{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:57:30Z","timestamp":1778943450744,"version":"3.51.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Intramural Research Projects (ZIA). Project #1ZIASC000892-33"],"award-info":[{"award-number":["Intramural Research Projects (ZIA). Project #1ZIASC000892-33"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Intramural Research Projects (ZIA). Project #1ZIASC000892-33"],"award-info":[{"award-number":["Intramural Research Projects (ZIA). Project #1ZIASC000892-33"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Metastasis"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s10585-022-10182-7","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T13:03:11Z","timestamp":1659963791000},"page":"815-831","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems"],"prefix":"10.1007","volume":"39","author":[{"given":"Imran","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brunilde","family":"Gril","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayuko","family":"Hoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard H.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxwell P.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Difilippantonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Lyden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia S.","family":"Steeg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"issue":"4","key":"10182_CR1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nrc.2016.25","volume":"16","author":"PS Steeg","year":"2016","unstructured":"Steeg PS (2016) Targeting metastasis. Nat Rev Cancer 16(4):201\u2013218","journal-title":"Nat Rev Cancer"},{"issue":"4497","key":"10182_CR2","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1126\/science.7195067","volume":"212","author":"HF Dvorak","year":"1981","unstructured":"Dvorak HF et al (1981) Tumor shedding and coagulation. Science 212(4497):923\u2013924","journal-title":"Science"},{"issue":"1","key":"10182_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/j.1365-2141.1971.tb03416.x","volume":"21","author":"N Crawford","year":"1971","unstructured":"Crawford N (1971) The presence of contractile proteins in platelet microparticles isolated from human and animal platelet-free plasma. Br J Haematol 21(1):53\u201369","journal-title":"Br J Haematol"},{"key":"10182_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0991-5","author":"L Mashouri","year":"2019","unstructured":"Mashouri L et al (2019) Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance. Mol Cancer. https:\/\/doi.org\/10.1186\/s12943-019-0991-5","journal-title":"Mol Cancer"},{"key":"10182_CR5","first-page":"455","volume":"2","author":"L Zhang","year":"1871","unstructured":"Zhang L (1871) Yu DH (2019) Exosomes in cancer development, metastasis, and immunity. Biochimica Et Biophysica Acta-Rev Cancer 2:455\u2013468","journal-title":"Biochimica Et Biophysica Acta-Rev Cancer"},{"issue":"6","key":"10182_CR6","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/nm.2753","volume":"18","author":"H Peinado","year":"2012","unstructured":"Peinado H et al (2012) Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 18(6):883\u2013891","journal-title":"Nat Med"},{"issue":"11","key":"10182_CR7","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/s41556-019-0404-4","volume":"21","author":"G Rodrigues","year":"2019","unstructured":"Rodrigues G et al (2019) Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Nat Cell Biol 21(11):1403\u20131412","journal-title":"Nat Cell Biol"},{"issue":"6","key":"10182_CR8","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/ncb3169","volume":"17","author":"B Costa-Silva","year":"2015","unstructured":"Costa-Silva B et al (2015) Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat Cell Biol 17(6):816\u2013826","journal-title":"Nat Cell Biol"},{"key":"10182_CR9","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005231","author":"M Ono","year":"2014","unstructured":"Ono M et al (2014) Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells. Sci Signal. https:\/\/doi.org\/10.1126\/scisignal.2005231","journal-title":"Sci Signal"},{"key":"10182_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15016","author":"HY Zhang","year":"2017","unstructured":"Zhang HY et al (2017) Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis. Nat Commun. https:\/\/doi.org\/10.1038\/ncomms15016","journal-title":"Nat Commun"},{"issue":"7578","key":"10182_CR11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nature15756","volume":"527","author":"A Hoshino","year":"2015","unstructured":"Hoshino A et al (2015) Tumour exosome integrins determine organotropic metastasis. Nature 527(7578):329\u2013335","journal-title":"Nature"},{"issue":"6","key":"10182_CR12","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.21873\/anticanres.15063","volume":"41","author":"H Ichikawa","year":"2021","unstructured":"Ichikawa H et al (2021) Exosome transfer between pancreatic-cancer cells is associated with metastasis in a nude-mouse model. Anticancer Res 41(6):2829\u20132834","journal-title":"Anticancer Res"},{"key":"10182_CR13","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.canlet.2020.01.005","volume":"474","author":"D Wang","year":"2020","unstructured":"Wang D et al (2020) Exosome-encapsulated miRNAs contribute to CXCL12\/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophages. Cancer Lett 474:36\u201352","journal-title":"Cancer Lett"},{"key":"10182_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120224","author":"KY Wang","year":"2020","unstructured":"Wang KY et al (2020) An exosome-like programmable-bioactivating paclitaxel prodrug nanoplatform for enhanced breast cancer metastasis inhibition. Biomaterial. https:\/\/doi.org\/10.1016\/j.biomaterials.2020.120224","journal-title":"Biomaterial"},{"issue":"3","key":"10182_CR15","doi-asserted-by":"publisher","first-page":"5338","DOI":"10.3390\/ijms14035338","volume":"14","author":"C Corrado","year":"2013","unstructured":"Corrado C et al (2013) Exosomes as intercellular signaling organelles involved in health and disease: basic science and clinical applications. Int J Mol Sci 14(3):5338\u20135366","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10182_CR16","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.bbrc.2014.02.007","volume":"445","author":"K Shimbo","year":"2014","unstructured":"Shimbo K et al (2014) Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration. Biochem Biophys Res Commun 445(2):381\u2013387","journal-title":"Biochem Biophys Res Commun"},{"issue":"12 suppl","key":"10182_CR17","doi-asserted-by":"publisher","first-page":"S318","DOI":"10.1177\/09603271211041997","volume":"40","author":"G Mao","year":"2021","unstructured":"Mao G, Mu Z, Wu D (2021) Exosome-derived miR-2682\u20135p suppresses cell viability and migration by HDAC1-silence-mediated upregulation of ADH1A in non-small cell lung cancer. Hum Exp Toxicol 40(12 suppl):S318\u2013S330. https:\/\/doi.org\/10.1177\/09603271211041997","journal-title":"Hum Exp Toxicol"},{"key":"10182_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.760748","author":"D Shang","year":"2022","unstructured":"Shang D, Liu Y, Chen Z (2022) Exosome-transmitted miR-128 targets CCL18 to inhibit the proliferation and metastasis of urothelial carcinoma. Frontiers Mol Biosci. https:\/\/doi.org\/10.3389\/fmolb.2021.760748","journal-title":"Frontiers Mol Biosci"},{"issue":"4","key":"10182_CR19","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.bioactmat.2020.09.014","volume":"6","author":"CX Feng","year":"2021","unstructured":"Feng CX et al (2021) Folic acid-modified Exosome-PH20 enhances the efficiency of therapy via modulation of the tumor microenvironment and directly inhibits tumor cell metastasis. Bioactive Mater 6(4):963\u2013974","journal-title":"Bioactive Mater"},{"key":"10182_CR20","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1093\/jnci\/80.3.200","volume":"80","author":"PS Steeg","year":"1988","unstructured":"Steeg PS et al (1988) Evidence for a novel gene associated with low tumor metastatic potential. J Nat\u2019l Cancer Inst 80:200\u2013204","journal-title":"J Nat'l Cancer Inst"},{"issue":"3","key":"10182_CR21","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1023\/A:1005597231776","volume":"32","author":"MT Hartsough","year":"2000","unstructured":"Hartsough MT, Steeg PS (2000) Nm23\/nucleoside diphosphate kinase in human cancers. J Bioenerg Biomembr 32(3):301\u2013308","journal-title":"J Bioenerg Biomembr"},{"key":"10182_CR22","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0092-8674(91)90404-M","volume":"65","author":"A Leone","year":"1991","unstructured":"Leone A et al (1991) Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell 65:25\u201335","journal-title":"Cell"},{"key":"10182_CR23","first-page":"2325","volume":"8","author":"A Leone","year":"1993","unstructured":"Leone A et al (1993) Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: Effects on tumor metastatic potential, colonization, and enzymatic activity. Oncogene 8:2325\u20132333","journal-title":"Oncogene"},{"key":"10182_CR24","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/ijc.2910600213","volume":"60","author":"RS Parhar","year":"1995","unstructured":"Parhar RS et al (1995) Effects of cytokine mediated modulation of Nm23 expression on the invasion and metastatic behavior of B16F10 melanoma cells. Int J Cancer 60:204\u2013210","journal-title":"Int J Cancer"},{"key":"10182_CR25","first-page":"4301","volume":"5","author":"H Miyazaki","year":"1999","unstructured":"Miyazaki H et al (1999) Overexpression of nm23-H2\/NDP Kinase B in a human oral squamous cell carcinoma cell line results in reduced metastasis, differentiated phenotype in the metastatic site, and growth factor-independent proliferative activity in culture. ClinCancer Res 5:4301\u20134307","journal-title":"ClinCancer Res"},{"key":"10182_CR26","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s00432-001-0314-1","volume":"128","author":"F Liu","year":"2002","unstructured":"Liu F et al (2002) Transfection of the nm23-H1 gene into human hepatocarcinoma cell line inhibits the expression of sialyl Lewis X, a1,3 fucosyltransferase VII, and metastatic potential. J Cancer Res Clin Oncol 128:189\u2013196","journal-title":"J Cancer Res Clin Oncol"},{"issue":"6","key":"10182_CR27","first-page":"530","volume":"53","author":"G Che","year":"2006","unstructured":"Che G et al (2006) Transfection of nm23-H1 increased expression of beta-Catenin, E-cadherin and TIMP-1 and decreased the expression of MMP-2, CD44v6 and VEGF and inhibited the metastatic potential of human non-small cell lung cancer cell line L9981. Neoplasma 53(6):530\u2013537","journal-title":"Neoplasma"},{"issue":"23","key":"10182_CR28","doi-asserted-by":"publisher","first-page":"7216","DOI":"10.1158\/0008-5472.CAN-11-2015","volume":"71","author":"J Lim","year":"2011","unstructured":"Lim J et al (2011) Cell-permeable NM23 Blocks the maintenance and progression of established pulmonary metastasis. Can Res 71(23):7216\u20137225","journal-title":"Can Res"},{"issue":"1","key":"10182_CR29","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1759-7714.2012.00140.x","volume":"4","author":"Y Fan","year":"2013","unstructured":"Fan Y et al (2013) nm23-H1 gene driven by hTERT promoter induces inhibition of invasive phenotype and metastasis of lung cancer xenograft in mice. Thoracic Cancer 4(1):41\u201352","journal-title":"Thoracic Cancer"},{"issue":"1","key":"10182_CR30","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10585-012-9495-z","volume":"30","author":"SG Jarrett","year":"2013","unstructured":"Jarrett SG et al (2013) NM23 deficiency promotes metastasis in a UV radiation-induced mouse model of human melanoma. Clin Exp Metas 30(1):25\u201336","journal-title":"Clin Exp Metas"},{"issue":"6","key":"10182_CR31","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1182\/blood.V91.6.1845","volume":"91","author":"A Yokoyama","year":"1998","unstructured":"Yokoyama A et al (1998) Evaluation by multivariate analysis of the differentiation inhibitory factor nm23 as a prognostic factor in acute myelogenous leukemia and application to other hematologic malignancies. Blood 91(6):1845\u20131851","journal-title":"Blood"},{"key":"10182_CR32","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0012-1606(88)90170-4","volume":"129","author":"C Dearolf","year":"1988","unstructured":"Dearolf C, Hersperger E, Shearn A (1988) Developmental consequences of awdb3, a cell autonomous lethal mutation of Drosophila induced by hybrid dysgenesis. Dev Biol 129:159\u2013168","journal-title":"Dev Biol"},{"issue":"17","key":"10182_CR33","doi-asserted-by":"publisher","first-page":"4679","DOI":"10.1128\/MCB.00297-09","volume":"29","author":"JA Woolworth","year":"2009","unstructured":"Woolworth JA, Nallamothu G, Hsu T (2009) The drosophila metastasis suppressor gene Nm23 homolog, awd, regulates epithelial integrity during oogenesis. Mol Cell Biol 29(17):4679\u20134690","journal-title":"Mol Cell Biol"},{"issue":"22","key":"10182_CR34","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1101\/gad.1096903","volume":"17","author":"V Dammai","year":"2003","unstructured":"Dammai V et al (2003) Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi\/dynamin during tracheal development. Genes Dev 17(22):2812\u20132824","journal-title":"Genes Dev"},{"key":"10182_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-12-12","author":"M Ignesti","year":"2014","unstructured":"Ignesti M et al (2014) Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23. BMC Biol. https:\/\/doi.org\/10.1186\/1741-7007-12-12","journal-title":"BMC Biol"},{"issue":"6","key":"10182_CR36","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1128\/MCB.01743-07","volume":"28","author":"G Nallamothu","year":"2008","unstructured":"Nallamothu G et al (2008) awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion. Mol Cell Biol 28(6):1964\u20131973","journal-title":"Mol Cell Biol"},{"issue":"6191","key":"10182_CR37","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1126\/science.1253768","volume":"344","author":"M Boissan","year":"2014","unstructured":"Boissan M et al (2014) Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling. Science 344(6191):1510\u20131515","journal-title":"Science"},{"issue":"18","key":"10182_CR38","doi-asserted-by":"publisher","first-page":"4689","DOI":"10.1158\/0008-5472.CAN-19-0492","volume":"79","author":"I Khan","year":"2019","unstructured":"Khan I, Gril B, Steeg PS (2019) Metastasis suppressors NME1 and NME2 promote dynamin 2 oligomerization and regulate tumor cell endocytosis, motility, and metastasis. Can Res 79(18):4689\u20134702","journal-title":"Can Res"},{"issue":"11","key":"10182_CR39","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1007\/s00210-016-1268-9","volume":"389","author":"P Romani","year":"2016","unstructured":"Romani P et al (2016) Dynamin controls extracellular level of Awd\/Nme1 metastasis suppressor protein. Naunyn-Schmiedebergs Arch Pharmacol 389(11):1171\u20131182","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"issue":"2","key":"10182_CR40","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/labinvest.2017.102","volume":"98","author":"P Romani","year":"2018","unstructured":"Romani P et al (2018) Extracellular NME proteins: a player or a bystander? Lab Invest 98(2):248\u2013257","journal-title":"Lab Invest"},{"issue":"5","key":"10182_CR41","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/s41374-017-0012-5","volume":"98","author":"CM Bunce","year":"2018","unstructured":"Bunce CM, Khanim FL (2018) The \u201cknown-knowns\u201d, and \u201cknown-unknowns\u201d of extracellular Nm23-H1\/NDPK proteins. Lab Invest 98(5):602\u2013608","journal-title":"Lab Invest"},{"issue":"3","key":"10182_CR42","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/73432","volume":"24","author":"DT Ross","year":"2000","unstructured":"Ross DT et al (2000) Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet 24(3):227\u2013235","journal-title":"Nat Genet"},{"issue":"13","key":"10182_CR43","doi-asserted-by":"publisher","first-page":"5292","DOI":"10.1158\/0008-5472.CAN-09-1528","volume":"69","author":"AF Chambers","year":"2009","unstructured":"Chambers AF (2009) MDA-MB-435 and M14 cell lines: identical but not M14 melanoma? Cancer Res 69(13):5292\u20135293","journal-title":"Cancer Res"},{"issue":"15","key":"10182_CR44","doi-asserted-by":"publisher","first-page":"7238","DOI":"10.1158\/0008-5472.CAN-07-0962","volume":"67","author":"CE Horak","year":"2007","unstructured":"Horak CE et al (2007) Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2. Cancer Res 67(15):7238\u20137246","journal-title":"Cancer Res"},{"issue":"11","key":"10182_CR45","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1002\/pmic.200601024","volume":"7","author":"M Chevallet","year":"2007","unstructured":"Chevallet M et al (2007) Toward a better analysis of secreted proteins: the example of the myeloid cells secretome. Proteomics 7(11):1757\u20131770","journal-title":"Proteomics"},{"issue":"3","key":"10182_CR46","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.devcel.2019.04.011","volume":"49","author":"I Wortzel","year":"2019","unstructured":"Wortzel I et al (2019) Exosome-mediated metastasis: communication from a distance. Dev Cell 49(3):347\u2013360","journal-title":"Dev Cell"},{"issue":"3","key":"10182_CR47","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1034\/j.1600-0854.2000.010307.x","volume":"1","author":"M Babst","year":"2000","unstructured":"Babst M et al (2000) Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Traffic 1(3):248\u2013258","journal-title":"Traffic"},{"issue":"9","key":"10182_CR48","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1097\/WNR.0b013e3283383467","volume":"21","author":"S Okabayashi","year":"2010","unstructured":"Okabayashi S, Kimura N (2010) LGI3 interacts with flotillin-1 to mediate APP trafficking and exosome formation. NeuroReport 21(9):606\u2013610","journal-title":"NeuroReport"},{"issue":"1","key":"10182_CR49","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/ncb2000","volume":"12","author":"M Ostrowski","year":"2010","unstructured":"Ostrowski M et al (2010) Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol 12(1):19\u201330","journal-title":"Nat Cell Biol"},{"issue":"13","key":"10182_CR50","doi-asserted-by":"publisher","first-page":"5225","DOI":"10.1007\/s00018-021-03850-6","volume":"78","author":"BY Yang","year":"2021","unstructured":"Yang BY et al (2021) Recent advances in liposome formulations for breast cancer therapeutics. Cell Mol Life Sci 78(13):5225\u20135243","journal-title":"Cell Mol Life Sci"},{"issue":"11","key":"10182_CR51","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1093\/carcin\/bgw091","volume":"37","author":"YR Jung","year":"2016","unstructured":"Jung YR et al (2016) Silencing of ST6Gal I enhances colorectal cancer metastasis by down-regulating KAI1 via exosome-mediated exportation and thereby rescues integrin signaling. Carcinogenesis 37(11):1089\u20131097","journal-title":"Carcinogenesis"},{"issue":"10","key":"10182_CR52","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1111\/j.1349-7006.2009.01276.x","volume":"100","author":"J Okabe-Kado","year":"2009","unstructured":"Okabe-Kado J et al (2009) Extracellular NM23 protein promotes the growth and survival of primary cultured human acute myelogenous leukemia cells. Cancer Sci 100(10):1885\u20131894","journal-title":"Cancer Sci"},{"key":"10182_CR53","unstructured":"Anzinger J, et al (2001) Secretion of a nucleoside diphosphate kinase (Nm23-H2) by cells from human breast, colon, pancreas and lung tumors. 44th Annual Meeting of the Western-Pharmacology-Society, Vancouver, Canada Mar 25\u201329 Proceedings of the Western Pharmacology Society. Vol.44, pp 61\u20133"},{"issue":"10","key":"10182_CR54","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1038\/bjc.2011.134","volume":"104","author":"N Yokdang","year":"2011","unstructured":"Yokdang N et al (2011) A role for nucleotides in support of breast cancer angiogenesis: heterologous receptor signalling. Br J Cancer 104(10):1628\u20131640","journal-title":"Br J Cancer"},{"issue":"3","key":"10182_CR55","first-page":"847","volume":"32","author":"G Palazzolo","year":"2012","unstructured":"Palazzolo G et al (2012) Proteomic analysis of exosome-like vesicles derived from breast cancer cells. Anticancer Res 32(3):847\u2013860","journal-title":"Anticancer Res"},{"key":"10182_CR56","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-44","author":"S Kruger","year":"2014","unstructured":"Kruger S et al (2014) Molecular characterization of exosome-like vesicles from breast cancer cells. BMC Cancer. https:\/\/doi.org\/10.1186\/1471-2407-14-44","journal-title":"BMC Cancer"},{"issue":"16","key":"10182_CR57","doi-asserted-by":"publisher","first-page":"4828","DOI":"10.1158\/0008-5472.CAN-15-2831","volume":"76","author":"JA Menard","year":"2016","unstructured":"Menard JA et al (2016) Metastasis stimulation by hypoxia and acidosis-induced extracellular lipid uptake is mediated by proteoglycan-dependent endocytosis. Cancer Res 76(16):4828\u20134840","journal-title":"Cancer Res"},{"key":"10182_CR58","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.136215","author":"YJ Li","year":"2020","unstructured":"Li YJ et al (2020) Hepatic lipids promote liver metastasis. Jci Insight. https:\/\/doi.org\/10.1172\/jci.insight.136215","journal-title":"Jci Insight"},{"key":"10182_CR59","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0150-x","author":"XJ Luo","year":"2018","unstructured":"Luo XJ et al (2018) The implications of signaling lipids in cancer metastasis. Exp Mol Med. https:\/\/doi.org\/10.1038\/s12276-018-0150-x","journal-title":"Exp Mol Med"},{"issue":"3","key":"10182_CR60","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/bcr432","volume":"4","author":"JW Park","year":"2002","unstructured":"Park JW (2002) Liposome-based drug delivery in breast cancer treatment. Breast Cancer Res 4(3):93\u201397","journal-title":"Breast Cancer Res"}],"container-title":["Clinical &amp; Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-022-10182-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10585-022-10182-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-022-10182-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T08:49:33Z","timestamp":1663145373000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10585-022-10182-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,8]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10182"],"URL":"https:\/\/doi.org\/10.1007\/s10585-022-10182-7","relation":{},"ISSN":["0262-0898","1573-7276"],"issn-type":[{"value":"0262-0898","type":"print"},{"value":"1573-7276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,8]]},"assertion":[{"value":"15 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"No potential conflicts of interest were disclosed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}