{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:59:45Z","timestamp":1791853185349,"version":"4.3.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medizinische Universit\u00e4t Wien","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Metastasis"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s10585-018-9947-1","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T08:30:46Z","timestamp":1542011446000},"page":"727-738","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Brain metastases as first manifestation of advanced cancer: exploratory analysis of 459 patients at a tertiary care center"],"prefix":"10.1007","volume":"35","author":[{"given":"L. M.","family":"F\u00fcreder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Widhalm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gatterbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Dieckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Hainfellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bartsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. C.","family":"Zielinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Preusser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Berghoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"issue":"2","key":"9947_CR1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00701-003-0188-x","volume":"146","author":"S Agazzi","year":"2004","unstructured":"Agazzi S, Pampallona S, Pica A, Vernet O, Regli L, Porchet F et al (2004) The origin of brain metastases in patients with an undiagnosed primary tumour. Acta Neurochir 146(2):153\u2013157","journal-title":"Acta Neurochir"},{"issue":"1","key":"9947_CR2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/BF01058462","volume":"23","author":"M Salvati","year":"1995","unstructured":"Salvati M, Cervoni L, Raco A (1995) Single brain metastases from unknown primary malignancies in CT-era. J Neuro-oncol 23(1):75\u201380","journal-title":"J Neuro-oncol"},{"issue":"3","key":"9947_CR3","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1023\/A:1006413001375","volume":"50","author":"MT Giordana","year":"2000","unstructured":"Giordana MT, Cordera S, Boghi A (2000) Cerebral metastases as first symptom of cancer: a clinico-pathologic study. J Neuro-oncol 50(3):265\u2013273","journal-title":"J Neuro-oncol"},{"issue":"14","key":"9947_CR4","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1016\/S0959-8049(03)00547-1","volume":"39","author":"N Pavlidis","year":"2003","unstructured":"Pavlidis N, Briasoulis E, Hainsworth J, Greco FA (2003) Diagnostic and therapeutic management of cancer of an unknown primary. Eur J Cancer 39(14):1990\u20132005","journal-title":"Eur J Cancer"},{"issue":"4","key":"9947_CR5","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1200\/JCO.2011.38.0527","volume":"30","author":"PW Sperduto","year":"2012","unstructured":"Sperduto PW, Kased N, Roberge D, Xu Z, Shanley R, Luo X et al (2012) Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol 30(4):419\u2013425","journal-title":"J Clin Oncol"},{"key":"9947_CR6","doi-asserted-by":"crossref","unstructured":"Sperduto CM, Watanabe Y, Mullan J, Hood T, Dyste G, Watts C et al. A validation study of a new prognostic index for patients with brain metastases: the Graded Prognostic Assessment. J Neurosurg. 2008;109 Suppl:87 \u2013 9","DOI":"10.3171\/JNS\/2008\/109\/12\/S14"},{"issue":"2","key":"9947_CR7","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.ijrobp.2007.06.074","volume":"70","author":"PW Sperduto","year":"2008","unstructured":"Sperduto PW, Berkey B, Gaspar LE, Mehta M, Curran W (2008) A new prognostic index and comparison to three other indices for patients with brain metastases: an analysis of 1,960 patients in the RTOG database. Int J Radiat Oncol Biol Phys 70(2):510\u2013514","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"9947_CR8","doi-asserted-by":"publisher","first-page":"e000024","DOI":"10.1136\/esmoopen-2015-000024","volume":"1","author":"AS Berghoff","year":"2016","unstructured":"Berghoff AS, Schur S, F\u00fcreder LM, Gatterbauer B, Dieckmann K, Widhalm G et al (2016) Descriptive statistical analysis of a real life cohort of 2419 patients with brain metastases of solid cancers. ESMO Open 1:e000024","journal-title":"ESMO Open"},{"issue":"2","key":"9947_CR9","doi-asserted-by":"publisher","first-page":"e000024","DOI":"10.1136\/esmoopen-2015-000024","volume":"1","author":"AS Berghoff","year":"2016","unstructured":"Berghoff AS, Schur S, Fureder LM, Gatterbauer B, Dieckmann K, Widhalm G et al (2016) Descriptive statistical analysis of a real life cohort of 2419 patients with brain metastases of solid cancers. ESMO Open 1(2):e000024","journal-title":"ESMO Open"},{"issue":"24","key":"9947_CR10","doi-asserted-by":"publisher","first-page":"6078","DOI":"10.1158\/1078-0432.CCR-16-1327","volume":"22","author":"M Osswald","year":"2016","unstructured":"Osswald M, Blaes J, Liao Y, Solecki G, Gommel M, Berghoff AS et al (2016) Impact of blood-brain barrier integrity on tumor growth and therapy response in brain metastases. Clin Cancer Res 22(24):6078\u20136087","journal-title":"Clin Cancer Res"},{"issue":"5","key":"9947_CR11","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1080\/0284186X.2017.1290272","volume":"56","author":"TD Christensen","year":"2017","unstructured":"Christensen TD, Palshof JA, Larsen FO, Hogdall E, Poulsen TS, Pfeiffer P et al (2017) Risk factors for brain metastases in patients with metastatic colorectal cancer. Acta Oncol (Stockholm Sweden) 56(5):639\u2013645","journal-title":"Acta Oncol (Stockholm Sweden)"},{"key":"9947_CR12","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx365.034","author":"SF El Zawawy","year":"2017","unstructured":"El Zawawy SF (2017) 271PCan we predict subsequent brain metastasis in patients with metastatic breast cancer? Ann Oncol \n                    https:\/\/doi.org\/10.1093\/annonc\/mdx365.034","journal-title":"Ann Oncol"},{"issue":"1","key":"9947_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00280-011-1775-9","volume":"69","author":"AP Kyritsis","year":"2012","unstructured":"Kyritsis AP, Markoula S, Levin VA (2012) A systematic approach to the management of patients with brain metastases of known or unknown primary site. Cancer Chemother Pharmacol 69(1):1\u201313","journal-title":"Cancer Chemother Pharmacol"},{"issue":"3","key":"9947_CR14","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1136\/jnnp.61.3.321","volume":"61","author":"M Pol van de","year":"1996","unstructured":"van de Pol M, van Aalst VC, Wilmink JT, Twijnstra A (1996) Brain metastases from an unknown primary tumour: which diagnostic procedures are indicated? J Neurol Neurosurg Psychiatry 61(3):321\u2013323","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5","key":"9947_CR15","first-page":"601","volume":"37","author":"M Debevec","year":"1990","unstructured":"Debevec M (1990) Management of patients with brain metastases of unknown origin. Neoplasma 37(5):601\u2013606","journal-title":"Neoplasma"},{"key":"9947_CR16","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ejca.2018.03.010","volume":"96","author":"F Wolpert","year":"2018","unstructured":"Wolpert F, Weller M, Berghoff AS, Rushing E, Fureder LM, Petyt G et al (2018) Diagnostic value of (18)F-fluordesoxyglucose positron emission tomography for patients with brain metastasis from unknown primary site. Eur J Cancer 96:64\u201372","journal-title":"Eur J Cancer"},{"issue":"3","key":"9947_CR17","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.ejca.2012.09.005","volume":"49","author":"AC Waal de","year":"2013","unstructured":"de Waal AC, Aben KK, van Rossum MM, Kiemeney LA (2013) Melanoma of unknown primary origin: a population-based study in the Netherlands. Eur J Cancer 49(3):676\u2013683","journal-title":"Eur J Cancer"},{"issue":"1","key":"9947_CR18","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1097\/00008390-200502000-00013","volume":"15","author":"KA Katz","year":"2005","unstructured":"Katz KA, Jonasch E, Hodi FS, Soiffer R, Kwitkiwski K, Sober AJ et al (2005) Melanoma of unknown primary: experience at Massachusetts General Hospital and Dana-Farber Cancer Institute. Melanoma Res 15(1):77\u201382","journal-title":"Melanoma Res"},{"issue":"3","key":"9947_CR19","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1097\/CMR.0b013e32834577ec","volume":"21","author":"AF Pfeil","year":"2011","unstructured":"Pfeil AF, Leiter U, Buettner PG, Eigentler TK, Weide B, Meier F et al (2011) Melanoma of unknown primary is correctly classified by the AJCC melanoma classification from 2009. Melanoma Res 21(3):228\u2013234","journal-title":"Melanoma Res"},{"issue":"1","key":"9947_CR20","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jaad.2014.09.029","volume":"72","author":"JM Bae","year":"2015","unstructured":"Bae JM, Choi YY, Kim DS, Lee JH, Jang HS, Lee JH et al (2015) Metastatic melanomas of unknown primary show better prognosis than those of known primary: a systematic review and meta-analysis of observational studies. J Am Acad Dermatol 72(1):59\u201370","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"9947_CR21","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1023\/A:1025621819250","volume":"64","author":"S Bartelt","year":"2003","unstructured":"Bartelt S, Lutterbach J (2003) Brain metastases in patients with cancer of unknown primary. J Neuro-oncol 64(3):249\u2013253","journal-title":"J Neuro-oncol"},{"issue":"5","key":"9947_CR22","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1002\/1097-0142(20000901)89:5<1095::AID-CNCR19>3.0.CO;2-H","volume":"89","author":"S Maesawa","year":"2000","unstructured":"Maesawa S, Kondziolka D, Thompson TP, Flickinger JC, Dade L (2000) Brain metastases in patients with no known primary tumor. Cancer 89(5):1095\u20131101","journal-title":"Cancer"},{"issue":"3","key":"9947_CR23","first-page":"E7","volume":"22","author":"AL D\u2019Ambrosio","year":"2007","unstructured":"D\u2019Ambrosio AL, Agazzi S (2007) Prognosis in patients presenting with brain metastasis from an undiagnosed primary tumor. Neurosurg Focus 22(3):E7","journal-title":"Neurosurg Focus"},{"issue":"10","key":"9947_CR24","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2181::AID-CNCR17>3.0.CO;2-J","volume":"83","author":"LN Nguyen","year":"1998","unstructured":"Nguyen LN, Maor MH, Oswald MJ (1998) Brain metastases as the only manifestation of an undetected primary tumor. Cancer 83(10):2181\u20132184","journal-title":"Cancer"},{"key":"9947_CR25","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1471-2407-13-36","volume":"13","author":"M Riihimaki","year":"2013","unstructured":"Riihimaki M, Thomsen H, Hemminki A, Sundquist K, Hemminki K (2013) Comparison of survival of patients with metastases from known versus unknown primaries: survival in metastatic cancer. BMC Cancer 13:36","journal-title":"BMC Cancer"},{"issue":"11","key":"9947_CR26","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1158\/2159-8290.CD-15-0369","volume":"5","author":"PK Brastianos","year":"2015","unstructured":"Brastianos PK, Carter SL, Santagata S, Cahill DP, Taylor-Weiner A, Jones RT et al (2015) Genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets. Cancer Discov 5(11):1164\u20131177","journal-title":"Cancer Discov"},{"issue":"6","key":"9947_CR27","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1158\/2159-8290.CD-16-1396","volume":"7","author":"C Massard","year":"2017","unstructured":"Massard C, Michiels S, Ferte C, Le Deley MC, Lacroix L, Hollebecque A et al (2017) High-throughput genomics and clinical outcome in hard-to-treat advanced cancers: results of the MOSCATO 01 trial. Cancer Discov 7(6):586\u2013595","journal-title":"Cancer Discov"},{"issue":"5","key":"9947_CR28","doi-asserted-by":"publisher","first-page":"e000094","DOI":"10.1136\/esmoopen-2016-000094","volume":"1","author":"P Horak","year":"2016","unstructured":"Horak P, Frohling S, Glimm H (2016) Integrating next-generation sequencing into clinical oncology: strategies, promises and pitfalls. ESMO Open 1(5):e000094","journal-title":"ESMO Open"},{"issue":"2","key":"9947_CR29","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1093\/neuonc\/now241","volume":"19","author":"R Soffietti","year":"2017","unstructured":"Soffietti R, Abacioglu U, Baumert B, Combs SE, Kinhult S, Kros JM et al (2017) Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO). Neuro-oncology 19(2):162\u2013174","journal-title":"Neuro-oncology"},{"key":"9947_CR30","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ejca.2018.01.067","volume":"93","author":"A Levy","year":"2018","unstructured":"Levy A, Faivre-Finn C, Hasan B, De Maio E, Berghoff AS, Girard N et al (2018) Diversity of brain metastases screening and management in non-small cell lung cancer in Europe: Results of the European Organisation for Research and Treatment of Cancer Lung Cancer Group survey. Eur J Cancer 93:37\u201346","journal-title":"Eur J Cancer"},{"issue":"4","key":"9947_CR31","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s10147-018-1254-y","volume":"23","author":"T Ando","year":"2018","unstructured":"Ando T, Kage H, Saito M, Amano Y, Goto Y, Nakajima J et al (2018) Early stage non-small cell lung cancer patients need brain imaging regardless of symptoms. Int J Clin Oncol 23(4):641\u2013646","journal-title":"Int J Clin Oncol"}],"container-title":["Clinical &amp; Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10585-018-9947-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-018-9947-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-018-9947-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T19:07:09Z","timestamp":1573499229000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10585-018-9947-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,12]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["9947"],"URL":"https:\/\/doi.org\/10.1007\/s10585-018-9947-1","relation":{},"ISSN":["0262-0898","1573-7276"],"issn-type":[{"value":"0262-0898","type":"print"},{"value":"1573-7276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,12]]},"assertion":[{"value":"25 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}