{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:33:12Z","timestamp":1790919192516,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5-6","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Metastasis"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1007\/s10585-006-9038-6","type":"journal-article","created":{"date-parts":[[2006,11,3]],"date-time":"2006-11-03T01:31:40Z","timestamp":1162517500000},"page":"291-300","source":"Crossref","is-referenced-by-count":100,"title":["Role of CCR1 and CCR5 in homing and growth of multiple myeloma and in the development of osteolytic lesions: a study in the 5TMM model"],"prefix":"10.1007","volume":"23","author":[{"given":"Eline","family":"Menu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evy","family":"De Leenheer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"De Raeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Les","family":"Coulton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Imanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els","family":"Van Valckenborgh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Van Riet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Van Camp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Horuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Croucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Vanderkerken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,11,3]]},"reference":[{"key":"9038_CR1","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1182\/blood.V80.9.2326.2326","volume":"80","author":"MH Bakkus","year":"1992","unstructured":"Bakkus MH, Heirman C, Van Riet I et al (1992) Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation. Blood 80:2326\u20132335","journal-title":"Blood"},{"key":"9038_CR2","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1182\/blood.V77.12.2688.2688","volume":"77","author":"F Caligaris-Cappio","year":"1991","unstructured":"Caligaris-Cappio F, Bergui L, Gregoretti MG et al (1991) Role of bone marrow stromal cells in the growth of human multiple myeloma. Blood 77:2688\u20132693","journal-title":"Blood"},{"key":"9038_CR3","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1182\/blood.V84.7.2269.2269","volume":"84","author":"HM Lokhorst","year":"1994","unstructured":"Lokhorst HM, Lamme T, de Smet M et al (1994) Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures. Blood 84:2269\u20132277","journal-title":"Blood"},{"key":"9038_CR4","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.1182\/blood.V82.12.3712.3712","volume":"82","author":"H Uchiyama","year":"1993","unstructured":"Uchiyama H, Barut BA, Mohrbacher AF et al (1993) Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion. Blood 82:3712\u20133720","journal-title":"Blood"},{"key":"9038_CR5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3109\/10428199309145751","volume":"9","author":"I Riet Van","year":"1993","unstructured":"Van Riet I, Van Camp B (1993) The involvement of adhesion molecules in the biology of multiple myeloma. Leuk Lymphoma 9:441\u2013452","journal-title":"Leuk Lymphoma"},{"key":"9038_CR6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.272.5258.60","volume":"272","author":"EC Butcher","year":"1996","unstructured":"Butcher EC, Picker LJ (1996) Lymphocyte homing and homeostasis. Science 272:60\u201366","journal-title":"Science"},{"key":"9038_CR7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1349-7006.2005.00059.x","volume":"96","author":"T Tanaka","year":"2005","unstructured":"Tanaka T, Bai Z, Srinoulprasert Y et al (2005) Chemokines in tumor progression and metastasis. Cancer Sci 96:317\u2013322","journal-title":"Cancer Sci"},{"key":"9038_CR8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/84209","volume":"2","author":"C Gerard","year":"2001","unstructured":"Gerard C, Rollins BJ (2001) Chemokines and disease. Nat Immunol 2:108\u2013115","journal-title":"Nat Immunol"},{"key":"9038_CR9","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1152\/ajpregu.00738.2001","volume":"283","author":"TS Olson","year":"2002","unstructured":"Olson TS, Ley K (2002) Chemokines and chemokine receptors in leukocyte trafficking. Am J Physiol Regul Integr Comp Physiol 283:R7\u2013R28","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"9038_CR10","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1359-6101(02)00045-X","volume":"13","author":"P Menten","year":"2002","unstructured":"Menten P, Wuyts A, Van Damme J (2002) Macrophage inflammatory protein-1. Cytokine Growth Factor Rev 13:455\u2013481","journal-title":"Cytokine Growth Factor Rev"},{"key":"9038_CR11","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1084\/jem.177.6.1821","volume":"177","author":"TJ Schall","year":"1993","unstructured":"Schall TJ, Bacon K, Camp RD et al (1993) Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes. J Exp Med 177:1821\u20131826","journal-title":"J Exp Med"},{"key":"9038_CR12","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1182\/blood-2002-08-2383","volume":"101","author":"S Lentzsch","year":"2003","unstructured":"Lentzsch S, Gries M, Janz M et al (2003) Macrophage inflammatory protein 1-alpha (MIP-1 alpha) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells. Blood 101:3568\u20133573","journal-title":"Blood"},{"key":"9038_CR13","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1182\/blood.V96.2.671","volume":"96","author":"SJ Choi","year":"2000","unstructured":"Choi SJ, Cruz JC, Craig F et al (2000) Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma. Blood 96:671\u2013675","journal-title":"Blood"},{"key":"9038_CR14","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1182\/blood.V97.11.3349","volume":"97","author":"JH Han","year":"2001","unstructured":"Han JH, Choi SJ, Kurihara N et al (2001) Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand. Blood 97:3349\u20133353","journal-title":"Blood"},{"key":"9038_CR15","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1172\/JCI200113116","volume":"108","author":"SJ Choi","year":"2001","unstructured":"Choi SJ, Oba Y, Gazitt Y et al (2001) Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease. J Clin Invest 108:1833\u20131841","journal-title":"J Clin Invest"},{"key":"9038_CR16","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1182\/blood.V100.6.2195","volume":"100","author":"M Abe","year":"2002","unstructured":"Abe M, Hiura K, Wilde J et al (2002) Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myeloma. Blood 100:2195\u20132202","journal-title":"Blood"},{"key":"9038_CR17","first-page":"6065","volume":"154","author":"K Fuller","year":"1995","unstructured":"Fuller K, Owens JM, Chambers TJ (1995) Macrophage inflammatory protein-1 alpha and IL-8 stimulate the motility but suppress the resorption of isolated rat osteoclasts. J Immunol 154:6065\u20136072","journal-title":"J Immunol"},{"key":"9038_CR18","first-page":"399","volume":"76","author":"T Kukita","year":"1997","unstructured":"Kukita T, Nomiyama H, Ohmoto Y et al (1997) Macrophage inflammatory protein-1 alpha (LD78) expressed in human bone marrow: its role in regulation of hematopoiesis and osteoclast recruitment. Lab Invest 76:399\u2013406","journal-title":"Lab Invest"},{"key":"9038_CR19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1182\/blood-2002-12-3905","volume":"102","author":"BO Oyajobi","year":"2003","unstructured":"Oyajobi BO, Franchin G, Williams PJ et al (2003) Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease. Blood 102:311\u2013319","journal-title":"Blood"},{"key":"9038_CR20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-1-4419-9129-4_4","volume":"118","author":"GD Roodman","year":"2004","unstructured":"Roodman GD, Choi SJ (2004) MIP-1 alpha and myeloma bone disease. Cancer Treat Res 118:83\u2013100","journal-title":"Cancer Treat Res"},{"key":"9038_CR21","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1046\/j.1365-2141.2003.04712.x","volume":"123","author":"E Terpos","year":"2003","unstructured":"Terpos E, Politou M, Rahemtulla A (2003) New insights into the pathophysiology and management of bone disease in multiple myeloma. Br J Haematol 123:758\u2013769","journal-title":"Br J Haematol"},{"key":"9038_CR22","first-page":"609","volume":"122","author":"J Radl","year":"1979","unstructured":"Radl J, De Glopper E, Schuit HRE et al (1979) Idiopathic paraproteinemia II. Transplantation of the paraprotein-producing clone from old to young C57BL\/KaLwRij mice. J Immunol 122:609\u2013613","journal-title":"J Immunol"},{"key":"9038_CR23","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1054\/bjoc.1999.1024","volume":"82","author":"K Vanderkerken","year":"2000","unstructured":"Vanderkerken K, De Greef C, Asosingh K et al (2000) Selective initial in vivo homing pattern of 5T2 multiple myeloma cells in the C57BL\/KalwRij mouse. Br J Cancer 82:953\u2013959","journal-title":"Br J Cancer"},{"key":"9038_CR24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/bjc.1997.409","volume":"76","author":"K Vanderkerken","year":"1997","unstructured":"Vanderkerken K, De Raeve H, Goes E et al (1997) Organ involvement and phenotypic adhesion profile of 5T2 and 5T33 myeloma cells in the C57BL\/KaLwRij mouse. Br J Cancer 76:451\u2013460","journal-title":"Br J Cancer"},{"key":"9038_CR25","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/sj.thj.6200052","volume":"1","author":"K Asosingh","year":"2000","unstructured":"Asosingh K, Radl J, Van Riet I et al (2000) The 5TMM series, a useful in vivo mouse model of human multiple myeloma. Hematol J 1:351\u2013356","journal-title":"Hematol J"},{"key":"9038_CR26","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1034\/j.1600-065X.2003.00035.x","volume":"194","author":"K Vanderkerken","year":"2003","unstructured":"Vanderkerken K, Asosingh K, Croucher P et al ( 2003) Multiple myeloma biology: lessons from the 5TMM models. Immunol Rev 194:196\u2013206","journal-title":"Immunol Rev"},{"key":"9038_CR27","doi-asserted-by":"crossref","first-page":"19000","DOI":"10.1074\/jbc.M001222200","volume":"275","author":"M Liang","year":"2000","unstructured":"Liang M, Mallari C, Rosser M et al (2000) Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J Biol Chem 275:19000\u201319008","journal-title":"J Biol Chem"},{"key":"9038_CR28","doi-asserted-by":"crossref","first-page":"5698","DOI":"10.1073\/pnas.96.10.5698","volume":"96","author":"M Baba","year":"1999","unstructured":"Baba M, Nishimura O, Kanzaki N et al (1999) A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc Natl Acad Sci USA 96:5698\u20135703","journal-title":"Proc Natl Acad Sci USA"},{"key":"9038_CR29","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/sj.bjc.6600137","volume":"86","author":"E Valckenborgh Van","year":"2002","unstructured":"Van Valckenborgh E, De Raeve H, Devy L et al (2002) Murine 5T multiple myeloma cells induce angiogenesis in vitro and in vivo. Br J Cancer 86:796\u2013802","journal-title":"Br J Cancer"},{"key":"9038_CR30","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1182\/blood.V98.13.3534","volume":"98","author":"PI Croucher","year":"2001","unstructured":"Croucher PI, Shipman CM, Lippitt J et al (2001) Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma. Blood 98:3534\u20133540","journal-title":"Blood"},{"key":"9038_CR31","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1046\/j.1365-2141.2003.04561.x","volume":"123","author":"E Terpos","year":"2003","unstructured":"Terpos E, Politou M, Szydlo R et al (2003) Serum levels of macrophage inflammatory protein-1 alpha (MIP-1alpha) correlate with the extent of bone disease and survival in patients with multiple myeloma. Br J Haematol 123:106\u2013109","journal-title":"Br J Haematol"},{"key":"9038_CR32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2141.2004.04864.x","volume":"125","author":"T Hashimoto","year":"2004","unstructured":"Hashimoto T, Abe M, Oshima T et al (2004). Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)-1alpha and MIP-1beta correlates with lytic bone lesions in patients with multiple myeloma. Br J Haematol 125:38\u201341","journal-title":"Br J Haematol"},{"key":"9038_CR33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bcmd.2004.04.012","volume":"33","author":"E Menu","year":"2004","unstructured":"Menu E, Asosingh K, Van Riet I et al (2004) Myeloma cells (5TMM) and their interactions with the marrow microenvironment. Blood Cells Mol Dis 33:111\u2013119","journal-title":"Blood Cells Mol Dis"},{"key":"9038_CR34","first-page":"605","volume":"91","author":"E Menu","year":"2006","unstructured":"Menu E, Asosingh K, Indraccolo S et al (2006) The involvement of stromal derived factor 1alpha in homing and progression of multiple myeloma in the 5TMM model. Haematologica 91:605\u2013612","journal-title":"Haematologica"},{"key":"9038_CR35","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.exphem.2004.11.015","volume":"33","author":"Y Oba","year":"2005","unstructured":"Oba Y, Lee JW, Ehrlich LA et al (2005) MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells. Exp Hematol 33:272\u2013278","journal-title":"Exp Hematol"}],"container-title":["Clinical & Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-006-9038-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10585-006-9038-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-006-9038-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T21:59:11Z","timestamp":1587247151000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10585-006-9038-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":35,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["9038"],"URL":"https:\/\/doi.org\/10.1007\/s10585-006-9038-6","relation":{},"ISSN":["0262-0898","1573-7276"],"issn-type":[{"value":"0262-0898","type":"print"},{"value":"1573-7276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}