{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:51:44Z","timestamp":1740124304008,"version":"3.37.3"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R03CA181893","R01CA174926","T32CA00923","P30CA023074"],"award-info":[{"award-number":["R03CA181893","R01CA174926","T32CA00923","P30CA023074"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008227","name":"Achievement Rewards for College Scientists Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008227","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012639","name":"METAvivor","doi-asserted-by":"publisher","award":["Translational Research Award"],"award-info":[{"award-number":["Translational Research Award"]}],"id":[{"id":"10.13039\/100012639","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Metastasis"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s10585-019-10012-3","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T11:02:44Z","timestamp":1576839764000},"page":"269-281","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Skeletal impact of 17\u03b2-estradiol in T cell-deficient mice: age-dependent bone effects and osteosarcoma formation"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3068-1196","authenticated-orcid":false,"given":"Julia N.","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer B.","family":"Frye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan A.","family":"Whitman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9826-5407","authenticated-orcid":false,"given":"Janet L.","family":"Funk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"10012_CR1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/joim.12084","volume":"274","author":"AJ Redig","year":"2013","unstructured":"Redig AJ, McAllister SS (2013) Breast cancer as a systemic disease: a view of metastasis. J Intern Med 274:113\u2013126. https:\/\/doi.org\/10.1111\/joim.12084","journal-title":"J Intern Med"},{"key":"10012_CR2","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1242\/dmm.028274","volume":"10","author":"I Holen","year":"2017","unstructured":"Holen I, Speirs V, Morrissey B, Blyth K (2017) In vivo models in breast cancer research: progress, challenges and future directions. Dis Model Mech 10:359\u2013371. https:\/\/doi.org\/10.1242\/dmm.028274","journal-title":"Dis Model Mech"},{"key":"10012_CR3","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/bonekey.2016.31","volume":"5","author":"LE Wright","year":"2016","unstructured":"Wright LE, Ottewell PD, Rucci N et al (2016) Murine models of breast cancer bone metastasis. BoneKEy Rep 5:804. https:\/\/doi.org\/10.1038\/bonekey.2016.31","journal-title":"BoneKEy Rep"},{"key":"10012_CR4","doi-asserted-by":"publisher","first-page":"R319","DOI":"10.1530\/ERC-18-0063","volume":"25","author":"BC \u00d6zdemir","year":"2018","unstructured":"\u00d6zdemir BC, Sflomos G, Brisken C (2018) The challenges of modeling hormone receptor-positive breast cancer in mice. Endocr Relat Cancer 25:R319\u2013R330. https:\/\/doi.org\/10.1530\/ERC-18-0063","journal-title":"Endocr Relat Cancer"},{"key":"10012_CR5","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1038\/MT.2012.73","volume":"20","author":"RA Morgan","year":"2012","unstructured":"Morgan RA (2012) Human tumor xenografts: the good, the bad, and the ugly. Mol Ther 20:882. https:\/\/doi.org\/10.1038\/MT.2012.73","journal-title":"Mol Ther"},{"key":"10012_CR6","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.1210\/en.2014-1890","volume":"156","author":"ME Nilsson","year":"2015","unstructured":"Nilsson ME, Vandenput L, Tivesten \u00c5 et al (2015) Measurement of a comprehensive sex steroid profile in rodent serum by high-sensitive gas chromatography-tandem mass spectrometry. Endocrinology 156:2492\u20132502. https:\/\/doi.org\/10.1210\/en.2014-1890","journal-title":"Endocrinology"},{"key":"10012_CR7","doi-asserted-by":"publisher","first-page":"R19","DOI":"10.1530\/JME-15-0310","volume":"57","author":"H Zhao","year":"2016","unstructured":"Zhao H, Zhou L, Shangguan AJ, Bulun SE (2016) Aromatase expression and regulation in breast and endometrial cancer. J Mol Endocrinol 57:R19\u201333. https:\/\/doi.org\/10.1530\/JME-15-0310","journal-title":"J Mol Endocrinol"},{"key":"10012_CR8","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1359\/jbmr.090208","volume":"24","author":"K Sj\u00f6gren","year":"2009","unstructured":"Sj\u00f6gren K, Lagerquist M, Moverare-Skrtic S et al (2009) Elevated aromatase expression in osteoblasts leads to increased bone mass without systemic adverse effects. J Bone Miner Res 24:1263\u20131270. https:\/\/doi.org\/10.1359\/jbmr.090208","journal-title":"J Bone Miner Res"},{"key":"10012_CR9","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/BF01612895","volume":"116","author":"P K\u00f6pf-Maier","year":"1990","unstructured":"K\u00f6pf-Maier P, Mboneko VF (1990) Anomalies in the hormonal status of athymic nude mice. J Cancer Res Clin Oncol 116:229\u2013231. https:\/\/doi.org\/10.1007\/BF01612895","journal-title":"J Cancer Res Clin Oncol"},{"key":"10012_CR10","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0022-4731(89)90079-4","volume":"34","author":"VC Jordan","year":"1989","unstructured":"Jordan VC, Gottardis MM, Robinson SP, Friedl A (1989) Immune-deficient animals to study \u201chormone-dependent\u201d breast and endometrial cancer. J Steroid Biochem 34:169\u2013176","journal-title":"J Steroid Biochem"},{"key":"10012_CR11","unstructured":"Noone AM, Howlader N, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ CK (2018) SEER Cancer Statistics Review, 1975\u20132015, National Cancer Institute. In: SEER Cancer Stat. Rev. 1975\u20132015, Natl. Cancer Institute. https:\/\/seer.cancer.gov\/csr\/1975_2015\/. Accessed 12 Apr 2018"},{"key":"10012_CR12","first-page":"584","volume":"45","author":"CK Osborne","year":"1985","unstructured":"Osborne CK, Hobbs K, Clark GM (1985) Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice. Cancer Res 45:584\u2013590","journal-title":"Cancer Res"},{"key":"10012_CR13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0304-3835(80)90097-X","volume":"11","author":"SM Shafie","year":"1980","unstructured":"Shafie SM, Liotta LA (1980) Formation of metastasis by human breast carcinoma cells (MCF-7) in nude mice. Cancer Lett 11:81\u201387","journal-title":"Cancer Lett"},{"key":"10012_CR14","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/0022-4731(88)90113-6","volume":"30","author":"MM Gottardis","year":"1988","unstructured":"Gottardis MM, Robinson SP, Jordan VC (1988) Estradiol-stimulated growth of MCF-7 tumors implanted in athymic mice: a model to study the tumoristatic action of tamoxifen. J Steroid Biochem 30:311\u2013314","journal-title":"J Steroid Biochem"},{"key":"10012_CR15","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1309\/AJCPYO5FSV3UPEXS","volume":"143","author":"A Soni","year":"2015","unstructured":"Soni A, Ren Z, Hameed O et al (2015) Breast cancer subtypes predispose the site of distant metastases. Am J Clin Pathol 143:471\u2013478. https:\/\/doi.org\/10.1309\/AJCPYO5FSV3UPEXS","journal-title":"Am J Clin Pathol"},{"key":"10012_CR16","doi-asserted-by":"publisher","first-page":"e2909","DOI":"10.1097\/MD.0000000000002909","volume":"95","author":"HH Han","year":"2016","unstructured":"Han HH, Lee SH, Kim BG et al (2016) Estrogen receptor status predicts late-onset skeletal recurrence in breast cancer patients. Medicine (Baltimore) 95:e2909. https:\/\/doi.org\/10.1097\/MD.0000000000002909","journal-title":"Medicine (Baltimore)"},{"key":"10012_CR17","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.steroids.2017.10.010","volume":"78","author":"B Winding","year":"2003","unstructured":"Winding B, Misander H, H\u00f8egh-Andersen P et al (2003) Estradiol enhances osteolytic lesions in mice inoculated with human estrogen receptor-negative MDA-231 breast cancer cells in vivo. Breast Cancer Res Treat 78:205\u2013216.\u00a0https:\/\/doi.org\/10.1016\/j.steroids.2017.10.010","journal-title":"Breast Cancer Res Treat"},{"key":"10012_CR18","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/J.STEROIDS.2017.10.010","volume":"142","author":"DJ Cohen","year":"2019","unstructured":"Cohen DJ, Patel V, Verma A, Schwartz Z (2019) Effect of 17\u03b2-estradiol on estrogen receptor negative breast cancer cells in an osteolytic mouse model. Steroids 142:28\u201333. https:\/\/doi.org\/10.1016\/J.STEROIDS.2017.10.010","journal-title":"Steroids"},{"key":"10012_CR19","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1002\/ijc.29439","volume":"137","author":"PD Ottewell","year":"2015","unstructured":"Ottewell PD, Wang N, Brown HK et al (2015) OPG-Fc inhibits ovariectomy-induced growth of disseminated breast cancer cells in bone. Int J Cancer 137:968\u2013977. https:\/\/doi.org\/10.1002\/ijc.29439","journal-title":"Int J Cancer"},{"key":"10012_CR20","doi-asserted-by":"publisher","first-page":"8406","DOI":"10.18632\/oncotarget.14139","volume":"8","author":"LE Wright","year":"2017","unstructured":"Wright LE, Harhash AA, Kozlow WM et al (2017) Aromatase inhibitor-induced bone loss increases the progression of estrogen receptor-negative breast cancer in bone and exacerbates muscle weakness in vivo. Oncotarget 8:8406\u20138419. https:\/\/doi.org\/10.18632\/oncotarget.14139","journal-title":"Oncotarget"},{"key":"10012_CR21","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.1210\/en.2005-0062","volume":"146","author":"SA Rabbani","year":"2005","unstructured":"Rabbani SA, Khalili P, Arakelian A et al (2005) Regulation of parathyroid hormone-related peptide by estradiol: effect on tumor growth and metastasis in vitro and in vivo. Endocrinology 146:2885\u20132894. https:\/\/doi.org\/10.1210\/en.2005-0062","journal-title":"Endocrinology"},{"key":"10012_CR22","doi-asserted-by":"publisher","first-page":"2922","DOI":"10.1158\/1078-0432.CCR-13-1246","volume":"20","author":"PD Ottewell","year":"2014","unstructured":"Ottewell PD, Wang N, Brown HK et al (2014) Zoledronic acid has differential antitumor activity in the pre- and postmenopausal bone microenvironment in vivo. Clin Cancer Res 20:2922\u20132932. https:\/\/doi.org\/10.1158\/1078-0432.CCR-13-1246","journal-title":"Clin Cancer Res"},{"key":"10012_CR23","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1186\/s13058-014-0489-4","volume":"16","author":"N Ogba","year":"2014","unstructured":"Ogba N, Manning NG, Bliesner BS et al (2014) Luminal breast cancer metastases and tumor arousal from dormancy are promoted by direct actions of estradiol and progesterone on the malignant cells. Breast Cancer Res 16:489. https:\/\/doi.org\/10.1186\/s13058-014-0489-4","journal-title":"Breast Cancer Res"},{"key":"10012_CR24","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s10549-012-2222-2","volume":"135","author":"J Canon","year":"2012","unstructured":"Canon J, Bryant R, Roudier M et al (2012) RANKL inhibition combined with tamoxifen treatment increases anti-tumor efficacy and prevents tumor-induced bone destruction in an estrogen receptor-positive breast cancer bone metastasis model. Breast Cancer Res Treat 135:771\u2013780. https:\/\/doi.org\/10.1007\/s10549-012-2222-2","journal-title":"Breast Cancer Res Treat"},{"key":"10012_CR25","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s10585-015-9770-x","volume":"33","author":"I Holen","year":"2015","unstructured":"Holen I, Walker M, Nutter F et al (2015) Oestrogen receptor positive breast cancer metastasis to bone: inhibition by targeting the bone microenvironment in vivo. Clin Exp Metastasis 33:211\u2013224. https:\/\/doi.org\/10.1007\/s10585-015-9770-x","journal-title":"Clin Exp Metastasis"},{"key":"10012_CR26","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s10585-012-9466-4","volume":"29","author":"V Ganapathy","year":"2012","unstructured":"Ganapathy V, Banach-Petrosky W, Xie W et al (2012) Luminal breast cancer metastasis is dependent on estrogen signaling. Clin Exp Metastasis 29:493\u2013509. https:\/\/doi.org\/10.1007\/s10585-012-9466-4","journal-title":"Clin Exp Metastasis"},{"key":"10012_CR27","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1038\/ncb3408","volume":"18","author":"RW Johnson","year":"2016","unstructured":"Johnson RW, Finger EC, Olcina MM et al (2016) Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol 18:1078\u20131089. https:\/\/doi.org\/10.1038\/ncb3408","journal-title":"Nat Cell Biol"},{"key":"10012_CR28","doi-asserted-by":"publisher","first-page":"14299","DOI":"10.1038\/s41598-018-32653-2","volume":"8","author":"ME Sowder","year":"2018","unstructured":"Sowder ME, Johnson RW (2018) Enrichment and detection of bone disseminated tumor cells in models of low tumor burden. Sci Rep 8:14299. https:\/\/doi.org\/10.1038\/s41598-018-32653-2","journal-title":"Sci Rep"},{"key":"10012_CR29","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1038\/s41388-018-0456-0","volume":"38","author":"Y Li","year":"2019","unstructured":"Li Y, Zhang H, Zhao Y et al (2019) A mandatory role of nuclear PAK4-LIFR axis in breast-to-bone metastasis of ER\u03b1-positive breast cancer cells. Oncogene 38:808\u2013821. https:\/\/doi.org\/10.1038\/s41388-018-0456-0","journal-title":"Oncogene"},{"key":"10012_CR30","doi-asserted-by":"publisher","first-page":"4451","DOI":"10.1210\/endo.140.10.7037","volume":"140","author":"RJ Thomas","year":"1999","unstructured":"Thomas RJ, Guise TA, Yin JJ et al (1999) Breast cancer cells interact with osteoblasts to support osteoclast formation. Endocrinology 140:4451\u20134458. https:\/\/doi.org\/10.1210\/endo.140.10.7037","journal-title":"Endocrinology"},{"key":"10012_CR31","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/s00223-010-9359-y","volume":"86","author":"MD Willinghamm","year":"2010","unstructured":"Willinghamm MD, Brodt MD, Lee KL et al (2010) Age-related changes in bone structure and strength in female and male BALB\/c mice. Calcif Tissue Int 86:470\u2013483. https:\/\/doi.org\/10.1007\/s00223-010-9359-y","journal-title":"Calcif Tissue Int"},{"key":"10012_CR32","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1359\/jbmr.070507","volume":"22","author":"V Glatt","year":"2007","unstructured":"Glatt V, Canalis E, Stadmeyer L, Bouxsein ML (2007) Age-related changes in trabecular architecture differ in female and male C57BL\/6J mice. J Bone Miner Res 22:1197\u20131207. https:\/\/doi.org\/10.1359\/jbmr.070507","journal-title":"J Bone Miner Res"},{"key":"10012_CR33","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1530\/eje.0.1510503","volume":"151","author":"UIL Modder","year":"2004","unstructured":"Modder UIL, Riggs BL, Spelsberg TC et al (2004) Dose-response of estrogen on bone versus the uterus in ovariectomized mice. Eur J Endocrinol 151:503\u2013510","journal-title":"Eur J Endocrinol"},{"key":"10012_CR34","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2106\/00004623-195032010-00014","volume":"32A","author":"MR Urist","year":"1950","unstructured":"Urist MR, Budy AM, McLean FC (1950) Endosteal-bone formation in estrogen-treated mice. J Bone Joint Surg 32A:143\u2013162\u00a0","journal-title":"J Bone Joint Surg"},{"key":"10012_CR35","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1359\/jbmr.2000.15.6.1126","volume":"15","author":"CH Turner","year":"2000","unstructured":"Turner CH, Hsieh Y-F, M\u00fcller R et al (2000) Genetic regulation of cortical and trabecular bone strength and microstructure in inbred strains of mice. J Bone Miner Res 15:1126\u20131131. https:\/\/doi.org\/10.1359\/jbmr.2000.15.6.1126","journal-title":"J Bone Miner Res"},{"key":"10012_CR36","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1359\/JBMR.050307","volume":"20","author":"ML Bouxsein","year":"2005","unstructured":"Bouxsein ML, Myers KS, Shultz KL et al (2005) Ovariectomy-induced bone loss varies among inbred strains of mice. J Bone Miner Res 20:1085\u20131092. https:\/\/doi.org\/10.1359\/JBMR.050307","journal-title":"J Bone Miner Res"},{"key":"10012_CR37","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1172\/JCI11066","volume":"106","author":"S Cenci","year":"2000","unstructured":"Cenci S, Weitzmann MN, Roggia C et al (2000) Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Investig 106:1229\u20131237. https:\/\/doi.org\/10.1172\/JCI11066","journal-title":"J Clin Investig"},{"key":"10012_CR38","doi-asserted-by":"publisher","first-page":"4443","DOI":"10.1210\/en.2011-1501","volume":"152","author":"DJ Haisenleder","year":"2011","unstructured":"Haisenleder DJ, Schoenfelder AH, Marcinko ES et al (2011) Estimation of estradiol in mouse serum samples: evaluation of commercial estradiol immunoassays. Endocrinology 152:4443\u20134447. https:\/\/doi.org\/10.1210\/en.2011-1501","journal-title":"Endocrinology"},{"key":"10012_CR39","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1021\/np300663v","volume":"76","author":"LE Wright","year":"2013","unstructured":"Wright LE, Frye JB, Lukefahr AL et al (2013) Curcuminoids block TGF-\u03b2 signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis. J Nat Prod 76:316\u2013321. https:\/\/doi.org\/10.1021\/np300663v","journal-title":"J Nat Prod"},{"key":"10012_CR40","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/jbmr.1805","volume":"28","author":"DW Dempster","year":"2013","unstructured":"Dempster DW, Compston JE, Drezner MK et al (2013) Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 28:2\u201317. https:\/\/doi.org\/10.1002\/jbmr.1805","journal-title":"J Bone Miner Res"},{"key":"10012_CR41","doi-asserted-by":"publisher","first-page":"6460","DOI":"10.1038\/s41598-017-06614-0","volume":"7","author":"C Streicher","year":"2017","unstructured":"Streicher C, Heyny A, Andrukhova O et al (2017) Estrogen regulates bone turnover by targeting rankl expression in bone lining cells. Sci Rep 7:6460. https:\/\/doi.org\/10.1038\/s41598-017-06614-0","journal-title":"Sci Rep"},{"key":"10012_CR42","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/J.PRP.2016.06.012","volume":"212","author":"I Machado","year":"2016","unstructured":"Machado I, Navarro S, Picci P, Llombart-Bosch A (2016) The utility of SATB2 immunohistochemical expression in distinguishing between osteosarcomas and their malignant bone tumor mimickers, such as Ewing sarcomas and chondrosarcomas. Pathol-Res Pract 212:811\u2013816. https:\/\/doi.org\/10.1016\/J.PRP.2016.06.012","journal-title":"Pathol-Res Pract"},{"key":"10012_CR43","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/his.12138","volume":"63","author":"JR Conner","year":"2013","unstructured":"Conner JR, Hornick JL (2013) SATB2 is a novel marker of osteoblastic differentiation in bone and soft tissue tumours. Histopathology 63:36\u201349. https:\/\/doi.org\/10.1111\/his.12138","journal-title":"Histopathology"},{"key":"10012_CR44","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1359\/jbmr.2001.16.2.214","volume":"16","author":"IP Braidman","year":"2001","unstructured":"Braidman IP, Hainey L, Batra G et al (2001) Localization of estrogen receptor \u03b2 protein expression in adult human bone. J Bone Miner Res 16:214\u2013220. https:\/\/doi.org\/10.1359\/jbmr.2001.16.2.214","journal-title":"J Bone Miner Res"},{"key":"10012_CR45","first-page":"4063","volume":"56","author":"G Mbalaviele","year":"1996","unstructured":"Mbalaviele G, Dunstan CR, Sasaki A et al (1996) E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model. Cancer Res 56:4063\u20134070","journal-title":"Cancer Res"},{"key":"10012_CR46","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1172\/JCI118947","volume":"98","author":"TA Guise","year":"1996","unstructured":"Guise TA, Yin JJ, Taylor SD et al (1996) Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Investig 98:1544\u20131549. https:\/\/doi.org\/10.1172\/JCI118947","journal-title":"J Clin Investig"},{"key":"10012_CR47","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S1535-6108(03)00132-6","volume":"3","author":"Y Kang","year":"2003","unstructured":"Kang Y, Siegel PM, Shu W et al (2003) A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3:537\u2013549. https:\/\/doi.org\/10.1016\/S1535-6108(03)00132-6","journal-title":"Cancer Cell"},{"key":"10012_CR48","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/8756-3282(93)90245-6","volume":"14","author":"A Odgaard","year":"1993","unstructured":"Odgaard A, Gundersen HJ (1993) Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions. Bone 14:173\u2013182","journal-title":"Bone"},{"key":"10012_CR49","doi-asserted-by":"publisher","first-page":"162","DOI":"10.3389\/fendo.2015.00162","volume":"6","author":"PL Salmon","year":"2015","unstructured":"Salmon PL, Ohlsson C, Shefelbine SJ, Doube M (2015) Structure model index does not measure rods and plates in trabecular bone. Front Endocrinol (Lausanne) 6:162. https:\/\/doi.org\/10.3389\/fendo.2015.00162","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10012_CR50","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1080\/01495739708936692","volume":"1","author":"T Hildebrand","year":"1997","unstructured":"Hildebrand T, R\u00fcegsegger P (1997) Quantification of bone microarchitecture with the structure model index. Comput Methods Biomech Biomed Engin 1:15\u201323. https:\/\/doi.org\/10.1080\/01495739708936692","journal-title":"Comput Methods Biomech Biomed Engin"},{"key":"10012_CR51","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1002\/jbmr.141","volume":"25","author":"ML Bouxsein","year":"2010","unstructured":"Bouxsein ML, Boyd SK, Christiansen BA et al (2010) Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res 25:1468\u20131486. https:\/\/doi.org\/10.1002\/jbmr.141","journal-title":"J Bone Miner Res"},{"key":"10012_CR52","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1016\/B978-0-323-35762-3.00160-8","volume-title":"Hematology: basic principles and practice","author":"NT Connell","year":"2018","unstructured":"Connell NT, Shurin SB, Schiffman F (2018) The spleen and its disorders. In: Hoffman R, Benz EJ, Silberstein LE et al (eds) Hematology: basic principles and practice, 7th edn. Elsevier, Philadelphia, PA, pp 2313\u20132327","edition":"7"},{"key":"10012_CR53","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1177\/0192623308329281","volume":"37","author":"G Pearse","year":"2009","unstructured":"Pearse G, Frith J, Randall KJ, Klinowska T (2009) Urinary retention and cystitis associated with subcutaneous estradiol pellets in female nude mice. Toxicol Pathol 37:227\u2013234. https:\/\/doi.org\/10.1177\/0192623308329281","journal-title":"Toxicol Pathol"},{"key":"10012_CR54","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1354\/vp.08-VP-0180-N-BC","volume":"46","author":"G Gakhar","year":"2009","unstructured":"Gakhar G, Wight-Carter M, Andrews G et al (2009) Hydronephrosis and urine retention in estrogen-implanted athymic nude mice. Vet Pathol 46:505\u2013508. https:\/\/doi.org\/10.1354\/vp.08-VP-0180-N-BC","journal-title":"Vet Pathol"},{"key":"10012_CR55","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/J.YGCEN.2011.11.014","volume":"175","author":"E Ingberg","year":"2012","unstructured":"Ingberg E, Theodorsson A, Theodorsson E, Strom JO (2012) Methods for long-term 17\u03b2-estradiol administration to mice. Gen Comp Endocrinol 175:188\u2013193. https:\/\/doi.org\/10.1016\/J.YGCEN.2011.11.014","journal-title":"Gen Comp Endocrinol"},{"key":"10012_CR56","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.bone.2018.04.007","volume":"112","author":"F-S Wang","year":"2018","unstructured":"Wang F-S, Wu R-W, Lain W-S et al (2018) Sclerostin vaccination mitigates estrogen deficiency induction of bone mass loss and microstructure deterioration. Bone 112:24\u201334. https:\/\/doi.org\/10.1016\/j.bone.2018.04.007","journal-title":"Bone"},{"key":"10012_CR57","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1002\/jbmr.3227","volume":"32","author":"P Panwar","year":"2017","unstructured":"Panwar P, Xue L, S\u00f8e K et al (2017) An ectosteric inhibitor of cathepsin k inhibits bone resorption in ovariectomized mice. J Bone Miner Res 32:2415\u20132430. https:\/\/doi.org\/10.1002\/jbmr.3227","journal-title":"J Bone Miner Res"},{"key":"10012_CR58","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1002\/jbmr.2142","volume":"29","author":"JR Hawse","year":"2014","unstructured":"Hawse JR, Pitel KS, Cicek M et al (2014) TGF\u03b2 inducible early gene-1 plays an important role in mediating estrogen signaling in the skeleton. J Bone Miner Res 29:1206\u20131216. https:\/\/doi.org\/10.1002\/jbmr.2142","journal-title":"J Bone Miner Res"},{"key":"10012_CR59","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/BF01623458","volume":"7","author":"P Ballanti","year":"1997","unstructured":"Ballanti P, Minisola S, Pacitti MT et al (1997) Tartrate-resistant acid phosphate activity as osteoclastic marker: sensitivity of cytochemical assessment and serum assay in comparison with standardized osteoclast histomorphometry. Osteoporos Int 7:39\u201343. https:\/\/doi.org\/10.1007\/BF01623458","journal-title":"Osteoporos Int"},{"key":"10012_CR60","first-page":"96","volume":"65","author":"KE O\u2019Connell","year":"2015","unstructured":"O\u2019Connell KE, Mikkola AM, Stepanek AM et al (2015) Practical murine hematopathology: a comparative review and implications for research. Comp Med 65:96","journal-title":"Comp Med"},{"key":"10012_CR61","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1677\/joe.0.1750319","volume":"175","author":"M Erlandsson","year":"2002","unstructured":"Erlandsson M, Jonsson C, Lindberg M et al (2002) Raloxifene- and estradiol-mediated effects on uterus, bone and B lymphocytes in mice. J Endocrinol 175:319\u2013327. https:\/\/doi.org\/10.1677\/joe.0.1750319","journal-title":"J Endocrinol"},{"key":"10012_CR62","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1600-0463.2005.apm_113502.x","volume":"113","author":"MC Erlandsson","year":"2005","unstructured":"Erlandsson MC, Islander U, Moverare S et al (2005) Estrogenic agonism and antagonism of the soy isoflavone genistein in uterus, bone and lymphopoiesis in mice. APMIS 113:317\u2013323. https:\/\/doi.org\/10.1111\/j.1600-0463.2005.apm_113502.x","journal-title":"APMIS"},{"key":"10012_CR63","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1182\/blood.V95.6.2059","volume":"95","author":"KL Medina","year":"2000","unstructured":"Medina KL, Strasser A, Kincade PW (2000) Estrogen influences the differentiation, proliferation, and survival of early B-lineage precursors. Blood 95:2059\u20132067","journal-title":"Blood"},{"key":"10012_CR64","volume-title":"Yen and Jaffe\u2019s reproductive endocrinology: physiology, pathophysiology, and clinical management","author":"JF Strauss","year":"2019","unstructured":"Strauss JF, Barbieri RL, Yen SSC (2019) Yen and Jaffe\u2019s reproductive endocrinology: physiology, pathophysiology, and clinical management, 8th edn. Elsevier, Philadelphia, PA","edition":"8"},{"key":"10012_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10911-016-9368-1","volume":"22","author":"C G\u00e9rard","year":"2017","unstructured":"G\u00e9rard C, Gallez A, Dubois C et al (2017) Accurate control of 17\u03b2-estradiol long-term release increases reliability and reproducibility of preclinical animal studies. J Mammary Gland Biol Neoplasia 22:1\u201311. https:\/\/doi.org\/10.1007\/s10911-016-9368-1","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"10012_CR66","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1097\/NOR.0b013e3182879bbb","volume":"32","author":"K Haynes","year":"2013","unstructured":"Haynes K, Tyner C, Williams PD (2013) Repiphysis prosthesis for limb preservation in pediatric patients with bone cancer: a literature review. Orthop Nurs 32:81\u201386. https:\/\/doi.org\/10.1097\/NOR.0b013e3182879bbb","journal-title":"Orthop Nurs"},{"key":"10012_CR67","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/os.12237","volume":"8","author":"Y Chen","year":"2016","unstructured":"Chen Y, Yu X, Xu S et al (2016) Impacts of tumor location, nature and bone destruction of extremity osteosarcoma on selection of limb salvage operative procedure. Orthop Surg 8:139\u2013149. https:\/\/doi.org\/10.1111\/os.12237","journal-title":"Orthop Surg"},{"key":"10012_CR68","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1093\/jnci\/67.3.653","volume":"67","author":"B Highman","year":"1981","unstructured":"Highman B, Roth SI, Greenman DL (1981) Osseous changes and osteosarcomas in mice continuously fed diets containing diethylstilbestrol or 17\u03b2-estradiol. J Natl Cancer Inst 67:653\u2013662. https:\/\/doi.org\/10.1093\/jnci\/67.3.653","journal-title":"J Natl Cancer Inst"},{"key":"10012_CR69","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1080\/01926230490462138","volume":"32","author":"JL Vahle","year":"2004","unstructured":"Vahle JL, Long GG, Sandusky G et al (2004) Bone neoplasms in f344 rats given teriparatide [rhPTH(1-34)] are dependent on duration of treatment and dose. Toxicol Pathol 32:426\u2013438. https:\/\/doi.org\/10.1080\/01926230490462138","journal-title":"Toxicol Pathol"},{"key":"10012_CR70","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1080\/01926230252929882","volume":"30","author":"JL Vahle","year":"2002","unstructured":"Vahle JL, Sato M, Long GG et al (2002) Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1\u201334) for 2 years and relevance to human safety. Toxicol Pathol 30:312\u2013321. https:\/\/doi.org\/10.1080\/01926230252929882","journal-title":"Toxicol Pathol"}],"container-title":["Clinical & Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-019-10012-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10585-019-10012-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-019-10012-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:10:21Z","timestamp":1608336621000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10585-019-10012-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,20]]},"references-count":70,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10012"],"URL":"https:\/\/doi.org\/10.1007\/s10585-019-10012-3","relation":{},"ISSN":["0262-0898","1573-7276"],"issn-type":[{"type":"print","value":"0262-0898"},{"type":"electronic","value":"1573-7276"}],"subject":[],"published":{"date-parts":[[2019,12,20]]},"assertion":[{"value":"13 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}