{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T23:16:54Z","timestamp":1788131814510,"version":"build-2803163510"},"reference-count":94,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Metastasis"],"DOI":"10.1007\/s10585-026-10427-9","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T11:06:11Z","timestamp":1788087971000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CX3CL1\/CX3CR1 signaling in spinal metastasis: mechanisms and translational opportunities"],"prefix":"10.1007","volume":"43","author":[{"given":"Vivek","family":"Sanker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhikai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Urdaneta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaditya","family":"Dravid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Heesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Frantzias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jose","family":"Cavagnaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ratliff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irimpan","family":"Mathews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atman","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"key":"10427_CR1","unstructured":"Ziu E, Viswanathan VK, Mesfin FB (2025). Spinal metastasis. In: StatPearls. StatPearls Publishing. Accessed 14 July 2025. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK441950\/"},{"key":"10427_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbo.2022.100446","volume":"35","author":"R Van den Brande","year":"2022","unstructured":"Van den Brande R, Cornips EM, Peeters M, Ost P, Billiet C, Van de Kelft E (2022) Epidemiology of spinal metastases, metastatic epidural spinal cord compression and pathologic vertebral compression fractures in patients with solid tumors: A systematic review. J Bone Oncol 35:100446. https:\/\/doi.org\/10.1016\/j.jbo.2022.100446","journal-title":"J Bone Oncol"},{"issue":"4","key":"10427_CR3","doi-asserted-by":"publisher","first-page":"978","DOI":"10.14245\/ns.2244290.145","volume":"19","author":"EI Fomchenko","year":"2022","unstructured":"Fomchenko EI, Bayley JC, Alvarez-Breckenridge C, Rhines LD, Tatsui CE (2022) Spinal metastases and the evolving role of molecular targeted therapy, chemotherapy, and immunotherapy. Neurospine 19(4):978\u2013993. https:\/\/doi.org\/10.14245\/ns.2244290.145","journal-title":"Neurospine"},{"issue":"1","key":"10427_CR4","doi-asserted-by":"publisher","first-page":"e38","DOI":"10.3928\/01477447-20171106-06","volume":"41","author":"CS Hibberd","year":"2018","unstructured":"Hibberd CS, Quan GMY (2018) Risk factors for pathological fracture and metastatic epidural spinal cord compression in patients with spinal metastases. Orthopedics 41(1):e38\u2013e45. https:\/\/doi.org\/10.3928\/01477447-20171106-06","journal-title":"Orthopedics"},{"key":"10427_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1374915","volume":"14","author":"T Morimoto","year":"2024","unstructured":"Morimoto T, Toda Y, Hakozaki M et al (2024) A new era in the management of spinal metastasis. Front Oncol 14:1374915. https:\/\/doi.org\/10.3389\/fonc.2024.1374915","journal-title":"Front Oncol"},{"issue":"1","key":"10427_CR6","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1097\/00000658-194007000-00016","volume":"112","author":"OV Batson","year":"1940","unstructured":"Batson OV (1940) The function of the vertebral veins and their role in the spread of metastases. Ann Surg 112(1):138\u2013149. https:\/\/doi.org\/10.1097\/00000658-194007000-00016","journal-title":"Ann Surg"},{"issue":"3\u20134","key":"10427_CR7","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1159\/000225060","volume":"32","author":"WI Onuigbo","year":"1975","unstructured":"Onuigbo WI (1975) Batson\u2019s theory of vertebral venous metastasis: a review. Oncology 32(3\u20134):145\u2013150. https:\/\/doi.org\/10.1159\/000225060","journal-title":"Oncology"},{"issue":"4","key":"10427_CR8","doi-asserted-by":"publisher","first-page":"635","DOI":"10.5137\/1019-5149.JTN.8476-13.0","volume":"26","author":"AL Aydin","year":"2016","unstructured":"Aydin AL, Emel E, Sasani M, Gomleksiz C, Oktenoglu T, Ozer AF (2016) Lung cancer metastasis to the spine. Turk Neurosurg 26(4):635\u2013642. https:\/\/doi.org\/10.5137\/1019-5149.JTN.8476-13.0","journal-title":"Turk Neurosurg"},{"key":"10427_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.115159","volume":"138","author":"S Bailey","year":"2020","unstructured":"Bailey S, Hackney D, Vashishth D, Alkalay RN (2020) The effects of metastatic lesion on the structural determinants of bone: current clinical and experimental approaches. Bone 138:115159. https:\/\/doi.org\/10.1016\/j.bone.2019.115159","journal-title":"Bone"},{"issue":"4","key":"10427_CR10","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s10456-017-9577-2","volume":"20","author":"M Hassanshahi","year":"2017","unstructured":"Hassanshahi M, Hassanshahi A, Khabbazi S, Su YW, Xian CJ (2017) Bone marrow sinusoidal endothelium: damage and potential regeneration following cancer radiotherapy or chemotherapy. Angiogenesis 20(4):427\u2013442. https:\/\/doi.org\/10.1007\/s10456-017-9577-2","journal-title":"Angiogenesis"},{"issue":"3","key":"10427_CR11","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s12307-011-0081-8","volume":"4","author":"SI Park","year":"2011","unstructured":"Park SI, Soki FN, McCauley LK (2011) Roles of bone marrow cells in skeletal metastases: no longer bystanders. Cancer Microenviron 4(3):237\u2013246. https:\/\/doi.org\/10.1007\/s12307-011-0081-8","journal-title":"Cancer Microenviron"},{"issue":"2","key":"10427_CR12","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/BF00176898","volume":"8","author":"S Paget","year":"1989","unstructured":"Paget S (1989) The distribution of secondary growths in cancer of the breast. Cancer Metastasis Rev 8(2):98\u2013101","journal-title":"Cancer Metastasis Rev"},{"issue":"9\u201310","key":"10427_CR13","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1046\/j.1432-0436.2002.700904.x","volume":"70","author":"IJ Fidler","year":"2002","unstructured":"Fidler IJ (2002) The organ microenvironment and cancer metastasis. Differ Res Biol Divers 70(9\u201310):498\u2013505. https:\/\/doi.org\/10.1046\/j.1432-0436.2002.700904.x","journal-title":"Differ Res Biol Divers"},{"issue":"7586","key":"10427_CR14","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature17038","volume":"529","author":"J Massagu\u00e9","year":"2016","unstructured":"Massagu\u00e9 J, Obenauf AC (2016) Metastatic colonization by circulating tumour cells. Nature 529(7586):298\u2013306. https:\/\/doi.org\/10.1038\/nature17038","journal-title":"Nature"},{"issue":"14","key":"10427_CR15","doi-asserted-by":"publisher","first-page":"4693","DOI":"10.1158\/0008-5472.CAN-03-3437","volume":"64","author":"SA Shulby","year":"2004","unstructured":"Shulby SA, Dolloff NG, Stearns ME, Meucci O, Fatatis A (2004) CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration, and survival of human prostate cancer cells. Cancer Res 64(14):4693\u20134698. https:\/\/doi.org\/10.1158\/0008-5472.CAN-03-3437","journal-title":"Cancer Res"},{"issue":"6617","key":"10427_CR16","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/385640a0","volume":"385","author":"JF Bazan","year":"1997","unstructured":"Bazan JF, Bacon KB, Hardiman G et al (1997) A new class of membrane-bound chemokine with a CX3C motif. Nature 385(6617):640\u2013644. https:\/\/doi.org\/10.1038\/385640a0","journal-title":"Nature"},{"issue":"4","key":"10427_CR17","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.3892\/ijo.2018.4487","volume":"53","author":"P Liu","year":"2018","unstructured":"Liu P, Liang Y, Jiang L, Wang H, Wang S, Dong J (2018) CX3CL1\/fractalkine enhances prostate cancer spinal metastasis by activating the Src\/FAK pathway. Int J Oncol 53(4):1544\u20131556. https:\/\/doi.org\/10.3892\/ijo.2018.4487","journal-title":"Int J Oncol"},{"issue":"4","key":"10427_CR18","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2022.5337","volume":"60","author":"Q Meng","year":"2022","unstructured":"Meng Q, Zhou L, Liang H et al (2022) Spine\u2011specific downregulation of LAPTM5 expression promotes the progression and spinal metastasis of estrogen receptor\u2011positive breast cancer by activating glutamine\u2011dependent mTOR signaling. Int J Oncol 60(4):47. https:\/\/doi.org\/10.3892\/ijo.2022.5337","journal-title":"Int J Oncol"},{"issue":"2","key":"10427_CR19","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/s12094-020-02431-6","volume":"23","author":"Y Liu","year":"2021","unstructured":"Liu Y, Ma H, Dong T, Yan Y, Sun L, Wang W (2021) Clinical significance of expression level of CX3CL1-CX3CR1 axis in bone metastasis of lung cancer. Clin Transl Oncol 23(2):378\u2013388. https:\/\/doi.org\/10.1007\/s12094-020-02431-6","journal-title":"Clin Transl Oncol"},{"issue":"1","key":"10427_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8010041","volume":"8","author":"G Siracusano","year":"2020","unstructured":"Siracusano G, Tagliamonte M, Buonaguro L, Lopalco L (2020) Cell surface proteins in hepatocellular carcinoma: from bench to bedside. Vaccines 8(1):41. https:\/\/doi.org\/10.3390\/vaccines8010041","journal-title":"Vaccines"},{"key":"10427_CR21","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/s0065-2776(01)78002-9","volume":"78","author":"O Yoshie","year":"2001","unstructured":"Yoshie O, Imai T, Nomiyama H (2001) Chemokines in immunity. Adv Immunol 78:57\u2013110. https:\/\/doi.org\/10.1016\/s0065-2776(01)78002-9","journal-title":"Adv Immunol"},{"issue":"12","key":"10427_CR22","doi-asserted-by":"publisher","first-page":"7825","DOI":"10.4049\/jimmunol.0803627","volume":"183","author":"K Koizumi","year":"1950","unstructured":"Koizumi K, Saitoh Y, Minami T et al (1950) Role of CX3CL1\/fractalkine in osteoclast differentiation and bone resorption. J Immunol 183(12):7825\u20137831. https:\/\/doi.org\/10.4049\/jimmunol.0803627","journal-title":"J Immunol"},{"issue":"3","key":"10427_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11030321","volume":"11","author":"V Marchica","year":"2019","unstructured":"Marchica V, Toscani D, Corcione A et al (2019) Bone marrow CX3CL1\/fractalkine is a new player of the pro-angiogenic microenvironment in multiple myeloma patients. Cancers 11(3):321. https:\/\/doi.org\/10.3390\/cancers11030321","journal-title":"Cancers"},{"key":"10427_CR24","unstructured":"Tissue expression of CX3CL1\u2014Staining in bone marrow\u2014The Human Protein Atlas. Accessed 16 July 2025. https:\/\/www.proteinatlas.org\/ENSG00000006210-CX3CL1\/tissue\/bone+marrow"},{"issue":"1","key":"10427_CR25","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s10555-007-9109-4","volume":"27","author":"KM Bussard","year":"2008","unstructured":"Bussard KM, Gay CV, Mastro AM (2008) The bone microenvironment in metastasis; what is special about bone? Cancer Metastasis Rev 27(1):41\u201355. https:\/\/doi.org\/10.1007\/s10555-007-9109-4","journal-title":"Cancer Metastasis Rev"},{"issue":"6824","key":"10427_CR26","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/35065016","volume":"410","author":"A M\u00fcller","year":"2001","unstructured":"M\u00fcller A, Homey B, Soto H et al (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410(6824):50\u201356. https:\/\/doi.org\/10.1038\/35065016","journal-title":"Nature"},{"issue":"19","key":"10427_CR27","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.7150\/jca.26497","volume":"9","author":"Y Liang","year":"2018","unstructured":"Liang Y, Yi L, Liu P et al (2018) CX3CL1 involves in breast cancer metastasizing to the spine via the Src\/FAK signaling pathway. J Cancer 9(19):3603\u20133612. https:\/\/doi.org\/10.7150\/jca.26497","journal-title":"J Cancer"},{"key":"10427_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-030-36667-4_1","volume":"1231","author":"MJ Conroy","year":"2020","unstructured":"Conroy MJ, Lysaght J (2020) CX3CL1 Signaling in the Tumor Microenvironment. Adv Exp Med Biol 1231:1\u201312. https:\/\/doi.org\/10.1007\/978-3-030-36667-4_1","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"10427_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3016","volume":"13","author":"WL Jamieson-Gladney","year":"2011","unstructured":"Jamieson-Gladney WL, Zhang Y, Fong AM, Meucci O, Fatatis A (2011) The chemokine receptor CX\u2083CR1 is directly involved in the arrest of breast cancer cells to the skeleton. Breast Cancer Res 13(5):R91. https:\/\/doi.org\/10.1186\/bcr3016","journal-title":"Breast Cancer Res"},{"issue":"6","key":"10427_CR30","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1158\/1541-7786.MCR-16-0013","volume":"14","author":"F Shen","year":"2016","unstructured":"Shen F, Zhang Y, Jernigan DL et al (2016) Novel small-molecule CX3CR1 antagonist impairs metastatic seeding and colonization of breast cancer cells. Mol Cancer Res 14(6):518\u2013527. https:\/\/doi.org\/10.1158\/1541-7786.MCR-16-0013","journal-title":"Mol Cancer Res"},{"issue":"9","key":"10427_CR31","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1038\/s41388-021-02174-w","volume":"41","author":"A DiNatale","year":"2022","unstructured":"DiNatale A, Kaur R, Qian C et al (2022) Subsets of cancer cells expressing CX3CR1 are endowed with metastasis-initiating properties and resistance to chemotherapy. Oncogene 41(9):1337\u20131351. https:\/\/doi.org\/10.1038\/s41388-021-02174-w","journal-title":"Oncogene"},{"issue":"4","key":"10427_CR32","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10529","volume":"22","author":"H Zhang","year":"2021","unstructured":"Zhang H, Li S, Bao J, Ge N, Hong F, Qian L (2021) \u03b2-elemene inhibits non-small cell lung cancer cell migration and invasion by inactivating the FAK-Src pathway. Exp Ther Med 22(4):1095. https:\/\/doi.org\/10.3892\/etm.2021.10529","journal-title":"Exp Ther Med"},{"issue":"9","key":"10427_CR33","doi-asserted-by":"publisher","first-page":"15213","DOI":"10.18632\/oncotarget.14773","volume":"8","author":"W Liu","year":"2017","unstructured":"Liu W, Bian C, Liang Y, Jiang L, Qian C, Dong J (2017) CX3CL1: a potential chemokine widely involved in the process spinal metastases. Oncotarget 8(9):15213\u201315219. https:\/\/doi.org\/10.18632\/oncotarget.14773","journal-title":"Oncotarget"},{"issue":"1","key":"10427_CR34","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-025-01711-1","volume":"25","author":"A Ghorbani Vanan","year":"2025","unstructured":"Ghorbani Vanan A, Nami MT, Ghorbaninezhad F et al (2025) Macrophage polarization in hepatocellular carcinoma: a lncRNA-centric perspective on tumor progression and metastasis. Clin Exp Med 25(1):173. https:\/\/doi.org\/10.1007\/s10238-025-01711-1","journal-title":"Clin Exp Med"},{"issue":"5","key":"10427_CR35","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/imcb.12225","volume":"97","author":"F Ren","year":"2019","unstructured":"Ren F et al (2019) The R132H mutation in IDH 1 promotes the recruitment of NK cells through CX 3 CL 1\/CX 3 CR 1 chemotaxis and is correlated with a better prognosis in gliomas. Immunol Cell Biol 97(5):457\u2013469. https:\/\/doi.org\/10.1111\/imcb.12225","journal-title":"Immunol Cell Biol"},{"issue":"4","key":"10427_CR36","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1002\/jso.23095","volume":"106","author":"MH Park","year":"2012","unstructured":"Park MH, Lee JS, Yoon JH (2012) High expression of CX3CL1 by tumor cells correlates with a good prognosis and increased tumor-infiltrating CD8+ T cells, natural killer cells, and dendritic cells in breast carcinoma. J Surg Oncol 106(4):386\u2013392. https:\/\/doi.org\/10.1002\/jso.23095","journal-title":"J Surg Oncol"},{"issue":"1","key":"10427_CR37","first-page":"41","volume":"26","author":"M Ohta","year":"2005","unstructured":"Ohta M, Tanaka F, Yamaguchi H, Sadanaga N, Inoue H, Mori M (2005) The high expression of Fractalkine results in a better prognosis for colorectal cancer patients. Int J Oncol 26(1):41\u201347","journal-title":"Int J Oncol"},{"issue":"4","key":"10427_CR38","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1620\/tjem.200.187","volume":"200","author":"K Yamashita","year":"2003","unstructured":"Yamashita K et al (2003) Effect of hypoxia on the expression of fractalkine in human endothelial cells. Tohoku J Exp Med 200(4):187\u2013194. https:\/\/doi.org\/10.1620\/tjem.200.187","journal-title":"Tohoku J Exp Med"},{"issue":"4","key":"10427_CR39","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1002\/jlb.67.4.577","volume":"67","author":"GE Garcia","year":"2000","unstructured":"Garcia GE, Xia Y, Chen S et al (2000) NF-\u03baB-dependent fractalkine induction in rat aortic endothelial cells stimulated by IL-1\u03b2, TNF-\u03b1, and LPS. J Leukoc Biol 67(4):577\u2013584. https:\/\/doi.org\/10.1002\/jlb.67.4.577","journal-title":"J Leukoc Biol"},{"issue":"5","key":"10427_CR40","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/S0002-9440(10)63725-X","volume":"164","author":"SY Ahn","year":"2004","unstructured":"Ahn SY, Cho CH, Park KG et al (2004) Tumor necrosis factor-\u03b1 induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-\u03b1-induced fractalkine expression. Am J Pathol 164(5):1663\u20131672. https:\/\/doi.org\/10.1016\/S0002-9440(10)63725-X","journal-title":"Am J Pathol"},{"issue":"8","key":"10427_CR41","doi-asserted-by":"publisher","first-page":"4205","DOI":"10.4049\/jimmunol.0903212","volume":"184","author":"T Matsumiya","year":"2010","unstructured":"Matsumiya T, Ota K, Imaizumi T, Yoshida H, Kimura H, Satoh K (2010) Characterization of synergistic induction of CX3CL1\/fractalkine by TNF-\u03b1 and IFN-\u03b3 in vascular endothelial cells: an essential role for TNF-\u03b1 in post-transcriptional regulation of CX3CL1. J Immunol 184(8):4205\u20134214. https:\/\/doi.org\/10.4049\/jimmunol.0903212","journal-title":"J Immunol"},{"issue":"14","key":"10427_CR42","first-page":"3722","volume":"60","author":"K Shiraishi","year":"2000","unstructured":"Shiraishi K, Fukuda S, Mori T et al (2000) Identification of fractalkine, a CX3C-type chemokine, as a direct target of p531. Cancer Res 60(14):3722\u20133726","journal-title":"Cancer Res"},{"issue":"3","key":"10427_CR43","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3727\/096368909788534979","volume":"18","author":"S Hess","year":"2009","unstructured":"Hess S, Methe H, Kim JO, Edelman ER (2009) NF-\u03baB activity in endothelial cells is modulated by cell substratum interactions and influences chemokine-mediated adhesion of natural killer cells. Cell Transplant 18(3):261\u2013274. https:\/\/doi.org\/10.3727\/096368909788534979","journal-title":"Cell Transplant"},{"key":"10427_CR44","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.135343","author":"LA Johnson","year":"2013","unstructured":"Johnson LA, Jackson DG (2013) The chemokine CX3CL1 promotes trafficking of dendritic cells through inflamed lymphatics. J Cell Sci. https:\/\/doi.org\/10.1242\/jcs.135343","journal-title":"J Cell Sci"},{"issue":"11","key":"10427_CR45","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/PL00000230","volume":"50","author":"S Dichmann","year":"2001","unstructured":"Dichmann S, Herouy Y, Purlis D, Rheinen H, Gebicke-H\u00e4rter P, Norgauer J (2001) Fractalkine induces chemotaxis and actin polymerization in human dendritic cells. Inflamm Res 50(11):529\u2013533. https:\/\/doi.org\/10.1007\/PL00000230","journal-title":"Inflamm Res"},{"issue":"4","key":"10427_CR46","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0092-8674(00)80438-9","volume":"91","author":"T Imai","year":"1997","unstructured":"Imai T, Hieshima K, Haskell C et al (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91(4):521\u2013530. https:\/\/doi.org\/10.1016\/S0092-8674(00)80438-9","journal-title":"Cell"},{"issue":"11","key":"10427_CR47","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","volume":"20","author":"S Jung","year":"2000","unstructured":"Jung S, Aliberti J, Graemmel P et al (2000) Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20(11):4106\u20134114. https:\/\/doi.org\/10.1128\/MCB.20.11.4106-4114.2000","journal-title":"Mol Cell Biol"},{"key":"10427_CR48","doi-asserted-by":"publisher","unstructured":"Foussat A, Coulomb-L\u2019Hermine A, Gosling J, et al (2000). Fractalkine receptor expression by T lymphocyte subpopulations and in vivo production of fractalkine in human. Eur J Immunol 30(1):87\u201397. https:\/\/doi.org\/10.1002\/1521-4141(200001)30:187","DOI":"10.1002\/1521-4141(200001)30:187"},{"key":"10427_CR49","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.133920","author":"T Yamauchi","year":"2020","unstructured":"Yamauchi T, Hoki T, Oba T et al (2020) CX3CR1\u2013CD8+ T cells are critical in antitumor efficacy but functionally suppressed in the tumor microenvironment. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.133920","journal-title":"JCI Insight"},{"issue":"5","key":"10427_CR50","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1002\/eji.200526042","volume":"35","author":"H Xin","year":"2005","unstructured":"Xin H, Kikuchi T, Andarini S et al (2005) Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells. Eur J Immunol 35(5):1371\u20131380. https:\/\/doi.org\/10.1002\/eji.200526042","journal-title":"Eur J Immunol"},{"issue":"2","key":"10427_CR51","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1002\/ijc.10816","volume":"103","author":"J Guo","year":"2003","unstructured":"Guo J, Zhang M, Wang B et al (2003) Fractalkine transgene induces T-cell-dependent antitumor immunity through chemoattraction and activation of dendritic cells. Int J Cancer 103(2):212\u2013220. https:\/\/doi.org\/10.1002\/ijc.10816","journal-title":"Int J Cancer"},{"issue":"12","key":"10427_CR52","doi-asserted-by":"publisher","first-page":"4420","DOI":"10.1182\/blood-2007-12-126888","volume":"112","author":"JR Pallandre","year":"2008","unstructured":"Pallandre JR, Krzewski K, Bedel R et al (2008) Dendritic cell and natural killer cell cross-talk: a pivotal role of CX3CL1 in NK cytoskeleton organization and activation. Blood 112(12):4420\u20134424. https:\/\/doi.org\/10.1182\/blood-2007-12-126888","journal-title":"Blood"},{"issue":"2","key":"10427_CR53","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/ijc.22660","volume":"121","author":"YRA Yu","year":"2007","unstructured":"Yu YRA, Fong AM, Combadiere C, Gao JL, Murphy PM, Patel DD (2007) Defective antitumor responses in CX3CR1-deficient mice. Int J Cancer 121(2):316\u2013322. https:\/\/doi.org\/10.1002\/ijc.22660","journal-title":"Int J Cancer"},{"issue":"1","key":"10427_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0165-2478(03)00101-9","volume":"89","author":"J Guo","year":"2003","unstructured":"Guo J, Chen T, Wang B et al (2003) Chemoattraction, adhesion and activation of natural killer cells are involved in the antitumor immune response induced by fractalkine\/CX3CL1. Immunol Lett 89(1):1\u20137. https:\/\/doi.org\/10.1016\/S0165-2478(03)00101-9","journal-title":"Immunol Lett"},{"issue":"16","key":"10427_CR55","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1038\/sj.gt.3302959","volume":"14","author":"L Tang","year":"2007","unstructured":"Tang L, Hu H, Hu P et al (2007) Gene therapy with CX3CL1\/Fractalkine induces antitumor immunity to regress effectively mouse hepatocellular carcinoma. Gene Ther 14(16):1226\u20131234. https:\/\/doi.org\/10.1038\/sj.gt.3302959","journal-title":"Gene Ther"},{"issue":"6","key":"10427_CR56","doi-asserted-by":"publisher","first-page":"4877","DOI":"10.3892\/ol.2019.10211","volume":"17","author":"J Liu","year":"2019","unstructured":"Liu J, Li Y, Zhu X et al (2019) Increased CX3CL1 mRNA expression level is a positive prognostic factor in patients with lung adenocarcinoma. Oncol Lett 17(6):4877\u20134890. https:\/\/doi.org\/10.3892\/ol.2019.10211","journal-title":"Oncol Lett"},{"issue":"6","key":"10427_CR57","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1245\/s10434-008-9876-3","volume":"15","author":"M Hyakudomi","year":"2008","unstructured":"Hyakudomi M, Matsubara T, Hyakudomi R et al (2008) Increased expression of fractalkine is correlated with a better prognosis and an increased number of both CD8+ T cells and natural killer cells in gastric adenocarcinoma. Ann Surg Oncol 15(6):1775\u20131782. https:\/\/doi.org\/10.1245\/s10434-008-9876-3","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"10427_CR58","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1136\/gut.2005.088989","volume":"56","author":"S Vitale","year":"2007","unstructured":"Vitale S et al (2007) Tissue-specific differential antitumour effect of molecular forms of fractalkine in a mouse model of metastatic colon cancer. Gut 56(3):365\u2013372. https:\/\/doi.org\/10.1136\/gut.2005.088989","journal-title":"Gut"},{"issue":"6","key":"10427_CR59","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.cellsig.2010.10.015","volume":"23","author":"M Tian","year":"2011","unstructured":"Tian M, Neil JR, Schiemann WP (2011) Transforming growth factor-\u03b2 and the hallmarks of cancer. Cell Signal 23(6):951\u2013962. https:\/\/doi.org\/10.1016\/j.cellsig.2010.10.015","journal-title":"Cell Signal"},{"issue":"3","key":"10427_CR60","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1245\/s10434-015-4804-9","volume":"22","author":"CT Wu","year":"2015","unstructured":"Wu CT, Chang YH, Lin WY, Chen WC, Chen MF (2015) TGF beta1 expression correlates with survival and tumor aggressiveness of prostate cancer. Ann Surg Oncol 22(3):1587\u20131593. https:\/\/doi.org\/10.1245\/s10434-015-4804-9","journal-title":"Ann Surg Oncol"},{"key":"10427_CR61","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00868","author":"S Regis","year":"2017","unstructured":"Regis S, Caliendo F, Dondero A et al (2017) TGF-\u03b21 downregulates the expression of CX3CR1 by inducing miR-27a-5p in primary human NK cells. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2017.00868","journal-title":"Front Immunol"},{"issue":"10","key":"10427_CR62","doi-asserted-by":"publisher","first-page":"5321","DOI":"10.4049\/jimmunol.1202693","volume":"190","author":"R Castriconi","year":"2013","unstructured":"Castriconi R, Dondero A, Bellora F et al (2013) Neuroblastoma-derived TGF-\u03b21 modulates the chemokine receptor repertoire of human resting NK cells. J Immunol 190(10):5321\u20135328. https:\/\/doi.org\/10.4049\/jimmunol.1202693","journal-title":"J Immunol"},{"issue":"2","key":"10427_CR63","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1053\/j.semnuclmed.2014.10.002","volume":"45","author":"PN Span","year":"2015","unstructured":"Span PN, Bussink J (2015) Biology of Hypoxia. Semin Nucl Med 45(2):101\u2013109. https:\/\/doi.org\/10.1053\/j.semnuclmed.2014.10.002","journal-title":"Semin Nucl Med"},{"issue":"16","key":"10427_CR64","doi-asserted-by":"publisher","first-page":"4779","DOI":"10.7150\/thno.32543","volume":"9","author":"EB Chen","year":"2019","unstructured":"Chen EB, Zhou ZJ, Xiao K et al (2019) The miR-561-5p\/CX3CL1 signaling axis regulates pulmonary metastasis in hepatocellular carcinoma involving CX3CR1+ natural killer cells infiltration. Theranostics 9(16):4779\u20134794. https:\/\/doi.org\/10.7150\/thno.32543","journal-title":"Theranostics"},{"issue":"8","key":"10427_CR65","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1007\/s11605-012-1921-7","volume":"16","author":"X Xu","year":"2012","unstructured":"Xu X, Wang Y, Chen J et al (2012) High expression of CX3CL1\/CX3CR1 axis predicts a poor prognosis of pancreatic ductal adenocarcinoma. J Gastrointest Surg 16(8):1493\u20131498. https:\/\/doi.org\/10.1007\/s11605-012-1921-7","journal-title":"J Gastrointest Surg"},{"issue":"20","key":"10427_CR66","first-page":"4595","volume":"21","author":"J Sun","year":"2017","unstructured":"Sun J, Li DM, Huang J, Liu J, Sun B, Fu DL, Mao GS (2017) The correlation between the expression of ADAM17, EGFR and Ki-67 in malignant gliomas. Eur Rev Med Pharmacol Sci 21(20):4595\u20134599","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"5","key":"10427_CR67","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.3892\/ijo.23.5.1365","volume":"23","author":"D Karan","year":"2003","unstructured":"Karan D, Lin FC, Bryan M et al (2003) Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas. Int J Oncol 23(5):1365\u20131371. https:\/\/doi.org\/10.3892\/ijo.23.5.1365","journal-title":"Int J Oncol"},{"issue":"3","key":"10427_CR68","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1158\/0008-5472.CAN-08-1946","volume":"69","author":"D Castellana","year":"2009","unstructured":"Castellana D, Zobairi F, Martinez MC et al (2009) Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: a role for activated fibroblasts and CX3CL1-CX3CR1 axis. Cancer Res 69(3):785\u2013793. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-1946","journal-title":"Cancer Res"},{"issue":"21","key":"10427_CR69","doi-asserted-by":"publisher","first-page":"9060","DOI":"10.1158\/0008-5472.CAN-08-1810","volume":"68","author":"F Marchesi","year":"2008","unstructured":"Marchesi F, Piemonti L, Fedele G et al (2008) The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma. Cancer Res 68(21):9060\u20139069. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-1810","journal-title":"Cancer Res"},{"issue":"4","key":"10427_CR70","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1016\/j.bbrc.2017.10.006","volume":"493","author":"L Huang","year":"2017","unstructured":"Huang L, Ma B, Ma J, Wang F (2017) Fractalkine\/CX3CR1 axis modulated the development of pancreatic ductal adenocarcinoma via JAK\/STAT signaling pathway. Biochem Biophys Res Commun 493(4):1510\u20131517. https:\/\/doi.org\/10.1016\/j.bbrc.2017.10.006","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"10427_CR71","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/mc.22787","volume":"57","author":"YC Su","year":"2018","unstructured":"Su YC, Chang H, Sun SJ et al (2018) Differential impact of CX3CL1 on lung cancer prognosis in smokers and non-smokers. Mol Carcinog 57(5):629\u2013639. https:\/\/doi.org\/10.1002\/mc.22787","journal-title":"Mol Carcinog"},{"issue":"26","key":"10427_CR72","doi-asserted-by":"publisher","first-page":"14608","DOI":"10.1073\/pnas.97.26.14608","volume":"97","author":"YS Chang","year":"2000","unstructured":"Chang YS, di Tomaso E, McDonald DM, Jones R, Jain RK, Munn LL (2000) Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood. Proc Natl Acad Sci USA 97(26):14608\u201314613. https:\/\/doi.org\/10.1073\/pnas.97.26.14608","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"10427_CR73","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1158\/0008-5472.CAN-07-1315","volume":"68","author":"WL Jamieson","year":"2008","unstructured":"Jamieson WL, Shimizu S, D\u2019Ambrosio JA, Meucci O, Fatatis A (2008) CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1\/fractalkine in the bone marrow: potential role in prostate cancer bone tropism. Cancer Res 68(6):1715\u20131722. https:\/\/doi.org\/10.1158\/0008-5472.CAN-07-1315","journal-title":"Cancer Res"},{"issue":"3","key":"10427_CR74","doi-asserted-by":"publisher","first-page":"670","DOI":"10.4149\/neo_2022_211205N1728","volume":"69","author":"HU An-Nan","year":"2022","unstructured":"An-Nan HU et al (2022) CX3CL1 in the red bone marrow promotes renal cell carcinoma to metastasize to the spine by involving the Src-related pathway. Neoplasma 69(3):670. https:\/\/doi.org\/10.4149\/neo_2022_211205N1728","journal-title":"Neoplasma"},{"issue":"10","key":"10427_CR75","doi-asserted-by":"publisher","first-page":"4770","DOI":"10.7150\/thno.54235","volume":"11","author":"K Wang","year":"2021","unstructured":"Wang K et al (2021) Vertebral-specific activation of the CX3CL1\/ICAM-1 signaling network mediates non-small-cell lung cancer spinal metastasis by engaging tumor cell-vertebral bone marrow endothelial cell interactions. Theranostics 11(10):4770. https:\/\/doi.org\/10.7150\/thno.54235","journal-title":"Theranostics"},{"issue":"1","key":"10427_CR76","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s10555-011-9332-x","volume":"31","author":"D Cossigny","year":"2012","unstructured":"Cossigny D, Quan GMY (2012) In vivo animal models of spinal metastasis. Cancer Metastasis Rev 31(1):99\u2013108. https:\/\/doi.org\/10.1007\/s10555-011-9332-x","journal-title":"Cancer Metastasis Rev"},{"issue":"7","key":"10427_CR77","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1097\/BRS.0b013e3181d8906f","volume":"36","author":"H Liang","year":"2011","unstructured":"Liang H, Ma SY, Mohammad K, Guise TA, Balian G, Shen FH (2011) The reaction of bone to tumor growth from human breast cancer cells in a rat spine single metastasis model. Spine 36(7):497. https:\/\/doi.org\/10.1097\/BRS.0b013e3181d8906f","journal-title":"Spine"},{"issue":"5","key":"10427_CR78","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3171\/spi.2006.4.5.388","volume":"4","author":"J Schuster","year":"2006","unstructured":"Schuster J, Zhang J, Longo M (2006) A novel human osteoblast\u2013derived severe combined immunodeficiency mouse model of bone metastasis. J Neurosurg Spine 4(5):388\u2013391. https:\/\/doi.org\/10.3171\/spi.2006.4.5.388","journal-title":"J Neurosurg Spine"},{"issue":"6","key":"10427_CR79","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3171\/2009.2","volume":"10","author":"CE Tatsui","year":"2009","unstructured":"Tatsui CE, Lang FF, Gumin J, Suki D, Shinojima N, Rhines LD (2009) An orthotopic murine model of human spinal metastasis: histological and functional correlations. J Neurosurg Spine 10(6):501\u2013512. https:\/\/doi.org\/10.3171\/2009.2","journal-title":"J Neurosurg Spine"},{"issue":"2","key":"10427_CR80","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s10549-009-0356-7","volume":"119","author":"MK Akens","year":"2010","unstructured":"Akens MK, Hardisty MR, Wilson BC et al (2010) Defining the therapeutic window of vertebral photodynamic therapy in a murine pre-clinical model of breast cancer metastasis using the photosensitizer BPD-MA (Verteporfin). Breast Cancer Res Treat 119(2):325\u2013333. https:\/\/doi.org\/10.1007\/s10549-009-0356-7","journal-title":"Breast Cancer Res Treat"},{"issue":"5","key":"10427_CR81","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s10585-010-9329-9","volume":"27","author":"A Strube","year":"2010","unstructured":"Strube A, Stepina E, Mumberg D, Scholz A, Hauff P, K\u00e4k\u00f6nen SM (2010) Characterization of a new renal cell carcinoma bone metastasis mouse model. Clin Exp Metastasis 27(5):319\u2013330. https:\/\/doi.org\/10.1007\/s10585-010-9329-9","journal-title":"Clin Exp Metastasis"},{"issue":"5","key":"10427_CR82","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1111\/j.1751-1097.2007.00172.x","volume":"83","author":"MK Akens","year":"2007","unstructured":"Akens MK, Yee AJM, Wilson BC et al (2007) Photodynamic therapy of vertebral metastases: evaluating tumor-to-neural tissue uptake of BPD-MA and ALA-PpIX in a murine model of metastatic human breast carcinoma. Photochem Photobiol 83(5):1034\u20131039. https:\/\/doi.org\/10.1111\/j.1751-1097.2007.00172.x","journal-title":"Photochem Photobiol"},{"key":"10427_CR83","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1097\/01.blo.0000238787.44349.eb","volume":"454","author":"S Burch","year":"2007","unstructured":"Burch S, Bisland SK, Wilson BC, Whyne C, Yee AJM (2007) Multimodality imaging for vertebral metastases in a rat osteolytic model. Clin Orthop Relat Res 454:230. https:\/\/doi.org\/10.1097\/01.blo.0000238787.44349.eb","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"10427_CR84","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/MNM.0b013e3282f258c1","volume":"29","author":"L Wang","year":"2008","unstructured":"Wang L, Yao Q, Wang J et al (2008) MRI and hybrid PET\/CT for monitoring tumour metastasis in a metastatic breast cancer model in rabbit. Nucl Med Commun 29(2):137. https:\/\/doi.org\/10.1097\/MNM.0b013e3282f258c1","journal-title":"Nucl Med Commun"},{"issue":"1","key":"10427_CR85","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1189\/jlb.0112035","volume":"92","author":"A Corcione","year":"2012","unstructured":"Corcione A, Ferretti E, Pistoia V (2012) CX3CL1\/fractalkine is a novel regulator of normal and malignant human B cell function. J Leukoc Biol 92(1):51\u201358. https:\/\/doi.org\/10.1189\/jlb.0112035","journal-title":"J Leukoc Biol"},{"issue":"7","key":"10427_CR86","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/nrc1388","volume":"4","author":"F Balkwill","year":"2004","unstructured":"Balkwill F (2004) Cancer and the chemokine network. Nat Rev Cancer 4(7):540\u2013550. https:\/\/doi.org\/10.1038\/nrc1388","journal-title":"Nat Rev Cancer"},{"key":"10427_CR87","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2026.05.016","author":"A Birbrair","year":"2026","unstructured":"Birbrair A, Simon DJ, Talbot S, Zhou S (2026) Context dependency in cancer neuroscience. Cancer Cell. https:\/\/doi.org\/10.1016\/j.ccell.2026.05.016","journal-title":"Cancer Cell"},{"key":"10427_CR88","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.cytogfr.2026.01.006","volume":"88","author":"J Liang","year":"2026","unstructured":"Liang J, Zhu W, Pan R, Wei S, Zhang S, Zhang Z, Tian H (2026) Spatiotemporal dynamic regulation of the CX3CL1-CX3CR1 axis: a double-edged sword in the tumor immune microenvironment and new strategies for precision therapy. Cytokine Growth Factor Rev 88:67\u201379. https:\/\/doi.org\/10.1016\/j.cytogfr.2026.01.006","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"10427_CR89","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01506-y","volume":"21","author":"V Richard","year":"2022","unstructured":"Richard V, Davey MG, Annuk H, Miller N, Kerin MJ (2022) The double agents in liquid biopsy: promoter and informant biomarkers of early metastases in breast cancer. Mol Cancer 21(1):95. https:\/\/doi.org\/10.1186\/s12943-022-01506-y","journal-title":"Mol Cancer"},{"issue":"1","key":"10427_CR90","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/s41698-025-00876-y","volume":"9","author":"A Bartolomucci","year":"2025","unstructured":"Bartolomucci A, Nobrega M, Ferrier T, Dickinson K, Kaorey N, Nadeau A, Castillo A, Burnier JV (2025) Circulating tumor DNA to monitor treatment response in solid tumors and advance precision oncology. NPJ Precis Oncol 9(1):84. https:\/\/doi.org\/10.1038\/s41698-025-00876-y","journal-title":"NPJ Precis Oncol"},{"key":"10427_CR91","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-024-00657-z","volume":"8","author":"FW Janssen","year":"2024","unstructured":"Janssen FW, Lak NSM, Janda CY et al (2024) A comprehensive overview of liquid biopsy applications in pediatric solid tumors. npj Precis Oncol 8:172. https:\/\/doi.org\/10.1038\/s41698-024-00657-z","journal-title":"npj Precis Oncol"},{"issue":"3","key":"10427_CR92","doi-asserted-by":"publisher","first-page":"3064","DOI":"10.3390\/curroncol30030232","volume":"30","author":"A Chalamgari","year":"2023","unstructured":"Chalamgari A, Valle D, Palau Villarreal X, Foreman M, Liu A, Patel A, Dave A, Lucke-Wold B (2023) Vertebral primary bone lesions: review of management options. Curr Oncol 30(3):3064\u20133078. https:\/\/doi.org\/10.3390\/curroncol30030232","journal-title":"Curr Oncol"},{"issue":"1","key":"10427_CR93","doi-asserted-by":"publisher","DOI":"10.3390\/life15010008","volume":"15","author":"AA Mohamed","year":"2024","unstructured":"Mohamed AA, Alshaibi R, Faragalla S, Flynn G, Khan A, Sargent E, Mohamed Y, Moriconi C, Williams C, Karve Z, Colome D, Johansen PM, Lucke-Wold B (2024) Less is more: evaluating the benefits of minimally invasive spinal surgery. Life (Basel) 15(1):8. https:\/\/doi.org\/10.3390\/life15010008","journal-title":"Life (Basel)"},{"key":"10427_CR94","doi-asserted-by":"publisher","unstructured":"MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hr\u00f3bjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 372:n71. https:\/\/doi.org\/10.1136\/bmj","DOI":"10.1136\/bmj"}],"container-title":["Clinical & Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-026-10427-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10585-026-10427-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-026-10427-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T23:04:20Z","timestamp":1788131060000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10585-026-10427-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,30]]},"references-count":94,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["10427"],"URL":"https:\/\/doi.org\/10.1007\/s10585-026-10427-9","relation":{},"ISSN":["1573-7276"],"issn-type":[{"value":"1573-7276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,30]]},"assertion":[{"value":"12 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"N\/A.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"46"}}