructured":"Nijenhuis W, Vallardi G, Teixeira A, Kops GJPL, Saurin AT (2014) Negative feedback at kinetochores underlies a responsive spindle checkpoint signal. Nat Cell Biol 16(12):1257\u20131264. https:\/\/doi.org\/10.1038\/ncb3065","journal-title":"Nat Cell Biol"},{"key":"9735_CR119","doi-asserted-by":"publisher","unstructured":"Nijenhuis W, van Grinsven MMP, Kapitein LC (2020) An optimized toolbox for the optogenetic control of intracellular transport. J Cell Biol 219(4). https:\/\/doi.org\/10.1083\/jcb.201907149","DOI":"10.1083\/jcb.201907149"},{"issue":"4","key":"9735_CR120","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.bbrc.2015.09.119","volume":"466","author":"S Nishio","year":"2015","unstructured":"Nishio S, Ohira T, Sunamura N, Oshimura M, Ryoke K, Kugoh H (2015) Repression of hTERT transcription by the introduction of chromosome 3 into human oral squamous cell carcinoma. Biochem Biophys Res Commun 466(4):755\u2013759. https:\/\/doi.org\/10.1016\/j.bbrc.2015.09.119","journal-title":"Biochem Biophys Res Commun"},{"issue":"25","key":"9735_CR121","doi-asserted-by":"publisher","first-page":"16226","DOI":"10.1073\/pnas.202617399","volume":"99","author":"MA Nowak","year":"2002","unstructured":"Nowak MA, Komarova NL, Sengupta A, Jallepalli PV, Shih I-M, Vogelstein B, Lengauer C (2002) The role of chromosomal instability in tumor initiation. Proc Natl Acad Sci 99(25):16226\u201316231. https:\/\/doi.org\/10.1073\/pnas.202617399","journal-title":"Proc Natl Acad Sci"},{"issue":"6588","key":"9735_CR122","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1126\/science.abj6987","volume":"376","author":"S Nurk","year":"2022","unstructured":"Nurk S, Koren S, Rhie A, Rautiainen M, Bzikadze AV, Mikheenko A, Vollger MR, Altemose N, Uralsky L, Gershman A et al (2022) The complete sequence of a human genome. Science 376(6588):44\u201353. https:\/\/doi.org\/10.1126\/science.abj6987","journal-title":"Science"},{"issue":"5743","key":"9735_CR123","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1126\/science.1114535","volume":"309","author":"A O\u2019Doherty","year":"2005","unstructured":"O\u2019Doherty A, Ruf S, Mulligan C, Hildreth V, Errington ML, Cooke S, Sesay A, Modino S, Vanes L, Hernandez D, Linehan JM, Sharpe PT, Brandner S, Bliss TVP, Henderson DJ, Nizetic D, Tybulewicz VLJ, Fisher EMC (2005) An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science 309(5743):2033\u20132037. https:\/\/doi.org\/10.1126\/science.1114535","journal-title":"Science"},{"issue":"10","key":"9735_CR124","doi-asserted-by":"publisher","first-page":"6036","DOI":"10.1128\/mcb.13.10.6036-6043.1993","volume":"13","author":"T Ogata","year":"1993","unstructured":"Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M (1993) Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1. Mol Cell Biol 13(10):6036\u20136043. https:\/\/doi.org\/10.1128\/mcb.13.10.6036-6043.1993","journal-title":"Mol Cell Biol"},{"issue":"1","key":"9735_CR125","doi-asserted-by":"publisher","first-page":"7668","DOI":"10.1038\/ncomms8668","volume":"6","author":"A Ohashi","year":"2015","unstructured":"Ohashi A, Ohori M, Iwai K, Nakayama Y, Nambu T, Morishita D, Kawamoto T, Miyamoto M, Hirayama T, Okaniwa M, Banno H, Ishikawa T, Kandori H, Iwata K (2015) Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells. Nat Commun 6(1):7668. https:\/\/doi.org\/10.1038\/ncomms8668","journal-title":"Nat Commun"},{"issue":"10","key":"9735_CR126","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1111\/j.1349-7006.1995.tb02998.x","volume":"86","author":"H Ohmura","year":"1995","unstructured":"Ohmura H, Tahara H, Suzuki M, Ide T, Shimizu M, Yoshida MA, Tahara E, Shay JW, Barrett JC, Oshimura M (1995) Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. Jpn J Cancer Res 86(10):899\u2013904. https:\/\/doi.org\/10.1111\/j.1349-7006.1995.tb02998.x","journal-title":"Jpn J Cancer Res"},{"key":"9735_CR127","doi-asserted-by":"publisher","unstructured":"Oldak B, Wildschutz E, Bondarenko V, Aguilera-Castrejon A, Zhao C, Tarazi S, Comar M-Y, Ashouokhi S, Lokshtanov D, Roncato F (2023) Transgene-free Ex utero derivation of a human post-implantation embryo model solely from genetically unmodified na\u00efve PSCs. BioRxiv. https:\/\/doi.org\/10.1101\/2023.06.14.544922","DOI":"10.1101\/2023.06.14.544922"},{"key":"9735_CR128","first-page":"249","volume":"20","author":"M Oshimura","year":"1989","unstructured":"Oshimura M, Kugoh HM, Shimizu M, Yamada H, Hashiba H, Horikawa I, Sasaki M (1989) Multiple chromosomes carrying tumor suppressor activity, via microcell-mediated chromosome transfer, for various tumor cell lines. Princess Takamatsu Symp 20:249\u2013257","journal-title":"Princess Takamatsu Symp"},{"issue":"2","key":"9735_CR129","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.jmb.2008.01.065","volume":"378","author":"T Otsuji","year":"2008","unstructured":"Otsuji T, Matsumura H, Suzuki T, Nakatsuji N, Tada T, Tada M (2008) Rapid induction of large chromosomal deletions by a Cre\/inverted loxP system in mouse ES cell hybrids. J Mol Biol 378(2):328\u2013336. https:\/\/doi.org\/10.1016\/j.jmb.2008.01.065","journal-title":"J Mol Biol"},{"issue":"1","key":"9735_CR130","doi-asserted-by":"publisher","first-page":"5855","DOI":"10.1038\/s41467-021-26097-y","volume":"12","author":"S Papathanasiou","year":"2021","unstructured":"Papathanasiou S, Markoulaki S, Blaine LJ, Leibowitz ML, Zhang CZ, Jaenisch R, Pellman D (2021) Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing. Nat Commun 12(1):5855. https:\/\/doi.org\/10.1038\/s41467-021-26097-y","journal-title":"Nat Commun"},{"issue":"5866","key":"9735_CR131","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/297474a0","volume":"297","author":"LF Parada","year":"1982","unstructured":"Parada LF, Tabin CJ, Shih C, Weinberg RA (1982) Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature 297(5866):474\u2013478. https:\/\/doi.org\/10.1038\/297474a0","journal-title":"Nature"},{"key":"9735_CR132","doi-asserted-by":"publisher","first-page":"10754","DOI":"10.1038\/ncomms10754","volume":"7","author":"V Passerini","year":"2016","unstructured":"Passerini V, Ozeri-Galai E, de Pagter MS, Donnelly N, Schmalbrock S, Kloosterman WP, Kerem B, Storchov\u00e1 Z (2016) The presence of extra chromosomes leads to genomic instability. Nat Commun 7:10754. https:\/\/doi.org\/10.1038\/ncomms10754","journal-title":"Nat Commun"},{"issue":"6190","key":"9735_CR133","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1126\/science.1254257","volume":"344","author":"AP Patel","year":"2014","unstructured":"Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, Cahill DP, Nahed BV, Curry WT, Martuza RL et al (2014) Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science 344(6190):1396\u20131401. https:\/\/doi.org\/10.1126\/science.1254257","journal-title":"Science"},{"issue":"1","key":"9735_CR134","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13073-021-00905-Y","volume":"13","author":"S Patkar","year":"2021","unstructured":"Patkar S, Heselmeyer-Haddad K, Auslander N, Hirsch D, Camps J, Bronder D, Brown M, Chen W-D, Lokanga R, Wangsa D et al (2021) Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies. Genome Med 13(1):1\u201316. https:\/\/doi.org\/10.1186\/S13073-021-00905-Y","journal-title":"Genome Med"},{"issue":"7321","key":"9735_CR135","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nature09529","volume":"468","author":"N Pavelka","year":"2010","unstructured":"Pavelka N, Rancati G, Zhu J, Bradford WD, Saraf A, Florens L, Sanderson BW, Hattem GL, Li R (2010) Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature 468(7321):321\u2013325. https:\/\/doi.org\/10.1038\/nature09529","journal-title":"Nature"},{"issue":"22","key":"9735_CR136","doi-asserted-by":"publisher","first-page":"8143","DOI":"10.1158\/0008-5472.can-04-0474","volume":"61","author":"JL Phillips","year":"2001","unstructured":"Phillips JL, Hayward SW, Wang Y, Vasselli J, Pavlovich C, Padilla-Nash H, Pezullo JR, Ghadimi BM, Grossfeld GD, Rivera A, Linehan WM, Cunha GR, Ried T (2001) The consequences of chromosomal aneuploidy on gene expression profiles in a cell line model for prostate carcinogenesis. Cancer Res 61(22):8143\u20138149. https:\/\/doi.org\/10.1158\/0008-5472.can-04-0474","journal-title":"Cancer Res"},{"issue":"14","key":"9735_CR137","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1016\/j.cell.2023.06.006","volume":"186","author":"M Qi","year":"2023","unstructured":"Qi M, Pang J, Mitsiades I, Lane AA, Rheinbay E (2023) Loss of chromosome Y in primary tumors. Cell 186(14):3125\u20133136.e11. https:\/\/doi.org\/10.1016\/j.cell.2023.06.006","journal-title":"Cell"},{"issue":"9","key":"9735_CR138","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/nrc1165","volume":"3","author":"H Rajagopalan","year":"2003","unstructured":"Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C (2003) The significance of unstable chromosomes in colorectal cancer. Nat Rev Cancer 3(9):695\u2013701. https:\/\/doi.org\/10.1038\/nrc1165","journal-title":"Nat Rev Cancer"},{"issue":"23\u201324","key":"9735_CR139","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1101\/GAD.319400.118","volume":"32","author":"MC Ravichandran","year":"2018","unstructured":"Ravichandran MC, Fink S, Clarke MN, Hofer FC, Campbell CS (2018) Genetic interactions between specific chromosome copy number alterations dictate complex aneuploidy patterns. Genes Dev 32(23\u201324):1485\u20131498. https:\/\/doi.org\/10.1101\/GAD.319400.118","journal-title":"Genes Dev"},{"issue":"3","key":"9735_CR140","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/BF00284772","volume":"41","author":"VM Riccardi","year":"1978","unstructured":"Riccardi VM, Crandall BF (1978) Karyotype-phenotype correlation: mosaic trisomy 8 and partial trisomies of different segments of chromosome 8. Hum Genet 41(3):363\u2013367. https:\/\/doi.org\/10.1007\/BF00284772","journal-title":"Hum Genet"},{"issue":"2","key":"9735_CR141","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/jmor.1050270202","volume":"27","author":"WMRB Robertson","year":"1916","unstructured":"Robertson WMRB (1916) Taxonomic relationships shown in the chromosomes of tettigidae and acrididae: V-shaped chromosomes and their significance in acrididae, locustidae, and gryllidae: chromosomes and variation. J Morphol 27(2):179\u2013331. https:\/\/doi.org\/10.1002\/jmor.1050270202","journal-title":"J Morphol"},{"issue":"1","key":"9735_CR142","doi-asserted-by":"publisher","first-page":"22828","DOI":"10.1038\/srep22828","volume":"6","author":"SD Rutledge","year":"2016","unstructured":"Rutledge SD, Douglas TA, Nicholson JM, Vila-Casades\u00fas M, Kantzler CL, Wangsa D, Barroso-Vilares M, Kale SD, Logarinho E, Cimini D (2016) Selective advantage of trisomic human cells cultured in non-standard conditions. Sci Rep 6(1):22828. https:\/\/doi.org\/10.1038\/srep22828","journal-title":"Sci Rep"},{"issue":"2","key":"9735_CR143","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.cell.2018.02.037","volume":"173","author":"LM Sack","year":"2018","unstructured":"Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong K-K, Elledge SJ (2018) Profound tissue specificity in proliferation control underlies cancer drivers and aneuploidy patterns. Cell 173(2):499\u2013514.e23. https:\/\/doi.org\/10.1016\/j.cell.2018.02.037","journal-title":"Cell"},{"issue":"1","key":"9735_CR144","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/gim.2016.69","volume":"19","author":"T Sahoo","year":"2017","unstructured":"Sahoo T, Dzidic N, Strecker MN, Commander S, Travis MK, Doherty C, Tyson RW, Mendoza AE, Stephenson M, Dise CA, Benito CW, Ziadie MS, Hovanes K (2017) Comprehensive genetic analysis of pregnancy loss by chromosomal microarrays: outcomes, benefits, and challenges. Genet Med 19(1):83\u201389. https:\/\/doi.org\/10.1038\/gim.2016.69","journal-title":"Genet Med"},{"issue":"6603","key":"9735_CR145","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1126\/science.abn3100","volume":"377","author":"S Sano","year":"2022","unstructured":"Sano S, Horitani K, Ogawa H, Halvardson J, Chavkin NW, Wang Y, Sano M, Mattisson J, Hata A, Danielsson M et al (2022) Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality. Science 377(6603):292\u2013297. https:\/\/doi.org\/10.1126\/science.abn3100","journal-title":"Science"},{"issue":"3","key":"9735_CR146","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/nrclinonc.2017.198","volume":"15","author":"L Sansregret","year":"2018","unstructured":"Sansregret L, Vanhaesebroeck B, Swanton C (2018) Determinants and clinical implications of chromosomal instability in cancer. Nat Rev Clin Oncol 15(3):139\u2013150. https:\/\/doi.org\/10.1038\/nrclinonc.2017.198","journal-title":"Nat Rev Clin Oncol"},{"issue":"6","key":"9735_CR147","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/J.DEVCEL.2017.05.022","volume":"41","author":"S Santaguida","year":"2017","unstructured":"Santaguida S, Richardson A, Iyer DR, M\u2019Saad O, Zasadil L, Knouse KA, Wong YL, Rhind N, Desai A, Amon A (2017) Chromosome mis-segregation generates cell-cycle-arrested cells with complex karyotypes that are eliminated by the immune system. Dev Cell 41(6):638\u2013651.e5. https:\/\/doi.org\/10.1016\/J.DEVCEL.2017.05.022","journal-title":"Dev Cell"},{"issue":"1","key":"9735_CR148","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1083\/jcb.201001036","volume":"190","author":"S Santaguida","year":"2010","unstructured":"Santaguida S, Tighe A, D\u2019Alise AM, Taylor SS, Musacchio A (2010) Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J Cell Biol 190(1):73\u201387. https:\/\/doi.org\/10.1083\/jcb.201001036","journal-title":"J Cell Biol"},{"issue":"19","key":"9735_CR149","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1101\/gad.269118.115","volume":"29","author":"S Santaguida","year":"2015","unstructured":"Santaguida S, Vasile E, White E, Amon A (2015) Aneuploidy-induced cellular stresses limit autophagic degradation. Genes Dev 29(19):2010\u20132021. https:\/\/doi.org\/10.1101\/gad.269118.115","journal-title":"Genes Dev"},{"key":"9735_CR150","doi-asserted-by":"publisher","first-page":"6037159","DOI":"10.1155\/2017\/6037159","volume":"2017","author":"H Sato","year":"2017","unstructured":"Sato H, Kato H, Yamaza H, Masuda K, Nguyen HTN, Pham TTM, Han X, Hirofuji Y, Nonaka K (2017) Engineering of systematic elimination of a targeted chromosome in human cells. BioMed Res Int 2017:6037159. https:\/\/doi.org\/10.1155\/2017\/6037159","journal-title":"BioMed Res Int"},{"issue":"14","key":"9735_CR151","doi-asserted-by":"publisher","first-page":"5166","DOI":"10.1073\/pnas.85.14.5166","volume":"85","author":"B Sauer","year":"1988","unstructured":"Sauer B, Henderson N (1988) Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc Natl Acad Sci U S A 85(14):5166\u20135170. https:\/\/doi.org\/10.1073\/pnas.85.14.5166","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"9735_CR152","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.1002\/j.1460-2075.1986.tb04670.x","volume":"5","author":"PJ Saxon","year":"1986","unstructured":"Saxon PJ, Srivatsan ES, Stanbridge EJ (1986) Introduction of human chromosome 11 via microcell transfer controls tumorigenic expression of HeLa cells. EMBO J 5(13):3461\u20133466. https:\/\/doi.org\/10.1002\/j.1460-2075.1986.tb04670.x","journal-title":"EMBO J"},{"issue":"2","key":"9735_CR153","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/nrc2781","volume":"10","author":"J-M Schvartzman","year":"2010","unstructured":"Schvartzman J-M, Sotillo R, Benezra R (2010) Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer 10(2):102\u2013115. https:\/\/doi.org\/10.1038\/nrc2781","journal-title":"Nat Rev Cancer"},{"issue":"11","key":"9735_CR154","first-page":"2764","volume":"60","author":"MJ Seraj","year":"2000","unstructured":"Seraj MJ, Samant RS, Verderame MF, Welch DR (2000) Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q131. Cancer Res 60(11):2764\u20132769","journal-title":"Cancer Res"},{"issue":"6444","key":"9735_CR155","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1126\/science.aax0164","volume":"364","author":"MN Shahbazi","year":"2019","unstructured":"Shahbazi MN, Siggia ED, Zernicka-Goetz M (2019) Self-organization of stem cells into embryos: a window on early mammalian development. Science 364(6444):948\u2013951. https:\/\/doi.org\/10.1126\/science.aax0164","journal-title":"Science"},{"issue":"2","key":"9735_CR156","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/J.CCELL.2016.12.004","volume":"31","author":"JM Sheltzer","year":"2017","unstructured":"Sheltzer JM, Ko JH, Replogle JM, Habibe Burgos NC, Chung ES, Meehl CM, Sayles NM, Passerini V, Storchova Z, Amon A (2017) Single-chromosome gains commonly function as tumor suppressors. Cancer Cell 31(2):240\u2013255. https:\/\/doi.org\/10.1016\/J.CCELL.2016.12.004","journal-title":"Cancer Cell"},{"key":"9735_CR157","doi-asserted-by":"publisher","unstructured":"Shih J, Sarmashghi S, Zhakula-Kostadinova N, Zhang S, Georgis Y, Hoyt SH, Cuoco MS, Gao GF, Spurr LF, Berger AC, Ha G, Rendo V, Shen H, Meyerson M, Cherniack AD, Taylor AM, Beroukhim R (2023) Cancer aneuploidies are shaped primarily by effects on tumour fitness. Nature. https:\/\/doi.org\/10.1038\/s41586-023-06266-3","DOI":"10.1038\/s41586-023-06266-3"},{"issue":"11","key":"9735_CR158","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1093\/hmg\/10.11.1163","volume":"10","author":"T Shinohara","year":"2001","unstructured":"Shinohara T, Tomizuka K, Miyabara S, Takehara S, Kazuki Y, Inoue J, Katoh M, Nakane H, Iino A, Ohguma A, Ikegami S, Inokuchi K, Ishida I, Reeves RH, Oshimura M (2001) Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down\u2019s syndrome. Hum Mol Genet 10(11):1163\u20131175. https:\/\/doi.org\/10.1093\/hmg\/10.11.1163","journal-title":"Hum Mol Genet"},{"issue":"15\u201316","key":"9735_CR159","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1101\/gad.348319.121","volume":"35","author":"O Shoshani","year":"2021","unstructured":"Shoshani O, Bakker B, de Haan L, Tijhuis AE, Wang Y, Kim DH, Maldonado M, Demarest MA, Artates J, Zhengyu O et al (2021a) Transient genomic instability drives tumorigenesis through accelerated clonal evolution. Genes Dev 35(15\u201316):1093\u20131108. https:\/\/doi.org\/10.1101\/gad.348319.121","journal-title":"Genes Dev"},{"issue":"7848","key":"9735_CR160","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41586-020-03064-z","volume":"591","author":"O Shoshani","year":"2021","unstructured":"Shoshani O, Brunner SF, Yaeger R, Ly P, Nechemia-Arbely Y, Kim DH, Fang R, Castillon GA, Yu M, Li JSZ, Sun Y, Ellisman MH, Ren B, Campbell PJ, Cleveland DW (2021b) Chromothripsis drives the evolution of gene amplification in cancer. Nature 591(7848):137\u2013141. https:\/\/doi.org\/10.1038\/s41586-020-03064-z","journal-title":"Nature"},{"key":"9735_CR161","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/978-3-319-20291-4_2","volume":"200","author":"JE Simon","year":"2015","unstructured":"Simon JE, Bakker B, Foijer F (2015) CINcere modelling: what have mouse models for chromosome instability taught us? Recent Results Cancer Res 200:39\u201360. https:\/\/doi.org\/10.1007\/978-3-319-20291-4_2","journal-title":"Recent Results Cancer Res"},{"issue":"7480","key":"9735_CR162","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nature12719","volume":"504","author":"MD Simon","year":"2013","unstructured":"Simon MD, Pinter SF, Fang R, Sarma K, Rutenberg-Schoenberg M, Bowman SK, Kesner BA, Maier VK, Kingston RE, Lee JT (2013) High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation. Nature 504(7480):465\u2013469. https:\/\/doi.org\/10.1038\/nature12719","journal-title":"Nature"},{"issue":"1","key":"9735_CR163","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ccr.2006.10.019","volume":"11","author":"R Sotillo","year":"2007","unstructured":"Sotillo R, Hernando E, D\u00edaz-Rodr\u00edguez E, Teruya-Feldstein J, Cord\u00f3n-Cardo C, Lowe SW, Benezra R (2007) Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 11(1):9\u201323. https:\/\/doi.org\/10.1016\/j.ccr.2006.10.019","journal-title":"Cancer Cell"},{"issue":"12","key":"9735_CR164","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1016\/J.CELREP.2017.05.055","volume":"19","author":"M Soto","year":"2017","unstructured":"Soto M, Raaijmakers JA, Bakker B, Spierings DCJ, Lansdorp PM, Foijer F, Medema RH (2017) p53 prohibits propagation of chromosome segregation errors that produce structural aneuploidies. Cell Rep 19(12):2423\u20132431. https:\/\/doi.org\/10.1016\/J.CELREP.2017.05.055","journal-title":"Cell Rep"},{"issue":"1","key":"9735_CR165","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cell.2010.11.055","volume":"144","author":"PJ Stephens","year":"2011","unstructured":"Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, Pleasance ED, Lau KW, Beare D, Stebbings LA et al (2011) Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 144(1):27\u201340. https:\/\/doi.org\/10.1016\/j.cell.2010.11.055","journal-title":"Cell"},{"issue":"4","key":"9735_CR166","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/0022-2836(81)90375-2","volume":"150","author":"N Sternberg","year":"1981","unstructured":"Sternberg N, Hamilton D (1981) Bacteriophage P1 site-specific recombination: I. Recombination between loxP sites. J Mol Biol 150(4):467\u2013486. https:\/\/doi.org\/10.1016\/0022-2836(81)90375-2","journal-title":"J Mol Biol"},{"issue":"1","key":"9735_CR167","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/msb.2012.40","volume":"8","author":"S Stingele","year":"2012","unstructured":"Stingele S, Stoehr G, Peplowska K, Cox J, Mann M, Storchova Z (2012) Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells. Mol Syst Biol 8(1):608. https:\/\/doi.org\/10.1038\/msb.2012.40","journal-title":"Mol Syst Biol"},{"issue":"78","key":"9735_CR168","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1101\/gad.345454.120","volume":"35","author":"XA Su","year":"2021","unstructured":"Su XA, Ma D, Parsons JV, Replogle JM, Amatruda JF, Whittaker CA, Stegmaier K, Amon A (2021) RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress. Genes Dev 35(78):556\u2013572. https:\/\/doi.org\/10.1101\/gad.345454.120","journal-title":"Genes Dev"},{"issue":"4","key":"9735_CR169","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s10577-009-9035-0","volume":"17","author":"M Tada","year":"2009","unstructured":"Tada M, Matsumura H, Kurose Y, Nakatsuji N, Tada T (2009) Target chromosomes of inducible deletion by a Cre\/inverted loxP system in mouse embryonic stem cells. Chromosome Res 17(4):443\u2013450. https:\/\/doi.org\/10.1007\/s10577-009-9035-0","journal-title":"Chromosome Res"},{"issue":"4","key":"9735_CR170","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1023\/a:1009283529392","volume":"8","author":"H Tanabe","year":"2000","unstructured":"Tanabe H, Nakagawa Y, Minegishi D, Hashimoto K, Tanaka N, Oshimura M, Sofuni T, Mizusawa H (2000) Human monochromosome hybrid cell panel characterized by FISH in the JCRB\/HSRRB. Chromosome Res 8(4):319\u2013334. https:\/\/doi.org\/10.1023\/a:1009283529392","journal-title":"Chromosome Res"},{"issue":"2","key":"9735_CR171","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/(SICI)1098-2264(199810)23:2<123::AID-GCC5>3.0.CO;2-4","volume":"23","author":"H Tanaka","year":"1998","unstructured":"Tanaka H, Shimizu M, Horikawa I, Kugoh H, Yokota J, Barrett JC, Oshimura M (1998) Evidence for a putative telomerase repressor gene in the 3p14.2\u2013p21.1 region. Genes Chromosomes Cancer 23(2):123\u2013133","journal-title":"Genes Chromosomes Cancer"},{"issue":"4","key":"9735_CR172","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/J.CCELL.2018.03.007","volume":"33","author":"AM Taylor","year":"2018","unstructured":"Taylor AM, Shih J, Ha G, Gao GF, Zhang X, Berger AC, Schumacher SE, Wang C, Hu H, Liu J et al (2018) Genomic and functional approaches to understanding cancer aneuploidy. Cancer Cell 33(4):676\u2013689.e3. https:\/\/doi.org\/10.1016\/J.CCELL.2018.03.007","journal-title":"Cancer Cell"},{"issue":"4","key":"9735_CR173","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1093\/humupd\/dmu016","volume":"20","author":"TH Taylor","year":"2014","unstructured":"Taylor TH, Gitlin SA, Patrick JL, Crain JL, Wilson JM, Griffin DK (2014) The origin, mechanisms, incidence and clinical consequences of chromosomal mosaicism in humans. Hum Reprod Update 20(4):571\u2013581. https:\/\/doi.org\/10.1093\/humupd\/dmu016","journal-title":"Hum Reprod Update"},{"issue":"2","key":"9735_CR174","doi-asserted-by":"publisher","first-page":"201","DOI":"10.15252\/embj.201797630","volume":"37","author":"R Thomas","year":"2018","unstructured":"Thomas R, Marks DH, Chin Y, Benezra R (2018) Whole chromosome loss and associated breakage\u2013fusion\u2013bridge cycles transform mouse tetraploid cells. EMBO J 37(2):201\u2013218. https:\/\/doi.org\/10.15252\/embj.201797630","journal-title":"EMBO J"},{"issue":"7784","key":"9735_CR175","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/s41586-019-1765-3","volume":"575","author":"DJ Thompson","year":"2019","unstructured":"Thompson DJ, Genovese G, Halvardson J, Ulirsch JC, Wright DJ, Terao C, Davidsson OB, Day FR, Sulem P, Jiang Y et al (2019) Genetic predisposition to mosaic Y chromosome loss in blood. Nature 575(7784):652\u2013657. https:\/\/doi.org\/10.1038\/s41586-019-1765-3","journal-title":"Nature"},{"issue":"1","key":"9735_CR176","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13039-019-0429-1","volume":"12","author":"AE Tijhuis","year":"2019","unstructured":"Tijhuis AE, Johnson SC, McClelland SE (2019) The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity. Mol Cytogenet 12(1):1\u201321. https:\/\/doi.org\/10.1186\/s13039-019-0429-1","journal-title":"Mol Cytogenet"},{"issue":"5840","key":"9735_CR177","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1126\/science.1142210","volume":"317","author":"EM Torres","year":"2007","unstructured":"Torres EM, Sokolsky T, Tucker CM, Chan LY, Boselli M, Dunham MJ, Amon A (2007) Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science 317(5840):916\u2013924. https:\/\/doi.org\/10.1126\/science.1142210","journal-title":"Science"},{"key":"9735_CR178","doi-asserted-by":"publisher","first-page":"e111587","DOI":"10.15252\/embj.2022111587","volume":"42","author":"L Tovini","year":"2023","unstructured":"Tovini L, Johnson SC, Guscott MA, Andersen AM, Spierings DCJ, Wardenaar R, Foijer F, McClelland SE (2023) Targeted assembly of ectopic kinetochores to induce chromosome-specific segmental aneuploidies. EMBO J 42:e111587. https:\/\/doi.org\/10.15252\/embj.2022111587","journal-title":"EMBO J"},{"issue":"2","key":"9735_CR179","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3390\/BIOM9020044","volume":"9","author":"L Tovini","year":"2019","unstructured":"Tovini L, McClelland SE (2019) Impaired CENP-E function renders large chromosomes more vulnerable to congression failure. Biomol 9(2):44. https:\/\/doi.org\/10.3390\/BIOM9020044","journal-title":"Biomol"},{"key":"9735_CR180","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1101\/gad.348341.121","volume":"35","author":"M Trakala","year":"2021","unstructured":"Trakala M, Aggarwal M, Sniffen C, Zasadil L, Carroll A, Ma D, Su XA, Wangsa D, Meyer A, Sieben CJ et al (2021) Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis. Genes Dev 35:1079\u20131092. https:\/\/doi.org\/10.1101\/gad.348341.121","journal-title":"Genes Dev"},{"key":"9735_CR181","doi-asserted-by":"publisher","first-page":"e111559","DOI":"10.15252\/embj.2022111559","volume":"42","author":"MA Truong","year":"2023","unstructured":"Truong MA, Can\u00e9-Gasull P, de Vries SG, Nijenhuis W, Wardenaar R, Kapitein LC, Foijer F, Lens SMA (2023) A kinesin-based approach for inducing chromosome-specific mis-segregation in human cells. EMBO J 42:e111559. https:\/\/doi.org\/10.15252\/embj.2022111559","journal-title":"EMBO J"},{"key":"9735_CR182","doi-asserted-by":"crossref","unstructured":"Turocy J, Marin D, Xu S, Xu J, Robles A, Treff N, Egli D (2022) DNA double strand breaks cause chromosome loss through sister chromatid tethering in human embryos. bioRxiv 2022.03.10.483502","DOI":"10.1101\/2022.03.10.483502"},{"issue":"2","key":"9735_CR183","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1002\/gcc.2870140206","volume":"14","author":"H Uejima","year":"1995","unstructured":"Uejima H, Mitsuya K, Kugoh H, Horikawa I, Oshimura M (1995) Normal human chromosome 2 induces cellular senescence in the human cervical carcinoma cell line SiHa. Genes Chromosomes Cancer 14(2):120\u2013127. https:\/\/doi.org\/10.1002\/gcc.2870140206","journal-title":"Genes Chromosomes Cancer"},{"key":"9735_CR184","doi-asserted-by":"publisher","unstructured":"Umbreit NT, Zhang CZ, Lynch LD, Blaine LJ, Cheng AM, Tourdot R, Sun L, Almubarak HF, Judge K, Mitchell TJ, Spektor A, Pellman D (2020) Mechanisms generating cancer genome complexity from a single cell division error. Science 368(6488). https:\/\/doi.org\/10.1126\/science.aba0712","DOI":"10.1126\/science.aba0712"},{"issue":"1","key":"9735_CR185","doi-asserted-by":"publisher","first-page":"12739","DOI":"10.1038\/s41598-017-10418-7","volume":"7","author":"N Uno","year":"2017","unstructured":"Uno N, Hiramatsu K, Uno K, Komoto S, Kazuki Y, Oshimura M (2017) CRISPR\/Cas9-induced transgene insertion and telomere-associated truncation of a single human chromosome for chromosome engineering in CHO and A9 cells. Sci Rep 7(1):12739. https:\/\/doi.org\/10.1038\/s41598-017-10418-7","journal-title":"Sci Rep"},{"issue":"2","key":"9735_CR186","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0165-4608(98)00097-1","volume":"107","author":"N Uzawa","year":"1998","unstructured":"Uzawa N, Yoshida MA, Hosoe S, Oshimura M, Amagasa T, Ikeuchi T (1998) Functional evidence for involvement of multiple putative tumor suppressor genes on the short arm of chromosome 3 in human oral squamous cell carcinogenesis. Cancer Genet Cytogenet 107(2):125\u2013131. https:\/\/doi.org\/10.1016\/S0165-4608(98)00097-1","journal-title":"Cancer Genet Cytogenet"},{"issue":"10","key":"9735_CR187","first-page":"1997","volume":"11","author":"N Uzawa","year":"1995","unstructured":"Uzawa N, Yoshida MA, Oshimura M, Ikeuchi T (1995) Suppression of tumorigenicity in three different cell lines of human oral squamous cell carcinoma by introduction of chromosome 3p via microcell-mediated chromosome transfer. Oncogene 11(10):1997\u20132004","journal-title":"Oncogene"},{"issue":"9","key":"9735_CR188","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.tcb.2021.06.007","volume":"31","author":"SC van den Brink","year":"2021","unstructured":"van den Brink SC, van Oudenaarden A (2021) 3D gastruloids: a novel frontier in stem cell-based in vitro modeling of mammalian gastrulation. Trends Cell Biol 31(9):747\u2013759. https:\/\/doi.org\/10.1016\/j.tcb.2021.06.007","journal-title":"Trends Cell Biol"},{"issue":"10","key":"9735_CR189","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.trecan.2016.09.003","volume":"2","author":"RH van Jaarsveld","year":"2016","unstructured":"van Jaarsveld RH, Kops GJPL (2016) Difference makers: chromosomal instability versus aneuploidy in cancer. Trends Cancer 2(10):561\u2013571. https:\/\/doi.org\/10.1016\/j.trecan.2016.09.003","journal-title":"Trends Cancer"},{"issue":"4","key":"9735_CR190","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.devcel.2020.01.034","volume":"52","author":"A Vasudevan","year":"2020","unstructured":"Vasudevan A, Baruah PS, Smith JC, Wang Z, Sayles NM, Andrews P, Kendall J, Leu J, Chunduri NK, Levy D, Wigler M, Storchov\u00e1 Z, Sheltzer JM (2020) Single-chromosomal gains can function as metastasis suppressors and promoters in colon cancer. Dev Cell 52(4):413\u2013428.e6. https:\/\/doi.org\/10.1016\/j.devcel.2020.01.034","journal-title":"Dev Cell"},{"issue":"10","key":"9735_CR191","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/s10038-022-01049-6","volume":"67","author":"S Wakita","year":"2022","unstructured":"Wakita S, Hara M, Kitabatake Y, Kawatani K, Kurahashi H, Hashizume R (2022) Experimental method for haplotype phasing across the entire length of chromosome 21 in trisomy 21 cells using a chromosome elimination technique. J Hum Genet 67(10):565\u2013572. https:\/\/doi.org\/10.1038\/s10038-022-01049-6","journal-title":"J Hum Genet"},{"issue":"6609","key":"9735_CR192","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1126\/SCIENCE.ABM1964","volume":"377","author":"LB Wang","year":"2022","unstructured":"Wang LB, Li ZK, Wang LY, Xu K, Ji TT, Mao YH, Ma SN, Liu T, Tu CF, Zhao Q, Fan XN, Liu C, Wang LY, Shu YJ, Yang N, Zhou Q, Li W (2022) A sustainable mouse karyotype created by programmed chromosome fusion. Science 377(6609):967\u2013975. https:\/\/doi.org\/10.1126\/SCIENCE.ABM1964","journal-title":"Science"},{"issue":"3","key":"9735_CR193","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s10577-020-09636-z","volume":"28","author":"B Warecki","year":"2020","unstructured":"Warecki B, Sullivan W (2020) Mechanisms driving acentric chromosome transmission. Chromosome Res 28(3):229\u2013246. https:\/\/doi.org\/10.1007\/s10577-020-09636-z","journal-title":"Chromosome Res"},{"key":"9735_CR194","doi-asserted-by":"publisher","unstructured":"Weatherbee BA, Gantner CW, Daza RM, Hamazaki N, Iwamoto-Stohl LK, Shendure J, Zernicka-Goetz M (2023) Transgene directed induction of a stem cell-derived human embryo model. Nature. https:\/\/doi.org\/10.1038\/s41586-023-06368-y","DOI":"10.1038\/s41586-023-06368-y"},{"issue":"18","key":"9735_CR195","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1091\/mbc.e14-04-0916","volume":"25","author":"BA Weaver","year":"2014","unstructured":"Weaver BA (2014) How Taxol\/paclitaxel kills cancer cells. Mol Biol Cell 25(18):2677\u20132681. https:\/\/doi.org\/10.1091\/mbc.e14-04-0916","journal-title":"Mol Biol Cell"},{"issue":"6","key":"9735_CR196","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.ceb.2006.10.002","volume":"18","author":"BA Weaver","year":"2006","unstructured":"Weaver BA, Cleveland DW (2006) Does aneuploidy cause cancer? Curr Opin Cell Biol 18(6):658\u2013667. https:\/\/doi.org\/10.1016\/j.ceb.2006.10.002","journal-title":"Curr Opin Cell Biol"},{"issue":"4","key":"9735_CR197","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1083\/jcb.200303167","volume":"162","author":"BAA Weaver","year":"2003","unstructured":"Weaver BAA, Bonday ZQ, Putkey FR, Kops GJPL, Silk AD, Cleveland DW (2003) Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J Cell Biol 162(4):551\u2013563. https:\/\/doi.org\/10.1083\/jcb.200303167","journal-title":"J Cell Biol"},{"issue":"1","key":"9735_CR198","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ccr.2006.12.003","volume":"11","author":"BAA Weaver","year":"2007","unstructured":"Weaver BAA, Silk AD, Montagna C, Verdier-Pinard P, Cleveland DW (2007) Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 11(1):25\u201336. https:\/\/doi.org\/10.1016\/j.ccr.2006.12.003","journal-title":"Cancer Cell"},{"issue":"9","key":"9735_CR199","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1158\/0008-5472.CAN-07-3293","volume":"68","author":"IB Weinstein","year":"2008","unstructured":"Weinstein IB, Joe A (2008) Oncogene addiction. Cancer Res 68(9):3077\u20133080. https:\/\/doi.org\/10.1158\/0008-5472.CAN-07-3293","journal-title":"Cancer Res"},{"issue":"1","key":"9735_CR200","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-49837-z","volume":"9","author":"KS Whinn","year":"2019","unstructured":"Whinn KS, Kaur G, Lewis JS, Schauer GD, Mueller SH, Jergic S, Maynard H, Gan ZY, Naganbabu M, Bruchez MP, O\u2019Donnell ME, Dixon NE, van Oijen AM, Ghodke H (2019) Nuclease dead Cas9 is a programmable roadblock for DNA replication. Sci Rep 9(1):1\u20139. https:\/\/doi.org\/10.1038\/s41598-019-49837-z","journal-title":"Sci Rep"},{"issue":"5902","key":"9735_CR201","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1126\/science.1160058","volume":"322","author":"BR Williams","year":"2008","unstructured":"Williams BR, Prabhu VR, Hunter KE, Glazier CM, Whittaker CA, Housman DE, Amon A (2008) Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science 322(5902):703\u2013710","journal-title":"Science"},{"issue":"11","key":"9735_CR202","doi-asserted-by":"publisher","first-page":"3366","DOI":"10.1016\/J.CELREP.2018.05.047","volume":"23","author":"JT Worrall","year":"2018","unstructured":"Worrall JT, Tamura N, Mazzagatti A, Shaikh N, van Lingen T, Bakker B, Spierings DCJ, Vladimirou E, Foijer F, McClelland SE (2018) Non-random mis-segregation of human chromosomes. Cell Rep 23(11):3366\u20133380. https:\/\/doi.org\/10.1016\/J.CELREP.2018.05.047","journal-title":"Cell Rep"},{"issue":"21","key":"9735_CR203","doi-asserted-by":"publisher","first-page":"8212","DOI":"10.1073\/pnas.1206062109","volume":"109","author":"W Xue","year":"2012","unstructured":"Xue W, Kitzing T, Roessler S, Zuber J, Krasnitz A, Schultz N, Revill K, Weissmueller S, Rappaport AR, Simon J et al (2012) A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proc Natl Acad Sci U S A 109(21):8212\u20138217. https:\/\/doi.org\/10.1073\/pnas.1206062109","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"9735_CR204","first-page":"1141","volume":"5","author":"H Yamada","year":"1990","unstructured":"Yamada H, Wake N, Fujimoto S, Barrett JC, Oshimura M (1990) Multiple chromosomes carrying tumor suppressor activity for a uterine endometrial carcinoma cell line identified by microcell-mediated chromosome transfer. Oncogene 5(8):1141\u20131147","journal-title":"Oncogene"},{"issue":"21","key":"9735_CR205","first-page":"5483","volume":"59","author":"BA Yoshida","year":"1999","unstructured":"Yoshida BA, Dubauskas Z, Chekmareva MA, Christiano TR, Stadler WM, Rinker-Schaeffer CW (1999) Mitogen-activated protein kinase kinase 4\/stress-activated protein\/Erk kinase 1 (MKK4\/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 171. Cancer Res 59(21):5483\u20135487","journal-title":"Cancer Res"},{"issue":"21","key":"9735_CR206","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1093\/jnci\/92.21.1717","volume":"92","author":"BA Yoshida","year":"2000","unstructured":"Yoshida BA, Sokoloff MM, Welch DR, Rinker-Schaeffer CW (2000) Metastasis-suppressor genes: a review and perspective on an emerging field. JNCI J Natl Cancer Inst 92(21):1717\u20131730. https:\/\/doi.org\/10.1093\/jnci\/92.21.1717","journal-title":"JNCI J Natl Cancer Inst"},{"issue":"7555","key":"9735_CR207","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature14493","volume":"522","author":"CZ Zhang","year":"2015","unstructured":"Zhang CZ, Spektor A, Cornils H, Francis JM, Jackson EK, Liu S, Meyerson M, Pellman D (2015) Chromothripsis from DNA damage in micronuclei. Nature 522(7555):179\u2013184. https:\/\/doi.org\/10.1038\/nature14493","journal-title":"Nature"},{"issue":"4","key":"9735_CR208","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1242\/jcs.139725","volume":"127","author":"G Zhang","year":"2014","unstructured":"Zhang G, Lischetti T, Nilsson J (2014) A minimal number of MELT repeats supports all the functions of KNL1 in chromosome segregation. J Cell Sci 127(4):871\u2013884. https:\/\/doi.org\/10.1242\/jcs.139725","journal-title":"J Cell Sci"},{"issue":"11","key":"9735_CR209","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1038\/s41422-022-00722-x","volume":"32","author":"XM Zhang","year":"2022","unstructured":"Zhang XM, Yan M, Yang Z, Xiang H, Tang W, Cai X, Wu Q, Liu X, Pei G, Li J (2022) Creation of artificial karyotypes in mice reveals robustness of genome organization. Cell Res 32(11):1026\u20131029. https:\/\/doi.org\/10.1038\/s41422-022-00722-x","journal-title":"Cell Res"},{"issue":"1","key":"9735_CR210","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12920-019-0532-5","volume":"12","author":"Y Zhao","year":"2019","unstructured":"Zhao Y, Carter R, Natarajan S, Varn FS, Compton DA, Gawad C, Cheng C, Godek KM (2019) Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells. BMC Med Genomics 12(1):79. https:\/\/doi.org\/10.1186\/s12920-019-0532-5","journal-title":"BMC Med Genomics"},{"issue":"34","key":"9735_CR211","doi-asserted-by":"publisher","first-page":"26005","DOI":"10.1074\/jbc.M110.139196","volume":"285","author":"Y Zhu","year":"2010","unstructured":"Zhu Y, Kim YM, Li S, Zhuang Y (2010) Generation and analysis of partially haploid cells with Cre-mediated chromosome deletion in the lymphoid system. J Biol Chem 285(34):26005\u201326012. https:\/\/doi.org\/10.1074\/jbc.M110.139196","journal-title":"J Biol Chem"},{"issue":"6","key":"9735_CR212","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1016\/j.cell.2020.10.025","volume":"183","author":"MV Zuccaro","year":"2020","unstructured":"Zuccaro MV, Xu J, Mitchell C, Marin D, Zimmerman R, Rana B, Weinstein E, King RT, Palmerola KL, Smith ME, Tsang SH, Goland R, Jasin M, Lobo R, Treff N, Egli D (2020) Allele-specific chromosome removal after Cas9 cleavage in human embryos. Cell 183(6):1650\u20131664.e15. https:\/\/doi.org\/10.1016\/j.cell.2020.10.025","journal-title":"Cell"},{"issue":"1","key":"9735_CR213","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13059-017-1354-4","volume":"18","author":"E Zuo","year":"2017","unstructured":"Zuo E, Huo X, Yao X, Hu X, Sun Y, Yin J, He B, Wang X, Shi L, Ping J, Wei Y, Ying W, Wei W, Liu W, Tang C, Li Y, Hu J, Yang H (2017) CRISPR\/Cas9-mediated targeted chromosome elimination. Genome Biol 18(1):1\u201318. https:\/\/doi.org\/10.1186\/s13059-017-1354-4","journal-title":"Genome Biol"}],"container-title":["Chromosome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10577-023-09735-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10577-023-09735-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10577-023-09735-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T04:14:17Z","timestamp":1695615257000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10577-023-09735-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,29]]},"references-count":213,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["9735"],"URL":"https:\/\/doi.org\/10.1007\/s10577-023-09735-7","relation":{},"ISSN":["1573-6849"],"issn-type":[{"value":"1573-6849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,29]]},"assertion":[{"value":"28 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable: the study does not involve human participants\/tissues or animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable. The study does not involve human participants\/tissues or animals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable: the study does not involve human participants\/tissues or animals.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"25"}}