{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:27:40Z","timestamp":1759742860119},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T00:00:00Z","timestamp":1329782400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Metastasis"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1007\/s10585-011-9448-y","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T06:51:38Z","timestamp":1329720698000},"page":"397-408","source":"Crossref","is-referenced-by-count":4,"title":["Time-dependent transcriptional profiling links gene expression to mitogen-activated protein kinase kinase 4 (MKK4)-mediated suppression of omental metastatic colonization"],"prefix":"10.1007","volume":"29","author":[{"given":"Russell O.","family":"Bainer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Taylor","family":"Veneris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Diane","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Montag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark W.","family":"Lingen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoav","family":"Gilad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie W.","family":"Rinker-Schaeffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,2,21]]},"reference":[{"issue":"9","key":"9448_CR1","first-page":"2651","volume":"38","author":"IJ Fidler","year":"1978","unstructured":"Fidler IJ (1978) Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res 38(9):2651\u20132660","journal-title":"Cancer Res"},{"issue":"5743","key":"9448_CR2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/283139a0","volume":"283","author":"G Poste","year":"1980","unstructured":"Poste G, Fidler IJ (1980) The pathogenesis of cancer metastasis. Nature 283(5743):139\u2013146","journal-title":"Nature"},{"issue":"1","key":"9448_CR3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.canlet.2008.05.012","volume":"272","author":"JL Taylor","year":"2008","unstructured":"Taylor JL et al (2008) New paradigms for the function of JNKK1\/MKK4 in controlling growth of disseminated cancer cells. Cancer Lett 272(1):12\u201322","journal-title":"Cancer Lett"},{"issue":"2","key":"9448_CR4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.semcancer.2010.12.008","volume":"21","author":"S Thiolloy","year":"2011","unstructured":"Thiolloy S et al (2011) Thinking outside the box: using metastasis suppressors as molecular tools. Semin Cancer Biol 21(2):89\u201398","journal-title":"Semin Cancer Biol"},{"issue":"11","key":"9448_CR5","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1001\/archsurg.141.11.1095","volume":"141","author":"SC Cunningham","year":"2006","unstructured":"Cunningham SC et al (2006) MKK4 status predicts survival after resection of gastric adenocarcinoma. Arch Surg 141(11):1095\u20131099 discussion 1100","journal-title":"Arch Surg"},{"issue":"22","key":"9448_CR6","first-page":"6717","volume":"62","author":"SD Yamada","year":"2002","unstructured":"Yamada SD et al (2002) Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma. Cancer Res 62(22):6717\u20136723","journal-title":"Cancer Res"},{"issue":"4","key":"9448_CR7","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s13277-011-0166-5","volume":"32","author":"S Yeasmin","year":"2011","unstructured":"Yeasmin S et al (2011) MKK4 acts as a potential tumor suppressor in ovarian cancer. Tumour Biol 32(4):661\u2013670","journal-title":"Tumour Biol"},{"issue":"7","key":"9448_CR8","first-page":"2833","volume":"61","author":"HL Kim","year":"2001","unstructured":"Kim HL et al (2001) Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers. Cancer Res 61(7):2833\u20132837","journal-title":"Cancer Res"},{"key":"9448_CR9","doi-asserted-by":"crossref","unstructured":"Szmulewitz RZ et al (2011) MKK4 suppresses metastatic colonization by multiple highly metastatic prostate cancer cell lines through a transient impairment in cell cycle progression. Int J Cancer. doi: 10.1002\/ijc.26005","DOI":"10.1002\/ijc.26005"},{"issue":"4","key":"9448_CR10","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.ajog.2004.02.005","volume":"190","author":"A Berchuck","year":"2004","unstructured":"Berchuck A et al (2004) Prediction of optimal versus suboptimal cytoreduction of advanced-stage serous ovarian cancer with the use of microarrays. Am J Obstet Gynecol 190(4):910\u2013925","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"9448_CR11","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1158\/0008-5472.CAN-05-3676","volume":"66","author":"JA Hickson","year":"2006","unstructured":"Hickson JA et al (2006) The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma. Cancer Res 66(4):2264\u20132270","journal-title":"Cancer Res"},{"issue":"7","key":"9448_CR12","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1158\/0008-5472.CAN-07-1568","volume":"68","author":"TL Lotan","year":"2008","unstructured":"Lotan TL et al (2008) c-Jun NH2-terminal kinase activating kinase 1\/mitogen-activated protein kinase kinase 4-mediated inhibition of SKOV3ip. 1 ovarian cancer metastasis involves growth arrest and p21 up-regulation. Cancer Res 68(7):2166\u20132175","journal-title":"Cancer Res"},{"issue":"4","key":"9448_CR13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1046-2023(03)00155-5","volume":"31","author":"GK Smyth","year":"2003","unstructured":"Smyth GK, Speed T (2003) Normalization of cDNA microarray data. Methods 31(4):265\u2013273","journal-title":"Methods"},{"issue":"1","key":"9448_CR14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1073\/pnas.011404098","volume":"98","author":"C Li","year":"2001","unstructured":"Li C, Wong WH (2001) Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci USA 98(1):31\u201336","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"9448_CR15","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","volume":"20","author":"L Gautier","year":"2004","unstructured":"Gautier L et al (2004) affy\u2014analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20(3):307\u2013315","journal-title":"Bioinformatics"},{"issue":"16","key":"9448_CR16","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","volume":"100","author":"JD Storey","year":"2003","unstructured":"Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100(16):9440\u20139445","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"9448_CR17","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","volume":"4","author":"G Dennis Jr","year":"2003","unstructured":"Dennis G Jr et al (2003) DAVID: database for annotation, visualization, and integrated discovery. Genome Biol 4(5):P3","journal-title":"Genome Biol"},{"issue":"1","key":"9448_CR18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"DW Huang","year":"2009","unstructured":"Huang DW, Sherman B, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4(1):44\u201357","journal-title":"Nat Protoc"},{"issue":"3","key":"9448_CR19","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1158\/0008-5472.CAN-05-3694","volume":"66","author":"ND Hendrix","year":"2006","unstructured":"Hendrix ND et al (2006) Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas. Cancer Res 66(3):1354\u20131362","journal-title":"Cancer Res"},{"key":"9448_CR20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1755-8794-1-13","volume":"1","author":"AI Riker","year":"2008","unstructured":"Riker AI et al (2008) The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. BMC Med Genomics 1:13","journal-title":"BMC Med Genomics"},{"issue":"10","key":"9448_CR21","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1038\/sj.bjc.6604681","volume":"99","author":"MA Pantaleo","year":"2008","unstructured":"Pantaleo MA et al (2008) Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice. Br J Cancer 99(10):1729\u20131734","journal-title":"Br J Cancer"},{"issue":"13","key":"9448_CR22","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1200\/JCO.2008.19.2542","volume":"27","author":"K Scotlandi","year":"2009","unstructured":"Scotlandi K et al (2009) Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome. J Clin Oncol 27(13):2209\u20132216","journal-title":"J Clin Oncol"},{"issue":"5","key":"9448_CR23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1200\/JCO.2006.06.3743","volume":"25","author":"HK Dressman","year":"2007","unstructured":"Dressman HK et al (2007) An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer. J Clin Oncol 25(5):517\u2013525","journal-title":"J Clin Oncol"},{"issue":"16","key":"9448_CR24","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1158\/1078-0432.CCR-08-0196","volume":"14","author":"RW Tothill","year":"2008","unstructured":"Tothill RW et al (2008) Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res 14(16):5198\u20135208","journal-title":"Clin Cancer Res"},{"issue":"6","key":"9448_CR25","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrclinonc.2011.65","volume":"8","author":"AN Shoushtari","year":"2011","unstructured":"Shoushtari AN et al (2011) Metastasis-suppressor genes in clinical practice: lost in translation? Nat Rev Clin Oncol 8(6):333\u2013342","journal-title":"Nat Rev Clin Oncol"},{"issue":"6","key":"9448_CR26","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/bjc.2011.37","volume":"104","author":"JY Lee","year":"2011","unstructured":"Lee JY et al (2011) Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion. Br J Cancer 104(6):1027\u20131037","journal-title":"Br J Cancer"},{"issue":"4","key":"9448_CR27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1440-1789.2008.00984.x","volume":"29","author":"N Saito","year":"2009","unstructured":"Saito N et al (2009) Dynamics of global gene expression changes during brain metastasis formation. Neuropathology 29(4):389\u2013397","journal-title":"Neuropathology"},{"issue":"3","key":"9448_CR28","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1158\/0008-5472.CAN-09-2703","volume":"70","author":"M Dutertre","year":"2010","unstructured":"Dutertre M et al (2010) Exon-based clustering of murine breast tumor transcriptomes reveals alternative exons whose expression is associated with metastasis. Cancer Res 70(3):896\u2013905","journal-title":"Cancer Res"},{"issue":"25","key":"9448_CR29","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1056\/NEJMoa021967","volume":"347","author":"MJ Vijver van de","year":"2002","unstructured":"van de Vijver MJ et al (2002) A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 347(25):1999\u20132009","journal-title":"N Engl J Med"},{"issue":"4","key":"9448_CR30","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nm843","volume":"9","author":"QH Ye","year":"2003","unstructured":"Ye QH et al (2003) Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med 9(4):416\u2013423","journal-title":"Nat Med"},{"issue":"10","key":"9448_CR31","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/ng1634","volume":"37","author":"PB Gupta","year":"2005","unstructured":"Gupta PB et al (2005) The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat Genet 37(10):1047\u20131054","journal-title":"Nat Genet"},{"issue":"3","key":"9448_CR32","doi-asserted-by":"crossref","first-page":"R32","DOI":"10.1186\/bcr2317","volume":"11","author":"Y Matsuda","year":"2009","unstructured":"Matsuda Y et al (2009) WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth. Breast Cancer Res 11(3):R32","journal-title":"Breast Cancer Res"},{"issue":"7050","key":"9448_CR33","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nature03799","volume":"436","author":"AJ Minn","year":"2005","unstructured":"Minn AJ et al (2005) Genes that mediate breast cancer metastasis to lung. Nature 436(7050):518\u2013524","journal-title":"Nature"},{"issue":"43","key":"9448_CR34","doi-asserted-by":"crossref","first-page":"18616","DOI":"10.1073\/pnas.1004654107","volume":"107","author":"H DeLisser","year":"2010","unstructured":"DeLisser H et al (2010) Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression. Proc Natl Acad Sci USA 107(43):18616\u201318621","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"9448_CR35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00024382-200207000-00010","volume":"18","author":"ID McGilvray","year":"2002","unstructured":"McGilvray ID et al (2002) Monocyte adhesion and transmigration induce tissue factor expression: role of the mitogen-activated protein kinases. Shock 18(1):51\u201357","journal-title":"Shock"},{"issue":"43","key":"9448_CR36","doi-asserted-by":"crossref","first-page":"29396","DOI":"10.1074\/jbc.M802821200","volume":"283","author":"SC Wu","year":"2008","unstructured":"Wu SC et al (2008) Hepatitis C virus NS5A protein down-regulates the expression of spindle gene Aspm through PKR-p38 signaling pathway. J Biol Chem 283(43):29396\u201329404","journal-title":"J Biol Chem"},{"issue":"94","key":"9448_CR37","doi-asserted-by":"crossref","first-page":"ra69","DOI":"10.1126\/scisignal.2000442","volume":"2","author":"BS Marasa","year":"2009","unstructured":"Marasa BS et al (2009) Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs. Sci Signal 2(94):ra69","journal-title":"Sci Signal"},{"issue":"1","key":"9448_CR38","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/ijc.25332","volume":"128","author":"S Yeasmin","year":"2011","unstructured":"Yeasmin S et al (2011) Loss of MKK4 expression in ovarian cancer: a potential role for the epithelial to mesenchymal transition. Int J Cancer 128(1):94\u2013104","journal-title":"Int J Cancer"}],"container-title":["Clinical &amp; Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-011-9448-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10585-011-9448-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-011-9448-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T20:25:22Z","timestamp":1561321522000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10585-011-9448-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,21]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["9448"],"URL":"https:\/\/doi.org\/10.1007\/s10585-011-9448-y","relation":{},"ISSN":["0262-0898","1573-7276"],"issn-type":[{"value":"0262-0898","type":"print"},{"value":"1573-7276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,21]]}}}