{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:26:11Z","timestamp":1772119571071,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Zhejiang Provincial Department of Education Research Support Project","award":["Y202249332"],"award-info":[{"award-number":["Y202249332"]}]},{"name":"Zhejiang Provincial Medical and Health Research Project","award":["2023KY475"],"award-info":[{"award-number":["2023KY475"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Metastasis"],"DOI":"10.1007\/s10585-025-10338-1","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T09:51:56Z","timestamp":1743414716000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of combined anti-vascular and two-staged stereotactic radiosurgery therapy for brain metastases with brainstem compression: a retrospective multicenter study"],"prefix":"10.1007","volume":"42","author":[{"given":"Zhu","family":"Xiuming","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Qun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Haining","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Renli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu","family":"Yucun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,29]]},"reference":[{"key":"10338_CR1","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1093\/neuonc\/now127","volume":"18","author":"ND Arvold","year":"2016","unstructured":"Arvold ND, Lee EQ, Mehta MP et al (2016) Updates in the management of brain metastases. Neuro Oncol 18:1043\u20131065","journal-title":"Neuro Oncol"},{"key":"10338_CR2","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1093\/neuros\/nyx522","volume":"83","author":"ST Chao","year":"2018","unstructured":"Chao ST, De Salles A, Hayashi M et al (2018) Stereotactic radiosurgery in the management of limited (1\u20134) brain metasteses: systematic review and international stereotactic radiosurgery society practice guideline. Clin Neurosurg 83:345\u2013353","journal-title":"Clin Neurosurg"},{"key":"10338_CR3","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1016\/j.jocn.2015.05.019","volume":"22","author":"D Ebner","year":"2015","unstructured":"Ebner D, Rava P, Gorovets D et al (2015) Stereotactic radiosurgery for large brain metastases. J Clin Neurosci 22:1650\u20131654","journal-title":"J Clin Neurosci"},{"key":"10338_CR4","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3171\/2018.4.JNS172596","volume":"131","author":"T Serizawa","year":"2019","unstructured":"Serizawa T, Higuchi Y, Yamamoto M et al (2019) Comparison of treatment results between 3- and 2-stage gamma knife radiosurgery for large brain metastases: A retrospective multi-institutional study. J Neurosurg 131:227\u2013237","journal-title":"J Neurosurg"},{"key":"10338_CR5","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s11060-018-03008-8","volume":"140","author":"AE Dohm","year":"2018","unstructured":"Dohm AE, Hughes R, Wheless W et al (2018) Surgical resection and postoperative radiosurgery versus staged radiosurgery for large brain metastases. J Neurooncol 140:749\u2013756","journal-title":"J Neurooncol"},{"key":"10338_CR6","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3171\/2017.3.JNS162532","volume":"129","author":"L Angelov","year":"2018","unstructured":"Angelov L, Mohammadi AM, Bennett EE et al (2018) Impact of 2-staged stereotactic radiosurgery for treatment of brain metastases\u2009\u2265\u20092\u00a0cm. J Neurosurg 129:366\u2013382","journal-title":"J Neurosurg"},{"key":"10338_CR7","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s11060-016-2317-4","volume":"131","author":"T Hasegawa","year":"2017","unstructured":"Hasegawa T, Kato T, Yamamoto T et al (2017) Multisession gamma knife surgery for large brain metastases. J Neurooncol 131:517\u2013524","journal-title":"J Neurooncol"},{"key":"10338_CR8","doi-asserted-by":"crossref","unstructured":"Yomo S, Hayashi M (2014) A minimally invasive treatment option for large metastatic brain tumors: Long-term results of two-session gamma knife stereotactic radiosurgery. Radiat Oncol 9","DOI":"10.1186\/1748-717X-9-132"},{"key":"10338_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s11060-009-0073-4","volume":"96","author":"ME Linskey","year":"2010","unstructured":"Linskey ME, Andrews DW, Asher AL et al (2010) The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline. J Neurooncol 96:45\u201368","journal-title":"J Neurooncol"},{"key":"10338_CR10","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1055\/s-0033-1336173","volume":"74","author":"AH Hawasli","year":"2013","unstructured":"Hawasli AH, Rubin JB, Tran DD et al (2013) Antiangiogenic agents for nonmalignant brain tumors. J Neurol Surg Part B Skull Base 74:136\u2013141","journal-title":"J Neurol Surg Part B Skull Base"},{"key":"10338_CR11","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.3109\/00207454.2015.1092443","volume":"126","author":"MC Alanin","year":"2016","unstructured":"Alanin MC, Klausen C, Caye-Thomasen P et al (2016) Effect of bevacizumab on intracranial meningiomas in patients with neurofibromatosis type 2\u2013 a retrospective case series. Int J Neurosci 126:1002\u20131006","journal-title":"Int J Neurosci"},{"key":"10338_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijerph18052210","volume":"18","author":"E Zamyslowska-Szmytke","year":"2021","unstructured":"Zamyslowska-Szmytke E, Politanski P, Jozefowicz-Korczynska M (2021) Dizziness handicap inventory in clinical evaluation of dizzy patients. Int J Environ Res Public Health 18:1\u201312","journal-title":"Int J Environ Res Public Health"},{"key":"10338_CR13","doi-asserted-by":"crossref","unstructured":"Schiller K, Specht HM, Haller B et al (2017) Correlation between delivered radiation doses to the brainstem or vestibular organ and nausea & vomiting toxicity in patients with head and neck cancers - an observational clinical trial. Radiat Oncol 12","DOI":"10.1186\/s13014-017-0846-4"},{"key":"10338_CR14","doi-asserted-by":"crossref","unstructured":"Hankemeier A, Rollnik JD (2015) The early functional abilities (EFA) scale to assess neurological and neurosurgical early rehabilitation patients. BMC Neurol 15","DOI":"10.1186\/s12883-015-0469-z"},{"key":"10338_CR15","doi-asserted-by":"publisher","first-page":"e270","DOI":"10.1016\/S1470-2045(15)70057-4","volume":"16","author":"NU Lin","year":"2015","unstructured":"Lin NU, Lee EQ, Aoyama H et al (2015) Response assessment criteria for brain metastases: proposal from the RANO group. Lancet Oncol 16:e270\u2013e278","journal-title":"Lancet Oncol"},{"key":"10338_CR16","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1093\/neuros\/nyx355","volume":"83","author":"A Dohm","year":"2018","unstructured":"Dohm A, McTyre ER, Okoukoni C et al (2018) Staged stereotactic radiosurgery for large brain metastases: local control and clinical outcomes of a One-Two punch technique. Clin Neurosurg 83:114\u2013121","journal-title":"Clin Neurosurg"},{"key":"10338_CR17","doi-asserted-by":"publisher","first-page":"e210","DOI":"10.1016\/j.wneu.2022.01.109","volume":"161","author":"EP Damron","year":"2022","unstructured":"Damron EP, Dono A, Chafi H et al (2022) Metastatic neoplasm volume kinetics following 2-Stage stereotactic radiosurgery. World Neurosurg 161:e210\u2013e219","journal-title":"World Neurosurg"},{"key":"10338_CR18","doi-asserted-by":"crossref","unstructured":"Hori Y, Muhsen B, Joshi K, (2020) RADT-01. The efficacy and safety of two-staged stereotactic radiosurgery for large posterior fossa metastases: post-treatment volumetric changes in tumor size, peri-tumoral edema, and fourth ventricle Neuro Oncol 22:ii181\u2013ii181","DOI":"10.1093\/neuonc\/noaa215.756"},{"key":"10338_CR19","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s11060-020-03421-y","volume":"147","author":"D Ito","year":"2020","unstructured":"Ito D, Aoyagi K, Nagano O et al (2020) Comparison of two-stage gamma knife radiosurgery outcomes for large brain metastases among primary cancers. J Neurooncol 147:237\u2013246","journal-title":"J Neurooncol"},{"key":"10338_CR20","first-page":"1666","volume":"137","author":"A Cho","year":"2022","unstructured":"Cho A, Medvedeva K, Kranawetter B, Untersteiner H, Hirschmann D, Lepilina O, Baulin A, Buschmann M, Ertl A, Marik W, Dorfer C, R\u00f6ssler K, Gatterbauer B, Ilyalov SFJ (2022) How to dose-stage large or high-risk brain metastases: an alternative two-fraction radiosurgical treatment approach. J Neuro Surg 137:1666\u20131675","journal-title":"J Neuro Surg"},{"key":"10338_CR21","doi-asserted-by":"publisher","unstructured":"Tsien CI, Pugh SL, Dicker AP et al (2023) NRG Oncology\/RTOG1205: A Randomized Phase II Trial of Concurrent Bevacizumab and Reirradiation Versus Bevacizumab Alone as Treatment for Recurrent Glioblastoma. J Clin Oncol. 41(6):1285\u20131295. https:\/\/doi.org\/10.1200\/JCO.22.00164. Epub 2022 Oct 19","DOI":"10.1200\/JCO.22.00164"},{"key":"10338_CR22","doi-asserted-by":"publisher","first-page":"273","DOI":"10.14740\/jocmr2936e","volume":"9","author":"D Delishaj","year":"2017","unstructured":"Delishaj D, Ursino S, Pasqualetti F et al (2017) Bevacizumab for the treatment of Radiation-Induced cerebral necrosis: A systematic review of the literature. J Clin Med Res 9:273\u2013280","journal-title":"J Clin Med Res"},{"key":"10338_CR23","doi-asserted-by":"publisher","first-page":"e210","DOI":"10.1016\/j.wneu.2020.08.081","volume":"144","author":"OP Erpolat","year":"2020","unstructured":"Erpolat OP, Demircan NV, Sar\u0131bas GS et al (2020) A comparison of Ramipril and bevacizumab to mitigate Radiation-Induced brain necrosis: an experimental study. World Neurosurg 144:e210\u2013e220","journal-title":"World Neurosurg"},{"key":"10338_CR24","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s11060-013-1233-0","volume":"115","author":"D Lubelski","year":"2013","unstructured":"Lubelski D, Abdullah KG, Weil RJ, Marko NF (2013) Bevacizumab for radiation necrosis following treatment of high grade glioma: A systematic review of the literature. J Neurooncol 115:317\u2013322","journal-title":"J Neurooncol"},{"key":"10338_CR25","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.21037\/apm-20-2417","volume":"10","author":"J Li","year":"2021","unstructured":"Li J, He J, Cai L, Lai M, Hu Q, Ren C, Wen L, Wang J, Zhou J, Zhou Z, Li S, Ye M, Shan C, Longhua Chen CZ (2021) Bevacizumab as a treatment for radiation necrosis following stereotactic radio surgery for brain metastases clinical and radiation dosimetric impacts. Ann Palliat Med 10:2018\u20132026","journal-title":"Ann Palliat Med"},{"key":"10338_CR26","doi-asserted-by":"crossref","unstructured":"Kraft J, van Timmeren JE, Frei S, Mayinger M, Borsky K, Kirchner C, Stark LS, Tanadini-Lang S, Wolpert F, Weller M, Woodruff HC, Guckenberger MAN (2022) Comprehensive summary and retrospective evaluation of prognostic scores for patients with newly diagnosed brain metastases treated with upfront radiosurgery in a modern patient collective. Radiother Oncol 23\u201331","DOI":"10.1016\/j.radonc.2022.04.024"},{"key":"10338_CR27","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s10014-017-0284-x","volume":"34","author":"R Tamura","year":"2017","unstructured":"Tamura R, Tanaka T, Miyake K et al (2017) Bevacizumab for malignant gliomas: current indications, mechanisms of action and resistance, and markers of response. Brain Tumor Pathol 34:62\u201377. https:\/\/doi.org\/10.1007\/s10014-017-0284-x","journal-title":"Brain Tumor Pathol"},{"key":"10338_CR28","doi-asserted-by":"publisher","unstructured":"Wang Z, Chen H, Chen Q et al (203) \u2018Sandwich treatment\u2019 for posterior fossa brain metastases with volume larger than 4cm3: a multicentric retrospective study. Clin Exp Metastasis. 40(5):415\u2013422. https:\/\/doi.org\/10.1007\/s10585-023-10220-y","DOI":"10.1007\/s10585-023-10220-y"},{"key":"10338_CR29","first-page":"105","volume":"7","author":"EE Ginalis","year":"2020","unstructured":"Ginalis EE, Cui T, Weiner J et al (2020) Two-staged stereotactic radiosurgery for the treatment of large brain metastases: single institution experience and review of literature. J Radiosurgery SBRT 7:105\u2013114","journal-title":"J Radiosurgery SBRT"}],"container-title":["Clinical & Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-025-10338-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10585-025-10338-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-025-10338-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T06:09:24Z","timestamp":1749535764000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10585-025-10338-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,29]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["10338"],"URL":"https:\/\/doi.org\/10.1007\/s10585-025-10338-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4467801\/v1","asserted-by":"object"}]},"ISSN":["1573-7276"],"issn-type":[{"value":"1573-7276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,29]]},"assertion":[{"value":"23 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present study was approved by the Institutional Ethics Committee of Zhejiang Provincial People\u2019s Hospital ( 2022 No. 066).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21"}}