{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T10:09:19Z","timestamp":1784023759262,"version":"3.55.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project","award":["2023ZL189"],"award-info":[{"award-number":["2023ZL189"]}]},{"name":"Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project","award":["2023ZL189"],"award-info":[{"award-number":["2023ZL189"]}]},{"name":"Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project","award":["2023ZL189"],"award-info":[{"award-number":["2023ZL189"]}]},{"name":"Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project","award":["2023ZL189"],"award-info":[{"award-number":["2023ZL189"]}]},{"name":"Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project","award":["2023ZL189"],"award-info":[{"award-number":["2023ZL189"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Metastasis"],"DOI":"10.1007\/s10585-026-10418-w","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:09:55Z","timestamp":1784020195000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Luteolin inhibits hyperglycemia-induced epithelial\u2013mesenchymal transition and malignant progression in gastric cancer via targeting AKR1B1-mediated glucose metabolism"],"prefix":"10.1007","volume":"43","author":[{"given":"Qin","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feibao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuxing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"10418_CR1","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1007\/s00432-021-03861-7","volume":"148","author":"C Roderburg","year":"2022","unstructured":"Roderburg C, Loosen SH, Hoyer L, Luedde T, Kostev K (2022) Prevalence of diabetes mellitus among 80,193 gastrointestinal cancer patients in five European and three Asian countries. J Cancer Res Clin Oncol 148:1057\u20131062","journal-title":"J Cancer Res Clin Oncol"},{"key":"10418_CR2","doi-asserted-by":"publisher","first-page":"e13561","DOI":"10.1111\/1753-0407.13561","volume":"16","author":"K De la Torre","year":"2024","unstructured":"De la Torre K, Song M, Abe SK, Rahman MS, Islam MR, Saito E et al (2024) Diabetes and gastric cancer incidence and mortality in the Asia Cohort Consortium: a pooled analysis of more than a half million participants. J diabetes 16:e13561","journal-title":"J diabetes"},{"key":"10418_CR3","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1186\/s12885-024-13232-3","volume":"24","author":"Z Yu","year":"2024","unstructured":"Yu Z, Liang C, Li R, Xu Q, Gao J, Li P et al (2024) The impact of diabetes mellitus on short and long term outcomes in patients with gastric cancer following radical surgery: a retrospective cohort study with propensity score matching. BMC Cancer 24:1461","journal-title":"BMC Cancer"},{"key":"10418_CR4","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1186\/s12935-019-1075-8","volume":"19","author":"X Xu","year":"2019","unstructured":"Xu X, Chen B, Zhu S, Zhang J, He X, Cao G et al (2019) Hyperglycemia promotes Snail-induced epithelial\u2013mesenchymal transition of gastric cancer via activating ENO1 expression. Cancer Cell Int 19:344","journal-title":"Cancer Cell Int"},{"key":"10418_CR5","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1111\/cas.15692","volume":"114","author":"MQ Wang","year":"2023","unstructured":"Wang MQ, Chen YR, Xu HW, Zhan JR, Suo DQ, Wang JJ et al (2023) HKDC1 upregulation promotes glycolysis and disease progression, and confers chemoresistance onto gastric cancer. Cancer Sci 114:1365\u20131377","journal-title":"Cancer Sci"},{"key":"10418_CR6","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1001\/jamaoncol.2018.6619","volume":"5","author":"D Hu","year":"2019","unstructured":"Hu D, Peng F, Niu W (2019) Risk of diabetes associated with cancer development. JAMA Oncol 5:429","journal-title":"JAMA Oncol"},{"key":"10418_CR7","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/s41420-022-01030-4","volume":"8","author":"J Yu","year":"2022","unstructured":"Yu J, Hu D, Wang L, Fan Z, Xu C, Lin Y et al (2022) Hyperglycemia induces gastric carcinoma proliferation and migration via the Pin1\/BRD4 pathway. Cell death discovery 8:224","journal-title":"Cell death discovery"},{"key":"10418_CR8","doi-asserted-by":"publisher","first-page":"2902","DOI":"10.1080\/21655979.2022.2026730","volume":"13","author":"X He","year":"2022","unstructured":"He X, Cheng X, Ding J, Xiong M, Chen B, Cao G (2022) Hyperglycemia induces miR-26-5p down-regulation to overexpress PFKFB3 and accelerate epithelial-mesenchymal transition in gastric cancer. Bioengineered 13:2902\u20132917","journal-title":"Bioengineered"},{"key":"10418_CR9","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1159\/000480314","volume":"43","author":"J Yu","year":"2017","unstructured":"Yu J, Li J, Chen Y, Cao W, Lu Y, Yang J et al (2017) Snail enhances glycolysis in the epithelial-mesenchymal transition process by targeting FBP1 in gastric cancer. Cell Physiol Biochem Int J experimental Cell Physiol Biochem Pharmacol 43:31\u201338","journal-title":"Cell Physiol biochemistry: Int J experimental Cell Physiol Biochem Pharmacol"},{"key":"10418_CR10","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","volume":"20","author":"A Dongre","year":"2019","unstructured":"Dongre A, Weinberg RA (2019) New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol 20:69\u201384","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10418_CR11","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.3748\/wjg.v23.i23.4233","volume":"23","author":"S Zhuang","year":"2017","unstructured":"Zhuang S, Jian YM, Sun YN (2017) Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db\/db mice. World J Gastroenterol 23:4233\u20134242","journal-title":"World J Gastroenterol"},{"key":"10418_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4161\/15384047.2014.987021","volume":"16","author":"G Han","year":"2015","unstructured":"Han G, Gong H, Wang Y, Guo S, Liu K (2015) AMPK\/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell. Cancer Biol Ther 16:77\u201387","journal-title":"Cancer Biol Ther"},{"key":"10418_CR13","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/s41401-021-00702-8","volume":"43","author":"JJ Kou","year":"2022","unstructured":"Kou JJ, Shi JZ, He YY, Hao JJ, Zhang HY, Luo DM et al (2022) Luteolin alleviates cognitive impairment in Alzheimer\u2019s disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation. Acta Pharmacol Sin 43:840\u2013849","journal-title":"Acta Pharmacol Sin"},{"key":"10418_CR14","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1002\/biof.1706","volume":"47","author":"YH Siddique","year":"2021","unstructured":"Siddique YH (2021) Role of luteolin in overcoming Parkinson\u2019s disease. Biofactors 47:198\u2013206","journal-title":"Biofactors"},{"key":"10418_CR15","doi-asserted-by":"publisher","first-page":"102848","DOI":"10.1016\/j.redox.2023.102848","volume":"66","author":"Z He","year":"2023","unstructured":"He Z, Li X, Wang Z, Cao Y, Han S, Li N et al (2023) Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor \u03b3-dependent mechanism in Alzheimer\u2019s disease. Redox Biol 66:102848","journal-title":"Redox Biol"},{"key":"10418_CR16","doi-asserted-by":"publisher","first-page":"1217165","DOI":"10.3389\/fendo.2023.1217165","volume":"14","author":"DK Sahoo","year":"2023","unstructured":"Sahoo DK, Heilmann RM, Paital B, Patel A, Yadav VK, Wong D et al (2023) Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease. Front Endocrinol 14:1217165","journal-title":"Front Endocrinol"},{"key":"10418_CR17","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.1002\/ptr.8217","volume":"38","author":"M Zhu","year":"2024","unstructured":"Zhu M, Sun Y, Su Y, Guan W, Wang Y, Han J et al (2024) Luteolin: A promising multifunctional natural flavonoid for human diseases. Phytother Res 38:3417\u20133443","journal-title":"Phytother Res"},{"issue":"3","key":"10418_CR18","doi-asserted-by":"publisher","first-page":"554","DOI":"10.3390\/vaccines11030554","volume":"11","author":"M \u00c7etinkaya","year":"2023","unstructured":"\u00c7etinkaya M, Baran Y (2023) Therapeutic potential of luteolin on cancer. Vaccines 11(3):554","journal-title":"Vaccines"},{"key":"10418_CR19","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.freeradbiomed.2023.09.014","volume":"208","author":"Y Zheng","year":"2023","unstructured":"Zheng Y, Li L, Chen H, Zheng Y, Tan X, Zhang G et al (2023) Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression. Free Radic Biol Med 208:530\u2013544","journal-title":"Free Radic Biol Med"},{"key":"10418_CR20","doi-asserted-by":"publisher","first-page":"5315","DOI":"10.1002\/ptr.7963","volume":"37","author":"X Hao","year":"2023","unstructured":"Hao X, Zu M, Ning J, Zhou X, Gong Y, Han X et al (2023) Antitumor effect of luteolin proven by patient-derived organoids of gastric cancer. Phytother Res 37:5315\u20135327","journal-title":"Phytother Res"},{"issue":"6","key":"10418_CR21","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.3390\/nu14061155","volume":"14","author":"S Caporali","year":"2022","unstructured":"Caporali S, De Stefano A, Calabrese C, Giovannelli A, Pieri M, Savini I et al (2022) Anti-inflammatory and active biological properties of the plant-derived bioactive compounds luteolin and luteolin 7-glucoside. Nutrients 14(6):1155","journal-title":"Nutrients"},{"key":"10418_CR22","doi-asserted-by":"publisher","first-page":"176271","DOI":"10.1016\/j.ejphar.2023.176271","volume":"963","author":"W Li","year":"2024","unstructured":"Li W, Wang X, Chen Y, Ding Y, Ling X, Yuan B et al (2024) Luteolin-7-O-glucoside promotes macrophage release of IFN-\u03b2 by maintaining mitochondrial function and corrects the disorder of glucose metabolism during RSV infection. Eur J Pharmacol 963:176271","journal-title":"Eur J Pharmacol"},{"key":"10418_CR23","doi-asserted-by":"publisher","first-page":"eabg6428","DOI":"10.1126\/scitranslmed.abg6428","volume":"13","author":"KR Zhang","year":"2021","unstructured":"Zhang KR, Zhang YF, Lei HM, Tang YB, Ma CS, Lv QM et al (2021) Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer. Sci Transl Med 13:eabg6428","journal-title":"Sci Transl Med"},{"key":"10418_CR24","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/s12276-023-01153-3","volume":"56","author":"YL Kang","year":"2024","unstructured":"Kang YL, Kim J, Kwak SB, Kim YS, Huh J, Park JW (2024) The polyol pathway and nuclear ketohexokinase A signaling drive hyperglycemia-induced metastasis of gastric cancer. Exp Mol Med 56:220\u2013234","journal-title":"Exp Mol Med"},{"key":"10418_CR25","doi-asserted-by":"publisher","first-page":"9661","DOI":"10.18632\/aging.205041","volume":"15","author":"L Liu","year":"2023","unstructured":"Liu L, Zhu L, Cheng Z, Sun Y, Zhou Y, Cao J (2023) Aberrant expression of AKR1B1 indicates poor prognosis and promotes gastric cancer progression by regulating the AKT-mTOR pathway. Aging 15:9661\u20139675","journal-title":"Aging"},{"key":"10418_CR26","doi-asserted-by":"publisher","first-page":"100974","DOI":"10.1016\/j.jhepr.2023.100974","volume":"6","author":"NP Syamprasad","year":"2024","unstructured":"Syamprasad NP, Jain S, Rajdev B, Panda SR, Kumar GJ, Shaik KM et al (2024) AKR1B1 drives hyperglycemia-induced metabolic reprogramming in MASLD-associated hepatocellular carcinoma. JHEP reports: Innov Hepatol 6:100974","journal-title":"JHEP reports: Innov Hepatol"},{"key":"10418_CR27","doi-asserted-by":"publisher","first-page":"4411","DOI":"10.7150\/ijbs.81972","volume":"19","author":"Z Ma","year":"2023","unstructured":"Ma Z, Sun Q, Zhang C, Zheng Q, Liu Y, Xu H et al (2023) RHOJ Induces Epithelial-to-Mesenchymal Transition by IL-6\/STAT3 to Promote Invasion and Metastasis in Gastric Cancer. Int J Biol Sci 19:4411\u20134426","journal-title":"Int J Biol Sci"},{"key":"10418_CR28","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1016\/j.cell.2018.03.065","volume":"173","author":"L Dai","year":"2018","unstructured":"Dai L, Zhao T, Bisteau X, Sun W, Prabhu N, Lim YT et al (2018) Modulation of Protein-Interaction States through the Cell Cycle. Cell 173:1481\u20131494e13","journal-title":"Cell"},{"key":"10418_CR29","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1080\/15548627.2024.2439657","volume":"21","author":"B Hao","year":"2025","unstructured":"Hao B, Lin S, Liu H, Xu J, Chen L, Zheng T et al (2025) Baicalein tethers CD274\/PD-L1 for autophagic degradation to boost antitumor immunity. Autophagy 21:917\u2013933","journal-title":"Autophagy"},{"key":"10418_CR30","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s12943-020-01253-y","volume":"19","author":"J Lou","year":"2020","unstructured":"Lou J, Hao Y, Lin K, Lyu Y, Chen M, Wang H et al (2020) Circular RNA CDR1as disrupts the p53\/MDM2 complex to inhibit Gliomagenesis. Mol Cancer 19:138","journal-title":"Mol Cancer"},{"key":"10418_CR31","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1002\/kjm2.12624","volume":"39","author":"Y Cheng","year":"2023","unstructured":"Cheng Y, Ni YJ, Tang LM (2023) ZNF521\/EBF1 axis regulates AKR1B1 to promote the proliferation, migration, and invasion of gastric cancer cells. Kaohsiung J Med Sci 39:244\u2013253","journal-title":"Kaohsiung J Med Sci"},{"key":"10418_CR32","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s13020-023-00820-x","volume":"18","author":"F Wang","year":"2023","unstructured":"Wang F, Sun Z, Zhang Q, Yang H, Yang G, Yang Q et al (2023) Curdione induces ferroptosis mediated by m6A methylation via METTL14 and YTHDF2 in colorectal cancer. Chin Med 18:122","journal-title":"Chin Med"},{"key":"10418_CR33","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.7150\/ijbs.89942","volume":"20","author":"F Fontana","year":"2024","unstructured":"Fontana F, Giannitti G, Marchesi S, Limonta P (2024) The PI3K\/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer. Int J Biol Sci 20:3113\u20133125","journal-title":"Int J Biol Sci"},{"key":"10418_CR34","doi-asserted-by":"publisher","first-page":"591239","DOI":"10.3389\/fcell.2020.591239","volume":"8","author":"E Xu","year":"2020","unstructured":"Xu E, Xia X, Jiang C, Li Z, Yang Z, Zheng C et al (2020) GPER1 Silencing suppresses the proliferation, migration, and invasion of gastric cancer cells by inhibiting PI3K\/AKT-mediated EMT. Front cell Dev biology 8:591239","journal-title":"Front cell Dev biology"},{"issue":"11","key":"10418_CR35","doi-asserted-by":"publisher","first-page":"5955","DOI":"10.3390\/ijms22115955","volume":"22","author":"NR Lee","year":"2021","unstructured":"Lee NR, Kim DY, Jin H, Meng R, Chae OH, Kim SH et al (2021) Inactivation of the Akt\/FOXM1 signaling pathway by panobinostat suppresses the proliferation and metastasis of gastric cancer cells. Int J Mol Sci 22(11):5955","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10418_CR36","doi-asserted-by":"publisher","first-page":"4012","DOI":"10.3390\/ijms21114012","volume":"21","author":"J Machlowska","year":"2020","unstructured":"Machlowska J, Baj J, Sitarz M, Maciejewski R, Sitarz R (2020) Gastric cancer: epidemiology, risk factors, classification, genomic characteristics and treatment strategies. Int J Mol Sci 21(11):4012","journal-title":"Int J Mol Sci"},{"key":"10418_CR37","doi-asserted-by":"publisher","first-page":"111598","DOI":"10.1016\/j.mce.2022.111598","volume":"547","author":"R Lai","year":"2022","unstructured":"Lai R, Ji L, Zhang X, Xu Y, Zhong Y, Chen L et al (2022) Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions. Mol Cell Endocrinol 547:111598","journal-title":"Mol Cell Endocrinol"},{"key":"10418_CR38","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1038\/s41418-024-01393-4","volume":"31","author":"Q Zhao","year":"2024","unstructured":"Zhao Q, Han B, Wang L, Wu J, Wang S, Ren Z et al (2024) AKR1B1-dependent fructose metabolism enhances malignancy of cancer cells. Cell Death Differ 31:1611\u20131624","journal-title":"Cell Death Differ"},{"issue":"13","key":"10418_CR39","doi-asserted-by":"publisher","first-page":"398","DOI":"10.3390\/molecules27133981","volume":"27","author":"A Saeed","year":"2022","unstructured":"Saeed A, Ejaz SA, Sarfraz M, Tamam N, Siddique F, Riaz N et al (2022) Discovery of Phenylcarbamoylazinane-1,2,4-triazole amides derivatives as the potential inhibitors of Aldo-Keto reductases (AKR1B1 & AKRB10): potential lead molecules for treatment of colon cancer. Molecules 27(13):398","journal-title":"Molecules"},{"key":"10418_CR40","doi-asserted-by":"publisher","first-page":"153437","DOI":"10.1016\/j.phymed.2020.153437","volume":"81","author":"HT Wu","year":"2021","unstructured":"Wu HT, Lin J, Liu YE, Chen HF, Hsu KW, Lin SH et al (2021) Luteolin suppresses androgen receptor-positive triple-negative breast cancer cell proliferation and metastasis by epigenetic regulation of MMP9 expression via the AKT\/mTOR signaling pathway. Phytomedicine: Int J phytotherapy phytopharmacology 81:153437","journal-title":"Phytomedicine: Int J phytotherapy phytopharmacology"},{"key":"10418_CR41","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.62347\/HYNZ9211","volume":"14","author":"Y Mai","year":"2024","unstructured":"Mai Y, Liao C, Wang S, Zhou X, Meng L, Chen C et al (2024) High glucose-induced NCAPD2 upregulation promotes malignant phenotypes and regulates EMT via the Wnt\/\u03b2-catenin signaling pathway in HCC. Am J cancer Res 14:1685\u20131711","journal-title":"Am J cancer Res"},{"key":"10418_CR42","doi-asserted-by":"publisher","first-page":"12398","DOI":"10.1038\/s41598-025-96666-4","volume":"15","author":"G Shi","year":"2025","unstructured":"Shi G, Wei J, Rahemu S, Zhou J, Li X (2025) Study on the regulatory mechanism of luteolin inhibiting WDR72 on the proliferation and metastasis of non small cell lung cancer. Sci Rep 15:12398","journal-title":"Sci Rep"},{"key":"10418_CR43","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/ptr.8066","volume":"38","author":"M Shi","year":"2024","unstructured":"Shi M, Chen Z, Gong H, Peng Z, Sun Q, Luo K et al (2024) Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches. Phytother Res 38:880\u2013911","journal-title":"Phytother Res"}],"container-title":["Clinical & Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-026-10418-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10585-026-10418-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-026-10418-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T10:02:01Z","timestamp":1784023321000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10585-026-10418-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["10418"],"URL":"https:\/\/doi.org\/10.1007\/s10585-026-10418-w","relation":{},"ISSN":["1573-7276"],"issn-type":[{"value":"1573-7276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]},"assertion":[{"value":"23 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Experimental Animal Welfare and Ethics Committee of Affiliated Jinhua Hospital, Zhejiang University School of Medicine (Approval NO.: AL-JHYY2025170).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"35"}}