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Affected patients are often treated by decompressive laminectomy. To assess the impact of this procedure on Karnofsky Performance Index (KPI) and Frankel Grade (FG) at discharge, a single center retrospective cohort study of neurologically impaired MSCC-patients treated with decompressive laminectomy between 2004 and 2014 was performed. 101 patients (27 female\/74 male; age 66.1\u2009\u00b1\u200911.5\u00a0years) were identified. Prostate was the most common primary tumor site (40%) and progressive disease was present in 74%. At admission, 80% of patients were non-ambulatory (FG A\u2013C). Imaging revealed prevalently thoracic MSCC (78%). Emergency surgery (&lt;\u200924\u00a0h) was performed in 71% and rates of complications and revision surgery were 6% and 4%, respectively. At discharge, FG had improved in 61% of cases, and 51% of patients had regained ambulation. Univariate predictors for not regaining the ability to walk were bowl dysfunction (p\u2009=\u20090.0015), KPI\u2009&lt;\u200950% (p\u2009=\u20090.048) and FG\u2009&lt;\u2009C (p\u2009=\u20090.001) prior to surgery. In conclusion, decompressive laminectomy showed beneficial effects on the functional outcome at discharge. A good neurological status prior to surgery was key predictor for a good functional outcome.<\/jats:p>","DOI":"10.1007\/s10585-019-10016-z","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T16:02:37Z","timestamp":1579536157000},"page":"377-390","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Impact of decompressive laminectomy on the functional outcome of patients with metastatic spinal cord compression and neurological impairment"],"prefix":"10.1007","volume":"37","author":[{"given":"Alexander","family":"Younsi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Riemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Unterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Zweckberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"10016_CR1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/1097-0142(1950)3:1<74::AID-CNCR2820030111>3.0.CO;2-7","volume":"3","author":"HL Abrams","year":"1950","unstructured":"Abrams HL, Spiro R, Goldstein N (1950) Metastases in carcinoma; analysis of 1000 autopsied cases. 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