{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:18:25Z","timestamp":1777544305856,"version":"3.51.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004386","name":"University of Malaya","doi-asserted-by":"crossref","award":["UMRG: RP040B-15HTM"],"award-info":[{"award-number":["UMRG: RP040B-15HTM"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia (MY)","doi-asserted-by":"publisher","award":["MOHE High Impact Research Grant: UM.C\/HIR\/MOHE\/ENG\/44"],"award-info":[{"award-number":["MOHE High Impact Research Grant: UM.C\/HIR\/MOHE\/ENG\/44"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cytotechnology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s10616-015-9939-9","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T05:12:57Z","timestamp":1451884377000},"page":"1859-1872","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The effects of hypoxia and serum-free conditions on the stemness properties of human adipose-derived stem cells"],"prefix":"10.1007","volume":"68","author":[{"given":"Wan Kamarul Zaman","family":"Wan Safwani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin Wei","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kar Wey","family":"Yong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane Ru","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor Azmi","family":"Mat Adenan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siti Zawiah","family":"Omar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Abu Bakar","family":"Wan Abas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda","family":"Pingguan-Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,1,4]]},"reference":[{"key":"9939_CR1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/jcb.22768","volume":"111","author":"MC Arufe","year":"2010","unstructured":"Arufe MC, De la Fuente A, Fuentes I, de Toro FJ, Blanco FJ (2010) Chondrogenic potential of subpopulations of cells expressing mesenchymal stem cell markers derived from human synovial membranes. J Cell Biochem 111:834\u2013845","journal-title":"J Cell Biochem"},{"key":"9939_CR2","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.3390\/cells1041107","volume":"1","author":"DD Campbell","year":"2012","unstructured":"Campbell DD, Pei M (2012) Surface markers for chondrogenic determination: a highlight of synovium-derived stem cells. Cells 1:1107\u20131120","journal-title":"Cells"},{"key":"9939_CR3","first-page":"328","volume":"4","author":"JR Choi","year":"2014","unstructured":"Choi JR, Pingguan-Murphy B, Abas WABW, Azmi MAN, Omar SZ, Chua KH, Safwani WKZW (2014a) Hypoxia promotes growth and viability of human adipose-derived stem cells with increased growth factors secretion. J Asian Sci Res 4:328\u2013338","journal-title":"J Asian Sci Res"},{"key":"9939_CR4","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bbrc.2014.04.096","volume":"448","author":"JR Choi","year":"2014","unstructured":"Choi JR, Pingguan-Murphy B, Wan Abas WA, Noor Azmi MA, Omar SZ, Chua KH, Wan Safwani WK (2014b) Impact of low oxygen tension on stemness, proliferation and differentiation potential of human adipose-derived stem cells. Biochem Biophys Res Commun 448:218\u2013224","journal-title":"Biochem Biophys Res Commun"},{"key":"9939_CR5","doi-asserted-by":"crossref","first-page":"e0115034","DOI":"10.1371\/journal.pone.0115034","volume":"10","author":"JR Choi","year":"2015","unstructured":"Choi JR, Pingguan-Murphy B, Wan Abas WA, Yong KW, Poon CT, Noor Azmi MA, Omar SZ, Chua KH, Xu F, Wan Safwani WK (2015) In situ normoxia enhances survival and proliferation rate of human adipose tissue-derived stromal cells without increasing the risk of tumourigenesis. PLoS One 10:e0115034","journal-title":"PLoS One"},{"key":"9939_CR6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy 8:315\u2013317","journal-title":"Cytotherapy"},{"key":"9939_CR7","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1126\/science.1238363","volume":"342","author":"S Doulatov","year":"2013","unstructured":"Doulatov S, Daley GQ (2013) Development. A stem cell perspective on cellular engineering. Science 342:700\u2013702","journal-title":"Science"},{"key":"9939_CR8","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1474-9726.2007.00336.x","volume":"6","author":"C Fehrer","year":"2007","unstructured":"Fehrer C, Brunauer R, Laschober G, Unterluggauer H, Reitinger S, Kloss F, Gully C, Gassner R, Lepperdinger G (2007) Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan. Aging Cell 6:745\u2013757","journal-title":"Aging Cell"},{"key":"9939_CR9","doi-asserted-by":"crossref","first-page":"56","DOI":"10.22203\/eCM.v013a06","volume":"13","author":"B Fermor","year":"2007","unstructured":"Fermor B, Christensen SE, Youn I, Cernanec JM, Davies CM, Weinberg JB (2007) Oxygen, nitric oxide and articular cartilage. Eur Cell Mater 13:56\u201365","journal-title":"Eur Cell Mater"},{"key":"9939_CR10","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1007\/s12015-012-9374-7","volume":"8","author":"C Ferretti","year":"2012","unstructured":"Ferretti C, Borsari V, Falconi M, Gigante A, Lazzarini R, Fini M, Di Primio R, Mattioli- Belmonte M (2012) Human periosteum-derived stem cells for tissue engineering applications: the role of VEGF. Stem Cell Rev Rep 8:882\u2013890","journal-title":"Stem Cell Rev Rep"},{"key":"9939_CR11","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jcyt.2012.12.009","volume":"15","author":"K Froelich","year":"2013","unstructured":"Froelich K, Mickler J, Steusloff G, Technau A, Ramos Tirado M, Scherzed A, Hackenberg S, Radeloff A, Hagen R, Kleinsasser N (2013) Chromosomal aberrations and deoxyribonucleic acid single-strand breaks in adipose-derived stem cells during long-term expansion in vitro. Cytotherapy 15:767\u2013781","journal-title":"Cytotherapy"},{"key":"9939_CR12","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/01.RES.0000265074.83288.09","volume":"100","author":"JM Gimble","year":"2007","unstructured":"Gimble JM, Katz AJ, Bunnell BA (2007) Adipose-derived stem cells for regenerative medicine. Circ Res 100:1249\u20131260","journal-title":"Circ Res"},{"key":"9939_CR13","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.bbrc.2007.05.054","volume":"358","author":"WL Grayson","year":"2007","unstructured":"Grayson WL, Zhao F, Bunnell B, Ma T (2007) Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells. Biochem Biophys Res Commun 358:948\u2013953","journal-title":"Biochem Biophys Res Commun"},{"key":"9939_CR14","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1089\/scd.2012.0602","volume":"22","author":"ST Hsiao","year":"2013","unstructured":"Hsiao ST, Lokmic Z, Peshavariya H, Abberton KM, Dusting GJ, Lim SY, Dilley RJ (2013) Hypoxic conditioning enhances the angiogenic paracrine activity of human adipose derived stem cells. Stem Cells Dev 22:1614\u20131623","journal-title":"Stem Cells Dev"},{"key":"9939_CR15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s12015-009-9069-x","volume":"5","author":"YC Huang","year":"2009","unstructured":"Huang YC, Yang ZM, Chen XH, Tan MY, Wang J, Li XQ, Xie HQ, Deng L (2009) Isolation of mesenchymal stem cells from human placental decidua basalis and resistance to hypoxia and serum deprivation. Stem Cell Rev 5:247\u2013255","journal-title":"Stem Cell Rev"},{"key":"9939_CR16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/jcp.21690","volume":"219","author":"Z Ivanovic","year":"2009","unstructured":"Ivanovic Z (2009) Hypoxia or in situ normoxia: the stem cell paradigm. J Cell Physiol 219:271\u2013275","journal-title":"J Cell Physiol"},{"key":"9939_CR17","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1016\/j.biomaterials.2010.01.050","volume":"31","author":"T Jiang","year":"2010","unstructured":"Jiang T, Liu W, Lv X, Sun H, Zhang L, Liu Y, Zhang WJ, Cao Y, Zhou G (2010) Potent in vitro chondrogenesis of CD105 enriched human adipose-derived stem cells. Biomaterials 31:3564\u20133571","journal-title":"Biomaterials"},{"key":"9939_CR18","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrendo.2010.155","volume":"6","author":"M Kawai","year":"2010","unstructured":"Kawai M, Rosen CJ (2010) PPARgamma: a circadian transcription factor in adipogenesis and osteogenesis. Nat Rev Endocrinol 6:629\u2013636","journal-title":"Nat Rev Endocrinol"},{"key":"9939_CR19","first-page":"25","volume":"7","author":"MM Lalu","year":"2012","unstructured":"Lalu MM, McIntyre L, Pugliese C, Fergusson D, Winston BW, Marshall JC, Granton J, Stewart DJ (2012) Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. PLoS One 7:25","journal-title":"PLoS One"},{"key":"9939_CR20","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1524-475X.2009.00499.x","volume":"17","author":"EY Lee","year":"2009","unstructured":"Lee EY, Xia Y, Kim WS, Kim MH, Kim TH, Kim KJ, Park BS, Sung JH (2009) Hypoxia-enhanced wound-healing function of adipose-derived stem cells: increase in stem cell proliferation and up-regulation of VEGF and bFGF. Wound Repair Regen 17:540\u2013547","journal-title":"Wound Repair Regen"},{"key":"9939_CR21","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3109\/14653240903233081","volume":"11","author":"B Lindroos","year":"2009","unstructured":"Lindroos B, Boucher S, Chase L, Kuokkanen H, Huhtala H, Haataja R, Vemuri M, Suuronen R, Miettinen S (2009) Serum-free, xeno-free culture media maintain the proliferation rate and multipotentiality of adipose stem cells in vitro. Cytotherapy 11:958\u2013972","journal-title":"Cytotherapy"},{"key":"9939_CR22","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1002\/cyto.a.22220","volume":"81","author":"AR Lobba","year":"2012","unstructured":"Lobba AR, Forni MF, Carreira AC, Sogayar MC (2012) Differential expression of CD90 and CD14 stem cell markers in malignant breast cancer cell line.s. Cytometry A 81:1084\u20131091","journal-title":"Cytometry A"},{"key":"9939_CR23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s002620050614","volume":"49","author":"A Mackensen","year":"2000","unstructured":"Mackensen A, Drager R, Schlesier M, Mertelsmann R, Lindemann A (2000) Presence of IgE antibodies to bovine serum albumin in a patient developing anaphylaxis after vaccination with human peptide-pulsed dendritic cells. Cancer Immunol Immunother 49:152\u2013156","journal-title":"Cancer Immunol Immunother"},{"key":"9939_CR24","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1002\/mrm.20714","volume":"54","author":"A Matsumoto","year":"2005","unstructured":"Matsumoto A, Matsumoto S, Sowers AL, Koscielniak JW, Trigg NJ, Kuppusamy P, Mitchell JB, Subramanian S, Krishna MC, Matsumoto K-i (2005) Absolute oxygen tension (pO2) in murine fatty and muscle tissue as determined by EPR. Magn Reson Med 54:1530\u20131535. doi: 10.1002\/mrm.20714","journal-title":"Magn Reson Med"},{"key":"9939_CR25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1152\/ajpcell.00398.2009","volume":"298","author":"C Merceron","year":"2010","unstructured":"Merceron C, Vinatier C, Portron S, Masson M, Amiaud J, Guigand L, Cherel Y, Weiss P, Guicheux J (2010) Differential effects of hypoxia on osteochondrogenic potential of human adipose-derived stem cells. Am J Physiol Cell Physiol 298:25","journal-title":"Am J Physiol Cell Physiol"},{"key":"9939_CR26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/exmp.2002.2424","volume":"72","author":"AM Muller","year":"2002","unstructured":"Muller AM, Hermanns MI, Skrzynski C, Nesslinger M, Muller KM, Kirkpatrick CJ (2002) Expression of the endothelial markers PECAM-1, vWf, and CD34 in vivo and in vitro. Exp Mol Pathol 72:221\u2013229","journal-title":"Exp Mol Pathol"},{"key":"9939_CR27","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1242\/jcs.037507","volume":"121","author":"JS Nielsen","year":"2008","unstructured":"Nielsen JS, McNagny KM (2008) Novel functions of the CD34 family. J Cell Sci 121:3683\u20133692","journal-title":"J Cell Sci"},{"key":"9939_CR28","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1080\/14653240701508452","volume":"9","author":"A Parker","year":"2007","unstructured":"Parker A, Shang H, Khurgel M, Katz A (2007) Low serum and serum-free culture of multipotential human adipose stem cells. Cytotherapy 9:637\u2013646","journal-title":"Cytotherapy"},{"key":"9939_CR29","doi-asserted-by":"publisher","first-page":"718","DOI":"10.2337\/db08-1098","volume":"58","author":"M Pasarica","year":"2008","unstructured":"Pasarica M, Sereda OR, Redman LM, Albarado DC, Hymel DT, Roan LE, Rood JC, Burk DH, Smith SR (2008) Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes 58:718\u2013725. doi: 10.2337\/db08-1098","journal-title":"Diabetes"},{"key":"9939_CR30","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1126\/science.284.5411.143","volume":"284","author":"MF Pittenger","year":"1999","unstructured":"Pittenger MF (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143\u2013147. doi: 10.1126\/science.284.5411.143","journal-title":"Science"},{"key":"9939_CR31","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1089\/ten.2006.0325","volume":"13","author":"E Potier","year":"2007","unstructured":"Potier E, Ferreira E, Meunier A, Sedel L, Logeart-Avramoglou D, Petite H (2007) Prolonged hypoxia concomitant with serum deprivation induces massive human mesenchymal stem cell death. Tissue Eng 13:1325\u20131331","journal-title":"Tissue Eng"},{"key":"9939_CR32","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1111\/j.1537-2995.2007.01220.x","volume":"47","author":"K Schallmoser","year":"2007","unstructured":"Schallmoser K, Bartmann C, Rohde E, Reinisch A, Kashofer K, Stadelmeyer E, Drexler C, Lanzer G, Linkesch W, Strunk D (2007) Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells. Transfusion 47:1436\u20131446","journal-title":"Transfusion"},{"key":"9939_CR33","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1634\/stemcells.2005-0094","volume":"23","author":"A Shahdadfar","year":"2005","unstructured":"Shahdadfar A, Fronsdal K, Haug T, Reinholt FP, Brinchmann JE (2005) In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability. Stem Cells 23:1357\u20131366","journal-title":"Stem Cells"},{"key":"9939_CR34","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1182\/blood.V73.1.284.284","volume":"73","author":"DL Simmons","year":"1989","unstructured":"Simmons DL, Tan S, Tenen DG, Nicholson-Weller A, Seed B (1989) Monocyte antigen CD14 is a phospholipid anchored membrane protein. Blood 73:284\u2013289","journal-title":"Blood"},{"key":"9939_CR35","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ymthe.2004.02.012","volume":"9","author":"JL Spees","year":"2004","unstructured":"Spees JL, Gregory CA, Singh H, Tucker HA, Peister A, Lynch PJ, Hsu SC, Smith J, Prockop DJ (2004) Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy. Mol Ther 9:747\u2013756","journal-title":"Mol Ther"},{"key":"9939_CR36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2184.2012.00817.x","volume":"45","author":"MG Valorani","year":"2012","unstructured":"Valorani MG, Montelatici E, Germani A, Biddle A, D\u2019Alessandro D, Strollo R, Patrizi MP, Lazzari L, Nye E, Otto WR, Pozzilli P, Alison MR (2012) Pre-culturing human adipose tissue mesenchymal stem cells under hypoxia increases their adipogenic and osteogenic differentiation potentials. Cell Prolif 45:225\u2013238","journal-title":"Cell Prolif"},{"key":"9939_CR37","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/jcp.20324","volume":"204","author":"DW Wang","year":"2005","unstructured":"Wang DW, Fermor B, Gimble JM, Awad HA, Guilak F (2005) Influence of oxygen on the proliferation and metabolism of adipose derived adult stem cells. J Cell Physiol 204:184\u2013191","journal-title":"J Cell Physiol"},{"key":"9939_CR38","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1089\/ten.tea.2010.0661","volume":"17","author":"EM Weijers","year":"2011","unstructured":"Weijers EM, Van Den Broek LJ, Waaijman T, Van Hinsbergh VW, Gibbs S, Koolwijk P (2011) The influence of hypoxia and fibrinogen variants on the expansion and differentiation of adipose tissue-derived mesenchymal stem cells. Tissue Eng Part A 17:2675\u20132685","journal-title":"Tissue Eng Part A"},{"key":"9939_CR39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.yexmp.2012.08.003","volume":"94","author":"N Xu","year":"2013","unstructured":"Xu N, Liu H, Qu F, Fan J, Mao K, Yin Y, Liu J, Geng Z, Wang Y (2013) Hypoxia inhibits the differentiation of mesenchymal stem cells into osteoblasts by activation of Notch signaling. Exp Mol Pathol 94:33\u201339","journal-title":"Exp Mol Pathol"},{"key":"9939_CR40","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1089\/ten.2007.0050","volume":"13","author":"Y Xu","year":"2007","unstructured":"Xu Y, Malladi P, Chiou M, Bekerman E, Giaccia AJ, Longaker MT (2007) In vitro expansion of adipose-derived adult stromal cells in hypoxia enhances early chondrogenesis. Tissue Eng 13:2981\u20132993","journal-title":"Tissue Eng"},{"key":"9939_CR41","doi-asserted-by":"crossref","first-page":"9596","DOI":"10.1038\/srep09596","volume":"5","author":"KW Yong","year":"2015","unstructured":"Yong KW, Pingguan-Murphy B, Xu F, Abas WA, Choi JR, Omar SZ, Azmi MA, Chua KH, Wan Safwani WK (2015a) Phenotypic and functional characterization of long-term cryopreserved human adipose-derived stem cells. Sci Rep 5:9596","journal-title":"Sci Rep"},{"key":"9939_CR42","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1089\/bio.2014.0104","volume":"13","author":"KW Yong","year":"2015","unstructured":"Yong KW, Wan Safwani WK, Xu F, Wan Abas WA, Choi JR, Pingguan-Murphy B (2015b) Cryopreservation of human mesenchymal stem cells for clinical applications. Curr Methods Chall Biopreserv Biobank 13:231\u2013239","journal-title":"Curr Methods Chall Biopreserv Biobank"},{"key":"9939_CR43","doi-asserted-by":"crossref","unstructured":"Yong KW, Wan Safwani WK, Xu F, Zhang X, Choi JR, Wan Abas WA, Omar SZ, Azmi MA, Chua KH, Pingguan-Murphy B (2015c) Assessment of tumourigenic potential in long-term cryopreserved human adipose-derived stem cells. J Tissue Eng Regen Med (in press)","DOI":"10.1038\/srep09596"},{"key":"9939_CR44","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1126\/science.287.5457.1424","volume":"287","author":"FE Young","year":"2000","unstructured":"Young FE (2000) A time for restraint. Science 287:1424","journal-title":"Science"},{"key":"9939_CR45","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1634\/stemcells.2005-0121","volume":"24","author":"W Zhu","year":"2006","unstructured":"Zhu W, Chen J, Cong X, Hu S, Chen X (2006) Hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells. Stem Cells 24:416\u2013425","journal-title":"Stem Cells"}],"container-title":["Cytotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10616-015-9939-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10616-015-9939-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10616-015-9939-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10616-015-9939-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T13:35:07Z","timestamp":1600004107000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10616-015-9939-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,4]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["9939"],"URL":"https:\/\/doi.org\/10.1007\/s10616-015-9939-9","relation":{},"ISSN":["0920-9069","1573-0778"],"issn-type":[{"value":"0920-9069","type":"print"},{"value":"1573-0778","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,4]]}}}