{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:37:07Z","timestamp":1791981427060,"version":"4.4.0"},"reference-count":340,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Metastasis"],"DOI":"10.1007\/s10585-026-10424-y","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T08:02:43Z","timestamp":1787126563000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Platelet-derived mitochondrial transfer in cancer metastasis: mechanisms, functional consequences, and translational opportunities"],"prefix":"10.1007","volume":"43","author":[{"given":"Farshad","family":"Heydari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheila","family":"Fahmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-8037","authenticated-orcid":false,"given":"Sameer","family":"Alqassimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasrin","family":"Mansuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8112-7633","authenticated-orcid":false,"given":"Rithab Ibrahim","family":"Al-Samawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Mozaffari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Hamblin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalal","family":"Naghinezhad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"issue":"1","key":"10424_CR1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41392-024-01955-5","volume":"9","author":"Z Liu","year":"2024","unstructured":"Liu Z et al (2024) Multi-stage mechanisms of tumor metastasis and therapeutic strategies. Signal Transduct Target Ther 9(1):270","journal-title":"Signal Transduct Target Ther"},{"issue":"12","key":"10424_CR2","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/s41568-024-00752-0","volume":"24","author":"N Rabas","year":"2024","unstructured":"Rabas N et al (2024) Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells. Nat Rev Cancer 24(12):829\u2013849","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"10424_CR3","doi-asserted-by":"publisher","first-page":"e350","DOI":"10.1002\/mco2.350","volume":"4","author":"K Liao","year":"2023","unstructured":"Liao K et al (2023) The role of platelets in the regulation of tumor growth and metastasis: the mechanisms and targeted therapy. MedComm (2020) 4(5):e350","journal-title":"MedComm (2020)"},{"issue":"5","key":"10424_CR4","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.ccr.2011.09.009","volume":"20","author":"M Labelle","year":"2011","unstructured":"Labelle M, Begum S, Hynes RO (2011) Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 20(5):576\u2013590","journal-title":"Cancer Cell"},{"issue":"1","key":"10424_CR5","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1038\/s41467-024-47516-w","volume":"15","author":"MJ Garcia-Leon","year":"2024","unstructured":"Garcia-Leon MJ et al (2024) Platelets favor the outgrowth of established metastases. Nat Commun 15(1):3297","journal-title":"Nat Commun"},{"key":"10424_CR6","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2026.10043","author":"M Morales-Pacheco","year":"2026","unstructured":"Naghinezhad J, Kamali Yazdi E, Mohajerian A, Yousefi Chermehini N, Ghanavati P, Motamedi H, Rezaeeyan H. The Tumor-Platelet-Immune Interface: Driving Metastasis, Pre-Metastatic Niche Formation and Therapeutic Vulnerabilities. Expert Rev Mol Med. 2026 Apr 7;28:e23. 10.1017\/erm.2026.10043. PMID: 41943941; PMCID: PMC13255538 https:\/\/doi.org\/10.1017\/erm.2026.10043","journal-title":"Expert Rev Mol Med"},{"key":"10424_CR7","doi-asserted-by":"crossref","unstructured":"Zhang L et al (2026) Platelet\u2013circulating tumor cell crosstalk: a pivotal target in cancer diagnosis and therapy (Review). Oncol Rep, 55(1)","DOI":"10.3892\/or.2025.9007"},{"key":"10424_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s12645-026-00375-0","author":"Farshad Heydari","year":"2026","unstructured":"Heydari, F., Chermehini, N.Y., Safari, Z. et al. Targeting glycoprotein VI (GPVI) in cancer: mechanistic insights and therapeutic strategies to suppress metastasis and thrombosis. Cancer Nano 17, 30 (2026). https:\/\/doi.org\/10.1186\/s12645-026-00375-0 https:\/\/doi.org\/10.1186\/s12645-026-00375-0","journal-title":"Cancer Nanotechnology"},{"key":"10424_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2026.06.032","author":"Fateme Farhid","year":"2026","unstructured":"Farhid F, Heydari F, Hamblin MR, Masoudifar S, Sahebkar A, Naghinezhad J. Intercellular Mitochondrial Transfer and Mitochondrial Transplantation in Cardiovascular Disease. Can J Cardiol. 2026 Jul 7:S0828-282X(26)00654-9. doi: 10.1016\/j.cjca.2026.06.032. Epub ahead of print. PMID: 42413818 https:\/\/doi.org\/10.1016\/j.cjca.2026.06.032","journal-title":"Can J Cardiol"},{"issue":"1","key":"10424_CR10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s42255-024-01200-x","volume":"7","author":"JR Brestoff","year":"2025","unstructured":"Brestoff JR et al (2025) Recommendations for mitochondria transfer and transplantation nomenclature and characterization. Nat Metab 7(1):53\u201367","journal-title":"Nat Metab"},{"issue":"9","key":"10424_CR11","doi-asserted-by":"publisher","first-page":"e12951","DOI":"10.1111\/tra.12951","volume":"25","author":"H Liu","year":"2024","unstructured":"Liu H et al (2024) Intercellular mitochondrial transfer: the novel therapeutic mechanism for diseases. Traffic 25(9):e12951","journal-title":"Traffic"},{"issue":"8049","key":"10424_CR12","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41586-024-08439-0","volume":"638","author":"H Ikeda","year":"2025","unstructured":"Ikeda H et al (2025) Immune evasion through mitochondrial transfer in the tumour microenvironment. Nature 638(8049):225\u2013236","journal-title":"Nature"},{"issue":"9","key":"10424_CR13","doi-asserted-by":"publisher","first-page":"113147","DOI":"10.1016\/j.celrep.2023.113147","volume":"42","author":"W Zhang","year":"2023","unstructured":"Zhang W et al (2023) Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria. Cell Rep 42(9):113147","journal-title":"Cell Rep"},{"key":"10424_CR14","doi-asserted-by":"publisher","first-page":"1324158","DOI":"10.3389\/fcell.2023.1324158","volume":"11","author":"L Cereceda","year":"2023","unstructured":"Cereceda L et al (2023) Impact of platelet-derived mitochondria transfer in the metabolic profiling and progression of metastatic MDA-MB-231 human triple-negative breast cancer cells. Front Cell Dev Biol 11:1324158","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"10424_CR15","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1158\/1541-7786.MCR-23-0329","volume":"22","author":"V Veilleux","year":"2024","unstructured":"Veilleux V et al (2024) Mitochondria transfer by platelet-derived microparticles regulates breast cancer bioenergetic states and malignant features. Mol Cancer Res 22(3):268\u2013281","journal-title":"Mol Cancer Res"},{"key":"10424_CR16","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3389\/fcell.2016.00107","volume":"4","author":"D Torralba","year":"2016","unstructured":"Torralba D, Baixauli F, S\u00e1nchez-Madrid F (2016) Mitochondria know no boundaries: mechanisms and functions of intercellular mitochondrial transfer. Front Cell Dev Biol 4:107","journal-title":"Front Cell Dev Biol"},{"key":"10424_CR17","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.3389\/fonc.2020.01350","volume":"10","author":"S Lucotti","year":"2020","unstructured":"Lucotti S, Muschel RJ (2020) Platelets and metastasis: new implications of an old interplay. Front Oncol 10:1350","journal-title":"Front Oncol"},{"key":"10424_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-026-00957-5","author":"Heydari Farshad","year":"2026","unstructured":"Heydari, F., Zendehdel, H., Varkiani, M.M. et al. Guided immunotherapy for residual solid tumor: integrating platelets and CAR T cells to reduce post-surgical recurrence. Biomark Res (2026). https:\/\/doi.org\/10.1186\/s40364-026-00957-5 https:\/\/doi.org\/10.1186\/s40364-026-00957-5","journal-title":"Biomarker Res"},{"issue":"6","key":"10424_CR19","first-page":"541","volume":"74","author":"M Zucchella","year":"1989","unstructured":"Zucchella M et al (1989) Human tumor cells cultured in vitro activate platelet function by producing ADP or thrombin. Haematologica 74(6):541\u2013545","journal-title":"Haematologica"},{"key":"10424_CR20","doi-asserted-by":"crossref","unstructured":"Plantureux L et al (2018) Impacts of cancer on platelet production, activation and education and mechanisms of cancer-associated thrombosis. Cancers (Basel), 10(11)","DOI":"10.3390\/cancers10110441"},{"issue":"1","key":"10424_CR21","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/jth.13181","volume":"14","author":"JE Geddings","year":"2016","unstructured":"Geddings JE et al (2016) Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice. J Thromb Haemost 14(1):153\u2013166","journal-title":"J Thromb Haemost"},{"issue":"8","key":"10424_CR22","doi-asserted-by":"publisher","first-page":"e73609","DOI":"10.1371\/journal.pone.0073609","volume":"8","author":"S Takagi","year":"2013","unstructured":"Takagi S et al (2013) Platelets promote tumor growth and metastasis via direct interaction between Aggrus\/podoplanin and CLEC-2. PLoS ONE 8(8):e73609","journal-title":"PLoS ONE"},{"issue":"16","key":"10424_CR23","doi-asserted-by":"publisher","first-page":"9325","DOI":"10.1073\/pnas.95.16.9325","volume":"95","author":"YJ Kim","year":"1998","unstructured":"Kim YJ et al (1998) P-selectin deficiency attenuates tumor growth and metastasis. Proc Natl Acad Sci U S A 95(16):9325\u20139330","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10424_CR24","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.celrep.2018.03.092","volume":"23","author":"Y Ward","year":"2018","unstructured":"Ward Y et al (2018) Platelets promote metastasis via binding tumor CD97 leading to bidirectional signaling that coordinates transendothelial migration. Cell Rep 23(3):808\u2013822","journal-title":"Cell Rep"},{"key":"10424_CR25","doi-asserted-by":"publisher","first-page":"909767","DOI":"10.3389\/fonc.2022.909767","volume":"12","author":"W Strasenburg","year":"2022","unstructured":"Strasenburg W et al (2022) Tumor cell-induced platelet aggregation as an emerging therapeutic target for cancer therapy. Front Oncol 12:909767","journal-title":"Front Oncol"},{"issue":"6","key":"10424_CR26","first-page":"1295","volume":"59","author":"B Nieswandt","year":"1999","unstructured":"Nieswandt B et al (1999) Lysis of tumor cells by natural killer cells in mice is impeded by platelets. Cancer Res 59(6):1295\u20131300","journal-title":"Cancer Res"},{"key":"10424_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s12645-025-00340-3","author":"Jalal Naghinezhad","year":"2025","unstructured":"Naghinezhad, J., Moradpanah, S., Khodakarim, N. et al. Nanodrug-based modulation of platelet\u2013leukocyte interactions in ovarian cancer: a new frontier in targeted therapy. Cancer Nano 16, 37 (2025) https:\/\/doi.org\/10.1186\/s12645-025-00340-3","journal-title":"Cancer nanotechnology"},{"issue":"1","key":"10424_CR28","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.ccr.2013.05.008","volume":"24","author":"D Schumacher","year":"2013","unstructured":"Schumacher D et al (2013) Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. Cancer Cell 24(1):130\u2013137","journal-title":"Cancer Cell"},{"issue":"1","key":"10424_CR29","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ccr.2013.06.009","volume":"24","author":"BZ Stanger","year":"2013","unstructured":"Stanger BZ, Kahn ML (2013) Platelets and tumor cells: a new form of border control. Cancer Cell 24(1):9\u201311","journal-title":"Cancer Cell"},{"issue":"19","key":"10424_CR30","doi-asserted-by":"publisher","first-page":"7775","DOI":"10.1158\/0008-5472.CAN-09-2123","volume":"69","author":"HG Kopp","year":"2009","unstructured":"Kopp HG, Placke T, Salih HR (2009) Platelet-derived transforming growth factor-beta down-regulates NKG2D thereby inhibiting natural killer cell antitumor reactivity. Cancer Res 69(19):7775\u20137783","journal-title":"Cancer Res"},{"issue":"7","key":"10424_CR31","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1056\/NEJMoa1110352","volume":"366","author":"RL Stone","year":"2012","unstructured":"Stone RL et al (2012) Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med 366(7):610\u2013618","journal-title":"N Engl J Med"},{"issue":"3","key":"10424_CR32","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1055\/s-0043-1776005","volume":"50","author":"HG Roweth","year":"2024","unstructured":"Roweth HG (2024) Platelet contributions to the (Pre)metastatic tumor microenvironment. Semin Thromb Hemost 50(3):455\u2013461","journal-title":"Semin Thromb Hemost"},{"key":"10424_CR33","doi-asserted-by":"publisher","first-page":"642761","DOI":"10.3389\/fonc.2021.642761","volume":"11","author":"H Fabricius","year":"2021","unstructured":"Fabricius H, Starzonek S, Lange T (2021) The role of platelet cell surface P-selectin for the direct platelet-tumor cell contact during metastasis formation in human tumors. Front Oncol 11:642761","journal-title":"Front Oncol"},{"issue":"1","key":"10424_CR34","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41392-021-00817-8","volume":"6","author":"D Lin","year":"2021","unstructured":"Lin D et al (2021) Circulating tumor cells: biology and clinical significance. Signal Transduct Target Ther 6(1):404","journal-title":"Signal Transduct Target Ther"},{"issue":"5","key":"10424_CR35","first-page":"763","volume":"8","author":"Q Huang","year":"2018","unstructured":"Huang Q et al (2018) Fluid shear stress and tumor metastasis. Am J Cancer Res 8(5):763\u2013777","journal-title":"Am J Cancer Res"},{"issue":"6","key":"10424_CR36","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/s10585-014-9660-7","volume":"31","author":"K Egan","year":"2014","unstructured":"Egan K, Cooke N, Kenny D (2014) Living in shear: platelets protect cancer cells from shear induced damage. Clin Exp Metastasis 31(6):697\u2013704","journal-title":"Clin Exp Metastasis"},{"issue":"5","key":"10424_CR37","doi-asserted-by":"publisher","first-page":"C1320","DOI":"10.1152\/ajpcell.00159.2004","volume":"287","author":"K Lawler","year":"2004","unstructured":"Lawler K et al (2004) Shear stress modulates the interaction of platelet-secreted matrix proteins with tumor cells through the integrin alphavbeta3. Am J Physiol Cell Physiol 287(5):C1320\u2013C1327","journal-title":"Am J Physiol Cell Physiol"},{"key":"10424_CR38","doi-asserted-by":"crossref","unstructured":"Lim M et al (2021) Circulating tumor cell clusters are cloaked with platelets and correlate with poor prognosis in unresectable pancreatic cancer. Cancers (Basel), 13(21)","DOI":"10.3390\/cancers13215272"},{"issue":"20","key":"10424_CR39","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1039\/C7LC00654C","volume":"17","author":"X Jiang","year":"2017","unstructured":"Jiang X et al (2017) Microfluidic isolation of platelet-covered circulating tumor cells. Lab Chip 17(20):3498\u20133503","journal-title":"Lab Chip"},{"issue":"2","key":"10424_CR40","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1158\/0008-5472.CAN-11-1872","volume":"72","author":"T Placke","year":"2012","unstructured":"Placke T et al (2012) Platelet-derived MHC class I confers a pseudonormal phenotype to cancer cells that subverts the antitumor reactivity of natural killer immune cells. Cancer Res 72(2):440\u2013448","journal-title":"Cancer Res"},{"issue":"1","key":"10424_CR41","doi-asserted-by":"publisher","first-page":"19296","DOI":"10.1038\/s41598-020-76351-4","volume":"10","author":"AB Zaslavsky","year":"2020","unstructured":"Zaslavsky AB et al (2020) Platelet PD-L1 suppresses anti-cancer immune cell activity in PD-L1 negative tumors. Sci Rep 10(1):19296","journal-title":"Sci Rep"},{"key":"10424_CR42","doi-asserted-by":"publisher","first-page":"640578","DOI":"10.3389\/fimmu.2021.640578","volume":"12","author":"L Schmied","year":"2021","unstructured":"Schmied L, H\u00f6glund P, Meinke S (2021) Platelet-mediated protection of cancer cells from immune surveillance-possible implications for cancer immunotherapy. Front Immunol 12:640578","journal-title":"Front Immunol"},{"issue":"20","key":"10424_CR43","doi-asserted-by":"publisher","first-page":"5668","DOI":"10.1182\/bloodadvances.2021006120","volume":"6","author":"Q Guo","year":"2022","unstructured":"Guo Q et al (2022) Platelets upregulate tumor cell programmed death ligand 1 in an epidermal growth factor receptor-dependent manner in vitro. Blood Adv 6(20):5668\u20135675","journal-title":"Blood Adv"},{"issue":"1","key":"10424_CR44","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/s41467-017-00411-z","volume":"8","author":"M Haemmerle","year":"2017","unstructured":"Haemmerle M et al (2017) Platelets reduce anoikis and promote metastasis by activating YAP1 signaling. Nat Commun 8(1):310","journal-title":"Nat Commun"},{"key":"10424_CR45","doi-asserted-by":"publisher","first-page":"665534","DOI":"10.3389\/fonc.2021.665534","volume":"11","author":"A Braun","year":"2021","unstructured":"Braun A et al (2021) Platelet-cancer interplay: molecular mechanisms and new therapeutic avenues. Front Oncol 11:665534","journal-title":"Front Oncol"},{"issue":"7","key":"10424_CR46","doi-asserted-by":"publisher","first-page":"7822","DOI":"10.1096\/fj.201801936RRR","volume":"33","author":"Y Zhang","year":"2019","unstructured":"Zhang Y et al (2019) TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells. Faseb j 33(7):7822\u20137832","journal-title":"Faseb j"},{"issue":"2","key":"10424_CR47","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41389-020-0189-0","volume":"9","author":"E Marcolino","year":"2020","unstructured":"Marcolino E et al (2020) Blood platelets stimulate cancer extravasation through TGF\u03b2-mediated downregulation of PRH\/HHEX. Oncogenesis 9(2):10","journal-title":"Oncogenesis"},{"issue":"9","key":"10424_CR48","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1161\/ATVBAHA.124.321189","volume":"44","author":"HG Roweth","year":"2024","unstructured":"Roweth HG et al (2024) Platelet angiopoietin-1 protects against murine models of tumor metastasis. Arterioscler Thromb Vasc Biol 44(9):2024\u20132037","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"30","key":"10424_CR49","doi-asserted-by":"publisher","first-page":"E3053","DOI":"10.1073\/pnas.1411082111","volume":"111","author":"M Labelle","year":"2014","unstructured":"Labelle M, Begum S, Hynes RO (2014) Platelets guide the formation of early metastatic niches. Proc Natl Acad Sci U S A 111(30):E3053\u2013E3061","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10424_CR50","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.ccell.2016.09.011","volume":"30","author":"Y Liu","year":"2016","unstructured":"Liu Y, Cao X (2016) Characteristics and significance of the pre-metastatic niche. Cancer Cell 30(5):668\u2013681","journal-title":"Cancer Cell"},{"issue":"1","key":"10424_CR51","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/s41392-024-01937-7","volume":"9","author":"Y Wang","year":"2024","unstructured":"Wang Y et al (2024) Pre-metastatic niche: formation, characteristics and therapeutic implication. Signal Transduct Target Ther 9(1):236","journal-title":"Signal Transduct Target Ther"},{"issue":"15","key":"10424_CR52","doi-asserted-by":"publisher","first-page":"3725","DOI":"10.1158\/1078-0432.CCR-16-0028","volume":"22","author":"AR Chin","year":"2016","unstructured":"Chin AR, Wang SE (2016) Cancer tills the premetastatic field: mechanistic basis and clinical implications. Clin Cancer Res 22(15):3725\u20133733","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10424_CR53","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1182\/blood-2004-06-2272","volume":"105","author":"JS Palumbo","year":"2005","unstructured":"Palumbo JS et al (2005) Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood 105(1):178\u2013185","journal-title":"Blood"},{"issue":"2","key":"10424_CR54","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nrc3004","volume":"11","author":"LJ Gay","year":"2011","unstructured":"Gay LJ, Felding-Habermann B (2011) Contribution of platelets to tumour metastasis. Nat Rev Cancer 11(2):123\u2013134","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"10424_CR55","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1172\/JCI116654","volume":"92","author":"JP Stone","year":"1993","unstructured":"Stone JP, Wagner DD (1993) P-selectin mediates adhesion of platelets to neuroblastoma and small cell lung cancer. J Clin Invest 92(2):804\u2013813","journal-title":"J Clin Invest"},{"issue":"2","key":"10424_CR56","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00005-006-0010-6","volume":"54","author":"M Chen","year":"2006","unstructured":"Chen M, Geng JG (2006) P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis. Arch Immunol Ther Exp (Warsz) 54(2):75\u201384","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"issue":"18","key":"10424_CR57","doi-asserted-by":"publisher","first-page":"4662","DOI":"10.1158\/0008-5472.CAN-11-4010","volume":"72","author":"LA Coupland","year":"2012","unstructured":"Coupland LA, Chong BH, Parish CR (2012) Platelets and P-selectin control tumor cell metastasis in an organ-specific manner and independently of NK cells. Cancer Res 72(18):4662\u20134671","journal-title":"Cancer Res"},{"issue":"3","key":"10424_CR58","doi-asserted-by":"publisher","first-page":"e91320","DOI":"10.1371\/journal.pone.0091320","volume":"9","author":"CL Qi","year":"2014","unstructured":"Qi CL et al (2014) P-selectin-mediated platelet adhesion promotes the metastasis of murine melanoma cells. PLoS ONE 9(3):e91320","journal-title":"PLoS ONE"},{"issue":"6","key":"10424_CR59","doi-asserted-by":"publisher","first-page":"679","DOI":"10.7150\/ijbs.11589","volume":"11","author":"C Qi","year":"2015","unstructured":"Qi C et al (2015) P-selectin-mediated adhesion between platelets and tumor cells promotes intestinal tumorigenesis in Apc(Min\/+) Mice. Int J Biol Sci 11(6):679\u2013687","journal-title":"Int J Biol Sci"},{"issue":"40","key":"10424_CR60","doi-asserted-by":"publisher","first-page":"42733","DOI":"10.18632\/oncotarget.5811","volume":"6","author":"YW Chang","year":"2015","unstructured":"Chang YW et al (2015) Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis. Oncotarget 6(40):42733\u201342748","journal-title":"Oncotarget"},{"issue":"3","key":"10424_CR61","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/jth.13604","volume":"15","author":"T Shirai","year":"2017","unstructured":"Shirai T et al (2017) C-type lectin-like receptor 2 promotes hematogenous tumor metastasis and prothrombotic state in tumor-bearing mice. J Thromb Haemost 15(3):513\u2013525","journal-title":"J Thromb Haemost"},{"issue":"1","key":"10424_CR62","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1186\/s12885-024-12194-w","volume":"24","author":"M Sheng","year":"2024","unstructured":"Sheng M et al (2024) The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis. BMC Cancer 24(1):399","journal-title":"BMC Cancer"},{"issue":"10","key":"10424_CR63","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1111\/j.1538-7836.2009.03559.x","volume":"7","author":"S Jain","year":"2009","unstructured":"Jain S, Russell S, Ware J (2009) Platelet glycoprotein VI facilitates experimental lung metastasis in syngenic mouse models. J Thromb Haemost 7(10):1713\u20131717","journal-title":"J Thromb Haemost"},{"issue":"14","key":"10424_CR64","first-page":"1146","volume":"135","author":"E Mammadova-Bach","year":"2020","unstructured":"Mammadova-Bach E et al (2020) Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3. Blood 135(14):1146\u20131160","journal-title":"Blood"},{"key":"10424_CR65","doi-asserted-by":"publisher","first-page":"100325","DOI":"10.1016\/j.jbo.2020.100325","volume":"25","author":"Q Wang","year":"2020","unstructured":"Wang Q et al (2020) von Willebrand factor promotes platelet-induced metastasis of osteosarcoma through activation of the VWF-GPIb axis. J Bone Oncol 25:100325","journal-title":"J Bone Oncol"},{"issue":"6","key":"10424_CR66","doi-asserted-by":"publisher","first-page":"e70217","DOI":"10.1002\/mco2.70217","volume":"6","author":"K Zhou","year":"2025","unstructured":"Zhou K et al (2025) Glycoprotein Ib\u03b1-dependent platelet activation is essential for tumor cell-platelet interaction and experimental metastasis. MedComm (2020) 6(6):e70217","journal-title":"MedComm (2020)"},{"issue":"5","key":"10424_CR67","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1080\/09537109975915","volume":"10","author":"A Amirkhosravi","year":"1999","unstructured":"Amirkhosravi A et al (1999) Blockade of GpIIb\/IIIa inhibits the release of vascular endothelial growth factor (VEGF) from tumor cell-activated platelets and experimental metastasis. Platelets 10(5):285\u2013292","journal-title":"Platelets"},{"issue":"1","key":"10424_CR68","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s12964-019-0464-x","volume":"17","author":"XX Zuo","year":"2019","unstructured":"Zuo XX et al (2019) Platelets promote breast cancer cell MCF-7 metastasis by direct interaction: surface integrin \u03b12\u03b21-contacting-mediated activation of Wnt-\u03b2-catenin pathway. Cell Commun Signal 17(1):142","journal-title":"Cell Commun Signal"},{"issue":"4","key":"10424_CR69","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/ijc.2910330416","volume":"33","author":"G Skolnik","year":"1984","unstructured":"Skolnik G et al (1984) The importance of 5-HT for tumor cell lodgement in the liver. Int J Cancer 33(4):519\u2013523","journal-title":"Int J Cancer"},{"issue":"3","key":"10424_CR70","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0039-6060(96)80120-6","volume":"119","author":"K Anan","year":"1996","unstructured":"Anan K et al (1996) Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer. Surgery 119(3):333\u2013339","journal-title":"Surgery"},{"issue":"12","key":"10424_CR71","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1172\/JCI200422123","volume":"114","author":"A Boucharaba","year":"2004","unstructured":"Boucharaba A et al (2004) Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer. J Clin Invest 114(12):1714\u20131725","journal-title":"J Clin Invest"},{"issue":"36","key":"10424_CR72","doi-asserted-by":"publisher","first-page":"4319","DOI":"10.1038\/onc.2012.447","volume":"32","author":"BA Kerr","year":"2013","unstructured":"Kerr BA et al (2013) Platelets govern pre-metastatic tumor communication to bone. Oncogene 32(36):4319\u20134324","journal-title":"Oncogene"},{"key":"10424_CR73","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1186\/s12885-015-1304-z","volume":"15","author":"R Orellana","year":"2015","unstructured":"Orellana R et al (2015) Platelets enhance tissue factor protein and metastasis initiating cell markers, and act as chemoattractants increasing the migration of ovarian cancer cells. BMC Cancer 15:290","journal-title":"BMC Cancer"},{"issue":"18","key":"10424_CR74","doi-asserted-by":"publisher","first-page":"5611","DOI":"10.1158\/1078-0432.CCR-16-3272","volume":"23","author":"Q Hu","year":"2017","unstructured":"Hu Q et al (2017) Role of platelet-derived Tgf\u03b21 in the progression of ovarian cancer. Clin Cancer Res 23(18):5611\u20135621","journal-title":"Clin Cancer Res"},{"issue":"50","key":"10424_CR75","doi-asserted-by":"publisher","first-page":"87174","DOI":"10.18632\/oncotarget.19912","volume":"8","author":"AD He","year":"2017","unstructured":"He AD et al (2017) Platelet derived TGF-\u03b2 promotes cervical carcinoma cell growth by suppressing KLF6 expression. Oncotarget 8(50):87174\u201387181","journal-title":"Oncotarget"},{"issue":"2","key":"10424_CR76","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1182\/bloodadvances.2018026161","volume":"3","author":"KE Johnson","year":"2019","unstructured":"Johnson KE et al (2019) Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis. Blood Adv 3(2):198\u2013211","journal-title":"Blood Adv"},{"issue":"9","key":"10424_CR77","doi-asserted-by":"publisher","first-page":"107704","DOI":"10.1016\/j.isci.2023.107704","volume":"26","author":"Y Tang","year":"2023","unstructured":"Tang Y et al (2023) Activated platelets facilitate hematogenous metastasis of breast cancer by modulating the PDGFR-\u03b2\/COX-2 axis. iScience 26(9):107704","journal-title":"iScience"},{"issue":"8060","key":"10424_CR78","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1038\/s41586-025-08626-7","volume":"640","author":"J Yang","year":"2025","unstructured":"Yang J et al (2025) Aspirin prevents metastasis by limiting platelet TXA(2) suppression of T cell immunity. Nature 640(8060):1052\u20131061","journal-title":"Nature"},{"issue":"7986","key":"10424_CR79","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/s41586-023-06537-z","volume":"623","author":"N Borcherding","year":"2023","unstructured":"Borcherding N, Brestoff JR (2023) The power and potential of mitochondria transfer. Nature 623(7986):283\u2013291","journal-title":"Nature"},{"issue":"1","key":"10424_CR80","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/s41392-020-00440-z","volume":"6","author":"D Liu","year":"2021","unstructured":"Liu D et al (2021) Intercellular mitochondrial transfer as a means of tissue revitalization. Signal Transduct Target Ther 6(1):65","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"10424_CR81","doi-asserted-by":"publisher","first-page":"e3001166","DOI":"10.1371\/journal.pbio.3001166","volume":"19","author":"L Peruzzotti-Jametti","year":"2021","unstructured":"Peruzzotti-Jametti L et al (2021) Neural stem cells traffic functional mitochondria via extracellular vesicles. PLoS Biol 19(4):e3001166","journal-title":"PLoS Biol"},{"key":"10424_CR82","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/1479-5876-11-94","volume":"11","author":"J Pasquier","year":"2013","unstructured":"Pasquier J et al (2013) Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance. J Transl Med 11:94","journal-title":"J Transl Med"},{"issue":"9","key":"10424_CR83","doi-asserted-by":"publisher","first-page":"15539","DOI":"10.18632\/oncotarget.14695","volume":"8","author":"J Lu","year":"2017","unstructured":"Lu J et al (2017) Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells. Oncotarget 8(9):15539\u201315552","journal-title":"Oncotarget"},{"issue":"2","key":"10424_CR84","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1182\/blood-2015-07-655860","volume":"128","author":"R Moschoi","year":"2016","unstructured":"Moschoi R et al (2016) Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy. Blood 128(2):253\u2013264","journal-title":"Blood"},{"issue":"20","key":"10424_CR85","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.1182\/bloodadvances.2020003661","volume":"5","author":"K Saito","year":"2021","unstructured":"Saito K et al (2021) Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition. Blood Adv 5(20):4233\u20134255","journal-title":"Blood Adv"},{"issue":"1","key":"10424_CR86","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1186\/s13287-024-04079-3","volume":"15","author":"H Fu","year":"2024","unstructured":"Fu H et al (2024) CX43-mediated mitochondrial transfer maintains stemness of KG-1a leukemia stem cells through metabolic remodeling. Stem Cell Res Ther 15(1):460","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"10424_CR87","first-page":"943","volume":"76","author":"WJ Fang","year":"2024","unstructured":"Fang WJ et al (2024) [The impact of mitochondrial transfer on leukemia progression]. Sheng Li Xue Bao 76(6):943\u2013952","journal-title":"Sheng Li Xue Bao"},{"issue":"17","key":"10424_CR88","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1182\/blood.2019001398","volume":"134","author":"R Burt","year":"2019","unstructured":"Burt R et al (2019) Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress. Blood 134(17):1415\u20131429","journal-title":"Blood"},{"issue":"1","key":"10424_CR89","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13045-018-0554-z","volume":"11","author":"J Wang","year":"2018","unstructured":"Wang J et al (2018) Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells. J Hematol Oncol 11(1):11","journal-title":"J Hematol Oncol"},{"issue":"9","key":"10424_CR90","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1158\/0008-5472.CAN-19-0500","volume":"79","author":"LH Boise","year":"2019","unstructured":"Boise LH, Shanmugam M (2019) Stromal support of metabolic function through mitochondrial transfer in multiple myeloma. Cancer Res 79(9):2102\u20132103","journal-title":"Cancer Res"},{"key":"10424_CR91","doi-asserted-by":"crossref","unstructured":"Matula Z et al (2021) Stromal cells serve drug resistance for multiple myeloma via mitochondrial transfer: a study on primary myeloma and stromal cells. Cancers (Basel) 13(14)","DOI":"10.3390\/cancers13143461"},{"key":"10424_CR92","doi-asserted-by":"crossref","unstructured":"Matula Z et al (2023) The effect of belantamab mafodotin on primary myeloma-stroma co-cultures: asymmetrical mitochondrial transfer between myeloma cells and autologous bone marrow stromal cells. Int J Mol Sci 24(6)","DOI":"10.3390\/ijms24065303"},{"issue":"10","key":"10424_CR93","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.neo.2017.07.004","volume":"19","author":"HV Vangapandu","year":"2017","unstructured":"Vangapandu HV et al (2017) The stromal microenvironment modulates mitochondrial oxidative phosphorylation in chronic lymphocytic leukemia cells. Neoplasia 19(10):762\u2013771","journal-title":"Neoplasia"},{"key":"10424_CR94","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.3389\/fonc.2020.01422","volume":"10","author":"N Dubois","year":"2020","unstructured":"Dubois N et al (2020) Importance of crosstalk between chronic lymphocytic leukemia cells and the stromal microenvironment: direct contact, soluble factors, and extracellular vesicles. Front Oncol 10:1422","journal-title":"Front Oncol"},{"issue":"11","key":"10424_CR95","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/s41419-019-2045-8","volume":"10","author":"MD Kolba","year":"2019","unstructured":"Kolba MD et al (2019) Tunneling nanotube-mediated intercellular vesicle and protein transfer in the stroma-provided imatinib resistance in chronic myeloid leukemia cells. Cell Death Dis 10(11):817","journal-title":"Cell Death Dis"},{"issue":"1","key":"10424_CR96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41375-021-01416-w","volume":"36","author":"L de Beauchamp","year":"2022","unstructured":"de Beauchamp L, Himonas E, Helgason GV (2022) Mitochondrial metabolism as a potential therapeutic target in myeloid leukaemia. Leukemia 36(1):1\u201312","journal-title":"Leukemia"},{"key":"10424_CR97","doi-asserted-by":"crossref","unstructured":"Goliwas KF et al (2023) Mitochondrial transfer from cancer-associated fibroblasts increases migration in aggressive breast cancer. J Cell Sci 136(14)","DOI":"10.1242\/jcs.260419"},{"issue":"1","key":"10424_CR98","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s13046-024-03087-8","volume":"43","author":"V Del Vecchio","year":"2024","unstructured":"Del Vecchio V et al (2024) Mitochondrial transfer from Adipose stem cells to breast cancer cells drives multi-drug resistance. J Exp Clin Cancer Res 43(1):166","journal-title":"J Exp Clin Cancer Res"},{"issue":"8075","key":"10424_CR99","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/s41586-025-09176-8","volume":"644","author":"G Hoover","year":"2025","unstructured":"Hoover G et al (2025) Nerve-to-cancer transfer of mitochondria during cancer metastasis. Nature 644(8075):252\u2013262","journal-title":"Nature"},{"issue":"1","key":"10424_CR100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00702-009-0288-8","volume":"117","author":"M Guescini","year":"2010","unstructured":"Guescini M et al (2010) Astrocytes and Glioblastoma cells release exosomes carrying mtDNA. J Neural Transm (Vienna) 117(1):1\u20134","journal-title":"J Neural Transm (Vienna)"},{"issue":"12","key":"10424_CR101","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.7150\/thno.33100","volume":"9","author":"C Sun","year":"2019","unstructured":"Sun C et al (2019) Endocytosis-mediated mitochondrial transplantation: transferring normal human astrocytic mitochondria into glioma cells rescues aerobic respiration and enhances radiosensitivity. Theranostics 9(12):3595\u20133607","journal-title":"Theranostics"},{"issue":"5","key":"10424_CR102","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/s43018-023-00556-5","volume":"4","author":"DC Watson","year":"2023","unstructured":"Watson DC et al (2023) GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity. Nat Cancer 4(5):648\u2013664","journal-title":"Nat Cancer"},{"issue":"30","key":"10424_CR103","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1038\/s41388-025-03429-6","volume":"44","author":"P Brisudova","year":"2025","unstructured":"Brisudova P et al (2025) Functional mitochondrial respiration is essential for glioblastoma tumour growth. Oncogene 44(30):2588\u20132603","journal-title":"Oncogene"},{"key":"10424_CR104","doi-asserted-by":"crossref","unstructured":"Dong LF et al (2017) Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells. Elife 6","DOI":"10.7554\/eLife.22187"},{"issue":"1","key":"10424_CR105","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/s41416-020-01159-y","volume":"124","author":"PR Kumar","year":"2021","unstructured":"Kumar PR et al (2021) Mitochondrial oxidative phosphorylation in cutaneous melanoma. Br J Cancer 124(1):115\u2013123","journal-title":"Br J Cancer"},{"issue":"4","key":"10424_CR106","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1093\/bbb\/zbag004","volume":"90","author":"FC Kuo","year":"2026","unstructured":"Kuo FC et al (2026) Investigating interspecies mitochondrial transplantation on the malignancy of melanoma cells. Biosci Biotechnol Biochem 90(4):524\u2013534","journal-title":"Biosci Biotechnol Biochem"},{"issue":"8","key":"10424_CR107","doi-asserted-by":"publisher","first-page":"114551","DOI":"10.1016\/j.celrep.2024.114551","volume":"43","author":"L Frisbie","year":"2024","unstructured":"Frisbie L et al (2024) Carcinoma-associated mesenchymal stem cells promote ovarian cancer heterogeneity and metastasis through mitochondrial transfer. Cell Rep 43(8):114551","journal-title":"Cell Rep"},{"issue":"27","key":"10424_CR108","doi-asserted-by":"publisher","first-page":"5339","DOI":"10.1038\/s41388-019-0805-7","volume":"38","author":"L Ippolito","year":"2019","unstructured":"Ippolito L et al (2019) Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer. Oncogene 38(27):5339\u20135355","journal-title":"Oncogene"},{"issue":"2","key":"10424_CR109","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/s41419-024-06536-6","volume":"15","author":"M Jing","year":"2024","unstructured":"Jing M et al (2024) HMGB1 promotes mitochondrial transfer between hepatocellular carcinoma cells through RHOT1 and RAC1 under hypoxia. Cell Death Dis 15(2):155","journal-title":"Cell Death Dis"},{"key":"10424_CR110","doi-asserted-by":"crossref","unstructured":"Sasaki R et al (2025) Oxidative high mobility group box-1 accelerates mitochondrial transfer from mesenchymal stem cells to colorectal cancer cells providing cancer cell stemness. Int J Mol Sci 26(3)","DOI":"10.3390\/ijms26031192"},{"issue":"5","key":"10424_CR111","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1158\/0008-5472.CAN-25-0433","volume":"86","author":"T Liu","year":"2026","unstructured":"Liu T et al (2026) Transfer of damaged mitochondria from cancer cells to cancer-associated fibroblasts promotes tyrosine kinase inhibitor tolerance in EGFR-mutant lung cancer. Cancer Res 86(5):1215\u20131231","journal-title":"Cancer Res"},{"issue":"10","key":"10424_CR112","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1038\/s43018-025-01038-6","volume":"6","author":"M Cangkrama","year":"2025","unstructured":"Cangkrama M et al (2025) MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation. Nat Cancer 6(10):1714\u20131733","journal-title":"Nat Cancer"},{"issue":"7","key":"10424_CR113","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/cdd.2014.211","volume":"22","author":"X Wang","year":"2015","unstructured":"Wang X, Gerdes HH (2015) Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells. Cell Death Differ 22(7):1181\u20131191","journal-title":"Cell Death Differ"},{"issue":"9","key":"10424_CR114","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1002\/embj.201386030","volume":"33","author":"T Ahmad","year":"2014","unstructured":"Ahmad T et al (2014) Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy. Embo j 33(9):994\u20131010","journal-title":"Embo j"},{"key":"10424_CR115","doi-asserted-by":"crossref","unstructured":"Zamberlan M, Semenzato M (2025) Mechanisms of mitochondrial transfer through TNTs: from organelle dynamics to cellular crosstalk. Int J Mol Sci 26(21)","DOI":"10.3390\/ijms262110581"},{"issue":"9","key":"10424_CR116","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1016\/j.cmet.2021.08.002","volume":"33","author":"C Crewe","year":"2021","unstructured":"Crewe C et al (2021) Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes. Cell Metab 33(9):1853\u20131868e11","journal-title":"Cell Metab"},{"issue":"4","key":"10424_CR117","doi-asserted-by":"publisher","first-page":"e202100642","DOI":"10.1002\/cmdc.202100642","volume":"17","author":"E Abad","year":"2022","unstructured":"Abad E, Lyakhovich A (2022) Movement of mitochondria with mutant DNA through extracellular vesicles helps cancer cells acquire chemoresistance. ChemMedChem 17(4):e202100642","journal-title":"ChemMedChem"},{"key":"10424_CR118","doi-asserted-by":"publisher","first-page":"767219","DOI":"10.3389\/fnmol.2021.767219","volume":"14","author":"L Amari","year":"2021","unstructured":"Amari L, Germain M (2021) Mitochondrial extracellular vesicles-origins and roles. Front Mol Neurosci 14:767219","journal-title":"Front Mol Neurosci"},{"issue":"5","key":"10424_CR119","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1002\/stem.632","volume":"29","author":"A Acquistapace","year":"2011","unstructured":"Acquistapace A et al (2011) Human mesenchymal stem cells reprogram adult cardiomyocytes toward a progenitor-like state through partial cell fusion and mitochondria transfer. Stem Cells 29(5):812\u2013824","journal-title":"Stem Cells"},{"issue":"6","key":"10424_CR120","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/tra.12786","volume":"22","author":"RP Norris","year":"2021","unstructured":"Norris RP (2021) Transfer of mitochondria and endosomes between cells by gap junction internalization. Traffic 22(6):174\u2013179","journal-title":"Traffic"},{"issue":"1","key":"10424_CR121","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s42003-024-05964-6","volume":"7","author":"C Chen","year":"2024","unstructured":"Chen C et al (2024) Exploring the limitations of mitochondrial dye as a genuine horizontal mitochondrial transfer surrogate. Commun Biol 7(1):281","journal-title":"Commun Biol"},{"key":"10424_CR122","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ab.2017.11.008","volume":"552","author":"MV Berridge","year":"2018","unstructured":"Berridge MV et al (2018) Mitochondrial transfer between cells: methodological constraints in cell culture and animal models. Anal Biochem 552:75\u201380","journal-title":"Anal Biochem"},{"issue":"11","key":"10424_CR123","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1038\/s41556-023-01246-1","volume":"25","author":"S Tiash","year":"2023","unstructured":"Tiash S, Brestoff JR, Crewe C (2023) A guide to studying mitochondria transfer. Nat Cell Biol 25(11):1551\u20131553","journal-title":"Nat Cell Biol"},{"issue":"2","key":"10424_CR124","doi-asserted-by":"publisher","first-page":"e12404","DOI":"10.1002\/jev2.12404","volume":"13","author":"JA Welsh","year":"2024","unstructured":"Welsh JA et al (2024) Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles 13(2):e12404","journal-title":"J Extracell Vesicles"},{"issue":"5","key":"10424_CR125","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/s41417-024-00759-7","volume":"31","author":"M Samuels","year":"2024","unstructured":"Samuels M, Giamas G (2024) MISEV2023: shaping the future of EV research by enhancing rigour, reproducibility and transparency. Cancer Gene Ther 31(5):649\u2013651","journal-title":"Cancer Gene Ther"},{"issue":"7","key":"10424_CR126","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1038\/cdd.2017.51","volume":"24","author":"M Mahrouf-Yorgov","year":"2017","unstructured":"Mahrouf-Yorgov M et al (2017) Mesenchymal stem cells sense mitochondria released from damaged cells as danger signals to activate their rescue properties. Cell Death Differ 24(7):1224\u20131238","journal-title":"Cell Death Differ"},{"issue":"28","key":"10424_CR127","doi-asserted-by":"publisher","first-page":"43150","DOI":"10.18632\/oncotarget.9504","volume":"7","author":"S Desir","year":"2016","unstructured":"Desir S et al (2016) Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells. Oncotarget 7(28):43150\u201343161","journal-title":"Oncotarget"},{"issue":"14","key":"10424_CR128","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1182\/blood-2017-03-772939","volume":"130","author":"CR Marlein","year":"2017","unstructured":"Marlein CR et al (2017) NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts. Blood 130(14):1649\u20131660","journal-title":"Blood"},{"key":"10424_CR129","doi-asserted-by":"crossref","unstructured":"Babenko VA et al (2018) Miro1 enhances mitochondria transfer from multipotent mesenchymal stem cells (MMSC) to neural cells and improves the efficacy of cell recovery. Molecules, 23(3)","DOI":"10.3390\/molecules23030687"},{"issue":"9","key":"10424_CR130","doi-asserted-by":"publisher","first-page":"e37352","DOI":"10.1097\/MD.0000000000037352","volume":"103","author":"Y Chen","year":"2024","unstructured":"Chen Y, Xiao D, Li X (2024) The role of mitochondrial transfer via tunneling nanotubes in the central nervous system: A review. Med (Baltim) 103(9):e37352","journal-title":"Med (Baltim)"},{"key":"10424_CR131","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1038\/ncomms2202","volume":"3","author":"O Dmytriyeva","year":"2012","unstructured":"Dmytriyeva O et al (2012) The metastasis-promoting S100A4 protein confers neuroprotection in brain injury. Nat Commun 3:1197","journal-title":"Nat Commun"},{"key":"10424_CR132","doi-asserted-by":"publisher","first-page":"653322","DOI":"10.3389\/fcell.2021.653322","volume":"9","author":"MO Gomzikova","year":"2021","unstructured":"Gomzikova MO, James V, Rizvanov AA (2021) Mitochondria donation by mesenchymal stem cells: current understanding and mitochondria transplantation strategies. Front Cell Dev Biol 9:653322","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"10424_CR133","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41389-022-00380-z","volume":"11","author":"C Giallongo","year":"2022","unstructured":"Giallongo C et al (2022) CXCL12\/CXCR4 axis supports mitochondrial trafficking in tumor myeloma microenvironment. Oncogenesis 11(1):6","journal-title":"Oncogenesis"},{"key":"10424_CR134","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.actbio.2025.12.048","volume":"212","author":"Y Du","year":"2026","unstructured":"Du Y et al (2026) Mitochondrial transfer through tunneling nanotubes inspires an innovative strategy for intercellular drug delivery. Acta Biomater 212:671\u2013684","journal-title":"Acta Biomater"},{"issue":"1","key":"10424_CR135","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s13287-020-01704-9","volume":"11","author":"Y Guo","year":"2020","unstructured":"Guo Y et al (2020) Mitochondria transfer enhances proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cell and promotes bone defect healing. Stem Cell Res Ther 11(1):245","journal-title":"Stem Cell Res Ther"},{"issue":"11","key":"10424_CR136","doi-asserted-by":"publisher","first-page":"e2467","DOI":"10.1038\/cddis.2016.358","volume":"7","author":"D Jiang","year":"2016","unstructured":"Jiang D et al (2016) Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage. Cell Death Dis 7(11):e2467","journal-title":"Cell Death Dis"},{"issue":"1","key":"10424_CR137","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s40364-023-00529-x","volume":"11","author":"X Guo","year":"2023","unstructured":"Guo X et al (2023) Mitochondrial transfer in hematological malignancies. Biomark Res 11(1):89","journal-title":"Biomark Res"},{"key":"10424_CR138","doi-asserted-by":"crossref","unstructured":"Kidwell CU et al (2023) Transferred mitochondria accumulate reactive oxygen species, promoting proliferation. Elife, 12","DOI":"10.7554\/eLife.85494"},{"key":"10424_CR139","doi-asserted-by":"crossref","unstructured":"Zampieri LX et al (2021) Mitochondrial transfer in cancer: a comprehensive review. Int J Mol Sci 22(6)","DOI":"10.3390\/ijms22063245"},{"issue":"8","key":"10424_CR140","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1093\/stcltm\/szac044","volume":"11","author":"YL Tan","year":"2022","unstructured":"Tan YL et al (2022) Mesenchymal stromal cell mitochondrial transfer as a cell rescue strategy in regenerative medicine: a review of evidence in preclinical models. Stem Cells Transl Med 11(8):814\u2013827","journal-title":"Stem Cells Transl Med"},{"issue":"14","key":"10424_CR141","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1182\/blood-2014-05-573543","volume":"124","author":"LH Boudreau","year":"2014","unstructured":"Boudreau LH et al (2014) Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. Blood 124(14):2173\u20132183","journal-title":"Blood"},{"issue":"10","key":"10424_CR142","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1111\/trf.17524","volume":"63","author":"M Pelletier","year":"2023","unstructured":"Pelletier M et al (2023) Platelet extracellular vesicles and their mitochondrial content improve the mitochondrial bioenergetics of cellular immune recipients. Transfusion 63(10):1983\u20131996","journal-title":"Transfusion"},{"key":"10424_CR143","doi-asserted-by":"crossref","unstructured":"Ishino T et al (2025) Mitochondrial transfer at the crossroads of cancer, stromal, and immune cells. Trends Cell Biol","DOI":"10.1016\/j.tcb.2025.10.004"},{"issue":"1","key":"10424_CR144","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41392-025-02311-x","volume":"10","author":"H Du","year":"2025","unstructured":"Du H et al (2025) Mitochondrial metabolism and cancer therapeutic innovation. Signal Transduct Target Ther 10(1):245","journal-title":"Signal Transduct Target Ther"},{"key":"10424_CR145","doi-asserted-by":"crossref","unstructured":"Braganza A et al (2019) Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight 5(13)","DOI":"10.1172\/jci.insight.128248"},{"issue":"9","key":"10424_CR146","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1182\/blood.2019000200","volume":"134","author":"P Davizon-Castillo","year":"2019","unstructured":"Davizon-Castillo P et al (2019) TNF-\u03b1-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. Blood 134(9):727\u2013740","journal-title":"Blood"},{"key":"10424_CR147","doi-asserted-by":"publisher","first-page":"122846","DOI":"10.1016\/j.lfs.2024.122846","volume":"351","author":"D Arauna","year":"2024","unstructured":"Arauna D et al (2024) Altered dynamics of calcium fluxes and mitochondrial metabolism in platelet activation-related disease and aging. Life Sci 351:122846","journal-title":"Life Sci"},{"issue":"4","key":"10424_CR148","doi-asserted-by":"publisher","first-page":"H1480","DOI":"10.1152\/ajpheart.2001.280.4.H1480","volume":"280","author":"Y Li","year":"2001","unstructured":"Li Y, Woo V, Bose R (2001) Platelet hyperactivity and abnormal Ca(2+) homeostasis in diabetes mellitus. Am J Physiol Heart Circ Physiol 280(4):H1480\u2013H1489","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"10424_CR149","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1007\/s11892-002-0020-7","volume":"2","author":"M Trovati","year":"2002","unstructured":"Trovati M, Anfossi G (2002) Mechanisms involved in platelet hyperactivation and platelet-endothelium interrelationships in diabetes mellitus. Curr Diab Rep 2(4):316\u2013322","journal-title":"Curr Diab Rep"},{"issue":"6","key":"10424_CR150","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1042\/BST20170291","volume":"45","author":"L Wang","year":"2017","unstructured":"Wang L et al (2017) Platelet mitochondrial dysfunction and the correlation with human diseases. Biochem Soc Trans 45(6):1213\u20131223","journal-title":"Biochem Soc Trans"},{"issue":"8","key":"10424_CR151","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1111\/1440-1681.12589","volume":"43","author":"NR Leite","year":"2016","unstructured":"Leite NR et al (2016) Platelet hyperaggregability in obesity: Is there a role for nitric oxide impairment and oxidative stress? Clin Exp Pharmacol Physiol 43(8):738\u2013744","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"10","key":"10424_CR152","doi-asserted-by":"publisher","first-page":"165838","DOI":"10.1016\/j.bbadis.2020.165838","volume":"1866","author":"P Prasun","year":"2020","unstructured":"Prasun P (2020) Mitochondrial dysfunction in metabolic syndrome. Biochim Biophys Acta Mol Basis Dis 1866(10):165838","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"3","key":"10424_CR153","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1053\/j.seminoncol.2014.04.015","volume":"41","author":"N van Es","year":"2014","unstructured":"van Es N et al (2014) Effects of cancer on platelets. Semin Oncol 41(3):311\u2013318","journal-title":"Semin Oncol"},{"issue":"6","key":"10424_CR154","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/S0002-9343(99)80013-8","volume":"98","author":"Z Estrov","year":"1995","unstructured":"Estrov Z et al (1995) Elevated plasma thrombopoietic activity in patients with metastatic cancer-related thrombocytosis. Am J Med 98(6):551\u2013558","journal-title":"Am J Med"},{"issue":"12","key":"10424_CR155","doi-asserted-by":"publisher","first-page":"8326","DOI":"10.1128\/MCB.19.12.8326","volume":"19","author":"JM Pasquet","year":"1999","unstructured":"Pasquet JM et al (1999) LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI. Mol Cell Biol 19(12):8326\u20138334","journal-title":"Mol Cell Biol"},{"issue":"12","key":"10424_CR156","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1111\/j.1538-7836.2008.03166.x","volume":"6","author":"CE Hughes","year":"2008","unstructured":"Hughes CE et al (2008) Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2. J Thromb Haemost 6(12):2152\u20132159","journal-title":"J Thromb Haemost"},{"issue":"3","key":"10424_CR157","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1042\/BJ20040654","volume":"383","author":"GE Jarvis","year":"2004","unstructured":"Jarvis GE, Best D, Watson SP (2004) Glycoprotein VI\/Fc receptor gamma chain-independent tyrosine phosphorylation and activation of murine platelets by collagen. Biochem J 383(3):581\u2013588","journal-title":"Biochem J"},{"issue":"10","key":"10424_CR158","doi-asserted-by":"publisher","first-page":"4069","DOI":"10.1182\/blood-2008-05-157883","volume":"112","author":"JE Purvis","year":"2008","unstructured":"Purvis JE et al (2008) A molecular signaling model of platelet phosphoinositide and calcium regulation during homeostasis and P2Y1 activation. Blood 112(10):4069\u20134079","journal-title":"Blood"},{"issue":"7","key":"10424_CR159","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1083\/jcb.200207119","volume":"160","author":"WS Nesbitt","year":"2003","unstructured":"Nesbitt WS et al (2003) Intercellular calcium communication regulates platelet aggregation and thrombus growth. J Cell Biol 160(7):1151\u20131161","journal-title":"J Cell Biol"},{"issue":"5","key":"10424_CR160","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.3324\/haematol.2021.279847","volume":"107","author":"PP Kulkarni","year":"2022","unstructured":"Kulkarni PP et al (2022) Mitochondrial ATP generation in stimulated platelets is essential for granule secretion but dispensable for aggregation and procoagulant activity. Haematologica 107(5):1209\u20131213","journal-title":"Haematologica"},{"issue":"5","key":"10424_CR161","doi-asserted-by":"publisher","first-page":"569","DOI":"10.15252\/emmm.201606255","volume":"8","author":"A Tosatto","year":"2016","unstructured":"Tosatto A et al (2016) The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1\u03b1. EMBO Mol Med 8(5):569\u2013585","journal-title":"EMBO Mol Med"},{"issue":"12","key":"10424_CR162","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1158\/0008-5472.CAN-21-3230","volume":"82","author":"X Wang","year":"2022","unstructured":"Wang X et al (2022) Mitochondrial calcium uniporter drives metastasis and confers a targetable cystine dependency in pancreatic cancer. Cancer Res 82(12):2254\u20132268","journal-title":"Cancer Res"},{"key":"10424_CR163","doi-asserted-by":"publisher","first-page":"102759","DOI":"10.1016\/j.redox.2023.102759","volume":"64","author":"A Weiser","year":"2023","unstructured":"Weiser A et al (2023) The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state. Redox Biol 64:102759","journal-title":"Redox Biol"},{"issue":"2","key":"10424_CR164","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ccr.2008.12.019","volume":"15","author":"S Yang","year":"2009","unstructured":"Yang S, Zhang JJ, Huang XY (2009) Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell 15(2):124\u2013134","journal-title":"Cancer Cell"},{"issue":"1","key":"10424_CR165","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s13287-024-03875-1","volume":"15","author":"D Zhuo","year":"2024","unstructured":"Zhuo D et al (2024) Orai1 and Orai3 act through distinct signalling axes to promote stemness and tumorigenicity of breast cancer stem cells. Stem Cell Res Ther 15(1):256","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10424_CR166","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1096\/fj.12-213801","volume":"27","author":"RK Motiani","year":"2013","unstructured":"Motiani RK et al (2013) Orai3 is an estrogen receptor \u03b1-regulated Ca\u00b2\u207a channel that promotes tumorigenesis. Faseb j 27(1):63\u201375","journal-title":"Faseb j"},{"key":"10424_CR167","doi-asserted-by":"crossref","unstructured":"McLelland GL et al (2018) Mfn2 ubiquitination by PINK1\/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. Elife 7","DOI":"10.7554\/eLife.32866"},{"issue":"1","key":"10424_CR168","doi-asserted-by":"publisher","first-page":"5202","DOI":"10.1038\/s41467-023-40929-z","volume":"14","author":"SJ Ham","year":"2023","unstructured":"Ham SJ et al (2023) PINK1 and Parkin regulate IP(3)R-mediated ER calcium release. Nat Commun 14(1):5202","journal-title":"Nat Commun"},{"issue":"1","key":"10424_CR169","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41420-022-01263-3","volume":"8","author":"M Vismara","year":"2022","unstructured":"Vismara M et al (2022) Proteomic and functional profiling of platelet-derived extracellular vesicles released under physiological or tumor-associated conditions. Cell Death Discov 8(1):467","journal-title":"Cell Death Discov"},{"issue":"1","key":"10424_CR170","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1186\/s13287-024-03932-9","volume":"15","author":"RM Irwin","year":"2024","unstructured":"Irwin RM et al (2024) Connexin 43 regulates intercellular mitochondrial transfer from human mesenchymal stromal cells to chondrocytes. Stem Cell Res Ther 15(1):359","journal-title":"Stem Cell Res Ther"},{"key":"10424_CR171","doi-asserted-by":"publisher","first-page":"928934","DOI":"10.3389\/fphys.2022.928934","volume":"13","author":"K Boengler","year":"2022","unstructured":"Boengler K et al (2022) Connexin 43 in mitochondria: What do we really know about its function? Front Physiol 13:928934","journal-title":"Front Physiol"},{"issue":"6131","key":"10424_CR172","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1126\/science.1231031","volume":"340","author":"Y Chen","year":"2013","unstructured":"Chen Y, Dorn GW (2013) 2nd, PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science 340(6131):471\u2013475","journal-title":"Science"},{"issue":"4","key":"10424_CR173","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1007\/s10555-024-10211-9","volume":"43","author":"F Chen","year":"2024","unstructured":"Chen F et al (2024) The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy. Cancer Metastasis Rev 43(4):1419\u20131443","journal-title":"Cancer Metastasis Rev"},{"issue":"5","key":"10424_CR174","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1182\/blood-2016-11-751099","volume":"130","author":"JV Michael","year":"2017","unstructured":"Michael JV et al (2017) Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth. Blood 130(5):567\u2013580","journal-title":"Blood"},{"issue":"1","key":"10424_CR175","doi-asserted-by":"publisher","first-page":"e1533","DOI":"10.1002\/ctm2.1533","volume":"14","author":"H Zhang","year":"2024","unstructured":"Zhang H, Li B (2024) A novel computational tool for tracking cancer energy hijacking from immune cells. Clin Transl Med 14(1):e1533","journal-title":"Clin Transl Med"},{"issue":"10","key":"10424_CR176","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1016\/j.ccell.2023.09.003","volume":"41","author":"H Zhang","year":"2023","unstructured":"Zhang H et al (2023) Systematic investigation of mitochondrial transfer between cancer cells and T cells at single-cell resolution. Cancer Cell 41(10):1788\u20131802e10","journal-title":"Cancer Cell"},{"issue":"1","key":"10424_CR177","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s40364-024-00639-0","volume":"12","author":"T Zhuang","year":"2024","unstructured":"Zhuang T et al (2024) Current status and future perspectives of platelet-derived extracellular vesicles in cancer diagnosis and treatment. Biomark Res 12(1):88","journal-title":"Biomark Res"},{"key":"10424_CR178","doi-asserted-by":"crossref","unstructured":"Sahinbegovic H et al (2020) Intercellular mitochondrial transfer in the tumor microenvironment. Cancers (Basel) 12(7)","DOI":"10.3390\/cancers12071787"},{"issue":"1","key":"10424_CR179","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s13046-024-03069-w","volume":"43","author":"F Guan","year":"2024","unstructured":"Guan F et al (2024) Mitochondrial transfer in tunneling nanotubes-a new target for cancer therapy. J Exp Clin Cancer Res 43(1):147","journal-title":"J Exp Clin Cancer Res"},{"issue":"2","key":"10424_CR180","doi-asserted-by":"publisher","first-page":"589","DOI":"10.3324\/haematol.2019.242974","volume":"106","author":"JJ Mistry","year":"2021","unstructured":"Mistry JJ et al (2021) Daratumumab inhibits acute myeloid leukaemia metabolic capacity by blocking mitochondrial transfer from mesenchymal stromal cells. Haematologica 106(2):589\u2013592","journal-title":"Haematologica"},{"issue":"6","key":"10424_CR181","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1158\/2767-9764.CRC-23-0144","volume":"3","author":"J Nakhle","year":"2023","unstructured":"Nakhle J et al (2023) Mitochondria transfer from mesenchymal stem cells confers chemoresistance to glioblastoma stem cells through metabolic rewiring. Cancer Res Commun 3(6):1041\u20131056","journal-title":"Cancer Res Commun"},{"issue":"1","key":"10424_CR182","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41416-022-01783-w","volume":"127","author":"PR Kumar","year":"2022","unstructured":"Kumar PR et al (2022) PGC-1\u03b1 induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma. Br J Cancer 127(1):69\u201378","journal-title":"Br J Cancer"},{"key":"10424_CR183","doi-asserted-by":"crossref","unstructured":"Kuo FC et al (2024) Endothelial mitochondria transfer to melanoma induces M2-type macrophage polarization and promotes tumor growth by the Nrf2\/HO-1-mediated pathway. Int J Mol Sci 25(3)","DOI":"10.3390\/ijms25031857"},{"issue":"1","key":"10424_CR184","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s41565-021-01000-4","volume":"17","author":"T Saha","year":"2022","unstructured":"Saha T et al (2022) Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells. Nat Nanotechnol 17(1):98\u2013106","journal-title":"Nat Nanotechnol"},{"issue":"23","key":"10424_CR185","doi-asserted-by":"publisher","first-page":"6614","DOI":"10.1016\/j.cell.2024.08.029","volume":"187","author":"JG Baldwin","year":"2024","unstructured":"Baldwin JG et al (2024) Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy. Cell 187(23):6614\u20136630e21","journal-title":"Cell"},{"issue":"11","key":"10424_CR186","doi-asserted-by":"publisher","first-page":"3665","DOI":"10.1016\/j.jtha.2025.08.004","volume":"23","author":"HE Allan","year":"2025","unstructured":"Allan HE et al (2025) Platelet mitochondrial transfer via extracellular vesicles modulates neutrophil phenotype and function. J Thromb Haemost 23(11):3665\u20133677","journal-title":"J Thromb Haemost"},{"issue":"2","key":"10424_CR187","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.cmet.2020.12.006","volume":"33","author":"J Levoux","year":"2021","unstructured":"Levoux J et al (2021) Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming. Cell Metab 33(2):283\u2013299e9","journal-title":"Cell Metab"},{"key":"10424_CR188","doi-asserted-by":"publisher","first-page":"217044","DOI":"10.1016\/j.canlet.2024.217044","volume":"607","author":"S Bravaccini","year":"2024","unstructured":"Bravaccini S et al (2024) The use of platelets as a clinical tool in oncology: opportunities and challenges. Cancer Lett 607:217044","journal-title":"Cancer Lett"},{"issue":"3","key":"10424_CR189","doi-asserted-by":"publisher","first-page":"3391","DOI":"10.3390\/curroncol30030258","volume":"30","author":"P Detopoulou","year":"2023","unstructured":"Detopoulou P et al (2023) Relation of mean platelet volume (MPV) with cancer: a systematic review with a focus on disease outcome on twelve types of cancer. Curr Oncol 30(3):3391\u20133420","journal-title":"Curr Oncol"},{"issue":"3","key":"10424_CR190","doi-asserted-by":"publisher","first-page":"300060522108487","DOI":"10.1177\/03000605221084874","volume":"50","author":"S Kharel","year":"2022","unstructured":"Kharel S et al (2022) Prognostic significance of mean platelet volume in patients with lung cancer: a meta-analysis. J Int Med Res 50(3):3000605221084874","journal-title":"J Int Med Res"},{"key":"10424_CR191","doi-asserted-by":"publisher","first-page":"983724","DOI":"10.3389\/fonc.2022.983724","volume":"12","author":"M Chen","year":"2022","unstructured":"Chen M et al (2022) Platelet detection as a new liquid biopsy tool for human cancers. Front Oncol 12:983724","journal-title":"Front Oncol"},{"issue":"5","key":"10424_CR192","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.31557\/APJCP.2021.22.5.1573","volume":"22","author":"M Haghbin","year":"2021","unstructured":"Haghbin M et al (2021) Platelet-derived procoagulant microparticles as blood-based biomarker of breast cancer. Asian Pac J Cancer Prev 22(5):1573\u20131579","journal-title":"Asian Pac J Cancer Prev"},{"issue":"10","key":"10424_CR193","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1111\/trf.17499","volume":"63","author":"X Li","year":"2023","unstructured":"Li X et al (2023) Platelet membrane-derived microparticles may be biomarkers in patients with hepatocellular carcinoma and can promote the invasion and metastasis of hepatoma carcinoma cells. Transfusion 63(10):1821\u20131831","journal-title":"Transfusion"},{"issue":"1","key":"10424_CR194","doi-asserted-by":"publisher","first-page":"39","DOI":"10.34172\/apb.2021.005","volume":"11","author":"M Nazari","year":"2021","unstructured":"Nazari M et al (2021) Platelet microparticle controversial role in cancer. Adv Pharm Bull 11(1):39\u201355","journal-title":"Adv Pharm Bull"},{"issue":"23","key":"10424_CR195","doi-asserted-by":"publisher","first-page":"3192","DOI":"10.1182\/blood.2019004119","volume":"137","author":"S Lazar","year":"2021","unstructured":"Lazar S, Goldfinger LE (2021) Platelets and extracellular vesicles and their cross talk with cancer. Blood 137(23):3192\u20133200","journal-title":"Blood"},{"issue":"5","key":"10424_CR196","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.ccell.2015.09.018","volume":"28","author":"MG Best","year":"2015","unstructured":"Best MG et al (2015) RNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics. Cancer Cell 28(5):666\u2013676","journal-title":"Cancer Cell"},{"issue":"9","key":"10424_CR197","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.ccell.2022.08.006","volume":"40","author":"S in \u2018t Veld","year":"2022","unstructured":"in \u2018t Veld S et al (2022) Detection and localization of early- and late-stage cancers using platelet RNA. Cancer Cell 40(9):999\u20131009e6","journal-title":"Cancer Cell"},{"issue":"8","key":"10424_CR198","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1038\/s41416-023-02174-5","volume":"128","author":"MC Liefaard","year":"2023","unstructured":"Liefaard MC et al (2023) Tumour-educated platelets for breast cancer detection: biological and technical insights. Br J Cancer 128(8):1572\u20131581","journal-title":"Br J Cancer"},{"issue":"1","key":"10424_CR199","doi-asserted-by":"publisher","first-page":"9359","DOI":"10.1038\/s41598-023-35818-w","volume":"13","author":"M Antunes-Ferreira","year":"2023","unstructured":"Antunes-Ferreira M et al (2023) Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management. Sci Rep 13(1):9359","journal-title":"Sci Rep"},{"issue":"1","key":"10424_CR200","doi-asserted-by":"publisher","first-page":"1713526","DOI":"10.1080\/20013078.2020.1713526","volume":"9","author":"JA Welsh","year":"2020","unstructured":"Welsh JA et al (2020) MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments. J Extracell Vesicles 9(1):1713526","journal-title":"J Extracell Vesicles"},{"issue":"5","key":"10424_CR201","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/s41571-020-00457-x","volume":"18","author":"M Ignatiadis","year":"2021","unstructured":"Ignatiadis M, Sledge GW, Jeffrey SS (2021) Liquid biopsy enters the clinic-implementation issues and future challenges. Nat Rev Clin Oncol 18(5):297\u2013312","journal-title":"Nat Rev Clin Oncol"},{"issue":"2","key":"10424_CR202","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41576-018-0071-5","volume":"20","author":"E Heitzer","year":"2019","unstructured":"Heitzer E et al (2019) Current and future perspectives of liquid biopsies in genomics-driven oncology. Nat Rev Genet 20(2):71\u201388","journal-title":"Nat Rev Genet"},{"key":"10424_CR203","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.mito.2018.12.003","volume":"47","author":"J Afrifa","year":"2019","unstructured":"Afrifa J, Zhao T, Yu J (2019) Circulating mitochondria DNA, a non-invasive cancer diagnostic biomarker candidate. Mitochondrion 47:238\u2013243","journal-title":"Mitochondrion"},{"issue":"2","key":"10424_CR204","first-page":"105","volume":"21","author":"F Peng","year":"2023","unstructured":"Peng F et al (2023) Circulating cell-free mtDNA as a new biomarker for cancer detection and management. Cancer Biol Med 21(2):105\u2013110","journal-title":"Cancer Biol Med"},{"issue":"1","key":"10424_CR205","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/s13059-023-03074-w","volume":"24","author":"Y van der Pol","year":"2023","unstructured":"van der Pol Y et al (2023) The landscape of cell-free mitochondrial DNA in liquid biopsy for cancer detection. Genome Biol 24(1):229","journal-title":"Genome Biol"},{"key":"10424_CR206","doi-asserted-by":"publisher","first-page":"100570","DOI":"10.1016\/j.clinsp.2024.100570","volume":"80","author":"AG Murillo Carrasco","year":"2025","unstructured":"Murillo Carrasco AG, Chammas R, Furuya TK (2025) Mitochondrial DNA alterations in precision oncology: Emerging roles in diagnostics and therapeutics. Clin (Sao Paulo) 80:100570","journal-title":"Clin (Sao Paulo)"},{"issue":"6","key":"10424_CR207","first-page":"7074","volume":"16","author":"J Chen","year":"2018","unstructured":"Chen J et al (2018) Clinical application of plasma mitochondrial DNA content in patients with lung cancer. Oncol Lett 16(6):7074\u20137081","journal-title":"Oncol Lett"},{"issue":"12","key":"10424_CR208","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1038\/s44321-024-00163-6","volume":"16","author":"Y Liu","year":"2024","unstructured":"Liu Y et al (2024) Aberrant fragmentomic features of circulating cell-free mitochondrial DNA as novel biomarkers for multi-cancer detection. EMBO Mol Med 16(12):3169\u20133183","journal-title":"EMBO Mol Med"},{"issue":"1","key":"10424_CR209","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3350\/cmh.2024.0527","volume":"31","author":"Y Liu","year":"2025","unstructured":"Liu Y et al (2025) Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma. Clin Mol Hepatol 31(1):196\u2013212","journal-title":"Clin Mol Hepatol"},{"issue":"1","key":"10424_CR210","doi-asserted-by":"publisher","first-page":"1635420","DOI":"10.1080\/20013078.2019.1635420","volume":"8","author":"SC Jang","year":"2019","unstructured":"Jang SC et al (2019) Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma. J Extracell Vesicles 8(1):1635420","journal-title":"J Extracell Vesicles"},{"issue":"1","key":"10424_CR211","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1038\/s41467-021-21984-w","volume":"12","author":"K Todkar","year":"2021","unstructured":"Todkar K et al (2021) Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs. Nat Commun 12(1):1971","journal-title":"Nat Commun"},{"issue":"9","key":"10424_CR212","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.tem.2023.06.004","volume":"34","author":"MS Wilkinson","year":"2023","unstructured":"Wilkinson MS, Dunham-Snary KJ (2023) Blood-based bioenergetics: a liquid biopsy of mitochondrial dysfunction in disease. Trends Endocrinol Metab 34(9):554\u2013570","journal-title":"Trends Endocrinol Metab"},{"key":"10424_CR213","doi-asserted-by":"crossref","unstructured":"Palacka P et al (2021) Platelet mitochondrial bioenergetics reprogramming in patients with urothelial carcinoma. Int J Mol Sci 23(1)","DOI":"10.3390\/ijms23010388"},{"issue":"3","key":"10424_CR214","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.amjsurg.2004.11.014","volume":"189","author":"KM Brown","year":"2005","unstructured":"Brown KM et al (2005) Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinoma of the pancreas. Am J Surg 189(3):278\u2013282","journal-title":"Am J Surg"},{"issue":"1","key":"10424_CR215","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.lungcan.2013.08.020","volume":"83","author":"N Inagaki","year":"2014","unstructured":"Inagaki N et al (2014) Prognostic impact of the mean platelet volume\/platelet count ratio in terms of survival in advanced non-small cell lung cancer. Lung Cancer 83(1):97\u2013101","journal-title":"Lung Cancer"},{"issue":"17","key":"10424_CR216","doi-asserted-by":"publisher","first-page":"7599","DOI":"10.7314\/APJCP.2015.16.17.7599","volume":"16","author":"M Oncel","year":"2015","unstructured":"Oncel M et al (2015) Evaluation of platelet indices in lung cancer patients. Asian Pac J Cancer Prev 16(17):7599\u20137602","journal-title":"Asian Pac J Cancer Prev"},{"issue":"5","key":"10424_CR217","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1007\/s12282-015-0635-6","volume":"23","author":"M Gu","year":"2016","unstructured":"Gu M et al (2016) Pre-treatment mean platelet volume associates with worse clinicopathologic features and prognosis of patients with invasive breast cancer. Breast Cancer 23(5):752\u2013760","journal-title":"Breast Cancer"},{"issue":"4","key":"10424_CR218","first-page":"840","volume":"21","author":"O Tanriverdi","year":"2016","unstructured":"Tanriverdi O et al (2016) The mean platelet volume may predict the development of isolated bone metastases in patients with breast cancer: a retrospective study of the young researchers committee of the Turkish Oncology Group (TOG). J buon 21(4):840\u2013850","journal-title":"J buon"},{"issue":"2","key":"10424_CR219","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.3892\/ol.2016.4760","volume":"12","author":"D Mantas","year":"2016","unstructured":"Mantas D et al (2016) White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma. Oncol Lett 12(2):1610\u20131614","journal-title":"Oncol Lett"},{"issue":"1","key":"10424_CR220","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.1038\/s41598-017-03212-y","volume":"7","author":"N Li","year":"2017","unstructured":"Li N et al (2017) Increased platelet distribution width predicts poor prognosis in melanoma patients. Sci Rep 7(1):2970","journal-title":"Sci Rep"},{"issue":"8","key":"10424_CR221","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1080\/09537104.2019.1572879","volume":"30","author":"S Rachidi","year":"2019","unstructured":"Rachidi S, Md P et al (2019) Platelet count correlates with stage and predicts survival in melanoma. Platelets 30(8):1042\u20131046","journal-title":"Platelets"},{"issue":"1","key":"10424_CR222","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12885-018-5252-2","volume":"19","author":"J Chang","year":"2019","unstructured":"Chang J et al (2019) Decreased mean platelet volume predicts poor prognosis in metastatic colorectal cancer patients treated with first-line chemotherapy: results from mCRC biomarker study. BMC Cancer 19(1):15","journal-title":"BMC Cancer"},{"issue":"1","key":"10424_CR223","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1186\/s12885-019-5504-9","volume":"19","author":"YY Wu","year":"2019","unstructured":"Wu YY et al (2019) Mean platelet volume\/platelet count ratio in colorectal cancer: a retrospective clinical study. BMC Cancer 19(1):314","journal-title":"BMC Cancer"},{"issue":"1","key":"10424_CR224","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1186\/s12885-022-09754-3","volume":"22","author":"WJ Huang","year":"2022","unstructured":"Huang WJ et al (2022) Preoperative PDW levels predict pulmonary metastasis in patients with hepatocellular carcinoma. BMC Cancer 22(1):683","journal-title":"BMC Cancer"},{"key":"10424_CR225","doi-asserted-by":"publisher","first-page":"153303382110729","DOI":"10.1177\/15330338211072974","volume":"21","author":"R Su","year":"2022","unstructured":"Su R et al (2022) Prognostic significance of platelet (PLT) and platelet to mean platelet volume (PLT\/MPV) ratio during apatinib second-line or late-line treatment in advanced esophageal squamous cell carcinoma patients. Technol Cancer Res Treat 21:15330338211072974","journal-title":"Technol Cancer Res Treat"},{"key":"10424_CR226","doi-asserted-by":"publisher","first-page":"8143","DOI":"10.2147\/OTT.S177384","volume":"11","author":"M Sheng","year":"2018","unstructured":"Sheng M, Dong Z, Xie Y (2018) Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer. Onco Targets Ther 11:8143\u20138151","journal-title":"Onco Targets Ther"},{"issue":"6","key":"10424_CR227","doi-asserted-by":"publisher","first-page":"e23791","DOI":"10.1002\/jcla.23791","volume":"35","author":"X Ge","year":"2021","unstructured":"Ge X et al (2021) Identification of seven tumor-educated platelets RNAs for cancer diagnosis. J Clin Lab Anal 35(6):e23791","journal-title":"J Clin Lab Anal"},{"issue":"1","key":"10424_CR228","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1186\/s12967-023-04417-8","volume":"21","author":"F Campolo","year":"2023","unstructured":"Campolo F et al (2023) Platelet-derived circRNAs signature in patients with gastroenteropancreatic neuroendocrine tumors. J Transl Med 21(1):548","journal-title":"J Transl Med"},{"issue":"10","key":"10424_CR229","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.1002\/1878-0261.13014","volume":"15","author":"K Pastuszak","year":"2021","unstructured":"Pastuszak K et al (2021) imPlatelet classifier: image-converted RNA biomarker profiles enable blood-based cancer diagnostics. Mol Oncol 15(10):2688\u20132701","journal-title":"Mol Oncol"},{"issue":"6","key":"10424_CR230","first-page":"579","volume":"14","author":"Y Gao","year":"2023","unstructured":"Gao Y et al (2023) Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study. Protein Cell 14(6):579\u2013590","journal-title":"Protein Cell"},{"issue":"2","key":"10424_CR231","doi-asserted-by":"publisher","first-page":"345","DOI":"10.21037\/tlcr-24-29","volume":"13","author":"Z Hu","year":"2024","unstructured":"Hu Z et al (2024) PD-L1 mRNA derived from tumor-educated platelets as a potential immunotherapy biomarker in non-small cell lung cancer. Transl Lung Cancer Res 13(2):345\u2013354","journal-title":"Transl Lung Cancer Res"},{"issue":"12","key":"10424_CR232","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1002\/2211-5463.12759","volume":"9","author":"B Yao","year":"2019","unstructured":"Yao B et al (2019) Delivery of platelet TPM3 mRNA into breast cancer cells via microvesicles enhances metastasis. FEBS Open Bio 9(12):2159\u20132169","journal-title":"FEBS Open Bio"},{"key":"10424_CR233","first-page":"173401","volume":"2014","author":"CC Wang","year":"2014","unstructured":"Wang CC et al (2014) Circulating endothelial-derived activated microparticle: a useful biomarker for predicting one-year mortality in patients with advanced non-small cell lung cancer. Biomed Res Int 2014:173401","journal-title":"Biomed Res Int"},{"key":"10424_CR234","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12943-015-0327-z","volume":"14","author":"H Liang","year":"2015","unstructured":"Liang H et al (2015) MicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3. Mol Cancer 14:58","journal-title":"Mol Cancer"},{"issue":"57","key":"10424_CR235","doi-asserted-by":"publisher","first-page":"97464","DOI":"10.18632\/oncotarget.22136","volume":"8","author":"M Tang","year":"2017","unstructured":"Tang M et al (2017) Platelet microparticle-mediated transfer of miR-939 to epithelial ovarian cancer cells promotes epithelial to mesenchymal transition. Oncotarget 8(57):97464\u201397475","journal-title":"Oncotarget"},{"issue":"8","key":"10424_CR236","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1016\/j.bbadis.2018.04.013","volume":"1864","author":"C Anene","year":"2018","unstructured":"Anene C et al (2018) Platelet microparticle delivered microRNA-Let-7a promotes the angiogenic switch. Biochim Biophys Acta Mol Basis Dis 1864(8):2633\u20132643","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"13","key":"10424_CR237","doi-asserted-by":"publisher","first-page":"6445","DOI":"10.7150\/thno.53637","volume":"11","author":"C Zhang","year":"2021","unstructured":"Zhang C et al (2021) Phosphatidylserine-exposing tumor-derived microparticles exacerbate coagulation and cancer cell transendothelial migration in triple-negative breast cancer. Theranostics 11(13):6445\u20136460","journal-title":"Theranostics"},{"issue":"9","key":"10424_CR238","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/j.tranon.2019.05.015","volume":"12","author":"X Meng","year":"2019","unstructured":"Meng X et al (2019) Circulating Mitochondrial DNA is Linked to Progression and Prognosis of Epithelial Ovarian Cancer. Transl Oncol 12(9):1213\u20131220","journal-title":"Transl Oncol"},{"issue":"1","key":"10424_CR239","doi-asserted-by":"publisher","first-page":"5220","DOI":"10.1038\/s41598-019-41593-4","volume":"9","author":"R Meddeb","year":"2019","unstructured":"Meddeb R et al (2019) Quantifying circulating cell-free DNA in humans. Sci Rep 9(1):5220","journal-title":"Sci Rep"},{"issue":"3","key":"10424_CR240","doi-asserted-by":"publisher","first-page":"3616","DOI":"10.1096\/fj.201901917RR","volume":"34","author":"A Al","year":"2020","unstructured":"Al A, Dache Z et al (2020) Blood contains circulating cell-free respiratory competent mitochondria. Faseb j 34(3):3616\u20133630","journal-title":"Faseb j"},{"key":"10424_CR241","doi-asserted-by":"crossref","unstructured":"Arance E et al (2021) Determination of exosome mitochondrial DNA as a biomarker of renal cancer aggressiveness. Cancers (Basel) 14(1)","DOI":"10.3390\/cancers14010199"},{"issue":"1","key":"10424_CR242","doi-asserted-by":"publisher","first-page":"18455","DOI":"10.1038\/s41598-022-22006-5","volume":"12","author":"KS Vikramdeo","year":"2022","unstructured":"Vikramdeo KS et al (2022) Detection of mitochondrial DNA mutations in circulating mitochondria-originated extracellular vesicles for potential diagnostic applications in pancreatic adenocarcinoma. Sci Rep 12(1):18455","journal-title":"Sci Rep"},{"issue":"6","key":"10424_CR243","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1042\/CS20140101","volume":"127","author":"BK Chacko","year":"2014","unstructured":"Chacko BK et al (2014) The bioenergetic health index: a new concept in mitochondrial translational research. Clin Sci (Lond) 127(6):367\u2013373","journal-title":"Clin Sci (Lond)"},{"issue":"21","key":"10424_CR244","doi-asserted-by":"publisher","first-page":"5506","DOI":"10.1158\/0008-5472.CAN-21-1180","volume":"81","author":"B Wu","year":"2021","unstructured":"Wu B et al (2021) Megakaryocytes mediate hyperglycemia-induced tumor metastasis. Cancer Res 81(21):5506\u20135522","journal-title":"Cancer Res"},{"key":"10424_CR245","doi-asserted-by":"crossref","unstructured":"Giannakeas V et al (2022) Platelet count and survival after cancer. Cancers (Basel) 14(3)","DOI":"10.3390\/cancers14030549"},{"key":"10424_CR246","doi-asserted-by":"publisher","first-page":"9699499","DOI":"10.1155\/2021\/9699499","volume":"2021","author":"J Wang","year":"2021","unstructured":"Wang J et al (2021) The ratio of platelets to lymphocytes predicts the prognosis of metastatic colorectal cancer: a review and meta-analysis. Gastroenterol Res Pract 2021:9699499","journal-title":"Gastroenterol Res Pract"},{"key":"10424_CR247","doi-asserted-by":"crossref","unstructured":"Sylman JL et al (2017) Platelet count as a predictor of metastasis and venous thromboembolism in patients with cancer. Converg Sci Phys Oncol 3(2)","DOI":"10.1088\/2057-1739\/aa6c05"},{"key":"10424_CR248","doi-asserted-by":"crossref","unstructured":"Hayes B et al (2021) Circulating tumour cell numbers correlate with platelet count and circulating lymphocyte subsets in men with advanced prostate cancer: data from the ExPeCT clinical trial (CTRIAL-IE 15\u201321). Cancers (Basel) 13(18)","DOI":"10.3390\/cancers13184690"},{"issue":"1","key":"10424_CR249","doi-asserted-by":"publisher","first-page":"15477","DOI":"10.1038\/s41598-021-94735-y","volume":"11","author":"S Anvari","year":"2021","unstructured":"Anvari S, Osei E, Maftoon N (2021) Interactions of platelets with circulating tumor cells contribute to cancer metastasis. Sci Rep 11(1):15477","journal-title":"Sci Rep"},{"issue":"3","key":"10424_CR250","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.eururo.2008.06.038","volume":"56","author":"D Helley","year":"2009","unstructured":"Helley D et al (2009) Platelet microparticles: a potential predictive factor of survival in hormone-refractory prostate cancer patients treated with docetaxel-based chemotherapy. Eur Urol 56(3):479\u2013484","journal-title":"Eur Urol"},{"issue":"3","key":"10424_CR251","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/pcmedi\/pbz014","volume":"2","author":"Q An","year":"2019","unstructured":"An Q et al (2019) The size of cell-free mitochondrial DNA in blood is inversely correlated with tumor burden in cancer patients. Precis Clin Med 2(3):131\u2013139","journal-title":"Precis Clin Med"},{"issue":"5","key":"10424_CR252","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1182\/bloodadvances.2024014008","volume":"9","author":"MA Jopek","year":"2025","unstructured":"Jopek MA et al (2025) Impact of clinical factors on accuracy of ovarian cancer detection via platelet RNA profiling. Blood Adv 9(5):979\u2013989","journal-title":"Blood Adv"},{"key":"10424_CR253","doi-asserted-by":"publisher","first-page":"1303335","DOI":"10.3389\/fonc.2024.1303335","volume":"14","author":"X Wang","year":"2024","unstructured":"Wang X et al (2024) Research progress of CTC, ctDNA, and EVs in cancer liquid biopsy. Front Oncol 14:1303335","journal-title":"Front Oncol"},{"issue":"1","key":"10424_CR254","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/s41392-024-02021-w","volume":"9","author":"L Ma","year":"2024","unstructured":"Ma L et al (2024) Liquid biopsy in cancer current: status, challenges and future prospects. Signal Transduct Target Ther 9(1):336","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"10424_CR255","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1002\/1878-0261.12859","volume":"15","author":"M Antunes-Ferreira","year":"2021","unstructured":"Antunes-Ferreira M, Koppers-Lalic D, W\u00fcrdinger T (2021) Circulating platelets as liquid biopsy sources for cancer detection. Mol Oncol 15(6):1727\u20131743","journal-title":"Mol Oncol"},{"issue":"1","key":"10424_CR256","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41416-023-02506-5","volume":"130","author":"P Elwood","year":"2024","unstructured":"Elwood P et al (2024) Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against. Br J Cancer 130(1):3\u20138","journal-title":"Br J Cancer"},{"issue":"20","key":"10424_CR257","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1001\/jama.2024.4840","volume":"331","author":"WY Chen","year":"2024","unstructured":"Chen WY et al (2024) Aspirin vs placebo as adjuvant therapy for breast cancer: the alliance A011502 randomized trial. JAMA 331(20):1714\u20131721","journal-title":"JAMA"},{"issue":"11","key":"10424_CR258","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1056\/NEJMoa2504650","volume":"393","author":"A Martling","year":"2025","unstructured":"Martling A et al (2025) Low-dose aspirin for PI3K-altered localized colorectal cancer. N Engl J Med 393(11):1051\u20131064","journal-title":"N Engl J Med"},{"key":"10424_CR259","doi-asserted-by":"publisher","first-page":"113927","DOI":"10.1016\/j.biopha.2022.113927","volume":"157","author":"JL Hu","year":"2023","unstructured":"Hu JL, Zhang WJ (2023) The role and pharmacological properties of P2Y12 receptor in cancer and cancer pain. Biomed Pharmacother 157:113927","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10424_CR260","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/ijc.28947","volume":"136","author":"S Gebremeskel","year":"2015","unstructured":"Gebremeskel S et al (2015) The reversible P2Y12 inhibitor ticagrelor inhibits metastasis and improves survival in mouse models of cancer. Int J Cancer 136(1):234\u2013240","journal-title":"Int J Cancer"},{"issue":"2","key":"10424_CR261","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jaccao.2020.04.009","volume":"2","author":"JR Wright","year":"2020","unstructured":"Wright JR et al (2020) The TICONC (Ticagrelor-Oncology) study: implications of P2Y(12) inhibition for metastasis and cancer-associated thrombosis. JACC CardioOncol 2(2):236\u2013250","journal-title":"JACC CardioOncol"},{"key":"10424_CR262","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2026.10047","author":"Jalal Naghinezhad","year":"2026","unstructured":"Naghinezhad J, Mohajerian A, Ahadi S, Khodakarim N, Hamblin MR, Rezaeeyan H. When GPVI Goes Rogue: Pathogenesis and Therapeutic Horizons in ITP. Expert Rev Mol Med. 2026 Apr 13;28:e20. 10.1017\/erm.2026.10047. PMID: 41972260; PMCID: PMC13215716 https:\/\/doi.org\/10.1017\/erm.2026.10047","journal-title":"Expert Rev Mol Med"},{"issue":"14","key":"10424_CR263","doi-asserted-by":"publisher","first-page":"e34361","DOI":"10.1016\/j.heliyon.2024.e34361","volume":"10","author":"H Raskov","year":"2024","unstructured":"Raskov H et al (2024) The impact of platelets on the metastatic potential of tumour cells. Heliyon 10(14):e34361","journal-title":"Heliyon"},{"issue":"1","key":"10424_CR264","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s12935-025-03877-w","volume":"25","author":"J Gan","year":"2025","unstructured":"Gan J, Zhang X, Guo J (2025) The role of platelets in tumor immune evasion and metastasis: mechanisms and therapeutic implications. Cancer Cell Int 25(1):258","journal-title":"Cancer Cell Int"},{"key":"10424_CR265","doi-asserted-by":"publisher","first-page":"1256129","DOI":"10.3389\/fimmu.2023.1256129","volume":"14","author":"J Zhao","year":"2023","unstructured":"Zhao J et al (2023) Decoding the role of platelets in tumour metastasis: enigmatic accomplices and intricate targets for anticancer treatments. Front Immunol 14:1256129","journal-title":"Front Immunol"},{"key":"10424_CR266","doi-asserted-by":"publisher","first-page":"106301","DOI":"10.1016\/j.phrs.2022.106301","volume":"182","author":"B Tesfamariam","year":"2022","unstructured":"Tesfamariam B, Wood SC (2022) Targeting glycoprotein VI to disrupt platelet-mediated tumor cell extravasation. Pharmacol Res 182:106301","journal-title":"Pharmacol Res"},{"key":"10424_CR267","doi-asserted-by":"crossref","unstructured":"Saha B et al (2021) Human tumor microenvironment chip evaluates the consequences of platelet extravasation and combinatorial antitumor-antiplatelet therapy in ovarian cancer. Sci Adv, 7(30)","DOI":"10.1126\/sciadv.abg5283"},{"issue":"1","key":"10424_CR268","first-page":"12","volume":"3","author":"A Contursi","year":"2022","unstructured":"Contursi A et al (2022) The novel antiplatelet agent revacept in cardiovascular medicine: the promise of efficacy without bleeding. J Clin Cardiol 3(1):12\u201320","journal-title":"J Clin Cardiol"},{"issue":"22","key":"10424_CR269","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1182\/blood.2019001388","volume":"134","author":"K Suzuki-Inoue","year":"2019","unstructured":"Suzuki-Inoue K (2019) Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin. Blood 134(22):1912\u20131918","journal-title":"Blood"},{"issue":"1","key":"10424_CR270","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s13045-018-0659-4","volume":"11","author":"Y Qi","year":"2018","unstructured":"Qi Y et al (2018) Novel antibodies against GPIb\u03b1 inhibit pulmonary metastasis by affecting vWF-GPIb\u03b1 interaction. J Hematol Oncol 11(1):117","journal-title":"J Hematol Oncol"},{"issue":"2","key":"10424_CR271","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/jid.2009.278","volume":"130","author":"L Erpenbeck","year":"2010","unstructured":"Erpenbeck L et al (2010) Inhibition of platelet GPIb alpha and promotion of melanoma metastasis. J Invest Dermatol 130(2):576\u2013586","journal-title":"J Invest Dermatol"},{"key":"10424_CR272","doi-asserted-by":"crossref","unstructured":"Covic L, Kuliopulos A (2018) Protease-activated receptor 1 as therapeutic target in breast, lung, and ovarian cancer: pepducin approach. Int J Mol Sci 19(8)","DOI":"10.3390\/ijms19082237"},{"key":"10424_CR273","doi-asserted-by":"crossref","unstructured":"Jia Y et al (2015) Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620 Corrigendum. 33(6):2681\u20132688 Oncology reports. in\/or\/35\/2\/1222","DOI":"10.3892\/or.2015.3897"},{"key":"10424_CR274","doi-asserted-by":"publisher","first-page":"834472","DOI":"10.3389\/fphar.2022.834472","volume":"13","author":"M Smeda","year":"2022","unstructured":"Smeda M et al (2022) Direct thrombin inhibitor dabigatran compromises pulmonary endothelial integrity in a murine model of breast cancer metastasis to the lungs; the role of platelets and inflammation-associated haemostasis. Front Pharmacol 13:834472","journal-title":"Front Pharmacol"},{"issue":"6","key":"10424_CR275","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1111\/jth.14443","volume":"17","author":"JT Buijs","year":"2019","unstructured":"Buijs JT et al (2019) The direct oral anticoagulants rivaroxaban and dabigatran do not inhibit orthotopic growth and metastasis of human breast cancer in mice. J Thromb Haemost 17(6):951\u2013963","journal-title":"J Thromb Haemost"},{"issue":"6","key":"10424_CR276","doi-asserted-by":"publisher","first-page":"3352","DOI":"10.1073\/pnas.061615598","volume":"98","author":"L Borsig","year":"2001","unstructured":"Borsig L et al (2001) Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis. Proc Natl Acad Sci U S A 98(6):3352\u20133357","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10424_CR277","doi-asserted-by":"publisher","first-page":"S107","DOI":"10.1016\/S0049-3848(07)70138-X","volume":"120","author":"JL Stevenson","year":"2007","unstructured":"Stevenson JL, Varki A, Borsig L (2007) Heparin attenuates metastasis mainly due to inhibition of P-and L-selectin, but non-anticoagulant heparins can have additional effects. Thromb Res 120:S107\u2013S111","journal-title":"Thromb Res"},{"key":"10424_CR278","first-page":"16","volume":"19","author":"L Borsig","year":"2004","unstructured":"Borsig L (2004) Selectins facilitate carcinoma metastasis and heparin can prevent them. News Physiol Sci 19:16\u201321","journal-title":"News Physiol Sci"},{"issue":"3","key":"10424_CR279","doi-asserted-by":"publisher","first-page":"100015","DOI":"10.1016\/j.bvth.2024.100015","volume":"1","author":"S Escopy","year":"2024","unstructured":"Escopy S, Chaikof EL (2024) Targeting the P-selectin\/PSGL-1 pathway: discovery of disease-modifying therapeutics for disorders of thromboinflammation. Blood Vessel Thromb Hemost 1(3):100015","journal-title":"Blood Vessel Thromb Hemost"},{"key":"10424_CR280","doi-asserted-by":"crossref","unstructured":"Papa AL et al (2019) Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models. Sci Transl Med, 11(479)","DOI":"10.1126\/scitranslmed.aau5898"},{"issue":"26","key":"10424_CR281","doi-asserted-by":"publisher","first-page":"e2304374","DOI":"10.1002\/adhm.202304374","volume":"13","author":"B Schnoor","year":"2024","unstructured":"Schnoor B et al (2024) Fibrinolytic platelet decoys reduce cancer metastasis by dissociating circulating tumor cell clusters. Adv Healthc Mater 13(26):e2304374","journal-title":"Adv Healthc Mater"},{"key":"10424_CR282","doi-asserted-by":"publisher","first-page":"1625814","DOI":"10.3389\/fimmu.2025.1625814","volume":"16","author":"R Liu","year":"2025","unstructured":"Liu R et al (2025) Unveiling mitochondrial transfer in tumor immune evasion: mechanisms, challenges, and clinical implications. Front Immunol 16:1625814","journal-title":"Front Immunol"},{"issue":"5","key":"10424_CR283","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.7150\/thno.47996","volume":"11","author":"C Tu","year":"2021","unstructured":"Tu C et al (2021) Endocytic pathway inhibition attenuates extracellular vesicle-induced reduction of chemosensitivity to bortezomib in multiple myeloma cells. Theranostics 11(5):2364\u20132380","journal-title":"Theranostics"},{"issue":"9","key":"10424_CR284","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1158\/0008-5472.CAN-18-0773","volume":"79","author":"CR Marlein","year":"2019","unstructured":"Marlein CR et al (2019) CD38-driven mitochondrial trafficking promotes bioenergetic plasticity in multiple myeloma. Cancer Res 79(9):2285\u20132297","journal-title":"Cancer Res"},{"key":"10424_CR285","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1182\/blood-2017-03-772939","volume":"130","author":"C Marlein","year":"2017","unstructured":"Marlein C et al (2017) Mitochondria are transferred from non-malignant stroma cells to malignant plasma cells, via tunnelling nanotubules in a CD38 dependent mechanism, a process that promotes myeloma proliferation. Blood 130:589","journal-title":"Blood"},{"key":"10424_CR286","doi-asserted-by":"publisher","first-page":"215582","DOI":"10.1016\/j.canlet.2022.215582","volume":"532","author":"R You","year":"2022","unstructured":"You R et al (2022) Metformin sensitizes AML cells to chemotherapy through blocking mitochondrial transfer from stromal cells to AML cells. Cancer Lett 532:215582","journal-title":"Cancer Lett"},{"issue":"1","key":"10424_CR287","doi-asserted-by":"publisher","first-page":"115154","DOI":"10.1016\/j.celrep.2024.115154","volume":"44","author":"J Novak","year":"2025","unstructured":"Novak J et al (2025) The adaptor protein Miro1 modulates horizontal transfer of mitochondria in mouse melanoma models. Cell Rep 44(1):115154","journal-title":"Cell Rep"},{"issue":"15","key":"10424_CR288","doi-asserted-by":"publisher","first-page":"5762","DOI":"10.7150\/thno.96508","volume":"14","author":"J Yuan","year":"2024","unstructured":"Yuan J et al (2024) ROCK inhibitor enhances mitochondrial transfer via tunneling nanotubes in retinal pigment epithelium. Theranostics 14(15):5762\u20135777","journal-title":"Theranostics"},{"key":"10424_CR289","doi-asserted-by":"publisher","first-page":"937753","DOI":"10.3389\/fcell.2022.937753","volume":"10","author":"Z Nahacka","year":"2022","unstructured":"Nahacka Z et al (2022) Miro proteins and their role in mitochondrial transfer in cancer and beyond. Front Cell Dev Biol 10:937753","journal-title":"Front Cell Dev Biol"},{"key":"10424_CR290","doi-asserted-by":"crossref","unstructured":"Carles-Fontana R et al (2022) Extracellular vesicle-mediated mitochondrial reprogramming in cancer. Cancers (Basel) 14(8)","DOI":"10.3390\/cancers14081865"},{"issue":"8","key":"10424_CR291","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1111\/jcmm.12316","volume":"18","author":"T Kitani","year":"2014","unstructured":"Kitani T et al (2014) Internalization of isolated functional mitochondria: involvement of macropinocytosis. J Cell Mol Med 18(8):1694\u20131703","journal-title":"J Cell Mol Med"},{"issue":"1","key":"10424_CR292","doi-asserted-by":"publisher","first-page":"12886","DOI":"10.1038\/s41598-017-13227-0","volume":"7","author":"D Patel","year":"2017","unstructured":"Patel D et al (2017) Macropinocytic entry of isolated mitochondria in epidermal growth factor-activated human osteosarcoma cells. Sci Rep 7(1):12886","journal-title":"Sci Rep"},{"issue":"1","key":"10424_CR293","doi-asserted-by":"publisher","first-page":"44799","DOI":"10.1038\/s41598-025-28494-5","volume":"15","author":"M Kanai","year":"2025","unstructured":"Kanai M et al (2025) Uptake mechanisms and functions of isolated mitochondria in mesenchymal stromal cells. Sci Rep 15(1):44799","journal-title":"Sci Rep"},{"issue":"5","key":"10424_CR294","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1111\/febs.13946","volume":"284","author":"E Lou","year":"2017","unstructured":"Lou E et al (2017) Lost in translation: applying 2D intercellular communication via tunneling nanotubes in cell culture to physiologically relevant 3D microenvironments. Febs j 284(5):699\u2013707","journal-title":"Febs j"},{"issue":"5","key":"10424_CR295","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1242\/bio.201511478","volume":"4","author":"CA Pacak","year":"2015","unstructured":"Pacak CA et al (2015) Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function. Biol Open 4(5):622\u2013626","journal-title":"Biol Open"},{"issue":"5","key":"10424_CR296","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1681\/ASN.2020071076","volume":"32","author":"F Barutta","year":"2021","unstructured":"Barutta F et al (2021) Protective role of the M-sec-tunneling nanotube system in podocytes. J Am Soc Nephrol 32(5):1114\u20131130","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"10424_CR297","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1080\/15548627.2022.2080382","volume":"19","author":"F Barutta","year":"2023","unstructured":"Barutta F et al (2023) Protective effect of the tunneling nanotube-TNFAIP2\/M-sec system on podocyte autophagy in diabetic nephropathy. Autophagy 19(2):505\u2013524","journal-title":"Autophagy"},{"issue":"5","key":"10424_CR298","doi-asserted-by":"publisher","first-page":"C877","DOI":"10.1152\/ajpcell.00351.2020","volume":"319","author":"S Zhang","year":"2020","unstructured":"Zhang S, Kazanietz MG, Cooke M (2020) Rho GTPases and the emerging role of tunneling nanotubes in physiology and disease. Am J Physiol Cell Physiol 319(5):C877\u2013c884","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"10424_CR299","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1177\/0271678X20928147","volume":"41","author":"N Tseng","year":"2021","unstructured":"Tseng N et al (2021) Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1. J Cereb Blood Flow Metab 41(4):761\u2013770","journal-title":"J Cereb Blood Flow Metab"},{"key":"10424_CR300","doi-asserted-by":"crossref","unstructured":"Yang J et al (2023) Extracellular vesicles and Cx43-gap junction channels are the main routes for mitochondrial transfer from ultra-purified mesenchymal stem cells, RECs. Int J Mol Sci 24(12)","DOI":"10.3390\/ijms241210294"},{"issue":"13","key":"10424_CR301","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1167\/iovs.65.13.10","volume":"65","author":"S Pal-Ghosh","year":"2024","unstructured":"Pal-Ghosh S et al (2024) Mechanisms regulating mitochondrial transfer in human corneal epithelial cells. Invest Ophthalmol Vis Sci 65(13):10","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10424_CR302","doi-asserted-by":"crossref","unstructured":"Irwin RM et al (2024) Connexin 43 regulates intercellular mitochondrial transfer from human mesenchymal stromal cells to chondrocytes. bioRxiv","DOI":"10.1101\/2024.03.18.585552"},{"key":"10424_CR303","doi-asserted-by":"crossref","unstructured":"Kami D, Gojo S (2020) From cell entry to engraftment of exogenous mitochondria. Int J Mol Sci 21(14)","DOI":"10.3390\/ijms21144995"},{"issue":"8","key":"10424_CR304","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1631\/jzus.B2300566","volume":"25","author":"H Xiang","year":"2024","unstructured":"Xiang H et al (2024) Extracellular vesicles (EVs)\u2019 journey in recipient cells: from recognition to cargo release. J Zhejiang Univ Sci B 25(8):633\u2013655","journal-title":"J Zhejiang Univ Sci B"},{"issue":"7","key":"10424_CR305","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1002\/1878-0261.13583","volume":"18","author":"M Pujalte-Martin","year":"2024","unstructured":"Pujalte-Martin M et al (2024) Targeting cancer and immune cell metabolism with the complex I inhibitors metformin and IACS-010759. Mol Oncol 18(7):1719\u20131738","journal-title":"Mol Oncol"},{"issue":"1","key":"10424_CR306","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/ijc.32616","volume":"146","author":"V Sica","year":"2020","unstructured":"Sica V et al (2020) Oxidative phosphorylation as a potential therapeutic target for cancer therapy. Int J Cancer 146(1):10\u201317","journal-title":"Int J Cancer"},{"issue":"23","key":"10424_CR307","doi-asserted-by":"publisher","first-page":"34084","DOI":"10.18632\/oncotarget.9122","volume":"7","author":"M Fiorillo","year":"2016","unstructured":"Fiorillo M et al (2016) Repurposing atovaquone: targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells. Oncotarget 7(23):34084\u201334099","journal-title":"Oncotarget"},{"key":"10424_CR308","doi-asserted-by":"crossref","unstructured":"Capeloa T et al (2022) Inhibition of mitochondrial redox signaling with MitoQ prevents metastasis of human pancreatic cancer in mice. Cancers (Basel) 14(19)","DOI":"10.3390\/cancers14194918"},{"issue":"9","key":"10424_CR309","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1158\/0008-5472.CAN-20-1628","volume":"81","author":"C Sandoval-Acu\u00f1a","year":"2021","unstructured":"Sandoval-Acu\u00f1a C et al (2021) Targeting mitochondrial iron metabolism suppresses tumor growth and metastasis by inducing mitochondrial dysfunction and mitophagy. Cancer Res 81(9):2289\u20132303","journal-title":"Cancer Res"},{"key":"10424_CR310","doi-asserted-by":"crossref","unstructured":"Monroy-C\u00e1rdenas M et al (2023) A new quinone-based inhibitor of mitochondrial complex I in D-conformation, producing invasion reduction and sensitization to venetoclax in breast cancer cells. Antioxid (Basel) 12(8)","DOI":"10.3390\/antiox12081597"},{"issue":"7919","key":"10424_CR311","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/s41586-022-04898-5","volume":"607","author":"S Delaunay","year":"2022","unstructured":"Delaunay S et al (2022) Mitochondrial RNA modifications shape metabolic plasticity in metastasis. Nature 607(7919):593\u2013603","journal-title":"Nature"},{"issue":"1","key":"10424_CR312","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13046-023-02931-7","volume":"43","author":"S Alcal\u00e1","year":"2024","unstructured":"Alcal\u00e1 S et al (2024) Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy. J Exp Clin Cancer Res 43(1):33","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"10424_CR313","doi-asserted-by":"publisher","first-page":"5265","DOI":"10.1038\/s41467-020-18954-z","volume":"11","author":"S Valle","year":"2020","unstructured":"Valle S et al (2020) Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells. Nat Commun 11(1):5265","journal-title":"Nat Commun"},{"issue":"5","key":"10424_CR314","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s13402-021-00623-y","volume":"44","author":"M van der Merwe","year":"2021","unstructured":"van der Merwe M et al (2021) The impact of mitochondria on cancer treatment resistance. Cell Oncol (Dordr) 44(5):983\u2013995","journal-title":"Cell Oncol (Dordr)"},{"issue":"5","key":"10424_CR315","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1177\/1535370220909309","volume":"245","author":"YA Shen","year":"2020","unstructured":"Shen YA et al (2020) Targeting cancer stem cells from a metabolic perspective. Exp Biol Med (Maywood) 245(5):465\u2013476","journal-title":"Exp Biol Med (Maywood)"},{"issue":"25","key":"10424_CR316","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1182\/blood.2018877043","volume":"133","author":"J Volz","year":"2019","unstructured":"Volz J et al (2019) Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice. Blood 133(25):2696\u20132706","journal-title":"Blood"},{"issue":"1","key":"10424_CR317","doi-asserted-by":"publisher","first-page":"1957605","DOI":"10.1080\/2162402X.2021.1957605","volume":"10","author":"Y Zhang","year":"2021","unstructured":"Zhang Y et al (2021) The effect of concomitant use of statins, NSAIDs, low-dose aspirin, metformin and beta-blockers on outcomes in patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis. Oncoimmunology 10(1):1957605","journal-title":"Oncoimmunology"},{"key":"10424_CR318","doi-asserted-by":"publisher","first-page":"1259628","DOI":"10.3389\/fphar.2023.1259628","volume":"14","author":"H Yang","year":"2023","unstructured":"Yang H et al (2023) The association between aspirin use and immune-related adverse events in specific cancer patients receiving ICIs therapy: analysis of the FAERS database. Front Pharmacol 14:1259628","journal-title":"Front Pharmacol"},{"issue":"1","key":"10424_CR319","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s40164-025-00676-x","volume":"14","author":"C Cai","year":"2025","unstructured":"Cai C et al (2025) Platelets in cancer and immunotherapy: functional dynamics and therapeutic opportunities. Exp Hematol Oncol 14(1):83","journal-title":"Exp Hematol Oncol"},{"issue":"1","key":"10424_CR320","doi-asserted-by":"publisher","first-page":"oeaf163","DOI":"10.1093\/ehjopen\/oeaf163","volume":"6","author":"R Ohiomoba","year":"2026","unstructured":"Ohiomoba R et al (2026) Relationship of cancer and dual antiplatelet duration to long-term risk of ischaemic and bleeding outcomes after percutaneous coronary intervention. Eur Heart J Open 6(1):oeaf163","journal-title":"Eur Heart J Open"},{"issue":"10","key":"10424_CR321","doi-asserted-by":"publisher","first-page":"104473","DOI":"10.1016\/j.drudis.2025.104473","volume":"30","author":"R Li","year":"2025","unstructured":"Li R et al (2025) Blocking platelet glycoprotein VI (GPVI) as a promising antithrombotic treatment. Drug Discov Today 30(10):104473","journal-title":"Drug Discov Today"},{"issue":"8","key":"10424_CR322","doi-asserted-by":"publisher","first-page":"e750","DOI":"10.1097\/HS9.0000000000000750","volume":"6","author":"A Falanga","year":"2022","unstructured":"Falanga A et al (2022) EHA guidelines on management of antithrombotic treatments in thrombocytopenic patients with cancer. Hemasphere 6(8):e750","journal-title":"Hemasphere"},{"key":"10424_CR323","doi-asserted-by":"publisher","first-page":"101848","DOI":"10.1016\/j.mito.2024.101848","volume":"75","author":"A Caicedo","year":"2024","unstructured":"Caicedo A et al (2024) Decoding the nature and complexity of extracellular mtDNA: Types and implications for health and disease. Mitochondrion 75:101848","journal-title":"Mitochondrion"},{"key":"10424_CR324","doi-asserted-by":"publisher","first-page":"1640748","DOI":"10.3389\/fimmu.2025.1640748","volume":"16","author":"Y Zhao","year":"2025","unstructured":"Zhao Y et al (2025) Cell-free mitochondrial DNA as a pro-inflammatory agent in blood circulation: mechanisms, therapeutic implications, and clinical challenges in immune dysregulation. Front Immunol 16:1640748","journal-title":"Front Immunol"},{"issue":"29","key":"10424_CR325","doi-asserted-by":"publisher","first-page":"eadt1318","DOI":"10.1126\/sciadv.adt1318","volume":"11","author":"P Lou","year":"2025","unstructured":"Lou P et al (2025) Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine. Sci Adv 11(29):eadt1318","journal-title":"Sci Adv"},{"key":"10424_CR326","doi-asserted-by":"publisher","first-page":"1774015","DOI":"10.3389\/fmolb.2026.1774015","volume":"13","author":"Y Liu","year":"2026","unstructured":"Liu Y et al (2026) Cell-free mitochondrial DNA (cf-mtDNA) in human body fluids: molecular characteristics, release mechanisms, and clinical translation-an updated review. Front Mol Biosci 13:1774015","journal-title":"Front Mol Biosci"},{"issue":"8","key":"10424_CR327","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1016\/j.jtha.2023.04.042","volume":"21","author":"BA Bettin","year":"2023","unstructured":"Bettin BA et al (2023) Standardization of extracellular vesicle concentration measurements by flow cytometry: the past, present, and future. J Thromb Haemost 21(8):2032\u20132044","journal-title":"J Thromb Haemost"},{"key":"10424_CR328","doi-asserted-by":"publisher","first-page":"102842","DOI":"10.1016\/j.bcmd.2024.102842","volume":"106","author":"I Mari\u0107","year":"2024","unstructured":"Mari\u0107 I et al (2024) Platelet activation and blood extracellular vesicles: the influence of venepuncture and short blood storage. Blood Cells Mol Dis 106:102842","journal-title":"Blood Cells Mol Dis"},{"issue":"1","key":"10424_CR329","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/j.1538-7836.2008.03200.x","volume":"7","author":"S Robert","year":"2009","unstructured":"Robert S et al (2009) Standardization of platelet-derived microparticle counting using calibrated beads and a Cytomics FC500 routine flow cytometer: a first step towards multicenter studies? J Thromb Haemost 7(1):190\u2013197","journal-title":"J Thromb Haemost"},{"issue":"1","key":"10424_CR330","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/jth.13514","volume":"15","author":"S Cointe","year":"2017","unstructured":"Cointe S et al (2017) Standardization of microparticle enumeration across different flow cytometry platforms: results of a multicenter collaborative workshop. J Thromb Haemost 15(1):187\u2013193","journal-title":"J Thromb Haemost"},{"issue":"3","key":"10424_CR331","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/vox.70172","volume":"121","author":"Y Chintala","year":"2026","unstructured":"Chintala Y et al (2026) From platelets to particles: optimizing extracellular vesicle isolation in a National Blood Centre. Vox Sang 121(3):245\u2013253","journal-title":"Vox Sang"},{"issue":"9","key":"10424_CR332","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1111\/febs.70002","volume":"292","author":"JS Bjerring","year":"2025","unstructured":"Bjerring JS et al (2025) Intercellular mitochondrial transfer contributes to microenvironmental redirection of cancer cell fate. Febs j 292(9):2306\u20132322","journal-title":"Febs j"},{"issue":"1","key":"10424_CR333","doi-asserted-by":"publisher","first-page":"8802","DOI":"10.1038\/s41467-024-52867-5","volume":"15","author":"GK Atkin-Smith","year":"2024","unstructured":"Atkin-Smith GK et al (2024) In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions. Nat Commun 15(1):8802","journal-title":"Nat Commun"},{"key":"10424_CR334","doi-asserted-by":"publisher","first-page":"1630658","DOI":"10.3389\/fimmu.2025.1630658","volume":"16","author":"S Li","year":"2025","unstructured":"Li S et al (2025) Visualizing cellular interactions: intravital imaging in tumor microenvironment. Front Immunol 16:1630658","journal-title":"Front Immunol"},{"issue":"10","key":"10424_CR335","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1182\/blood.2023022608","volume":"144","author":"A Ballard-Kordeliski","year":"2024","unstructured":"Ballard-Kordeliski A et al (2024) 4D intravital imaging studies identify platelets as the predominant cellular procoagulant surface in a mouse hemostasis model. Blood 144(10):1116\u20131126","journal-title":"Blood"},{"issue":"1","key":"10424_CR336","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s44342-025-00064-1","volume":"24","author":"HI Ka","year":"2026","unstructured":"Ka HI, Woo HG (2026) Mitochondrial transfer in cancer: mechanisms, immune evasion, and therapeutic opportunities. Genomics Inf 24(1):2","journal-title":"Genomics Inf"},{"issue":"8","key":"10424_CR337","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.7150\/thno.96027","volume":"14","author":"D Xiang","year":"2024","unstructured":"Xiang D et al (2024) Building consensus on the application of organoid-based drug sensitivity testing in cancer precision medicine and drug development. Theranostics 14(8):3300\u20133316","journal-title":"Theranostics"},{"issue":"11","key":"10424_CR338","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.medj.2024.08.010","volume":"5","author":"L Tong","year":"2024","unstructured":"Tong L et al (2024) Patient-derived organoids in precision cancer medicine. Med 5(11):1351\u20131377","journal-title":"Med"},{"key":"10424_CR339","doi-asserted-by":"publisher","first-page":"1670328","DOI":"10.3389\/fcell.2025.1670328","volume":"13","author":"H Singh","year":"2025","unstructured":"Singh H, Mijakovic I, Singh P (2025) Advances in precision oncology using patient-derived organoids and functional biomaterials. Front Cell Dev Biol 13:1670328","journal-title":"Front Cell Dev Biol"},{"issue":"6","key":"10424_CR340","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1111\/jth.14009","volume":"16","author":"E van der Pol","year":"2018","unstructured":"van der Pol E et al (2018) Standardization of extracellular vesicle measurements by flow cytometry through vesicle diameter approximation. J Thromb Haemost 16(6):1236\u20131245","journal-title":"J Thromb Haemost"}],"container-title":["Clinical & Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-026-10424-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10585-026-10424-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-026-10424-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:03:06Z","timestamp":1790193786000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10585-026-10424-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":340,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["10424"],"URL":"https:\/\/doi.org\/10.1007\/s10585-026-10424-y","relation":{},"ISSN":["1573-7276"],"issn-type":[{"value":"1573-7276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]},"assertion":[{"value":"12 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In this article funding statement has been replaced to acknowlegement section and corrected in the original publication.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"43"}}