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This study seeks to examine the mental health needs of a large sample of treatment-seeking TGNC youth by comparing them to cisgender males and females. Participants were 94,804 children and youth ages 4\u201318\u00a0years (<jats:italic>M<\/jats:italic>\u2009=\u200912.1, SD\u2009=\u20093.72) who completed the interRAI Child and Youth Mental Health Instrument (ChYMH) or Screener (ChYMH-S) at participating mental health agencies in the Ontario, Canada. Overall, the mental health presentations of TGNC youth were similar to cisgender females but at higher acuity levels. TGNC youth showed significantly higher levels of anxiety, depression, social disengagement, positive symptoms, risk of suicide\/self-harm, and were more likely to report experiencing emotional abuse, past suicide attempts, and a less strong, supportive family relationship than cisgender females and males. Clinical implications of these findings are discussed.<\/jats:p>","DOI":"10.1007\/s10578-021-01289-1","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T13:03:53Z","timestamp":1638536633000},"page":"826-836","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Examining the Mental Health Presentations of Treatment-Seeking Transgender and Gender Nonconforming (TGNC) Youth"],"prefix":"10.1007","volume":"54","author":[{"given":"Shannon L.","family":"Stewart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2441-2184","authenticated-orcid":false,"given":"Jocelyn N.","family":"Van Dyke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey W.","family":"Poss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,3]]},"reference":[{"key":"1289_CR1","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.jadohealth.2017.04.014","volume":"61","author":"ME Eisenberg","year":"2017","unstructured":"Eisenberg ME, Gower AL, McMorris BJ, Rider GN, Shea G, Coleman E (2017) Risk and protective factors in the lives of transgender\/gender nonconforming adolescents. 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