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HAI catheter systems were implanted under the guide of digital subtract angiography (DSA) in 16 patients with unresectable nasopharyngeal carcinoma liver metastases. HAI gemcitabine and FUDR in combination with radiotherapy and systemic chemotherapy were delivered. Disease control rate (DCR) of intrahepatic lesions is 100%, objective response rate (ORR) of intrahepatic lesions is 87.5%, including 4 patients (25%) with complete response (CR), 10 patients (62.5%) with partial response (PR) and 2 patients (12.5%) with stable disease (SD). The median overall survival (mOS) was 30\u00a0months. There was no significant difference between patients with &lt; 9 intrahepatic lesions and patients with\u2009\u2265\u20099 intrahepatic lesions (31\u00a0months vs. 24\u00a0months, <jats:italic>P<\/jats:italic>\u2009=\u20090.562). Patients without extrahepatic metastases has longer survival than patients with extrahepatic metastases (31\u00a0months vs. 17\u00a0months, <jats:italic>P<\/jats:italic>\u2009=\u20090.005). In all 72 cycles of HAI, the main grade 3\/4 toxicities related to HAI include: leukopenia occur in 8 cycles (11.1%), thrombocytopenia in 5 cycles (6.9%), AST\/ALT elevation in 12 cycles (16.7). Catheter related complications occurred in 2 patients (12.5%). HAI gemcitabine and FUDR is effective to improve DCR of intrahepatic lesions and prolong mOS for patients with nasopharyngeal carcinoma liver metastases, and is associated with a relative low rate of toxicity.<\/jats:p>","DOI":"10.1007\/s10585-019-10015-0","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T11:02:44Z","timestamp":1576839764000},"page":"333-339","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hepatic artery infusion pump for nasopharyngeal carcinoma with liver metastasis"],"prefix":"10.1007","volume":"37","author":[{"given":"Changli","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0346-7402","authenticated-orcid":false,"given":"Liangrong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"issue":"7","key":"10015_CR1","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1093\/jjco\/hyw046","volume":"46","author":"Y Si","year":"2016","unstructured":"Si Y, Lan G, Deng Z et al (2016) Distribution and clinical significance of circulating tumor cells in nasopharyngeal carcinoma. 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