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All procedures performed in studies involving human participants were in accordance with the standards upheld by the Ethics Committee of First Hospital of Quanzhou Affiliated to Fujian Medical University and with those of the 1964 Helsinki Declaration and its later amendments for ethical research involving human subjects (Approval No.2023072). All animal experiments were approved by the Ethics Committee of First Hospital of Quanzhou Affiliated to Fujian Medical University (Approval No.2023072) for the use of animals and conducted in accordance with the National Institutes of Health Laboratory Animal Care and Use Guidelines. The animal experiment complies with the ARRIVE guidelines and in accordance with the National Institutes of Health guide for the care and use of Laboratory animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from a legally authorized representative(s) for anonymized patient information to be published in this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"22"}}