{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:53:18Z","timestamp":1793641998571,"version":"4.5.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Ege University BAP project","award":["2013\/ FEN\/ 015"],"award-info":[{"award-number":["2013\/ FEN\/ 015"]}]},{"name":"T\u00dcB\u0130TAK","award":["2211 Scholarship"],"award-info":[{"award-number":["2211 Scholarship"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cytotechnology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s10616-019-00314-5","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T16:28:38Z","timestamp":1554913718000},"page":"687-704","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Apoptosis-inducing activities of Halopteris scoparia L. Sauvageau (Brown algae) on cancer cells and its biosafety and antioxidant properties"],"prefix":"10.1007","volume":"71","author":[{"given":"Adem","family":"G\u00fcner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"Nalbantsoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atakan","family":"Sukatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nefise \u00dclk\u00fc","family":"Karabay Yava\u015fo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,9]]},"reference":[{"key":"314_CR1","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1042\/BST20140070","volume":"42","author":"AG Abraham","year":"2014","unstructured":"Abraham AG, O\u2019Neill E (2014) PI3\u00a0K\/Akt-mediated regulation of p53 in cancer. Biochem Soc Trans 42:798\u2013803","journal-title":"Biochem Soc Trans"},{"key":"314_CR2","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.coi.2007.05.004","volume":"19","author":"JM Adams","year":"2007","unstructured":"Adams JM, Cory S (2007) Bcl-2-regulated apoptosis: mechanism and therapeutic potential. Curr Opin Immunol 19:488\u2013496","journal-title":"Curr Opin Immunol"},{"key":"314_CR3","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1126\/science.281.5381.1305","volume":"281","author":"A Ashkenazi","year":"1998","unstructured":"Ashkenazi A, Dixit VM (1998) Death receptors: signaling and modulation. Science 281:1305\u20131308","journal-title":"Science"},{"key":"314_CR4","volume-title":"Principles of toxicology testing","author":"FA Barile","year":"2008","unstructured":"Barile FA (2008) Principles of toxicology testing. CRC Press, New York"},{"key":"314_CR5","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1039\/b906091j","volume":"27","author":"JW Blunt","year":"2010","unstructured":"Blunt JW, Copp BR, Munro MH, Northcote PT, Prinsep MR (2010) Marine natural product. Nat Prod Rep 27:165\u2013237","journal-title":"Nat Prod Rep"},{"key":"314_CR6","volume-title":"Guide mes algues des mers d\u2019Europe","author":"J Cabioc\u2019h","year":"1992","unstructured":"Cabioc\u2019h J, Floc\u2019h J, Le Toquin A (1992) Guide mes algues des mers d\u2019Europe. Delachaux et Niestle, Paris"},{"key":"314_CR7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.foodchem.2010.02.012","volume":"122","author":"K Chakraborty","year":"2010","unstructured":"Chakraborty K, Paulraj R (2010) Sesquiterpenoids with free radical scavenging properties from marine macroalga Ulva fasciata Delile. Food Chem 122:31\u201341","journal-title":"Food Chem"},{"key":"314_CR8","first-page":"178","volume":"10","author":"CC Chang","year":"2002","unstructured":"Chang CC, Yang MH, Wen HM, Chern JC (2002) Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal 10:178\u2013182","journal-title":"J Food Drug Anal"},{"key":"314_CR9","doi-asserted-by":"publisher","first-page":"7429","DOI":"10.1021\/jf0611668","volume":"54","author":"Z Cheng","year":"2006","unstructured":"Cheng Z, Moore J, Yu L (2006) High-throughput relative DPPH radical scavenging capacity assay. J Agric Food Chem 54:7429\u20137436","journal-title":"J Agric Food Chem"},{"key":"314_CR10","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1158\/1541-7786.MCR-09-0239","volume":"7","author":"KC Choi","year":"2009","unstructured":"Choi KC, Lee YH, Jung MG, Kwon SH, Kim MJ, Jun WJ, Lee J, Lee JM, Yoon HG (2009) Gallic acid suppresses lipopolysaccharide-induced nuclear factor-kappaB signaling by preventing rel A acetylation in A549 lung cancer cells. Mol Cancer Res 7:2011\u20132021","journal-title":"Mol Cancer Res"},{"key":"314_CR11","doi-asserted-by":"publisher","first-page":"155","DOI":"10.4490\/algae.2010.25.4.155","volume":"25","author":"ML Cornish","year":"2010","unstructured":"Cornish ML, Garbary DJ (2010) Antioxidants from macroalgae: potential applications in human health and nutrition. Algae 25:155\u2013171","journal-title":"Algae"},{"key":"314_CR12","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s00394-008-2006-y","volume":"47","author":"TM Kok De","year":"2008","unstructured":"De Kok TM, Van Breda SG, Manson MM (2008) Mechanisms of combined action of different chemopreventive dietary compounds: a review. Eur J Nutr 47:51\u201359","journal-title":"Eur J Nutr"},{"key":"314_CR13","first-page":"5927","volume":"16","author":"Z Demirel","year":"2011","unstructured":"Demirel Z, Y\u0131lmaz-Koz FF, Karabay-Yavasoglu NU, Ozdem\u0131r G, Sukatar A (2011) Antimicrobial and antioxidant activities of solvent extracts and the essential oil composition of Laurencia obtusa and Laurencia obtusa var. pyramidata. Rom Biotechnol Lett 16:5927\u20135936","journal-title":"Rom Biotechnol Lett"},{"key":"314_CR14","volume-title":"CRC handbook of toxicology","year":"1995","unstructured":"Derelanko MJ, Hollinger MA (eds) (1995) CRC handbook of toxicology, 2nd edn. CRC Press, Boca Raton","edition":"2"},{"key":"314_CR15","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s12010-011-9178-2","volume":"164","author":"S Ermakova","year":"2011","unstructured":"Ermakova S, Sokolova R, Kim SM, Um BH, Isakov V, Zvyagintseva T (2011) Fucoidans from brown seaweeds Sargassum hornery, Eclonia cava, Costaria costata: structural characteristics and anticancer activity. Appl Biochem Biotechnol 164:841\u2013850","journal-title":"Appl Biochem Biotechnol"},{"key":"314_CR16","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","volume":"281","author":"DR Green","year":"1998","unstructured":"Green DR, Reed JC (1998) Mitochondria and apoptosis. Science 281:1309\u20131312","journal-title":"Science"},{"key":"314_CR17","doi-asserted-by":"publisher","first-page":"279","DOI":"10.21448\/ijsm.432654","volume":"5","author":"A G\u00fcner","year":"2018","unstructured":"G\u00fcner A, Karabay Yavaso\u011flu NU (2018) Evaluation of antioxidant, antimicrobial and antimutagenic activity with irritation effects of Ceramium rubrum (Red Algae) extract. Int J Second Metab 5:279\u2013287","journal-title":"Int J Second Metab"},{"key":"314_CR18","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s10616-013-9668-x","volume":"67","author":"A G\u00fcner","year":"2015","unstructured":"G\u00fcner A, K\u00f6ksal \u00c7, Erel \u015eB, Kayalar H, Nalbantsoy A, Sukatar A, Karabay Yava\u015fo\u011flu N\u00dc (2015) Antimicrobial and antioxidant activities with acute toxicity, cytotoxicity and mutagenicity of Cystoseira compressa (Esper) Gerloff & Nizamuddin from the coast of Urla (Izmir, Turkey). Cytotechnology 67:135\u2013143","journal-title":"Cytotechnology"},{"key":"314_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mam.2005.07.008","volume":"27","author":"A Gurib-Fakim","year":"2006","unstructured":"Gurib-Fakim A (2006) Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspects Med 27:1\u201393","journal-title":"Mol Aspects Med"},{"key":"314_CR20","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s10811-010-9632-5","volume":"23","author":"SL Holdt","year":"2011","unstructured":"Holdt SL, Kraan S (2011) Bioactive compounds in seaweed: functional food applications and legislation. J Appl Phycol 23:543\u2013597","journal-title":"J Appl Phycol"},{"key":"314_CR21","doi-asserted-by":"publisher","first-page":"7596","DOI":"10.1021\/jf901308p","volume":"57","author":"BC Ji","year":"2009","unstructured":"Ji BC, Hsu WH, Yang JS, Hsia TC, Lu CC, Chiang JH, Yang JL, Lin CH, Lin JJ, Suen LJ, Gibson Wood W, Chung JG (2009) Gallic acid induces apoptosis via caspase-3 and mitochondrion-dependent pathways in vitro and suppresses lung xenograft tumor growth in vivo. J Agric Food Chem 57:7596\u20137604","journal-title":"J Agric Food Chem"},{"key":"314_CR22","first-page":"4","volume":"2","author":"Z Jubri","year":"2012","unstructured":"Jubri Z, Najib Narayanan NN, Norwahidah AK, Wan Ngah WZ (2012) Antiproliferative activity and apoptosis induction by Gelam honey on liver cancer cell line. Int J Appl Sci Technol 2:4","journal-title":"Int J Appl Sci Technol"},{"key":"314_CR23","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/S0962-8924(01)02173-0","volume":"11","author":"SH Kaufmann","year":"2001","unstructured":"Kaufmann SH, Hengartner MO (2001) Programmed cell death: alive and well in the new millennium. Trends Cell Biol 11:526\u2013534","journal-title":"Trends Cell Biol"},{"key":"314_CR24","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/S0367-326X(99)00005-2","volume":"70","author":"MR Khan","year":"1999","unstructured":"Khan MR, Mlungwana SM (1999) C-sitosterol, a cytotoxic sterol from Markhamia zanzibarica and Kigelia Africana. Fitoterapia 70:96\u201397","journal-title":"Fitoterapia"},{"key":"314_CR25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4067\/S0716-97602010000100005","volume":"43","author":"M Khanavi","year":"2010","unstructured":"Khanavi M, Nabavi M, Sadati N, Ardekani MS, Sohrabipour J, Nabavi BM, Ghaeli P, Ostad NS (2010) Cytotoxic activity of some marine brown algae against cancer cell lines. Biol Res 43:31\u201337","journal-title":"Biol Res"},{"key":"314_CR26","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/B978-0-12-387669-0.00016-8","volume":"64","author":"SK Kim","year":"2011","unstructured":"Kim SK, Thomas NV, Li X (2011) Anticancer compounds from marine macroalgae and their application as medical foods. Adv Food Nutr Res 64:213\u2013224","journal-title":"Adv Food Nutr Res"},{"key":"314_CR27","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1080\/10915810802656996","volume":"27","author":"AS Kishore","year":"2008","unstructured":"Kishore AS, Surekha PA, Sekhar PV, Srinivas A, Murthy PB (2008) Hen egg chorioallantoic membrane bioassay: an in vitro alternative to Draize eye irritation test for pesticide screening. Int J Toxicol 27:449\u2013453","journal-title":"Int J Toxicol"},{"key":"314_CR28","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"314_CR29","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/S0092-8674(01)00237-9","volume":"104","author":"RM Locksley","year":"2001","unstructured":"Locksley RM, Killeen N, Lenardo MJ (2001) The TNF and TNF receptor super families: integrating mammalian biology. Cell 104:487\u2013501","journal-title":"Cell"},{"key":"314_CR30","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/ncponc0140","volume":"2","author":"JR Mann","year":"2005","unstructured":"Mann JR, Backlund MG, DuBois RN (2005) Mechanisms of disease: inflammatory mediators and cancer prevention. Nat Clin Pract Oncol 2:202\u2013210","journal-title":"Nat Clin Pract Oncol"},{"key":"314_CR31","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3390\/md16050165","volume":"16","author":"K Mart\u00ednez Andrade","year":"2018","unstructured":"Mart\u00ednez Andrade K, Lauritano C, Romano G, Ianora A (2018) Marine microalgae with anti-cancer properties. Marine Drugs 16:165","journal-title":"Marine Drugs"},{"key":"314_CR32","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.foodchem.2004.10.006","volume":"91","author":"A Meda","year":"2005","unstructured":"Meda A, Lamien CE, Romito M, Millogo J, Nacoulma OG (2005) Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity. Food Chem 91:571\u2013577","journal-title":"Food Chem"},{"key":"314_CR33","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.canlet.2004.06.007","volume":"218","author":"SU Mertens-Talcott","year":"2005","unstructured":"Mertens-Talcott SU, Percival SS (2005) Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett 218:141\u2013151","journal-title":"Cancer Lett"},{"key":"314_CR34","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55\u201363","journal-title":"J Immunol Methods"},{"key":"314_CR35","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1021\/np200906s","volume":"75","author":"DJ Newman","year":"2012","unstructured":"Newman DJ, Cragg GM (2012) Natural products as sources of new drugs over the 30\u00a0years from 1981 to 2010. J Nat Prod 75:311\u2013335","journal-title":"J Nat Prod"},{"key":"314_CR36","first-page":"129","volume-title":"Production of bioactive secondary metabolites: biotechnology for agro-industrial residues utilization","author":"PS Nigam","year":"2009","unstructured":"Nigam PS, Pandey A (2009) Production of bioactive secondary metabolites: biotechnology for agro-industrial residues utilization, 1st edn. Springer, Netherlands, pp 129\u2013145","edition":"1"},{"key":"314_CR37","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s11010-010-0709-x","volume":"351","author":"MS Ola","year":"2011","unstructured":"Ola MS, Nawaz M, Ahsan H (2011) Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem 351:41\u201358","journal-title":"Mol Cell Biochem"},{"key":"314_CR38","doi-asserted-by":"publisher","first-page":"734","DOI":"10.3892\/ijmm.2012.1084","volume":"30","author":"HK Park","year":"2012","unstructured":"Park HK, Kim IH, Kim J, Nam TJ (2012) Induction of apoptosis by laminarin, regulating the insulin-like growth factor-IR signaling pathways in HT-29 human colon cells. Int J Mol Med 30:734\u2013738","journal-title":"Int J Mol Med"},{"key":"314_CR39","first-page":"15","volume-title":"Seaweed: ecology, nutrient composition and medicinal uses","author":"L Pereira","year":"2011","unstructured":"Pereira L (2011) A rev\u0131ew of the nutr\u0131ent compos\u0131t\u0131on of selected ed\u0131ble seaweeds. In: Pomin VH (ed) Seaweed: ecology, nutrient composition and medicinal uses. Nova Science Publishers Inc, Nova lorque, pp 15\u201347"},{"key":"314_CR40","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1201\/b19970","volume-title":"Edible seaweeds of the world","author":"L Pereira","year":"2016","unstructured":"Pereira L (2016) Edible seaweeds of the world. CRC Press, Boca Raton, p 52"},{"key":"314_CR41","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/mnfr.200700326","volume":"52","author":"S Ramos","year":"2008","unstructured":"Ramos S (2008) Cancer chemoprevention and chemo- therapy: dietary polyphenols and signalling pathways. Mol Nutr Food Res 52:507\u2013526","journal-title":"Mol Nutr Food Res"},{"key":"314_CR42","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","volume":"26","author":"R Re","year":"1999","unstructured":"Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26:1231\u20131237","journal-title":"Free Radic Biol Med"},{"key":"314_CR43","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S0092-8674(00)80430-4","volume":"91","author":"GS Salvesen","year":"1997","unstructured":"Salvesen GS, Dixit VM (1997) Caspase activation: the induced-proximity model. Cell 91:443\u2013446","journal-title":"Cell"},{"key":"314_CR44","first-page":"321","volume-title":"Remarques sur les Sphac\u00e9lariac\u00e9es","author":"C Sauvageau","year":"1904","unstructured":"Sauvageau C (1904) Remarques sur les Sphac\u00e9lariac\u00e9es, vol 2. F\u00e9ret et fils, Bordeaux, pp 321\u2013480"},{"key":"314_CR45","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.ijbiomac.2013.06.030","volume":"60","author":"K Senthilkumar","year":"2013","unstructured":"Senthilkumar K, Manivasagan P, Venkatesan J, Kim SK (2013) Brown seaweed fucoidan: biological activity and apoptosis, growth signaling mechanism in cancer. Int J Biol Macromol 60:366\u2013374","journal-title":"Int J Biol Macromol"},{"key":"314_CR46","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s12035-014-8700-2","volume":"51","author":"S Shailasree","year":"2015","unstructured":"Shailasree S, Venkataramana M, Niranjana SR, Prakash HS (2015) Cytotoxic effect of p-coumaric acid on neuroblastoma, N2a cell via generation of reactive oxygen species leading to dysfunction of mitochondria inducing apoptosis and autophagy. Mol Neurobiol 51:119\u2013130","journal-title":"Mol Neurobiol"},{"key":"314_CR47","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1158\/1535-7163.333.4.2","volume":"4","author":"TL Simmons","year":"2005","unstructured":"Simmons TL, Andrianasolo E, McPhail K, Flatt PM, Gerwick WH (2005) Marine natural products as anticancer drugs. Mol Cancer Ther 4:333\u2013342","journal-title":"Mol Cancer Ther"},{"key":"314_CR48","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.jfca.2006.01.003","volume":"19","author":"K Thaipong","year":"2006","unstructured":"Thaipong K, Boonprakob U, Crosby K, Cisneros-Zevallos L, Hawkins D (2006) Comparison of ABTS, DPHH, FRAP, and ORAC assays for estimating antioxidant activity from guava fruit extracts. J Food Compost Anal 19:669\u2013675","journal-title":"J Food Compost Anal"},{"key":"314_CR49","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1126\/science.7878464","volume":"267","author":"CB Thompson","year":"1995","unstructured":"Thompson CB (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267:1456\u20131462","journal-title":"Science"},{"key":"314_CR50","first-page":"1146","volume":"5","author":"A Turko\u011flu","year":"2006","unstructured":"Turko\u011flu A, K\u0131vrak I, Mercan N, Duru ME, Gezer K, Turko\u011flu H (2006) Antioxidant and antimicrobial activities of Morchella conica Pers. African J Biotechnol 5:1146\u20131150","journal-title":"African J Biotechnol"},{"key":"314_CR51","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1080\/10942910601052715","volume":"10","author":"LJ Wang","year":"2007","unstructured":"Wang LJ, Li D, Zou XD, Yong-Qiang Chen C (2007) Antioxidative activity of Douchi (A Chinese traditional salt fermented soybean food) extracts during processing. Int J Food Properties 10:385\u2013396","journal-title":"Int J Food Properties"},{"key":"314_CR52","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s10616-013-9540-z","volume":"66","author":"HT Yal\u00e7\u0131n","year":"2014","unstructured":"Yal\u00e7\u0131n HT, Ozen MO, Gocmen B, Nalbantsoy A (2014) Effect of ottoman viper (Montivipera xanthina (Gray, 1849)) venom on various cancer cells and on microorganisms. Cytotechnology 66:87\u201394","journal-title":"Cytotechnology"},{"key":"314_CR53","doi-asserted-by":"publisher","first-page":"5370","DOI":"10.1038\/sj.onc.1209535","volume":"25","author":"B Yan","year":"2006","unstructured":"Yan B, Wang H, Wang H, Zhuo D, Li F, Kon T, Dewhirst M, Li CY (2006) Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner. Oncogene 25:5370\u20135376","journal-title":"Oncogene"},{"key":"314_CR54","first-page":"159","volume":"13","author":"E Yusnawan","year":"2013","unstructured":"Yusnawan E (2013) The effectiveness of polar and non polar fractions of Ageratum conyzo\u0131des L. to control peanut rust d\u0131sease and phytochem\u0131cal screen\u0131ngs of secondary metabol\u0131tes. J Hpt Tropika 13:159\u2013166","journal-title":"J Hpt Tropika"},{"key":"314_CR55","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","volume":"16","author":"M Zimmermann","year":"1983","unstructured":"Zimmermann M (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109\u2013110","journal-title":"Pain"},{"key":"314_CR56","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1515\/BOT.2009.037","volume":"52","author":"M Zubia","year":"2009","unstructured":"Zubia M, Fabre MS, Kerjean V, Deslandes E (2009) Antioxidant and cytotoxic activities of some red algae (Rhodophyta) from Brittany coasts (France). Bot Mar 52:268\u2013277","journal-title":"Bot Mar"}],"container-title":["Cytotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10616-019-00314-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10616-019-00314-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10616-019-00314-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T18:13:33Z","timestamp":1663265613000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10616-019-00314-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,9]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["314"],"URL":"https:\/\/doi.org\/10.1007\/s10616-019-00314-5","relation":{},"ISSN":["0920-9069","1573-0778"],"issn-type":[{"value":"0920-9069","type":"print"},{"value":"1573-0778","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,9]]},"assertion":[{"value":"7 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}