{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:07:48Z","timestamp":1790698068606,"version":"4.1.0"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA243916"],"award-info":[{"award-number":["R01 CA243916"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA214384"],"award-info":[{"award-number":["R01 CA214384"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 GM13779501"],"award-info":[{"award-number":["R35 GM13779501"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 CA197585"],"award-info":[{"award-number":["R35 CA197585"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32 CA243421"],"award-info":[{"award-number":["F32 CA243421"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5K01 EB028877"],"award-info":[{"award-number":["5K01 EB028877"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31 CA224982"],"award-info":[{"award-number":["F31 CA224982"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dynami Foundation"},{"DOI":"10.13039\/501100008382","name":"A Sister's Hope","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008382","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100002645","name":"Carol M. Baldwin Breast Cancer Research Fund","doi-asserted-by":"publisher","award":["BCRF-18-173"],"award-info":[{"award-number":["BCRF-18-173"]}],"id":[{"id":"10.13039\/100002645","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UM Post-Translational Scholar Program"},{"name":"Advanced Proteome Informatics of Cancer Training Program","award":["T32 CA140044"],"award-info":[{"award-number":["T32 CA140044"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Metastasis"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s10585-022-10185-4","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T16:02:30Z","timestamp":1661356950000},"page":"865-881","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer"],"prefix":"10.1007","volume":"39","author":[{"given":"Sophia M.","family":"Orbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E.","family":"Campit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace G.","family":"Bushnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph T.","family":"Decker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Rebernick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriram","family":"Chandrasekaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max S.","family":"Wicha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline S.","family":"Jeruss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9296-9673","authenticated-orcid":false,"given":"Lonnie D.","family":"Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"issue":"1","key":"10185_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel RL, Miller KD (2020) Jemal A (2020) cancer statistics. CA Cancer J Clin 70(1):7\u201330","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"10185_CR2","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.cell.2006.11.001","volume":"127","author":"GP Gupta","year":"2006","unstructured":"Gupta GP, Massague J (2006) Cancer metastasis: building a framework. Cell 127(4):679\u2013695","journal-title":"Cell"},{"issue":"9","key":"10185_CR3","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1634\/theoncologist.2011-0159","volume":"16","author":"W Irvin Jr","year":"2011","unstructured":"Irvin W Jr, Muss HB, Mayer DK (2011) Symptom management in metastatic breast cancer. Oncologist 16(9):1203\u20131214","journal-title":"Oncologist"},{"key":"10185_CR4","doi-asserted-by":"publisher","first-page":"8094","DOI":"10.1038\/ncomms9094","volume":"6","author":"SM Azarin","year":"2015","unstructured":"Azarin SM et al (2015) In vivo capture and label-free detection of early metastatic cells. Nat Commun 6:8094","journal-title":"Nat Commun"},{"key":"10185_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.acr.2016.07.001","volume":"132","author":"ME Menezes","year":"2016","unstructured":"Menezes ME et al (2016) Detecting tumor metastases: the road to therapy starts here. Adv Cancer Res 132:1\u201344","journal-title":"Adv Cancer Res"},{"issue":"18","key":"10185_CR6","doi-asserted-by":"publisher","first-page":"3786","DOI":"10.1158\/0008-5472.CAN-20-0079","volume":"80","author":"AH Morris","year":"2020","unstructured":"Morris AH et al (2020) Engineered niches to analyze mechanisms of metastasis and guide precision medicine. Cancer Res 80(18):3786\u20133794","journal-title":"Cancer Res"},{"key":"10185_CR7","doi-asserted-by":"publisher","first-page":"120632","DOI":"10.1016\/j.biomaterials.2020.120632","volume":"269","author":"GG Bushnell","year":"2021","unstructured":"Bushnell GG et al (2021) Disease-induced immunomodulation at biomaterial scaffolds detects early pancreatic cancer in a spontaneous model. Biomaterials 269:120632","journal-title":"Biomaterials"},{"key":"10185_CR8","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0140-6736(00)49915-0","volume":"133","author":"S Paget","year":"1889","unstructured":"Paget S (1889) The distribution of secondary growths in cancer of the breast. Lancet 133:571\u2013573","journal-title":"Lancet"},{"issue":"7069","key":"10185_CR9","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/nature04186","volume":"438","author":"RN Kaplan","year":"2005","unstructured":"Kaplan RN et al (2005) VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438(7069):820\u2013827","journal-title":"Nature"},{"key":"10185_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0077","author":"BA Aguado","year":"2017","unstructured":"Aguado BA et al (2017) Engineering the pre-metastatic niche. Nat Biomed Eng. https:\/\/doi.org\/10.1038\/s41551-017-0077","journal-title":"Nat Biomed Eng"},{"issue":"5","key":"10185_CR11","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/nrc.2017.6","volume":"17","author":"H Peinado","year":"2017","unstructured":"Peinado H et al (2017) Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer 17(5):302\u2013317","journal-title":"Nat Rev Cancer"},{"key":"10185_CR12","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.036236","author":"OS Blomberg","year":"2018","unstructured":"Blomberg OS, Spagnuolo L, de Visser KE (2018) Immune regulation of metastasis: mechanistic insights and therapeutic opportunities. Dis Model Mech. https:\/\/doi.org\/10.1242\/dmm.036236","journal-title":"Dis Model Mech"},{"issue":"3\u20134","key":"10185_CR13","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s10555-013-9420-1","volume":"32","author":"J Sceneay","year":"2013","unstructured":"Sceneay J, Smyth MJ, Moller A (2013) The pre-metastatic niche: finding common ground. Cancer Metastasis Rev 32(3\u20134):449\u2013464","journal-title":"Cancer Metastasis Rev"},{"issue":"5","key":"10185_CR14","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.ccell.2016.09.011","volume":"30","author":"Y Liu","year":"2016","unstructured":"Liu Y, Cao X (2016) Characteristics and significance of the pre-metastatic niche. Cancer Cell 30(5):668\u2013681","journal-title":"Cancer Cell"},{"issue":"8","key":"10185_CR15","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s12276-018-0071-8","volume":"50","author":"B Hwang","year":"2018","unstructured":"Hwang B, Lee JH, Bang D (2018) Single-cell RNA sequencing technologies and bioinformatics pipelines. Exp Mol Med 50(8):96","journal-title":"Exp Mol Med"},{"issue":"1","key":"10185_CR16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/nmeth.2769","volume":"11","author":"J Eberwine","year":"2014","unstructured":"Eberwine J et al (2014) The promise of single-cell sequencing. Nat Methods 11(1):25\u201337","journal-title":"Nat Methods"},{"issue":"7341","key":"10185_CR17","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/nature09807","volume":"472","author":"N Navin","year":"2011","unstructured":"Navin N et al (2011) Tumour evolution inferred by single-cell sequencing. Nature 472(7341):90\u201394","journal-title":"Nature"},{"issue":"1","key":"10185_CR18","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1038\/s41467-020-16164-1","volume":"11","author":"N Kim","year":"2020","unstructured":"Kim N et al (2020) Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma. Nat Commun 11(1):2285","journal-title":"Nat Commun"},{"issue":"9","key":"10185_CR19","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/s12276-020-0422-0","volume":"52","author":"J Fan","year":"2020","unstructured":"Fan J, Slowikowski K, Zhang F (2020) Single-cell transcriptomics in cancer: computational challenges and opportunities. Exp Mol Med 52(9):1452\u20131465","journal-title":"Exp Mol Med"},{"issue":"1","key":"10185_CR20","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1002\/bit.27179","volume":"117","author":"GG Bushnell","year":"2020","unstructured":"Bushnell GG et al (2020) Microporous scaffolds loaded with immunomodulatory lentivirus to study the contribution of immune cell populations to tumor cell recruitment in vivo. Biotechnol Bioeng 117(1):210\u2013222","journal-title":"Biotechnol Bioeng"},{"issue":"3","key":"10185_CR21","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1158\/0008-5472.CAN-19-1932","volume":"80","author":"RS Oakes","year":"2020","unstructured":"Oakes RS et al (2020) Metastatic conditioning of myeloid cells at a subcutaneous synthetic niche reflects disease progression and predicts therapeutic outcomes. Cancer Res 80(3):602\u2013612","journal-title":"Cancer Res"},{"issue":"18","key":"10185_CR22","doi-asserted-by":"publisher","first-page":"5209","DOI":"10.1158\/0008-5472.CAN-15-2106","volume":"76","author":"SS Rao","year":"2016","unstructured":"Rao SS et al (2016) Enhanced survival with implantable scaffolds that capture metastatic breast cancer cells in vivo. Cancer Res 76(18):5209\u20135218","journal-title":"Cancer Res"},{"key":"10185_CR23","first-page":"20","volume":"20","author":"BA Pulaski","year":"2001","unstructured":"Pulaski BA, Ostrand-Rosenberg S (2001) Mouse 4T1 breast tumor model. Curr Protoc Immunol 20:20\u201322","journal-title":"Curr Protoc Immunol"},{"issue":"8","key":"10185_CR24","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1158\/0008-5472.CAN-18-2502","volume":"79","author":"GG Bushnell","year":"2019","unstructured":"Bushnell GG et al (2019) Biomaterial scaffolds recruit an aggressive population of metastatic tumor cells in vivo. Cancer Res 79(8):2042\u20132053","journal-title":"Cancer Res"},{"issue":"5","key":"10185_CR25","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.cell.2015.05.002","volume":"161","author":"EZ Macosko","year":"2015","unstructured":"Macosko EZ et al (2015) Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161(5):1202\u20131214","journal-title":"Cell"},{"issue":"12","key":"10185_CR26","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1101\/gr.177881.114","volume":"24","author":"S Picelli","year":"2014","unstructured":"Picelli S et al (2014) Tn5 transposase and tagmentation procedures for massively scaled sequencing projects. Genome Res 24(12):2033\u20132040","journal-title":"Genome Res"},{"issue":"5","key":"10185_CR27","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler A et al (2018) Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol 36(5):411\u2013420","journal-title":"Nat Biotechnol"},{"issue":"7","key":"10185_CR28","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","volume":"177","author":"T Stuart","year":"2019","unstructured":"Stuart T et al (2019) Comprehensive Integration of Single-Cell Data. Cell 177(7):1888-1902.e21","journal-title":"Cell"},{"issue":"8","key":"10185_CR29","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1038\/nprot.2009.97","volume":"4","author":"S Durinck","year":"2009","unstructured":"Durinck S et al (2009) Mapping identifiers for the integration of genomic datasets with the R\/Bioconductor package biomaRt. Nat Protoc 4(8):1184\u20131191","journal-title":"Nat Protoc"},{"issue":"43","key":"10185_CR30","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102(43):15545\u201315550","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10185_CR31","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nbt.2859","volume":"32","author":"C Trapnell","year":"2014","unstructured":"Trapnell C et al (2014) The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Nat Biotechnol 32(4):381\u2013386","journal-title":"Nat Biotechnol"},{"issue":"3","key":"10185_CR32","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.cell.2018.05.061","volume":"174","author":"D van Dijk","year":"2018","unstructured":"van Dijk D et al (2018) Recovering gene interactions from single-cell data using data diffusion. Cell 174(3):716-729.e27","journal-title":"Cell"},{"issue":"52","key":"10185_CR33","doi-asserted-by":"publisher","first-page":"21426","DOI":"10.1073\/pnas.1209673109","volume":"109","author":"S Lipinski","year":"2012","unstructured":"Lipinski S et al (2012) RNAi screening identifies mediators of NOD2 signaling: implications for spatial specificity of MDP recognition. Proc Natl Acad Sci U S A 109(52):21426\u201321431","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10185_CR34","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaz1482","author":"JL Robinson","year":"2020","unstructured":"Robinson JL et al (2020) An atlas of human metabolism. Sci Signal. https:\/\/doi.org\/10.1126\/scisignal.aaz1482","journal-title":"Sci Signal"},{"issue":"3","key":"10185_CR35","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/nbt.1614","volume":"28","author":"JD Orth","year":"2010","unstructured":"Orth JD, Thiele I, Palsson BO (2010) What is flux balance analysis? Nat Biotechnol 28(3):245\u2013248","journal-title":"Nat Biotechnol"},{"issue":"24","key":"10185_CR36","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1093\/bioinformatics\/btq602","volume":"26","author":"H Zur","year":"2010","unstructured":"Zur H, Ruppin E, Shlomi T (2010) iMAT: an integrative metabolic analysis tool. Bioinformatics 26(24):3140\u20133142","journal-title":"Bioinformatics"},{"issue":"41","key":"10185_CR37","doi-asserted-by":"publisher","first-page":"17845","DOI":"10.1073\/pnas.1005139107","volume":"107","author":"S Chandrasekaran","year":"2010","unstructured":"Chandrasekaran S, Price ND (2010) Probabilistic integrative modeling of genome-scale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 107(41):17845\u201317850","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10185_CR38","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/msb.2010.47","volume":"6","author":"NE Lewis","year":"2010","unstructured":"Lewis NE et al (2010) Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale models. Mol Syst Biol 6:390","journal-title":"Mol Syst Biol"},{"issue":"1","key":"10185_CR39","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13059-020-1949-z","volume":"21","author":"CH Holland","year":"2020","unstructured":"Holland CH et al (2020) Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data. Genome Biol 21(1):36","journal-title":"Genome Biol"},{"key":"10185_CR40","first-page":"194431","volume":"6","author":"CH Holland","year":"1863","unstructured":"Holland CH, Szalai B, Saez-Rodriguez J (1863) Transfer of regulatory knowledge from human to mouse for functional genomics analysis. Biochim Biophys Acta Gene Regul Mech 6:194431","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"issue":"8","key":"10185_CR41","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1101\/gr.240663.118","volume":"29","author":"L Garcia-Alonso","year":"2019","unstructured":"Garcia-Alonso L et al (2019) Benchmark and integration of resources for the estimation of human transcription factor activities. Genome Res 29(8):1363\u20131375","journal-title":"Genome Res"},{"issue":"2","key":"10185_CR42","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","volume":"17","author":"R Browaeys","year":"2020","unstructured":"Browaeys R, Saelens W, Saeys Y (2020) NicheNet: modeling intercellular communication by linking ligands to target genes. Nat Methods 17(2):159\u2013162","journal-title":"Nat Methods"},{"issue":"4","key":"10185_CR43","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1038\/s41596-020-0292-x","volume":"15","author":"M Efremova","year":"2020","unstructured":"Efremova M et al (2020) Cell PhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes. Nat Protoc 15(4):1484\u20131506","journal-title":"Nat Protoc"},{"issue":"1","key":"10185_CR44","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s13311-020-00946-y","volume":"18","author":"JY Chen","year":"2021","unstructured":"Chen JY et al (2021) Lentiviral interleukin-10 gene therapy preserves fine motor circuitry and function after a cervical spinal cord injury in male and female mice. Neurotherapeutics 18(1):503\u2013514","journal-title":"Neurotherapeutics"},{"issue":"7556","key":"10185_CR45","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nature14282","volume":"522","author":"SB Coffelt","year":"2015","unstructured":"Coffelt SB et al (2015) IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis. Nature 522(7556):345\u2013348","journal-title":"Nature"},{"issue":"6","key":"10185_CR46","doi-asserted-by":"publisher","first-page":"E566","DOI":"10.1073\/pnas.1424927112","volume":"112","author":"AJ Casbon","year":"2015","unstructured":"Casbon AJ et al (2015) Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils. Proc Natl Acad Sci U S A 112(6):E566\u2013E575","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"10185_CR47","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1080\/15384047.2020.1818518","volume":"21","author":"JT Decker","year":"2020","unstructured":"Decker JT et al (2020) Cyclin E overexpression confers resistance to trastuzumab through noncanonical phosphorylation of SMAD3 in HER2+ breast cancer. Cancer Biol Ther 21(11):994\u20131004","journal-title":"Cancer Biol Ther"},{"issue":"10","key":"10185_CR48","doi-asserted-by":"publisher","first-page":"e1700903","DOI":"10.1002\/adhm.201700903","volume":"7","author":"BA Aguado","year":"2018","unstructured":"Aguado BA et al (2018) Biomaterial scaffolds as pre-metastatic niche mimics systemically alter the primary tumor and tumor microenvironment. Adv Healthc Mater 7(10):e1700903","journal-title":"Adv Healthc Mater"},{"issue":"1","key":"10185_CR49","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s13058-019-1189-x","volume":"21","author":"M Bosiljcic","year":"2019","unstructured":"Bosiljcic M et al (2019) Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs. Breast Cancer Res 21(1):103","journal-title":"Breast Cancer Res"},{"issue":"5","key":"10185_CR50","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646\u2013674","journal-title":"Cell"},{"issue":"1","key":"10185_CR51","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1159\/000330095","volume":"4","author":"G Srikrishna","year":"2012","unstructured":"Srikrishna G (2012) S100A8 and S100A9: new insights into their roles in malignancy. J Innate Immun 4(1):31\u201340","journal-title":"J Innate Immun"},{"issue":"2","key":"10185_CR52","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/s41416-018-0136-4","volume":"119","author":"P Sirnio","year":"2018","unstructured":"Sirnio P et al (2018) High-serum MMP-8 levels are associated with decreased survival and systemic inflammation in colorectal cancer. Br J Cancer 119(2):213\u2013219","journal-title":"Br J Cancer"},{"issue":"4","key":"10185_CR53","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S1535-6108(02)00153-8","volume":"2","author":"S Hiratsuka","year":"2002","unstructured":"Hiratsuka S et al (2002) MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell 2(4):289\u2013300","journal-title":"Cancer Cell"},{"key":"10185_CR54","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201803","author":"F Veglia","year":"2021","unstructured":"Veglia F et al (2021) Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice. J Exp Med. https:\/\/doi.org\/10.1084\/jem.20201803","journal-title":"J Exp Med"},{"issue":"11","key":"10185_CR55","first-page":"2923","volume":"63","author":"F Yi","year":"2003","unstructured":"Yi F, Jaffe R, Prochownik EV (2003) The CCL6 chemokine is differentially regulated by c-Myc and L-Myc, and promotes tumorigenesis and metastasis. Cancer Res 63(11):2923\u20132932","journal-title":"Cancer Res"},{"key":"10185_CR56","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.3389\/fimmu.2019.01197","volume":"10","author":"KJ Baker","year":"2019","unstructured":"Baker KJ, Houston A, Brint E (2019) IL-1 family members in cancer; two sides to every story. Front Immunol 10:1197","journal-title":"Front Immunol"},{"issue":"12","key":"10185_CR57","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.3390\/cancers11122002","volume":"11","author":"KL Owen","year":"2019","unstructured":"Owen KL, Brockwell NK, Parker BS (2019) JAK-STAT signaling: a double-edged sword of immune regulation and cancer progression. Cancers (Basel) 11(12):2002","journal-title":"Cancers (Basel)"},{"issue":"4","key":"10185_CR58","first-page":"345","volume":"27","author":"S Langer","year":"2006","unstructured":"Langer S et al (2006) Jun and Fos family protein expression in human breast cancer: correlation of protein expression and clinicopathological parameters. Eur J Gynaecol Oncol 27(4):345\u2013352","journal-title":"Eur J Gynaecol Oncol"},{"issue":"2","key":"10185_CR59","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/febs.13148","volume":"282","author":"K Beishline","year":"2015","unstructured":"Beishline K, Azizkhan-Clifford J (2015) Sp1 and the \u201challmarks of cancer.\u201d FEBS J 282(2):224\u2013258","journal-title":"FEBS J"},{"issue":"12","key":"10185_CR60","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1002\/ijc.30603","volume":"140","author":"M Fane","year":"2017","unstructured":"Fane M et al (2017) Nuclear factor one transcription factors as epigenetic regulators in cancer. Int J Cancer 140(12):2634\u20132641","journal-title":"Int J Cancer"},{"key":"10185_CR61","doi-asserted-by":"publisher","first-page":"3580719","DOI":"10.1155\/2020\/3580719","volume":"2020","author":"Q Ju","year":"2020","unstructured":"Ju Q et al (2020) NFE2L2 is a potential prognostic biomarker and is correlated with immune infiltration in brain lower grade glioma: a pan-cancer analysis. Oxid Med Cell Longev 2020:3580719","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"10185_CR62","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1161\/ATVBAHA.111.226845","volume":"32","author":"KE Barletta","year":"2012","unstructured":"Barletta KE, Ley K, Mehrad B (2012) Regulation of neutrophil function by adenosine. Arterioscler Thromb Vasc Biol 32(4):856\u2013864","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"10185_CR63","first-page":"617","volume":"8","author":"A Marton","year":"2001","unstructured":"Marton A et al (2001) Anti-inflammatory effects of inosine in human monocytes, neutrophils and epithelial cells in vitro. Int J Mol Med 8(6):617\u2013621","journal-title":"Int J Mol Med"},{"issue":"1","key":"10185_CR64","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nri2470","volume":"9","author":"M Perretti","year":"2009","unstructured":"Perretti M, D\u2019Acquisto F (2009) Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat Rev Immunol 9(1):62\u201370","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"10185_CR65","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.1158\/1055-9965.EPI-08-0439","volume":"17","author":"J Wang","year":"2008","unstructured":"Wang J, John EM, Ingles SA (2008) 5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic acid, and risk for breast cancer. Cancer Epidemiol Biomarkers Prev 17(10):2748\u20132754","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10185_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.09.010","author":"Y Zhang","year":"2021","unstructured":"Zhang Y et al (2021) Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer. Cancer Cell. https:\/\/doi.org\/10.1016\/j.ccell.2021.09.010","journal-title":"Cancer Cell"},{"issue":"9","key":"10185_CR67","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1093\/carcin\/bgi113","volume":"26","author":"KB Bouker","year":"2005","unstructured":"Bouker KB et al (2005) Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis. Carcinogenesis 26(9):1527\u20131535","journal-title":"Carcinogenesis"},{"issue":"5","key":"10185_CR68","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nri.2017.142","volume":"18","author":"K Taniguchi","year":"2018","unstructured":"Taniguchi K, Karin M (2018) NF-kappaB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol 18(5):309\u2013324","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10185_CR69","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1084\/jem.20130062","volume":"212","author":"FC Weber","year":"2015","unstructured":"Weber FC et al (2015) Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity. J Exp Med 212(1):15\u201322","journal-title":"J Exp Med"},{"issue":"1","key":"10185_CR70","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1046\/j.1365-2249.2000.01196.x","volume":"120","author":"L Chen","year":"2000","unstructured":"Chen L, Zhang Z, Sendo F (2000) Neutrophils play a critical role in the pathogenesis of experimental cerebral malaria. Clin Exp Immunol 120(1):125\u2013133","journal-title":"Clin Exp Immunol"},{"issue":"11","key":"10185_CR71","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.trecan.2018.09.001","volume":"4","author":"JP Bottcher","year":"2018","unstructured":"Bottcher JP, Reise Sousa C (2018) The role of type 1 conventional dendritic cells in cancer immunity. Trends Cancer 4(11):784\u2013792","journal-title":"Trends Cancer"},{"issue":"7595","key":"10185_CR72","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nature16985","volume":"531","author":"MB Headley","year":"2016","unstructured":"Headley MB et al (2016) Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature 531(7595):513\u2013517","journal-title":"Nature"},{"key":"10185_CR73","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat1500","author":"S Singhal","year":"2019","unstructured":"Singhal S et al (2019) Human tumor-associated monocytes\/macrophages and their regulation of T cell responses in early-stage lung cancer. Sci Transl Med. https:\/\/doi.org\/10.1126\/scitranslmed.aat1500","journal-title":"Sci Transl Med"},{"issue":"8","key":"10185_CR74","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s00262-017-1976-0","volume":"66","author":"EB Eruslanov","year":"2017","unstructured":"Eruslanov EB (2017) Phenotype and function of tumor-associated neutrophils and their subsets in early-stage human lung cancer. Cancer Immunol Immunother 66(8):997\u20131006","journal-title":"Cancer Immunol Immunother"},{"issue":"11","key":"10185_CR75","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1084\/jem.20151193","volume":"213","author":"R Afik","year":"2016","unstructured":"Afik R et al (2016) Tumor macrophages are pivotal constructors of tumor collagenous matrix. J Exp Med 213(11):2315\u20132331","journal-title":"J Exp Med"},{"issue":"13","key":"10185_CR76","doi-asserted-by":"publisher","first-page":"3662","DOI":"10.1016\/j.celrep.2017.12.011","volume":"21","author":"DH Madsen","year":"2017","unstructured":"Madsen DH et al (2017) Tumor-associated macrophages derived from circulating inflammatory monocytes degrade collagen through cellular uptake. Cell Rep 21(13):3662\u20133671","journal-title":"Cell Rep"},{"issue":"6","key":"10185_CR77","doi-asserted-by":"publisher","first-page":"e1436922","DOI":"10.1080\/2162402X.2018.1436922","volume":"7","author":"T Liu","year":"2018","unstructured":"Liu T et al (2018) Tumor-associated macrophages in human breast cancer produce new monocyte attracting and pro-angiogenic factor YKL-39 indicative for increased metastasis after neoadjuvant chemotherapy. Oncoimmunology 7(6):e1436922","journal-title":"Oncoimmunology"},{"issue":"2","key":"10185_CR78","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/JLB.4RI0818-311R","volume":"106","author":"CE Olingy","year":"2019","unstructured":"Olingy CE, Dinh HQ, Hedrick CC (2019) Monocyte heterogeneity and functions in cancer. J Leukoc Biol 106(2):309\u2013322","journal-title":"J Leukoc Biol"},{"key":"10185_CR79","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194947","author":"M Paolillo","year":"2019","unstructured":"Paolillo M, Schinelli S (2019) Extracellular matrix alterations in metastatic processes. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20194947","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10185_CR80","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10585-008-9209-8","volume":"26","author":"JT Erler","year":"2009","unstructured":"Erler JT, Weaver VM (2009) Three-dimensional context regulation of metastasis. Clin Exp Metastasis 26(1):35\u201349","journal-title":"Clin Exp Metastasis"},{"issue":"9","key":"10185_CR81","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/s41568-020-0281-y","volume":"20","author":"S Jaillon","year":"2020","unstructured":"Jaillon S et al (2020) Neutrophil diversity and plasticity in tumour progression and therapy. Nat Rev Cancer 20(9):485\u2013503","journal-title":"Nat Rev Cancer"},{"issue":"7582","key":"10185_CR82","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/nature16140","volume":"528","author":"SK Wculek","year":"2015","unstructured":"Wculek SK, Malanchi I (2015) Neutrophils support lung colonization of metastasis-initiating breast cancer cells. Nature 528(7582):413\u2013417","journal-title":"Nature"},{"issue":"50","key":"10185_CR83","doi-asserted-by":"publisher","first-page":"21248","DOI":"10.1073\/pnas.1015855107","volume":"107","author":"M Kowanetz","year":"2010","unstructured":"Kowanetz M et al (2010) Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proc Natl Acad Sci U S A 107(50):21248\u201321255","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10185_CR84","doi-asserted-by":"publisher","first-page":"100961","DOI":"10.1016\/j.xpro.2021.100961","volume":"2","author":"C Grosjean","year":"2021","unstructured":"Grosjean C et al (2021) Isolation and enrichment of mouse splenic T cells for ex vivo and in vivo T cell receptor stimulation assays. STAR Protoc 2(4):100961","journal-title":"STAR Protoc"},{"key":"10185_CR85","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1600-065X.1989.tb00543.x","volume":"111","author":"TF Gajewski","year":"1989","unstructured":"Gajewski TF et al (1989) Regulation of T-cell activation: differences among T-cell subsets. Immunol Rev 111:79\u2013110","journal-title":"Immunol Rev"},{"issue":"4","key":"10185_CR86","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.it.2006.02.008","volume":"27","author":"KJ Wood","year":"2006","unstructured":"Wood KJ, Sawitzki B (2006) Interferon gamma: a crucial role in the function of induced regulatory T cells in vivo. Trends Immunol 27(4):183\u2013187","journal-title":"Trends Immunol"},{"issue":"8","key":"10185_CR87","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nri3862","volume":"15","author":"EJ Wherry","year":"2015","unstructured":"Wherry EJ, Kurachi M (2015) Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol 15(8):486\u2013499","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"10185_CR88","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/icb.2012.7","volume":"90","author":"DF Tough","year":"2012","unstructured":"Tough DF (2012) Modulation of T-cell function by type I interferon. Immunol Cell Biol 90(5):492\u2013497","journal-title":"Immunol Cell Biol"},{"issue":"5","key":"10185_CR89","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.4049\/jimmunol.160.5.2059","volume":"160","author":"BT Konieczny","year":"1998","unstructured":"Konieczny BT et al (1998) IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways. J Immunol 160(5):2059\u20132064","journal-title":"J Immunol"},{"issue":"3","key":"10185_CR90","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s10555-006-9000-8","volume":"25","author":"CA Dinarello","year":"2006","unstructured":"Dinarello CA (2006) The paradox of pro-inflammatory cytokines in cancer. Cancer Metastasis Rev 25(3):307\u2013313","journal-title":"Cancer Metastasis Rev"},{"issue":"7","key":"10185_CR91","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1038\/s41591-020-0892-6","volume":"26","author":"BM Allen","year":"2020","unstructured":"Allen BM et al (2020) Systemic dysfunction and plasticity of the immune macroenvironment in cancer models. Nat Med 26(7):1125\u20131134","journal-title":"Nat Med"},{"key":"10185_CR92","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.3389\/fonc.2020.01195","volume":"10","author":"B Schrors","year":"2020","unstructured":"Schrors B et al (2020) Multi-omics characterization of the 4T1 murine mammary gland tumor model. Front Oncol 10:1195","journal-title":"Front Oncol"},{"issue":"2","key":"10185_CR93","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1165\/ajrcmb\/6.2.235","volume":"6","author":"KC Stone","year":"1992","unstructured":"Stone KC et al (1992) Allometric relationships of cell numbers and size in the mammalian lung. Am J Respir Cell Mol Biol 6(2):235\u2013243","journal-title":"Am J Respir Cell Mol Biol"}],"updated-by":[{"DOI":"10.1007\/s10585-023-10215-9","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000}}],"container-title":["Clinical & Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-022-10185-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10585-022-10185-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-022-10185-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T03:08:35Z","timestamp":1686625715000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10585-022-10185-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":93,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10185"],"URL":"https:\/\/doi.org\/10.1007\/s10585-022-10185-4","relation":{},"ISSN":["0262-0898","1573-7276"],"issn-type":[{"value":"0262-0898","type":"print"},{"value":"1573-7276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,24]]},"assertion":[{"value":"24 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2023","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10585-023-10215-9","URL":"https:\/\/doi.org\/10.1007\/s10585-023-10215-9","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}]}}