{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:57:08Z","timestamp":1793761028997,"version":"4.6.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T00:00:00Z","timestamp":1569024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T00:00:00Z","timestamp":1569024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan society for the Promotion of Science","doi-asserted-by":"crossref","award":["17H04338"],"award-info":[{"award-number":["17H04338"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan society for the Promotion of Science","doi-asserted-by":"crossref","award":["16K15704"],"award-info":[{"award-number":["16K15704"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Metastasis"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s10585-019-09993-y","type":"journal-article","created":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T04:01:15Z","timestamp":1569038475000},"page":"145-158","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["CCL2 secreted from cancer-associated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway"],"prefix":"10.1007","volume":"37","author":[{"given":"Hiroaki","family":"Yasui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kajiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Tamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhisa","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kae","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitaka","family":"Kikkawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,21]]},"reference":[{"issue":"Suppl 5","key":"9993_CR1","doi-asserted-by":"crossref","first-page":"v23","DOI":"10.1093\/annonc\/mdq244","volume":"21","author":"N Colombo","year":"2010","unstructured":"Colombo N, Peiretti M, Parma G et al (2010) Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 21(Suppl 5):v23\u201330","journal-title":"Ann Oncol"},{"key":"9993_CR2","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1158\/1055-9965.EPI-16-0858","volume":"26","author":"LA Torre","year":"2017","unstructured":"Torre LA, Islami F, Siegel RL et al (2017) Global cancer in women: burden and trends. Cancer Epidemiol Biomark Prev 26:444\u2013457","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"9993_CR3","first-page":"1117","volume":"68","author":"Patient report from Gynecologic Oncology Committee","year":"2016","unstructured":"Patient report from Gynecologic Oncology Committee (2016) Acta obstetrica et gynaecologica. Japonica 68:1117\u20131160","journal-title":"Japonica"},{"key":"9993_CR4","first-page":"19","volume":"68","author":"F Kikkawa","year":"2006","unstructured":"Kikkawa F, Nawa A, Ino K et al (2006) Advances in treatment of epithelial ovarian cancer. Nagoya J Med Sci 68:19\u201326","journal-title":"Nagoya J Med Sci"},{"key":"9993_CR5","doi-asserted-by":"crossref","first-page":"e1000114","DOI":"10.1371\/journal.pmed.1000114","volume":"6","author":"PO Brown","year":"2009","unstructured":"Brown PO, Palmer C (2009) The preclinical natural history of serous ovarian cancer: defining the target for early detection. PLoS Med 6:e1000114","journal-title":"PLoS Med"},{"key":"9993_CR6","doi-asserted-by":"crossref","first-page":"e0194993","DOI":"10.1371\/journal.pone.0194993","volume":"13","author":"LC Chang","year":"2018","unstructured":"Chang LC, Huang CF, Lai MS et al (2018) Prognostic factors in epithelial ovarian cancer: a population-based study. PLoS One 13:e0194993","journal-title":"PLoS One"},{"key":"9993_CR7","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1148\/rg.233025105","volume":"23","author":"HK Pannu","year":"2003","unstructured":"Pannu HK, Bristow RE, Montz FJ, Fishman EK (2003) Multidetector CT of peritoneal carcinomatosis from ovarian cancer. Radiographics 23:687\u2013701","journal-title":"Radiographics"},{"key":"9993_CR8","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1001\/jama.2017.21926","volume":"319","author":"USPST Force","year":"2018","unstructured":"Force USPST, Grossman DC, Curry SJ et al (2018) Screening for ovarian cancer: US preventive services task force recommendation statement. JAMA 319:588\u2013594","journal-title":"JAMA"},{"key":"9993_CR9","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10555-012-9375-7","volume":"31","author":"Y Drabsch","year":"2012","unstructured":"Drabsch Y, ten Dijke P (2012) TGF-beta signalling and its role in cancer progression and metastasis. Cancer Metast Rev 31:553\u2013568","journal-title":"Cancer Metast Rev"},{"key":"9993_CR10","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nrc3603","volume":"13","author":"M Pickup","year":"2013","unstructured":"Pickup M, Novitskiy S, Moses HL (2013) The roles of TGFbeta in the tumour microenvironment. Nat Rev Cancer 13:788\u2013799","journal-title":"Nat Rev Cancer"},{"key":"9993_CR11","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/bjc.2013.768","volume":"110","author":"Y Yu","year":"2014","unstructured":"Yu Y, Xiao CH, Tan LD et al (2014) Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-beta signalling. Br J Cancer 110:724\u2013732","journal-title":"Br J Cancer"},{"key":"9993_CR12","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.1158\/0008-5472.CAN-10-0785","volume":"70","author":"E Giannoni","year":"2010","unstructured":"Giannoni E, Bianchini F, Masieri L et al (2010) Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res 70:6945\u20136956","journal-title":"Cancer Res"},{"key":"9993_CR13","first-page":"193","volume":"39","author":"K Fujikake","year":"2018","unstructured":"Fujikake K, Kajiyama H, Yoshihara M et al (2018) A novel mechanism of neovascularization in peritoneal dissemination via cancer-associated mesothelial cells affected by TGF-beta derived from ovarian cancer. Oncol Rep 39:193\u2013200","journal-title":"Oncol Rep"},{"key":"9993_CR14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00441-007-0455-x","volume":"330","author":"H Kajiyama","year":"2007","unstructured":"Kajiyama H, Shibata K, Ino K et al (2007) Possible involvement of SDF-1alpha\/CXCR4-DPPIV axis in TGF-beta1-induced enhancement of migratory potential in human peritoneal mesothelial cells. Cell Tissue Res 330:221\u2013229","journal-title":"Cell Tissue Res"},{"key":"9993_CR15","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1158\/1535-7163.MCT-14-0135","volume":"13","author":"K Sugiyama","year":"2014","unstructured":"Sugiyama K, Kajiyama H, Shibata K et al (2014) Expression of the miR200 family of microRNAs in mesothelial cells suppresses the dissemination of ovarian cancer cells. Mol Cancer Ther 13:2081\u20132091","journal-title":"Mol Cancer Ther"},{"key":"9993_CR16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.canlet.2016.05.022","volume":"379","author":"J Liu","year":"2016","unstructured":"Liu J, Chen S, Wang W et al (2016) Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-beta pathways. Cancer Lett 379:49\u201359","journal-title":"Cancer Lett"},{"key":"9993_CR17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fonc.2017.00024","volume":"7","author":"T Worzfeld","year":"2017","unstructured":"Worzfeld T, Pogge von Strandmann E, Huber M et al (2017) The unique molecular and cellular microenvironment of ovarian cancer. Front Oncol 7:24","journal-title":"Front Oncol"},{"key":"9993_CR18","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3390\/ijms15010361","volume":"15","author":"GG Muralidhar","year":"2013","unstructured":"Muralidhar GG, Barbolina MV (2013) Chemokine receptors in epithelial ovarian cancer. Int J Mol Sci 15:361\u2013376","journal-title":"Int J Mol Sci"},{"key":"9993_CR19","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.18632\/oncotarget.1426","volume":"4","author":"PJ Sarvaiya","year":"2013","unstructured":"Sarvaiya PJ, Guo D, Ulasov I et al (2013) Chemokines in tumor progression metastasis. Oncotarget 4:2171\u20132185","journal-title":"Oncotarget"},{"key":"9993_CR20","unstructured":"EssenBioScience-IncuCyte ZOOM live cell imaging."},{"key":"9993_CR21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1684\/ecn.2013.0340","volume":"24","author":"B Dobrzycka","year":"2013","unstructured":"Dobrzycka B, Mackowiak-Matejczyk B, Terlikowska KM et al (2013) Serum levels of IL-6, IL-8 and CRP as prognostic factors in epithelial ovarian cancer. Eur Cytokine Netw 24:106\u2013113","journal-title":"Eur Cytokine Netw"},{"key":"9993_CR22","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/bjc.2012.49","volume":"106","author":"A Popple","year":"2012","unstructured":"Popple A, Durrant LG, Spendlove I et al (2012) The chemokine, CXCL12, is an independent predictor of poor survival in ovarian cancer. Br J Cancer 106:1306\u20131313","journal-title":"Br J Cancer"},{"key":"9993_CR23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/1871530315666150316120920","volume":"15","author":"T O'Connor","year":"2015","unstructured":"O'Connor T, Borsig L, Heikenwalder M (2015) CCL2-CCR2 signaling in disease pathogenesis. Endocr Metab Immune Disord Drug Targets 15:105\u2013118","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"9993_CR24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/cmi.2015.106","volume":"14","author":"S Li","year":"2017","unstructured":"Li S, Lu J, Chen Y et al (2017) MCP-1-induced ERK\/GSK-3beta\/Snail signaling facilitates the epithelial-mesenchymal transition and promotes the migration of MCF-7 human breast carcinoma cells. Cell Mol Immunol 14:621\u2013630","journal-title":"Cell Mol Immunol"},{"key":"9993_CR25","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1016\/j.bbagen.2013.06.033","volume":"1830","author":"TH Lin","year":"2013","unstructured":"Lin TH, Liu HH, Tsai TH et al (2013) CCL2 increases alphavbeta3 integrin expression and subsequently promotes prostate cancer migration. Biochim Biophys Acta 1830:4917\u20134927","journal-title":"Biochim Biophys Acta"},{"key":"9993_CR26","first-page":"4785","volume":"33","author":"S Furukawa","year":"2013","unstructured":"Furukawa S, Soeda S, Kiko Y et al (2013) MCP-1 promotes invasion and adhesion of human ovarian cancer cells. Anticancer Res 33:4785\u20134790","journal-title":"Anticancer Res"},{"key":"9993_CR27","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00345-014-1389-z","volume":"33","author":"I Tsaur","year":"2015","unstructured":"Tsaur I, Rutz J, Makarevic J et al (2015) CCL2 promotes integrin-mediated adhesion of prostate cancer cells in vitro. World J Urol 33:1051\u20131056","journal-title":"World J Urol"},{"key":"9993_CR28","first-page":"e23816","volume":"2","author":"R Eferl","year":"2013","unstructured":"Eferl R (2013) CCL2 at the crossroad of cancer metastasis. JAKSTAT 2:e23816","journal-title":"JAKSTAT"},{"key":"9993_CR29","doi-asserted-by":"crossref","first-page":"36593","DOI":"10.1074\/jbc.M112.365999","volume":"287","author":"WB Fang","year":"2012","unstructured":"Fang WB, Jokar I, Zou A et al (2012) CCL2\/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 protein- and p42\/44 mitogen-activated protein kinase (MAPK)-dependent mechanisms. J Biol Chem 287:36593\u201336608","journal-title":"J Biol Chem"},{"key":"9993_CR30","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1158\/1541-7786.MCR-14-0303","volume":"13","author":"S He","year":"2015","unstructured":"He S, He S, Chen CH et al (2015) The chemokine (CCL2-CCR2) signaling axis mediates perineural invasion. Mol Cancer Res 13:380\u2013390","journal-title":"Mol Cancer Res"},{"key":"9993_CR31","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fonc.2018.00058","volume":"8","author":"J Chien","year":"2018","unstructured":"Chien J, Neums L, Powell A et al (2018) Genetic evidence for early peritoneal spreading in pelvic high-grade serous cancer. Front Oncol 8:58","journal-title":"Front Oncol"},{"key":"9993_CR32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12943-018-0787-z","volume":"17","author":"J Pasquier","year":"2018","unstructured":"Pasquier J, Gosset M, Geyl C et al (2018) CCL2\/CCL5 secreted by the stroma induce IL-6\/PYK2 dependent chemoresistance in ovarian cancer. Mol Cancer 17:47","journal-title":"Mol Cancer"},{"key":"9993_CR33","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1189\/jlb.0609385","volume":"86","author":"G Solinas","year":"2009","unstructured":"Solinas G, Germano G, Mantovani A, Allavena P (2009) Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol 86:1065\u20131073","journal-title":"J Leukoc Biol"},{"key":"9993_CR34","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1172\/JCI117933","volume":"95","author":"RP Negus","year":"1995","unstructured":"Negus RP, Stamp GW, Relf MG et al (1995) The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer. J Clin Invest 95:2391\u20132396","journal-title":"J Clin Invest"},{"key":"9993_CR35","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/sj.bjc.6690776","volume":"81","author":"L Hefler","year":"1999","unstructured":"Hefler L, Tempfer C, Heinze G et al (1999) Monocyte chemoattractant protein-1 serum levels in ovarian cancer patients. Br J Cancer 81:855\u2013859","journal-title":"Br J Cancer"},{"key":"9993_CR36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s12032-016-0810-4","volume":"33","author":"J Mikula-Pietrasik","year":"2016","unstructured":"Mikula-Pietrasik J, Uruski P, Szubert S et al (2016) Biochemical composition of malignant ascites determines high aggressiveness of undifferentiated ovarian tumors. Med Oncol 33:94","journal-title":"Med Oncol"},{"key":"9993_CR37","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1158\/0008-5472.CAN-11-3567","volume":"72","author":"A Tsuyada","year":"2012","unstructured":"Tsuyada A, Chow A, Wu J et al (2012) CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res 72:2768\u20132779","journal-title":"Cancer Res"},{"key":"9993_CR38","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1042\/BJ20071493","volume":"409","author":"M O'Hayre","year":"2008","unstructured":"O'Hayre M, Salanga CL, Handel TM, Allen SJ (2008) Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment. Biochem J 409:635\u2013649","journal-title":"Biochem J"},{"key":"9993_CR39","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1593\/neo.07871","volume":"10","author":"JC Pahler","year":"2008","unstructured":"Pahler JC, Tazzyman S, Erez N et al (2008) Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response. Neoplasia 10:329\u2013340","journal-title":"Neoplasia"},{"key":"9993_CR40","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.4161\/cbt.8.18.9285","volume":"8","author":"JM Green","year":"2009","unstructured":"Green JM, Alvero AB, Kohen F, Mor G (2009) 7-(O)-Carboxymethyl daidzein conjugated to N-t-Boc-hexylenediamine: a novel compound capable of inducing cell death in epithelial ovarian cancer stem cells. Cancer Biol Ther 8:1747\u20131753","journal-title":"Cancer Biol Ther"},{"key":"9993_CR41","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.3892\/ijo.2016.3678","volume":"49","author":"S Puvanenthiran","year":"2016","unstructured":"Puvanenthiran S, Essapen S, Seddon AM, Modjtahedi H (2016) Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of small molecule tyrosine kinase inhibitors and cytotoxic drugs. Int J Oncol 49:1825\u20131838","journal-title":"Int J Oncol"},{"key":"9993_CR42","doi-asserted-by":"crossref","first-page":"37714","DOI":"10.18632\/oncotarget.9265","volume":"7","author":"W Sun","year":"2016","unstructured":"Sun W, Li WJ, Wei FQ et al (2016) Blockade of MCP-1\/CCR4 signaling-induced recruitment of activated regulatory cells evokes an antitumor immune response in head and neck squamous cell carcinoma. Oncotarget 7:37714\u201337727","journal-title":"Oncotarget"},{"key":"9993_CR43","first-page":"4791","volume":"30","author":"AN Fader","year":"2010","unstructured":"Fader AN, Rasool N, Vaziri SA et al (2010) CCL2 expression in primary ovarian carcinoma is correlated with chemotherapy response and survival outcomes. Anticancer Res 30:4791\u20134798","journal-title":"Anticancer Res"},{"issue":"9","key":"9993_CR44","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/jog.13043","volume":"42","author":"Toshiaki Saito","year":"2016","unstructured":"Saito T, Katabuchi H (2016) Annual Report of the Committee on Gynecologic Oncology, Japan Society of Obstetrics and Gynecology: patient annual report for 2013 and treatment annual report for 2008. J Obstet Gynaecol Res 42: 1069\u20131079","journal-title":"Journal of Obstetrics and Gynaecology Research"},{"key":"9993_CR45","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ccr.2012.05.023","volume":"22","author":"MJ Wolf","year":"2012","unstructured":"Wolf MJ, Hoos A, Bauer J et al (2012) Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell 22:91\u2013105","journal-title":"Cancer Cell"},{"key":"9993_CR46","doi-asserted-by":"crossref","first-page":"805","DOI":"10.4049\/jimmunol.161.2.805","volume":"161","author":"M Mellado","year":"1998","unstructured":"Mellado M, Rodriguez-Frade JM, Aragay A et al (1998) The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J Immunol 161:805\u2013813","journal-title":"J Immunol"},{"key":"9993_CR47","first-page":"21","volume":"39","author":"H Zhuang","year":"2018","unstructured":"Zhuang H, Cao G, Kou C, Liu T (2018) CCL2\/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in vitro through activation of the Hedgehog pathway. Oncol Rep 39:21\u201330","journal-title":"Oncol Rep"}],"container-title":["Clinical &amp; Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-019-09993-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10585-019-09993-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-019-09993-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T16:14:56Z","timestamp":1695226496000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10585-019-09993-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,21]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["9993"],"URL":"https:\/\/doi.org\/10.1007\/s10585-019-09993-y","relation":{},"ISSN":["0262-0898","1573-7276"],"issn-type":[{"value":"0262-0898","type":"print"},{"value":"1573-7276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,21]]},"assertion":[{"value":"2 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}