{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:44:17Z","timestamp":1792269857002,"version":"4.4.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Quanzhou Science and Technology Plan Project","award":["2023NS067"],"award-info":[{"award-number":["2023NS067"]}]},{"name":"Xiamen Science and Technology Plan Project for High-Quality Development of Health and Wellness","award":["2024GZL-CX16 and 2024GZL-GG58"],"award-info":[{"award-number":["2024GZL-CX16 and 2024GZL-GG58"]}]},{"name":"Natural Science Foundation of Fujian Province","award":["2026J0011773"],"award-info":[{"award-number":["2026J0011773"]}]},{"name":"the Medical and Health Guidance Projects of Xiamen City","award":["3502Z20254ZD1002"],"award-info":[{"award-number":["3502Z20254ZD1002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Metastasis"],"DOI":"10.1007\/s10585-026-10438-6","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:05:18Z","timestamp":1792224318000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brachytherapy-based local radiotherapy improves survival in newly diagnosed metastatic cervical cancer"],"prefix":"10.1007","volume":"43","author":[{"given":"Qing-Xiang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-2614","authenticated-orcid":false,"given":"San-Gang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"issue":"3","key":"10438_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229\u2013263. https:\/\/doi.org\/10.3322\/caac.21834","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"10438_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.ygyno.2019.08.022","volume":"155","author":"M Bjurberg","year":"2019","unstructured":"Bjurberg M, Holmberg E, Borgfeldt C, Fl\u00f6ter-R\u00e5destad A, Dahm-K\u00e4hler P, Hjerpe E, H\u00f6gberg T, Kj\u00f8lhede P, Marcickiewicz J, Rosenberg P, St\u00e5lberg K, Tholander B, Hellman K, \u00c5vall-Lundqvist E (2019) Primary treatment patterns and survival of cervical cancer in Sweden: A population-based Swedish Gynecologic Cancer Group Study. Gynecol Oncol 155(2):229\u2013236. https:\/\/doi.org\/10.1016\/j.ygyno.2019.08.022","journal-title":"Gynecol Oncol"},{"key":"10438_CR3","doi-asserted-by":"publisher","first-page":"1567296","DOI":"10.3389\/fimmu.2025.1567296","volume":"16","author":"J Zeng","year":"2025","unstructured":"Zeng J, Yin R (2025) Rethinking treatment approaches for FIGO stage IVB cervical cancer: personalized strategies and emerging therapies. Front Immunol 16:1567296. https:\/\/doi.org\/10.3389\/fimmu.2025.1567296","journal-title":"Front Immunol"},{"issue":"1","key":"10438_CR4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s13014-023-02320-6","volume":"18","author":"J Li","year":"2023","unstructured":"Li J, Wang Y, Huo L, Huang X, Shi L, Huang L, Chen K, Cao X (2023) Definitive irradiation as a first treatment strategy for primary and metastatic sites of newly diagnosed IVB cervical cancer that presented with synchronous oligometastases. Radiat Oncol 18(1):159. https:\/\/doi.org\/10.1186\/s13014-023-02320-6","journal-title":"Radiat Oncol"},{"issue":"2","key":"10438_CR5","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00404-022-06611-3","volume":"307","author":"S Joh","year":"2023","unstructured":"Joh S, Violette CJ, Khetan VU, Tavakoli A, Jooya ND, Cahoon SS, Klar M, Roman LD, Matsuo K (2023) Metastatic extent-specific prognosis of women with stage IVB cervical cancer: multiple versus single distant organ involvement. Arch Gynecol Obstet 307(2):533\u2013540. https:\/\/doi.org\/10.1007\/s00404-022-06611-3","journal-title":"Arch Gynecol Obstet"},{"key":"10438_CR6","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.ygyno.2024.10.023","volume":"191","author":"KS Hunsberger","year":"2024","unstructured":"Hunsberger KS, Tewari KS, Monk BJ, Chase DM (2024) Standard of care treatment for stage IVB cervical cancer: a systematic review and meta-analysis. Gynecol Oncol 191:259\u2013264. https:\/\/doi.org\/10.1016\/j.ygyno.2024.10.023","journal-title":"Gynecol Oncol"},{"issue":"2","key":"10438_CR7","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/cac2.12629","volume":"45","author":"M Xu","year":"2025","unstructured":"Xu M, Cao C, Wu P, Huang X, Ma D (2025) Advances in cervical cancer: current insights and future directions. Cancer Commun (Lond) 45(2):77\u2013109. https:\/\/doi.org\/10.1002\/cac2.12629","journal-title":"Cancer Commun (Lond)"},{"issue":"6","key":"10438_CR8","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1007\/s11864-025-01325-5","volume":"26","author":"UG Gardner","year":"2025","unstructured":"Gardner UG, Viswanathan AN (2025) Management of stage IVB cervical cancer including the role of radiotherapy. Curr Treat Options Oncol 26(6):524\u2013532. https:\/\/doi.org\/10.1007\/s11864-025-01325-5","journal-title":"Curr Treat Options Oncol"},{"issue":"3","key":"10438_CR9","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.ygyno.2022.04.013","volume":"165","author":"JY Xu","year":"2022","unstructured":"Xu JY, Chen JN, Lei J, Hu M, Wu SG, Zhou J (2022) Local treatment improves survival in patients with stage IVB cervical cancer. Gynecol Oncol 165(3):538\u2013545. https:\/\/doi.org\/10.1016\/j.ygyno.2022.04.013","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10438_CR10","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1002\/ijgo.15121","volume":"164","author":"JY Xu","year":"2024","unstructured":"Xu JY, Hu M, Wu SG, Zhou J (2024) Local treatment strategies in Stage IVB cervical squamous cell carcinoma and adenocarcinoma. Int J Gynaecol Obstet 164(3):1053\u20131063. https:\/\/doi.org\/10.1002\/ijgo.15121","journal-title":"Int J Gynaecol Obstet"},{"issue":"13","key":"10438_CR11","doi-asserted-by":"publisher","first-page":"11013","DOI":"10.1007\/s00432-023-04988-5","volume":"149","author":"Y He","year":"2023","unstructured":"He Y, Zhang Y, Hu S, Zhang B, Zhang Z, Yao Y, Wang X (2023) Primary tumor resection improves survival benefit of stage IVB cervical carcinoma: a new perspective. J Cancer Res Clin Oncol 149(13):11013\u201311023. https:\/\/doi.org\/10.1007\/s00432-023-04988-5","journal-title":"J Cancer Res Clin Oncol"},{"issue":"3","key":"10438_CR12","doi-asserted-by":"publisher","first-page":"e42","DOI":"10.3802\/jgo.2025.36.e42","volume":"36","author":"H Li","year":"2025","unstructured":"Li H, Wu J, Xu Q, Chen Y, Cheng X (2025) Different surgical methods for FIGO stage IVB cervical cancer patients receiving chemotherapy: a population-based study. J Gynecol Oncol 36(3):e42. https:\/\/doi.org\/10.3802\/jgo.2025.36.e42","journal-title":"J Gynecol Oncol"},{"issue":"8","key":"10438_CR13","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1097\/IGC.0000000000001350","volume":"28","author":"A Fagotti","year":"2018","unstructured":"Fagotti A, Conte C, Stollagli F, Gallotta V, Salutari V, Bottoni C, Bruno M, Zannoni GF, Scambia G (2018) Radical surgery in advanced cervical cancer patients receiving bevacizumab-containing chemotherapy: a real life experience. Int J Gynecol Cancer 28(8):1569\u20131575. https:\/\/doi.org\/10.1097\/IGC.0000000000001350","journal-title":"Int J Gynecol Cancer"},{"issue":"1","key":"10438_CR14","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/ijgo.15609","volume":"167","author":"ST Yang","year":"2024","unstructured":"Yang ST, Liu HH, Liu CH, Wang LW, Wang PH (2024) Bevacizumab is associated with a higher gastrointestinal\/genitourinary fistula or perforation risk in cervical cancer patients undergoing pelvic radiotherapy. Int J Gynaecol Obstet 167(1):80\u201387. https:\/\/doi.org\/10.1002\/ijgo.15609","journal-title":"Int J Gynaecol Obstet"},{"key":"10438_CR15","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ygyno.2022.11.009","volume":"169","author":"S Vieira-Serna","year":"2023","unstructured":"Vieira-Serna S, Viveros-Carre\u00f1o D, Rodr\u00edguez J, Grillo-Ardila CF, Angeles MA, Guerrero E, Sanabria D, Pareja R (2023) Preoperative brachytherapy for early-stage cervical cancer: systematic review and meta-analysis. Gynecol Oncol 169:4\u201311. https:\/\/doi.org\/10.1016\/j.ygyno.2022.11.009","journal-title":"Gynecol Oncol"},{"key":"10438_CR16","unstructured":"Surveillance E, Results E (2024) (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence - SEER Research Limited-Field Data, 21 Registries, Nov 2024 Sub (2000\u20132022), National Cancer Institute, DCCPS, Surveillance Research Program, released April 2025, based on the November submission"},{"key":"10438_CR17","unstructured":"National Comprehensive Cancer Network (2025) (NCCN) clinical practice guidelines in Oncology. Cerv Cancer Version 1. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/cervical.pdf"},{"issue":"6","key":"10438_CR18","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1136\/ijgc-2020-001200","volume":"30","author":"SH Youn","year":"2020","unstructured":"Youn SH, Kim YJ, Seo SS, Kang S, Lim MC, Chang HK, Park SY, Kim JY (2020) Effect of addition of bevacizumab to chemoradiotherapy in newly diagnosed stage IVB cervical cancer: a single institution experience in Korea. Int J Gynecol Cancer 30(6):764\u2013771. https:\/\/doi.org\/10.1136\/ijgc-2020-001200","journal-title":"Int J Gynecol Cancer"},{"issue":"3","key":"10438_CR19","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1159\/000500025","volume":"97","author":"S Espenel","year":"2019","unstructured":"Espenel S, Garcia MA, Langrand-Escure J, Vallard A, Trone JC, Rancoule C, Vial N, Moreno-Acosta P, Chauleur C, Boutet C, Peoc Apos HM, Prevot-Bitot N, Guy JB, Magn\u00e9 N (2019) Special focus on stage IV cervical cancer patients: a decade experience. Oncology 97(3):125\u2013134. https:\/\/doi.org\/10.1159\/000500025","journal-title":"Oncology"},{"issue":"2","key":"10438_CR20","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.brachy.2020.11.001","volume":"20","author":"L Ding","year":"2021","unstructured":"Ding L, Bi Z, Pan Z, Yu X, Zhao X, Bai S, Yao H, Liu Y (2021) Brachytherapy-based radiotherapy is associated with improved survival for newly diagnosed metastatic cervical cancer. Brachytherapy 20(2):361\u2013367. https:\/\/doi.org\/10.1016\/j.brachy.2020.11.001","journal-title":"Brachytherapy"},{"issue":"7","key":"10438_CR21","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1136\/ijgc-2023-004465","volume":"33","author":"D Viveros-Carre\u00f1o","year":"2023","unstructured":"Viveros-Carre\u00f1o D, Vieira-Serna S, Grillo-Ardila CF, Rodriguez J, Mora-Soto N, Jhingran A, Ramirez PT, Pareja R (2023) Definitive pelvic radiotherapy for patients with newly diagnosed stage IVB cervical cancer: a systematic review. Int J Gynecol Cancer 33(7):1057\u20131062. https:\/\/doi.org\/10.1136\/ijgc-2023-004465","journal-title":"Int J Gynecol Cancer"},{"issue":"4","key":"10438_CR22","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.21037\/tcr.2019.07.21","volume":"8","author":"H Li","year":"2019","unstructured":"Li H, Yang Y, Zhou H, Liu F, Li M, Chen L, Wu X, Cheng X (2019) Clinicopathologic characteristics and survival analysis in stage IVB cervical cancer with hematogenous metastasis. Transl Cancer Res 8(4):1217\u20131223. https:\/\/doi.org\/10.21037\/tcr.2019.07.21","journal-title":"Transl Cancer Res"},{"issue":"3","key":"10438_CR23","doi-asserted-by":"publisher","first-page":"193","DOI":"10.4143\/crt.2013.45.3.193","volume":"45","author":"HS Kim","year":"2013","unstructured":"Kim HS, Kim T, Lee ES, Kim HJ, Chung HH, Kim JW, Song YS, Park NH (2013) Impact of chemoradiation on prognosis in stage IVB cervical cancer with distant lymphatic metastasis. Cancer Res Treat 45(3):193\u2013201. https:\/\/doi.org\/10.4143\/crt.2013.45.3.193","journal-title":"Cancer Res Treat"},{"issue":"5","key":"10438_CR24","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1136\/ijgc-2022-004224","volume":"33","author":"S Peleg Hasson","year":"2023","unstructured":"Peleg Hasson S, Felder S, Helpman L, Taylor A, Shalamov M, Abuakar S, Bauer S, Shapira-Frommer R, Greenhouse I, Korach J, Rabin T, Goldstein J, Saad A (2023) Outcomes associated with treatment to all sites of disease in patients with stage IVB cancer of the cervix. Int J Gynecol Cancer 33(5):683\u2013691. https:\/\/doi.org\/10.1136\/ijgc-2022-004224","journal-title":"Int J Gynecol Cancer"},{"issue":"7","key":"10438_CR25","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1097\/IGC.0000000000001313","volume":"28","author":"K Huang","year":"2018","unstructured":"Huang K, Jia M, Li P, Han J, Zhang R, Li Q, Qiao Y, Xu T, Ruan P, Song Q, Li Y, Fu Z (2018) Radiotherapy improves the survival of patients with metastatic cervical cancer: a propensity-matched analysis of SEER database. Int J Gynecol Cancer 28(7):1360\u20131368. https:\/\/doi.org\/10.1097\/IGC.0000000000001313","journal-title":"Int J Gynecol Cancer"},{"issue":"1","key":"10438_CR26","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.ygyno.2019.10.033","volume":"156","author":"V Perkins","year":"2020","unstructured":"Perkins V, Moore K, Vesely S, Matsuo K, Mostofizadeh S, Sims TT, Lea J, Barnes D, Chen S, Carlson M, Roman L, Monk BJ, Holman LL (2020) Incorporation of whole pelvic radiation into treatment of stage IVB cervical cancer: A novel treatment strategy. Gynecol Oncol 156(1):100\u2013106. https:\/\/doi.org\/10.1016\/j.ygyno.2019.10.033","journal-title":"Gynecol Oncol"},{"issue":"2","key":"10438_CR27","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1159\/000337985","volume":"83","author":"M Hata","year":"2012","unstructured":"Hata M, Omura M, Miyagi E, Koike I, Numazaki R, Asai-Sato M, Tayama Y, Ogino I, Hirahara F, Inoue T (2012) The role of radiation therapy for uterine cervical cancer with distant metastasis. Oncology 83(2):67\u201374. https:\/\/doi.org\/10.1159\/000337985","journal-title":"Oncology"}],"container-title":["Clinical & Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-026-10438-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10585-026-10438-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-026-10438-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:02:53Z","timestamp":1792267373000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10585-026-10438-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,17]]},"references-count":27,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10438"],"URL":"https:\/\/doi.org\/10.1007\/s10585-026-10438-6","relation":{},"ISSN":["1573-7276"],"issn-type":[{"value":"1573-7276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,17]]},"assertion":[{"value":"17 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Since this study used the publicly available SEER database, approval from the institutional review board was waived.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research was conducted on humans in accordance with the Helsinki Declaration of 1975, as revised in 2013 [\n                      \n                      ].","order":3,"name":"Ethics","label":"Human and animal rights","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"57"}}