{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:54:05Z","timestamp":1768283645600,"version":"3.49.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"KAKENHI","award":["JP 26463082"],"award-info":[{"award-number":["JP 26463082"]}]},{"name":"KAKENHI","award":["JP 26861759"],"award-info":[{"award-number":["JP 26861759"]}]},{"name":"Osaka Dental University Research Funds","award":["16-11"],"award-info":[{"award-number":["16-11"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cytotechnology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s10616-018-0193-9","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T14:29:23Z","timestamp":1516372163000},"page":"949-959","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Functional recovery by application of human dedifferentiated fat cells on cerebral infarction mice model"],"prefix":"10.1007","volume":"70","author":[{"given":"Tomoki","family":"Kakudo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotaka","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Momota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,1,19]]},"reference":[{"key":"193_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40758","author":"B Argibay","year":"2017","unstructured":"Argibay B, Trekker J, Himmelreich U, Beiras A, Topete A, Taboada P, P\u00e9rez-Mato M, Vieites-Prado A, Iglesias-Rey R, Rivas J et al (2017) Intraarterial route increases the risk of cerebral lesions after mesenchymal cell administration in animal model of ischemia. Sci Rep. \n                    https:\/\/doi.org\/10.1038\/srep40758","journal-title":"Sci Rep"},{"key":"193_CR2","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1002\/ana.20501","volume":"57","author":"OY Bang","year":"2005","unstructured":"Bang OY, Lee JS, Lee PH, Lee G (2005) Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 57:874\u2013882. \n                    https:\/\/doi.org\/10.1002\/ana.20501","journal-title":"Ann Neurol"},{"key":"193_CR3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0022-510X(01)00557-3","volume":"189","author":"X Chen","year":"2001","unstructured":"Chen X, Li Y, Wang L, Lu M, Zhang X, Chopp M (2001) Therapeutic benefit of intracerebral ischemia in rat. J Neurol Sci 189:49\u201357. \n                    https:\/\/doi.org\/10.1016\/S0022-510X(01)00557-3","journal-title":"J Neurol Sci"},{"key":"193_CR4","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Dj Prockop, Horwitz E (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315\u2013317. \n                    https:\/\/doi.org\/10.1080\/14653240600855905","journal-title":"Cytotherapy"},{"key":"193_CR5","first-page":"37","volume":"16","author":"M Guti\u00e9rrez-Fern\u00e1ndez","year":"2013","unstructured":"Guti\u00e9rrez-Fern\u00e1ndez M, Rodr\u00edguez-Frutos B, Otero-Ortega L, Ramos-Cejudo J, Fuentes B, D\u00edez-Tejedor E (2013a) Adipose tissue-derived stem cells in stroke treatment: from bench to bedside. Discov Med 16:37\u201343","journal-title":"Discov Med"},{"key":"193_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/scrt159","volume":"4","author":"M Guti\u00e9rrez-Fern\u00e1ndez","year":"2013","unstructured":"Guti\u00e9rrez-Fern\u00e1ndez M, Rodr\u00edguez-Frutos B, Ramos-Cejudo J, Teresa Vallejo-Cremades M, Fuentes B, Cerd\u00e1n S, D\u00edez-Tejedor E (2013b) Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke. Stem Cell Res Ther 4:11. \n                    https:\/\/doi.org\/10.1186\/scrt159","journal-title":"Stem Cell Res Ther"},{"key":"193_CR7","doi-asserted-by":"publisher","first-page":"675","DOI":"10.3109\/14653249.2010.549122","volume":"13","author":"Y Ikegame","year":"2011","unstructured":"Ikegame Y, Yamashita K, Hayashi S, Mizuno H, Tawada M, You F, Yamada K, Tanaka Y, Egashira Y, Nakashima S et al (2011) Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy. Cytotherapy 13:675\u2013685. \n                    https:\/\/doi.org\/10.3109\/14653249.2010.549122","journal-title":"Cytotherapy"},{"key":"193_CR8","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1007\/s00784-013-1166-1","volume":"18","author":"N Kishimoto","year":"2014","unstructured":"Kishimoto N, Momota Y, Hashimoto Y, Tatsumi S, Ando K, Omasa T, Kotani J (2014) The osteoblastic differentiation ability of human dedifferentiated fat cells is higher than that of adipose stem cells from the buccal fat pad. Clin Oral Investig 18:1893\u20131901. \n                    https:\/\/doi.org\/10.1007\/s00784-013-1166-1","journal-title":"Clin Oral Investig"},{"key":"193_CR9","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ymthe.2003.10.012","volume":"9","author":"K Kurozumi","year":"2004","unstructured":"Kurozumi K, Nakamura K, Tamiya T, Kawano Y, Kobune M, Hirai S, Uchida H, Sasaki K, Ito Y, Kato K et al (2004) BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model. Mol Ther 9:189\u2013197. \n                    https:\/\/doi.org\/10.1016\/j.ymthe.2003.10.012","journal-title":"Mol Ther"},{"key":"193_CR10","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ymthe.2004.09.020","volume":"11","author":"K Kurozumi","year":"2005","unstructured":"Kurozumi K, Nakamura K, Tamiya T, Kawano Y, Ishii K, Kobune M, Hirai S, Uchida H, Sasaki K, Ito Y et al (2005) Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model. Mol Ther 11:96\u2013104. \n                    https:\/\/doi.org\/10.1016\/j.ymthe.2004.09.020","journal-title":"Mol Ther"},{"key":"193_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1002\/jcp.21304","volume":"215","author":"T Matsumoto","year":"2008","unstructured":"Matsumoto T, Kano K, Kondo D, Fukuda N, Iribe Y, Tanaka N, Matsubara Y, Sakuma T, Satomi A, Otaki M et al (2008) Mature adipocyte-derived dedifferentiated fat cells exhibit multilineage potential. J Cell Physiol 215:210\u2013222. \n                    https:\/\/doi.org\/10.1002\/jcp.21304","journal-title":"J Cell Physiol"},{"key":"193_CR25","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1002\/stem.161","volume":"27","author":"N Nakagomi","year":"2009","unstructured":"Nakagomi N, Nakagomi T, Kubo S, Nakano-Doi A, Saino O, Takata M, Yoshikawa H, Stern D, Matsuyama T, Taguchi A (2009a) Endothelial cells support survival, proliferation, and neuronal differentiation of transplanted adult ischemia-induced neural stem\/progenitor cells after cerebral infarction. Stem Cells 27:2185\u20132195","journal-title":"Stem Cells"},{"key":"193_CR12","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1111\/j.1460-9568.2009.06732.x","volume":"29","author":"T Nakagomi","year":"2009","unstructured":"Nakagomi T, Taguchi A, Fujimori Y, Saino O, Nakano-Doi A, Kubo S, Gotoh A, Soma T, Yoshikawa H, Nishizaki T et al (2009b) Isolation and characterization of neural stem\/progenitor cells from post-stroke cerebral cortex in mice. Eur J Neurosci 29:1842\u20131852. \n                    https:\/\/doi.org\/10.1111\/j.1460-9568.2009.06732.x","journal-title":"Eur J Neurosci"},{"key":"193_CR13","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s12975-016-0479-1","volume":"8","author":"M Nakata","year":"2017","unstructured":"Nakata M, Nakagomi T, Maeda M, Nakano-Doi A, Momota Y, Matsuyama T (2017) Induction of perivascular neural stem cells and possible contribution to neurogenesis following transient brain ischemia\/reperfusion injury. Transl Stroke Res 8:131\u2013143. \n                    https:\/\/doi.org\/10.1007\/s12975-016-0479-1","journal-title":"Transl Stroke Res"},{"key":"193_CR14","doi-asserted-by":"publisher","first-page":"877","DOI":"10.3727\/096368908786576516","volume":"17","author":"Y Ohta","year":"2008","unstructured":"Ohta Y, Takenaga M, Tokura Y, Hamaguchi A, Matsumoto T, Kano K, Mugishima H, Okano H, Igarashi R (2008) Mature adipocyte-derived cells, dedifferentiated fat cells (DFAT), promoted functional recovery from spinal cord injury-induced motor dysfunction in rat. Cell Transplant 17:877\u2013886. \n                    https:\/\/doi.org\/10.3727\/096368908786576516","journal-title":"Cell Transplant"},{"key":"193_CR15","doi-asserted-by":"publisher","first-page":"4279","DOI":"10.1091\/mbc.e02-02-0105","volume":"13","author":"AZ Patricia","year":"2002","unstructured":"Patricia AZ, Min Z, Peter A, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH (2002) Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13:4279\u20134295. \n                    https:\/\/doi.org\/10.1091\/mbc.e02-02-0105","journal-title":"Mol Biol Cell"},{"key":"193_CR16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s12031-014-0345-0","volume":"55","author":"A Poloni","year":"2015","unstructured":"Poloni A, Maurizi G, Foia F, Mondini E, Mattiucci D, Ambrogini P, Lattanzi D, Mancini S, Falconi M, Cinti S et al (2015) Glial-like differentiation potential of human mature adipocytes. J Mol Neurosci 55:91\u201398. \n                    https:\/\/doi.org\/10.1007\/s12031-014-0345-0","journal-title":"J Mol Neurosci"},{"key":"193_CR17","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1126\/science.1553558","volume":"255","author":"BA Reynolds","year":"1992","unstructured":"Reynolds BA, Weiss S (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255:1707\u20131710. \n                    https:\/\/doi.org\/10.1126\/science.1553558","journal-title":"Science"},{"key":"193_CR18","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1055\/s-2002-33033","volume":"23","author":"CL Rochester","year":"2002","unstructured":"Rochester CL, Mohsenin V (2002) Respiratory complications of stroke. Semin Respir Crit Care Med 23:248\u2013260. \n                    https:\/\/doi.org\/10.1055\/s-2002-33033","journal-title":"Semin Respir Crit Care Med"},{"key":"193_CR19","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s10616-013-9659-y","volume":"67","author":"F Sakamoto","year":"2015","unstructured":"Sakamoto F, Hashimoto Y, Kishimoto N, Honda Y, Matsumoto N (2015) The utility of human dedifferentiated fat cells in bone tissue engineering in vitro. Cytotechnology 67:75\u201384. \n                    https:\/\/doi.org\/10.1007\/s10616-013-9659-y","journal-title":"Cytotechnology"},{"key":"193_CR20","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1172\/JCI200420622","volume":"114","author":"A Taguchi","year":"2004","unstructured":"Taguchi A, Soma T, Tanaka H, Kanda T, Nishimura H, Yoshikawa H, Tsukamoto Y, Iso H, Fujimori Y, Stern DM et al (2004) Administration of CD34\u00fe cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J Clin Invest 114:330\u2013338. \n                    https:\/\/doi.org\/10.1172\/JCI20622","journal-title":"J Clin Invest"},{"key":"193_CR21","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/j.1460-9568.2007.05640.x","volume":"26","author":"A Taguchi","year":"2007","unstructured":"Taguchi A, Wen Z, Myojin K, Yoshihara T, Nakagomi T, Nakayama D, Tanaka H, Soma T, Stern DM, Naritomi H et al (2007) Granulocyte colony-stimulating factor has a negative effect on stroke outcome in a murine model. Eur J Neurosci 26:126\u2013133. \n                    https:\/\/doi.org\/10.1111\/j.1460-9568.2007.05640.x","journal-title":"Eur J Neurosci"},{"key":"193_CR22","doi-asserted-by":"publisher","first-page":"28","DOI":"10.6030\/1939-067X-3.1.28","volume":"3","author":"A Taguchi","year":"2010","unstructured":"Taguchi A, Kasahara Y, Nakagomi T, Stern DM, Fukunaga M, Ishikawa M, Matsuyama T (2010) A reproducible and simple model of permanent cerebral ischemia in CB-17 and SCID mice. J Exp Stroke Transl Med 3:28\u201333. \n                    https:\/\/doi.org\/10.6030\/1939-067X-3.1.28","journal-title":"J Exp Stroke Transl Med"},{"key":"193_CR23","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1038\/mp.2009.110","volume":"15","author":"M Tfilin","year":"2010","unstructured":"Tfilin M, Sudai E, Merenlender A, Gispan I, Yadid G, Turgeman G (2010) Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior. Mol Psychiatry 15:1164\u20131175. \n                    https:\/\/doi.org\/10.1038\/mp.2009.110","journal-title":"Mol Psychiatry"},{"key":"193_CR24","first-page":"25","volume":"21","author":"KI Umarova","year":"2007","unstructured":"Umarova KI, Chugunov AV, Agapov AA, Kamchatnov PR (2007) Pneumonia in patients with acute brain stroke. Zh Nevrol Psikhiatr Im S S Korsakova Suppl 21:25\u201329","journal-title":"Zh Nevrol Psikhiatr Im S S Korsakova Suppl"}],"container-title":["Cytotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10616-018-0193-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10616-018-0193-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10616-018-0193-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T00:17:26Z","timestamp":1547857046000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10616-018-0193-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,19]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["193"],"URL":"https:\/\/doi.org\/10.1007\/s10616-018-0193-9","relation":{},"ISSN":["0920-9069","1573-0778"],"issn-type":[{"value":"0920-9069","type":"print"},{"value":"1573-0778","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,19]]},"assertion":[{"value":"23 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}